gold molecular entity - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	gold molecular entity	go back to main search page
Accession:	CHEBI:33969	browse the term
Synonyms:	related_synonym:	gold compounds; gold molecular entities

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Rat (617 ) Mouse (624 ) Human (639 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (617)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

ISO

Auranofin promotes the reaction [arsenite results in increased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

affects binding

ISO

Auranofin analog binds to ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

BCL2-antagonist/killer 1

multiple interactions
increases response to substance

ISO

[BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 results in increased susceptibility to Auranofin

PMID:18789312 PMID:21172426

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases response to substance

ISO

[BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAX results in increased susceptibility to Auranofin

PMID:18789312 PMID:21172426

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions
increases activity

ISO
EXP

Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Auranofin results in decreased expression of and results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]

PMID:15159275 PMID:15191400 PMID:18789312 PMID:20542334 PMID:21699084

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions

ISO

Auranofin results in decreased expression of and results in increased cleavage of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions

ISO

Auranofin results in decreased expression of and results in increased cleavage of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

CD274 molecule

decreases expression
multiple interactions

ISO

Auranofin results in decreased expression of CD274 protein
[PDCD1 protein affects the susceptibility to Auranofin] which affects the expression of CD274 protein

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951

G

CD8 subunit alpha

multiple interactions
increases expression

ISO

[PDCD1 protein affects the susceptibility to Auranofin] which affects the expression of CD8A protein
Auranofin results in increased expression of CD8A protein

NCBI chr 4:104,924,116...104,928,353
Ensembl chr 4:104,900,833...104,928,358

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

Auranofin results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

CCAAT/enhancer binding protein epsilon

multiple interactions

ISO

[Auranofin co-treated with Tretinoin] results in increased expression of CEBPE protein

NCBI chr15:32,139,716...32,141,476
Ensembl chr15:32,139,716...32,141,476

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

Auranofin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CHUK protein]; Auranofin inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]
Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

iodothyronine deiodinase 1

decreases activity

ISO

Auranofin results in decreased activity of DIO1 protein

NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771

G

epidermal growth factor

multiple interactions

ISO

Auranofin promotes the reaction [arsenite results in increased expression of and results in increased secretion of EGF protein]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

glutathione peroxidase 1

multiple interactions
increases expression

ISO

[Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]; Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione-disulfide reductase

multiple interactions

ISO

Auranofin promotes the reaction [arsenite results in increased activity of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

heme oxygenase 1

increases expression

ISO

Auranofin results in increased expression of HMOX1 mRNA
Auranofin results in increased expression of HMOX1 mRNA; Auranofin results in increased expression of HMOX1 protein

PMID:22008538 PMID:23942037

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

interleukin 1 beta

multiple interactions

ISO

Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 cytokine family signal transducer

multiple interactions

ISO

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein

NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182

G

interleukin-1 receptor-associated kinase 1

multiple interactions

ISO

Auranofin inhibits the reaction [lipopolysaccharide A results in increased degradation of IRAK1 protein]

NCBI chr X:156,919,927...156,929,825
Ensembl chr X:156,920,081...156,929,825

G

interferon regulatory factor 3

multiple interactions

ISO

Auranofin inhibits the reaction [lipopolysaccharide A results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [lipopolysaccharide A results in increased phosphorylation of IRF3 protein]; Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein]

NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401

G

integrin subunit alpha M

multiple interactions

ISO

[Auranofin co-treated with Tretinoin] results in increased expression of ITGAM protein

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

Janus kinase 2

multiple interactions

ISO

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

mitogen activated protein kinase 1

multiple interactions

ISO

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

ISO

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
decreases expression

ISO

[Auranofin co-treated with SN50 peptide] results in decreased expression of MCL1 protein
Auranofin results in decreased expression of MCL1 protein

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

Auranofin promotes the reaction [arsenite results in increased expression of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor beta

multiple interactions

ISO

Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]

NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:93,173,820...93,326,366

G

poly (ADP-ribose) polymerase 1

decreases activity
increases cleavage

ISO

Auranofin results in decreased activity of PARP1 protein
Auranofin results in increased cleavage of PARP1 protein

PMID:15159275 PMID:21370912

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

programmed cell death 1

affects response to substance
multiple interactions

ISO

PDCD1 protein affects the susceptibility to Auranofin
[PDCD1 protein affects the susceptibility to Auranofin] which affects the expression of CD274 protein; [PDCD1 protein affects the susceptibility to Auranofin] which affects the expression of CD8A protein; [PDCD1 protein affects the susceptibility to Auranofin] which affects the expression of PTGS2 protein

NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:101,866,126...101,879,270

G

peptidylprolyl isomerase F

increases oxidation
multiple interactions

ISO
EXP

Auranofin results in increased oxidation of PPIF protein
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PPIF protein]

NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,263,541...1,316,954

G

peroxiredoxin 3

increases oxidation
multiple interactions

ISO
EXP

Auranofin results in increased oxidation of PRDX3 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PRDX3 protein]
Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of PRDX3 protein]

PMID:18789312 PMID:21355852 PMID:26975474

NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

ISO

[lipopolysaccharide A co-treated with Auranofin] results in decreased expression of PTGS2 protein; [PDCD1 protein affects the susceptibility to Auranofin] which affects the expression of PTGS2 protein
Auranofin results in increased expression of PTGS2 protein
Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]

PMID:10594346 PMID:17034761 PMID:38636790

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RB transcriptional corepressor 1

decreases phosphorylation

ISO

Auranofin results in decreased phosphorylation of RB1 protein

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RNA binding motif, single stranded interacting protein 3

affects response to substance

ISO

RBMS3 protein affects the susceptibility to Auranofin

NCBI chr 8:125,183,311...125,970,239
Ensembl chr 8:125,183,315...126,503,586

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin promotes the reaction [arsenite results in increased phosphorylation of RELA protein]

PMID:10594346 PMID:36343453

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RT1 class II, locus Ba

increases response to substance

ISO

HLA-DQA1 gene polymorphism results in increased susceptibility to Auranofin

NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,576,843...4,581,653

G

RT1 class II, locus Db1

increases response to substance

ISO

HLA-DRB1 gene polymorphism results in increased susceptibility to Auranofin

NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165

G

solute carrier family 22 member 2

multiple interactions

ISO

Auranofin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

signal transducer and activator of transcription 3

decreases expression
multiple interactions

ISO

Auranofin results in decreased expression of STAT3 protein modified form
[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

TANK-binding kinase 1

multiple interactions

ISO

Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]

NCBI chr 7:58,963,319...58,996,357
Ensembl chr 7:58,963,325...58,996,357

G

transforming growth factor alpha

multiple interactions

ISO

Auranofin promotes the reaction [arsenite results in increased expression of and results in increased secretion of TGFA protein]

NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339

G

TIR domain containing adaptor molecule 1

multiple interactions

ISO

Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein]

NCBI chr 9:1,189,717...1,197,730
Ensembl chr 9:1,172,963...1,196,892

G

toll-like receptor 4

multiple interactions

ISO

Auranofin inhibits the reaction [lipopolysaccharide A promotes the reaction [TLR4 protein binds to TLR4 protein]]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions

ISO

Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]
Auranofin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:10820281 PMID:18789312

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

thioredoxin 1

increases oxidation
multiple interactions

ISO

Auranofin results in increased oxidation of TXN protein
Auranofin inhibits the reaction [arsenite results in increased expression of TXN protein]

PMID:26975474 PMID:36343453

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin 2

increases oxidation
multiple interactions

ISO
EXP

Auranofin results in increased oxidation of TXN2 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of TXN2 protein]

NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022

G

thioredoxin reductase 1

multiple interactions
decreases activity
increases oxidation
increases expression

ISO
EXP

Auranofin inhibits the reaction [arsenite results in increased expression of and results in increased activity of TXNRD1 protein]; Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]; Auranofin promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]; potassium tellurate(IV) promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]; Sodium Selenite promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]
Auranofin results in decreased activity of TXNRD1 protein
Auranofin results in increased expression of TXNRD1 mRNA

PMID:16510263 PMID:18405881 PMID:18789312 PMID:19486940 PMID:20457604 More...

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

thioredoxin reductase 2

multiple interactions
decreases activity

ISO
EXP

Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD2 protein]; Auranofin promotes the reaction [Sodium Selenite results in decreased expression of TXNRD2 mRNA]
Auranofin results in decreased activity of TXNRD2 protein

PMID:15458826 PMID:19486940 PMID:21172426 PMID:21355852

NCBI chr11:96,024,321...96,072,475
Ensembl chr11:96,024,324...96,072,475

gold nanoparticle

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor necrosis factor

decreases secretion

EXP

Topical GNP decreases secretion of Tnf protein in aqeous humor

RGD

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate-semialdehyde synthase

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of AASS mRNA
Gold analog results in decreased expression of AASS mRNA

PMID:28433809 PMID:36057382

NCBI chr 4:52,572,146...52,628,811
Ensembl chr 4:52,572,147...52,657,600

G

ATP binding cassette subfamily B member 1A

increases expression

ISO

Gold analog results in increased expression of ABCB1 mRNA

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily B member 4

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCB4 mRNA
Gold analog results in decreased expression of ABCB4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCC1 mRNA

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

increases expression

ISO

Gold analog results in increased expression of ABCC2 mRNA

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ABL1 mRNA

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846

G

acetyl-CoA acyltransferase 1A

decreases expression

ISO

Gold analog results in decreased expression of ACAA1 mRNA

NCBI chr 8:127,956,126...127,966,348
Ensembl chr 8:127,956,129...127,966,241

G

acetyl-CoA carboxylase alpha

decreases expression

ISO

Gold analog results in decreased expression of ACACA mRNA

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acyl-CoA dehydrogenase family, member 11

decreases expression

ISO

Gold analog results in decreased expression of ACAD11 mRNA

NCBI chr 8:113,560,142...113,625,346
Ensembl chr 8:113,560,196...113,625,352

G

acyl-CoA dehydrogenase medium chain

decreases expression

ISO

Gold analog results in decreased expression of ACADM mRNA

NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864

G

acyl-CoA dehydrogenase short chain

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADS mRNA

NCBI chr12:47,154,259...47,163,580
Ensembl chr12:47,154,276...47,164,103

G

acyl-CoA dehydrogenase, very long chain

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADVL mRNA

NCBI chr10:55,231,558...55,236,786
Ensembl chr10:55,231,440...55,236,750

G

aconitase 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of ACO1 mRNA

NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:60,055,866...60,112,600

G

aconitase 2

decreases expression
multiple interactions

ISO

Gold analog results in decreased expression of ACO2 protein
[Polyethyleneimine binds to Gold] which results in increased expression of ACO2 mRNA

PMID:24780912 PMID:28433809

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892

G

acyl-CoA oxidase 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ACOX1 mRNA

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

acyl-CoA oxidase 2

decreases expression

ISO

Gold analog results in decreased expression of ACOX2 mRNA

NCBI chr15:19,090,820...19,122,392
Ensembl chr15:19,090,926...19,122,392

G

acid phosphatase 1

decreases expression

ISO

Gold results in decreased expression of ACP1 mRNA

NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:53,233,948...53,251,959

G

activin A receptor type 1C

decreases expression

ISO

Gold results in decreased expression of ACVR1C mRNA

NCBI chr 3:63,224,322...63,301,252
Ensembl chr 3:63,227,559...63,301,205

G

ADAM metallopeptidase domain 28

increases expression

ISO

Gold results in increased expression of ADAM28 mRNA

NCBI chr15:50,184,286...50,250,605
Ensembl chr15:50,127,516...50,250,526

G

alcohol dehydrogenase 5 (class III), chi polypeptide

decreases expression

ISO

Gold results in decreased expression of ADH5 mRNA

NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:229,648,501...229,665,232

G

adiponectin receptor 2

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ADIPOR2 mRNA

NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666

G

adrenoceptor alpha 1B

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRA1B mRNA

NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,756,461...28,814,347

G

adrenoceptor beta 2

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRB2 mRNA

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

alpha-2-HS-glycoprotein

decreases expression

ISO

Gold analog results in decreased expression of AHSG mRNA

NCBI chr11:91,625,975...91,632,583
Ensembl chr11:91,625,975...91,634,039

G

apoptosis inducing factor, mitochondria associated 1

increases expression

ISO

Gold results in increased expression of AIFM1 protein

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

decreases expression

ISO

Gold results in decreased expression of AIMP1 mRNA

NCBI chr 2:223,825,930...223,849,477
Ensembl chr 2:223,825,931...223,849,994

G

adenylate kinase 3

decreases expression

ISO

Gold results in decreased expression of AK3 mRNA

NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183

G

A-kinase anchoring protein 13

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of AKAP13 mRNA

NCBI chr 1:138,722,445...139,029,401
Ensembl chr 1:138,724,150...139,029,401

G

aldo-keto reductase family 1 member B10

increases expression

ISO

Gold results in increased expression of AKR1B10 mRNA

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847

G

aldo-keto reductase family 1, member C2

increases expression

ISO

Gold results in increased expression of AKR1C2 mRNA

NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686

G

aldo-keto reductase family 1, member C3

increases expression

ISO

Gold results in increased expression of AKR1C3 mRNA

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438

G

AKT serine/threonine kinase 1

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

multiple interactions
increases expression

ISO

ALB protein results in increased uptake of [Polyethylene Glycols binds to Gold]; ALB protein results in increased uptake of [Polyethyleneimine binds to Gold]; ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
Gold analog results in increased expression of ALB mRNA

PMID:28433809 PMID:36057382

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

annexin A5

increases expression

ISO

Gold analog results in increased expression of ANXA5 protein

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400

G

apoptotic peptidase activating factor 1

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein
Gold analog results in decreased expression of APAF1 mRNA

