1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane	go back to main search page
Accession:	CHEBI:34027	browse the term
Definition:	A diarylmethane that has formula C14H9Cl5.
Synonyms:	related_synonym:	2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1,1-trichloroethane; Formula=C14H9Cl5; InChI=1S/C14H9Cl5/c15-10-7-5-9(6-8-10)13(14(17,18)19)11-3-1-2-4-12(11)16/h1-8,13H; InChIKey=CVUGPAFCQJIYDT-UHFFFAOYSA-N; SMILES=Clc1ccc(cc1)C(c1ccccc1Cl)C(Cl)(Cl)Cl; o,p'-DDT
	xref:	CAS:789-02-6; KEGG:C14187
	xref_mesh:	MESH:C016340
	xref:	PPDB:3141

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Genes (475)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

increases expression

EXP
ISO

o,p'-DDT results in increased expression of AARS1 mRNA

NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497

G

ATP binding cassette subfamily B member 1A

decreases activity
increases expression

ISO

o,p'-DDT results in decreased activity of ABCB1 protein
o,p'-DDT results in increased expression of ABCB1 mRNA

PMID:23169446 PMID:24464585

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 2

increases expression

ISO

o,p'-DDT results in increased expression of ABCC2 mRNA

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily G member 2

increases expression
decreases activity

ISO

o,p'-DDT results in increased expression of ABCG2 mRNA
o,p'-DDT results in decreased activity of ABCG2 protein

PMID:23169446 PMID:24464585

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

ADAM metallopeptidase with thrombospondin type 1 motif, 9

increases expression

ISO

o,p'-DDT results in increased expression of ADAMTS9 mRNA

NCBI chr 4:126,847,726...127,019,924
Ensembl chr 4:126,847,729...127,019,876

G

aryl hydrocarbon receptor

affects expression
multiple interactions
increases expression
decreases methylation

ISO

o,p'-DDT affects the expression of AHR mRNA
o,p'-DDT promotes the reaction [AHR protein binds to CYP1A1 promoter]
o,p'-DDT results in increased expression of AHR mRNA; o,p'-DDT results in increased expression of AHR protein
o,p'-DDT results in decreased methylation of AHR gene

PMID:12176094 PMID:18925944 PMID:28263910

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldo-keto reductase family 1, member C2

increases expression

ISO

o,p'-DDT results in increased expression of AKR1C2 mRNA

NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686

G

aldo-keto reductase family 7, member A2

affects expression

EXP

o,p'-DDT affects the expression of AKR7A2 mRNA

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:156,835,551...156,844,109

G

AKT serine/threonine kinase 1

increases phosphorylation

ISO

o,p'-DDT results in increased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

aldehyde dehydrogenase 1 family, member A1

affects expression

EXP

o,p'-DDT affects the expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

alpha-kinase 2

decreases expression

ISO

o,p'-DDT results in decreased expression of ALPK2 mRNA

NCBI chr18:61,045,717...61,161,703
Ensembl chr18:61,045,380...61,175,985

G

alkaline phosphatase, biomineralization associated

multiple interactions

ISO

o,p'-DDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

anaphase promoting complex subunit 1

increases expression

ISO

o,p'-DDT results in increased expression of ANAPC1 mRNA

NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:136,303,413...136,383,464

G

anoctamin 1

increases expression

ISO

o,p'-DDT results in increased expression of ANO1 mRNA

NCBI chr 1:209,180,755...209,329,413
Ensembl chr 1:209,180,755...209,329,550

G

adaptor-related protein complex 1 associated regulatory protein

increases expression

ISO

o,p'-DDT results in increased expression of AP1AR mRNA

NCBI chr 2:218,951,104...218,983,495
Ensembl chr 2:218,927,373...218,983,752

G

apoptotic peptidase activating factor 1

decreases expression

EXP

o,p'-DDT analog results in decreased expression of APAF1 mRNA

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

apoptosis inhibitor 5

decreases expression

EXP

o,p'-DDT analog results in decreased expression of API5 mRNA

NCBI chr 3:80,378,096...80,403,259
Ensembl chr 3:100,833,417...100,858,580

G

APAF1 interacting protein

decreases expression

EXP
ISO

o,p'-DDT results in decreased expression of APIP mRNA

NCBI chr 3:109,886,919...109,913,295
Ensembl chr 3:109,886,953...109,915,862

G

apolipoprotein A4

affects expression

ISO

o,p'-DDT affects the expression of APOA4 mRNA

NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164

G

amyloid beta precursor protein

affects expression

EXP

o,p'-DDT affects the expression of APP mRNA

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

aquaporin 8

increases expression

ISO
EXP

o,p'-DDT results in increased expression of AQP8 mRNA

NCBI chr 1:187,424,314...187,430,243
Ensembl chr 1:187,424,417...187,430,242

G

androgen receptor

multiple interactions
affects binding
decreases expression
decreases activity
increases expression

ISO
EXP

Dihydrotestosterone inhibits the reaction [o,p'-DDT results in increased activity of AR protein]; o,p'-DDT binds to and results in decreased activity of AR protein; o,p'-DDT inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to AR protein]; o,p'-DDT inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; o,p'-DDT inhibits the reaction [Metribolone results in increased activity of AR protein]
o,p'-DDT binds to AR protein
o,p'-DDT results in decreased expression of AR mRNA
o,p'-DDT results in decreased activity of AR protein
o,p'-DDT results in increased expression of AR mRNA

PMID:9705896 PMID:9846162 PMID:10822019 PMID:12676605 PMID:14565775 More...

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

arginase 1

multiple interactions

EXP

o,p'-DDT inhibits the reaction [Hydrocortisone results in increased expression of ARG1 mRNA]

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

aryl hydrocarbon receptor nuclear translocator

decreases expression

ISO

o,p'-DDT results in decreased expression of ARNT mRNA; o,p'-DDT results in decreased expression of ARNT protein

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

aryl hydrocarbon receptor nuclear translocator 2

decreases expression
multiple interactions

ISO

o,p'-DDT results in decreased expression of ARNT2 mRNA
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [o,p'-DDT results in decreased expression of ARNT2 mRNA]

NCBI chr 1:147,645,354...147,801,986
Ensembl chr 1:147,599,058...147,801,997

G

actin related protein 2/3 complex, subunit 1A

increases expression

ISO
EXP

o,p'-DDT results in increased expression of ARPC1A mRNA

NCBI chr12:9,502,496...9,525,304
Ensembl chr12:14,616,248...14,639,052

G

assembly factor for spindle microtubules

decreases expression

ISO

o,p'-DDT results in decreased expression of ASPM mRNA

NCBI chr13:53,625,584...53,674,489
Ensembl chr13:53,625,584...53,674,489

G

asparaginase and isoaspartyl peptidase 1

increases expression

ISO

o,p'-DDT results in increased expression of ASRGL1 mRNA

NCBI chr 1:215,436,180...215,456,188
Ensembl chr 1:215,435,218...215,456,198

G

ATPase family, AAA domain containing 3A

increases expression

ISO
EXP

o,p'-DDT results in increased expression of ATAD3A mRNA

NCBI chr 5:171,632,545...171,652,725
Ensembl chr 5:171,632,547...171,652,725

G

activating transcription factor 4

increases expression

EXP
ISO

o,p'-DDT results in increased expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions

ISO

[o,p'-DDT co-treated with DDT] results in increased expression of ATP1A1 mRNA

NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425

G

ATP synthase F1 subunit beta

increases expression

EXP
ISO

o,p'-DDT results in increased expression of ATP5F1B mRNA

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462

G

apoptosis and caspase activation inhibitor

increases expression

EXP
ISO

o,p'-DDT analog results in increased expression of AVEN mRNA; o,p'-DDT results in increased expression of AVEN mRNA

PMID:22937105 PMID:24096037

NCBI chr 3:119,753,395...119,886,009
Ensembl chr 3:119,872,661...119,886,008

G

BCL2-associated agonist of cell death

decreases expression

EXP

o,p'-DDT analog results in decreased expression of BAD mRNA; o,p'-DDT results in decreased expression of BAD mRNA

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BAG cochaperone 1

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of BAG1 mRNA
o,p'-DDT results in increased expression of BAG1 mRNA

NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:60,864,476...60,878,161

G

BCL2 associated X, apoptosis regulator

increases expression
decreases expression

EXP
ISO

o,p'-DDT results in increased expression of BAX mRNA
o,p'-DDT analog results in decreased expression of BAX mRNA
o,p'-DDT results in increased expression of BAX protein

PMID:22937105 PMID:35122929

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL10, immune signaling adaptor

decreases expression

EXP

o,p'-DDT results in decreased expression of BCL10 mRNA

NCBI chr 2:237,501,181...237,510,821
Ensembl chr 2:237,501,134...237,511,829

G

BCL2, apoptosis regulator

increases expression
multiple interactions
decreases expression

ISO
EXP

o,p'-DDT results in increased expression of BCL2 mRNA; o,p'-DDT results in increased expression of BCL2 protein
fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of BCL2 protein]
o,p'-DDT results in decreased expression of BCL2 protein

PMID:10545406 PMID:22609851 PMID:22937105 PMID:35122929

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL2-related protein A1

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of BCL2A1 mRNA
o,p'-DDT analog results in decreased expression of BCL2A1 mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

Bcl2-like 1

decreases expression

EXP

o,p'-DDT analog results in decreased expression of BCL2L1 mRNA

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

increases expression
decreases expression

EXP

o,p'-DDT analog results in increased expression of BCL2L11 mRNA; o,p'-DDT results in increased expression of BCL2L11 mRNA
o,p'-DDT analog results in decreased expression of BCL2L11 mRNA

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

Bcl2-like 2

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of BCL2L2 mRNA
o,p'-DDT analog results in decreased expression of BCL2L2 mRNA

NCBI chr15:32,326,686...32,337,834
Ensembl chr15:32,326,020...32,335,379

G

BCL2-associated transcription factor 1

decreases expression

EXP

o,p'-DDT analog results in decreased expression of BCLAF1 mRNA

NCBI chr 1:16,904,572...16,937,106
Ensembl chr 1:16,914,118...16,936,801

G

brain expressed X-linked 1

increases expression

ISO

o,p'-DDT results in increased expression of BEX2 mRNA

NCBI chr X:99,219,014...99,220,518
Ensembl chr X:104,010,371...104,011,236

G

BH3 interacting domain death agonist

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of BID mRNA
o,p'-DDT results in increased expression of BID mRNA

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

BCL2-interacting killer

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of BIK mRNA
o,p'-DDT analog results in decreased expression of BIK mRNA

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:116,552,303...116,571,317

G

baculoviral IAP repeat-containing 3

increases expression

EXP

o,p'-DDT analog results in increased expression of BIRC3 mRNA

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

baculoviral IAP repeat-containing 5

decreases expression

EXP

o,p'-DDT analog results in decreased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

BCL2 interacting protein 1

increases expression
decreases expression

ISO
EXP

o,p'-DDT results in increased expression of BNIP1 mRNA
o,p'-DDT analog results in decreased expression of BNIP1 mRNA

PMID:19371625 PMID:22937105

NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,891,317...16,903,561

G

BCL2 interacting protein 2

decreases expression

EXP

o,p'-DDT analog results in decreased expression of BNIP2 mRNA

NCBI chr 8:70,640,436...70,661,782
Ensembl chr 8:79,521,363...79,547,368

G

BCL2 interacting protein 3

increases expression

EXP

o,p'-DDT analog results in increased expression of BNIP3 mRNA; o,p'-DDT results in increased expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

BCL2 family apoptosis regulator BOK

decreases expression

EXP

o,p'-DDT analog results in decreased expression of BOK mRNA

NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:101,670,625...101,681,833

G

BRCA1, DNA repair associated

multiple interactions
increases expression

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of BRCA1 mRNA]; fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of BRCA1 mRNA]

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

complement C3

increases expression

ISO
EXP

o,p'-DDT results in increased expression of C3 mRNA; o,p'-DDT results in increased expression of C3 protein

