1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane	go back to main search page
Accession:	CHEBI:34027	browse the term
Definition:	A diarylmethane that has formula C14H9Cl5.
Synonyms:	related_synonym:	2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1,1-trichloroethane; Formula=C14H9Cl5; InChI=1S/C14H9Cl5/c15-10-7-5-9(6-8-10)13(14(17,18)19)11-3-1-2-4-12(11)16/h1-8,13H; InChIKey=CVUGPAFCQJIYDT-UHFFFAOYSA-N; SMILES=Clc1ccc(cc1)C(c1ccccc1Cl)C(Cl)(Cl)Cl; o,p'-DDT
	xref:	CAS:789-02-6; KEGG:C14187
	xref_mesh:	MESH:C016340
	xref:	PPDB:3141

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Genes (471)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

increases expression

o,p'-DDT results in increased expression of AARS1 mRNA

NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147

G

ATP binding cassette subfamily B member 1A

decreases activity
increases expression

o,p'-DDT results in decreased activity of ABCB1 protein
o,p'-DDT results in increased expression of ABCB1 mRNA

PMID:23169446 PMID:24464585

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 2

increases expression

o,p'-DDT results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily G member 2

increases expression
decreases activity

o,p'-DDT results in increased expression of ABCG2 mRNA
o,p'-DDT results in decreased activity of ABCG2 protein

PMID:23169446 PMID:24464585

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ADAM metallopeptidase with thrombospondin type 1 motif, 9

increases expression

o,p'-DDT results in increased expression of ADAMTS9 mRNA

NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929

G

aryl hydrocarbon receptor

affects expression
multiple interactions
increases expression
decreases methylation

o,p'-DDT affects the expression of AHR mRNA
o,p'-DDT promotes the reaction [AHR protein binds to CYP1A1 promoter]
o,p'-DDT results in increased expression of AHR mRNA; o,p'-DDT results in increased expression of AHR protein
o,p'-DDT results in decreased methylation of AHR gene

PMID:12176094 PMID:18925944 PMID:28263910

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1, member C2

increases expression

o,p'-DDT results in increased expression of AKR1C2 mRNA

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 7, member A2

affects expression

o,p'-DDT affects the expression of AKR7A2 mRNA

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

AKT serine/threonine kinase 1

increases phosphorylation

o,p'-DDT results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member A1

affects expression

o,p'-DDT affects the expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

alpha-kinase 2

decreases expression

o,p'-DDT results in decreased expression of ALPK2 mRNA

NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258

G

alkaline phosphatase, biomineralization associated

multiple interactions

o,p'-DDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

anaphase promoting complex subunit 1

increases expression

o,p'-DDT results in increased expression of ANAPC1 mRNA

NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:115,850,185...115,930,273

G

anoctamin 1

increases expression

o,p'-DDT results in increased expression of ANO1 mRNA

NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069

G

adaptor-related protein complex 1 associated regulatory protein

increases expression

o,p'-DDT results in increased expression of AP1AR mRNA

NCBI chr 2:216,276,631...216,309,020
Ensembl chr 2:216,276,631...216,309,013

G

apoptotic peptidase activating factor 1

decreases expression

o,p'-DDT analog results in decreased expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

apoptosis inhibitor 5

decreases expression

o,p'-DDT analog results in decreased expression of API5 mRNA

NCBI chr 3:80,378,096...80,403,259
Ensembl chr 3:80,378,096...80,403,264

G

APAF1 interacting protein

decreases expression

o,p'-DDT results in decreased expression of APIP mRNA

NCBI chr 3:89,431,964...89,458,000
Ensembl chr 3:89,432,037...89,458,340

G

apolipoprotein A4

affects expression

o,p'-DDT affects the expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

amyloid beta precursor protein

affects expression

o,p'-DDT affects the expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 8

increases expression

o,p'-DDT results in increased expression of AQP8 mRNA

NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158

G

androgen receptor

multiple interactions
affects binding
decreases expression
decreases activity
increases expression

Dihydrotestosterone inhibits the reaction [o,p'-DDT results in increased activity of AR protein]; o,p'-DDT binds to and results in decreased activity of AR protein; o,p'-DDT inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to AR protein]; o,p'-DDT inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; o,p'-DDT inhibits the reaction [Metribolone results in increased activity of AR protein]
o,p'-DDT binds to AR protein
o,p'-DDT results in decreased expression of AR mRNA
o,p'-DDT results in decreased activity of AR protein
o,p'-DDT results in increased expression of AR mRNA

PMID:9705896 PMID:9846162 PMID:10822019 PMID:12676605 PMID:14565775 More...

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arginase 1

multiple interactions

o,p'-DDT inhibits the reaction [Hydrocortisone results in increased expression of ARG1 mRNA]

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

aryl hydrocarbon receptor nuclear translocator

decreases expression

o,p'-DDT results in decreased expression of ARNT mRNA; o,p'-DDT results in decreased expression of ARNT protein

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

aryl hydrocarbon receptor nuclear translocator 2

decreases expression
multiple interactions

o,p'-DDT results in decreased expression of ARNT2 mRNA
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [o,p'-DDT results in decreased expression of ARNT2 mRNA]

NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153

G

actin related protein 2/3 complex, subunit 1A

increases expression

o,p'-DDT results in increased expression of ARPC1A mRNA

NCBI chr12:9,502,496...9,525,304
Ensembl chr12:9,502,501...9,525,330

G

assembly factor for spindle microtubules

decreases expression

o,p'-DDT results in decreased expression of ASPM mRNA

NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755

G

asparaginase and isoaspartyl peptidase 1

increases expression

o,p'-DDT results in increased expression of ASRGL1 mRNA

NCBI chr 1:206,006,103...206,027,115
Ensembl chr 1:206,006,109...206,027,108

G

ATPase family, AAA domain containing 3A

increases expression

o,p'-DDT results in increased expression of ATAD3A mRNA

NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482

G

activating transcription factor 4

increases expression

o,p'-DDT results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions

[o,p'-DDT co-treated with DDT] results in increased expression of ATP1A1 mRNA

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATP synthase F1 subunit beta

increases expression

o,p'-DDT results in increased expression of ATP5F1B mRNA

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

apoptosis and caspase activation inhibitor

increases expression

o,p'-DDT analog results in increased expression of AVEN mRNA; o,p'-DDT results in increased expression of AVEN mRNA

PMID:22937105 PMID:24096037

NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634

G

BCL2-associated agonist of cell death

decreases expression

o,p'-DDT analog results in decreased expression of BAD mRNA; o,p'-DDT results in decreased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 1

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of BAG1 mRNA
o,p'-DDT results in increased expression of BAG1 mRNA

NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075

G

BCL2 associated X, apoptosis regulator

increases expression
decreases expression

o,p'-DDT results in increased expression of BAX mRNA
o,p'-DDT analog results in decreased expression of BAX mRNA
o,p'-DDT results in increased expression of BAX protein

PMID:22937105 PMID:35122929

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL10, immune signaling adaptor

decreases expression

o,p'-DDT results in decreased expression of BCL10 mRNA

NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523

G

BCL2, apoptosis regulator

increases expression
multiple interactions
decreases expression

o,p'-DDT results in increased expression of BCL2 mRNA; o,p'-DDT results in increased expression of BCL2 protein
fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of BCL2 protein]
o,p'-DDT results in decreased expression of BCL2 protein

PMID:10545406 PMID:22609851 PMID:22937105 PMID:35122929

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

increases expression
decreases expression

o,p'-DDT results in increased expression of BCL2A1 mRNA
o,p'-DDT analog results in decreased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

decreases expression

o,p'-DDT analog results in decreased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

Bcl2-like 11

increases expression
decreases expression

o,p'-DDT analog results in increased expression of BCL2L11 mRNA; o,p'-DDT results in increased expression of BCL2L11 mRNA
o,p'-DDT analog results in decreased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

Bcl2-like 2

increases expression
decreases expression

o,p'-DDT results in increased expression of BCL2L2 mRNA
o,p'-DDT analog results in decreased expression of BCL2L2 mRNA

NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624

G

BCL2-associated transcription factor 1

decreases expression

o,p'-DDT analog results in decreased expression of BCLAF1 mRNA

NCBI chr 1:15,088,436...15,117,666
Ensembl chr 1:15,070,894...15,148,832

G

brain expressed X-linked 1

increases expression

o,p'-DDT results in increased expression of BEX2 mRNA

NCBI chr X:99,219,014...99,220,518
Ensembl chr X:99,219,014...99,220,958

G

BH3 interacting domain death agonist

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of BID mRNA
o,p'-DDT results in increased expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

BCL2-interacting killer

increases expression
decreases expression

o,p'-DDT results in increased expression of BIK mRNA
o,p'-DDT analog results in decreased expression of BIK mRNA

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

G

baculoviral IAP repeat-containing 3

increases expression

o,p'-DDT analog results in increased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

decreases expression

o,p'-DDT analog results in decreased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BCL2 interacting protein 1

increases expression
decreases expression

o,p'-DDT results in increased expression of BNIP1 mRNA
o,p'-DDT analog results in decreased expression of BNIP1 mRNA

PMID:19371625 PMID:22937105

NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157

G

BCL2 interacting protein 2

decreases expression

o,p'-DDT analog results in decreased expression of BNIP2 mRNA

NCBI chr 8:70,640,436...70,661,782
Ensembl chr 8:70,640,445...70,675,590

G

BCL2 interacting protein 3

increases expression

o,p'-DDT analog results in increased expression of BNIP3 mRNA; o,p'-DDT results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BCL2 family apoptosis regulator BOK

decreases expression

o,p'-DDT analog results in decreased expression of BOK mRNA

NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476

G

BRCA1, DNA repair associated

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of BRCA1 mRNA]; fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of BRCA1 mRNA]