PMID:27470402 PMID:28433809 PMID:36057382

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

apurinic/apyrimidinic endodeoxyribonuclease 1

decreases expression

ISO

Gold analog results in decreased expression of APEX1 mRNA

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

apolipoprotein A4

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of APOA4 mRNA

NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164

G

adenine phosphoribosyl transferase

decreases expression

ISO

Gold analog results in decreased expression of APRT protein

NCBI chr19:67,534,737...67,537,027

G

aquaporin 4

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of AQP4 mRNA

NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098

G

ARF like GTPase 1

decreases expression

ISO

Gold results in decreased expression of ARL1 mRNA

NCBI chr 7:25,007,401...25,018,572
Ensembl chr 7:25,006,981...25,019,319

G

ARF like GTPase 5B

decreases expression

ISO

Gold results in decreased expression of ARL5B mRNA

NCBI chr17:82,864,315...82,888,458
Ensembl chr17:82,864,287...82,890,646

G

arylsulfatase G

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ARSG mRNA

NCBI chr10:94,912,094...95,063,021
Ensembl chr10:94,913,152...95,042,447

G

N-acylsphingosine amidohydrolase 1

decreases expression

ISO

Gold analog results in decreased expression of ASAH1 mRNA

NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305

G

activating transcription factor 1

decreases expression

ISO

Gold results in decreased expression of ATF1 mRNA

NCBI chr 7:133,240,774...133,283,488
Ensembl chr 7:133,241,197...133,283,485

G

activating transcription factor 4

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

activating transcription factor 6

increases cleavage

ISO

Gold analog results in increased cleavage of ATF6 protein

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

decreases expression

ISO

Gold analog results in decreased expression of ATIC protein

NCBI chr 9:80,614,311...80,634,360
Ensembl chr 9:80,614,283...80,635,756

G

atlastin GTPase 2

decreases expression

ISO

Gold results in decreased expression of ATL2 mRNA

NCBI chr 6:20,891,220...20,932,644
Ensembl chr 6:20,891,227...20,933,320

G

ATM serine/threonine kinase

decreases expression

ISO

Gold analog results in decreased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATPase plasma membrane Ca2+ transporting 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ATP2B1 mRNA

NCBI chr 7:35,622,267...35,731,904
Ensembl chr 7:35,622,461...35,731,904

G

ATP synthase F1 subunit beta

multiple interactions

ISO

Gold analog results in increased expression of and results in decreased phosphorylation of ATP5F1B protein

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462

G

ATPase H+ transporting V1 subunit G2

decreases expression

ISO

Gold analog results in decreased expression of ATP6V1G2 mRNA

NCBI chr20:3,592,374...3,595,986
Ensembl chr20:3,592,364...3,595,475

G

ATR serine/threonine kinase

decreases expression

ISO

Gold analog results in decreased expression of ATR mRNA

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

beta-secretase 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BACE1 mRNA

NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918

G

BCL2-associated agonist of cell death

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in increased expression of BAD protein

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BAR/IMD domain containing adaptor protein 2

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of BAIAP2 mRNA

NCBI chr10:105,721,371...105,788,549
Ensembl chr10:105,721,417...105,788,549

G

BCL2-antagonist/killer 1

increases expression

ISO

Gold results in increased expression of BAK1 mRNA

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO
EXP

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; [Gold analog co-treated with Platinum] results in increased expression of BAX mRNA; [Polyethyleneimine binds to Gold] which results in decreased expression of BAX mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of BAX protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of BAX protein
Gold results in increased expression of BAX mRNA

PMID:21621595 PMID:22178767 PMID:25846798 PMID:27470402 PMID:27836789 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCAS2, pre-mRNA processing factor

decreases expression

ISO

Gold results in decreased expression of BCAS2 mRNA

NCBI chr 2:193,381,000...193,388,881
Ensembl chr 2:193,380,982...193,388,878

G

BCL2, apoptosis regulator

multiple interactions

ISO
EXP

[Gold analog co-treated with Platinum] results in decreased expression of BCL2 mRNA; [Quercetin analog co-treated with Gold analog] results in decreased expression of BCL2 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in decreased expression of BCL2 protein

PMID:25846798 PMID:27470402 PMID:27836789

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of BCL2L1 mRNA

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

decreases expression

ISO

Gold analog results in decreased expression of BCL2L11 mRNA

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

baculoviral IAP repeat-containing 2

decreases expression

ISO

Gold results in decreased expression of BIRC2 mRNA

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

baculoviral IAP repeat-containing 3

decreases expression

ISO

Gold analog results in decreased expression of BIRC3 mRNA; Gold results in decreased expression of BIRC3 mRNA

PMID:25523186 PMID:36057382

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

basic helix-loop-helix ARNT like 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BMAL1 mRNA

NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739

G

BMI1 proto-oncogene, polycomb ring finger

decreases expression

ISO

Gold results in decreased expression of BMI1 mRNA

NCBI chr17:86,240,683...86,250,044
Ensembl chr17:86,243,491...86,250,024

G

BRCA1, DNA repair associated

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA1 mRNA
Gold analog results in decreased expression of BRCA1 mRNA

PMID:28433809 PMID:36057382

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

BRCA2, DNA repair associated

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA2 mRNA
Gold analog results in decreased expression of BRCA2 mRNA

PMID:28433809 PMID:36057382

NCBI chr12:4,895,092...4,939,340
Ensembl chr12:4,895,447...4,936,194

G

C1D nuclear receptor corepressor

decreases expression

ISO

Gold results in decreased expression of C1D mRNA

NCBI chr14:95,862,550...95,874,796
Ensembl chr14:95,861,978...95,874,796

G

complement C3

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of C3 mRNA

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339

G

similar to human chromosome 11 open reading frame 54

decreases expression

ISO

Gold results in decreased expression of C11ORF54 mRNA

NCBI chr 8:20,405,240...20,427,811
Ensembl chr 8:20,405,241...20,427,811

G

complement C9

decreases expression

ISO

Gold analog results in decreased expression of C9 mRNA

NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:57,300,427...57,348,752

G

carbonic anhydrase 13

decreases expression

ISO

Gold results in decreased expression of CA13 mRNA

NCBI chr 2:88,649,643...88,680,763
Ensembl chr 2:88,649,625...88,680,763

G

capping actin protein of muscle Z-line subunit alpha 2

decreases expression

ISO

Gold results in decreased expression of CAPZA2 mRNA

NCBI chr 4:46,944,040...46,979,930
Ensembl chr 4:46,895,701...46,979,938

G

caspase 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of CASP1 mRNA

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 3

multiple interactions
increases activity
increases cleavage
increases expression

ISO
EXP

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP3 mRNA; [Polyethyleneimine binds to Gold] which results in increased expression of CASP3 mRNA; [Quercetin analog co-treated with Gold analog] results in increased cleavage of CASP3 protein; [Quercetin analog co-treated with Gold analog] results in increased expression of and results in increased activity of CASP3 protein; Dexamethasone promotes the reaction [Gold results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Gold results in increased activity of CASP3 protein]
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP3 protein
Gold analog results in increased cleavage of CASP3 protein
Gold results in increased expression of CASP3 mRNA

PMID:19760634 PMID:21621595 PMID:22178767 PMID:25846798 PMID:26551149 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 4

increases cleavage

ISO

Gold analog results in increased cleavage of CASP4 protein

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727

G

caspase 7

increases cleavage

ISO

Gold analog results in increased cleavage of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

increases expression
decreases expression

ISO

Gold results in increased expression of CASP8 mRNA
Gold analog results in decreased expression of CASP8 mRNA

PMID:22178767 PMID:36057382

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions
increases cleavage

ISO
EXP

[Gold analog co-treated with Platinum] results in increased activity of CASP9 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP9 mRNA
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP9 protein
Gold analog results in increased cleavage of CASP9 protein

PMID:25846798 PMID:26551149 PMID:27836789

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

ISO

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

chromobox 3

decreases expression

ISO

Gold results in decreased expression of CBX3 mRNA

NCBI chr 4:81,876,155...81,889,912
Ensembl chr 4:81,876,649...81,889,911

G

C-C motif chemokine ligand 2

multiple interactions
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL2 protein
Gold results in increased secretion of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 5

multiple interactions
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL5 protein
Gold results in increased secretion of CCL5 protein

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

C-C motif chemokine ligand 7

multiple interactions
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL7 protein
Gold results in increased secretion of CCL7 protein

NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947

G

cyclin D1

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

chaperonin containing TCP1 subunit 5

decreases expression

ISO

Gold analog results in decreased expression of CCT5 protein

NCBI chr 2:84,302,621...84,313,773
Ensembl chr 2:84,302,623...84,313,779

G

CD19 molecule

increases expression

ISO

Gold analog results in increased expression of CD19 mRNA

NCBI chr 1:190,417,853...190,424,494
Ensembl chr 1:190,417,853...190,424,355

G

CD36 molecule

decreases expression

ISO

Gold analog results in decreased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142

G

CD40 molecule

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of CD40 mRNA

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

CD86 molecule

decreases expression

ISO

Gold analog results in decreased expression of CD86 mRNA

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361

G

cytidine deaminase

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CDA mRNA

NCBI chr 5:155,839,929...155,866,541
Ensembl chr 5:155,839,929...155,866,541

G

cyclin-dependent kinase 1

decreases expression
increases expression

ISO

Gold results in decreased expression of CDK1 mRNA
Gold results in increased expression of CDK1 mRNA

PMID:25523186 PMID:29705079

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase 7

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of CDK7 mRNA

NCBI chr 2:33,574,623...33,599,485
Ensembl chr 2:33,574,623...33,599,485

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

ISO

[Gold binds to Dimethyldithiocarbamate] which results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

CDKN2A interacting protein

decreases expression

ISO

Gold results in decreased expression of CDKN2AIP mRNA

NCBI chr16:51,266,613...51,274,051
Ensembl chr16:51,268,896...51,274,049

G

cell growth regulator with ring finger domain 1

decreases expression

ISO

Gold results in decreased expression of CGRRF1 mRNA

NCBI chr15:22,560,902...22,588,815
Ensembl chr15:22,568,332...22,588,811

G

checkpoint kinase 1

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA
Gold analog results in decreased expression of CHEK1 mRNA

PMID:28433809 PMID:36057382

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

checkpoint kinase 2

decreases expression

ISO

Gold analog results in decreased expression of CHEK2 mRNA

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

cysteine and histidine rich domain containing 1

decreases expression

ISO

Gold results in decreased expression of CHORDC1 mRNA

NCBI chr 8:23,650,721...23,674,786
Ensembl chr 8:23,650,865...23,677,696

G

CDGSH iron sulfur domain 1

decreases expression

ISO

Gold results in decreased expression of CISD1 mRNA

NCBI chr20:17,254,462...17,267,843
Ensembl chr20:17,254,187...17,271,042

G

claudin 12

decreases expression

ISO

Gold results in decreased expression of CLDN12 mRNA

NCBI chr 4:29,477,468...29,488,465
Ensembl chr 4:29,477,342...29,493,776

G

CCHC-type zinc finger, nucleic acid binding protein

decreases expression

ISO

Gold results in decreased expression of CNBP mRNA

NCBI chr 4:121,860,102...121,868,976
Ensembl chr 4:121,860,105...121,869,010

G

CCR4-NOT transcription complex, subunit 7

decreases expression

ISO

Gold results in decreased expression of CNOT7 mRNA

NCBI chr16:58,478,882...58,498,046
Ensembl chr16:58,478,900...58,498,046

G

collagen type I alpha 1 chain

increases expression

ISO

Gold analog results in increased expression of COL1A1 protein

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type I alpha 2 chain

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL1A2 mRNA

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995

G

collagen type III alpha 1 chain

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL3A1 mRNA

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

COMM domain containing 8

decreases expression

ISO

Gold results in decreased expression of COMMD8 mRNA

NCBI chr14:36,403,000...36,413,577
Ensembl chr14:36,403,022...36,413,574

G

cytochrome c oxidase copper chaperone COX11

decreases expression

ISO

Gold results in decreased expression of COX11 mRNA

NCBI chr10:75,955,825...75,962,398
Ensembl chr10:75,955,783...75,963,489

G

cytochrome c oxidase copper chaperone COX17

decreases expression

ISO

Gold results in decreased expression of COX17 mRNA

NCBI chr11:75,906,245...75,912,036
Ensembl chr11:75,906,248...75,912,019

G

carnitine palmitoyltransferase 1A

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT1A mRNA

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

carnitine palmitoyltransferase 2

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT2 mRNA

NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818

G

carnitine O-octanoyltransferase

decreases expression

ISO

Gold analog results in decreased expression of CROT mRNA

NCBI chr 4:26,031,729...26,088,057
Ensembl chr 4:26,052,516...26,088,064

G

colony stimulating factor 2

multiple interactions
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF2 protein
Gold results in increased secretion of CSF2 protein

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

colony stimulating factor 3

increases secretion
multiple interactions

ISO

Gold results in increased secretion of CSF3 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF3 protein

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

CCCTC-binding factor

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CTCF mRNA

NCBI chr19:50,431,478...50,481,013
Ensembl chr19:50,431,689...50,481,012

G

cut-like homeobox 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CUX1 mRNA

NCBI chr12:25,728,393...26,062,497
Ensembl chr12:25,743,733...26,062,497

G

C-X-C motif chemokine ligand 10

increases secretion
multiple interactions

ISO

Gold results in increased secretion of CXCL10 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL10 protein

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 2

multiple interactions
increases secretion

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL2 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL2 protein
Gold results in increased secretion of CXCL2 protein

