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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-aminopyridine
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Accession:CHEBI:34385 term browser browse the term
Definition:An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.
Synonyms:exact_synonym: pyridin-4-amine
 related_synonym: 4-AP;   4-Pyridinamine;   4-Pyridylamine;   Ampyra;   Avitrol;   Dalfampridine;   Fampridine;   Formula=C5H6N2;   InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7);   InChIKey=NUKYPUAOHBNCPY-UHFFFAOYSA-N;   N07XX07;   SMILES=Nc1ccncc1;   fampridina;   fampridinum;   gamma-Aminopyridine;   p-Aminopyridine
 xref: CAS:504-24-5;   Drug_Central:4163;   KEGG:C13728;   KEGG:D04127
 xref_mesh: MESH:D015761
 xref: PDBeChem:4AP;   PMID:11049865;   PMID:12509600;   PMID:12525889;   PMID:12853442;   PMID:12860480;   PMID:14585815;   PMID:14970964;   PMID:15052305;   PMID:15202573;   PMID:15678081;   PMID:16088375;   PMID:16417531;   PMID:16567254;   PMID:16806301;   PMID:17014896;   PMID:17071731;   PMID:17629412;   PMID:18394011;   PMID:19302905;   PMID:19443164;   PMID:19542906;   PMID:19818752;   PMID:19915712;   PMID:19966074;   PMID:20044444;   PMID:20112006;   PMID:20473651;   PMID:20967295;   PMID:21573085;   PMID:21694807;   PMID:22000073;   PMID:22073939;   PMID:22135060;   PMID:22497693;   PMID:22703551;   PMID:22936332;   PMID:23077091;   PMID:23146002;   PMID:7507992;   PMID:8208758;   PMID:8569870;   PMID:8599505;   PMID:8813586;   PMID:9178370;   PPDB:1348;   Reaxys:105782;   Wikipedia:Dalfampridine


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4-aminopyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1b adrenoceptor alpha 1B multiple interactions EXP 4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine] CTD PMID:18480251 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP 4-Aminopyridine results in increased expression of BAX mRNA CTD PMID:24378259 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression EXP 4-Aminopyridine results in decreased expression of BIRC2 mRNA CTD PMID:24378259 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression EXP 4-Aminopyridine results in decreased expression of BIRC3 mRNA CTD PMID:24378259 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Bmf Bcl2 modifying factor increases expression EXP 4-Aminopyridine results in increased expression of BMF mRNA CTD PMID:24378259 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145 		JBrowse link
G C5h1orf159 similar to human chromosome 1 open reading frame 159 increases expression EXP 4-Aminopyridine results in increased expression of C1ORF159 mRNA CTD PMID:24378259 NCBI chr 5:166,701,485...166,719,939
Ensembl chr 5:166,701,676...166,719,955 		JBrowse link
G Casp3 caspase 3 increases activity EXP 4-Aminopyridine results in increased activity of CASP3 protein CTD PMID:24378259 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity EXP 4-Aminopyridine results in increased activity of CASP7 protein CTD PMID:24378259 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases activity EXP 4-Aminopyridine results in increased activity of CASP9 protein CTD PMID:24378259 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cd40 CD40 molecule increases expression EXP 4-Aminopyridine results in increased expression of CD40 mRNA CTD PMID:24378259 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand increases expression EXP 4-Aminopyridine results in increased expression of CD40LG mRNA CTD PMID:24378259 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Ctsb cathepsin B increases expression EXP 4-Aminopyridine results in increased expression of CTSB mRNA CTD PMID:24378259 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 increases expression EXP 4-Aminopyridine results in increased expression of DPYSL4 mRNA CTD PMID:24378259 NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914 		JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression
multiple interactions		 EXP 4-Aminopyridine results in increased expression of GAD2 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA]		 CTD PMID:25917026 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 decreases expression EXP 4-Aminopyridine results in decreased expression of GALNT5 mRNA CTD PMID:24378259 NCBI chr 3:42,573,622...42,619,881
Ensembl chr 3:42,573,622...42,619,881 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D multiple interactions ISO [Bicuculline co-treated with 4-Aminopyridine] results in decreased expression of GRIN2D protein CTD PMID:19911010 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793 		JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions EXP [Bicuculline co-treated with 4-Aminopyridine] affects the localization of HDAC5 protein CTD PMID:15773917 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Jph3 junctophilin 3 increases expression EXP 4-Aminopyridine results in increased expression of JPH3 mRNA CTD PMID:24378259 NCBI chr19:49,793,967...49,855,338
Ensembl chr19:49,793,092...49,855,338 		JBrowse link
G Kcna10 potassium voltage-gated channel subfamily A member 10 multiple interactions ISO 4-Aminopyridine inhibits the reaction [KCNA10 protein results in increased transport of Potassium] CTD PMID:10836990 NCBI chr 2:194,786,500...194,798,575
Ensembl chr 2:194,786,500...194,798,575 		JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 increases expression
multiple interactions		 EXP 4-Aminopyridine results in increased expression of KCND3 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA]		 CTD PMID:25917026 NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO 4-Aminopyridine results in decreased activity of KCNH2 protein CTD PMID:19915712 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnip1 potassium voltage-gated channel interacting protein 1 decreases expression
increases expression
