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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-chloro-3,5-dimethylphenol
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Accession:CHEBI:34393 term browser browse the term
Definition:A member of the class of phenols that is 3,5-xylenol which is substituted at position 4 by chlorine. It is bactericidal against most Gram-positive bacteria but less effective against Staphylococci and Gram-negative bacteria, and often inactive against Pseudomonas species. It is ineffective against bacterial spores.
Synonyms:related_synonym: 2-Chloro-m-xylenol;   2-chloro-5-hydroxy-1,3-dimethylbenzene;   2-chloro-5-hydroxy-m-xylene;   3,5-dimethyl-4-chlorophenol;   4-chloro-1-hydroxy-3,5-dimethylbenzene;   4-chloro-m-xylenol;   Benzytol;   Dettol;   PCMX;   chloro-xylenol;   chloroxylenol;   chloroxylenolum;   cloroxilenol;   p-chloro-3,5-xylenol;   p-chloro-m-xylenol;   parachlorometaxylenol;   parametaxylenol
 xref: CAS:88-04-0
 xref_mesh: MESH:C007027
 xref: PPDB:1615;   Patent:US2350677;   Reaxys:1862539;   VSDB:1615;   drugcentral:3094;   kegg.compound:C14715;   kegg.drug:D03473;   lincs.smallmolecule:LSM-19962;   pubmed:12927380;   pubmed:15167195;   pubmed:1608902;   pubmed:17498419;   pubmed:19818989;   pubmed:21860168;   pubmed:22865169;   pubmed:27316554;   pubmed:27857768;   pubmed:28531838;   pubmed:3855184;   pubmed:6283866;   pubmed:7779444;   pubmed:8066978;   pubmed:8265774;   pubmed:8272409;   pubmed:8906435;   pubmed:9124667;   wikipedia.en:Chloroxylenol
 chemrof_formula: C8H9ClO
 chemrof_smiles: Cc1cc(O)cc(C)c1Cl
 chemrof_inchi: InChI=1S/C8H9ClO/c1-5-3-7(10)4-6(2)8(5)9/h3-4,10H,1-2H3
 chemrof_inchikey: OSDLLIBGSJNGJE-UHFFFAOYSA-N
 cyclic_relationship: has_functional_parent CHEBI:38572


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4-chloro-3,5-dimethylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO chloroxylenol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO chloroxylenol binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO chloroxylenol binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO chloroxylenol binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO chloroxylenol binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 affects activity
multiple interactions 		ISO chloroxylenol affects the activity of SCN4A protein polymorphism
chloroxylenol binds to and results in decreased activity of SCN4A protein 		CTD PMID:11282107 PMID:14662728 NCBI chr10:91,745,459...91,796,452
Ensembl chr10:91,746,715...91,796,324 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO chloroxylenol binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        pesticide 18454
          molluscicide 1559
            4-chloro-3,5-dimethylphenol 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                carbocyclic compound 18739
                                  benzenoid aromatic compound 17899
                                    benzenes 17656
                                      chlorobenzenes 15281
                                        monochlorobenzenes 12256
                                          4-chloro-3,5-dimethylphenol 7
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