PMID:19695318 PMID:22155353

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL1 mRNA

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

cytochrome c, somatic

multiple interactions

ISO

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
decreases expression
multiple interactions

ISO

Gold analog results in increased activity of CYP1A1 protein
Gold analog results in decreased expression of CYP1A1 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of CYP1A1 mRNA

PMID:20193702 PMID:28433809 PMID:36057382

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 24, subfamily a, polypeptide 1

increases expression

ISO

Gold results in increased expression of CYP24A1 mRNA

NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:179,694,647...179,709,083

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA
Gold analog results in decreased expression of CYP2D6 mRNA

PMID:28433809 PMID:36057382

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

ISO

Gold analog results in decreased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450 family 7 subfamily A member 1

increases expression

ISO

Gold analog results in increased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytohesin 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of CYTH1 mRNA

NCBI chr10:103,901,376...103,984,496
Ensembl chr10:103,864,804...103,984,383

G

DAB adaptor protein 2

increases expression

ISO

Gold results in increased expression of DAB2 mRNA

NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:57,242,064...57,294,888

G

decapping mRNA 2

decreases expression

ISO

Gold results in decreased expression of DCP2 mRNA

NCBI chr18:37,001,615...37,037,949
Ensembl chr18:37,001,615...37,049,939

G

dopa decarboxylase

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DDC mRNA

NCBI chr14:90,592,304...90,682,830
Ensembl chr14:90,592,304...90,682,806

G

DNA-damage inducible transcript 3

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of DDIT4 mRNA

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

defensin beta 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of DEFB1 mRNA

NCBI chr16:77,001,326...77,016,068
Ensembl chr16:77,001,326...77,016,068

G

24-dehydrocholesterol reductase

multiple interactions
decreases expression

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DHCR24 mRNA
Gold analog results in decreased expression of DHCR24 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of DHCR24 mRNA

PMID:19695318 PMID:28433809 PMID:36057382

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

dihydrolipoamide dehydrogenase

decreases expression

ISO

Gold analog results in decreased expression of DLD mRNA

NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:53,619,631...53,652,354

G

dynein axonemal heavy chain 14

decreases expression

ISO

Gold results in decreased expression of DNAH14 mRNA

NCBI chr13:95,853,735...96,070,327
Ensembl chr13:95,854,534...96,070,330

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of DNAJA3 mRNA

NCBI chr10:11,361,168...11,386,599
Ensembl chr10:11,361,168...11,386,599

G

DnaJ heat shock protein family (Hsp40) member B14

decreases expression

ISO

Gold results in decreased expression of DNAJB14 mRNA

NCBI chr 2:229,032,415...229,075,905
Ensembl chr 2:229,032,286...229,075,922

G

DnaJ heat shock protein family (Hsp40) member B6

decreases expression

ISO

Gold results in decreased expression of DNAJB6 mRNA

NCBI chr 4:6,010,081...6,232,052
Ensembl chr 4:6,128,070...6,232,005

G

DnaJ heat shock protein family (Hsp40) member B9

decreases expression

ISO

Gold results in decreased expression of DNAJB9 mRNA

NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344

G

DnaJ heat shock protein family (Hsp40) member C10

decreases expression

ISO

Gold results in decreased expression of DNAJC10 mRNA

NCBI chr 3:85,636,890...85,679,620
Ensembl chr 3:85,639,589...85,689,368

G

DnaJ heat shock protein family (Hsp40) member C19

decreases expression

ISO

Gold results in decreased expression of DNAJC19 mRNA

NCBI chr 2:118,851,497...118,875,813
Ensembl chr 2:118,869,413...118,873,781

G

DnaJ heat shock protein family (Hsp40) member C21

decreases expression

ISO

Gold results in decreased expression of DNAJC21 mRNA

NCBI chr 2:61,146,669...61,173,908
Ensembl chr 2:61,145,142...61,174,126

G

DnaJ heat shock protein family (Hsp40) member C5

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of DNAJC5 mRNA

NCBI chr 3:188,999,508...189,033,455
Ensembl chr 3:188,999,470...189,034,089

G

dihydropyrimidinase-like 4

increases expression

ISO

Gold analog results in increased expression of DPYSL4 mRNA

NCBI chr 1:203,312,646...203,328,523
Ensembl chr 1:203,311,694...203,328,523

G

dopamine receptor D3

multiple interactions

EXP

Gold inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760

G

dopamine receptor D4

multiple interactions

EXP

Gold inhibits the reaction [3-N-methylspiperone binds to DRD4 protein]

NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:205,826,049...205,830,458

G

desmocollin 2

increases expression

ISO

Gold results in increased expression of DSC2 mRNA

NCBI chr18:11,725,466...11,757,591
Ensembl chr18:11,725,466...11,757,466

G

desmoglein 2

increases expression

ISO

Gold results in increased expression of DSG2 mRNA

NCBI chr18:12,121,287...12,179,590
Ensembl chr18:12,121,181...12,179,590

G

dual oxidase 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX1 mRNA

NCBI chr 3:129,714,125...129,749,186
Ensembl chr 3:129,714,149...129,749,187

G

dual oxidase 2

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX2 mRNA

NCBI chr 3:129,680,543...129,698,886
Ensembl chr 3:129,680,546...129,699,203

G

dual specificity phosphatase 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 11

decreases expression

ISO

Gold results in decreased expression of DUSP11 mRNA

NCBI chr 4:119,928,533...119,942,643
Ensembl chr 4:119,928,537...119,942,567

G

deoxyuridine triphosphatase

decreases expression

ISO

Gold results in decreased expression of DUT mRNA

NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:132,952,394...132,964,956

G

DAZ interacting zinc finger protein 3

decreases expression

ISO

Gold results in decreased expression of DZIP3 mRNA

NCBI chr11:65,286,190...65,356,314
Ensembl chr11:65,286,190...65,356,314

G

ER degradation enhancing alpha-mannosidase like protein 3

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of EDEM3 mRNA
Gold analog results in decreased expression of EDEM3 mRNA

PMID:28433809 PMID:36057382

NCBI chr13:66,403,022...66,470,496
Ensembl chr13:66,408,590...66,472,270

G

early endosome antigen 1

decreases expression

ISO

Gold results in decreased expression of EEA1 mRNA

NCBI chr 7:32,441,281...32,608,808
Ensembl chr 7:32,441,272...32,608,476

G

eukaryotic translation elongation factor 1 delta

decreases expression

ISO

Gold analog results in decreased expression of EEF1D protein

NCBI chr 7:109,462,645...109,478,021
Ensembl chr 7:109,462,646...109,489,531

G

eukaryotic translation elongation factor 2

decreases expression

ISO

Gold analog results in decreased expression of EEF2 protein

NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:9,183,961...9,189,544

G

epidermal growth factor

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

decreases expression

ISO

Gold analog results in decreased expression of EHHADH mRNA

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662

G

EP300 interacting inhibitor of differentiation 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of EID1 mRNA

NCBI chr 3:133,376,389...133,378,108
Ensembl chr 3:133,370,474...133,378,434

G

eukaryotic translation initiation factor 1A, X-linked

decreases expression

ISO

Gold results in decreased expression of EIF1AX mRNA

NCBI chr X:39,307,320...39,322,023
Ensembl chr X:39,307,137...39,322,021

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

ISO

Gold analog results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

eukaryotic translation initiation factor 4A2

decreases expression

ISO

Gold results in decreased expression of EIF4A2 mRNA

NCBI chr11:91,268,730...91,276,738
Ensembl chr11:91,268,731...91,275,323

G

eukaryotic translation initiation factor 4E

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in decreased expression of EIF4E protein

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

eukaryotic translation initiation factor 4E binding protein 3

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in increased expression of EIF4EBP3 protein

NCBI chr18:28,540,324...28,542,070
Ensembl chr18:28,540,058...28,542,061

G

eukaryotic translation initiation factor 5B

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of EIF5B mRNA
Gold analog results in decreased expression of EIF5B mRNA

PMID:28433809 PMID:36057382

NCBI chr 9:47,718,706...47,773,289
Ensembl chr 9:47,718,706...47,778,583

G

enolase 1

multiple interactions

ISO

Gold analog results in decreased expression of and results in increased phosphorylation of ENO1 protein

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

E1A binding protein p300

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; [Polyethyleneimine binds to Gold] which results in decreased expression of EP300 mRNA; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]

PMID:27634460 PMID:28433809

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

epithelial mitogen

increases expression

ISO

Gold results in increased expression of EPGN mRNA

NCBI chr14:17,360,968...17,369,000
Ensembl chr14:17,360,968...17,369,000

G

Eph receptor A1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of EPHA1 mRNA

NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:72,213,037...72,227,474

G

epoxide hydrolase 1

increases expression

ISO

Gold analog results in increased expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981

G

ERCC excision repair 2, TFIIH core complex helicase subunit

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ERCC2 mRNA

NCBI chr 1:88,161,342...88,175,102
Ensembl chr 1:88,160,988...88,175,102

G

ERCC excision repair 6, chromatin remodeling factor

decreases expression

ISO

Gold analog results in decreased expression of ERCC6 mRNA

NCBI chr16:7,771,311...7,841,895
Ensembl chr16:7,771,581...7,841,895

G

endoplasmic reticulum to nucleus signaling 1

increases phosphorylation

ISO

Gold analog results in increased phosphorylation of ERN1 protein

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

endoplasmic reticulum to nucleus signaling 2

increases expression

ISO

Gold analog results in increased expression of ERN2 mRNA

NCBI chr 1:186,153,115...186,174,521
Ensembl chr 1:186,157,691...186,174,521

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

ISO

Gold results in increased expression of ERO1A mRNA

NCBI chr15:20,974,771...21,010,170
Ensembl chr15:20,972,679...21,018,039

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

ISO

Gold results in decreased expression of ESCO2 mRNA

NCBI chr15:44,210,124...44,230,785
Ensembl chr15:44,210,641...44,231,304
Ensembl chr15:44,210,641...44,231,304

G

estrogen receptor 1

decreases expression

ISO

Gold analog results in decreased expression of ESR1 mRNA

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

ecotropic viral integration site 5

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of EVI5 mRNA

NCBI chr14:2,020,524...2,166,593
Ensembl chr14:2,020,581...2,166,593

G

even-skipped homeobox 1

increases expression

ISO

Gold results in increased expression of EVX1 mRNA

NCBI chr 4:82,747,192...82,751,569
Ensembl chr 4:82,746,993...82,751,569

G

FA complementation group L

decreases expression

ISO

Gold results in decreased expression of FANCL mRNA

NCBI chr14:104,449,403...104,515,297
Ensembl chr14:104,394,590...104,515,297

G

Fas cell surface death receptor

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of FAS mRNA
Gold analog results in decreased expression of FAS mRNA

PMID:28433809 PMID:36057382

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

fatty acid synthase

decreases expression

ISO

Gold analog results in decreased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

fibroblast growth factor 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of FGF1 mRNA

NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,939,870...30,961,393

G

fumarate hydratase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of FH mRNA

NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627

G

FKBP prolyl isomerase 9

increases phosphorylation
decreases expression

ISO

Gold analog results in increased phosphorylation of FKBP9 protein
Gold analog results in decreased expression of FKBP9 protein

NCBI chr 4:87,436,439...87,486,909
Ensembl chr 4:87,436,478...87,508,940

G

flavin containing dimethylaniline monoxygenase 5

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of FMO5 mRNA

NCBI chr 2:187,885,741...187,938,468
Ensembl chr 2:187,910,964...187,938,464

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO

[Gold co-treated with Silicon Dioxide] results in increased expression of FOS mRNA
Gold results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

ferritin heavy chain 1

increases expression

ISO

Gold results in increased expression of FTH1 mRNA

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

FYN binding protein 1

increases expression

ISO

Gold results in increased expression of FYB1 mRNA

NCBI chr 2:57,360,084...57,508,609
Ensembl chr 2:57,360,096...57,508,608

G

frizzled class receptor 4

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of FZD4 mRNA

NCBI chr 1:152,692,507...152,701,372
Ensembl chr 1:152,692,507...152,701,372

G

G2/M-phase specific E3 ubiquitin protein ligase

decreases expression

ISO

Gold results in decreased expression of G2E3 mRNA

NCBI chr 6:74,498,801...74,530,703
Ensembl chr 6:74,503,109...74,528,198

G

polypeptide N-acetylgalactosaminyltransferase 1

decreases expression

ISO

Gold results in decreased expression of GALNT1 mRNA

NCBI chr18:15,763,697...15,843,598
Ensembl chr18:15,764,277...15,843,588

G

polypeptide N-acetylgalactosaminyltransferase 5

decreases expression

ISO

Gold analog results in decreased expression of GALNT5 mRNA

NCBI chr 3:62,982,465...63,028,724
Ensembl chr 3:62,982,465...63,028,724

G

glucosidase, alpha; neutral C

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of GANC mRNA

NCBI chr 3:127,807,132...127,858,995
Ensembl chr 3:127,807,441...127,859,859

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

ISO

Gold analog results in decreased expression of GAPDH protein

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

grancalcin

decreases expression

ISO

Gold results in decreased expression of GCA mRNA

NCBI chr 3:67,705,874...67,738,475
Ensembl chr 3:67,705,890...67,737,387

G

glutaryl-CoA dehydrogenase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of GCDH mRNA