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

complement C3

increases expression

o,p'-DDT results in increased expression of C3 mRNA; o,p'-DDT results in increased expression of C3 protein

PMID:10822019 PMID:11086226 PMID:11390168 PMID:24096037

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

Cdk5 and Abl enzyme substrate 1

increases expression

o,p'-DDT results in increased expression of CABLES1 mRNA

NCBI chr18:3,076,556...3,181,181
Ensembl chr18:3,075,524...3,181,181

G

capping actin protein, gelsolin like

increases expression

o,p'-DDT results in increased expression of CAPG mRNA

NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856

G

calpain 9

increases expression

o,p'-DDT results in increased expression of CAPN9 mRNA

NCBI chr19:52,549,448...52,586,413
Ensembl chr19:52,549,448...52,586,413

G

carbonic anhydrase 2

increases expression

o,p'-DDT results in increased expression of CAR2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 3

affects expression

o,p'-DDT affects the expression of CA3 mRNA

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

caspase recruitment domain family, member 10

decreases expression

o,p'-DDT analog results in decreased expression of CARD10 mRNA

NCBI chr 7:110,330,460...110,371,551
Ensembl chr 7:110,330,408...110,359,224

G

caspase recruitment domain family, member 6

decreases expression

o,p'-DDT analog results in decreased expression of CARD6 mRNA

NCBI chr 2:54,194,343...54,206,902
Ensembl chr 2:54,195,739...54,206,846

G

cysteinyl-tRNA synthetase 1

increases expression

o,p'-DDT results in increased expression of CARS1 mRNA

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

caspase 1

increases expression

o,p'-DDT analog results in increased expression of CASP1 mRNA

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 12

increases expression

o,p'-DDT results in increased expression of CASP12 mRNA

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 14

decreases expression

o,p'-DDT analog results in decreased expression of CASP14 mRNA

NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405

G

caspase 2

increases expression

o,p'-DDT analog results in increased expression of CASP2 mRNA; o,p'-DDT results in increased expression of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

increases expression
multiple interactions

o,p'-DDT analog results in increased expression of CASP3 protein; o,p'-DDT results in increased expression of CASP3 mRNA; o,p'-DDT results in increased expression of CASP3 protein
o,p'-DDT results in increased expression of CASP3 protein modified form
Quercetin inhibits the reaction [o,p'-DDT results in increased expression of CASP3 protein modified form]

PMID:22937105 PMID:35122929

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases expression

o,p'-DDT results in increased expression of CASP4 mRNA

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 6

decreases expression

o,p'-DDT analog results in decreased expression of CASP6 mRNA

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of CASP7 mRNA
o,p'-DDT results in increased expression of CASP7 mRNA

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of CASP8 mRNA
o,p'-DDT results in increased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 8 associated protein 2

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of CASP8AP2 mRNA; o,p'-DDT results in decreased expression of CASP8AP2 mRNA
o,p'-DDT analog results in increased expression of CASP8AP2 mRNA

NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275

G

caspase 9

decreases expression
increases expression
affects expression
multiple interactions

o,p'-DDT analog results in decreased expression of CASP9 mRNA
o,p'-DDT results in increased expression of CASP9 mRNA
o,p'-DDT affects the expression of CASP9 mRNA
Quercetin inhibits the reaction [o,p'-DDT results in increased expression of CASP9 protein modified form]

PMID:18925944 PMID:22937105 PMID:35122929

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity

Quercetin inhibits the reaction [o,p'-DDT results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

coiled-coil domain containing 85A

increases methylation

o,p'-DDT results in increased methylation of CCDC85A gene

NCBI chr14:102,126,574...102,359,207
Ensembl chr14:102,129,029...102,359,058

G

C-C motif chemokine ligand 2

decreases expression

o,p'-DDT results in decreased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin A1

increases expression

o,p'-DDT results in increased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin B1

affects expression

o,p'-DDT affects the expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

affects expression

o,p'-DDT affects the expression of CCNB2 mRNA

PMID:17984292 PMID:18925944

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

multiple interactions
increases expression
affects expression

fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of CCND1 mRNA]
o,p'-DDT affects the expression of CCND1 mRNA

PMID:17984292 PMID:18925944 PMID:20206645 PMID:33728745

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

decreases expression

o,p'-DDT results in decreased expression of CCND2 mRNA

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin E2

decreases expression

o,p'-DDT results in decreased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin G2

affects expression

o,p'-DDT affects the expression of CCNG2 mRNA

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

chaperonin containing TCP1 subunit 2

increases expression

o,p'-DDT results in increased expression of CCT2 mRNA

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

G

chaperonin containing TCP1 subunit 4

increases expression

o,p'-DDT results in increased expression of CCT4 mRNA

NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267

G

chaperonin containing TCP1 subunit 5

increases expression

o,p'-DDT results in increased expression of CCT5 mRNA

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

chaperonin containing TCP1 subunit 7

increases expression

o,p'-DDT results in increased expression of CCT7 mRNA

NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580

G

CD24 molecule

increases expression

o,p'-DDT results in increased expression of CD24A mRNA

NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662

G

CD34 molecule

decreases expression

o,p'-DDT results in decreased expression of CD34 mRNA

NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832

G

CD40 molecule

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of CD40 mRNA
o,p'-DDT results in increased expression of CD40 mRNA

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD40 ligand

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of CD40LG mRNA
o,p'-DDT results in increased expression of CD40LG mRNA

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

CD55 molecule (Cromer blood group)

increases expression

o,p'-DDT results in increased expression of CD55 mRNA

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

G

cell division cycle 25A

increases expression

o,p'-DDT results in increased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle associated 8

decreases expression

o,p'-DDT results in decreased expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

G

CUB domain containing protein 1

increases expression

o,p'-DDT results in increased expression of CDCP1 mRNA

NCBI chr 8:122,828,685...122,865,345
Ensembl chr 8:122,828,685...122,865,388

G

cadherin 1

decreases expression

o,p'-DDT results in decreased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase 1

increases expression

o,p'-DDT results in increased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 9

increases expression

o,p'-DDT results in increased expression of CDK9 mRNA

NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410

G

cyclin-dependent kinase inhibitor 1A

affects expression
decreases expression

o,p'-DDT affects the expression of CDKN1A mRNA
o,p'-DDT results in decreased expression of CDKN1A mRNA

PMID:18925944 PMID:23209616

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

carboxylesterase 2H

affects expression

o,p'-DDT affects the expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

complement factor B

increases expression

o,p'-DDT results in increased expression of CFB mRNA

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

CASP8 and FADD-like apoptosis regulator

decreases expression

o,p'-DDT analog results in decreased expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

ChaC glutathione specific gamma-glutamylcyclotransferase 2

increases expression

o,p'-DDT results in increased expression of CHAC2 mRNA

NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301

G

cholinergic receptor, muscarinic 1

increases expression

o,p'-DDT results in increased expression of CHRM1 mRNA; o,p'-DDT results in increased expression of CHRM1 protein

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 3

increases expression

o,p'-DDT results in increased expression of CHRM3 mRNA; o,p'-DDT results in increased expression of CHRM3 protein

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor nicotinic alpha 1 subunit

increases expression

o,p'-DDT results in increased expression of CHRNA1 mRNA; o,p'-DDT results in increased expression of CHRNA1 protein

NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840

G

cytokine induced apoptosis inhibitor 1

increases expression

o,p'-DDT results in increased expression of CIAPIN1 mRNA

NCBI chr19:10,179,963...10,195,511
Ensembl chr19:10,180,100...10,195,503

G

cell death-inducing DFFA-like effector a

decreases expression

o,p'-DDT analog results in decreased expression of CIDEA mRNA

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cell death-inducing DFFA-like effector b

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of CIDEB mRNA
o,p'-DDT results in increased expression of CIDEB mRNA

NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605

G

cold inducible RNA binding protein

decreases expression

o,p'-DDT results in decreased expression of CIRBP mRNA

NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818

G

clusterin

decreases expression

o,p'-DDT results in decreased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

cytochrome c oxidase subunit 5A

increases expression

o,p'-DDT results in increased expression of COX5A mRNA

NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781

G

cytochrome c oxidase subunit 6B1

increases expression

o,p'-DDT results in increased expression of COX6B1 mRNA

NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
Ensembl chr 2:85,875,109...85,884,001

G

copine 7

increases expression

o,p'-DDT results in increased expression of CPNE7 mRNA

NCBI chr19:51,164,316...51,182,676
Ensembl chr19:51,166,034...51,182,677

G

carboxypeptidase X (M14 family), member 1

increases expression

o,p'-DDT results in increased expression of CPXM1 mRNA

NCBI chr 3:117,588,532...117,595,330
Ensembl chr 3:117,588,532...117,595,330

G

CASP2 and RIPK1 domain containing adaptor with death domain

decreases expression

o,p'-DDT analog results in decreased expression of CRADD mRNA

NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907

G

cAMP responsive element binding protein 1

increases phosphorylation
increases activity
affects localization

o,p'-DDT results in increased phosphorylation of CREB1 protein
o,p'-DDT results in increased activity of CREB1 protein
o,p'-DDT affects the localization of CREB1 protein

PMID:18791200 PMID:20678559

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

CREB binding protein

multiple interactions
increases activity

o,p'-DDT promotes the reaction [MAP2K6 protein results in increased activity of CREBBP protein]; SB 203580 inhibits the reaction [o,p'-DDT results in increased activity of CREBBP protein]

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

crooked neck pre-mRNA splicing factor 1

increases expression

o,p'-DDT results in increased expression of CRNKL1 mRNA

NCBI chr 3:133,338,593...133,354,329
Ensembl chr 3:133,337,039...133,354,302
Ensembl chr 6:133,337,039...133,354,302

