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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethisterone
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Accession:CHEBI:34749 term browser browse the term
Definition:A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.
Synonyms:exact_synonym: (17alpha)-17-hydroxypregn-4-en-20-yn-3-one
 related_synonym: 17-beta-hydroxy-17-alpha-ethynyl-4-androsten-3-one;   17-ethynyl-17beta-hydroxyandrost-4-en-3-one;   17-hydroxy-17alpha-pregn-4-en-20-yn-3-one;   17alpha-ethinyltestosterone;   17alpha-ethynyl-17beta-hydroxyandrost-4-en-3-one;   17alpha-ethynyltestosterone;   Formula=C21H28O2;   InChI=1S/C21H28O2/c1-4-21(23)12-9-18-16-6-5-14-13-15(22)7-10-19(14,2)17(16)8-11-20(18,21)3/h1,13,16-18,23H,5-12H2,2-3H3/t16-,17+,18+,19+,20+,21+/m1/s1;   InChIKey=CHNXZKVNWQUJIB-CEGNMAFCSA-N;   Lutocylol;   Nugestoral;   Ora-Lutin;   Pranone;   Prodroxan;   Produxan;   Progestab;   Progestoral;   SMILES=C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@]2(O)C#C;   Syngestrotabs;   Trosinone;   aethisteron;   aethisteronum;   anhydrohydroxyprogesterone;   anhydroxyprogesterone;   ethisteronum;   ethynyltestosterone;   etisterona
 xref: CAS:434-03-7;   Drug_Central:1084;   HMDB:HMDB0060580;   KEGG:C14487
 xref_mesh: MESH:D005003
 xref: PMID:13494335;   PMID:374128;   PMID:8327560;   Reaxys:1889895;   Wikipedia:Ethisterone



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ethisterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein affects the reaction [Ethisterone results in increased expression of GREB1 mRNA]; ESR1 protein affects the reaction [Ethisterone results in increased expression of SGK1 mRNA] CTD PMID:33405908 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO ESR1 protein affects the reaction [Ethisterone results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [Ethisterone results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Mybl1 MYB proto-oncogene like 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Ethisterone results in increased expression of MYBL1 mRNA] CTD PMID:33405908 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression
ISO ESR1 protein affects the reaction [Ethisterone results in increased expression of SGK1 mRNA]; Fulvestrant inhibits the reaction [Ethisterone results in increased expression of SGK1 mRNA] CTD PMID:33405908 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19915
    chemical entity 19913
      group 19866
        organic group 19007
          3-oxo-Delta(4)-steroid group 9164
            3-oxo-Delta(4) steroid 9175
              ethisterone 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19915
    subatomic particle 19913
      composite particle 19895
        hadron 19895
          baryon 19913
            nucleon 19895
              atomic nucleus 19913
                atom 19895
                  main group element atom 19852
                    p-block element atom 19834
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19542
                              organochalcogen compound 19302
                                organooxygen compound 19218
                                  carbonyl compound 18920
                                    ketone 17270
                                      oxo steroid 10544
                                        3-oxo steroid 9923
                                          3-oxo-Delta(4) steroid 9175
                                            testosterone 4783
                                              ethisterone 4
paths to the root