PMID:10822019 PMID:11086226 PMID:11390168 PMID:24096037

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339

G

carbonic anhydrase 3

affects expression

EXP

o,p'-DDT affects the expression of CA3 mRNA

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

Cdk5 and Abl enzyme substrate 1

increases expression

ISO

o,p'-DDT results in increased expression of CABLES1 mRNA

NCBI chr18:3,076,556...3,181,181
Ensembl chr18:3,351,652...3,455,956

G

capping actin protein, gelsolin like

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CAPG mRNA

NCBI chr 4:106,152,912...106,170,010
Ensembl chr 4:106,152,890...106,170,672

G

calpain 9

increases expression

ISO

o,p'-DDT results in increased expression of CAPN9 mRNA

NCBI chr19:69,446,847...69,483,810
Ensembl chr19:69,446,847...69,483,810

G

carbonic anhydrase 2

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CAR2 mRNA

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

caspase recruitment domain family, member 10

decreases expression

EXP

o,p'-DDT analog results in decreased expression of CARD10 mRNA

NCBI chr 7:112,210,944...112,252,044
Ensembl chr 7:112,210,776...112,239,806

G

caspase recruitment domain family, member 6

decreases expression

EXP

o,p'-DDT analog results in decreased expression of CARD6 mRNA

NCBI chr 2:54,194,343...54,206,902
Ensembl chr 2:55,921,832...55,934,363

G

cysteinyl-tRNA synthetase 1

increases expression

ISO

o,p'-DDT results in increased expression of CARS1 mRNA

NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407

G

caspase 1

increases expression

EXP

o,p'-DDT analog results in increased expression of CASP1 mRNA

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 12

increases expression

EXP

o,p'-DDT results in increased expression of CASP12 mRNA

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:10,926,994...10,954,442

G

caspase 14

decreases expression

EXP

o,p'-DDT analog results in decreased expression of CASP14 mRNA

NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:11,580,339...11,583,171

G

caspase 2

increases expression

EXP

o,p'-DDT analog results in increased expression of CASP2 mRNA; o,p'-DDT results in increased expression of CASP2 mRNA

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

increases expression
multiple interactions

EXP
ISO

o,p'-DDT analog results in increased expression of CASP3 protein; o,p'-DDT results in increased expression of CASP3 mRNA; o,p'-DDT results in increased expression of CASP3 protein
o,p'-DDT results in increased expression of CASP3 protein modified form
Quercetin inhibits the reaction [o,p'-DDT results in increased expression of CASP3 protein modified form]

PMID:22937105 PMID:35122929

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 4

increases expression

EXP

o,p'-DDT results in increased expression of CASP4 mRNA

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:10,883,769...10,920,727

G

caspase 6

decreases expression

EXP

o,p'-DDT analog results in decreased expression of CASP6 mRNA

NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726

G

caspase 7

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of CASP7 mRNA
o,p'-DDT results in increased expression of CASP7 mRNA

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of CASP8 mRNA
o,p'-DDT results in increased expression of CASP8 mRNA

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 8 associated protein 2

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of CASP8AP2 mRNA; o,p'-DDT results in decreased expression of CASP8AP2 mRNA
o,p'-DDT analog results in increased expression of CASP8AP2 mRNA

NCBI chr 5:51,809,366...51,848,633
Ensembl chr 5:51,810,972...51,848,632

G

caspase 9

decreases expression
increases expression
affects expression
multiple interactions

EXP
ISO

o,p'-DDT analog results in decreased expression of CASP9 mRNA
o,p'-DDT results in increased expression of CASP9 mRNA
o,p'-DDT affects the expression of CASP9 mRNA
Quercetin inhibits the reaction [o,p'-DDT results in increased expression of CASP9 protein modified form]

PMID:18925944 PMID:22937105 PMID:35122929

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases activity

ISO

Quercetin inhibits the reaction [o,p'-DDT results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

coiled-coil domain containing 85A

increases methylation

ISO

o,p'-DDT results in increased methylation of CCDC85A gene

NCBI chr14:102,126,574...102,359,207
Ensembl chr14:106,327,580...106,560,165

G

C-C motif chemokine ligand 2

decreases expression

ISO

o,p'-DDT results in decreased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin A1

increases expression

ISO

o,p'-DDT results in increased expression of CCNA1 mRNA

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cyclin B1

affects expression

EXP

o,p'-DDT affects the expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin B2

affects expression

ISO
EXP

o,p'-DDT affects the expression of CCNB2 mRNA

PMID:17984292 PMID:18925944

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682

G

cyclin D1

multiple interactions
increases expression
affects expression

ISO
EXP

fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of CCND1 mRNA]
o,p'-DDT affects the expression of CCND1 mRNA

PMID:17984292 PMID:18925944 PMID:20206645 PMID:33728745

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D2

decreases expression

EXP
ISO

o,p'-DDT results in decreased expression of CCND2 mRNA

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

cyclin E2

decreases expression

ISO

o,p'-DDT results in decreased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

cyclin G2

affects expression

ISO

o,p'-DDT affects the expression of CCNG2 mRNA

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:15,088,695...15,096,206

G

chaperonin containing TCP1 subunit 2

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CCT2 mRNA

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:54,578,663...54,592,977

G

chaperonin containing TCP1 subunit 4

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CCT4 mRNA

NCBI chr14:96,991,853...97,004,732
Ensembl chr14:101,192,772...101,205,770

G

chaperonin containing TCP1 subunit 5

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CCT5 mRNA

NCBI chr 2:84,302,621...84,313,773
Ensembl chr 2:84,302,623...84,313,779

G

chaperonin containing TCP1 subunit 7

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CCT7 mRNA

NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:119,546,730...119,563,973

G

CD24 molecule

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CD24A mRNA

NCBI chr20:48,655,549...48,661,786
Ensembl chr20:48,655,805...48,661,785

G

CD34 molecule

decreases expression

ISO

o,p'-DDT results in decreased expression of CD34 mRNA

NCBI chr13:109,008,786...109,029,317
Ensembl chr13:109,008,623...109,029,315

G

CD40 molecule

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of CD40 mRNA
o,p'-DDT results in increased expression of CD40 mRNA

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

CD40 ligand

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of CD40LG mRNA
o,p'-DDT results in increased expression of CD40LG mRNA

NCBI chr X:140,164,341...140,176,057
Ensembl chr X:140,164,302...140,176,475

G

CD55 molecule (Cromer blood group)

increases expression

ISO

o,p'-DDT results in increased expression of CD55 mRNA

NCBI chr13:44,409,574...44,438,913
Ensembl chr13:44,409,587...44,438,107

G

cell division cycle 25A

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CDC25A mRNA

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188

G

cell division cycle associated 8

decreases expression

ISO

o,p'-DDT results in decreased expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:142,461,084...142,483,283

G

CUB domain containing protein 1

increases expression

ISO

o,p'-DDT results in increased expression of CDCP1 mRNA

NCBI chr 8:122,828,685...122,865,345
Ensembl chr 8:131,706,140...131,742,877

G

cadherin 1

decreases expression

ISO

o,p'-DDT results in decreased expression of CDH1 mRNA

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cyclin-dependent kinase 1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase 9

increases expression

EXP
ISO

o,p'-DDT results in increased expression of CDK9 mRNA

NCBI chr 3:36,394,168...36,399,016
Ensembl chr 3:36,394,169...36,399,528

G

cyclin-dependent kinase inhibitor 1A

affects expression
decreases expression

ISO
EXP

o,p'-DDT affects the expression of CDKN1A mRNA
o,p'-DDT results in decreased expression of CDKN1A mRNA

PMID:18925944 PMID:23209616

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

carboxylesterase 2A

affects expression

EXP

o,p'-DDT affects the expression of CES2A mRNA

NCBI chr19:129,428...136,480
Ensembl chr19:135,885...142,935

G

carboxylesterase 2H

affects expression

ISO

o,p'-DDT affects the expression of CES2 mRNA

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752

G

complement factor B

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CFB mRNA

NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740

G

CASP8 and FADD-like apoptosis regulator

decreases expression

EXP

o,p'-DDT analog results in decreased expression of CFLAR mRNA

NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434

G

ChaC glutathione specific gamma-glutamylcyclotransferase 2

increases expression

ISO

o,p'-DDT results in increased expression of CHAC2 mRNA

NCBI chr14:104,720,754...104,728,305
Ensembl chr14:108,921,341...108,929,469

G

cholinergic receptor, muscarinic 1

increases expression

ISO

o,p'-DDT results in increased expression of CHRM1 mRNA; o,p'-DDT results in increased expression of CHRM1 protein

NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602

G

cholinergic receptor, muscarinic 3

increases expression

ISO

o,p'-DDT results in increased expression of CHRM3 mRNA; o,p'-DDT results in increased expression of CHRM3 protein

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304

G

cholinergic receptor nicotinic alpha 1 subunit

increases expression

ISO

o,p'-DDT results in increased expression of CHRNA1 mRNA; o,p'-DDT results in increased expression of CHRNA1 protein

NCBI chr 3:78,862,286...78,877,353
Ensembl chr 3:78,862,286...78,877,353

G

cytokine induced apoptosis inhibitor 1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CIAPIN1 mRNA

NCBI chr19:10,185,955...10,199,120
Ensembl chr19:10,182,088...10,201,495

G

cell death-inducing DFFA-like effector a

decreases expression

EXP

o,p'-DDT analog results in decreased expression of CIDEA mRNA

NCBI chr18:63,164,817...63,190,384
Ensembl chr18:63,164,099...63,190,382

G

cell death-inducing DFFA-like effector b

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of CIDEB mRNA
o,p'-DDT results in increased expression of CIDEB mRNA

NCBI chr15:33,222,135...33,226,407
Ensembl chr15:33,221,824...33,226,688

G

cold inducible RNA binding protein

decreases expression

ISO

o,p'-DDT results in decreased expression of CIRBP mRNA

NCBI chr 7:9,533,857...9,538,899

G

clusterin

decreases expression

EXP

o,p'-DDT results in decreased expression of CLU mRNA

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

cytochrome c oxidase subunit 5A

increases expression

EXP
ISO

o,p'-DDT results in increased expression of COX5A mRNA

NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:66,818,196...66,830,279

G

cytochrome c oxidase subunit 6B1

increases expression

ISO

o,p'-DDT results in increased expression of COX6B1 mRNA

NCBI chr 1:95,002,513...95,011,516
Ensembl chr 1:95,001,707...95,011,431
Ensembl chr 5:95,001,707...95,011,431

G

copine 7

increases expression

ISO

o,p'-DDT results in increased expression of CPNE7 mRNA

NCBI chr19:51,164,316...51,182,676
Ensembl chr19:68,074,545...68,091,197

G

carboxypeptidase X (M14 family), member 1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CPXM1 mRNA

NCBI chr 3:117,588,532...117,595,330
Ensembl chr 3:138,041,645...138,048,857

G

CASP2 and RIPK1 domain containing adaptor with death domain

decreases expression

EXP

o,p'-DDT analog results in decreased expression of CRADD mRNA

NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:31,685,622...31,874,512

G

cAMP responsive element binding protein 1

increases phosphorylation
increases activity
affects localization

ISO

o,p'-DDT results in increased phosphorylation of CREB1 protein
o,p'-DDT results in increased activity of CREB1 protein
o,p'-DDT affects the localization of CREB1 protein

PMID:18791200 PMID:20678559

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

CREB binding protein

multiple interactions
increases activity

ISO

o,p'-DDT promotes the reaction [MAP2K6 protein results in increased activity of CREBBP protein]; SB 203580 inhibits the reaction [o,p'-DDT results in increased activity of CREBBP protein]

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

crooked neck pre-mRNA splicing factor 1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CRNKL1 mRNA

NCBI chr 3:153,764,718...153,807,973
Ensembl chr 6:6,894,292...6,896,635
Ensembl chr 3:6,894,292...6,896,635

G

casein kinase 2 alpha 1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of CSNK2A1 mRNA