G

casein kinase 2 alpha 1

increases expression

o,p'-DDT results in increased expression of CSNK2A1 mRNA

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

catenin beta 1

decreases expression

o,p'-DDT results in decreased expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

increases expression

o,p'-DDT results in increased expression of CTSD mRNA

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

C-X3-C motif chemokine ligand 1

decreases expression

o,p'-DDT results in decreased expression of CX3CL1 mRNA

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

cytochrome b-245 alpha chain

increases expression
multiple interactions

o,p'-DDT results in increased expression of CYBA mRNA
Quercetin inhibits the reaction [o,p'-DDT results in increased expression of CYBA mRNA]

PMID:24096037 PMID:35122929

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome b-245 beta chain

increases expression
multiple interactions

o,p'-DDT results in increased expression of CYBB mRNA
Quercetin inhibits the reaction [o,p'-DDT results in increased expression of CYBB mRNA]

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome c, somatic

increases expression
multiple interactions

o,p'-DDT results in increased expression of CYCS mRNA
o,p'-DDT results in increased expression of CYCS protein
Quercetin inhibits the reaction [o,p'-DDT results in increased expression of CYCS protein]

PMID:24096037 PMID:35122929

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression

o,p'-DDT results in decreased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

affects expression

o,p'-DDT affects the expression of CYP17A1 mRNA

PMID:17984292 PMID:18925944

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
increases expression
decreases activity
decreases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 mRNA]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; [alpha-naphthoflavone results in decreased activity of CYP19A1 protein] which results in decreased susceptibility to o,p'-DDT; [Dichlorodiphenyl Dichloroethylene co-treated with o,p'-DDT] results in decreased activity of CYP19A1 protein; [o,p'-DDT co-treated with Atrazine] results in increased activity of CYP19A1 protein; [vinclozolin co-treated with o,p'-DDT] results in decreased activity of CYP19A1 protein; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 mRNA]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]
o,p'-DDT results in increased expression of CYP19A1 mRNA; o,p'-DDT results in increased expression of CYP19A1 protein
o,p'-DDT results in decreased activity of CYP19A1 protein
o,p'-DDT results in decreased expression of CYP19A1 mRNA

PMID:17599374 PMID:20678559 PMID:28263910

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

affects expression
multiple interactions
increases expression

o,p'-DDT affects the expression of CYP1A1 mRNA
o,p'-DDT inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; o,p'-DDT inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; o,p'-DDT promotes the reaction [AHR protein binds to CYP1A1 promoter]
o,p'-DDT results in increased expression of CYP1A1 mRNA

PMID:12176094 PMID:18925944 PMID:28263910

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects expression
increases expression

o,p'-DDT affects the expression of CYP1A2 mRNA
o,p'-DDT results in increased expression of CYP1A2 mRNA

PMID:18925944 PMID:21924250

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 2

affects expression

o,p'-DDT affects the expression of CYP2B13 mRNA
o,p'-DDT affects the expression of CYP2B2 mRNA

PMID:17984292 PMID:18925944

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions
affects expression

o,p'-DDT results in increased expression of CYP2B6 mRNA; o,p'-DDT results in increased expression of CYP2B6 protein
o,p'-DDT inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]
o,p'-DDT affects the expression of CYP2B10 mRNA

PMID:10037683 PMID:15548381 PMID:18925944 PMID:21924250

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily c, polypeptide 24

affects expression

o,p'-DDT affects the expression of CYP2C55 mRNA

NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects expression
increases expression
multiple interactions
increases activity

o,p'-DDT affects the expression of CYP3A2 mRNA
o,p'-DDT results in increased expression of CYP3A4 mRNA; o,p'-DDT results in increased expression of CYP3A4 protein
Dactinomycin inhibits the reaction [o,p'-DDT results in increased expression of CYP3A4 mRNA]
o,p'-DDT results in increased activity of CYP3A4 protein

PMID:15548381 PMID:15795092 PMID:17035600 PMID:17984292 PMID:21924250

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

affects expression

o,p'-DDT affects the expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 51

affects expression

o,p'-DDT affects the expression of CYP51 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

affects expression

o,p'-DDT affects the expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 7 subfamily B member 1

affects expression

o,p'-DDT affects the expression of CYP7B1 mRNA

NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698

G

death associated protein kinase 1

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of DAPK1 mRNA
o,p'-DDT results in increased expression of DAPK1 mRNA

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

decorin

decreases expression

o,p'-DDT results in decreased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

DExD-box helicase 39A

increases expression

o,p'-DDT results in increased expression of DDX39A mRNA

NCBI chr19:24,418,743...24,427,422
Ensembl chr19:24,418,114...24,426,954

G

desmin

increases expression

o,p'-DDT results in increased expression of DES mRNA

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

DNA fragmentation factor subunit alpha

increases expression

o,p'-DDT analog results in increased expression of DFFA mRNA; o,p'-DDT results in increased expression of DFFA mRNA

NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633

G

DNA fragmentation factor subunit beta

decreases expression

o,p'-DDT analog results in decreased expression of DFFB mRNA

NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628

G

7-dehydrocholesterol reductase

affects expression

o,p'-DDT affects the expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

dehydrogenase/reductase 3

increases expression

o,p'-DDT results in increased expression of DHRS3 mRNA

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

DnaJ heat shock protein family (Hsp40) member C2

affects expression

o,p'-DDT affects the expression of DNAJC2 mRNA

NCBI chr 4:13,270,239...13,297,438
Ensembl chr 4:13,270,191...13,297,431

G

delta/notch-like EGF repeat containing

increases expression

o,p'-DDT results in increased expression of DNER mRNA

NCBI chr 9:85,586,985...85,902,461
Ensembl chr 9:85,586,987...85,902,637

G

DNA methyltransferase 3 alpha

increases expression

o,p'-DDT results in increased expression of DNMT3A mRNA

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

destrin, actin depolymerizing factor

increases expression

o,p'-DDT results in increased expression of DSTN mRNA

NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379

G

dynein light chain LC8-type 1

increases expression

o,p'-DDT results in increased expression of DYNLL1 mRNA

NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741

G

E2F transcription factor 7

increases expression

o,p'-DDT results in increased expression of E2F7 mRNA

NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734

G

eukaryotic translation elongation factor 1 gamma

increases expression

o,p'-DDT results in increased expression of EEF1G mRNA

NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382

G

eukaryotic translation initiation factor 2B subunit delta

increases expression

o,p'-DDT results in increased expression of EIF2B4 mRNA

NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829

G

eukaryotic translation initiation factor 2 subunit beta

affects expression
increases expression

o,p'-DDT affects the expression of EIF2S2 mRNA
o,p'-DDT results in increased expression of EIF2S2 mRNA

PMID:17984292 PMID:24096037

NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432

G

eukaryotic translation initiation factor 3, subunit C

affects expression

o,p'-DDT affects the expression of EIF3C mRNA

NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493

G

eukaryotic translation initiation factor 3, subunit G

increases expression

o,p'-DDT results in increased expression of EIF3G mRNA

NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:19,429,643...19,433,808

G

eukaryotic translation initiation factor 4E binding protein 1

affects expression

o,p'-DDT affects the expression of EIF4EBP1 mRNA

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 5

increases expression

o,p'-DDT results in increased expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

ETS transcription factor ELK1

increases activity

o,p'-DDT results in increased activity of ELK1 protein

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

elongin B

increases expression

o,p'-DDT results in increased expression of ELOB mRNA

NCBI chr10:12,848,830...12,853,897
Ensembl chr10:12,848,827...12,853,635

G

epoxide hydrolase 1

affects expression

o,p'-DDT affects the expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

glutamyl-prolyl-tRNA synthetase 1

increases expression

o,p'-DDT results in increased expression of EPRS1 mRNA

NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966

G

erb-b2 receptor tyrosine kinase 2

increases activity

o,p'-DDT results in increased activity of ERBB2 protein

PMID:9443065 PMID:11222871

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

ERCC excision repair 3, TFIIH core complex helicase subunit

increases expression

o,p'-DDT results in increased expression of ERCC3 mRNA

NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329

G

epiregulin

decreases expression

o,p'-DDT results in decreased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

estrogen receptor 1

affects binding
decreases expression
increases expression
multiple interactions
increases activity

o,p'-DDT binds to ESR1 protein
o,p'-DDT results in decreased expression of ESR1 mRNA; o,p'-DDT results in decreased expression of ESR1 protein
o,p'-DDT results in increased expression of ESR1 mRNA
[o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR1 protein; o,p'-DDT inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
o,p'-DDT results in increased activity of ESR1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in decreased expression of ESR1 mRNA]; [Estradiol co-treated with Genistein co-treated with o,p'-DDT] affects the expression of ESR1 mRNA; [o,p'-DDT co-treated with Methoxychlor co-treated with Dieldrin] results in increased expression of ESR1 mRNA; Fulvestrant inhibits the reaction [o,p'-DDT results in decreased expression of ESR1 mRNA]; o,p'-DDT binds to and results in increased activity of ESR1 protein; o,p'-DDT inhibits the reaction [Estradiol binds to ESR1 protein]; o,p'-DDT promotes the reaction [Estradiol results in increased activity of ESR1 protein]

PMID:8930550 PMID:9751507 PMID:9860891 PMID:11086226 PMID:11162928 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
decreases expression
increases activity

o,p'-DDT binds to and results in increased activity of ESR2 protein
o,p'-DDT results in decreased expression of ESR2 mRNA
[o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR2 protein
o,p'-DDT results in increased activity of ESR2 protein
o,p'-DDT results in decreased expression of ESR2 mRNA; o,p'-DDT results in decreased expression of ESR2 protein

PMID:9751507 PMID:9860891 PMID:15064155 PMID:16626760 PMID:18700809 More...

