Term: | compactin diol lactone |
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Accession: | CHEBI:34652
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Definition: | A carbobicyclic compound that is ML-236C substituted by a hydroxy group at position 8S. It is a fungal metabolite isolated from Penicillium citrinum and exhibits anticholesteremic activity. |
Synonyms: | exact_synonym: | (4R,6R)-4-hydroxy-6-{2-[(1S,2S,8S,8aR)-8-hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl}tetrahydro-2H-pyran-2-one |
| related_synonym: | (4R,6R)-4-hydroxy-6-{2-[(1S,2S,8S,8aR)-8-hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl}oxan-2-one; Antibiotic ML 236A; Formula=C18H26O4; InChI=1S/C18H26O4/c1-11-5-6-12-3-2-4-16(20)18(12)15(11)8-7-14-9-13(19)10-17(21)22-14/h3,5-6,11,13-16,18-20H,2,4,7-10H2,1H3/t11-,13+,14+,15-,16-,18-/m0/s1; InChIKey=WWSNTLOVYSRDEL-DZSDEGEFSA-N; ML-236A; SMILES=C1CC=C2[C@]([C@H]1O)([C@H]([C@H](C=C2)C)CC[C@H]3OC(C[C@@H](C3)O)=O)[H]; desmethylmonacolin J |
| xref: | CAS:58889-19-3; KEGG:C14183; KNApSAcK:C00018116; PMID:1010803; PMID:12929390; PMID:15531273; PMID:16386050; PMID:2280672; PMID:2696346; PMID:28619444; PMID:3793626; PMID:6549610; PMID:908337 |
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