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698

G

catenin beta 1

decreases expression

ISO

o,p'-DDT results in decreased expression of CTNNB1 mRNA

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin D

increases expression

ISO

o,p'-DDT results in increased expression of CTSD mRNA

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

C-X3-C motif chemokine ligand 1

decreases expression

ISO

o,p'-DDT results in decreased expression of CX3CL1 mRNA

NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999

G

cytochrome b-245 alpha chain

increases expression
multiple interactions

ISO
EXP

o,p'-DDT results in increased expression of CYBA mRNA
Quercetin inhibits the reaction [o,p'-DDT results in increased expression of CYBA mRNA]

PMID:24096037 PMID:35122929

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214

G

cytochrome b-245 beta chain

increases expression
multiple interactions

ISO

o,p'-DDT results in increased expression of CYBB mRNA
Quercetin inhibits the reaction [o,p'-DDT results in increased expression of CYBB mRNA]

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

cytochrome c, somatic

increases expression
multiple interactions

ISO
EXP

o,p'-DDT results in increased expression of CYCS mRNA
o,p'-DDT results in increased expression of CYCS protein
Quercetin inhibits the reaction [o,p'-DDT results in increased expression of CYCS protein]

PMID:24096037 PMID:35122929

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression

EXP

o,p'-DDT results in decreased expression of CYP11A1 mRNA

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

cytochrome P450, family 17, subfamily a, polypeptide 1

affects expression

EXP
ISO

o,p'-DDT affects the expression of CYP17A1 mRNA

PMID:17984292 PMID:18925944

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
increases expression
decreases activity
decreases expression

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 mRNA]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; [alpha-naphthoflavone results in decreased activity of CYP19A1 protein] which results in decreased susceptibility to o,p'-DDT; [Dichlorodiphenyl Dichloroethylene co-treated with o,p'-DDT] results in decreased activity of CYP19A1 protein; [o,p'-DDT co-treated with Atrazine] results in increased activity of CYP19A1 protein; [vinclozolin co-treated with o,p'-DDT] results in decreased activity of CYP19A1 protein; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 mRNA]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]
o,p'-DDT results in increased expression of CYP19A1 mRNA; o,p'-DDT results in increased expression of CYP19A1 protein
o,p'-DDT results in decreased activity of CYP19A1 protein
o,p'-DDT results in decreased expression of CYP19A1 mRNA

PMID:17599374 PMID:20678559 PMID:28263910

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

affects expression
multiple interactions
increases expression

ISO

o,p'-DDT affects the expression of CYP1A1 mRNA
o,p'-DDT inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; o,p'-DDT inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; o,p'-DDT promotes the reaction [AHR protein binds to CYP1A1 promoter]
o,p'-DDT results in increased expression of CYP1A1 mRNA

PMID:12176094 PMID:18925944 PMID:28263910

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects expression
increases expression

ISO

o,p'-DDT affects the expression of CYP1A2 mRNA
o,p'-DDT results in increased expression of CYP1A2 mRNA

PMID:18925944 PMID:21924250

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 2

affects expression

ISO
EXP

o,p'-DDT affects the expression of CYP2B13 mRNA
o,p'-DDT affects the expression of CYP2B2 mRNA

PMID:17984292 PMID:18925944

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions
affects expression

ISO

o,p'-DDT results in increased expression of CYP2B6 mRNA; o,p'-DDT results in increased expression of CYP2B6 protein
o,p'-DDT inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]
o,p'-DDT affects the expression of CYP2B10 mRNA

PMID:10037683 PMID:15548381 PMID:18925944 PMID:21924250

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily c, polypeptide 23

affects expression

EXP

o,p'-DDT affects the expression of CYP2C23 mRNA

NCBI chr 1:242,889,218...242,913,869
Ensembl chr 1:252,838,433...252,863,067

G

cytochrome P450, family 2, subfamily c, polypeptide 24

affects expression

ISO

o,p'-DDT affects the expression of CYP2C55 mRNA

NCBI chr 1:246,286,341...246,348,607
Ensembl chr 1:246,286,341...246,348,607

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects expression
increases expression
multiple interactions
increases activity

EXP
ISO

o,p'-DDT affects the expression of CYP3A2 mRNA
o,p'-DDT results in increased expression of CYP3A4 mRNA; o,p'-DDT results in increased expression of CYP3A4 protein
Dactinomycin inhibits the reaction [o,p'-DDT results in increased expression of CYP3A4 mRNA]
o,p'-DDT results in increased activity of CYP3A4 protein

PMID:15548381 PMID:15795092 PMID:17035600 PMID:17984292 PMID:21924250

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

affects expression

EXP

o,p'-DDT affects the expression of CYP3A23-3A1 mRNA

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 51

affects expression

ISO

o,p'-DDT affects the expression of CYP51 mRNA

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

cytochrome P450 family 7 subfamily A member 1

affects expression

ISO

o,p'-DDT affects the expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytochrome P450 family 7 subfamily B member 1

affects expression

ISO

o,p'-DDT affects the expression of CYP7B1 mRNA

NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:102,419,011...102,451,804

G

death associated protein kinase 1

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of DAPK1 mRNA
o,p'-DDT results in increased expression of DAPK1 mRNA

NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,935,625...4,096,581

G

decorin

decreases expression

ISO
EXP

o,p'-DDT results in decreased expression of DCN mRNA

NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926

G

DExD-box helicase 39A

increases expression

EXP
ISO

o,p'-DDT results in increased expression of DDX39A mRNA

NCBI chr19:41,323,465...41,331,413
Ensembl chr19:41,322,836...41,332,306

G

desmin

increases expression

EXP
ISO

o,p'-DDT results in increased expression of DES mRNA

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347

G

DNA fragmentation factor subunit alpha

increases expression

EXP

o,p'-DDT analog results in increased expression of DFFA mRNA; o,p'-DDT results in increased expression of DFFA mRNA

NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:164,823,807...164,836,728

G

DNA fragmentation factor subunit beta

decreases expression

EXP

o,p'-DDT analog results in decreased expression of DFFB mRNA

NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:169,804,889...169,817,225

G

7-dehydrocholesterol reductase

affects expression

EXP

o,p'-DDT affects the expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382

G

dehydrogenase/reductase 3

increases expression

ISO

o,p'-DDT results in increased expression of DHRS3 mRNA

NCBI chr 5:162,031,853...162,065,655
Ensembl chr 5:162,031,386...162,065,653

G

DnaJ heat shock protein family (Hsp40) member C2

affects expression

EXP

o,p'-DDT affects the expression of DNAJC2 mRNA

NCBI chr 4:13,270,239...13,297,438
Ensembl chr 4:14,163,838...14,192,846

G

delta/notch-like EGF repeat containing

increases expression

ISO

o,p'-DDT results in increased expression of DNER mRNA

NCBI chr 9:93,035,108...93,350,568
Ensembl chr 9:93,035,108...93,350,568

G

DNA methyltransferase 3 alpha

increases expression

EXP
ISO

o,p'-DDT results in increased expression of DNMT3A mRNA

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970

G

double C2-like domains, gamma

affects expression

EXP

o,p'-DDT affects the expression of DOC2G mRNA

NCBI chr 1:201,295,377...201,299,867
Ensembl chr 1:210,725,748...210,730,048

G

destrin, actin depolymerizing factor

increases expression

EXP
ISO

o,p'-DDT results in increased expression of DSTN mRNA

NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:151,737,849...151,764,769

G

dynein light chain LC8-type 1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of DYNLL1 mRNA

NCBI chr12:46,945,291...46,976,867
Ensembl chr12:46,973,050...46,976,861

G

E2F transcription factor 7

increases expression

ISO

o,p'-DDT results in increased expression of E2F7 mRNA

NCBI chr 7:48,036,881...48,079,055
Ensembl chr 7:48,037,749...48,079,055

G

eukaryotic translation elongation factor 1 gamma

increases expression

ISO
EXP

o,p'-DDT results in increased expression of EEF1G mRNA

NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:215,277,860...215,301,479

G

eukaryotic translation initiation factor 2B subunit delta

increases expression

ISO

o,p'-DDT results in increased expression of EIF2B4 mRNA

NCBI chr 6:30,903,148...30,908,803
Ensembl chr 6:30,903,219...30,908,800

G

eukaryotic translation initiation factor 2 subunit beta

affects expression
increases expression

EXP
ISO

o,p'-DDT affects the expression of EIF2S2 mRNA
o,p'-DDT results in increased expression of EIF2S2 mRNA

PMID:17984292 PMID:24096037

NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:163,834,851...163,855,570

G

eukaryotic translation initiation factor 3, subunit C

affects expression

EXP

o,p'-DDT affects the expression of EIF3C mRNA

NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:190,565,184...190,583,067

G

eukaryotic translation initiation factor 3, subunit G

increases expression

ISO
EXP

o,p'-DDT results in increased expression of EIF3G mRNA

NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:27,705,915...27,709,987

G

eukaryotic translation initiation factor 4E binding protein 1

affects expression

EXP

o,p'-DDT affects the expression of EIF4EBP1 mRNA

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

eukaryotic translation initiation factor 5

increases expression

ISO
EXP

o,p'-DDT results in increased expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:136,407,440...136,418,821

G

ETS transcription factor ELK1

increases activity

ISO

o,p'-DDT results in increased activity of ELK1 protein

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:3,693,293...3,709,249

G

elongin B

increases expression

ISO
EXP

o,p'-DDT results in increased expression of ELOB mRNA

NCBI chr10:12,848,830...12,853,897
Ensembl chr10:13,353,417...13,358,563

G

epoxide hydrolase 1

affects expression

EXP

o,p'-DDT affects the expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981

G

glutamyl-prolyl-tRNA synthetase 1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of EPRS1 mRNA

NCBI chr13:99,431,955...99,503,510
Ensembl chr13:99,433,130...99,503,509

G

erb-b2 receptor tyrosine kinase 2

increases activity

ISO

o,p'-DDT results in increased activity of ERBB2 protein

PMID:9443065 PMID:11222871

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481

G

ERCC excision repair 3, TFIIH core complex helicase subunit

increases expression

ISO

o,p'-DDT results in increased expression of ERCC3 mRNA

NCBI chr18:24,157,831...24,188,543
Ensembl chr18:24,148,084...24,190,898

G

epiregulin

decreases expression

EXP

o,p'-DDT results in decreased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260

G

estrogen receptor 1

affects binding
decreases expression
increases expression
multiple interactions
increases activity

ISO
EXP

o,p'-DDT binds to ESR1 protein
o,p'-DDT results in decreased expression of ESR1 mRNA; o,p'-DDT results in decreased expression of ESR1 protein
o,p'-DDT results in increased expression of ESR1 mRNA
[o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR1 protein; o,p'-DDT inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
o,p'-DDT results in increased activity of ESR1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in decreased expression of ESR1 mRNA]; [Estradiol co-treated with Genistein co-treated with o,p'-DDT] affects the expression of ESR1 mRNA; [o,p'-DDT co-treated with Methoxychlor co-treated with Dieldrin] results in increased expression of ESR1 mRNA; Fulvestrant inhibits the reaction [o,p'-DDT results in decreased expression of ESR1 mRNA]; o,p'-DDT binds to and results in increased activity of ESR1 protein; o,p'-DDT inhibits the reaction [Estradiol binds to ESR1 protein]; o,p'-DDT promotes the reaction [Estradiol results in increased activity of ESR1 protein]

PMID:8930550 PMID:9751507 PMID:9860891 PMID:11086226 PMID:11162928 More...

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions
decreases expression
increases activity

ISO
EXP

o,p'-DDT binds to and results in increased activity of ESR2 protein
o,p'-DDT results in decreased expression of ESR2 mRNA
[o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR2 protein
o,p'-DDT results in increased activity of ESR2 protein
o,p'-DDT results in decreased expression of ESR2 mRNA; o,p'-DDT results in decreased expression of ESR2 protein

PMID:9751507 PMID:9860891 PMID:15064155 PMID:16626760 PMID:18700809 More...