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

ethanolamine kinase 2

increases expression

o,p'-DDT results in increased expression of ETNK2 mRNA

NCBI chr13:44,811,012...44,829,052
Ensembl chr13:44,811,015...44,829,037

G

Fas associated via death domain

decreases expression

o,p'-DDT analog results in decreased expression of FADD mRNA

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

fatty acid desaturase 2

decreases expression

o,p'-DDT results in decreased expression of FADS2 mRNA

NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789

G

Fas apoptotic inhibitory molecule

decreases expression

o,p'-DDT analog results in decreased expression of FAIM mRNA; o,p'-DDT results in decreased expression of FAIM mRNA

NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562

G

family with sequence similarity 107, member A

decreases expression

o,p'-DDT results in decreased expression of FAM107A mRNA

NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396

G

Fas cell surface death receptor

affects expression
decreases expression
increases expression

o,p'-DDT affects the expression of FAS mRNA
o,p'-DDT analog results in decreased expression of FAS mRNA
o,p'-DDT results in increased expression of FAS mRNA

PMID:18925944 PMID:22937105

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression
decreases expression

o,p'-DDT results in increased expression of FASLG mRNA
o,p'-DDT analog results in decreased expression of FASLG mRNA

PMID:22609851 PMID:22937105

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibrillin 2

increases expression

o,p'-DDT results in increased expression of FBN2 mRNA

NCBI chr18:51,499,670...51,703,976
Ensembl chr18:51,499,737...51,703,976

G

folate receptor alpha

decreases expression

o,p'-DDT results in decreased expression of FOLR1 mRNA

NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions
affects localization

o,p'-DDT results in increased expression of FOS mRNA
o,p'-DDT results in increased expression of and results in increased activity of FOS protein
o,p'-DDT affects the localization of FOS protein

PMID:18840457 PMID:24096037 PMID:34167450

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

increases expression

o,p'-DDT results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box D1

increases expression

o,p'-DDT results in increased expression of FOXD1 mRNA

NCBI chr 2:29,702,558...29,704,978
Ensembl chr 2:29,702,558...29,704,978

G

follicle stimulating hormone subunit beta

multiple interactions

o,p'-DDT promotes the reaction [[FSHB protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

follicle stimulating hormone receptor

multiple interactions

o,p'-DDT promotes the reaction [[FSHB protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

ferritin light chain 1

affects expression

o,p'-DDT affects the expression of FTL1 mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725

G

FXYD domain-containing ion transport regulator 4

decreases expression

o,p'-DDT results in decreased expression of FXYD4 mRNA

NCBI chr 4:151,109,779...151,113,659
Ensembl chr 4:151,109,779...151,113,637

G

G0/G1switch 2

increases expression

o,p'-DDT results in increased expression of G0S2 mRNA

PMID:19371625 PMID:24096037

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

growth arrest and DNA-damage-inducible, alpha

affects expression
increases expression

o,p'-DDT affects the expression of GADD45A mRNA
o,p'-DDT analog results in increased expression of GADD45A mRNA; o,p'-DDT results in increased expression of GADD45A mRNA

PMID:18925944 PMID:22937105

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest and DNA-damage-inducible, beta

affects expression

o,p'-DDT affects the expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

polypeptide N-acetylgalactosaminyltransferase 4

increases expression

o,p'-DDT results in increased expression of GALNT4 mRNA

NCBI chr 7:33,925,229...33,927,770

G

galanin receptor 2

decreases expression

o,p'-DDT results in decreased expression of GALR2 mRNA

NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176

G

glutamate-cysteine ligase, catalytic subunit

affects expression

o,p'-DDT affects the expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

affects expression

o,p'-DDT affects the expression of GCLM mRNA

PMID:17984292 PMID:18925944

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glycerophosphodiester phosphodiesterase domain containing 5

increases expression

o,p'-DDT results in increased expression of GDPD5 mRNA

NCBI chr 1:153,679,718...153,761,452
Ensembl chr 1:153,679,718...153,761,446

G

gonadotropin releasing hormone 1

multiple interactions
affects secretion

o,p'-DDT affects the reaction [LHB protein results in increased susceptibility to GNRH1 protein]
o,p'-DDT affects the secretion of GNRH1 protein

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

G protein-coupled receptor 142

increases expression

o,p'-DDT results in increased expression of GPR142 mRNA

NCBI chr10:99,840,069...99,843,410
Ensembl chr10:99,840,069...99,843,410

G

glutathione peroxidase 2

affects expression

o,p'-DDT affects the expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

GRAM domain containing 2B

decreases expression

o,p'-DDT results in decreased expression of GRAMD2B mRNA

NCBI chr18:49,884,014...49,981,955
Ensembl chr18:49,884,014...49,981,953

G

gremlin 1, DAN family BMP antagonist

increases expression

o,p'-DDT results in increased expression of GREM1 mRNA

NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082

G

G1 to S phase transition 1

increases expression

o,p'-DDT results in increased expression of GSPT1 mRNA

NCBI chr10:4,362,528...4,397,215
Ensembl chr10:4,362,510...4,397,198

G

glutathione-disulfide reductase

affects expression

o,p'-DDT affects the expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 2

affects expression

o,p'-DDT affects the expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 3

affects expression

o,p'-DDT affects the expression of GSTA3 mRNA

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase mu 2

affects expression

o,p'-DDT affects the expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase theta 1

affects expression

o,p'-DDT affects the expression of GSTT1 mRNA

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

granzyme A

increases expression

o,p'-DDT results in increased expression of GZMA mRNA

NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493

G

hyaluronan and proteoglycan link protein 3

decreases expression

o,p'-DDT results in decreased expression of HAPLN3 mRNA

NCBI chr 1:133,046,465...133,064,665
Ensembl chr 1:133,046,467...133,080,177

G

hes family bHLH transcription factor 2

increases expression

o,p'-DDT results in increased expression of HES2 mRNA

NCBI chr 5:162,667,190...162,668,235
Ensembl chr 5:162,667,190...162,668,235

G

histone cluster 1 H2B family member D

decreases expression

o,p'-DDT results in decreased expression of H2BC5 mRNA

NCBI chr17:42,792,887...42,793,268

G

HIVEP zinc finger 1

increases expression

o,p'-DDT results in increased expression of HIVEP1 mRNA

NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,585,016...22,711,956

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

o,p'-DDT results in decreased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

high mobility group nucleosomal binding domain 2

decreases expression

o,p'-DDT results in decreased expression of HMGN2 mRNA

NCBI chr 5:146,192,126...146,195,580
Ensembl chr 5:146,192,126...146,195,521
Ensembl chr16:146,192,126...146,195,521

G

heme oxygenase 1

affects expression

o,p'-DDT affects the expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heme oxygenase 2

affects expression

o,p'-DDT affects the expression of HMOX2 mRNA

NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148

G

heterogeneous nuclear ribonucleoprotein A/B

increases expression

o,p'-DDT results in increased expression of HNRNPAB mRNA

NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344

G

heterogeneous nuclear ribonucleoprotein U

increases expression

o,p'-DDT results in increased expression of HNRNPU mRNA

NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588

G

harakiri, BCL2 interacting protein

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of HRK mRNA
o,p'-DDT results in increased expression of HRK mRNA

PMID:18204070 PMID:22937105

NCBI chr12:38,387,484...38,409,652

G

heat shock protein 90 alpha family class A member 1

increases expression
affects expression

o,p'-DDT results in increased expression of HSP90AA1 mRNA
o,p'-DDT affects the expression of HSP90AA1 mRNA

PMID:17984292 PMID:24096037

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

affects expression

o,p'-DDT affects the expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 2

decreases expression

o,p'-DDT results in decreased expression of HSPA2 mRNA

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 4

increases expression

o,p'-DDT results in increased expression of HSPA4 mRNA
o,p'-DDT analog results in increased expression of HSPA4 mRNA; o,p'-DDT results in increased expression of HSPA4 mRNA

PMID:22937105 PMID:24096037

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 8

increases expression

o,p'-DDT results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family D (Hsp60) member 1

increases expression
affects expression

o,p'-DDT results in increased expression of HSPD1 mRNA
o,p'-DDT affects the expression of HSPD1 mRNA

PMID:17984292 PMID:24096037

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

affects expression

o,p'-DDT affects the expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

heat shock protein family H (Hsp110) member 1

increases expression

o,p'-DDT results in increased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

o,p'-DDT results in decreased expression of IDI1 mRNA

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

insulin-like growth factor 1

affects expression
increases expression

o,p'-DDT affects the expression of IGF1 mRNA
o,p'-DDT results in increased expression of IGF1 mRNA

PMID:17984292 PMID:24096037

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 3

affects expression

o,p'-DDT affects the expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

interleukin 10

decreases expression

o,p'-DDT analog results in decreased expression of IL10 mRNA

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions
increases expression

[DDT co-treated with o,p'-DDT] results in decreased expression of IL1B mRNA
o,p'-DDT results in increased expression of IL1B

PMID:12007859 PMID:15104118

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 24

increases expression

o,p'-DDT results in increased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 6

increases expression

o,p'-DDT results in increased expression of IL6; o,p'-DDT results in increased expression of IL6 mRNA

PMID:15104118 PMID:17035600

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

increases expression

o,p'-DDT results in increased expression of IL6R mRNA

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

inosine monophosphate dehydrogenase 2

increases expression

o,p'-DDT results in increased expression of IMPDH2 mRNA

NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359

G

insulin induced gene 2

affects expression

o,p'-DDT affects the expression of INSIG2 mRNA

NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923

G

interferon regulatory factor 1

affects expression

o,p'-DDT affects the expression of IRF1 mRNA

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

integrin subunit alpha 6

increases expression

o,p'-DDT results in increased expression of ITGA6 mRNA

NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions
affects localization

o,p'-DDT results in increased expression of JUN mRNA
o,p'-DDT results in increased expression of and results in increased activity of JUN protein
o,p'-DDT affects the localization of JUN protein

PMID:18840457 PMID:24096037 PMID:34167450

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily A member 3

multiple interactions
decreases activity

[o,p'-DDT results in decreased activity of KCNA3 protein] which results in decreased import of Thallium