NCBI chr19:40,168,038...40,174,536
Ensembl chr19:40,168,141...40,175,686

G

guanine monophosphate synthase

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of GMPS mRNA

NCBI chr 2:150,587,824...150,641,564
Ensembl chr 2:150,587,854...150,648,986

G

G protein subunit gamma 10

decreases expression

ISO

Gold results in decreased expression of GNG10 mRNA

NCBI chr 5:78,651,167...78,658,060
Ensembl chr 5:78,651,167...78,658,059

G

glutamic-oxaloacetic transaminase 2

decreases expression

ISO

Gold analog results in decreased expression of GOT2 protein

NCBI chr19:9,180,428...9,206,113
Ensembl chr19:9,180,431...9,206,111

G

G protein-coupled receptor 182

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of GPR182 mRNA

NCBI chr 7:65,471,254...65,474,110
Ensembl chr 7:65,452,965...65,474,998

G

glutamic--pyruvic transaminase

multiple interactions
decreases expression

ISO

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; [Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]
Gold analog results in decreased expression of GPT mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of GPT mRNA

PMID:27836789 PMID:28433809 PMID:36057382

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 2

increases expression

ISO

Gold analog results in increased expression of GPX2 mRNA; Gold results in increased expression of GPX2 mRNA

PMID:25523186 PMID:36057382

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutathione peroxidase 3

increases expression

ISO

Gold analog results in increased expression of GPX3 mRNA

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405

G

gelsolin

decreases expression
increases degradation

ISO

Gold analog results in decreased expression of GSN protein
Gold analog results in increased degradation of GSN protein

PMID:24780912 PMID:26551149

NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:38,982,671...39,035,850

G

glutathione S-transferase mu 4

multiple interactions
increases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of GSTM4 mRNA
Gold analog results in increased expression of GSTM4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:198,358,744...198,373,638

G

3-hydroxyanthranilate 3,4-dioxygenase

increases expression

ISO

Gold analog results in increased expression of HAAO mRNA

NCBI chr 6:16,598,325...16,617,590
Ensembl chr 6:16,598,087...16,617,356

G

histone acetyltransferase 1

decreases expression

ISO

Gold results in decreased expression of HAT1 mRNA

NCBI chr 3:76,624,442...76,672,701
Ensembl chr 3:76,624,869...76,672,696

G

hepatitis A virus cellular receptor 1

multiple interactions

ISO

[Polyethylene Glycols binds to Gold] which results in increased expression of HAVCR1 protein; [Polyethyleneimine binds to Gold] which results in increased expression of HAVCR1 protein; [Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

hydroxycarboxylic acid receptor 2

increases expression

ISO

Gold results in increased expression of HCAR2 mRNA

NCBI chr12:38,387,163...38,389,149
Ensembl chr12:38,387,230...38,389,391

G

hexosaminidase subunit beta

multiple interactions

EXP

[gold chloride results in increased abundance of Gold] which results in increased export of HEXB protein; [gold tetrachloride, acid results in increased abundance of Gold] which results in increased export of HEXB protein

NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771

G

high mobility group box 2

decreases expression

ISO

Gold results in decreased expression of HMGB2 mRNA

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860

G

heme oxygenase 1

increases expression

ISO

Gold results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

homeobox A3

decreases expression

ISO

Gold analog results in decreased expression of HOXA3 mRNA

NCBI chr 4:82,599,860...82,643,831
Ensembl chr 4:82,599,860...82,643,831

G

hypoxanthine phosphoribosyltransferase 1

decreases expression

ISO

Gold results in decreased expression of HPRT1 mRNA

NCBI chr X:137,655,744...137,687,718
Ensembl chr X:137,655,680...137,687,712

G

hemopexin

decreases expression

ISO

Gold analog results in decreased expression of HPX mRNA

NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:169,344,583...169,352,156

G

heat shock factor binding protein 1

decreases expression

ISO

Gold results in decreased expression of HSBP1 mRNA

NCBI chr19:64,309,703...64,314,035
Ensembl chr19:64,309,703...64,314,035

G

heat shock transcription factor 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of HSF1 mRNA

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

heat shock protein 90 alpha family class B member 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 13

decreases expression

ISO

Gold results in decreased expression of HSPA13 mRNA

NCBI chr11:27,862,717...27,876,898
Ensembl chr11:27,862,593...27,876,898

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 2

decreases expression

ISO

Gold analog results in decreased expression of HSPA2 mRNA

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133

G

heat shock protein family A (Hsp70) member 4

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSPA4 mRNA

NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,908,866...37,949,835

G

heat shock protein family A (Hsp70) member 8

increases expression

ISO

Gold analog results in increased expression of HSPA8 protein

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

heat shock protein family A (Hsp70) member 9

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of HSPA9 mRNA

NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398

G

heat shock protein family B (small) member 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSPB1 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of HSPB1 mRNA

PMID:19695318 PMID:28433809

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family D (Hsp60) member 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of HSPD1 mRNA

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

HIV-1 Tat interactive protein 2

increases expression

ISO

Gold results in increased expression of HTATIP2 mRNA

NCBI chr 1:108,609,424...108,624,810
Ensembl chr 1:108,605,811...108,624,815

G

HIV-1 Tat specific factor 1

decreases expression

ISO

Gold results in decreased expression of HTATSF1 mRNA

NCBI chr X:139,972,742...139,986,923
Ensembl chr X:139,972,742...139,986,923

G

HtrA serine peptidase 4

decreases expression

ISO

Gold analog results in decreased expression of HTRA4 mRNA

NCBI chr16:73,704,255...73,717,722
Ensembl chr16:73,704,184...73,717,722

G

hypoxia up-regulated 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of HYOU1 mRNA

NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:53,602,604...53,614,997

G

isocitrate dehydrogenase (NADP(+)) 1

multiple interactions

ISO

Gold analog results in decreased expression of and results in increased phosphorylation of IDH1 protein

NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:74,027,892...74,049,555

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of IDH3G mRNA

NCBI chr X:156,666,573...156,675,482
Ensembl chr X:156,666,577...156,675,799

G

interferon gamma receptor 1

increases expression

ISO

Gold results in increased expression of IFNGR1 mRNA

NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:16,152,879...16,171,437

G

insulin-like growth factor 1

multiple interactions

ISO

Gold inhibits the reaction [IGF1 protein binds to IGF1R protein]

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor 1 receptor

multiple interactions

ISO

Gold inhibits the reaction [IGF1 protein binds to IGF1R protein]; Gold inhibits the reaction [IGF2 protein binds to IGF1R protein]

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

insulin-like growth factor 2

multiple interactions

ISO

Gold inhibits the reaction [IGF2 protein binds to IGF1R protein]

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:207,243,873...207,260,667

G

IKAROS family zinc finger 2

decreases expression

ISO

Gold results in decreased expression of IKZF2 mRNA

NCBI chr 9:78,495,670...78,640,896
Ensembl chr 9:78,492,275...78,640,463

G

interleukin 10

multiple interactions
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of IL10 protein
Gold results in increased secretion of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 alpha

multiple interactions
decreases expression
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of IL1A protein
Gold analog results in decreased expression of IL1A mRNA
Gold results in increased secretion of IL1A protein

PMID:22155353 PMID:36057382

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions
decreases expression
increases secretion

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL1B mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of IL1B protein
Gold analog results in decreased expression of IL1B mRNA
Gold results in increased secretion of IL1B protein

PMID:19695318 PMID:22155353 PMID:36057382

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 4

decreases expression

ISO

Gold analog results in decreased expression of IL4 mRNA

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions
increases secretion

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL6 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of IL6 protein
[Polyethylene Glycols binds to Gold] which results in increased expression of IL6 protein; [Polyethyleneimine binds to Gold] which results in increased expression of IL6 protein; [Thioctic Acid binds to Gold] which results in increased expression of IL6 protein
Gold results in increased secretion of IL6 protein

PMID:19695318 PMID:22155353 PMID:28433809

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL6RA mRNA

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

inositol monophosphatase 1

decreases expression

ISO

Gold results in decreased expression of IMPA1 mRNA

NCBI chr 2:93,370,200...93,391,474
Ensembl chr 2:93,370,299...93,391,468

G

inositol polyphosphate multikinase

decreases expression

ISO

Gold results in decreased expression of IPMK mRNA

NCBI chr20:17,216,151...17,250,826
Ensembl chr20:17,216,151...17,250,757

G

IQ motif containing GTPase activating protein 2

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of IQGAP2 mRNA

NCBI chr 2:28,629,558...28,904,649
Ensembl chr 2:28,629,558...28,904,649

G

jagged canonical Notch ligand 1

decreases expression

ISO

Gold analog results in decreased expression of JAG1 mRNA

NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872

G

Janus kinase 2

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of JAK2 protein

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

junction plakoglobin

decreases expression

ISO

Gold analog results in decreased expression of JUP protein

NCBI chr10:85,800,812...85,827,881
Ensembl chr10:85,800,814...85,827,429

G

ketohexokinase

increases expression

ISO

Gold analog results in increased expression of KHK mRNA

NCBI chr 6:31,165,246...31,175,779
Ensembl chr 6:31,165,248...31,175,481

G

Kin17 DNA and RNA binding protein

decreases expression

ISO

Gold results in decreased expression of KIN mRNA

NCBI chr17:73,323,189...73,333,542
Ensembl chr17:73,322,801...73,333,542

G

KIT ligand

decreases expression

ISO

Gold results in decreased expression of KITLG mRNA

NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:36,782,638...36,863,793

G

KRR1, small subunit processome component homolog

decreases expression

ISO

Gold results in decreased expression of KRR1 mRNA

NCBI chr 7:49,361,794...49,374,222
Ensembl chr 7:49,361,901...49,374,216

G

kynureninase

increases expression

ISO

Gold results in increased expression of KYNU mRNA

NCBI chr 3:48,188,286...48,338,996
Ensembl chr 3:48,188,182...48,339,014

G

laccase domain containing 1

increases expression

ISO

Gold results in increased expression of LACC1 mRNA

NCBI chr15:58,799,477...58,816,840
Ensembl chr15:58,786,637...58,816,840

G

lactamase, beta 2

decreases expression

ISO

Gold results in decreased expression of LACTB2 mRNA

NCBI chr 5:10,352,165...10,374,928
Ensembl chr 5:10,352,154...10,379,255

G

La ribonucleoprotein 1B

decreases expression

ISO

Gold results in decreased expression of LARP1B mRNA

NCBI chr 2:125,860,935...125,897,189
Ensembl chr 2:125,863,997...125,897,189

G

LIF, interleukin 6 family cytokine

multiple interactions
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of LIF protein
Gold results in increased secretion of LIF protein

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053

G

DNA ligase 4

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which affects the expression of LIG4 mRNA

NCBI chr16:86,220,345...86,228,930
Ensembl chr16:86,220,279...86,229,926

G

LIM domain and actin binding 1

decreases expression

ISO

Gold results in decreased expression of LIMA1 mRNA

NCBI chr 7:132,780,556...132,880,343
Ensembl chr 7:132,780,556...132,880,386

G

lectin, mannose-binding, 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of LMAN1 mRNA

NCBI chr18:61,778,971...61,800,960
Ensembl chr18:61,772,917...61,800,820

G

lamin A/C

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of LMNA mRNA

NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:176,237,564...176,288,072

G

lamin B1

increases degradation

ISO

Gold analog results in increased degradation of LMNB1 protein

NCBI chr18:52,373,939...52,413,284
Ensembl chr18:52,373,757...52,413,283

G

lysophosphatidylglycerol acyltransferase 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of LPGAT1 mRNA

NCBI chr13:105,825,630...105,896,366
Ensembl chr13:105,820,468...105,896,364

G

LRAT domain containing 1

increases expression

ISO

Gold results in increased expression of LRATD1 mRNA

NCBI chr 6:42,646,515...42,650,988
Ensembl chr 6:42,640,190...42,651,204

G

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

ISO

Gold results in decreased expression of LSM5 mRNA

NCBI chr 4:87,281,260...87,284,476
Ensembl chr 4:87,281,260...87,284,476
Ensembl chr 6:87,281,260...87,284,476

G

LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

ISO

Gold results in decreased expression of LSM6 mRNA

NCBI chr19:46,002,592...46,017,152

G

lanosterol synthase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of LSS mRNA

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253

G

mitotic arrest deficient 2 like 1

decreases expression

ISO

Gold results in decreased expression of MAD2L1 mRNA

NCBI chr 4:97,236,419...97,247,603
Ensembl chr 4:97,236,503...97,243,222

G

microtubule-associated protein 1B

increases expression

ISO

Gold results in increased expression of MAP1B mRNA

NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:32,551,423...32,657,094

G

mitogen activated protein kinase kinase 1

multiple interactions

ISO

MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

muscleblind-like splicing regulator 2

decreases expression

ISO

Gold results in decreased expression of MBNL2 mRNA

NCBI chr15:103,792,134...103,949,827
Ensembl chr15:103,792,152...103,949,827

G

malate dehydrogenase 1B

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of MDH1B mRNA
Gold analog results in decreased expression of MDH1B mRNA

PMID:28433809 PMID:36057382

NCBI chr 9:72,614,185...72,661,820
Ensembl chr 9:72,613,340...72,661,745

G

MDM2 proto-oncogene

decreases expression

ISO

Gold analog results in decreased expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

mitochondrial trans-2-enoyl-CoA reductase

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MECR mRNA

NCBI chr 5:149,313,765...149,339,964
Ensembl chr 5:149,313,774...149,342,825

G

MEFV innate immunity regulator, pyrin

increases expression

ISO

Gold results in increased expression of MEFV mRNA

NCBI chr10:12,288,514...12,303,337
Ensembl chr10:12,293,782...12,303,333

G

methionyl aminopeptidase 2

decreases expression

ISO

Gold analog results in decreased expression of METAP2 mRNA; Gold results in decreased expression of METAP2 mRNA

