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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dimethoate
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Accession:CHEBI:34714 term browser browse the term
Definition:A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.
Synonyms:exact_synonym: O,O-dimethyl S-[2-(methylamino)-2-oxoethyl] phosphorodithioate
 related_synonym: 2-Dimethoxyphosphinothioylthio-N-methylacetamide;   Formula=C5H12NO3PS2;   InChI=1S/C5H12NO3PS2/c1-6-5(7)4-12-10(11,8-2)9-3/h4H2,1-3H3,(H,6,7);   InChIKey=MCWXGJITAZMZEV-UHFFFAOYSA-N;   O,O-dimethyl S-[2-(methylamino)-2-oxoethyl] dithiophosphate;   Phosphamide;   Phosphorodithioic acid, O,O-dimethyl S-(2-(methylamino)-2-oxoethyl) ester;   SMILES=CNC(=O)CSP(=S)(OC)OC
 xref: CAS:60-51-5;   KEGG:C14326;   LINCS:LSM-24992
 xref_mesh: MESH:D004117
 xref: PMID:11054639;   PMID:15803959;   PPDB:244;   Pesticides:dimethoate;   Reaxys:1785339;   Wikipedia:Dimethoate


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dimethoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions
decreases expression
affects activity		 ISO
EXP		 Dimethoate results in decreased activity of ACHE protein
pralidoxime inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]
Acetylcysteine inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]
Dimethoate results in decreased expression of ACHE protein
Dimethoate affects the activity of ACHE protein		 CTD PMID:3247000 PMID:15033006 PMID:16112538 PMID:16112789 PMID:16701032 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases phosphorylation ISO Dimethoate results in decreased phosphorylation of AKT2 protein CTD PMID:23994500 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Alb albumin increases response to substance
multiple interactions		 ISO ALB protein results in increased susceptibility to Dimethoate
ALB protein promotes the reaction [Zinc Oxide binds to Dimethoate]		 CTD PMID:27441385 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of ALDH2 mRNA; [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in decreased expression of and results in decreased activity of ALDH2 protein CTD PMID:34830855 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Dimethoate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO
EXP		 Dimethoate results in decreased activity of BCHE protein CTD PMID:19793545 PMID:24052565 PMID:26482405 PMID:27441385 PMID:30243730 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cat catalase multiple interactions
increases expression
increases activity
decreases activity		 EXP
ISO		 [Dimethoate co-treated with Malathion] results in increased activity of CAT protein; [Phorate co-treated with acephate co-treated with Dichlorvos co-treated with Dimethoate] results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Dimethoate results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Dimethoate results in increased activity of CAT protein]
Dimethoate results in increased expression of CAT protein
Ascorbic Acid inhibits the reaction [Dimethoate results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Dimethoate results in increased activity of CAT protein]		 CTD PMID:11834209 PMID:16112789 PMID:20077558 PMID:22034174 PMID:26482405 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Dimethoate results in increased expression of CCL2 mRNA CTD PMID:23397585 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd86 CD86 molecule increases expression ISO Dimethoate results in increased expression of CD86 protein CTD PMID:23994500 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression EXP Dimethoate results in decreased expression of CHRM1 mRNA; Dimethoate results in decreased expression of CHRM1 protein CTD PMID:14694657 PMID:15033006 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases expression EXP Dimethoate results in decreased expression of CHRM2 mRNA; Dimethoate results in decreased expression of CHRM2 protein CTD PMID:14694657 PMID:15033006 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases expression
decreases expression		 ISO
EXP		 Dimethoate results in increased expression of CHRM3 mRNA
Dimethoate results in decreased expression of CHRM3 mRNA		 CTD PMID:15033005 PMID:15033006 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Cnst consortin, connexin sorting protein increases expression ISO Dimethoate results in increased expression of CNST mRNA CTD PMID:23397585 NCBI chr13:91,296,740...91,373,531
Ensembl chr13:91,296,142...91,373,531 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions		 ISO Dimethoate results in increased expression of CXCL10 mRNA
Estradiol inhibits the reaction [Dimethoate results in increased expression of CXCL10 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of CXCL10 mRNA]]		 CTD PMID:23943137 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases activity
multiple interactions
decreases expression		 ISO
EXP		 Dimethoate results in decreased activity of CYP11A1 protein
Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of CYP11A1 mRNA]		 CTD PMID:11054639 PMID:26769589 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO Dimethoate results in increased expression of CYP19A1 mRNA CTD PMID:23943137 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 increases expression EXP Dimethoate results in increased expression of CYP2D1 mRNA CTD PMID:25967365 NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity
increases expression		 ISO Dimethoate results in decreased activity of ESR1 protein
Dimethoate results in increased expression of ESR1 protein		 CTD PMID:22562034 PMID:23943137 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO Dimethoate results in increased expression of ESR2 mRNA CTD PMID:23943137 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Dimethoate results in increased expression of FSHB protein CTD PMID:19579042 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Dimethoate results in increased activity of G6PDX protein CTD PMID:16112789 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Dimethoate results in increased expression of GFAP mRNA; Dimethoate results in increased expression of GFAP protein CTD PMID:21941777 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression EXP Dimethoate results in increased expression of GSR protein CTD PMID:16112789 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 increases expression ISO Dimethoate results in increased expression of GULP1 mRNA CTD PMID:23397585 NCBI chr 9:46,622,699...46,899,005
