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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:argipressin
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Accession:CHEBI:34543 term browser browse the term
Definition:The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.
Synonyms:exact_synonym: 1-{[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-arginylglycinamide
 related_synonym: 8-Arginine-vasopressin;   8-L-arginine-vasopressin;   ADH;   AVP;   Arg-vasopressin;   Argipressin tannate;   Formula=C46H65N15O12S2;   InChI=1S/C46H65N15O12S2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33?,34-/m0/s1;   InChIKey=KBZOIRJILGZLEJ-LGYYRGKSSA-N;   SMILES=N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O;   Vasopressin (arginine form);   [Arg8]-vasopressin;   [cyclo S-S]CYFQNCPRG-NH2;   arginine vasopressin;   argipresina;   argipressine;   argipressinum
 alt_id: CHEBI:59901
 xref: CAS:113-79-1;   Drug_Central:2810;   KEGG:C13662;   KEGG:D02983
 xref_mesh: MESH:D001127
 xref: PMID:741201;   PMID:8385171;   Reaxys:10773460;   Wikipedia:Vasopressin
 cyclic_relationship: is_conjugate_base_of CHEBI:194507


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argipressin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr1a arginine vasopressin receptor 1A multiple interactions
increases activity		 ISO vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine- inhibits the reaction [Arginine Vasopressin results in increased activity of AVPR1A protein] CTD PMID:31323226 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression
multiple interactions		 EXP Arginine Vasopressin results in increased expression of HSPB1 mRNA; Arginine Vasopressin results in increased expression of HSPB1 protein
Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 mRNA]; Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 protein]		 CTD PMID:10839933 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
multiple interactions		 EXP Arginine Vasopressin results in increased activity of MAPK1 protein
4'-(4,4-difluoro-5-(2-oxo-2-(4-piperidinopiperidino)ethylidene)-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-methyl-3-furanilide inhibits the reaction [Arginine Vasopressin results in increased activity of MAPK1 protein]		 CTD PMID:16966841 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Myl9 myosin light chain 9 increases phosphorylation EXP Arginine Vasopressin results in increased phosphorylation of MYL9 protein CTD PMID:15347643 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Nppa natriuretic peptide A decreases response to substance ISO NPPA protein results in decreased susceptibility to Arginine Vasopressin CTD PMID:8188982 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        mitogen 3508
          argipressin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17550
                                            carboxamide 17550
                                              peptide 11442
                                                cyclic peptide 8925
                                                  heterodetic cyclic peptide 1720
                                                    vasopressin 7
                                                      argipressin 5
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