PMID:25523186 PMID:36057382

NCBI chr 7:30,299,433...30,327,477
Ensembl chr 7:30,299,433...30,327,521

G

marker of proliferation Ki-67

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of MKI67 mRNA
Gold analog results in decreased expression of MKI67 mRNA

PMID:28433809 PMID:36057382

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

membrane magnesium transporter 1

decreases expression

ISO

Gold results in decreased expression of MMGT1 mRNA

NCBI chr X:139,445,834...139,458,169
Ensembl chr X:139,445,834...139,458,169

G

matrix metallopeptidase 3

increases expression

ISO

Gold results in increased expression of MMP3 mRNA

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826

G

matrix metallopeptidase 9

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

MNAT1 component of CDK activating kinase

decreases expression

ISO

Gold results in decreased expression of MNAT1 mRNA

NCBI chr 6:97,550,566...97,706,598
Ensembl chr 6:97,550,543...97,706,595

G

MOB kinase activator 1B

decreases expression

ISO

Gold results in decreased expression of MOB1B mRNA

NCBI chr14:19,617,136...19,649,919
Ensembl chr14:19,610,445...19,649,919

G

MOB family member 4, phocein

decreases expression

ISO

Gold results in decreased expression of MOB4 mRNA

NCBI chr 9:64,111,170...64,135,740
Ensembl chr 9:64,111,718...64,135,779

G

MORC family CW-type zinc finger 3

decreases expression

ISO

Gold results in decreased expression of MORC3 mRNA

NCBI chr11:46,621,575...46,664,315
Ensembl chr11:46,621,548...46,664,309

G

mitochondrial ribosomal protein L3

decreases expression

ISO

Gold results in decreased expression of MRPL3 mRNA

NCBI chr 8:114,548,970...114,572,330
Ensembl chr 8:114,548,970...114,573,996

G

mitochondrial ribosomal protein S6

decreases expression

ISO

Gold results in decreased expression of MRPS6 mRNA

NCBI chr11:44,778,667...44,834,420
Ensembl chr11:44,781,554...44,834,962

G

metallothionein 1, pseudogene 3

increases expression

ISO

Gold results in increased expression of MT1E mRNA

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:79,695,809...79,696,200

G

metallothionein 2

increases expression

ISO

Gold results in increased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

methylenetetrahydrofolate reductase

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MTHFR mRNA

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105

G

myotubularin related protein 6

decreases expression

ISO

Gold results in decreased expression of MTMR6 mRNA

NCBI chr15:38,596,091...38,634,023
Ensembl chr15:38,596,032...38,636,672

G

mechanistic target of rapamycin kinase

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of MTOR protein

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

MTSS I-BAR domain containing 1

increases expression

ISO

Gold results in increased expression of MTSS1 mRNA

NCBI chr 7:92,378,228...92,517,444
Ensembl chr 7:92,378,238...92,517,303

G

microsomal triglyceride transfer protein

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of MTTP mRNA

NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650

G

MYCL proto-oncogene, bHLH transcription factor

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MYCL mRNA

NCBI chr 5:140,559,843...140,566,704
Ensembl chr 5:140,560,152...140,566,699

G

myoneurin

decreases expression

ISO

Gold results in decreased expression of MYNN mRNA

NCBI chr 2:114,708,150...114,726,450
Ensembl chr 2:114,708,156...114,725,452

G

N-acyl phosphatidylethanolamine phospholipase D

decreases expression

ISO

Gold results in decreased expression of NAPEPLD mRNA

NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:14,252,692...14,291,014

G

neutral cholesterol ester hydrolase 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of NCEH1 mRNA

NCBI chr 2:112,003,677...112,064,274
Ensembl chr 2:112,003,502...112,064,272

G

NFE2 like bZIP transcription factor 2

increases activity
increases expression

ISO

Gold results in increased activity of NFE2L2 promoter
Gold analog results in increased expression of NFE2L2 mRNA; Gold analog results in increased expression of NFE2L2 protein

PMID:21643505 PMID:36057382

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

decreases expression

ISO

Gold analog results in decreased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor delta

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of NFKBID mRNA

NCBI chr 1:94,808,459...94,824,726
Ensembl chr 1:94,808,453...94,817,861

G

NFKB inhibitor zeta

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of NFKBIZ mRNA

NCBI chr11:58,251,720...58,279,767
Ensembl chr11:58,251,721...58,279,767

G

NIPBL, cohesin loading factor

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of NIPBL mRNA

NCBI chr 2:59,126,676...59,314,841
Ensembl chr 2:59,126,676...59,293,277

G

nitric oxide synthase 2

increases expression

ISO

Gold results in increased expression of NOS2 protein

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NPL4 homolog, ubiquitin recognition factor

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of NPLOC4 mRNA

NCBI chr10:106,152,756...106,208,306
Ensembl chr10:106,153,173...106,208,264

G

nucleophosmin 1

decreases expression

ISO

Gold results in decreased expression of NPM1 mRNA

NCBI chr10:18,245,739...18,255,913
Ensembl chr10:18,245,740...18,256,024
Ensembl chr X:18,245,740...18,256,024

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of NQO1 mRNA
Gold analog results in increased expression of NQO1 mRNA; Gold results in increased expression of NQO1 mRNA

PMID:28433809 PMID:29705079 PMID:36057382

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

ISO

Gold analog results in decreased expression of NR0B2 mRNA

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

nuclear receptor subfamily 4, group A, member 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

neuronal cell adhesion molecule

increases expression

ISO

Gold results in increased expression of NRCAM mRNA

NCBI chr 6:67,129,723...67,425,510
Ensembl chr 6:67,129,801...67,430,539

G

nuclear receptor interacting protein 1

increases expression

ISO

Gold results in increased expression of NRIP1 mRNA

NCBI chr11:28,382,835...28,466,483
Ensembl chr11:28,378,878...28,467,353

G

netrin 4

increases expression

ISO

Gold results in increased expression of NTN4 mRNA

NCBI chr 7:30,073,637...30,187,407
Ensembl chr 7:30,073,333...30,188,309

G

nucleobindin 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of NUCB1 mRNA

NCBI chr 1:105,104,793...105,135,730
Ensembl chr 1:105,104,793...105,135,837

G

nudix hydrolase 1

decreases expression

ISO

Gold analog results in decreased expression of NUDT1 mRNA

NCBI chr12:19,416,411...19,423,448
Ensembl chr12:19,416,411...19,424,158

G

nudix hydrolase 12

decreases expression

ISO

Gold results in decreased expression of NUDT12 mRNA

NCBI chr 9:106,188,930...106,202,340
Ensembl chr 9:106,189,661...106,202,340

G

nudix hydrolase 13

decreases expression

ISO

Gold analog results in decreased expression of NUDT13 mRNA

NCBI chr15:4,050,979...4,071,605
Ensembl chr15:4,050,980...4,071,476

G

nucleoporin 210

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of NUP210 mRNA

NCBI chr 4:125,068,736...125,167,238
Ensembl chr 4:125,068,736...125,167,047

G

ORC ubiquitin ligase 1

decreases expression

ISO

Gold results in decreased expression of OBI1 mRNA

NCBI chr15:87,684,022...87,723,342
Ensembl chr15:87,684,025...87,723,342

G

odr-4 GPCR localization factor homolog

decreases expression

ISO

Gold results in decreased expression of ODR4 mRNA

NCBI chr13:64,925,573...64,974,395
Ensembl chr13:64,944,713...64,974,316

G

oxoglutarate dehydrogenase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of OGDH mRNA

NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271

G

8-oxoguanine DNA glycosylase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of OGG1 mRNA

NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604

G

origin recognition complex, subunit 4

decreases expression

ISO

Gold results in decreased expression of ORC4 mRNA

NCBI chr 3:53,700,046...53,743,293
Ensembl chr 3:53,703,615...53,742,264

G

OS9, endoplasmic reticulum lectin

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of OS9 mRNA

NCBI chr 7:64,802,517...64,829,185
Ensembl chr 7:64,802,103...64,829,070

G

oxidative stress induced growth inhibitor 1

increases expression

ISO

Gold results in increased expression of OSGIN1 mRNA

NCBI chr19:64,380,336...64,409,165
Ensembl chr19:64,401,173...64,409,162

G

prolyl 4-hydroxylase subunit beta

decreases expression

ISO

Gold analog results in decreased expression of P4HB protein

NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911

G

poly (ADP-ribose) polymerase 1

multiple interactions
decreases expression

ISO

Organogold Compounds promotes the reaction [Gold binds to PARP1 protein]
Gold analog results in decreased expression of PARP1 mRNA

PMID:21370912 PMID:36057382

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

poly(rC) binding protein 1

decreases expression

ISO

Gold analog results in decreased expression of PCBP1 protein

NCBI chr 4:120,530,100...120,532,107
Ensembl chr 4:120,529,172...120,539,111

G

propionyl-CoA carboxylase subunit alpha

decreases expression

ISO

Gold analog results in decreased expression of PCCA mRNA

NCBI chr15:106,034,586...106,374,908
Ensembl chr15:106,034,610...106,374,908

G

polycomb group ring finger 5

decreases expression

ISO

Gold results in decreased expression of PCGF5 mRNA

NCBI chr 1:243,476,450...243,592,603
Ensembl chr 1:243,476,261...243,587,869

G

polycomb group ring finger 6

decreases expression

ISO

Gold results in decreased expression of PCGF6 mRNA

NCBI chr 1:255,866,709...255,886,306
Ensembl chr 1:255,866,711...255,886,266

G

proliferating cell nuclear antigen

decreases expression

ISO

Gold analog results in decreased expression of PCNA mRNA

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

phosphodiesterase 4B

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of PDE4B mRNA

NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267

G

period circadian regulator 3

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of PER3 mRNA

NCBI chr 5:166,740,914...166,778,243
Ensembl chr 5:166,743,050...166,777,999

G

phosphatidylinositol glycan anchor biosynthesis, class A

decreases expression

ISO

Gold results in decreased expression of PIGA mRNA

NCBI chr X:33,672,832...33,687,747
Ensembl chr X:33,674,923...33,687,636

G

phosphatidylinositol glycan anchor biosynthesis, class F

decreases expression

ISO

Gold results in decreased expression of PIGF mRNA

NCBI chr 6:13,343,134...13,371,237
Ensembl chr 6:13,342,869...13,393,214

G

phosphatidylinositol glycan anchor biosynthesis, class K

decreases expression

ISO

Gold results in decreased expression of PIGK mRNA

NCBI chr 2:244,289,928...244,375,394
Ensembl chr 2:244,250,621...244,376,030

G

phosphatidylinositol glycan anchor biosynthesis, class Y

decreases expression

ISO

Gold results in decreased expression of PIGY mRNA

NCBI chr 8:28,965,634...28,967,876
Ensembl chr 8:28,965,617...28,968,508

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

pyruvate kinase M1/2

decreases expression

ISO

Gold analog results in decreased expression of PKM protein

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

phospholipase A2 group VI

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of PLA2G6 mRNA

NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:112,731,803...112,771,609

G

pleckstrin homology and FYVE domain containing 2

decreases expression

ISO

Gold results in decreased expression of PLEKHF2 mRNA

NCBI chr 5:28,888,358...28,905,350
Ensembl chr 5:28,868,469...28,923,514

G

perilipin 3

increases expression

ISO

Gold analog results in increased expression of PLIN3 protein

NCBI chr 9:1,198,336...1,210,212
Ensembl chr 9:1,198,336...1,210,231

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

DNA polymerase kappa

decreases expression

ISO

Gold results in decreased expression of POLK mRNA

NCBI chr 2:29,556,831...29,616,960
Ensembl chr 2:29,557,336...29,616,960

G

RNA polymerase II, I and III subunit K

decreases expression

ISO

Gold results in decreased expression of POLR2K mRNA

NCBI chr 7:69,241,233...69,244,579
Ensembl chr 7:69,232,179...69,244,578

G

popeye domain cAMP effector 1

increases expression

ISO

Gold results in increased expression of POPDC1 mRNA

NCBI chr20:50,401,611...50,442,653
Ensembl chr20:50,401,733...50,442,645

G

popeye domain cAMP effector 3

increases expression

ISO

Gold results in increased expression of POPDC3 mRNA

NCBI chr20:50,354,775...50,383,050
Ensembl chr20:50,354,767...50,385,674

G

cytochrome p450 oxidoreductase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of POR mRNA

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

protein phosphatase 1 catalytic subunit beta

decreases expression

ISO

Gold results in decreased expression of PPP1CB mRNA

NCBI chr 6:29,681,099...29,712,835
Ensembl chr 6:29,681,100...29,712,924

G

protein phosphatase 2 scaffold subunit A alpha

decreases expression

ISO

Gold analog results in decreased expression of PPP2R1A protein

NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:69,213,038...69,238,242

G

protein phosphatase 2 regulatory subunit B', epsilon

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of PPP2R5E mRNA

NCBI chr 6:99,904,569...100,053,672
Ensembl chr 6:99,904,569...100,053,573

G

peroxiredoxin 1

decreases expression
increases expression

ISO

Gold analog results in decreased expression of PRDX1 protein
Gold analog results in increased expression of PRDX1 mRNA

