cobalt coordination entity - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	cobalt coordination entity	go back to main search page
Accession:	CHEBI:33890	browse the term
Synonyms:	related_synonym:	cobalt coordination compounds; cobalt coordination entities

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Rat (111) Mouse (113) Human (109) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (9) Green Monkey (0) Naked Mole-rat (0) All
Genes (109)

cobamamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase pi 1

multiple interactions

cobamamide inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656

cyanocob(III)alamin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

decreases expression
multiple interactions

Vitamin B 12 results in decreased expression of ABCB1 mRNA; Vitamin B 12 results in decreased expression of ABCB1 protein
Vitamin B 12 inhibits the reaction [Methotrexate results in increased expression of ABCB1 mRNA]

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily C member 4 (PEL blood group)

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ABCC4 mRNA

NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475

G

ATP binding cassette subfamily D member 4

affects metabolic processing

ABCD4 protein affects the metabolism of Vitamin B 12

NCBI chr14:74,285,269...74,302,934
Ensembl chr14:74,285,269...74,303,055

G

acetyl-CoA carboxylase alpha

multiple interactions

[Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA

NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836

G

acetyl-CoA carboxylase beta

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ACACB mRNA

NCBI chr12:109,111,189...109,268,226
Ensembl chr12:109,116,587...109,268,226

G

actin alpha 2, smooth muscle

multiple interactions

Vitamin B 12 inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA]

NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339

G

adhesion G protein-coupled receptor G2

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ADGRG2 mRNA

NCBI chr X:18,989,307...19,122,956
Ensembl chr X:18,989,307...19,122,637

G

aldo-keto reductase family 1 member B15

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA

NCBI chr 7:134,549,110...134,579,869
Ensembl chr 7:134,549,110...134,579,875

G

aldehyde dehydrogenase 2 family member

multiple interactions

[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein

NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532

G

arsenite methyltransferase

multiple interactions

Folic Acid promotes the reaction [Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]]; Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]

NCBI chr10:102,869,470...102,901,899
Ensembl chr10:102,869,470...102,901,899

G

axin 1

multiple interactions

[Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene

NCBI chr16:287,440...352,723
Ensembl chr16:287,440...352,723

G

brain derived neurotrophic factor

multiple interactions

Vitamin B 12 inhibits the reaction [Streptozocin results in decreased expression of BDNF protein]

NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058

G

caspase 3

multiple interactions

Folic Acid inhibits the reaction [Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP3 mRNA]]; Vitamin B 12 inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP3 mRNA]

PMID:23935743 PMID:38049026

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

multiple interactions

Folic Acid inhibits the reaction [Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA]]; Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA]

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

catalase

multiple interactions

[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased activity of CAT protein
Vitamin B 12 promotes the reaction [Folic Acid inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]]

PMID:16214333 PMID:20118189

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

cystathionine beta-synthase

multiple interactions

[Fatty Acids, Omega-3 co-treated with Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA; [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA

NCBI chr21:43,053,191...43,076,873
Ensembl chr21:43,053,191...43,076,943

G

C-C motif chemokine ligand 2

multiple interactions

[Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CCL2 mRNA

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

CD40 molecule

multiple interactions

[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of CD40 mRNA

NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863

G

cyclin dependent kinase 1

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CDK1 mRNA

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cardiotrophin like cytokine factor 1

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CLCF1 mRNA

NCBI chr11:67,364,168...67,374,177
Ensembl chr11:67,364,168...67,374,177

G

C-reactive protein

multiple interactions

[Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein; [Vitamin E co-treated with Ascorbic Acid co-treated with Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein

NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589

G

cytochrome P450 family 26 subfamily A member 1

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP26A1 mRNA

NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885

G

cytochrome P450 family 2 subfamily B member 6

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2B10 mRNA

NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398

G

cytochrome P450 family 2 subfamily E member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]

NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220

G

DNA damage inducible transcript 3

multiple interactions

Vitamin B 12 inhibits the reaction [Streptozocin results in increased expression of DDIT3 protein]
[Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of DDIT3 protein]