multiple interactions		 EXP 4-Aminopyridine results in decreased expression of KCNIP1 mRNA
4-Aminopyridine results in increased expression of KCNIP1 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased abundance of gamma-Aminobutyric Acid]; KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA]; KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA]		 CTD PMID:24378259 PMID:25917026 NCBI chr10:18,219,519...18,588,833
Ensembl chr10:18,219,519...18,589,045 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 decreases expression ISO 4-aminopyridine decreases expression of KCNN4 mRNA and protein in CD4-positive alpha-beta T cell RGD PMID:26502942 RGD:329955577 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Mag myelin-associated glycoprotein decreases expression EXP 4-Aminopyridine results in decreased expression of MAG mRNA CTD PMID:24378259 NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression EXP 4-Aminopyridine results in increased expression of MAP1LC3A mRNA CTD PMID:24378259 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 [Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein]
4-Aminopyridine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; [4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK1 protein; ciproxifan inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK1 protein]		 CTD PMID:19911010 PMID:22759588 PMID:28132918 PMID:33621091 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 [Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein]
4-Aminopyridine results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; [4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK3 protein; ciproxifan inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK3 protein]		 CTD PMID:19911010 PMID:22759588 PMID:28132918 PMID:33621091 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]; [Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein] CTD PMID:15773917 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases phosphorylation
multiple interactions		 EXP 4-Aminopyridine results in increased phosphorylation of PRKACA protein
lappaconitine inhibits the reaction [4-Aminopyridine results in increased phosphorylation of PRKACA protein]		 CTD PMID:35643327 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions EXP [Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]] CTD PMID:15773917 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G S100a7a S100 calcium binding protein A7A decreases expression EXP 4-Aminopyridine results in decreased expression of S100A7A mRNA CTD PMID:24378259 NCBI chr 2:176,151,405...176,155,846
Ensembl chr 2:176,151,288...176,156,441 		JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions
increases phosphorylation		 EXP lappaconitine inhibits the reaction [4-Aminopyridine results in increased phosphorylation of SNAP25 protein] CTD PMID:35643327 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Syn1 synapsin I affects response to substance
multiple interactions
increases response to substance
increases expression		 ISO
EXP		 SYN1 protein affects the susceptibility to 4-Aminopyridine
[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of SYN1 protein; ciproxifan inhibits the reaction [4-Aminopyridine results in increased expression of SYN1 protein modified form]; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of SYN1 protein]
SYN1 results in increased susceptibility to 4-Aminopyridine		 CTD PMID:22759588 PMID:28132918 PMID:33621091 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 increases expression EXP 4-Aminopyridine results in increased expression of TRAF2 mRNA CTD PMID:24378259 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
torasemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases expression EXP Torsemide results in increased expression of AGT protein modified form CTD PMID:18154949 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects expression EXP Torsemide affects the expression of CYP11B2 protein CTD PMID:18001696 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects metabolic processing EXP CYP2C11 protein affects the metabolism of Torsemide CTD PMID:15890479 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
multiple interactions		 ISO CYP2C8 protein results in increased metabolism of Torsemide
Torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein]		 CTD PMID:15304522
G Nppa natriuretic peptide A decreases expression EXP Torsemide results in decreased expression of NPPA protein CTD PMID:18154949 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions EXP Torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein] CTD PMID:7954537 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Ren renin increases expression EXP Torsemide results in increased expression of REN protein CTD PMID:7954537 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 decreases activity
multiple interactions		 ISO Torsemide results in decreased activity of SLC12A2 protein
Torsemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]		 CTD PMID:29959396 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
affects expression		 EXP Torsemide results in decreased expression of TGFB1 protein
Torsemide affects the expression of TGFB1 protein		 CTD PMID:18001696 PMID:18154949 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pesticide 18062
          avicide 5553
            4-aminopyridine 43
              4-aminonicotinic acid 0
              4-aminopyridine-3-methanol 0
              torasemide + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        aromatic amine 15478
                                          aminopyridine 516
                                            4-aminopyridine 43
                                              4-aminonicotinic acid 0
                                              4-aminopyridine-3-methanol 0
                                              torasemide + 9
paths to the root