PMID:24780912 PMID:36057382

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

proline-rich coiled-coil 2A

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of PRRC2A mRNA

NCBI chr20:3,660,981...3,686,715
Ensembl chr20:3,663,400...3,678,778

G

phosphoserine aminotransferase 1

decreases expression

ISO

Gold analog results in decreased expression of PSAT1 protein

NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693

G

proteasome 26S subunit, non-ATPase 14

decreases expression

ISO

Gold results in decreased expression of PSMD14 mRNA

NCBI chr 3:66,662,933...66,755,666
Ensembl chr 3:66,662,900...66,755,665

G

polypyrimidine tract binding protein 2

decreases expression

ISO

Gold results in decreased expression of PTBP2 mRNA

NCBI chr 2:210,497,610...210,558,497
Ensembl chr 2:210,497,706...210,558,291

G

prostaglandin reductase 1

increases expression

ISO

Gold results in increased expression of PTGR1 mRNA

NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811

G

prostaglandin reductase 2

decreases expression

ISO

Gold results in decreased expression of PTGR2 mRNA

NCBI chr 6:109,662,469...109,694,232
Ensembl chr 6:109,662,498...109,694,232

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

ISO

[Gold co-treated with Silicon Dioxide] results in increased expression of PTGS2 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of PTGS2 mRNA
Gold results in increased expression of PTGS2 mRNA

PMID:22155353 PMID:28433809

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine phosphatase, receptor type, C

increases expression

ISO

Gold analog results in increased expression of PTPRC mRNA

NCBI chr13:52,147,717...52,259,810
Ensembl chr13:52,147,717...52,259,746

G

6-pyruvoyl-tetrahydropterin synthase

decreases expression

ISO

Gold results in decreased expression of PTS mRNA

NCBI chr 8:59,767,234...59,774,265
Ensembl chr 8:59,765,185...59,774,265

G

PVR cell adhesion molecule

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of PVR mRNA

NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:88,688,981...88,704,630

G

RAB11a, member RAS oncogene family

decreases expression

ISO

Gold results in decreased expression of RAB11A mRNA

NCBI chr 8:74,118,922...74,141,760
Ensembl chr 8:74,118,922...74,141,837

G

RAB18, member RAS oncogene family

decreases expression

ISO

Gold results in decreased expression of RAB18 mRNA

NCBI chr17:59,639,264...59,670,653
Ensembl chr17:59,639,203...59,672,806

G

Rab geranylgeranyltransferase subunit beta

decreases expression

ISO

Gold results in decreased expression of RABGGTB mRNA

NCBI chr 2:245,504,586...245,510,878
Ensembl chr 2:245,504,586...245,510,774

G

RAD51 recombinase

decreases expression

ISO

Gold analog results in decreased expression of RAD51 mRNA

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:126,554,190...126,579,469

G

RAD51 paralog B

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RAD51B mRNA

NCBI chr 6:103,829,390...104,373,923
Ensembl chr 6:103,829,554...104,374,509

G

retinoic acid induced 14

increases expression

ISO

Gold results in increased expression of RAI14 mRNA

NCBI chr 2:61,273,439...61,411,141
Ensembl chr 2:61,273,439...61,409,791

G

RB1-inducible coiled-coil 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RB1CC1 mRNA

NCBI chr 5:17,948,522...18,012,434
Ensembl chr 5:17,948,522...18,012,434

G

RNA binding motif protein 12

decreases expression

ISO

Gold results in decreased expression of RBM12 mRNA

NCBI chr 3:165,069,744...165,089,994
Ensembl chr 3:165,042,878...165,090,021

G

retinol binding protein 1

increases expression

ISO

Gold results in increased expression of RBP1 mRNA

NCBI chr 8:107,904,589...107,926,109
Ensembl chr 8:107,887,417...107,983,847

G

ring finger and CCCH-type domains 1

decreases expression

ISO

Gold results in decreased expression of RC3H1 mRNA

NCBI chr13:75,707,098...75,779,114
Ensembl chr13:75,707,338...75,772,816

G

radixin

decreases expression

ISO

Gold analog results in decreased expression of RDX mRNA

NCBI chr 8:61,275,792...61,348,260
Ensembl chr 8:61,274,460...61,333,967

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

riboflavin kinase

decreases expression

ISO

Gold results in decreased expression of RFK mRNA

NCBI chr 1:224,226,632...224,234,185
Ensembl chr 1:224,226,628...224,235,698
Ensembl chr X:224,226,628...224,235,698

G

ras homolog family member U

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RHOU mRNA

NCBI chr19:68,538,960...68,548,733
Ensembl chr19:68,538,960...68,548,733

G

ring finger protein 11

decreases expression

ISO

Gold results in decreased expression of RNF11 mRNA

NCBI chr 5:129,441,071...129,471,799
Ensembl chr 5:129,442,309...129,463,538

G

ring finger protein 13

decreases expression

ISO

Gold results in decreased expression of RNF13 mRNA

NCBI chr 2:144,076,526...144,211,520
Ensembl chr 2:144,077,916...144,211,798

G

ring finger protein 138

decreases expression

ISO

Gold results in decreased expression of RNF138 mRNA

NCBI chr18:12,558,430...12,590,849
Ensembl chr18:12,566,502...12,590,848

G

ring finger protein 149

decreases expression

ISO

Gold results in decreased expression of RNF149 mRNA

NCBI chr 9:49,322,524...49,350,361
Ensembl chr 9:49,323,857...49,350,042

G

ring finger protein 2

decreases expression

ISO

Gold results in decreased expression of RNF2 mRNA

NCBI chr13:66,103,943...66,136,038
Ensembl chr13:66,083,653...66,133,161

G

ring finger protein, transmembrane 1

decreases expression

ISO

Gold results in decreased expression of RNFT1 mRNA

NCBI chr10:71,807,403...71,821,132
Ensembl chr10:71,807,456...71,821,141

G

Ro60, Y RNA binding protein

decreases expression

ISO

Gold results in decreased expression of RO60 mRNA

NCBI chr13:58,049,838...58,070,828
Ensembl chr13:58,049,858...58,076,264

G

RP2 activator of ARL3 GTPase

decreases expression

ISO

Gold results in decreased expression of RP2 mRNA

NCBI chr X:4,426,071...4,470,200
Ensembl chr X:4,403,052...4,530,576

G

ribosomal protein S27-like

decreases expression

ISO

Gold results in decreased expression of RPS27L mRNA

NCBI chr 8:76,443,658...76,448,593
Ensembl chr12:33,713,661...33,714,130
Ensembl chr 8:33,713,661...33,714,130

G

ribosomal protein S6 kinase B1

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in decreased expression of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

RT1 class II, locus Db1

increases expression

ISO

Gold analog results in increased expression of HLA-DRB1 mRNA

NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165

G

reticulon 4

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of RTN4 mRNA

NCBI chr14:107,651,001...107,698,610
Ensembl chr14:107,650,732...107,698,611

G

secretion associated, Ras related GTPase 1B

decreases expression

ISO

Gold results in decreased expression of SAR1B mRNA

NCBI chr10:36,525,365...36,555,009
Ensembl chr10:36,519,384...36,555,005

G

SAP domain containing ribonucleoprotein

decreases expression

ISO

Gold results in decreased expression of SARNP mRNA

NCBI chr 7:1,835,597...1,889,833
Ensembl chr 7:1,835,597...1,897,295

G

short coiled-coil protein

decreases expression

ISO

Gold results in decreased expression of SCOC mRNA

NCBI chr19:41,564,166...41,593,932
Ensembl chr19:41,564,112...41,597,912

G

sterol carrier protein 2

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of SCP2 mRNA

NCBI chr 5:128,035,714...128,110,015
Ensembl chr 5:128,008,125...128,110,043

G

Sec23 homolog A, COPII coat complex component

decreases expression

ISO

Gold results in decreased expression of SEC23A mRNA

NCBI chr 6:82,393,699...82,442,594
Ensembl chr 6:82,394,863...82,440,904

G

SEC24 homolog A, COPII coat complex component

decreases expression

ISO

Gold results in decreased expression of SEC24A mRNA

NCBI chr10:36,450,043...36,525,303
Ensembl chr10:36,450,043...36,525,303

G

SEL1L family member 3

increases expression

ISO

Gold results in increased expression of SEL1L3 mRNA

NCBI chr14:61,988,350...62,095,542
Ensembl chr14:61,988,346...62,095,542

G

selenoprotein T

decreases expression

ISO

Gold results in decreased expression of SELENOT mRNA

NCBI chr 2:144,954,324...144,971,375
Ensembl chr 2:144,954,312...144,971,369

G

septin 8

decreases expression

ISO

Gold analog results in decreased expression of SEPTIN8 protein

NCBI chr10:38,185,454...38,214,502
Ensembl chr10:38,185,335...38,214,504

G

stress-associated endoplasmic reticulum protein 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of SERP1 mRNA

NCBI chr 2:144,907,204...144,911,187
Ensembl chr 2:144,907,205...144,911,187

G

serpin family E member 1

increases expression

ISO

Gold results in increased expression of SERPINE1 mRNA

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

serpin family H member 1

decreases expression

ISO

Gold analog results in decreased expression of SERPINH1 protein

NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:163,055,630...163,062,976

G

SH3 domain-containing kinase-binding protein 1

increases expression

ISO

Gold results in increased expression of SH3KBP1 mRNA

NCBI chr X:38,686,530...39,031,658
Ensembl chr X:38,686,530...39,031,393

G

solute carrier family 25 member 24

decreases expression

ISO

Gold analog results in decreased expression of SLC25A24 protein

NCBI chr 2:199,449,425...199,487,287
Ensembl chr 2:199,449,345...199,487,290

G

SRA stem-loop interacting RNA binding protein

decreases expression

ISO

Gold results in decreased expression of SLIRP mRNA

NCBI chr 6:112,819,684...112,828,715
Ensembl chr 6:112,819,448...112,828,715

G

SNF2 related chromatin remodeling ATPase with DExD box 1

decreases expression

ISO

Gold results in decreased expression of SMARCAD1 mRNA

NCBI chr 4:95,639,722...95,709,055
Ensembl chr 4:95,641,295...95,702,414

G

structural maintenance of chromosomes 4

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SMC4 mRNA

NCBI chr 2:155,550,262...155,578,695
Ensembl chr 2:155,550,262...155,581,937

G

structural maintenance of chromosomes 6

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SMC6 mRNA

NCBI chr 6:39,697,810...39,752,275
Ensembl chr 6:39,697,811...39,752,279

G

small nuclear ribonucleoprotein polypeptide B2

decreases expression

ISO

Gold results in decreased expression of SNRPB2 mRNA

NCBI chr 3:150,852,814...150,862,364
Ensembl chr 3:150,852,790...150,863,428

G

sorting nexin 6

decreases expression

ISO

Gold results in decreased expression of SNX6 mRNA

NCBI chr 6:77,966,141...78,009,343
Ensembl chr 6:77,965,819...78,051,290

G

superoxide dismutase 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

SP100 nuclear antigen

decreases expression

ISO

Gold results in decreased expression of SP100 mRNA

NCBI chr 9:93,758,975...93,825,068
Ensembl chr 9:93,759,075...93,825,068

G

Sp3 transcription factor

decreases expression

ISO

Gold results in decreased expression of SP3 mRNA

NCBI chr 3:78,219,421...78,272,318
Ensembl chr 3:78,219,426...78,264,517

G

spastin

decreases expression

ISO

Gold results in decreased expression of SPAST mRNA

NCBI chr 6:26,807,220...26,858,456
Ensembl chr 6:26,807,220...26,858,446

G

spermatogenesis associated 2

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of SPATA2 mRNA

NCBI chr 3:176,621,974...176,639,784
Ensembl chr 3:176,622,350...176,632,013

G

sterol regulatory element binding transcription factor 1

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of SREBF1 mRNA
Gold analog results in decreased expression of SREBF1 mRNA

PMID:28433809 PMID:36057382

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

SREK1-interacting protein 1

decreases expression

ISO

Gold results in decreased expression of SREK1IP1 mRNA

NCBI chr 2:37,709,712...37,733,391
Ensembl chr 2:37,709,768...37,733,383
Ensembl chr 7:37,709,768...37,733,383

G

signal recognition particle 9

decreases expression

ISO

Gold results in decreased expression of SRP9 mRNA

NCBI chr13:96,364,253...96,372,393
Ensembl chr13:96,364,298...96,373,257

G

serine and arginine rich splicing factor 10

decreases expression

ISO

Gold results in decreased expression of SRSF10 mRNA

NCBI chr 5:153,372,307...153,386,520
Ensembl chr 5:153,372,316...153,386,513

G

serine and arginine rich splicing factor 3

decreases expression

ISO

Gold results in decreased expression of SRSF3 mRNA

NCBI chr20:7,093,529...7,103,517
Ensembl chr20:7,093,565...7,103,516

G

serine and arginine rich splicing factor 7

decreases expression

ISO

Gold results in decreased expression of SRSF7 mRNA

NCBI chr 6:20,564,035...20,571,205
Ensembl chr 6:20,564,044...20,571,212

G

signal transducer and activator of transcription 1

multiple interactions
increases expression

ISO

[Gold co-treated with Silicon Dioxide] results in increased expression of STAT1 mRNA
Gold results in increased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

increases expression
multiple interactions

ISO

Gold results in increased expression of STAT3 mRNA
[Gold co-treated with Silicon Dioxide] results in increased expression of STAT3 mRNA

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

staufen double-stranded RNA binding protein 2

decreases expression

ISO

Gold results in decreased expression of STAU2 mRNA

NCBI chr 5:7,623,528...7,868,206
Ensembl chr 5:7,624,019...7,868,204

G

starch binding domain 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of STBD1 mRNA

NCBI chr14:15,754,769...15,758,174
Ensembl chr14:15,754,644...15,761,659

G

STEAP family member 1

decreases expression

ISO

Gold results in decreased expression of STEAP1 mRNA

NCBI chr 4:29,231,809...29,242,317
Ensembl chr 4:29,231,753...29,242,317

G

serine/threonine kinase 26

decreases expression

ISO

Gold results in decreased expression of STK26 mRNA

NCBI chr X:135,195,176...135,259,994
Ensembl chr X:135,195,204...135,259,993

G

succinate-CoA ligase ADP-forming subunit beta

decreases expression

ISO

Gold analog results in decreased expression of SUCLA2 mRNA; Gold results in decreased expression of SUCLA2 mRNA