NCBI chr 2:194,632,106...194,634,059
Ensembl chr 2:194,632,196...194,650,138

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

[o,p'-DDT results in decreased activity of KCNH2 protein] which results in decreased import of Thallium

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium channel tetramerization domain containing 20

increases expression

o,p'-DDT results in increased expression of KCTD20 mRNA

NCBI chr20:7,015,828...7,032,766
Ensembl chr20:7,015,833...7,032,761

G

kinesin family member 20A

decreases expression

o,p'-DDT results in decreased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

KLF transcription factor 4

increases expression

o,p'-DDT results in increased expression of KLF4 mRNA

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

keratin 13

increases expression

o,p'-DDT results in increased expression of KRT13 mRNA

NCBI chr10:85,051,887...85,056,099
Ensembl chr10:85,051,889...85,056,084

G

keratin 17

decreases expression

o,p'-DDT results in decreased expression of KRT17 mRNA

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392

G

keratin 8

increases expression

o,p'-DDT results in increased expression of KRT8 mRNA

NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728

G

La ribonucleoprotein 6, translational regulator

increases expression

o,p'-DDT results in increased expression of LARP6 mRNA

NCBI chr 8:61,183,744...61,205,548
Ensembl chr 8:61,184,116...61,205,535

G

low density lipoprotein receptor

decreases expression

o,p'-DDT results in decreased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

luteinizing hormone subunit beta

multiple interactions

o,p'-DDT affects the reaction [LHB protein results in increased susceptibility to GNRH1 protein]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

LIM homeobox 4

decreases expression

o,p'-DDT analog results in decreased expression of LHX4 mRNA

NCBI chr13:67,877,109...67,917,219
Ensembl chr13:67,877,109...67,927,003

G

lipase G, endothelial type

decreases expression

o,p'-DDT results in decreased expression of LIPG mRNA

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

G

lamin A/C

increases expression

o,p'-DDT results in increased expression of LMNA mRNA

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

leucine rich repeat containing 17

decreases expression

o,p'-DDT results in decreased expression of LRRC17 mRNA

NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845

G

lymphotoxin alpha

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of LTA mRNA
o,p'-DDT results in increased expression of LTA mRNA

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

lymphotoxin beta receptor

increases expression
decreases expression

o,p'-DDT results in increased expression of LTBR mRNA
o,p'-DDT analog results in decreased expression of LTBR mRNA

NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539

G

lactotransferrin

multiple interactions
increases expression

fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of LTF mRNA]
o,p'-DDT results in increased expression of LTF mRNA; o,p'-DDT results in increased expression of LTF protein

PMID:9607801 PMID:11390168

NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795

G

latexin

decreases expression

o,p'-DDT results in decreased expression of LXN mRNA

NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460

G

LYL1, basic helix-loop-helix family member

increases expression

o,p'-DDT results in increased expression of LYL1 mRNA

NCBI chr19:23,452,140...23,455,007
Ensembl chr19:23,452,140...23,455,007

G

lysosomal trafficking regulator

increases expression

o,p'-DDT results in increased expression of LYST mRNA

NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480

G

MAF bZIP transcription factor B

increases expression

o,p'-DDT results in increased expression of MAFB mRNA

NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031

G

MAGE family member D1

increases expression

o,p'-DDT results in increased expression of MAGED1 mRNA

NCBI chr X:59,422,715...59,429,381
Ensembl chr X:59,422,717...59,429,364

G

MAK16 homolog

increases expression

o,p'-DDT results in increased expression of RBM13 mRNA

NCBI chr16:60,972,699...60,981,250
Ensembl chr16:60,972,697...60,983,243

G

MANSC domain containing 1

decreases expression

o,p'-DDT results in decreased expression of MANSC1 mRNA

NCBI chr 4:167,438,817...167,459,047
Ensembl chr 4:167,439,071...167,479,606

G

mitogen-activated protein kinase kinase 6

multiple interactions

o,p'-DDT promotes the reaction [MAP2K6 protein results in increased activity of CREBBP protein]

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions
increases activity

o,p'-DDT results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK1 protein]; MAPK1 protein promotes the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK1 protein]; o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK1 protein
o,p'-DDT results in increased activity of MAPK1 protein

PMID:11222871 PMID:12523960 PMID:18791200 PMID:18840457 PMID:20678559 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 13

decreases expression

o,p'-DDT results in decreased expression of MAPK13 mRNA

NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222

G

mitogen activated protein kinase 14

multiple interactions

MAPK14 protein promotes the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK3 protein]; o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK3 protein]

PMID:11222871 PMID:18840457 PMID:20678559 PMID:34167450

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK8 protein; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK8 protein]
o,p'-DDT results in increased phosphorylation of MAPK8 protein
pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK8 protein]

PMID:18840457 PMID:20678559

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 8 interacting protein 1

increases expression

o,p'-DDT analog results in increased expression of MAPK8IP1 mRNA; o,p'-DDT results in increased expression of MAPK8IP1 mRNA

NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of MAPK9 protein]
o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK9 protein; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased phosphorylation of and results in increased activity of MAPK9 protein]

PMID:18840457 PMID:20678559

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MCL1 apoptosis regulator, BCL2 family member

increases expression
decreases expression

o,p'-DDT results in increased expression of MCL1 mRNA
o,p'-DDT analog results in decreased expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

MDM2 proto-oncogene

affects expression

o,p'-DDT affects the expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

mesenchyme homeobox 1

decreases expression

o,p'-DDT results in decreased expression of MEOX1 mRNA

NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

o,p'-DDT results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

milk fat globule EGF and factor V/VIII domain containing

decreases expression

o,p'-DDT results in decreased expression of MFGE8 mRNA

NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073

G

mitofusin 2

increases expression

o,p'-DDT results in increased expression of MFN2 mRNA

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

melanophilin

increases expression

o,p'-DDT results in increased expression of MLPH mRNA

NCBI chr 9:91,507,410...91,542,984
Ensembl chr 9:91,507,591...91,542,983

G

matrix metallopeptidase 2

increases expression

o,p'-DDT results in increased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 23

increases expression

o,p'-DDT results in increased expression of MMP23 mRNA

NCBI chr 5:166,239,643...166,242,734
Ensembl chr 5:166,239,644...166,242,433

G

matrix metallopeptidase 9

increases expression

o,p'-DDT results in increased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mitochondrial ribosomal protein S7

increases expression

o,p'-DDT results in increased expression of MRPS7 mRNA

NCBI chr10:100,843,691...100,846,838
Ensembl chr10:100,843,356...100,847,129

G

mucin 5AC, oligomeric mucus/gel-forming

increases expression
multiple interactions

o,p'-DDT results in increased expression of MUC5AC mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]; Curcumin inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]; SB 203580 inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

myc target 1

increases expression

o,p'-DDT results in increased expression of MYCT1 mRNA

NCBI chr 1:42,018,137...42,029,410
Ensembl chr 1:42,018,137...42,029,410

G

myosin heavy chain 6

increases expression

o,p'-DDT results in increased expression of MYH6 mRNA

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin VA

increases expression

o,p'-DDT results in increased expression of MYO5A mRNA

NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918

G

myosin Vb

increases expression

o,p'-DDT results in increased expression of MYO5B mRNA

NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745

G

NLR family, apoptosis inhibitory protein 6

increases expression

o,p'-DDT analog results in increased expression of NAIP2 mRNA

NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542

G

neutrophil cytosolic factor 1

increases expression
multiple interactions

o,p'-DDT results in increased expression of NCF1 mRNA
Quercetin inhibits the reaction [o,p'-DDT results in increased expression of NCF1 mRNA]

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

neutrophil cytosolic factor 2

multiple interactions
increases expression

Quercetin inhibits the reaction [o,p'-DDT results in increased expression of NCF2 mRNA]

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

G

neutrophil cytosolic factor 4

multiple interactions
increases expression

Quercetin inhibits the reaction [o,p'-DDT results in increased expression of NCF4 mRNA]

NCBI chr 7:109,825,420...109,843,389
Ensembl chr 7:109,826,020...109,843,389

G

nuclear receptor coactivator 1

multiple interactions

o,p'-DDT promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

NADH:ubiquinone oxidoreductase subunit A1

increases expression

o,p'-DDT results in increased expression of NDUFA1 mRNA

NCBI chr X:116,424,223...116,427,875
Ensembl chr X:116,424,223...116,428,633

G

NADH:ubiquinone oxidoreductase subunit S5

increases expression

o,p'-DDT results in increased expression of NDUFS5 mRNA

NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603
Ensembl chr14:135,974,034...135,979,603
Ensembl chr 2:135,974,034...135,979,603

G

NADH:ubiquinone oxidoreductase core subunit V2

increases expression

o,p'-DDT results in increased expression of NDUFV2 mRNA

NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713

G

nei-like DNA glycosylase 2

increases expression

o,p'-DDT results in increased expression of NEIL2 mRNA

NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863

G

nuclear factor kappa B subunit 1

increases expression

o,p'-DDT analog results in increased expression of NFKB1 mRNA; o,p'-DDT results in increased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

niban apoptosis regulator 1

increases expression

o,p'-DDT results in increased expression of NIBAN1 mRNA

NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

o,p'-DDT results in increased expression of NME1 mRNA

NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408

G

nucleolar protein 3

increases expression

o,p'-DDT analog results in increased expression of NOL3 mRNA; o,p'-DDT results in increased expression of NOL3 mRNA

NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250

G

nitric oxide synthase 2

multiple interactions
increases expression

[DDT co-treated with o,p'-DDT] results in decreased expression of NOS2 mRNA
o,p'-DDT results in increased expression of NOS2

PMID:12007859 PMID:15104118

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

multiple interactions

MAPK1 protein promotes the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]; MAPK14 protein promotes the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]; o,p'-DDT results in increased phosphorylation of and results in increased activity of NOTCH1 protein; SB 203580 inhibits the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]; U 0126 inhibits the reaction [o,p'-DDT results in increased activity of NOTCH1 protein]

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

NADPH oxidase 1

multiple interactions
increases expression

Quercetin inhibits the reaction [o,p'-DDT results in increased expression of NOX1 mRNA]

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

NPC intracellular cholesterol transporter 1

increases expression

o,p'-DDT results in increased expression of NPC1 mRNA

NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049

G

NAD(P)H quinone dehydrogenase 1

affects expression

o,p'-DDT affects the expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
affects expression
increases activity

o,p'-DDT binds to and results in increased activity of NR1I2 protein
o,p'-DDT affects the expression of NR1I2 mRNA
o,p'-DDT results in increased activity of NR1I2 protein

PMID:15548381 PMID:16054614 PMID:17984292 PMID:18925944 PMID:21115097 More...

