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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:metallic base
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Accession:CHEBI:33977 term browser browse the term
Synonyms:related_synonym: metallic bases


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calcium dihydroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Calcium Hydroxide results in increased expression of ALPL mRNA CTD PMID:22083529 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Calcium Hydroxide results in increased expression of COL1A1 mRNA CTD PMID:22083529 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Calcium Hydroxide results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Polg DNA polymerase gamma, catalytic subunit affects expression ISO Calcium Hydroxide affects the expression of POLG mRNA CTD PMID:30615914 NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567 		JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit affects expression ISO Calcium Hydroxide affects the expression of POLG2 mRNA CTD PMID:30615914 NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008 		JBrowse link
G Tfam transcription factor A, mitochondrial affects expression ISO Calcium Hydroxide affects the expression of TFAM mRNA CTD PMID:30615914 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases expression ISO Calcium Hydroxide results in increased expression of TRPV1 mRNA CTD PMID:22083529 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
magnesium dihydroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions ISO [Aluminum Hydroxide co-treated with Magnesium Hydroxide] promotes the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine results in increased activity of CASP1 protein]; [Aluminum Hydroxide co-treated with Magnesium Hydroxide] promotes the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine results in increased expression of and results in increased secretion of CASP1 protein modified form]; CASP1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:18604214 PMID:22075093 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22750351 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22750351 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [Aluminum Hydroxide co-treated with Magnesium Hydroxide] inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein] CTD PMID:17404311 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form; [Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein; CASP1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL1B protein]
[[Aluminum Hydroxide co-treated with Magnesium Hydroxide] co-treated with N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein; IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]		 CTD PMID:17404311 PMID:18604214 PMID:22075093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions ISO IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:18604214 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein; N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]; TLR4 protein affects the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]] CTD PMID:22075093 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:18604214 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein] CTD PMID:18604214 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO TLR4 protein affects the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]]; TLR4 protein affects the susceptibility to [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] co-treated with N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine]; TLR4 protein affects the susceptibility to [Aluminum Hydroxide co-treated with Magnesium Hydroxide] CTD PMID:22075093 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
potassium hydroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfl1 cofilin 1 increases expression ISO potassium hydroxide results in increased expression of CFL1 mRNA; potassium hydroxide results in increased expression of CFL1 protein CTD PMID:21469165 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions
increases expression		 ISO potassium hydroxide results in decreased expression of and affects the localization of HSPB1 protein
potassium hydroxide results in increased expression of HSPB1 mRNA		 CTD PMID:21469165 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO potassium hydroxide results in increased expression of and results in increased secretion of IL1A protein CTD PMID:21469165 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
decreases expression		 ISO potassium hydroxide results in increased expression of SOD1 mRNA
potassium hydroxide results in decreased expression of SOD1 protein		 CTD PMID:21469165 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
sodium hydroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression		 EXP lycium barbarum polysaccharide inhibits the reaction [Sodium Hydroxide results in increased expression of ACTA2 protein] CTD PMID:38202631 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 EXP Sodium Hydroxide results in increased expression of CASP3 mRNA
lycium barbarum polysaccharide inhibits the reaction [Sodium Hydroxide results in increased expression of CASP3 mRNA]		 CTD PMID:38202631 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression
multiple interactions		 EXP Sodium Hydroxide results in increased expression of COL1A2 protein
lycium barbarum polysaccharide inhibits the reaction [Sodium Hydroxide results in increased expression of COL1A2 protein]		 CTD PMID:38202631 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
increases expression		 EXP lycium barbarum polysaccharide inhibits the reaction [Sodium Hydroxide results in increased expression of COL3A1 protein] CTD PMID:38202631 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Egfr epidermal growth factor receptor affects response to substance ISO EGFR SNP affects the susceptibility to Sodium Hydroxide CTD PMID:27206134 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ezr ezrin increases expression ISO Sodium Hydroxide results in increased expression of EZR mRNA CTD PMID:29893927 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Fn1 fibronectin 1 increases expression
multiple interactions		 EXP Sodium Hydroxide results in increased expression of FN1 protein
lycium barbarum polysaccharide inhibits the reaction [Sodium Hydroxide results in increased expression of FN1 protein]		 CTD PMID:38202631 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Ier3 immediate early response 3 affects response to substance ISO IER3 SNP affects the susceptibility to Sodium Hydroxide CTD PMID:27258892 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Sodium Hydroxide results in increased expression of IL1B protein CTD PMID:29953848 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il22 interleukin 22 affects response to substance ISO IL22 SNP affects the susceptibility to Sodium Hydroxide CTD PMID:27206134 NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP Sodium Hydroxide results in increased expression of JUN mRNA
lycium barbarum polysaccharide inhibits the reaction [Sodium Hydroxide results in increased expression of JUN mRNA]		 CTD PMID:38202631 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 increases activity
decreases response to substance		 ISO Sodium Hydroxide results in increased activity of KCNK3 protein
KCNK3 protein mutant form results in decreased susceptibility to Sodium Hydroxide		 CTD PMID:30365877 NCBI chr 6:25,761,487...25,799,153
Ensembl chr 6:25,763,228...25,799,153 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions		 EXP Sodium Hydroxide results in increased expression of MMP9 mRNA
lycium barbarum polysaccharide inhibits the reaction [Sodium Hydroxide results in increased expression of MMP9 mRNA]		 CTD PMID:38202631 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Plau plasminogen activator, urokinase affects response to substance ISO PLAU SNP affects the susceptibility to Sodium Hydroxide CTD PMID:27206134 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects response to substance ISO HLA-G SNP affects the susceptibility to Sodium Hydroxide CTD PMID:27258892 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Trim10 tripartite motif-containing 10 affects response to substance ISO TRIM10 SNP affects the susceptibility to Sodium Hydroxide CTD PMID:27258892 NCBI chr20:1,689,554...1,698,948
Ensembl chr20:1,689,562...1,698,252 		JBrowse link
G Trim31 tripartite motif-containing 31 affects response to substance ISO TRIM31 SNP affects the susceptibility to Sodium Hydroxide CTD PMID:27258892 NCBI chr20:1,653,165...1,666,494
Ensembl chr20:1,653,165...1,666,494 		JBrowse link
G Trim40 tripartite motif-containing 40 affects response to substance ISO TRIM40 SNP affects the susceptibility to Sodium Hydroxide CTD PMID:27258892 NCBI chr20:1,676,114...1,685,906
Ensembl chr20:1,676,270...1,685,214 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      molecular entity 19872
        inorganic molecular entity 19660
          inorganic hydroxy compound 766
            metallic base 38
              alkali metal hydroxide + 22
              alkaline earth hydroxide + 17
              ferric hydroxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      p-block molecular entity 19811
                        chalcogen molecular entity 19563
                          oxygen molecular entity 19535
                            hydroxides 19341
                              inorganic hydroxy compound 766
                                metallic base 38
                                  alkali metal hydroxide + 22
                                  alkaline earth hydroxide + 17
                                  ferric hydroxide 0
paths to the root