PMID:25523186 PMID:36057382

NCBI chr15:55,161,894...55,215,031
Ensembl chr15:55,161,868...55,215,029

G

synaptotagmin 1

decreases expression

ISO

Gold analog results in decreased expression of SYT1 mRNA

NCBI chr 7:45,699,649...46,244,460
Ensembl chr 7:45,702,228...46,244,213

G

synoviolin 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of SYVN1 mRNA

NCBI chr 1:212,766,736...212,775,426
Ensembl chr 1:212,768,907...212,776,457

G

tumor-associated calcium signal transducer 2

increases expression

ISO

Gold results in increased expression of TACSTD2 mRNA

NCBI chr 4:98,037,620...98,039,320
Ensembl chr 4:98,033,251...98,039,323

G

transcriptional adaptor 1

decreases expression

ISO

Gold results in decreased expression of TADA1 mRNA

NCBI chr13:81,165,871...81,180,421
Ensembl chr13:81,165,850...81,188,495

G

TATA-box binding protein associated factor 9b

decreases expression

ISO

Gold results in decreased expression of TAF9B mRNA

NCBI chr X:75,354,823...75,366,166
Ensembl chr X:75,354,825...75,366,414

G

transgelin

decreases expression

ISO

Gold analog results in decreased expression of TAGLN mRNA

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563

G

TBL1X/Y related 1

decreases expression

ISO

Gold results in decreased expression of TBL1XR1 mRNA

NCBI chr 2:106,718,811...106,857,989
Ensembl chr 2:106,730,665...106,857,989

G

transcription elongation factor A1

decreases expression

ISO

Gold results in decreased expression of TCEA1 mRNA

NCBI chr 5:19,414,351...19,466,629
Ensembl chr15:12,831,339...12,834,156
Ensembl chr 5:12,831,339...12,834,156

G

tryptophan 2,3-dioxygenase

decreases expression

ISO

Gold results in decreased expression of TDO2 mRNA

NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586

G

testis expressed 30

decreases expression

ISO

Gold results in decreased expression of TEX30 mRNA

NCBI chr 9:53,735,512...53,744,672
Ensembl chr 9:53,735,512...53,741,042

G

transcription factor EC

decreases expression

ISO

Gold results in decreased expression of TFEC mRNA

NCBI chr 4:46,072,093...46,146,200
Ensembl chr 4:46,073,605...46,146,200

G

tissue factor pathway inhibitor 2

increases expression

ISO

Gold results in increased expression of TFPI2 mRNA

NCBI chr 4:32,936,462...32,941,385
Ensembl chr 4:32,936,854...32,941,426

G

transforming growth factor, beta 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

THAP domain containing 1

decreases expression

ISO

Gold results in decreased expression of THAP1 mRNA

NCBI chr16:72,608,096...72,612,690
Ensembl chr16:72,607,305...72,612,690

G

TIA1 cytotoxic granule-associated RNA binding protein

decreases expression

ISO

Gold results in decreased expression of TIA1 mRNA

NCBI chr 4:120,410,180...120,440,676
Ensembl chr 4:120,410,251...120,440,665

G

transketolase

decreases expression

ISO

Gold analog results in decreased expression of TKT protein

NCBI chr16:5,729,381...5,755,170
Ensembl chr16:5,729,991...5,756,431

G

tousled-like kinase 1

increases expression

ISO

Gold results in increased expression of TLK1 mRNA

NCBI chr 3:75,928,303...76,035,246
Ensembl chr 3:75,928,303...76,035,059

G

toll-like receptor 2

increases expression
multiple interactions

ISO

Gold results in increased expression of TLR2 mRNA
Gold promotes the reaction [SAA1 protein binds to TLR2 protein]

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

transmembrane 4 L six family member 1

increases expression

ISO

Gold results in increased expression of TM4SF1 mRNA

NCBI chr 2:143,606,980...143,616,176
Ensembl chr 2:143,603,271...143,616,176

G

transmembrane p24 trafficking protein 10

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of TMED10 mRNA

NCBI chr 6:110,722,887...110,757,743
Ensembl chr 6:110,722,889...110,757,777

G

tumor necrosis factor

increases secretion
multiple interactions

ISO

Gold results in increased secretion of TNF protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF alpha induced protein 8 like 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFAIP8L1 mRNA

NCBI chr 9:1,075,724...1,088,256
Ensembl chr 9:1,055,801...1,092,803

G

TNF receptor superfamily member 10b

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF10A mRNA

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082

G

TNF receptor superfamily member 1A

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF superfamily member 10

decreases expression

ISO

Gold analog results in decreased expression of TNFSF10 mRNA

NCBI chr 2:112,136,550...112,155,903

G

tumor protein p53

increases expression

ISO

Gold analog results in increased expression of TRP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein, translationally-controlled 1

decreases expression

ISO

Gold analog results in decreased expression of TPT1 protein

NCBI chr15:57,562,217...57,568,968
Ensembl chr15:57,566,067...57,569,554

G

tripartite motif-containing 23

decreases expression

ISO

Gold results in decreased expression of TRIM23 mRNA

NCBI chr 2:37,036,193...37,069,024
Ensembl chr 2:37,035,477...37,069,526

G

tRNA methyltransferase 13 homolog

decreases expression

ISO

Gold results in decreased expression of TRMT13 mRNA

NCBI chr 2:207,217,399...207,232,467
Ensembl chr 2:207,218,552...207,231,701

G

TruB pseudouridine synthase family member 1

decreases expression

ISO

Gold results in decreased expression of TRUB1 mRNA

NCBI chr 1:266,518,510...266,559,633
Ensembl chr 1:266,520,637...266,581,178

G

tubulin, alpha 1A

decreases expression

ISO

Gold analog results in decreased expression of TUBA1A protein

NCBI chr 7:131,992,151...131,996,850
Ensembl chr 7:131,968,770...131,996,035

G

tubulin, beta 5 class I

decreases expression

ISO

Gold analog results in decreased expression of TUBB5 protein

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726

G

Tu translation elongation factor, mitochondrial

multiple interactions

ISO

Gold analog results in decreased expression of and results in increased phosphorylation of TUFM protein

NCBI chr 1:190,504,373...190,507,980
Ensembl chr 1:190,504,373...190,508,952

G

thioredoxin domain containing 5

multiple interactions

ISO

Gold analog results in decreased expression of and results in increased phosphorylation of TXNDC5 protein

NCBI chr17:26,495,467...26,523,608
Ensembl chr17:26,490,047...26,523,597

G

thioredoxin interacting protein

decreases expression

ISO

Gold analog results in decreased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

thioredoxin reductase 1

decreases activity
increases expression

EXP
ISO

Gold results in decreased activity of TXNRD1 protein
Gold results in increased expression of TXNRD1 mRNA

PMID:16510263 PMID:20851179 PMID:29705079

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

thioredoxin reductase 2

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of TXNRD2 mRNA

NCBI chr11:96,024,321...96,072,475
Ensembl chr11:96,024,324...96,072,475

G

UDP-N-acetylglucosamine pyrophosphorylase 1 like 1

decreases expression

ISO

Gold analog results in decreased expression of UAP1L1 protein

NCBI chr 3:28,570,854...28,579,766
Ensembl chr 3:28,573,358...28,578,630

G

ubiquitin-like modifier activating enzyme 2

decreases expression

ISO

Gold results in decreased expression of UBA2 mRNA

NCBI chr 1:95,912,422...95,939,870
Ensembl chr 1:95,912,430...95,939,901

G

ubiquitin-conjugating enzyme E2G 2

decreases expression

ISO

Gold analog results in decreased expression of UBE2G2 mRNA

NCBI chr20:10,983,322...11,005,060
Ensembl chr20:10,983,325...11,005,187

G

ubiquitin-conjugating enzyme E2H

increases expression

ISO

Gold results in increased expression of UBE2H mRNA

NCBI chr 4:59,802,102...59,897,583
Ensembl chr 4:59,802,102...59,897,583

G

ubiquitin-conjugating enzyme E2N

decreases expression

ISO

Gold results in decreased expression of UBE2N mRNA

NCBI chr 7:32,041,190...32,071,252

G

ubiquitin-conjugating enzyme E2W

decreases expression

ISO

Gold results in decreased expression of UBE2W mRNA

NCBI chr 5:7,474,039...7,531,526
Ensembl chr 5:7,474,003...7,598,245

G

uncoupling protein 2

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of UCP2 mRNA

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743

G

UDP glucuronosyltransferase family 1 member A1

decreases expression

ISO

Gold analog results in decreased expression of UGT1A1 mRNA

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 2 member A1

decreases expression

ISO

Gold analog results in decreased expression of UGT2A1 mRNA

NCBI chr14:20,797,262...20,825,111
Ensembl chr14:20,800,263...20,825,111

G

ubiquitin interaction motif containing 1

increases expression
decreases expression

ISO

Gold results in increased expression of UIMC1 mRNA
Gold results in decreased expression of UIMC1 mRNA