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

ethanolamine kinase 2

increases expression

ISO

o,p'-DDT results in increased expression of ETNK2 mRNA

NCBI chr13:47,362,964...47,381,100
Ensembl chr13:47,363,060...47,381,100

G

Fas associated via death domain

decreases expression

EXP

o,p'-DDT analog results in decreased expression of FADD mRNA

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

fatty acid desaturase 2

decreases expression

ISO

o,p'-DDT results in decreased expression of FADS2 mRNA

NCBI chr 1:216,132,277...216,172,190
Ensembl chr 1:216,133,676...216,172,066

G

Fas apoptotic inhibitory molecule

decreases expression

EXP

o,p'-DDT analog results in decreased expression of FAIM mRNA; o,p'-DDT results in decreased expression of FAIM mRNA

NCBI chr 8:108,423,259...108,445,365
Ensembl chr 8:108,423,221...108,440,151

G

family with sequence similarity 107, member A

decreases expression

ISO

o,p'-DDT results in decreased expression of FAM107A mRNA

NCBI chr15:19,038,726...19,060,644
Ensembl chr15:19,038,616...19,065,219

G

Fas cell surface death receptor

affects expression
decreases expression
increases expression

ISO
EXP

o,p'-DDT affects the expression of FAS mRNA
o,p'-DDT analog results in decreased expression of FAS mRNA
o,p'-DDT results in increased expression of FAS mRNA

PMID:18925944 PMID:22937105

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

increases expression
decreases expression

ISO
EXP

o,p'-DDT results in increased expression of FASLG mRNA
o,p'-DDT analog results in decreased expression of FASLG mRNA

PMID:22609851 PMID:22937105

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fibrillin 2

increases expression

ISO

o,p'-DDT results in increased expression of FBN2 mRNA

NCBI chr18:53,696,197...53,901,992
Ensembl chr18:53,697,708...53,902,191

G

folate receptor alpha

decreases expression

ISO

o,p'-DDT results in decreased expression of FOLR1 mRNA

NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:165,631,462...165,642,669

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions
affects localization

ISO
EXP

o,p'-DDT results in increased expression of FOS mRNA
o,p'-DDT results in increased expression of and results in increased activity of FOS protein
o,p'-DDT affects the localization of FOS protein

PMID:18840457 PMID:24096037 PMID:34167450

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FOS like 1, AP-1 transcription factor subunit

increases expression

ISO

o,p'-DDT results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

forkhead box D1

increases expression

ISO

o,p'-DDT results in increased expression of FOXD1 mRNA

NCBI chr 2:29,702,558...29,704,978
Ensembl chr 2:31,436,813...31,439,399

G

follicle stimulating hormone subunit beta

multiple interactions

ISO

o,p'-DDT promotes the reaction [[FSHB protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

follicle stimulating hormone receptor

multiple interactions

ISO

o,p'-DDT promotes the reaction [[FSHB protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]

NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:10,952,329...11,160,288

G

ferritin light chain 1

affects expression

EXP

o,p'-DDT affects the expression of FTL1 mRNA

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

FXYD domain-containing ion transport regulator 4

decreases expression

EXP
ISO

o,p'-DDT results in decreased expression of FXYD4 mRNA

NCBI chr 4:151,109,779...151,113,659
Ensembl chr 4:152,782,181...152,786,039

G

G0/G1switch 2

increases expression

ISO
EXP

o,p'-DDT results in increased expression of G0S2 mRNA

PMID:19371625 PMID:24096037

NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293

G

growth arrest and DNA-damage-inducible, alpha

affects expression
increases expression

ISO
EXP

o,p'-DDT affects the expression of GADD45A mRNA
o,p'-DDT analog results in increased expression of GADD45A mRNA; o,p'-DDT results in increased expression of GADD45A mRNA

PMID:18925944 PMID:22937105

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

growth arrest and DNA-damage-inducible, beta

affects expression

ISO

o,p'-DDT affects the expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

polypeptide N-acetylgalactosaminyltransferase 4

increases expression

ISO

o,p'-DDT results in increased expression of GALNT4 mRNA

NCBI chr 7:33,925,229...33,927,770

G

galanin receptor 2

decreases expression

ISO

o,p'-DDT results in decreased expression of GALR2 mRNA

NCBI chr10:101,513,689...101,517,176
Ensembl chr10:102,013,370...102,016,055

G

glutamate-cysteine ligase, catalytic subunit

affects expression

EXP

o,p'-DDT affects the expression of GCLC mRNA

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

affects expression

EXP
ISO

o,p'-DDT affects the expression of GCLM mRNA

PMID:17984292 PMID:18925944

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glycerophosphodiester phosphodiesterase domain containing 5

increases expression

ISO

o,p'-DDT results in increased expression of GDPD5 mRNA

NCBI chr 1:163,091,844...163,173,559
Ensembl chr 1:163,091,833...163,173,559

G

gonadotropin releasing hormone 1

multiple interactions
affects secretion

EXP

o,p'-DDT affects the reaction [LHB protein results in increased susceptibility to GNRH1 protein]
o,p'-DDT affects the secretion of GNRH1 protein

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977

G

G protein-coupled receptor 142

increases expression

ISO

o,p'-DDT results in increased expression of GPR142 mRNA

NCBI chr10:99,840,069...99,843,410
Ensembl chr10:100,339,112...100,342,453

G

glutathione peroxidase 2

affects expression

EXP

o,p'-DDT affects the expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

GRAM domain containing 2B

decreases expression

ISO

o,p'-DDT results in decreased expression of GRAMD2B mRNA

NCBI chr18:52,082,128...52,180,056
Ensembl chr18:52,082,029...52,180,054

G

gremlin 1, DAN family BMP antagonist

increases expression

ISO

o,p'-DDT results in increased expression of GREM1 mRNA

NCBI chr 3:120,966,639...120,978,319
Ensembl chr 3:120,966,623...120,979,089

G

G1 to S phase transition 1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of GSPT1 mRNA

NCBI chr10:4,362,528...4,397,215
Ensembl chr10:4,869,465...4,908,040

G

glutathione-disulfide reductase

affects expression

ISO

o,p'-DDT affects the expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 2

affects expression

ISO

o,p'-DDT affects the expression of GSTA2 mRNA

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092

G

glutathione S-transferase alpha 3

affects expression

EXP

o,p'-DDT affects the expression of GSTA3 mRNA

NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654

G

glutathione S-transferase alpha 5

affects expression

ISO

o,p'-DDT affects the expression of GSTA1 mRNA

NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765

G

glutathione S-transferase mu 2

affects expression

ISO

o,p'-DDT affects the expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase theta 1

affects expression

EXP

o,p'-DDT affects the expression of GSTT1 mRNA

NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019

G

granzyme A

increases expression

ISO
EXP

o,p'-DDT results in increased expression of GZMA mRNA

NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:46,473,763...46,485,696

G

hyaluronan and proteoglycan link protein 3

decreases expression

ISO

o,p'-DDT results in decreased expression of HAPLN3 mRNA

NCBI chr 1:142,455,828...142,473,877
Ensembl chr 1:142,454,629...142,471,832

G

hes family bHLH transcription factor 2

increases expression

ISO

o,p'-DDT results in increased expression of HES2 mRNA

NCBI chr 5:167,947,948...167,964,660
Ensembl chr 5:167,949,918...167,955,601

G

histone cluster 1 H2B family member D

decreases expression

ISO

o,p'-DDT results in decreased expression of H2BC5 mRNA

NCBI chr17:47,488,627...47,489,008

G

HIVEP zinc finger 1

increases expression

ISO

o,p'-DDT results in increased expression of HIVEP1 mRNA

NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,790,855...22,917,196

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

ISO

o,p'-DDT results in decreased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

high mobility group nucleosomal binding domain 2

decreases expression

ISO

o,p'-DDT results in decreased expression of HMGN2 mRNA

NCBI chr 5:151,475,907...151,479,361
Ensembl chr 5:151,475,909...151,479,397

G

heme oxygenase 1

affects expression

EXP

o,p'-DDT affects the expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heme oxygenase 2

affects expression

ISO

o,p'-DDT affects the expression of HMOX2 mRNA

NCBI chr10:10,797,076...10,831,178
Ensembl chr10:11,303,512...11,318,800

G

heterogeneous nuclear ribonucleoprotein A/B

increases expression

ISO
EXP

o,p'-DDT results in increased expression of HNRNPAB mRNA

NCBI chr10:35,857,040...35,862,935
Ensembl chr10:36,358,006...36,364,307

G

heterogeneous nuclear ribonucleoprotein U

increases expression

ISO
EXP

o,p'-DDT results in increased expression of HNRNPU mRNA

NCBI chr13:92,609,791...92,618,580
Ensembl chr13:92,605,216...92,618,612

G

harakiri, BCL2 interacting protein

decreases expression
increases expression

EXP
ISO

o,p'-DDT analog results in decreased expression of HRK mRNA
o,p'-DDT results in increased expression of HRK mRNA

PMID:18204070 PMID:22937105

NCBI chr12:38,387,484...38,409,652
Ensembl chr12:44,048,402...44,070,561

G

heat shock protein 90 alpha family class A member 1

increases expression
affects expression

ISO
EXP

o,p'-DDT results in increased expression of HSP90AA1 mRNA
o,p'-DDT affects the expression of HSP90AA1 mRNA

PMID:17984292 PMID:24096037

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein 90 alpha family class B member 1

affects expression

EXP

o,p'-DDT affects the expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 2

decreases expression

ISO

o,p'-DDT results in decreased expression of HSPA2 mRNA

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133

G

heat shock protein family A (Hsp70) member 4

increases expression

ISO
EXP

o,p'-DDT results in increased expression of HSPA4 mRNA
o,p'-DDT analog results in increased expression of HSPA4 mRNA; o,p'-DDT results in increased expression of HSPA4 mRNA

PMID:22937105 PMID:24096037

NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,908,866...37,949,835

G

heat shock protein family A (Hsp70) member 8

increases expression

ISO
EXP

o,p'-DDT results in increased expression of HSPA8 mRNA

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

heat shock protein family D (Hsp60) member 1

increases expression
affects expression

ISO
EXP

o,p'-DDT results in increased expression of HSPD1 mRNA
o,p'-DDT affects the expression of HSPD1 mRNA

PMID:17984292 PMID:24096037

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

heat shock protein family E (Hsp10) member 1

affects expression

EXP

o,p'-DDT affects the expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:64,085,068...64,087,502

G

heat shock protein family H (Hsp110) member 1

increases expression

EXP
ISO

o,p'-DDT results in increased expression of HSPH1 mRNA

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

ISO

o,p'-DDT results in decreased expression of IDI1 mRNA

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

insulin-like growth factor 1

affects expression
increases expression

EXP
ISO

o,p'-DDT affects the expression of IGF1 mRNA
o,p'-DDT results in increased expression of IGF1 mRNA

PMID:17984292 PMID:24096037

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor binding protein 3

affects expression

EXP

o,p'-DDT affects the expression of IGFBP3 mRNA

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944

G

interleukin 10

decreases expression

EXP

o,p'-DDT analog results in decreased expression of IL10 mRNA

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions
increases expression

ISO

[DDT co-treated with o,p'-DDT] results in decreased expression of IL1B mRNA
o,p'-DDT results in increased expression of IL1B

PMID:12007859 PMID:15104118

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 24

increases expression

ISO

o,p'-DDT results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 6

increases expression

ISO

o,p'-DDT results in increased expression of IL6; o,p'-DDT results in increased expression of IL6 mRNA