Ensembl chr 9:46,622,669...46,899,005 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein CTD PMID:34830855 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression		 EXP Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of HSD17B3 mRNA] CTD PMID:26769589 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554 		JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 multiple interactions
decreases expression		 EXP Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of HSD3B3 mRNA] CTD PMID:26769589 NCBI chr 2:186,138,044...186,144,024
Ensembl chr 2:186,138,044...186,144,033 		JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO Dimethoate results in decreased expression of ID3 mRNA CTD PMID:23397585 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Il10 interleukin 10 decreases secretion ISO Dimethoate results in decreased secretion of IL10 protein CTD PMID:23994500 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta increases secretion
increases expression
multiple interactions		 ISO Dimethoate results in increased secretion of IL1B protein
Dimethoate results in increased expression of IL1B mRNA
Estradiol inhibits the reaction [Dimethoate results in increased expression of IL1B mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of IL1B mRNA]]		 CTD PMID:23943137 PMID:23994500 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO Dimethoate affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Estradiol inhibits the reaction [Dimethoate results in increased expression of IL6 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of IL6 mRNA]] CTD PMID:23891859 PMID:23943137 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Klf9 KLF transcription factor 9 increases expression ISO Dimethoate results in increased expression of KLF9 mRNA CTD PMID:23397585 NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037 		JBrowse link
G Kmo kynurenine 3-monooxygenase decreases activity EXP Dimethoate results in decreased activity of KMO protein CTD PMID:2119399 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881 		JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP Dimethoate results in decreased activity of KYAT1 protein CTD PMID:2119399 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
multiple interactions
increases expression		 ISO
EXP		 Dimethoate results in decreased expression of LHB protein
rofecoxib inhibits the reaction [Dimethoate results in increased expression of LHB protein]		 CTD PMID:19579042 PMID:19726577 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Dimethoate results in decreased phosphorylation of MAPK1 protein CTD PMID:23994500 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO Dimethoate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Dimethoate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:29149346 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Pdxk pyridoxal kinase decreases activity EXP
ISO		 Dimethoate results in decreased activity of PDXK protein CTD PMID:2119399 PMID:2547861 NCBI chr20:10,210,276...10,232,314
Ensembl chr20:10,210,289...10,232,110 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP Dimethoate results in increased expression of PTGS2 protein
[Dimethoate co-treated with Eicosapentaenoic Acid] results in increased expression of PTGS2 protein; Docosahexaenoic Acids inhibits the reaction [Dimethoate results in increased expression of PTGS2 protein]; docosapentaenoic acid inhibits the reaction [Dimethoate results in increased expression of PTGS2 protein]		 CTD PMID:19579042 PMID:22476691 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G S100b S100 calcium binding protein B increases expression EXP Dimethoate results in increased expression of S100B mRNA; Dimethoate results in increased expression of S100B protein CTD PMID:21941777 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
increases expression
multiple interactions		 ISO
EXP		 Dimethoate results in decreased expression of STAR mRNA
Dimethoate results in increased expression of STAR mRNA
Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of STAR mRNA]; Arachidonic Acid inhibits the reaction [Dimethoate results in decreased expression of STAR protein]; Eicosapentaenoic Acid promotes the reaction [Dimethoate results in decreased expression of STAR protein]
Dimethoate results in decreased expression of STAR mRNA; Dimethoate results in decreased expression of STAR protein		 CTD PMID:11054639 PMID:19579042 PMID:22476691 PMID:23943137 PMID:26769589 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tbx3 T-box transcription factor 3 increases expression ISO Dimethoate results in increased expression of TBX3 mRNA CTD PMID:23397585 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity ISO Dimethoate results in decreased activity of TDO2 protein CTD PMID:2547861 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
G Tgoln2 trans-golgi network protein 2 increases expression ISO Dimethoate results in increased expression of TGOLN2 mRNA CTD PMID:23397585 NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Dimethoate results in increased expression of TNF mRNA
Estradiol inhibits the reaction [Dimethoate results in increased expression of TNF mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of TNF mRNA]]		 CTD PMID:23891859 PMID:23943137 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
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  CHEBI ontology 19922
    role 19894
      application 19735
        agrochemical 16890
          dimethoate 45
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbon oxoacid 18694
                                    carboxylic acid 18691
                                      carboacyl group 17723
                                        univalent carboacyl group 17723
                                          carbamoyl group 17576
                                            carboxamide 17576
                                              acetamides 14643
                                                acetamide 8761
                                                  N-methyl-2-sulfanylacetamide 55
                                                    dimethoate 45
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