CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: arenecarbaldehyde
Accession: CHEBI:33855
browse the term
Definition: Any aldehyde in which the carbonyl group is attached to an aromatic moiety.
Synonyms: related_synonym: Aromatic aldehyde; Formula=CHOR; SMILES=*C(=O)[H]; an aromatic aldehyde; arenecarbaldehydes; aryl aldehyde; aryl aldehydes
alt_id: CHEBI:13819; CHEBI:22621; CHEBI:2832; CHEBI:87908
xref: KEGG:C00193; MetaCyc:Aryl-Aldehyde
G
Ar
androgen receptor
multiple interactions
EXP
1-naphthaldehyde inhibits the reaction [Metribolone binds to AR protein]
CTD
PMID:3695475
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Aldh2
aldehyde dehydrogenase 2 family member
increases metabolic processing
ISO
ALDH2 protein results in increased metabolism of 2,5-dihydroxybenzaldehyde
CTD
PMID:11744614
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Akr7a2
aldo-keto reductase family 7, member A2
increases reduction affects reduction
ISO
AKR7A2 protein results in increased reduction of 2-nitrobenzaldehyde 2-nitrobenzaldehyde affects the reduction of AKR7A5 protein
CTD
PMID:10510318 PMID:12604212
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
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Ache
acetylcholinesterase
multiple interactions
ISO
protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of ACHE protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]
CTD
PMID:29665407 PMID:29732668
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]
CTD
PMID:25582705
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Ager
advanced glycosylation end product-specific receptor
multiple interactions
ISO EXP
protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein] protocatechualdehyde inhibits the reaction [Bleomycin results in decreased expression of AGER protein]
CTD
PMID:17597607 PMID:25582705
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Cat
catalase
multiple interactions increases activity
ISO
protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of CAT protein] protocatechualdehyde results in increased activity of CAT protein
CTD
PMID:29665407 PMID:29732668
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cdh1
cadherin 1
multiple interactions
ISO
protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]
CTD
PMID:25582705
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Fgf2
fibroblast growth factor 2
multiple interactions
ISO EXP
protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of FGF2 protein] protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of FGF2 protein]
CTD
PMID:25582705
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G6pd
glucose-6-phosphate dehydrogenase
multiple interactions
ISO
protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of G6PD protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein]
CTD
PMID:29665407 PMID:29732668
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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Glo1
glyoxalase 1
multiple interactions
ISO
protocatechualdehyde inhibits the reaction [sodium arsenite results in increased activity of GLO1 protein]
CTD
PMID:29732668
NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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Gsr
glutathione-disulfide reductase
multiple interactions
ISO
protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of GSR protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]
CTD
PMID:29665407 PMID:29732668
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Hmgb1
high mobility group box 1
multiple interactions
EXP ISO
protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of HMGB1 protein] protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein]
CTD
PMID:25582705
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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S100b
S100 calcium binding protein B
multiple interactions
ISO
protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein]
CTD
PMID:17597607
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
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Smad2
SMAD family member 2
multiple interactions
ISO
protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein]
CTD
PMID:17597607
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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Smad3
SMAD family member 3
multiple interactions
ISO
protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein]
CTD
PMID:17597607
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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Sod1
superoxide dismutase 1
multiple interactions
ISO
protocatechualdehyde inhibits the reaction [Potassium Dichromate results in increased activity of SOD1 protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein]
CTD
PMID:29665407 PMID:29732668
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of FGF2 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]
CTD
PMID:17597607 PMID:25582705
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Vim
vimentin
multiple interactions
ISO
protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]
CTD
PMID:25582705
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
G
Ar
androgen receptor
multiple interactions
ISO
3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of AR protein
CTD
PMID:27633901
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Esr1
estrogen receptor 1
multiple interactions
ISO
3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of ESR1 protein
CTD
PMID:27633901
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions
ISO
3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of NR3C1 protein
CTD
PMID:27633901
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
G
Pgr
progesterone receptor
multiple interactions
ISO