NCBI chr17:9,528,923...9,597,967
Ensembl chr17:9,528,950...9,597,963

G

uridine phosphorylase 2

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of UPP2 mRNA

NCBI chr 3:63,681,671...63,726,194
Ensembl chr 3:63,681,826...63,726,191

G

ubiquitin specific peptidase 1

decreases expression

ISO

Gold results in decreased expression of USP1 mRNA

NCBI chr 5:118,703,056...118,714,426
Ensembl chr 5:118,702,868...118,714,434

G

ubiquitin specific peptidase 15

decreases expression

ISO

Gold results in decreased expression of USP15 mRNA

NCBI chr 7:60,643,611...60,805,137
Ensembl chr 7:60,643,613...60,734,099

G

ubiquitin specific peptidase 16

decreases expression

ISO

Gold results in decreased expression of USP16 mRNA

NCBI chr11:40,166,651...40,196,792
Ensembl chr11:40,167,692...40,196,823

G

ubiquitin specific peptidase 33

decreases expression

ISO

Gold results in decreased expression of USP33 mRNA

NCBI chr 2:243,938,958...243,988,424
Ensembl chr 2:243,943,175...243,988,424

G

ubiquitin specific peptidase 5

decreases expression

ISO

Gold analog results in decreased expression of USP5 protein

NCBI chr 4:159,305,927...159,321,345
Ensembl chr 4:159,305,938...159,320,956

G

vinculin

decreases expression

ISO

Gold analog results in decreased expression of VCL protein

NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,315,069...3,405,163

G

vimentin

increases degradation

ISO

Gold analog results in increased degradation of VIM protein

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

WW domain binding protein 4

decreases expression

ISO

Gold results in decreased expression of WBP4 mRNA

NCBI chr15:61,271,774...61,299,740
Ensembl chr15:61,271,783...61,299,740

G

WEE1 G2 checkpoint kinase

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of WEE1 mRNA

NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449

G

XPA, DNA damage recognition and repair factor

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of XPA mRNA

NCBI chr 5:65,227,281...65,275,784
Ensembl chr 5:65,227,281...65,272,425

G

XPC complex subunit, DNA damage recognition and repair factor

decreases expression

ISO

Gold analog results in decreased expression of XPC mRNA

NCBI chr 4:125,550,833...125,578,084
Ensembl chr 4:125,550,833...125,578,305

G

X-ray repair cross complementing 5

decreases expression

ISO

Gold analog results in decreased expression of XRCC5 mRNA

NCBI chr 9:81,404,507...81,493,293
Ensembl chr 9:81,375,863...81,493,293

G

YOD1 deubiquitinase

decreases expression

ISO

Gold results in decreased expression of YOD1 mRNA

NCBI chr13:44,727,319...44,733,933

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of YWHAG mRNA

NCBI chr12:26,381,106...26,409,466
Ensembl chr12:26,380,816...26,409,465

G

zinc finger and BTB domain containing 21

decreases expression

ISO

Gold results in decreased expression of ZBTB21 mRNA

NCBI chr11:50,781,697...50,796,399
Ensembl chr11:50,781,099...50,796,560

G

zinc finger and BTB domain containing 41

decreases expression

ISO

Gold results in decreased expression of ZBTB41 mRNA

NCBI chr13:53,591,961...53,622,007
Ensembl chr13:53,592,797...53,617,780

G

zinc finger CCCH-type containing 15

decreases expression

ISO

Gold results in decreased expression of ZC3H15 mRNA

NCBI chr 3:89,151,432...89,171,203
Ensembl chr 3:89,151,509...89,171,202

G

zinc finger CCHC-type containing 10

decreases expression

ISO

Gold results in decreased expression of ZCCHC10 mRNA

NCBI chr10:37,971,459...37,981,860
Ensembl chr10:37,969,340...37,981,992

G

zinc finger CCHC-type containing 9

decreases expression

ISO

Gold results in decreased expression of ZCCHC9 mRNA

NCBI chr 2:24,773,319...24,783,339
Ensembl chr 2:24,773,319...24,781,999

G

zinc finger CCHC-type and RNA binding motif containing 1

decreases expression

ISO

Gold results in decreased expression of ZCRB1 mRNA

NCBI chr 7:126,404,675...126,418,012
Ensembl chr 7:126,404,193...126,418,012

G

zinc finger DHHC-type palmitoyltransferase 17

decreases expression

ISO

Gold results in decreased expression of ZDHHC17 mRNA

NCBI chr 7:48,256,269...48,320,000
Ensembl chr 7:48,257,856...48,320,160

G

zinc finger DHHC-type palmitoyltransferase 20

decreases expression

ISO

Gold results in decreased expression of ZDHHC20 mRNA

NCBI chr15:36,095,624...36,154,546
Ensembl chr15:36,098,282...36,154,532

G

zinc finger AN1-type containing 1

decreases expression

ISO

Gold results in decreased expression of ZFAND1 mRNA

NCBI chr 2:93,351,918...93,364,959
Ensembl chr 2:93,351,917...93,360,665

G

zinc finger AN1-type containing 6

decreases expression

ISO

Gold results in decreased expression of ZFAND6 mRNA

NCBI chr 1:147,990,099...148,061,221
Ensembl chr 1:147,990,108...148,061,134

G

zinc finger protein 277

decreases expression

ISO

Gold results in decreased expression of ZNF277 mRNA

NCBI chr 6:63,110,609...63,239,941
Ensembl chr 6:63,110,609...63,239,831

G

zinc finger protein 422

decreases expression

ISO

Gold results in decreased expression of ZNF22 mRNA

NCBI chr 4:151,558,254...151,565,730
Ensembl chr 4:151,556,738...151,566,152

G

zinc finger FYVE-type containing 16

decreases expression

ISO

Gold results in decreased expression of ZFYVE16 mRNA

NCBI chr 2:25,448,264...25,495,180
Ensembl chr 2:25,448,829...25,483,295

G

zinc metallopeptidase STE24

decreases expression

ISO

Gold results in decreased expression of ZMPSTE24 mRNA

NCBI chr 5:139,912,395...139,945,532
Ensembl chr 5:139,913,671...139,945,532

G

zinc finger RANBP2-type containing 2

decreases expression

ISO

Gold results in decreased expression of ZRANB2 mRNA

NCBI chr 2:249,232,010...249,245,786
Ensembl chr 2:249,232,010...249,245,780

G

zinc finger containing ubiquitin peptidase 1

decreases expression

ISO

Gold results in decreased expression of ZUP1 mRNA

NCBI chr20:31,327,939...31,358,088
Ensembl chr20:31,327,940...31,358,023

sodium aurothiomalate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

atypical chemokine receptor 3

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of ACKR3 mRNA

NCBI chr 9:98,247,300...98,258,877
Ensembl chr 9:98,246,605...98,260,214

G

adenosine A2a receptor

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of ADORA2A mRNA

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802

G

adhesion molecule with Ig like domain 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of AMIGO2 mRNA

NCBI chr 7:130,270,639...130,273,735
Ensembl chr 7:130,270,554...130,282,218

G

ANTXR cell adhesion molecule 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of ANTXR1 mRNA

NCBI chr 4:121,148,102...121,335,549
Ensembl chr 4:121,148,103...121,336,892

G

aldehyde oxidase 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of AOX1 mRNA

NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980

G

BCL2-related protein A1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of BCL2A1 mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

bone marrow stromal cell antigen 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of BST2 mRNA

NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967

G

C-C motif chemokine ligand 20

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of CCL20 mRNA; Gold Sodium Thiomalate results in decreased expression of CCL20 protein

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

cellular communication network factor 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of CCN1 mRNA

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

cellular communication network factor 5

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of CCN5 mRNA

NCBI chr 3:172,910,670...172,922,064
Ensembl chr 3:172,910,681...172,922,062

G

Cd28 molecule

multiple interactions
affects response to substance

ISO

CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
CD28 protein affects the susceptibility to Gold Sodium Thiomalate

NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:69,545,326...69,689,192

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

calmegin

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of CLGN mRNA

NCBI chr19:41,601,568...41,633,207
Ensembl chr19:41,601,568...41,633,325

G

collagen type I alpha 1 chain

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collectin sub-family member 12

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of COLEC12 mRNA

NCBI chr18:1,005,787...1,193,455
Ensembl chr18:1,005,741...1,195,297

G

C-X-C motif chemokine ligand 1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of CXCL2 mRNA

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine ligand 3

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of CXCL1 mRNA

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine receptor 4

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of CXCR4 mRNA

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

DEAD-box helicase 10

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of DDX10 mRNA

NCBI chr 8:62,384,876...62,539,585
Ensembl chr 8:62,384,876...62,539,585

G

iodothyronine deiodinase 1

decreases activity

ISO

Gold Sodium Thiomalate results in decreased activity of DIO1 protein

NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771

G

EGF containing fibulin extracellular matrix protein 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of EFEMP1 mRNA

NCBI chr14:106,811,769...106,890,961
Ensembl chr14:106,802,304...106,892,808

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of ENPP2 mRNA

NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957

G

ectonucleoside triphosphate diphosphohydrolase 3

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of ENTPD3 mRNA

NCBI chr 8:129,124,540...129,155,528
Ensembl chr 8:129,124,709...129,156,252

G

fibrillarin

affects localization
multiple interactions
decreases activity

ISO

Gold Sodium Thiomalate affects the localization of FBL protein
CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]

PMID:10942594 PMID:19077085

NCBI chr 1:92,597,407...92,606,507
Ensembl chr 1:92,597,258...92,606,506

G

fibulin 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of FBLN1 mRNA

NCBI chr 7:118,190,347...118,269,965
Ensembl chr 7:118,190,478...118,269,965

G

fibroblast growth factor 7

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of FGF7 mRNA

NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:133,734,673...133,786,328

G

guanylate binding protein 1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of GBP1 mRNA

NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:234,190,708...234,206,802
Ensembl chr 2:234,190,708...234,206,802

G

glycoprotein m6b

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of GPM6B mRNA

NCBI chr X:31,689,485...31,836,199
Ensembl chr X:31,690,359...31,733,272

G

gasdermin E

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of GSDME mRNA

NCBI chr 4:80,590,344...80,651,943
Ensembl chr 4:80,588,614...80,641,525

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of HERC6 mRNA

NCBI chr 4:88,854,612...88,897,043
Ensembl chr 4:88,854,640...88,896,993

G

hypoxia inducible lipid droplet-associated

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of HILPDA mRNA

NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:58,836,463...58,839,423

G

hydroxysteroid 11-beta dehydrogenase 1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of HSD11B1 mRNA

NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432

G

interferon, alpha-inducible protein 27

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IFI27 mRNA

NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:128,355,079...128,361,781

G

interferon-induced protein 35

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IFI35 mRNA

NCBI chr10:86,881,270...86,889,523
Ensembl chr10:86,887,122...86,889,750

G

interferon-induced protein 44

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IFI44 mRNA

NCBI chr 2:243,286,050...243,303,869
Ensembl chr 2:243,286,052...243,306,877

G

interferon-induced protein 44-like

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IFI44L mRNA

NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:243,328,723...243,366,404

G

interferon induced with helicase C domain 1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IFIH1 mRNA

NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:67,637,545...67,683,968

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IFIT3 mRNA

NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:241,526,880...241,532,521

G

interferon gamma

multiple interactions
affects response to substance

ISO

IFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IFNG protein affects the susceptibility to Gold Sodium Thiomalate

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 10

multiple interactions

ISO

[Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Gold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES]

PMID:16393772 PMID:25314295

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor antagonist

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IL1RN mRNA

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732

G

interleukin 23 subunit alpha

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IL23A mRNA

NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434

G

interleukin 4

multiple interactions
affects response to substance

ISO

IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IL4 protein affects the susceptibility to Gold Sodium Thiomalate

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions
affects response to substance
decreases expression

ISO

[Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL6 protein
IL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IL6 protein affects the susceptibility to Gold Sodium Thiomalate
Gold Sodium Thiomalate results in decreased expression of IL6 mRNA; Gold Sodium Thiomalate results in decreased expression of IL6 protein

PMID:11824965 PMID:19077085 PMID:19192274

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interferon regulatory factor 7

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of IRF7 mRNA

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023

G

ISG15 ubiquitin-like modifier

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of ISG15 mRNA

NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656

G

interferon stimulated exonuclease gene 20

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of ISG20 mRNA

NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401

G

laminin subunit beta 3

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of LAMB3 mRNA

NCBI chr13:107,362,514...107,404,081
Ensembl chr13:107,322,526...107,404,081

G

latexin

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of LXN mRNA

NCBI chr 2:154,037,604...154,043,473
Ensembl chr 2:154,037,292...154,043,488

G

lymphocyte antigen 6 family member E

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of LY6E mRNA

NCBI chr 7:108,815,970...108,820,444
Ensembl chr 7:108,816,887...108,820,443

G

myristoylated alanine rich protein kinase C substrate

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of MARCKS mRNA

NCBI chr20:42,240,185...42,245,882
Ensembl chr20:42,240,185...42,245,882

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

microRNA 99b

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased expression of MIR99B mRNA]

NCBI chr 1:67,350,064...67,350,133
Ensembl chr 1:67,350,060...67,350,139

G

matrix metallopeptidase 10

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of MMP10 mRNA

NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:12,974,707...12,982,613

G

MX dynamin like GTPase 1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of MX1 mRNA

NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904

G

NDUFA4, mitochondrial complex associated like 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of NDUFA4L2 mRNA

NCBI chr 7:65,242,169...65,244,296
Ensembl chr 7:65,242,135...65,244,277

G

neuromedin B

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of NMB mRNA

NCBI chr 1:144,278,678...144,290,523
Ensembl chr 1:144,278,453...144,281,422

G

nitric oxide synthase 2

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nuclear receptor subfamily 4, group A, member 3

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

2'-5' oligoadenylate synthetase 1A

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of OAS1 mRNA

NCBI chr12:41,330,423...41,341,130
Ensembl chr12:41,285,211...41,341,128

G

2'-5'-oligoadenylate synthetase-like

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of OASL mRNA

NCBI chr12:47,343,551...47,356,509
Ensembl chr12:47,343,551...47,356,483

G

olfactomedin-like 2B

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of OLFML2B mRNA

NCBI chr13:85,402,151...85,439,342
Ensembl chr13:85,402,169...85,439,342

G

phosphoglycerate dehydrogenase

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of PHGDH mRNA

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789

G

phospholipid phosphatase 3

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of PLPP3 mRNA

NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:125,155,945...125,235,667

G

protein phosphatase 4, regulatory subunit 2

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of PPP4R2 mRNA

NCBI chr 4:135,010,919...135,051,844
Ensembl chr 4:135,010,919...135,051,844

G

prostaglandin E synthase

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES]

NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

retinoic acid receptor responder 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of RARRES1 mRNA

NCBI chr 2:154,059,761...154,094,021
Ensembl chr 2:154,059,761...154,094,024

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

regulator of G-protein signaling 4

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of RGS4 mRNA

NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884

G

RNA sensor RIG-1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of RIGI mRNA

NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:60,117,398...60,165,995

G

receptor-interacting serine-threonine kinase 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of RIPK2 mRNA

NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663

G

ring finger protein 19B

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of RNF19B mRNA

NCBI chr 5:146,690,453...146,715,729
Ensembl chr 5:146,690,577...146,714,394

G

radical S-adenosyl methionine domain containing 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of RSAD2 mRNA

NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:48,774,985...48,788,320

G

solute carrier family 7 member 11

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

spermine synthase

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of SMS mRNA

NCBI chr X:41,331,693...41,387,713
Ensembl chr X:41,331,799...41,387,712

G

superoxide dismutase 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

spondin 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of SPON1 mRNA

NCBI chr 1:177,363,526...177,662,689
Ensembl chr 1:177,363,197...177,662,676

G

signal transducer and activator of transcription 1

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

steroid sulfatase

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of STS mRNA

NCBI chr X:46,102,524...46,110,868
Ensembl chr X:46,102,548...46,111,104

G

thrombospondin 1

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of THBS1 mRNA

NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402

G

thrombospondin 2

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of THBS2 mRNA

NCBI chr 1:64,343,523...64,372,918
Ensembl chr 1:64,343,523...64,372,918

G

toll-like receptor 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of TLR2 mRNA

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

TNF alpha induced protein 2

decreases expression

ISO

Gold Sodium Thiomalate results in decreased expression of TNFAIP2 mRNA

NCBI chr 6:136,297,388...136,311,106
Ensembl chr 6:136,298,082...136,311,106

G

thioredoxin interacting protein

increases expression

ISO

Gold Sodium Thiomalate results in increased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

thioredoxin reductase 1

multiple interactions
decreases activity

ISO
EXP

Gold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]
Gold Sodium Thiomalate results in decreased activity of TXNRD1 protein

PMID:16510263 PMID:17229725

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

thioredoxin reductase 2

decreases activity

EXP

Gold Sodium Thiomalate results in decreased activity of TXNRD2 protein

NCBI chr11:96,024,321...96,072,475
Ensembl chr11:96,024,324...96,072,475

sodium aurothiosulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

affects binding

ISO

Gold Sodium Thiosulfate binds to ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

CD40 molecule

increases expression

ISO

Gold Sodium Thiosulfate results in increased expression of CD40 protein

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

interleukin 6

increases secretion

ISO

Gold Sodium Thiosulfate results in increased secretion of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

toll-like receptor 3

multiple interactions

ISO

TLR3 protein affects the reaction [Gold Sodium Thiosulfate results in increased secretion of CXCL8 protein]

NCBI chr16:53,554,916...53,572,321
Ensembl chr16:53,555,131...53,568,385

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
chemical entity	20860
molecular entity	20859
transition element molecular entity	17816
copper group molecular entity	9869
gold molecular entity	617
elemental gold +	512
gold coordination entity +	137
gold salt +	0
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
metal atom	18405
transition element atom	17948
d-block element atom	17943
copper group element atom	9869
gold atom	617
gold molecular entity	617
elemental gold +	512
gold coordination entity +	137
gold salt +	0

paths to the root