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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,4-dibromophenol
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Accession:CHEBI:34238 term browser browse the term
Definition:A bromophenol that is phenol in which the hydrogens at positions 2 and 4 have been replaced by bromines.
Synonyms:related_synonym: 2,4-DBP;   Formula=C6H4Br2O;   InChI=1S/C6H4Br2O/c7-4-1-2-6(9)5(8)3-4/h1-3,9H;   InChIKey=FAXWFCTVSHEODL-UHFFFAOYSA-N;   SMILES=C1=CC(=CC(=C1O)Br)Br
 xref: AGR:IND44086700;   CAS:615-58-7;   FooDB:FDB008794;   HMDB:HMDB0032079;   KEGG:C14521;   KNApSAcK:C00033541
 xref_mesh: MESH:C013930
 xref: PMID:16911838;   PMID:19664797;   PMID:20065618;   PMID:21459404;   PMID:22697042;   PMID:23786809;   PMID:25229997;   PMID:25817024;   PMID:26295539;   PMID:26602791;   PMID:27085014;   PMID:28893619;   PMID:29191314;   Reaxys:1861291;   Wikipedia:2\,4-Dibromophenol


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2,4-dibromophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression
multiple interactions		 ISO 2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form
Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; TRP53 inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]		 CTD PMID:33961949 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein]; TRP53 promotes the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein] CTD PMID:33961949 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO 2,4-dibromophenol results in increased expression of CYP11A1 mRNA CTD PMID:17447562 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO 2,4-dibromophenol results in increased expression of CYP11B2 mRNA CTD PMID:17447562 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO 2,4-dibromophenol results in increased expression of CYP17A1 mRNA CTD PMID:17447562 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO 2,4-dibromophenol results in increased expression of CYP19A1 mRNA CTD PMID:17447562 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; TRP53 inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form] CTD PMID:33961949 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO 2,4-dibromophenol results in increased expression of HMGCR mRNA CTD PMID:17447562 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 increases expression ISO 2,4-dibromophenol results in increased expression of HSD17B1 mRNA CTD PMID:17447562 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO 2,4-dibromophenol results in increased expression of HSD17B4 mRNA CTD PMID:17447562 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression ISO 2,4-dibromophenol results in increased expression of HSD3B2 mRNA CTD PMID:17447562 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO 2,4-dibromophenol results in increased expression of STAR mRNA CTD PMID:17447562 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO 2,4-dibromophenol metabolite results in increased expression of and affects the localization of TRP53 protein; Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of TRP53 protein modified form]; Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of TRP53 protein]; TRP53 inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; TRP53 inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; TRP53 promotes the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein] CTD PMID:33961949 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ttr transthyretin affects binding ISO 2,4-dibromophenol binds to TTR protein CTD PMID:10869457 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        flame retardant 10554
          brominated flame retardant 4889
            2,4-dibromophenol 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                carbocyclic compound 18584
                                  benzenoid aromatic compound 18008
                                    benzenes 17873
                                      bromobenzenes 5126
                                        bromophenol 1170
                                          2,4-dibromophenol 14
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