PMID:15104118 PMID:17035600

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

increases expression

ISO

o,p'-DDT results in increased expression of IL6R mRNA

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

inosine monophosphate dehydrogenase 2

increases expression

ISO

o,p'-DDT results in increased expression of IMPDH2 mRNA

NCBI chr 8:118,135,204...118,139,892
Ensembl chr 8:118,135,262...118,139,873

G

insulin induced gene 2

affects expression

ISO

o,p'-DDT affects the expression of INSIG2 mRNA

NCBI chr13:35,025,160...35,052,937
Ensembl chr13:35,025,164...35,047,658

G

interferon regulatory factor 1

affects expression

EXP

o,p'-DDT affects the expression of IRF1 mRNA

NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947

G

integrin subunit alpha 6

increases expression

ISO

o,p'-DDT results in increased expression of ITGA6 mRNA

NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions
affects localization

EXP
ISO

o,p'-DDT results in increased expression of JUN mRNA
o,p'-DDT results in increased expression of and results in increased activity of JUN protein
o,p'-DDT affects the localization of JUN protein

PMID:18840457 PMID:24096037 PMID:34167450

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

potassium voltage-gated channel subfamily A member 3

multiple interactions
decreases activity

ISO

[o,p'-DDT results in decreased activity of KCNA3 protein] which results in decreased import of Thallium

NCBI chr 2:197,320,324...197,322,277
Ensembl chr 2:197,318,134...197,350,739

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

ISO

[o,p'-DDT results in decreased activity of KCNH2 protein] which results in decreased import of Thallium

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium channel tetramerization domain containing 20

increases expression

ISO

o,p'-DDT results in increased expression of KCTD20 mRNA

NCBI chr20:7,017,480...7,034,440
Ensembl chr20:7,017,502...7,034,441

G

kinesin family member 20A

decreases expression

ISO

o,p'-DDT results in decreased expression of KIF20A mRNA

NCBI chr18:26,504,422...26,512,908
Ensembl chr18:26,504,072...26,512,909

G

KLF transcription factor 4

increases expression

ISO

o,p'-DDT results in increased expression of KLF4 mRNA

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592

G

keratin 13

increases expression

ISO
EXP

o,p'-DDT results in increased expression of KRT13 mRNA

NCBI chr10:85,552,287...85,556,499
Ensembl chr10:85,552,287...85,556,499

G

keratin 17

decreases expression

ISO

o,p'-DDT results in decreased expression of KRT17 mRNA

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,679,070...85,683,787

G

keratin 8

increases expression

ISO
EXP

o,p'-DDT results in increased expression of KRT8 mRNA

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

La ribonucleoprotein 6, translational regulator

increases expression

ISO

o,p'-DDT results in increased expression of LARP6 mRNA

NCBI chr 8:61,183,744...61,205,548
Ensembl chr 8:70,079,647...70,101,198

G

low density lipoprotein receptor

decreases expression

ISO

o,p'-DDT results in decreased expression of LDLR mRNA

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

luteinizing hormone subunit beta

multiple interactions

EXP

o,p'-DDT affects the reaction [LHB protein results in increased susceptibility to GNRH1 protein]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

LIM homeobox 4

decreases expression

EXP

o,p'-DDT analog results in decreased expression of LHX4 mRNA

NCBI chr13:70,423,768...70,477,337
Ensembl chr13:70,427,399...70,467,505

G

lipase G, endothelial type

decreases expression

ISO

o,p'-DDT results in decreased expression of LIPG mRNA

NCBI chr18:70,790,077...70,811,259
Ensembl chr18:70,790,077...70,812,260

G

lamin A/C

increases expression

ISO
EXP

o,p'-DDT results in increased expression of LMNA mRNA

NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:176,237,564...176,288,072

G

leucine rich repeat containing 17

decreases expression

ISO

o,p'-DDT results in decreased expression of LRRC17 mRNA

NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:14,393,640...14,424,048

G

lymphotoxin alpha

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of LTA mRNA
o,p'-DDT results in increased expression of LTA mRNA

NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533

G

lymphotoxin beta receptor

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of LTBR mRNA
o,p'-DDT analog results in decreased expression of LTBR mRNA

NCBI chr 4:159,795,115...159,801,571
Ensembl chr 4:159,795,115...159,807,296

G

lactotransferrin

multiple interactions
increases expression

ISO

fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of LTF mRNA]
o,p'-DDT results in increased expression of LTF mRNA; o,p'-DDT results in increased expression of LTF protein

PMID:9607801 PMID:11390168

NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:119,878,344...119,901,189

G

latexin

decreases expression

ISO

o,p'-DDT results in decreased expression of LXN mRNA

NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:154,037,292...154,043,488

G

LYL1, basic helix-loop-helix family member

increases expression

ISO
EXP

o,p'-DDT results in increased expression of LYL1 mRNA

NCBI chr19:40,356,967...40,359,834
Ensembl chr19:40,354,819...40,359,834

G

lysosomal trafficking regulator

increases expression

ISO

o,p'-DDT results in increased expression of LYST mRNA

NCBI chr17:86,241,384...86,443,501
Ensembl chr17:93,225,540...93,427,650

G

MAF bZIP transcription factor B

increases expression

ISO
EXP

o,p'-DDT results in increased expression of MAFB mRNA

NCBI chr 3:169,417,890...169,419,810
Ensembl chr 3:169,416,945...169,419,975

G

MAGE family member D1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of MAGED1 mRNA

NCBI chr X:63,416,464...63,423,167
Ensembl chr X:63,416,466...63,423,112

G

MAK16 homolog

increases expression

ISO

o,p'-DDT results in increased expression of RBM13 mRNA

NCBI chr16:60,972,699...60,981,250
Ensembl chr16:67,675,735...67,684,836

G

MANSC domain containing 1

decreases expression

ISO

o,p'-DDT results in decreased expression of MANSC1 mRNA

NCBI chr 4:167,438,817...167,459,047
Ensembl chr 4:169,170,164...169,189,864

G

mitogen-activated protein kinase kinase 6

multiple interactions

ISO

o,p'-DDT promotes the reaction [MAP2K6 protein results in increased activity of CREBBP protein]

NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions
increases activity

ISO
EXP

o,p'-DDT results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK1 protein]; MAPK1 protein promotes the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK1 protein]; o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK1 protein
o,p'-DDT results in increased activity of MAPK1 protein

PMID:11222871 PMID:12523960 PMID:18791200 PMID:18840457 PMID:20678559 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 13

decreases expression

ISO

o,p'-DDT results in decreased expression of MAPK13 mRNA

NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,837,013...6,847,191

G

mitogen activated protein kinase 14

multiple interactions

ISO

MAPK14 protein promotes the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK3 protein]; o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK3 protein]

PMID:11222871 PMID:18840457 PMID:20678559 PMID:34167450

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

ISO

o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK8 protein; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK8 protein]
o,p'-DDT results in increased phosphorylation of MAPK8 protein
pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK8 protein]

PMID:18840457 PMID:20678559

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 8 interacting protein 1

increases expression

EXP

o,p'-DDT analog results in increased expression of MAPK8IP1 mRNA; o,p'-DDT results in increased expression of MAPK8IP1 mRNA

NCBI chr 3:98,810,540...98,829,302
Ensembl chr 3:98,810,541...98,828,368

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

ISO

pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK9 protein]
o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK9 protein; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK9 protein]

PMID:18840457 PMID:20678559

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

MCL1 apoptosis regulator, BCL2 family member

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of MCL1 mRNA
o,p'-DDT analog results in decreased expression of MCL1 mRNA

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

MDM2 proto-oncogene

affects expression

ISO

o,p'-DDT affects the expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

mesenchyme homeobox 1

decreases expression

ISO

o,p'-DDT results in decreased expression of MEOX1 mRNA

NCBI chr10:87,318,668...87,338,169
Ensembl chr10:87,318,695...87,337,976

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

ISO

o,p'-DDT results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

milk fat globule EGF and factor V/VIII domain containing

decreases expression

ISO

o,p'-DDT results in decreased expression of MFGE8 mRNA

NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:142,474,028...142,489,431

G

mitofusin 2

increases expression

ISO

o,p'-DDT results in increased expression of MFN2 mRNA

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

melanophilin

increases expression

ISO

o,p'-DDT results in increased expression of MLPH mRNA

NCBI chr 9:98,955,036...98,990,566
Ensembl chr 9:98,955,141...98,990,556

G

matrix metallopeptidase 2

increases expression

ISO

o,p'-DDT results in increased expression of MMP2 mRNA

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 23

increases expression

ISO
EXP

o,p'-DDT results in increased expression of MMP23 mRNA

NCBI chr 5:166,239,643...166,242,734
Ensembl chr 5:171,520,494...171,524,695

G

matrix metallopeptidase 9

increases expression

ISO

o,p'-DDT results in increased expression of MMP9 mRNA

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

mitochondrial ribosomal protein S7

increases expression

ISO

o,p'-DDT results in increased expression of MRPS7 mRNA

NCBI chr10:101,342,642...101,345,790
Ensembl chr10:101,342,421...101,346,082

G

mucin 5AC, oligomeric mucus/gel-forming

increases expression
multiple interactions

ISO

o,p'-DDT results in increased expression of MUC5AC mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]; Curcumin inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]; SB 203580 inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006

G

myc target 1

increases expression

ISO

o,p'-DDT results in increased expression of MYCT1 mRNA

NCBI chr 1:42,018,137...42,029,410
Ensembl chr 1:44,423,544...44,436,992

G

myosin heavy chain 6

increases expression

ISO
EXP

o,p'-DDT results in increased expression of MYH6 mRNA

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333

G

myosin VA

increases expression

ISO
EXP

o,p'-DDT results in increased expression of MYO5A mRNA

NCBI chr 8:84,692,524...84,860,564
Ensembl chr 8:84,692,910...84,856,265

G

myosin Vb

increases expression

ISO
EXP

o,p'-DDT results in increased expression of MYO5B mRNA

NCBI chr18:70,313,717...70,613,918
Ensembl chr18:70,311,990...70,613,918

G

NLR family, apoptosis inhibitory protein 6

increases expression

EXP

o,p'-DDT analog results in increased expression of NAIP2 mRNA

NCBI chr 2:33,241,520...33,293,184
Ensembl chr 2:33,241,521...33,276,859

G

neutrophil cytosolic factor 1

increases expression
multiple interactions

ISO

o,p'-DDT results in increased expression of NCF1 mRNA
Quercetin inhibits the reaction [o,p'-DDT results in increased expression of NCF1 mRNA]

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079

G

neutrophil cytosolic factor 2

multiple interactions
increases expression

ISO

Quercetin inhibits the reaction [o,p'-DDT results in increased expression of NCF2 mRNA]

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149

G

neutrophil cytosolic factor 4

multiple interactions
increases expression

ISO

Quercetin inhibits the reaction [o,p'-DDT results in increased expression of NCF4 mRNA]

NCBI chr 7:111,705,926...111,723,893
Ensembl chr 7:111,706,520...111,723,898

G

nuclear receptor coactivator 1

multiple interactions

ISO

o,p'-DDT promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]

NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924

G

NADH:ubiquinone oxidoreductase subunit A1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of NDUFA1 mRNA

NCBI chr X:116,424,223...116,427,875
Ensembl chr X:121,289,925...121,293,555

G

NADH:ubiquinone oxidoreductase subunit S5

increases expression

ISO
EXP

o,p'-DDT results in increased expression of NDUFS5 mRNA

NCBI chr 5:135,974,029...135,979,705
Ensembl chr 2:184,849,197...185,028,909
Ensembl chr 5:184,849,197...185,028,909
Ensembl chr14:184,849,197...185,028,909

G

NADH:ubiquinone oxidoreductase core subunit V2

increases expression

ISO
EXP

o,p'-DDT results in increased expression of NDUFV2 mRNA

NCBI chr 9:113,137,305...113,157,571
Ensembl chr 9:113,137,306...113,157,520

G

nei-like DNA glycosylase 2

increases expression

ISO

o,p'-DDT results in increased expression of NEIL2 mRNA

NCBI chr15:37,444,676...37,454,863
Ensembl chr15:41,621,352...41,630,834

G

nuclear factor kappa B subunit 1

increases expression

EXP

o,p'-DDT analog results in increased expression of NFKB1 mRNA; o,p'-DDT results in increased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

niban apoptosis regulator 1

increases expression

ISO

o,p'-DDT results in increased expression of NIBAN1 mRNA

NCBI chr13:63,674,240...63,827,748
Ensembl chr13:66,224,021...66,377,724

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

ISO

o,p'-DDT results in increased expression of NME1 mRNA

NCBI chr10:79,403,939...79,426,620
Ensembl chr10:79,403,940...79,413,310

G

nucleolar protein 3

increases expression

EXP

o,p'-DDT analog results in increased expression of NOL3 mRNA; o,p'-DDT results in increased expression of NOL3 mRNA

