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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene
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Accession:CHEBI:34211 term browser browse the term
Definition:A diarylmethane that has formula C14H8Cl4.
Synonyms:related_synonym: 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethylene;   2,4'-DDE;   Formula=C14H8Cl4;   InChI=1S/C14H8Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8H;   InChIKey=ZDYJWDIWLRZXDB-UHFFFAOYSA-N;   SMILES=ClC(Cl)=C(c1ccc(Cl)cc1)c1ccccc1Cl;   o,p'-DDE
 xref: CAS:3424-82-6;   KEGG:C14133
 xref_mesh: MESH:C054919


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2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1c activin A receptor type 1C multiple interactions ISO [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ACVR1C mRNA CTD PMID:19422813 NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327 		JBrowse link
G Acvrl1 activin A receptor like type 1 multiple interactions ISO [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ACVRL1 mRNA CTD PMID:19422813 NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of AHR protein CTD PMID:32721735 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Alk ALK receptor tyrosine kinase multiple interactions ISO [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ALK mRNA CTD PMID:19422813 NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034 		JBrowse link
G Ar androgen receptor multiple interactions
affects binding		 ISO
EXP		 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene binds to and results in decreased activity of AR protein; 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Dihydrotestosterone binds to AR protein]; 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Metribolone results in increased activity of AR protein]
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene binds to AR protein		 CTD PMID:9705896 PMID:14565775 PMID:14579009 PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO ATG7 protein affects the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein] CTD PMID:32721735 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of BECN1 mRNA
BECN1 protein affects the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]		 CTD PMID:32721735 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein
ATG7 protein affects the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]; BECN1 protein affects the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]; diazepinylbenzoic acid inhibits the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]; ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate inhibits the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]; RXRA mRNA promotes the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]; RXRB mRNA promotes the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]		 CTD PMID:26563996 PMID:32721735 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Crebbp CREB binding protein increases activity ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CREBBP protein CTD PMID:22609851 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions ISO [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ERBB3 mRNA CTD PMID:19422813 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions		 ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene binds to ESR1 protein
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Estradiol binds to ESR1 protein]		 CTD PMID:14579009 PMID:19913605 PMID:32278787 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 affects binding ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene binds to GPER1 protein CTD PMID:17088055 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of KIT mRNA CTD PMID:19422813 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of MAP1LC3A mRNA; 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of MAP1LC3A protein CTD PMID:32721735 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta affects expression ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene affects the expression of MAP1LC3B mRNA CTD PMID:32721735 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity
increases expression
affects expression		 ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of NR1I3 protein
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of NR1I3 protein
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene affects the expression of NR1I3 mRNA		 CTD PMID:28927721 PMID:32721735 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nup62 nucleoporin 62 increases expression
affects expression		 ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of NUP62 protein
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene affects the expression of NUP62 mRNA		 CTD PMID:32721735 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha multiple interactions ISO [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRA mRNA CTD PMID:19422813 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRB mRNA CTD PMID:19422813 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pgr progesterone receptor affects binding
multiple interactions		 ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene binds to PGR protein
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Progesterone binds to PGR protein]; 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene inhibits the reaction [Progesterone results in increased expression of PGR protein]		 CTD PMID:14579009 PMID:18262749 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of PTGS2 protein CTD PMID:23132776 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rarb retinoic acid receptor, beta affects binding ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene binds to RARB protein CTD PMID:32278787 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
increases expression		 ISO RXRA mRNA promotes the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of RXRA mRNA; 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of RXRA protein		 CTD PMID:26563996 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Rxrb retinoid X receptor beta increases expression
multiple interactions		 ISO 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of RXRB mRNA; 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of RXRB protein
RXRB mRNA promotes the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]		 CTD PMID:26563996 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773 		JBrowse link
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  CHEBI ontology 19922
    chemical entity 19920
      group 19878
        polyatomic entity 19877
          molecule 19770
            cyclic compound 19535
              organic cyclic compound 19545
                organic aromatic compound 19380
                  diarylmethane 9457
                    2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene 24
Path 2
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  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      p-block molecular entity 19866
                        carbon group molecular entity 19805
                          organic molecular entity 19775
                            organic molecule 19755
                              organic cyclic compound 19545
                                organic aromatic compound 19380
                                  diarylmethane 9457
                                    2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene 24
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