PMID:37263574 PMID:38049026

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

DEPP autophagy regulator 1

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of DEPP1 mRNA

NCBI chr10:44,976,128...44,978,809
Ensembl chr10:44,970,981...44,978,809

G

E2F transcription factor 8

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of E2F8 mRNA

NCBI chr11:19,224,063...19,241,655
Ensembl chr11:19,224,063...19,241,620

G

epidermal growth factor receptor

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGFR mRNA

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

early growth response 1

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGR1 mRNA

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Vitamin B 12 inhibits the reaction [Streptozocin results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518

G

establishment of sister chromatid cohesion N-acetyltransferase 2

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ESCO2 mRNA

NCBI chr 8:27,771,974...27,819,660
Ensembl chr 8:27,771,949...27,812,640

G

fatty acid binding protein 5

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of FABP5 mRNA

NCBI chr 8:81,280,536...81,284,775
Ensembl chr 8:81,280,536...81,284,777

G

fatty acid desaturase 1

multiple interactions

[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA; [Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS1 protein; Folic Acid inhibits the reaction [[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA]; Folic Acid promotes the reaction [[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS1 protein]; Vitamin B 12 deficiency promotes the reaction [Folic Acid results in increased activity of FADS1 protein]

NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318

G

fatty acid desaturase 2

multiple interactions

[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS2 protein; [Vitamin B 12 deficiency co-treated with Folic Acid] results in decreased activity of FADS2 protein; Folic Acid inhibits the reaction [[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS2 protein]

NCBI chr11:61,816,203...61,867,354
Ensembl chr11:61,792,980...61,867,354

G

fatty acid synthase

multiple interactions

[Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid] affects the reaction [[Dietary Fats co-treated with Dietary Sucrose] affects the methylation of FASN promoter]

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

G

folate hydrolase 1

multiple interactions

Vitamin B 12 affects the reaction [FOLH1 gene SNP affects the susceptibility to and affects the metabolism of Arsenic]

NCBI chr11:49,145,092...49,208,602
Ensembl chr11:49,145,092...49,208,638

G

fucosyltransferase 2 (H blood group)

affects abundance

FUT2 gene polymorphism affects the abundance of Vitamin B 12

NCBI chr19:48,695,971...48,705,951
Ensembl chr19:48,695,971...48,705,951

G

growth arrest and DNA damage inducible beta

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GADD45B mRNA

NCBI chr19:2,476,127...2,478,257
Ensembl chr19:2,476,122...2,478,805

G

growth arrest and DNA damage inducible gamma

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of GADD45G mRNA

NCBI chr 9:89,605,012...89,606,555
Ensembl chr 9:89,605,012...89,606,555

G

glucokinase

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of GCK mRNA

NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170

G

glial cell derived neurotrophic factor

multiple interactions

Vitamin B 12 inhibits the reaction [Streptozocin results in decreased expression of GDNF protein]

NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041

G

glial fibrillary acidic protein

multiple interactions

Vitamin B 12 inhibits the reaction [Streptozocin results in increased expression of GFAP protein]

NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937

G

G protein subunit alpha 14

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GNA14 mRNA

NCBI chr 9:77,423,079...77,648,322
Ensembl chr 9:77,423,079...77,648,322

G

glycerophosphocholine phosphodiesterase 1

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of GPCPD1 mRNA

NCBI chr20:5,544,439...5,611,006
Ensembl chr20:5,544,404...5,611,006

G

glutathione S-transferase alpha 5

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GSTA5 mRNA; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of GSTA5 mRNA

NCBI chr 6:52,831,692...52,846,245
Ensembl chr 6:52,831,655...52,840,843

G

glutathione S-transferase mu 3

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GSTM3 mRNA

NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]

NCBI chr 4:155,666,848...155,737,059
Ensembl chr 4:155,666,726...155,737,059

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]

NCBI chr 4:155,759,021...155,807,811
Ensembl chr 4:155,758,992...155,807,811

G

hepatitis A virus cellular receptor 1

multiple interactions

[Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HAVCR1 protein]

NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396

G

hemoglobin subunit alpha 1

affects expression
affects glycosylation

Vitamin B 12 affects the expression of HBA1 protein modified form
Vitamin B 12 affects the glycosylation of HBA1 protein

NCBI chr16:176,680...177,522
Ensembl chr16:176,680...177,522

G

heme oxygenase 1

multiple interactions

[Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of HMOX1 protein]