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

affects expression
multiple interactions
increases activity

o,p'-DDT affects the expression of NR1I3 mRNA
o,p'-DDT inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]; o,p'-DDT promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
o,p'-DDT results in increased activity of NR1I3 protein

PMID:10037683 PMID:17984292 PMID:18925944 PMID:21924250 PMID:26187274 More...

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

o,p'-DDT inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions

o,p'-DDT inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; o,p'-DDT inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

out at first homolog

increases expression

o,p'-DDT results in increased expression of OAF mRNA

NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334

G

olfactomedin 1

increases expression

o,p'-DDT results in increased expression of OLFM1 mRNA

NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239

G

olfactomedin-like 3

increases expression

o,p'-DDT results in increased expression of OLFML3 mRNA

NCBI chr 2:191,244,221...191,247,050
Ensembl chr 2:191,244,221...191,247,050

G

oxysterol binding protein-like 1A

affects expression

o,p'-DDT affects the expression of OSBPL1A mRNA

NCBI chr18:3,904,006...4,094,635
Ensembl chr18:3,904,006...4,094,585

G

osteoclast associated Ig-like receptor

increases expression

o,p'-DDT results in increased expression of OSCAR mRNA

NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758

G

poly(A) binding protein, cytoplasmic 1

increases expression

o,p'-DDT results in increased expression of PABPC1 mRNA

NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744

G

poly (ADP-ribose) polymerase 1

affects expression

o,p'-DDT affects the expression of PARP1 mRNA

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

o,p'-DDT inhibits the reaction [Hydrocortisone results in increased expression of PCK1 mRNA]

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

programmed cell death 2

increases expression

o,p'-DDT results in increased expression of PDCD2 mRNA

NCBI chr 1:56,484,947...56,490,437
Ensembl chr 1:56,463,931...56,490,437

G

programmed cell death 5

increases expression

o,p'-DDT results in increased expression of PDCD5 mRNA

NCBI chr 1:88,305,869...88,311,200
Ensembl chr 1:88,305,869...88,311,200

G

programmed cell death 7

increases expression

o,p'-DDT results in increased expression of PDCD7 mRNA

NCBI chr 8:65,862,606...65,877,333
Ensembl chr 8:65,862,387...65,877,333

G

pellino E3 ubiquitin protein ligase 1

decreases expression

o,p'-DDT results in decreased expression of PELI1 mRNA

NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285

G

progesterone receptor

multiple interactions
affects binding
increases expression
decreases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of PGR mRNA]; o,p'-DDT inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; o,p'-DDT inhibits the reaction [Progesterone binds to PGR protein]; o,p'-DDT inhibits the reaction [Progesterone results in increased expression of PGR protein]
o,p'-DDT binds to PGR protein
o,p'-DDT results in decreased expression of PGR mRNA
o,p'-DDT promotes the reaction [Progesterone binds to PGR protein]

PMID:7414049 PMID:9607801 PMID:10822019 PMID:11867264 PMID:14579009 More...

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phosphatidylinositol 4-kinase alpha

increases activity

o,p'-DDT results in increased activity of PI4KA protein

NCBI chr11:83,609,148...83,726,876
Ensembl chr11:83,609,069...83,724,080

G

protein inhibitor of activated STAT, 2

increases expression

o,p'-DDT results in increased expression of PIAS2 mRNA

NCBI chr18:70,608,034...70,714,295
Ensembl chr18:70,607,665...70,710,033

G

Pim-1 proto-oncogene, serine/threonine kinase

increases expression

o,p'-DDT results in increased expression of PIM1 mRNA

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

pyruvate kinase M1/2

increases expression

o,p'-DDT results in increased expression of PKM mRNA

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

phospholipase A2, group III

decreases expression

o,p'-DDT results in decreased expression of PLA2G3 mRNA

NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913

G

phospholipid phosphatase related 2

increases expression

o,p'-DDT results in increased expression of PLPPR2 mRNA

NCBI chr 8:20,467,071...20,479,474
Ensembl chr 8:20,467,071...20,479,474

G

DNA polymerase beta

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of POLB mRNA
o,p'-DDT results in increased expression of POLB mRNA

NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812

G

cytochrome p450 oxidoreductase

affects expression

o,p'-DDT affects the expression of POR mRNA

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

peroxiredoxin 2

decreases expression

o,p'-DDT analog results in decreased expression of PRDX2 mRNA; o,p'-DDT results in decreased expression of PRDX2 mRNA

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

protein kinase cAMP-activated catalytic subunit alpha

increases activity
decreases activity

o,p'-DDT results in increased activity of PRKACA protein
o,p'-DDT results in decreased activity of PRKACA protein

PMID:19526567 PMID:23209616

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

G

protein kinase cAMP-dependent type II regulatory subunit alpha

increases expression

o,p'-DDT results in increased expression of PRKAR2A mRNA

NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628

G

prolactin

multiple interactions
increases secretion
increases expression

Nifedipine inhibits the reaction [o,p'-DDT results in increased secretion of PRL protein]
ICI 164384 inhibits the reaction [o,p'-DDT results in increased expression of PRL mRNA]

PMID:8968093 PMID:15811834

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prolactin receptor

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of PRLR mRNA
o,p'-DDT results in increased expression of PRLR mRNA
o,p'-DDT results in decreased expression of PRLR mRNA

PMID:22937105 PMID:33728745

NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718

G

prokineticin 2

decreases expression

o,p'-DDT analog results in decreased expression of PROK2 mRNA

NCBI chr 4:132,346,681...132,361,754
Ensembl chr 4:132,347,103...132,361,385

G

pre-mRNA processing factor 8

increases expression

o,p'-DDT results in increased expression of PRPF8 mRNA

NCBI chr10:60,331,494...60,354,606
Ensembl chr10:60,331,494...60,354,606

G

proteasome 20S subunit alpha 4

increases expression
affects expression

o,p'-DDT results in increased expression of PSMA4 mRNA
o,p'-DDT affects the expression of PSMA4 mRNA

PMID:17984292 PMID:24096037

NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890

G

proteasome 20S subunit alpha 5

affects expression

o,p'-DDT affects the expression of PSMA5 mRNA

NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731

G

proteasome 20S subunit alpha 6

affects expression

o,p'-DDT affects the expression of PSMA6 mRNA

NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554

G

proteasome 20S subunit beta 1

affects expression
increases expression

o,p'-DDT affects the expression of PSMB1 mRNA
o,p'-DDT results in increased expression of PSMB1 mRNA

PMID:17984292 PMID:24096037

NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560

G

proteasome 20S subunit beta 4

affects expression

o,p'-DDT affects the expression of PSMB4 mRNA

NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746

G

proteasome 20S subunit beta 5

increases expression
affects expression

o,p'-DDT results in increased expression of PSMB5 mRNA
o,p'-DDT affects the expression of PSMB5 mRNA

PMID:17984292 PMID:24096037

NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440

G

proteasome 26S subunit, ATPase 3

affects expression

o,p'-DDT affects the expression of PSMC3 mRNA

NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358

G

proteasome 26S subunit, ATPase 4

affects expression

o,p'-DDT affects the expression of PSMC4 mRNA

NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494

G

proteasome 26S subunit, ATPase 5

increases expression

o,p'-DDT results in increased expression of PSMC5 mRNA

NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135

G

proteasome 26S subunit, non-ATPase 1

affects expression

o,p'-DDT affects the expression of PSMD1 mRNA

NCBI chr 9:86,709,714...86,785,213
Ensembl chr 9:86,709,947...86,785,211

G

proteasome 26S subunit, non-ATPase 12

affects expression

o,p'-DDT affects the expression of PSMD12 mRNA

NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 2

increases expression
affects expression

o,p'-DDT results in increased expression of PSMD2 mRNA
o,p'-DDT affects the expression of PSMD2 mRNA

PMID:17984292 PMID:24096037

NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 4

affects expression

o,p'-DDT affects the expression of PSMD4 mRNA

NCBI chr 2:182,598,934...182,608,250
Ensembl chr 2:182,598,934...182,608,194

G

proteasome 26S subunit, non-ATPase 8

affects expression

o,p'-DDT affects the expression of PSMD8 mRNA

NCBI chr 1:84,474,377...84,481,209
Ensembl chr 1:84,474,378...84,481,209

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression
decreases expression

6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased susceptibility to o,p'-DDT; [o,p'-DDT results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]
o,p'-DDT results in increased expression of PTGS2 mRNA; o,p'-DDT results in increased expression of PTGS2 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; [o,p'-DDT results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; pyrazolanthrone inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]
o,p'-DDT results in decreased expression of PTGS2 mRNA
[o,p'-DDT results in decreased expression of PTGS2 mRNA] which results in decreased abundance of Dinoprostone