NCBI chr19:50,066,493...50,068,175
Ensembl chr19:50,063,986...50,068,722

G

nitric oxide synthase 2

multiple interactions
increases expression

ISO

[DDT co-treated with o,p'-DDT] results in decreased expression of NOS2 mRNA
o,p'-DDT results in increased expression of NOS2

PMID:12007859 PMID:15104118

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

notch receptor 1

multiple interactions

ISO

MAPK1 protein promotes the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]; MAPK14 protein promotes the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]; o,p'-DDT results in increased phosphorylation of and results in increased activity of NOTCH1 protein; SB 203580 inhibits the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]; U 0126 inhibits the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613

G

NADPH oxidase 1

multiple interactions
increases expression

ISO

Quercetin inhibits the reaction [o,p'-DDT results in increased expression of NOX1 mRNA]

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:101,572,340...101,595,520

G

NPC intracellular cholesterol transporter 1

increases expression

ISO

o,p'-DDT results in increased expression of NPC1 mRNA

NCBI chr18:3,654,237...3,699,853
Ensembl chr18:3,654,237...3,699,800

G

NAD(P)H quinone dehydrogenase 1

affects expression

ISO

o,p'-DDT affects the expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
affects expression
increases activity

ISO
EXP

o,p'-DDT binds to and results in increased activity of NR1I2 protein
o,p'-DDT affects the expression of NR1I2 mRNA
o,p'-DDT results in increased activity of NR1I2 protein

PMID:15548381 PMID:16054614 PMID:17984292 PMID:18925944 PMID:21115097 More...

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

affects expression
multiple interactions
increases activity

ISO
EXP

o,p'-DDT affects the expression of NR1I3 mRNA
o,p'-DDT inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]; o,p'-DDT promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
o,p'-DDT results in increased activity of NR1I3 protein

PMID:10037683 PMID:17984292 PMID:18925944 PMID:21924250 PMID:26187274 More...

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

ISO

o,p'-DDT inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein]

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions

ISO

o,p'-DDT inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; o,p'-DDT inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]

NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078

G

out at first homolog

increases expression

ISO

o,p'-DDT results in increased expression of OAF mRNA

NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:52,491,315...52,509,285

G

olfactomedin 1

increases expression

ISO

o,p'-DDT results in increased expression of OLFM1 mRNA

NCBI chr 3:31,918,512...31,956,261
Ensembl chr 3:31,918,573...31,956,260

G

olfactomedin-like 3

increases expression

ISO

o,p'-DDT results in increased expression of OLFML3 mRNA

NCBI chr 2:193,932,665...193,935,494
Ensembl chr 2:193,932,665...193,935,494

G

oxysterol binding protein-like 1A

affects expression

EXP

o,p'-DDT affects the expression of OSBPL1A mRNA

NCBI chr18:3,904,006...4,094,635
Ensembl chr18:4,179,631...4,369,421

G

osteoclast associated Ig-like receptor

increases expression

ISO

o,p'-DDT results in increased expression of OSCAR mRNA

NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:74,515,001...74,529,119

G

poly(A) binding protein, cytoplasmic 1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of PABPC1 mRNA

NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:69,663,068...69,675,050

G

poly (ADP-ribose) polymerase 1

affects expression

EXP

o,p'-DDT affects the expression of PARP1 mRNA

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

EXP

o,p'-DDT inhibits the reaction [Hydrocortisone results in increased expression of PCK1 mRNA]

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

programmed cell death 2

increases expression

EXP
ISO

o,p'-DDT results in increased expression of PDCD2 mRNA

NCBI chr 1:56,484,947...56,490,437
Ensembl chr 1:65,158,034...65,163,524

G

programmed cell death 5

increases expression

ISO
EXP

o,p'-DDT results in increased expression of PDCD5 mRNA

NCBI chr 1:88,305,869...88,311,200
Ensembl chr 1:97,442,755...97,449,844

G

programmed cell death 7

increases expression

ISO

o,p'-DDT results in increased expression of PDCD7 mRNA

NCBI chr 8:74,757,768...74,772,495
Ensembl chr 8:74,757,768...74,781,634

G

pellino E3 ubiquitin protein ligase 1

decreases expression

ISO

o,p'-DDT results in decreased expression of PELI1 mRNA

NCBI chr14:99,455,970...99,510,474
Ensembl chr14:99,455,811...99,510,466

G

progesterone receptor

multiple interactions
affects binding
increases expression
decreases expression

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of PGR mRNA]; o,p'-DDT inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; o,p'-DDT inhibits the reaction [Progesterone binds to PGR protein]; o,p'-DDT inhibits the reaction [Progesterone results in increased expression of PGR protein]
o,p'-DDT binds to PGR protein
o,p'-DDT results in decreased expression of PGR mRNA
o,p'-DDT promotes the reaction [Progesterone binds to PGR protein]

PMID:7414049 PMID:9607801 PMID:10822019 PMID:11867264 PMID:14579009 More...

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

phosphatidylinositol 4-kinase alpha

increases activity

ISO

o,p'-DDT results in increased activity of PI4KA protein

NCBI chr11:97,113,390...97,234,374
Ensembl chr11:97,113,245...97,228,315

G

protein inhibitor of activated STAT, 2

increases expression

ISO
EXP

o,p'-DDT results in increased expression of PIAS2 mRNA

NCBI chr18:70,608,034...70,714,295
Ensembl chr18:72,882,890...73,006,662

G

Pim-1 proto-oncogene, serine/threonine kinase

increases expression

ISO

o,p'-DDT results in increased expression of PIM1 mRNA

NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,556,113...7,561,764

G

pyruvate kinase M1/2

increases expression

ISO

o,p'-DDT results in increased expression of PKM mRNA

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

phospholipase A2, group III

decreases expression

ISO

o,p'-DDT results in decreased expression of PLA2G3 mRNA

NCBI chr14:82,589,908...82,597,542
Ensembl chr14:82,591,862...82,597,542

G

phospholipid phosphatase related 2

increases expression

ISO

o,p'-DDT results in increased expression of PLPPR2 mRNA

NCBI chr 8:20,467,071...20,479,474
Ensembl chr 8:28,745,639...28,755,555

G

DNA polymerase beta

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of POLB mRNA
o,p'-DDT results in increased expression of POLB mRNA

NCBI chr16:69,379,438...69,402,710
Ensembl chr16:76,081,864...76,108,180

G

cytochrome p450 oxidoreductase

affects expression

EXP

o,p'-DDT affects the expression of POR mRNA

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

peroxiredoxin 2

decreases expression

EXP

o,p'-DDT analog results in decreased expression of PRDX2 mRNA; o,p'-DDT results in decreased expression of PRDX2 mRNA

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

protein kinase cAMP-activated catalytic subunit alpha

increases activity
decreases activity

ISO
EXP

o,p'-DDT results in increased activity of PRKACA protein
o,p'-DDT results in decreased activity of PRKACA protein

PMID:19526567 PMID:23209616

NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494

G

protein kinase cAMP-dependent type II regulatory subunit alpha

increases expression

ISO

o,p'-DDT results in increased expression of PRKAR2A mRNA

NCBI chr 8:118,271,608...118,337,332
Ensembl chr 8:118,274,167...118,337,330

G

prolactin

multiple interactions
increases secretion
increases expression

EXP
ISO

Nifedipine inhibits the reaction [o,p'-DDT results in increased secretion of PRL protein]
ICI 164384 inhibits the reaction [o,p'-DDT results in increased expression of PRL mRNA]

PMID:8968093 PMID:15811834

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

prolactin receptor

decreases expression
increases expression

EXP
ISO

o,p'-DDT analog results in decreased expression of PRLR mRNA
o,p'-DDT results in increased expression of PRLR mRNA
o,p'-DDT results in decreased expression of PRLR mRNA

PMID:22937105 PMID:33728745

NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882

G

prokineticin 2

decreases expression

EXP

o,p'-DDT analog results in decreased expression of PROK2 mRNA

NCBI chr 4:133,903,210...133,918,126
Ensembl chr 4:133,903,210...133,917,933

G

pre-mRNA processing factor 8

increases expression

ISO
EXP

o,p'-DDT results in increased expression of PRPF8 mRNA

NCBI chr10:60,331,494...60,354,606
Ensembl chr10:60,829,778...60,852,887

G

proteasome 20S subunit alpha 4

increases expression
affects expression

ISO
EXP

o,p'-DDT results in increased expression of PSMA4 mRNA
o,p'-DDT affects the expression of PSMA4 mRNA

PMID:17984292 PMID:24096037

NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:64,236,783...64,243,979

G

proteasome 20S subunit alpha 5

affects expression

EXP

o,p'-DDT affects the expression of PSMA5 mRNA

NCBI chr 2:198,584,502...198,607,867
Ensembl chr 2:198,584,505...198,607,867

G

proteasome 20S subunit alpha 6

affects expression

EXP

o,p'-DDT affects the expression of PSMA6 mRNA

NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:78,500,736...78,531,717

G

proteasome 20S subunit beta 1

affects expression
increases expression

EXP
ISO

o,p'-DDT affects the expression of PSMB1 mRNA
o,p'-DDT results in increased expression of PSMB1 mRNA

PMID:17984292 PMID:24096037

NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:65,114,724...65,136,640

G

proteasome 20S subunit beta 4

affects expression

EXP

o,p'-DDT affects the expression of PSMB4 mRNA

NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:185,131,786...185,135,287

G

proteasome 20S subunit beta 5

increases expression
affects expression

ISO
EXP

o,p'-DDT results in increased expression of PSMB5 mRNA
o,p'-DDT affects the expression of PSMB5 mRNA

PMID:17984292 PMID:24096037

NCBI chr15:28,072,772...28,077,367
Ensembl chr15:32,042,787...32,047,379

G

proteasome 26S subunit, ATPase 3

affects expression

EXP

o,p'-DDT affects the expression of PSMC3 mRNA

NCBI chr 3:97,487,643...97,493,025
Ensembl chr 3:97,487,632...97,499,176

G

proteasome 26S subunit, ATPase 4

affects expression

EXP

o,p'-DDT affects the expression of PSMC4 mRNA

NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:92,476,690...92,485,060

G

proteasome 26S subunit, ATPase 5

increases expression

ISO
EXP

o,p'-DDT results in increased expression of PSMC5 mRNA

NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921

G

proteasome 26S subunit, non-ATPase 1

affects expression

EXP

o,p'-DDT affects the expression of PSMD1 mRNA

NCBI chr 9:86,709,714...86,785,213
Ensembl chr 9:94,157,971...94,233,218

G

proteasome 26S subunit, non-ATPase 12

affects expression

EXP

o,p'-DDT affects the expression of PSMD12 mRNA

NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,901,133...92,988,964

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 2

increases expression
affects expression

ISO
EXP

o,p'-DDT results in increased expression of PSMD2 mRNA
o,p'-DDT affects the expression of PSMD2 mRNA

PMID:17984292 PMID:24096037

NCBI chr11:80,248,364...80,258,991
Ensembl chr11:93,752,763...93,763,388

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 4

affects expression

EXP

o,p'-DDT affects the expression of PSMD4 mRNA

NCBI chr 2:185,287,941...185,297,238
Ensembl chr 2:185,286,868...185,297,201

G

proteasome 26S subunit, non-ATPase 8

affects expression

EXP

o,p'-DDT affects the expression of PSMD8 mRNA

NCBI chr 1:84,474,377...84,481,209
Ensembl chr 1:93,601,853...93,608,689

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression
decreases expression