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

heat shock protein family A (Hsp70) member 5

multiple interactions

[Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HSPA5 protein]
Vitamin B 12 inhibits the reaction [Streptozocin results in increased expression of HSPA5 protein]

PMID:37263574 PMID:38049026

NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382

G

interleukin 1 beta

increases methylation
multiple interactions

Vitamin B 12 results in increased methylation of IL1B gene
[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of IL1B mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of IL1B protein; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of IL1B gene

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

[Folic Acid co-treated with Vitamin B 12] inhibits the reaction [arsenic trioxide results in increased expression of IL6 protein]

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

insulin receptor substrate 2

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of IRS2 mRNA

NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583

G

integrin subunit alpha 8

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ITGA8 mRNA

NCBI chr10:15,513,954...15,719,922
Ensembl chr10:15,513,954...15,719,922

G

integrin subunit beta 4

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ITGB4 mRNA

NCBI chr17:75,721,459...75,757,818
Ensembl chr17:75,721,328...75,757,818

G

keratin 4

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of KRT4 mRNA

NCBI chr12:52,806,549...52,814,116
Ensembl chr12:52,806,549...52,814,116

G

kynureninase

multiple interactions

[Folic Acid co-treated with Vitamin B 12] inhibits the reaction [Rotenone results in decreased expression of KYNU mRNA]

NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833

G

leptin receptor

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of LEPR mRNA

NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559

G

LRAT domain containing 1

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of LRATD1 mRNA

NCBI chr 2:14,632,717...14,651,916
Ensembl chr 2:14,632,700...14,650,814

G

leucine rich repeat containing 24

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of LRRC24 mRNA

NCBI chr 8:144,522,388...144,527,033
Ensembl chr 8:144,522,388...144,527,033

G

monoamine oxidase B

decreases activity

Vitamin B 12 results in decreased activity of MAOB protein

NCBI chr X:43,766,610...43,882,450
Ensembl chr X:43,766,610...43,882,450

G

microtubule associated protein 2

multiple interactions

Vitamin B 12 inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein]

NCBI chr 2:209,424,047...209,734,112
Ensembl chr 2:209,424,047...209,734,147

G

mitogen-activated protein kinase kinase kinase kinase 1

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of MAP4K1 mRNA

NCBI chr19:38,587,641...38,617,953
Ensembl chr19:38,587,641...38,618,882

G

mitogen-activated protein kinase 1

multiple interactions

Vitamin B 12 inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

methionine adenosyltransferase 2A

multiple interactions

[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA; Fatty Acids, Omega-3 promotes the reaction [[Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA]

NCBI chr 2:85,539,168...85,545,281
Ensembl chr 2:85,539,168...85,545,281

G

myelin basic protein

multiple interactions

Vitamin B 12 inhibits the reaction [Streptozocin results in decreased expression of MBP protein]

NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683

G

minichromosome maintenance complex component 5

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MCM5 mRNA

NCBI chr22:35,400,140...35,455,031
Ensembl chr22:35,400,134...35,425,431

G

minichromosome maintenance complex component 6

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MCM6 mRNA

NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443

G

microtubule associated monooxygenase, calponin and LIM domain containing 1

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MICAL1 mRNA

NCBI chr 6:109,444,062...109,465,968
Ensembl chr 6:109,444,062...109,465,968

G

marker of proliferation Ki-67

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MKI67 mRNA

NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423

G

metabolism of cobalamin associated C

increases metabolic processing
affects binding
decreases metabolic processing

MMACHC protein results in increased metabolism of Vitamin B 12
Vitamin B 12 analog binds to MMACHC protein; Vitamin B 12 binds to MMACHC protein
MMACHC protein mutant form results in decreased metabolism of Vitamin B 12

NCBI chr 1:45,500,300...45,513,382
Ensembl chr 1:45,500,300...45,513,382

G

methylenetetrahydrofolate reductase

decreases expression
multiple interactions

Vitamin B 12 deficiency results in decreased expression of MTHFR mRNA
[Folic Acid co-treated with Vitamin B 12 deficiency] results in decreased expression of MTHFR mRNA; Fatty Acids, Omega-3 inhibits the reaction [Vitamin B 12 deficiency results in decreased expression of MTHFR mRNA]

NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455

G

5-methyltetrahydrofolate-homocysteine methyltransferase

affects binding
multiple interactions
increases activity

Vitamin B 12 binds to MTR protein
[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of MTR mRNA; Fatty Acids, Omega-3 promotes the reaction [Vitamin B 12 deficiency inhibits the reaction [Fatty Acids, Omega-3 results in increased expression of MTR mRNA]]; Vitamin B 12 deficiency inhibits the reaction [Fatty Acids, Omega-3 results in increased expression of MTR mRNA]
Vitamin B 12 results in increased activity of MTR protein

PMID:17477549 PMID:17982279 PMID:25003120

NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278

G

MYCL proto-oncogene, bHLH transcription factor

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of MYCL mRNA

NCBI chr 1:39,895,428...39,901,917
Ensembl chr 1:39,895,428...39,902,256

G

neutrophil cytosolic factor 1

multiple interactions

[Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NCF1 protein]

NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315

G

NFE2 like bZIP transcription factor 2

multiple interactions

[Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of NFE2L2 protein]

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nerve growth factor

multiple interactions

Vitamin B 12 inhibits the reaction [Streptozocin results in decreased expression of NGF protein]

NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770

G

NLR family pyrin domain containing 12

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of NLRP12 mRNA

NCBI chr19:53,793,584...53,824,403
Ensembl chr19:53,792,139...53,824,403

G

neuropeptide Y

multiple interactions

Vitamin B 12 affects the reaction [bisphenol A affects the expression of NPY mRNA]

NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of NQO1 protein]

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

phosphatidylethanolamine N-methyltransferase

multiple interactions

[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA; Fatty Acids, Omega-3 inhibits the reaction [[Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA]

NCBI chr17:17,505,563...17,592,142
Ensembl chr17:17,505,563...17,591,708

G

period circadian regulator 2

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of PER2 mRNA

NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102

G

peroxisome proliferator activated receptor alpha

multiple interactions

[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of PPARA protein

NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755

G

peroxisome proliferator activated receptor gamma

multiple interactions

[Folic Acid co-treated with Vitamin B 12] inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA]; Vitamin B 12 inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA]

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

protein phosphatase 1 regulatory subunit 3G

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of PPP1R3G mRNA

NCBI chr 6:5,085,341...5,089,487
Ensembl chr 6:5,085,341...5,089,487

G

serine protease 8

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA

NCBI chr16:31,131,433...31,135,727
Ensembl chr16:31,131,433...31,135,727

G

regulatory factor X4

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of RFX4 mRNA

NCBI chr12:106,583,004...106,762,803
Ensembl chr12:106,583,004...106,762,803

G

regulator of G protein signaling 16

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of RGS16 mRNA

NCBI chr 1:182,598,623...182,604,389
Ensembl chr 1:182,598,623...182,604,389

G

ribonucleotide reductase regulatory subunit M2

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of RRM2 mRNA

NCBI chr 2:10,122,568...10,211,010
Ensembl chr 2:10,120,698...10,211,725

G

S100 calcium binding protein A8

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of S100A8 mRNA

NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073

G

serpin family E member 1

multiple interactions
increases methylation

[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SERPINE1 mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of SERPINE1 gene
Vitamin B 12 results in increased methylation of SERPINE1 gene

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

serpin family H member 1

multiple interactions

Vitamin B 12 inhibits the reaction [Dimethylnitrosamine results in increased expression of SERPINH1 mRNA]

NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783

G

solute carrier family 25 member 30

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of SLC25A30 mRNA

NCBI chr13:45,393,316...45,434,016
Ensembl chr13:45,393,316...45,418,455

G

suppressor of cytokine signaling 2

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of SOCS2 mRNA

NCBI chr12:93,569,969...93,626,236
Ensembl chr12:93,569,814...93,583,487

G

sulfotransferase family 1E member 1

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of SULT1E1 mRNA

NCBI chr 4:69,821,122...69,860,145
Ensembl chr 4:69,841,212...69,860,145

G

synaptophysin

multiple interactions

Vitamin B 12 inhibits the reaction [Streptozocin results in decreased expression of SYP protein]

