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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:8,9-EET
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Accession:CHEBI:34490 term browser browse the term
Definition:An EET obtained by formal epoxidation of the 8,9-double bond of arachidonic acid.
Synonyms:exact_synonym: (5Z)-7-{3-[(2Z,5Z)-undeca-2,5-dien-1-yl]oxiran-2-yl}hept-5-enoic acid
 related_synonym: (+/-)8,9-EpETrE;   (5Z,11Z,14Z)-8,9-Epoxyeicosa-5,11,14-trienoic acid;   (5Z,11Z,14Z)-8,9-Epoxyicosa-5,11,14-trienoic acid;   8,9-Epoxyeicosatrienoic acid;   8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid;   8,9-epoxy-5Z,11Z,14Z-icosatrienoic acid;   8,9-epoxyicosatrienoic acid;   Formula=C20H32O3;   InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-12-15-18-19(23-18)16-13-10-11-14-17-20(21)22/h6-7,9-10,12-13,18-19H,2-5,8,11,14-17H2,1H3,(H,21,22)/b7-6-,12-9-,13-10-;   InChIKey=DBWQSCSXHFNTMO-TYAUOURKSA-N;   SMILES=CCCCC\\C=C/C\\C=C/CC1OC1C\\C=C/CCCC(O)=O
 alt_id: CHEBI:63972
 xref: HMDB:HMDB0002232;   KEGG:C14769;   LIPID_MAPS_instance:LMFA03080003
 xref_mesh: MESH:C050715
 xref: Reaxys:4697201
 cyclic_relationship: is_conjugate_acid_of CHEBI:84025


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8,9-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis		 ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid] CTD PMID:12675279 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ephx1 epoxide hydrolase 1 affects hydrolysis ISO EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid CTD PMID:28975360 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid CTD PMID:19896470 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          metabolite 19562
            EET 13
              8,9-EET 3
                (8R,9S)-EET 0
                (8S,9R)-EET 0
                8(9)-EET methyl ester 0
                8,9-epoxy-(5Z,11Z,14Z)-icosatrienoyl-CoA 0
                N-[(5Z,11Z,14Z)-8,9-epoxyicosatrienoyl]ethanolamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbon oxoacid 18681
                                    carboxylic acid 18678
                                      monocarboxylic acid 18024
                                        fatty acid 16829
                                          unsaturated fatty acid 1670
                                            polyunsaturated fatty acid 847
                                              fatty acid 20:4 364
                                                icosatetraenoic acid 364
                                                  icosa-5,8,11,14-tetraenoic acid 321
                                                    arachidonic acid 321
                                                      EET 13
                                                        8,9-EET 3
                                                          (8R,9S)-EET 0
                                                          (8S,9R)-EET 0
                                                          8(9)-EET methyl ester 0
                                                          8,9-epoxy-(5Z,11Z,14Z)-icosatrienoyl-CoA 0
                                                          N-[(5Z,11Z,14Z)-8,9-epoxyicosatrienoyl]ethanolamine 0
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