ISO
EXP

6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased susceptibility to o,p'-DDT; [o,p'-DDT results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]
o,p'-DDT results in increased expression of PTGS2 mRNA; o,p'-DDT results in increased expression of PTGS2 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; [o,p'-DDT results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]
o,p'-DDT results in decreased expression of PTGS2 mRNA
[o,p'-DDT results in decreased expression of PTGS2 mRNA] which results in decreased abundance of Dinoprostone

PMID:18840457 PMID:20678559 PMID:23209616

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine phosphatase, receptor type, C

increases expression

ISO
EXP

o,p'-DDT results in increased expression of PTPRC mRNA

NCBI chr13:52,147,717...52,259,810
Ensembl chr13:52,147,717...52,259,746

G

PYD and CARD domain containing

decreases expression

EXP

o,p'-DDT analog results in decreased expression of PYCARD mRNA

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419

G

RAB3A interacting protein-like 1

increases expression

ISO

o,p'-DDT results in increased expression of RAB3IL1 mRNA

NCBI chr 1:216,071,043...216,107,609
Ensembl chr 1:216,071,084...216,107,609

G

RAN, member RAS oncogene family

affects expression

EXP

o,p'-DDT affects the expression of RAN mRNA

NCBI chr12:33,311,155...33,314,339
Ensembl chr12:33,311,158...33,314,317

G

RNA binding protein, mRNA processing factor

decreases expression

ISO

o,p'-DDT results in decreased expression of RBPMS mRNA

NCBI chr16:64,942,159...65,098,504
Ensembl chr16:64,942,530...65,098,503

G

RecQ like helicase 4

increases methylation

ISO

o,p'-DDT results in increased methylation of RECQL4 gene

NCBI chr 7:110,304,092...110,311,426
Ensembl chr 7:110,304,094...110,311,258

G

RELA proto-oncogene, NF-kB subunit

affects localization

ISO

o,p'-DDT affects the localization of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

arginine-glutamic acid dipeptide repeats

decreases expression

ISO
EXP

o,p'-DDT results in decreased expression of RERE mRNA

NCBI chr 5:166,048,770...166,380,559
Ensembl chr 5:166,048,844...166,380,558

G

similar to RIKEN cDNA 3110043O21

increases expression

ISO

o,p'-DDT results in increased expression of C9ORF72 mRNA

NCBI chr 5:54,562,570...54,587,649
Ensembl chr 5:54,562,570...54,587,637

G

receptor-interacting serine-threonine kinase 2

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of RIPK2 mRNA
o,p'-DDT analog results in decreased expression of RIPK2 mRNA

NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663

G

RecQ mediated genome instability 2

decreases expression

ISO

o,p'-DDT results in decreased expression of RMI2 mRNA

NCBI chr10:4,829,333...4,837,264
Ensembl chr10:5,338,060...5,344,235

G

ribosomal protein L13

affects expression

EXP

o,p'-DDT affects the expression of RPL13 mRNA

NCBI chr19:51,153,990...51,156,541
Ensembl chr19:68,062,493...68,065,059

G

ribosomal protein L18

affects expression

EXP

o,p'-DDT affects the expression of RPL18 mRNA

NCBI chr 1:96,188,811...96,191,452
Ensembl chr 1:105,325,250...105,327,910

G

ribosomal protein L23

affects expression

EXP

o,p'-DDT affects the expression of RPL23 mRNA

NCBI chr10:82,771,878...82,775,840
Ensembl chr10:83,262,592...83,272,214

G

ribosomal protein L3

affects expression

EXP

o,p'-DDT affects the expression of RPL3 mRNA

NCBI chr 7:111,622,255...111,627,640
Ensembl chr 7:113,501,960...113,507,990

G

ribosomal protein L37

affects expression

EXP

o,p'-DDT affects the expression of RPL37 mRNA

NCBI chr 2:54,215,469...54,217,429
Ensembl chr 2:55,942,945...55,944,900

G

ribosomal protein L6

affects expression

EXP

o,p'-DDT affects the expression of RPL6 mRNA

NCBI chr12:35,347,493...35,352,011
Ensembl chr12:41,008,142...41,025,733

G

ribosomal protein S15a

affects expression

EXP

o,p'-DDT affects the expression of RPS15A mRNA

NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:181,854,396...181,861,201

G

ribosomal protein S17

affects expression

EXP

o,p'-DDT affects the expression of RPS17 mRNA

NCBI chr 1:135,295,920...135,298,506
Ensembl chr 1:144,705,149...144,707,734
Ensembl chr 8:144,705,149...144,707,734

G

ribosomal protein S20

affects expression

EXP

o,p'-DDT affects the expression of RPS20 mRNA

NCBI chr 5:16,819,095...16,820,476
Ensembl chr 3:42,839,965...43,095,621
Ensembl chr 9:42,839,965...43,095,621
Ensembl chr 5:42,839,965...43,095,621

G

ribosomal protein S3

affects expression

EXP

o,p'-DDT affects the expression of RPS3 mRNA

NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:163,189,842...163,195,776

G

ribosomal protein S5

affects expression

EXP

o,p'-DDT affects the expression of RPS5 mRNA

NCBI chr 1:73,538,776...73,543,073
Ensembl chr 1:82,610,965...82,615,262

G

ribosomal protein S6

affects expression

EXP

o,p'-DDT affects the expression of RPS6 mRNA

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566

G

ribosomal protein S8

affects expression

EXP

o,p'-DDT affects the expression of RPS8 mRNA

NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:135,866,941...135,869,548

G

ribosomal protein SA

affects expression

EXP

o,p'-DDT affects the expression of RPSA mRNA

NCBI chr 8:128,728,761...128,732,736
Ensembl chr 8:128,728,862...128,732,737

G

ribonucleotide reductase regulatory subunit M2

decreases expression

ISO

o,p'-DDT results in decreased expression of RRM2 mRNA

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370

G

RUNX family transcription factor 1

decreases expression

EXP

o,p'-DDT results in decreased expression of RUNX1 mRNA

NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925

G

sphingosine-1-phosphate receptor 3

increases expression

ISO

o,p'-DDT results in increased expression of S1PR3 mRNA

NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,928,444...13,947,197

G

Sin3A associated protein 18

increases expression

EXP
ISO

o,p'-DDT results in increased expression of SAP18 mRNA

NCBI chr15:31,943,228...31,947,534
Ensembl chr10:87,156,914...87,158,257
Ensembl chr15:87,156,914...87,158,257

G

secretoglobin, family 1D, member 2

increases expression

ISO

o,p'-DDT results in increased expression of SCGB1D2 mRNA

NCBI chr 1:206,228,546...206,233,587
Ensembl chr 1:215,653,464...215,656,710

G

serpin family A member 3N

increases expression

ISO

o,p'-DDT results in increased expression of SERPINA3 mRNA

NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415

G

serpin family B member 5

increases expression

ISO

o,p'-DDT results in increased expression of SERPINB5 mRNA

NCBI chr13:23,500,203...23,520,401
Ensembl chr13:23,500,198...23,520,400

G

SERTA domain containing 2

increases expression

ISO
EXP

o,p'-DDT results in increased expression of SERTAD2 mRNA

NCBI chr14:94,733,637...94,838,200
Ensembl chr14:98,934,769...99,041,468

G

sestrin 2

increases expression

ISO

o,p'-DDT results in increased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:149,986,317...150,005,255

G

splicing factor 1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of SF1 mRNA

NCBI chr 1:213,090,256...213,112,688
Ensembl chr 1:213,099,260...213,113,590

G

splicing factor 3b, subunit 3

increases expression

ISO
EXP

o,p'-DDT results in increased expression of SF3B3 mRNA

NCBI chr19:55,692,124...55,729,640
Ensembl chr19:55,692,126...55,729,621

G

splicing factor 3b, subunit 5

increases expression

ISO

o,p'-DDT results in increased expression of SF3B5 mRNA

NCBI chr 1:7,357,040...7,357,752
Ensembl chr 1:9,177,098...9,177,900

G

splicing factor proline and glutamine rich

increases expression

ISO
EXP

o,p'-DDT results in increased expression of SFPQ mRNA

NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:144,622,476...144,637,926

G

shugoshin 2

decreases expression

ISO

o,p'-DDT results in decreased expression of SGO2 mRNA

NCBI chr 9:59,548,605...59,573,229
Ensembl chr 9:67,042,833...67,068,152

G

sex hormone binding globulin

multiple interactions
affects binding

EXP
ISO

o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]
o,p'-DDT binds to SHBG protein

PMID:9171990 PMID:25349334

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

siah E3 ubiquitin protein ligase 2

increases expression

ISO

o,p'-DDT results in increased expression of SIAH2 mRNA

NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:145,063,857...145,081,873

G

solute carrier family 10 member 1

decreases expression

ISO

o,p'-DDT results in decreased expression of SLC10A1 mRNA

NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944

G

solute carrier family 12 member 2

multiple interactions

ISO

[o,p'-DDT co-treated with DDT] results in increased expression of SLC12A2 mRNA

NCBI chr18:53,546,263...53,614,478
Ensembl chr18:53,546,333...53,614,470

G

solute carrier family 1 member 5

increases expression

ISO

o,p'-DDT results in increased expression of SLC1A5 mRNA

NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:86,584,949...86,599,054

G

solute carrier family 22 member 1

decreases expression

ISO

o,p'-DDT results in decreased expression of SLC22A1 mRNA

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 31 member 1

increases expression

ISO

o,p'-DDT results in increased expression of SLC31A1 mRNA

NCBI chr 5:80,830,574...80,859,810
Ensembl chr 5:80,830,389...80,859,809

G

solute carrier family 35, member F5

increases expression

ISO

o,p'-DDT results in increased expression of SLC35F5 mRNA

NCBI chr13:36,992,118...37,028,549
Ensembl chr13:39,544,757...39,581,223

G

solute carrier family 38, member 1

increases expression

ISO

o,p'-DDT results in increased expression of SLC38A1 mRNA

NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:129,617,387...129,681,778

G

solute carrier family 7 member 5

increases expression

ISO

o,p'-DDT results in increased expression of SLC7A5 mRNA

NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412

G

solute carrier family 8 member A1

multiple interactions

ISO

[o,p'-DDT co-treated with DDT] results in increased expression of SLC8A1 mRNA

NCBI chr 6:18,975,498...19,299,704
Ensembl chr 6:18,946,798...19,287,964

G

solute carrier family 9 member A1

multiple interactions

ISO

[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A1 mRNA

NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517

G

solute carrier family 9 member A2

multiple interactions

ISO

[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A2 mRNA

NCBI chr 9:42,932,001...43,014,447
Ensembl chr 9:50,426,798...50,510,040

G

solute carrier family 9 member A3

multiple interactions

ISO

[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A3 mRNA

NCBI chr 1:30,953,215...30,996,209
Ensembl chr 1:30,953,216...30,996,002

G

solute carrier organic anion transporter family, member 2a1

increases expression

ISO

o,p'-DDT results in increased expression of SLCO2A1 mRNA

NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:112,467,160...112,551,921

G

survival of motor neuron 1, telomeric

increases expression

ISO
EXP

o,p'-DDT results in increased expression of SMN1 mRNA

NCBI chr 2:33,224,115...33,235,162
Ensembl chr 2:33,224,095...33,235,162

G

survival motor neuron domain containing 1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of SMNDC1 mRNA

NCBI chr 1:252,389,675...252,400,749
Ensembl chr 1:262,386,590...262,405,707

G

superoxide dismutase 1

increases expression
decreases expression

EXP

o,p'-DDT analog results in increased expression of SOD1 mRNA
o,p'-DDT results in decreased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

decreases expression

EXP

o,p'-DDT analog results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

SPC25 component of NDC80 kinetochore complex

decreases expression

ISO

o,p'-DDT results in decreased expression of SPC25 mRNA

NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:74,383,548...74,396,718

G

sphingosine kinase 2

increases expression
decreases expression

ISO
EXP

o,p'-DDT results in increased expression of SPHK2 mRNA
o,p'-DDT analog results in decreased expression of SPHK2 mRNA; o,p'-DDT results in decreased expression of SPHK2 mRNA