NCBI chr X:49,187,815...49,200,193
Ensembl chr X:49,187,815...49,200,218

G

transcobalamin 2

multiple interactions

TCN2 protein binds to and results in increased uptake of Vitamin B 12

NCBI chr22:30,607,174...30,627,271
Ensembl chr22:30,607,003...30,627,271

G

tyrosine hydroxylase

multiple interactions

Vitamin B 12 inhibits the reaction [Streptozocin results in decreased expression of TH protein]

NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815

G

tumor necrosis factor

multiple interactions

[Folic Acid co-treated with Vitamin B 12] inhibits the reaction [arsenic trioxide results in increased expression of TNF protein]
[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of TNF mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of TNF protein

PMID:16214333 PMID:30116142

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

unc-51 like autophagy activating kinase 1

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ULK1 mRNA

NCBI chr12:131,894,622...131,923,150
Ensembl chr12:131,894,622...131,923,150

G

ubiquitin specific peptidase 2

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of USP2 mRNA

NCBI chr11:119,355,215...119,381,690
Ensembl chr11:119,355,215...119,381,711

G

vanin 1

multiple interactions

[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of VNN1 mRNA

NCBI chr 6:132,680,849...132,714,055
Ensembl chr 6:132,680,849...132,714,055

glutathionylcobalamin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

5-methyltetrahydrofolate-homocysteine methyltransferase

multiple interactions

[glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form

NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278

hydroxocobalamin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

Hydroxocobalamin results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]

NCBI chr 4:155,666,848...155,737,059
Ensembl chr 4:155,666,726...155,737,059

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

Hydroxocobalamin results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]

NCBI chr 4:155,759,021...155,807,811
Ensembl chr 4:155,758,992...155,807,811

G

metabolism of cobalamin associated C

affects binding

Hydroxocobalamin binds to MMACHC protein

NCBI chr 1:45,500,300...45,513,382
Ensembl chr 1:45,500,300...45,513,382

G

5-methyltetrahydrofolate-homocysteine methyltransferase

multiple interactions

[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]

NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278

methylcobalamin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calpain 1

multiple interactions

mecobalamin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CAPN1 protein]

NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006

G

caspase 3

multiple interactions

mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 7

multiple interactions

mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP7 protein]

NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907

G

interferon gamma

multiple interactions

mecobalamin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IFNG protein]

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

myelin basic protein

multiple interactions

mecobalamin inhibits the reaction [Thioacetamide results in decreased expression of MBP mRNA]; mecobalamin inhibits the reaction [Thioacetamide results in decreased expression of MBP protein]

NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683

G

matrix metallopeptidase 2

multiple interactions

mecobalamin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of MMP2 protein]

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

5-methyltetrahydrofolate-homocysteine methyltransferase

multiple interactions
increases activity

Aluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]

NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26503
chemical entity	26483
molecular entity	26465
transition element molecular entity	19695
transition element coordination entity	12589
cobalt coordination entity	109
cobalt corrinoid +	109
cobalt trinitrate	0
cobalt(II) bis(acetylacetonate)	0
cobaltocene	0
hexaamminecobalt(2+)	0
hexaamminecobalt(3+) +	0
hexaamminecobalt(III) chloride	0
hexaaquacobalt(2+)	0
hexaaquacobalt(3+)	0
hexacyanocobaltate(3-)	0
methyl-Co(2+)	0
tetrachlorocobaltate(2-)	0
tetranitratocobaltate(2-)	0
Path 2
Term	Annotations
CHEBI ontology	26503
subatomic particle	26479
composite particle	26479
hadron	26479
baryon	26479
nucleon	26479
atomic nucleus	26479
atom	26479
metal atom	21656
transition element atom	20008
d-block element atom	20003
cobalt group element atom	4528
cobalt atom	4528
cobalt molecular entity	4390
cobalt coordination entity	109
cobalt corrinoid +	109
cobalt trinitrate	0
cobalt(II) bis(acetylacetonate)	0
cobaltocene	0
hexaamminecobalt(2+)	0
hexaamminecobalt(3+) +	0
hexaamminecobalt(III) chloride	0
hexaaquacobalt(2+)	0
hexaaquacobalt(3+)	0
hexacyanocobaltate(3-)	0
methyl-Co(2+)	0
tetrachlorocobaltate(2-)	0
tetranitratocobaltate(2-)	0

paths to the root