PMID:18840457 PMID:20678559 PMID:23209616

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, receptor type, C

increases expression

o,p'-DDT results in increased expression of PTPRC mRNA

NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692

G

PYD and CARD domain containing

decreases expression

o,p'-DDT analog results in decreased expression of PYCARD mRNA

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

RAB3A interacting protein-like 1

increases expression

o,p'-DDT results in increased expression of RAB3IL1 mRNA

NCBI chr 1:206,646,168...206,682,718
Ensembl chr 1:206,646,155...206,679,972

G

RAN, member RAS oncogene family

affects expression

o,p'-DDT affects the expression of RAN mRNA

NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276

G

RNA binding protein, mRNA processing factor

decreases expression

o,p'-DDT results in decreased expression of RBPMS mRNA

NCBI chr16:58,239,370...58,395,424
Ensembl chr16:58,239,474...58,395,426

G

RecQ like helicase 4

increases methylation

o,p'-DDT results in increased methylation of RECQL4 gene

NCBI chr 7:108,423,453...108,430,790
Ensembl chr 7:108,423,455...108,430,619

G

RELA proto-oncogene, NF-kB subunit

affects localization

o,p'-DDT affects the localization of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

arginine-glutamic acid dipeptide repeats

decreases expression

o,p'-DDT results in decreased expression of RERE mRNA

NCBI chr 5:160,765,855...161,097,678
Ensembl chr 5:160,765,934...161,097,677

G

similar to RIKEN cDNA 3110043O21

increases expression

o,p'-DDT results in increased expression of C9ORF72 mRNA

NCBI chr 5:49,766,340...49,791,434
Ensembl chr 5:49,766,325...49,791,408

G

receptor-interacting serine-threonine kinase 2

increases expression
decreases expression

o,p'-DDT results in increased expression of RIPK2 mRNA
o,p'-DDT analog results in decreased expression of RIPK2 mRNA

NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657

G

RecQ mediated genome instability 2

decreases expression

o,p'-DDT results in decreased expression of RMI2 mRNA

NCBI chr10:4,829,333...4,837,264
Ensembl chr10:4,830,553...4,837,235

G

ribosomal protein L13

affects expression

o,p'-DDT affects the expression of RPL13 mRNA

NCBI chr19:51,153,990...51,156,541
Ensembl chr19:51,153,924...51,163,014

G

ribosomal protein L18

affects expression

o,p'-DDT affects the expression of RPL18 mRNA

NCBI chr 1:96,188,811...96,191,452
Ensembl chr 1:96,188,112...96,191,452

G

ribosomal protein L23

affects expression

o,p'-DDT affects the expression of RPL23 mRNA

NCBI chr10:82,771,878...82,775,840
Ensembl chr10:82,771,538...82,775,870

G

ribosomal protein L3

affects expression

o,p'-DDT affects the expression of RPL3 mRNA

NCBI chr 7:111,622,255...111,627,640
Ensembl chr 7:111,621,610...111,636,468

G

ribosomal protein L37

affects expression

o,p'-DDT affects the expression of RPL37 mRNA

NCBI chr 2:54,215,469...54,217,429
Ensembl chr 2:54,215,469...54,217,442

G

ribosomal protein L6

affects expression

o,p'-DDT affects the expression of RPL6 mRNA

NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921

G

ribosomal protein S15a

affects expression

o,p'-DDT affects the expression of RPS15A mRNA

NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995

G

ribosomal protein S17

affects expression

o,p'-DDT affects the expression of RPS17 mRNA

NCBI chr 1:135,295,920...135,298,506
Ensembl chr 1:135,295,919...135,298,535
Ensembl chr 8:135,295,919...135,298,535

G

ribosomal protein S20

affects expression

o,p'-DDT affects the expression of RPS20 mRNA

NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475

G

ribosomal protein S3

affects expression

o,p'-DDT affects the expression of RPS3 mRNA

NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680

G

ribosomal protein S5

affects expression

o,p'-DDT affects the expression of RPS5 mRNA

NCBI chr 1:73,538,776...73,543,073
Ensembl chr 1:73,538,776...73,543,073

G

ribosomal protein S6

affects expression

o,p'-DDT affects the expression of RPS6 mRNA

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S8

affects expression

o,p'-DDT affects the expression of RPS8 mRNA

NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268

G

ribosomal protein SA

affects expression

o,p'-DDT affects the expression of RPSA mRNA

NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247

G

ribonucleotide reductase regulatory subunit M2

decreases expression

o,p'-DDT results in decreased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

RUNX family transcription factor 1

decreases expression

o,p'-DDT results in decreased expression of RUNX1 mRNA

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

sphingosine-1-phosphate receptor 3

increases expression

o,p'-DDT results in increased expression of S1PR3 mRNA

NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505

G

Sin3A associated protein 18

increases expression

o,p'-DDT results in increased expression of SAP18 mRNA

NCBI chr15:31,943,228...31,947,534
Ensembl chr15:31,943,230...31,950,038
Ensembl chr10:31,943,230...31,950,038

G

secretoglobin, family 1D, member 2

increases expression

o,p'-DDT results in increased expression of SCGB1D2 mRNA

NCBI chr 1:206,228,546...206,233,587
Ensembl chr 1:206,228,778...206,231,785

G

serpin family A member 3N

increases expression

o,p'-DDT results in increased expression of SERPINA3 mRNA

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family B member 5

increases expression

o,p'-DDT results in increased expression of SERPINB5 mRNA

NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756

G

SERTA domain containing 2

increases expression

o,p'-DDT results in increased expression of SERTAD2 mRNA

NCBI chr14:94,733,637...94,838,200
Ensembl chr14:94,733,579...94,838,313

G

sestrin 2

increases expression

o,p'-DDT results in increased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

splicing factor 1

increases expression

o,p'-DDT results in increased expression of SF1 mRNA

NCBI chr 1:203,670,016...203,683,432
Ensembl chr 1:203,670,018...203,684,330

G

splicing factor 3b, subunit 3

increases expression

o,p'-DDT results in increased expression of SF3B3 mRNA

NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245

G

splicing factor 3b, subunit 5

increases expression

o,p'-DDT results in increased expression of SF3B5 mRNA

NCBI chr 1:7,357,040...7,357,752
Ensembl chr 1:7,350,731...7,357,839

G

splicing factor proline and glutamine rich

increases expression

o,p'-DDT results in increased expression of SFPQ mRNA

NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472

G

shugoshin 2

decreases expression

o,p'-DDT results in decreased expression of SGO2 mRNA

NCBI chr 9:59,548,605...59,573,229
Ensembl chr 9:59,548,683...59,573,229

G

sex hormone binding globulin

multiple interactions
affects binding

o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]
o,p'-DDT binds to SHBG protein

PMID:9171990 PMID:25349334

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

siah E3 ubiquitin protein ligase 2

increases expression

o,p'-DDT results in increased expression of SIAH2 mRNA

NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950

G

solute carrier family 10 member 1

decreases expression

o,p'-DDT results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 12 member 2

multiple interactions

[o,p'-DDT co-treated with DDT] results in increased expression of SLC12A2 mRNA

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 1 member 5

increases expression

o,p'-DDT results in increased expression of SLC1A5 mRNA

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 22 member 1

decreases expression

o,p'-DDT results in decreased expression of SLC22A1 mRNA

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 31 member 1

increases expression

o,p'-DDT results in increased expression of SLC31A1 mRNA

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

solute carrier family 35, member F5

increases expression

o,p'-DDT results in increased expression of SLC35F5 mRNA

NCBI chr13:36,992,118...37,028,549
Ensembl chr13:36,992,205...37,028,538

G

solute carrier family 38, member 1

increases expression

o,p'-DDT results in increased expression of SLC38A1 mRNA

NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218

G

solute carrier family 7 member 5

increases expression

o,p'-DDT results in increased expression of SLC7A5 mRNA

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

solute carrier family 8 member A1

multiple interactions

[o,p'-DDT co-treated with DDT] results in increased expression of SLC8A1 mRNA

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

G

solute carrier family 9 member A1

multiple interactions

[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A1 mRNA

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

G

solute carrier family 9 member A2

multiple interactions

[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A2 mRNA

NCBI chr 9:42,932,001...43,014,447
Ensembl chr 9:42,931,346...43,014,444

G

solute carrier family 9 member A3

multiple interactions

[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A3 mRNA

NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417

G

solute carrier organic anion transporter family, member 2a1

increases expression

o,p'-DDT results in increased expression of SLCO2A1 mRNA

NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546

G

survival of motor neuron 1, telomeric

increases expression

o,p'-DDT results in increased expression of SMN1 mRNA

NCBI chr 2:31,490,018...31,501,065
Ensembl chr 2:31,490,015...31,501,060

G

survival motor neuron domain containing 1

increases expression

o,p'-DDT results in increased expression of SMNDC1 mRNA

NCBI chr 1:252,389,675...252,400,749
Ensembl chr 1:252,389,673...252,401,616

G

superoxide dismutase 1

increases expression
decreases expression

o,p'-DDT analog results in increased expression of SOD1 mRNA
o,p'-DDT results in decreased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression

o,p'-DDT analog results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SPC25 component of NDC80 kinetochore complex

decreases expression

o,p'-DDT results in decreased expression of SPC25 mRNA

NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959

G

sphingosine kinase 2

increases expression
decreases expression

o,p'-DDT results in increased expression of SPHK2 mRNA
o,p'-DDT analog results in decreased expression of SPHK2 mRNA; o,p'-DDT results in decreased expression of SPHK2 mRNA