PMID:22937105 PMID:24096037

NCBI chr 1:105,317,332...105,324,985
Ensembl chr 1:105,317,333...105,321,637

G

spectrin, beta, non-erythrocytic 1

decreases expression

ISO
EXP

o,p'-DDT results in decreased expression of SPTBN1 mRNA

NCBI chr14:108,042,629...108,217,884
Ensembl chr14:108,042,629...108,217,836

G

squalene epoxidase

decreases expression

ISO

o,p'-DDT results in decreased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:92,757,409...92,773,050

G

sterol regulatory element binding transcription factor 1

affects expression

ISO
EXP

o,p'-DDT affects the expression of SREBF1 mRNA

PMID:17984292 PMID:18925944

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

ST14 transmembrane serine protease matriptase

increases expression

ISO
EXP

o,p'-DDT results in increased expression of ST14 mRNA

NCBI chr 8:37,798,994...37,839,881
Ensembl chr 8:37,798,995...37,855,652

G

steroidogenic acute regulatory protein

decreases expression

EXP

o,p'-DDT results in decreased expression of STAR mRNA

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

stanniocalcin 2

increases expression

ISO

o,p'-DDT results in increased expression of STC2 mRNA

NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447

G

stathmin 1

affects expression

ISO
EXP

o,p'-DDT affects the expression of STMN1 mRNA

PMID:17984292 PMID:18925944

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842

G

sulfotransferase family 1E member 1

decreases expression

EXP

o,p'-DDT results in decreased expression of SULT1E1 mRNA

NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716

G

TATA-box binding protein associated factor 9b

increases expression

EXP
ISO

o,p'-DDT results in increased expression of TAF9B mRNA

NCBI chr X:71,289,290...71,300,142
Ensembl chr X:75,354,825...75,366,414

G

tyrosine aminotransferase

multiple interactions

EXP

o,p'-DDT inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA]

NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482

G

t-complex 1

increases expression

EXP
ISO

o,p'-DDT results in increased expression of TCP1 mRNA

NCBI chr 1:50,376,848...50,384,527
Ensembl chr 1:50,376,848...50,384,527

G

telomerase reverse transcriptase

increases expression

ISO

o,p'-DDT results in increased expression of TERT mRNA

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111

G

transcription factor EC

increases expression

ISO

o,p'-DDT results in increased expression of TFEC mRNA

NCBI chr 4:45,106,129...45,180,236
Ensembl chr 4:46,073,605...46,146,200

G

trefoil factor 1

multiple interactions
increases expression

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]

PMID:8968093 PMID:18700809 PMID:20206645 PMID:22609851 PMID:23478948

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

trefoil factor 2

decreases expression

ISO

o,p'-DDT results in decreased expression of TFF2 mRNA

NCBI chr20:9,217,110...9,220,979
Ensembl chr20:9,217,121...9,220,979

G

transforming growth factor alpha

increases expression

ISO

o,p'-DDT results in increased expression of TGFA mRNA

NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339

G

transforming growth factor, beta 2

decreases expression

ISO

o,p'-DDT results in decreased expression of TGFB2 mRNA

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856

G

thrombomodulin

increases expression

ISO

o,p'-DDT results in increased expression of THBD mRNA

NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:156,306,632...156,320,582

G

thrombospondin 1

increases expression

ISO

o,p'-DDT results in increased expression of THBS1 mRNA

NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402

G

thyroid hormone receptor beta

multiple interactions

ISO

o,p'-DDT binds to and results in increased activity of THRB protein

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

TIMP metallopeptidase inhibitor 1

decreases expression

ISO

o,p'-DDT results in decreased expression of TIMP1 mRNA

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

TIMP metallopeptidase inhibitor 2

decreases expression

ISO

o,p'-DDT results in decreased expression of TIMP2 mRNA

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

transmembrane p24 trafficking protein 4

decreases expression

ISO

o,p'-DDT results in decreased expression of TMED4 mRNA

NCBI chr14:81,125,049...81,129,646
Ensembl chr14:85,338,980...85,343,577

G

tumor necrosis factor

multiple interactions
decreases expression
increases expression

ISO
EXP

[DDT co-treated with o,p'-DDT] results in decreased expression of TNF mRNA
o,p'-DDT analog results in decreased expression of TNF mRNA
o,p'-DDT results in increased expression of TNF mRNA

PMID:12007859 PMID:15104118 PMID:22937105

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 10b

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of TNFRSF10B mRNA
o,p'-DDT analog results in decreased expression of TNFRSF10B mRNA

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082

G

TNF receptor superfamily member 11B

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of TNFRSF11B mRNA
o,p'-DDT analog results in decreased expression of TNFRSF11B mRNA

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF receptor superfamily member 14

increases expression

ISO

o,p'-DDT results in increased expression of TNFRSF14 mRNA

NCBI chr 5:170,768,413...170,776,749
Ensembl chr 5:170,768,416...170,776,046

G

TNF receptor superfamily member 19

affects expression

ISO

o,p'-DDT affects the expression of TNFRSF19 mRNA

NCBI chr15:39,268,305...39,334,566
Ensembl chr15:39,268,305...39,356,438

G

TNF receptor superfamily member 1A

increases expression

EXP

o,p'-DDT results in increased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF receptor superfamily member 1B

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of TNFRSF1B mRNA
o,p'-DDT analog results in increased expression of TNFRSF1B mRNA; o,p'-DDT results in increased expression of TNFRSF1B mRNA

NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411

G

TNF superfamily member 10

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of TNFSF10 mRNA
o,p'-DDT analog results in decreased expression of TNFSF10 mRNA

NCBI chr 2:112,136,550...112,155,903

G

TNF superfamily member 12

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of TNFSF12 mRNA
o,p'-DDT analog results in decreased expression of TNFSF12 mRNA

NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,902,616...54,911,913

G

translocase of outer mitochondrial membrane 20

increases expression

EXP
ISO

o,p'-DDT results in increased expression of TOMM20 mRNA

NCBI chr19:71,822,429...71,832,420
Ensembl chr19:71,822,411...71,832,510

G

tumor protein p53

increases expression

EXP

o,p'-DDT analog results in increased expression of TP53 mRNA; o,p'-DDT analog results in increased expression of TP53 protein; o,p'-DDT results in increased expression of TP53 mRNA; o,p'-DDT results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 binding protein, 2

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of TP53BP2 mRNA
o,p'-DDT analog results in decreased expression of TP53BP2 mRNA

NCBI chr13:96,620,429...96,677,090
Ensembl chr13:96,620,428...96,677,616

G

tumor protein p63

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of TP63 mRNA
o,p'-DDT analog results in decreased expression of TP63 mRNA

NCBI chr11:88,343,647...88,554,543
Ensembl chr11:88,343,651...88,554,177

G

tumor protein p73

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of TP73 mRNA
o,p'-DDT analog results in decreased expression of TP73 mRNA

NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:169,903,801...169,963,552

G

TNFRSF1A-associated via death domain

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of TRADD mRNA
o,p'-DDT analog results in decreased expression of TRADD mRNA

NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550

G

Tnf receptor-associated factor 2

increases expression
decreases expression

EXP

o,p'-DDT results in increased expression of TRAF2 mRNA
o,p'-DDT analog results in decreased expression of TRAF2 mRNA

NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691

G

Tnf receptor-associated factor 3

increases expression

EXP

o,p'-DDT results in increased expression of TRAF3 mRNA

NCBI chr 6:136,025,097...136,128,363
Ensembl chr 6:136,027,157...136,128,363

G

Tnf receptor associated factor 4

decreases expression
increases expression

EXP

o,p'-DDT analog results in decreased expression of TRAF4 mRNA
o,p'-DDT results in increased expression of TRAF4 mRNA

NCBI chr10:63,552,251...63,558,356
Ensembl chr10:63,552,253...63,558,356

G

TSC22 domain family, member 1

decreases expression

ISO

o,p'-DDT results in decreased expression of TSC22D1 mRNA

NCBI chr15:58,159,612...58,260,244
Ensembl chr15:58,159,952...58,183,322

G

TSC22 domain family, member 3

multiple interactions

ISO

o,p'-DDT inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:109,006,420...109,015,519

G

tsukushi, small leucine rich proteoglycan

increases expression

ISO

o,p'-DDT results in increased expression of TSKU mRNA

NCBI chr 1:162,071,459...162,082,972
Ensembl chr 1:162,064,126...162,089,272

G

tetraspanin 10

increases expression

ISO

o,p'-DDT results in increased expression of TSPAN10 mRNA

NCBI chr10:105,715,803...105,721,503
Ensembl chr10:106,214,208...106,219,085

G

tetraspanin 12

decreases expression

ISO

o,p'-DDT results in decreased expression of TSPAN12 mRNA

NCBI chr 4:51,279,562...51,355,030
Ensembl chr 4:51,279,563...51,355,030

G

tubulin, beta 2B class IIb

increases expression

ISO
EXP

o,p'-DDT results in increased expression of TUBB2B mRNA

NCBI chr17:30,953,086...30,956,133
Ensembl chr17:30,952,923...30,955,990

G

tubulin, beta 5 class I

increases expression

ISO
EXP

o,p'-DDT results in increased expression of TUBB5 mRNA

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726

G

thioredoxin 1

affects expression

EXP

o,p'-DDT affects the expression of TXN1 mRNA

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin interacting protein

decreases expression

ISO

o,p'-DDT results in decreased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

thioredoxin reductase 1

affects expression

EXP

o,p'-DDT affects the expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

ubiquitin-conjugating enzyme E2F (putative)

increases expression

EXP
ISO

o,p'-DDT results in increased expression of UBE2F mRNA

NCBI chr 9:99,293,506...99,328,690
Ensembl chr 9:99,293,515...99,330,479

G

ubiquitin-conjugating enzyme E2L 3

increases expression

EXP
ISO

o,p'-DDT results in increased expression of UBE2L3 mRNA

NCBI chr11:83,797,722...83,838,862
Ensembl chr11:97,301,945...97,343,084

G

ubiquitin specific peptidase 1

increases expression

ISO
EXP

o,p'-DDT results in increased expression of USP1 mRNA

NCBI chr 5:113,587,564...113,598,934
Ensembl chr 5:118,702,868...118,714,434

G

valosin containing protein lysine methyltransferase

decreases expression

ISO

o,p'-DDT results in decreased expression of VCPKMT mRNA

NCBI chr 6:88,036,485...88,042,151
Ensembl chr 6:93,772,575...93,777,975

G

vascular endothelial growth factor A

increases expression

ISO

o,p'-DDT results in increased expression of VEGFA mRNA

PMID:22609851 PMID:33728745

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

X-linked inhibitor of apoptosis

decreases expression

EXP

o,p'-DDT analog results in decreased expression of XIAP mRNA

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978

G

zinc finger protein, multitype 2

increases methylation

ISO

o,p'-DDT results in increased methylation of ZFPM2 gene

NCBI chr 7:73,563,732...74,001,041
Ensembl chr 7:73,563,732...74,001,041

G

zinc finger with KRAB and SCAN domains 2

increases expression

ISO

o,p'-DDT results in increased expression of ZKSCAN2 mRNA

NCBI chr 1:178,006,003...178,028,239
Ensembl chr 1:187,440,330...187,458,985

G

zinc finger MYM-type containing 3

increases expression

ISO

o,p'-DDT results in increased expression of ZMYM3 mRNA

NCBI chr X:66,528,585...66,544,234
Ensembl chr X:70,568,573...70,584,768

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
chemical entity	20860
group	20803
polyatomic entity	20803
molecule	20674
cyclic compound	20429
organic cyclic compound	20404
organic aromatic compound	20237
diarylmethane	10899
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane	475
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
main group element atom	20781
p-block element atom	20781
p-block molecular entity	20781
carbon group molecular entity	20715
organic molecular entity	20710
organic molecule	20654
organic cyclic compound	20404
organic aromatic compound	20237
diarylmethane	10899
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane	475

paths to the root