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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,2',4,4'-tetrachlorobiphenyl
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Accession:CHEBI:34204 term browser browse the term
Definition:A tetrachlorobiphenyl that is biphenyl in which each of the phenyl groups is substituted at positions 2 and 4 by chlorines.
Synonyms:related_synonym: 1,1'-Biphenyl, 2,2',4,4'-tetrachloro-;   2,2',4,4'-Tetrachlorodiphenyl;   Formula=C12H6Cl4;   InChI=1S/C12H6Cl4/c13-7-1-3-9(11(15)5-7)10-4-2-8(14)6-12(10)16/h1-6H;   InChIKey=QORAVNMWUNPXAO-UHFFFAOYSA-N;   PCB 47;   SMILES=Clc1ccc(c(Cl)c1)-c1ccc(Cl)cc1Cl
 xref: Beilstein:2052543;   CAS:2437-79-8;   KEGG:C14247
 xref_mesh: MESH:C035976


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2,2',4,4'-tetrachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding
multiple interactions		 EXP
ISO		 2,4,2',4'-tetrachlorobiphenyl binds to AR protein
[aroclor 1260 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with 2,4,4'-trichlorobiphenyl co-treated with 2,4,2',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,3',4'-tetrachlorobiphenyl] inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]		 CTD PMID:14565775 PMID:21295777 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:20861069 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:20861069 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO 2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; 2,4,2',4'-tetrachlorobiphenyl promotes the reaction [3,5-dibromo-2-(2,4-dibromophenoxy)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,2',4'-tetrachlorobiphenyl promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; 2,4,4'-trichlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; [2,4,2',4'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; PCB 180 inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:20819908 PMID:20861069 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO 2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; 2,4,2',4'-tetrachlorobiphenyl promotes the reaction [3,5-dibromo-2-(2,4-dibromophenoxy)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,2',4'-tetrachlorobiphenyl promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; 2,4,4'-trichlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; [2,4,2',4'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; PCB 180 inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:20819908 PMID:20861069 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO 2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; 2,4,2',4'-tetrachlorobiphenyl promotes the reaction [3,5-dibromo-2-(2,4-dibromophenoxy)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,2',4'-tetrachlorobiphenyl promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; 2,4,4'-trichlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; [2,4,2',4'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; PCB 180 inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:20819908 PMID:20861069 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO
EXP		 2,4,2',4'-tetrachlorobiphenyl results in increased phosphorylation of MAPK1 protein CTD PMID:19751709 PMID:20171977 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO
EXP		 2,4,2',4'-tetrachlorobiphenyl results in increased phosphorylation of MAPK3 protein CTD PMID:19751709 PMID:20171977 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases phosphorylation ISO 2,4,2',4'-tetrachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mpo myeloperoxidase increases secretion ISO 2,4,2',4'-tetrachlorobiphenyl results in increased secretion of MPO protein CTD PMID:15673847 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO 2,4,2',4'-tetrachlorobiphenyl results in increased activity of NR1I2 protein CTD PMID:25680588 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein] CTD PMID:21782008 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO 2,4,2',4'-tetrachlorobiphenyl results in increased expression of PTGS2 mRNA
2,4,2',4'-tetrachlorobiphenyl results in increased expression of and results in increased activity of PTGS2 protein		 CTD PMID:15673847 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      chemical role 19479
        environmental contaminant 18858
          persistent organic pollutant 16771
            polychlorobiphenyl 6031
              tetrachlorobiphenyl 2419
                2,2',4,4'-tetrachlorobiphenyl 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            organic hydride 18691
                              organic fundamental parent 18691
                                hydrocarbon 18442
                                  halohydrocarbon 15851
                                    haloarene 6418
                                      chloroarene 6033
                                        chlorobiphenyl 6033
                                          polychlorobiphenyl 6031
                                            tetrachlorobiphenyl 2419
                                              2,2',4,4'-tetrachlorobiphenyl 13
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