PMID:22937105 PMID:24096037

NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391

G

spectrin, beta, non-erythrocytic 1

decreases expression

o,p'-DDT results in decreased expression of SPTBN1 mRNA

NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507

G

squalene epoxidase

decreases expression

o,p'-DDT results in decreased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

sterol regulatory element binding transcription factor 1

affects expression

o,p'-DDT affects the expression of SREBF1 mRNA

PMID:17984292 PMID:18925944

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

ST14 transmembrane serine protease matriptase

increases expression

o,p'-DDT results in increased expression of ST14 mRNA

NCBI chr 8:29,540,805...29,581,704
Ensembl chr 8:29,540,811...29,581,517

G

steroidogenic acute regulatory protein

decreases expression

o,p'-DDT results in decreased expression of STAR mRNA

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

stanniocalcin 2

increases expression

o,p'-DDT results in increased expression of STC2 mRNA

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

stathmin 1

affects expression

o,p'-DDT affects the expression of STMN1 mRNA

PMID:17984292 PMID:18925944

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

sulfotransferase family 1E member 1

decreases expression

o,p'-DDT results in decreased expression of SULT1E1 mRNA

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

TATA-box binding protein associated factor 9b

increases expression

o,p'-DDT results in increased expression of TAF9B mRNA

NCBI chr X:71,289,290...71,300,142
Ensembl chr X:71,289,290...71,300,604

G

tyrosine aminotransferase

multiple interactions

o,p'-DDT inhibits the reaction [Hydrocortisone results in increased expression of TAT mRNA]

NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031

G

t-complex 1

increases expression

o,p'-DDT results in increased expression of TCP1 mRNA

NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839

G

telomerase reverse transcriptase

increases expression

o,p'-DDT results in increased expression of TERT mRNA

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transcription factor EC

increases expression

o,p'-DDT results in increased expression of TFEC mRNA

NCBI chr 4:45,106,129...45,180,236
Ensembl chr 4:45,107,641...45,180,236

G

trefoil factor 1

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]

PMID:8968093 PMID:18700809 PMID:20206645 PMID:22609851 PMID:23478948

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

trefoil factor 2

decreases expression

o,p'-DDT results in decreased expression of TFF2 mRNA

NCBI chr20:9,215,750...9,219,619
Ensembl chr20:9,215,761...9,219,619

G

transforming growth factor alpha

increases expression

o,p'-DDT results in increased expression of TGFA mRNA

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 2

decreases expression

o,p'-DDT results in decreased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

thrombomodulin

increases expression

o,p'-DDT results in increased expression of THBD mRNA

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

thrombospondin 1

increases expression

o,p'-DDT results in increased expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thyroid hormone receptor beta

multiple interactions

o,p'-DDT binds to and results in increased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

TIMP metallopeptidase inhibitor 1

decreases expression

o,p'-DDT results in decreased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

decreases expression

o,p'-DDT results in decreased expression of TIMP2 mRNA

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

transmembrane p24 trafficking protein 4

decreases expression

o,p'-DDT results in decreased expression of TMED4 mRNA

NCBI chr14:81,125,049...81,129,646
Ensembl chr14:81,125,053...81,129,631

G

tumor necrosis factor

multiple interactions
decreases expression
increases expression

[DDT co-treated with o,p'-DDT] results in decreased expression of TNF mRNA
o,p'-DDT analog results in decreased expression of TNF mRNA
o,p'-DDT results in increased expression of TNF mRNA

PMID:12007859 PMID:15104118 PMID:22937105

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11B

increases expression
decreases expression

o,p'-DDT results in increased expression of TNFRSF11B mRNA
o,p'-DDT analog results in decreased expression of TNFRSF11B mRNA

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF receptor superfamily member 14

increases expression

o,p'-DDT results in increased expression of TNFRSF14 mRNA

NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703

G

TNF receptor superfamily member 19

affects expression

o,p'-DDT affects the expression of TNFRSF19 mRNA

NCBI chr15:35,092,206...35,158,472
Ensembl chr15:35,092,206...35,180,795

G

TNF receptor superfamily member 1A

increases expression

o,p'-DDT results in increased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of TNFRSF1B mRNA
o,p'-DDT analog results in increased expression of TNFRSF1B mRNA; o,p'-DDT results in increased expression of TNFRSF1B mRNA

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

tumor necrosis factor receptor superfamily, member 22

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of TNFRSF10B mRNA
o,p'-DDT results in increased expression of TNFRSF10B mRNA

NCBI chr 1:198,840,452...198,860,713
Ensembl chr 1:198,840,453...198,856,309

G

TNF superfamily member 10

increases expression
decreases expression

o,p'-DDT results in increased expression of TNFSF10 mRNA
o,p'-DDT analog results in decreased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

TNF superfamily member 12

increases expression
decreases expression

o,p'-DDT results in increased expression of TNFSF12 mRNA
o,p'-DDT analog results in decreased expression of TNFSF12 mRNA

NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213

G

translocase of outer mitochondrial membrane 20

increases expression

o,p'-DDT results in increased expression of TOMM20 mRNA

NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198

G

tumor protein p53

increases expression

o,p'-DDT analog results in increased expression of TP53 mRNA; o,p'-DDT analog results in increased expression of TP53 protein; o,p'-DDT results in increased expression of TP53 mRNA; o,p'-DDT results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 binding protein, 2

increases expression
decreases expression

o,p'-DDT results in increased expression of TP53BP2 mRNA
o,p'-DDT analog results in decreased expression of TP53BP2 mRNA

NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432

G

tumor protein p63

increases expression
decreases expression

o,p'-DDT results in increased expression of TP63 mRNA
o,p'-DDT analog results in decreased expression of TP63 mRNA

NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398

G

tumor protein p73

increases expression
decreases expression

o,p'-DDT results in increased expression of TP73 mRNA
o,p'-DDT analog results in decreased expression of TP73 mRNA

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

G

TNFRSF1A-associated via death domain

increases expression
decreases expression

o,p'-DDT results in increased expression of TRADD mRNA
o,p'-DDT analog results in decreased expression of TRADD mRNA

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

Tnf receptor-associated factor 2

increases expression
decreases expression

o,p'-DDT results in increased expression of TRAF2 mRNA
o,p'-DDT analog results in decreased expression of TRAF2 mRNA

NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538

G

Tnf receptor-associated factor 3

increases expression

o,p'-DDT results in increased expression of TRAF3 mRNA

NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481

G

Tnf receptor associated factor 4

decreases expression
increases expression

o,p'-DDT analog results in decreased expression of TRAF4 mRNA
o,p'-DDT results in increased expression of TRAF4 mRNA

NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284

G

TSC22 domain family, member 1

decreases expression

o,p'-DDT results in decreased expression of TSC22D1 mRNA

NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958

G

TSC22 domain family, member 3

multiple interactions

o,p'-DDT inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]

NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861

G

tsukushi, small leucine rich proteoglycan

increases expression

o,p'-DDT results in increased expression of TSKU mRNA

NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588

G

tetraspanin 10

increases expression

o,p'-DDT results in increased expression of TSPAN10 mRNA

NCBI chr10:105,715,803...105,721,503
Ensembl chr10:105,715,961...105,719,813

G

tetraspanin 12

decreases expression

o,p'-DDT results in decreased expression of TSPAN12 mRNA

NCBI chr 4:50,313,768...50,389,246
Ensembl chr 4:50,313,772...50,389,246

G

tubulin, beta 2B class IIb

increases expression

o,p'-DDT results in increased expression of TUBB2B mRNA

NCBI chr17:30,747,734...30,750,781
Ensembl chr17:30,747,734...30,750,638

G

tubulin, beta 5 class I

increases expression

o,p'-DDT results in increased expression of TUBB5 mRNA

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

G

thioredoxin 1

affects expression

o,p'-DDT affects the expression of TXN1 mRNA

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin interacting protein

decreases expression

o,p'-DDT results in decreased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

affects expression

o,p'-DDT affects the expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

ubiquitin-conjugating enzyme E2F (putative)

increases expression

o,p'-DDT results in increased expression of UBE2F mRNA

NCBI chr 9:91,845,975...91,881,145
Ensembl chr 9:91,845,987...91,880,594

G

ubiquitin-conjugating enzyme E2L 3

increases expression

o,p'-DDT results in increased expression of UBE2L3 mRNA

NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862

G

ubiquitin specific peptidase 1

increases expression

o,p'-DDT results in increased expression of USP1 mRNA

NCBI chr 5:113,587,564...113,598,934
Ensembl chr 5:113,587,564...113,598,932

G

valosin containing protein lysine methyltransferase

decreases expression

o,p'-DDT results in decreased expression of VCPKMT mRNA

NCBI chr 6:88,036,485...88,042,151
Ensembl chr 6:88,036,494...88,042,000

G

vascular endothelial growth factor A

increases expression

o,p'-DDT results in increased expression of VEGFA mRNA

PMID:22609851 PMID:33728745

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

X-linked inhibitor of apoptosis

decreases expression

o,p'-DDT analog results in decreased expression of XIAP mRNA

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

zinc finger protein, multitype 2

increases methylation

o,p'-DDT results in increased methylation of ZFPM2 gene

NCBI chr 7:71,678,658...72,116,209
Ensembl chr 7:71,678,880...72,116,205

G

zinc finger with KRAB and SCAN domains 2

increases expression

o,p'-DDT results in increased expression of ZKSCAN2 mRNA

NCBI chr 1:178,006,003...178,028,239
Ensembl chr 1:178,009,238...178,028,131

G

zinc finger MYM-type containing 3

increases expression

o,p'-DDT results in increased expression of ZMYM3 mRNA

NCBI chr X:66,528,585...66,544,234
Ensembl chr X:66,528,585...66,544,782

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19922
chemical entity	19920
group	19878
polyatomic entity	19877
molecule	19770
cyclic compound	19535
organic cyclic compound	19545
organic aromatic compound	19380
diarylmethane	9457
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane	471
Path 2
Term	Annotations
CHEBI ontology	19922
subatomic particle	19892
composite particle	19892
hadron	19920
baryon	19892
nucleon	19920
atomic nucleus	19892
atom	19892
main group element atom	19866
p-block element atom	19866
p-block molecular entity	19866
carbon group molecular entity	19805
organic molecular entity	19775
organic molecule	19755
organic cyclic compound	19545
organic aromatic compound	19380
diarylmethane	9457
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane	471

paths to the root