3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PGR protein
CTD
PMID:27633901
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PPARG protein
CTD
PMID:27633901
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Thrb
thyroid hormone receptor beta
multiple interactions
ISO
3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of THRB protein
CTD
PMID:27633901
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
G
Aldh2
aldehyde dehydrogenase 2 family member
increases metabolic processing
ISO
ALDH2 protein results in increased metabolism of 3-hydroxybenzaldehyde
CTD
PMID:11744614
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
G
Akr1a1
aldo-keto reductase family 1 member A1
increases reduction
ISO
AKR1A1 protein results in increased reduction of 3-nitrobenzaldehyde
CTD
PMID:10510318
NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
G
Akr1b1
aldo-keto reductase family 1 member B1
increases reduction
ISO
AKR1B1 protein results in increased reduction of 3-nitrobenzaldehyde
CTD
PMID:10510318
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Akr7a2
aldo-keto reductase family 7, member A2
affects reduction
ISO
3-nitrobenzaldehyde affects the reduction of AKR7A5 protein; 3-nitrobenzaldehyde analog affects the reduction of AKR7A5 protein
CTD
PMID:12604212
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
decreases activity multiple interactions increases oxidation
ISO
4-(diethylamino)benzaldehyde results in decreased activity of ALDH1A1 protein 4-(diethylamino)benzaldehyde inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to mafosfamide] ALDH1A1 protein results in increased oxidation of 4-(diethylamino)benzaldehyde
CTD
PMID:8662658 PMID:16316642 PMID:25512087
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
G
Aldh1a2
aldehyde dehydrogenase 1 family, member A2
multiple interactions
ISO
4-(diethylamino)benzaldehyde binds to and results in decreased activity of ALDH1A2 protein
CTD
PMID:25512087
NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
G
Aldh2
aldehyde dehydrogenase 2 family member
multiple interactions
ISO
4-(diethylamino)benzaldehyde binds to and results in decreased activity of ALDH2 protein
CTD
PMID:25512087
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
G
Aldh3a1
aldehyde dehydrogenase 3 family, member A1
increases oxidation
ISO
ALDH3A1 protein results in increased oxidation of 4-(diethylamino)benzaldehyde
CTD
PMID:25512087
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
G
Akr1a1
aldo-keto reductase family 1 member A1
increases reduction
ISO
AKR1A1 protein results in increased reduction of 4-carboxybenzaladehyde
CTD
PMID:10510318
NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
G
Akr1a1
aldo-keto reductase family 1 member A1
increases reduction
ISO
AKR1A1 protein results in increased reduction of 4-nitrobenzaldehyde
CTD
PMID:10510318
NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
G
Akr1b1
aldo-keto reductase family 1 member B1
increases reduction
ISO
AKR1B1 protein results in increased reduction of 4-nitrobenzaldehyde
CTD
PMID:10510318
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
G
Akr1b8
aldo-keto reductase family 1, member B8
increases metabolic processing
ISO
AKR1B15 protein results in increased metabolism of 4-nitrobenzaldehyde
CTD
PMID:21276782
NCBI chr 4:62,997,241...63,009,815
Ensembl chr 4:62,997,161...63,010,097
G
Akr7a2
aldo-keto reductase family 7, member A2
multiple interactions affects reduction
ISO
Ethacrynic Acid inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]; Indomethacin inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]; Quercetin inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]; Valproic Acid inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]
CTD
PMID:12604212
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
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Dhrs7
dehydrogenase/reductase 7
increases reduction
ISO
DHRS7 protein results in increased reduction of 4-nitrobenzaldehyde
CTD
PMID:24246760
NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
G
Dyrk2
dual specificity tyrosine phosphorylation regulated kinase 2
multiple interactions
ISO
[Curcumin binds to 4-nitrobenzaldehyde] which results in decreased activity of DYRK2 protein
CTD
PMID:33617879
NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to 4-nitrobenzaldehyde]
CTD
PMID:20932822
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nphs1
NPHS1 adhesion molecule, nephrin
decreases expression
EXP
5-hydroxymethylfurfural co-treated with 3,4-dideoxyglucosone co-treated with Glyoxal co-treated with Methylglyoxal cotreated with 3-deoxyglucosone co-treated with Formaldehyde co-treated with acetaldehyde decreases expression of Nphs1 protein in kidneys
RGD
PMID:18346151
RGD:38599007
NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
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Sult1a1
sulfotransferase family 1A member 1
affects metabolic processing increases metabolic processing increases activity multiple interactions affects activity
ISO EXP
SULT1A1 protein affects the metabolism of 5-hydroxymethylfurfural SULT1A1 protein results in increased metabolism of 5-hydroxymethylfurfural SULT1A1 protein results in increased activity of 5-hydroxymethylfurfural [SULT1A1 protein co-treated with SULT1A2 protein] results in increased susceptibility to 5-hydroxymethylfurfural 5-hydroxymethylfurfural affects the activity of SULT1A1 protein
CTD
PMID:22006426 PMID:22349055 PMID:22563731 PMID:25370010
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases oxidation increases metabolic processing
EXP ISO
ALDH1A1 protein results in increased oxidation of benzaldehyde ALDH1A1 protein results in increased metabolism of benzaldehyde
CTD
PMID:10998257 PMID:21256123
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
G
Aldh2
aldehyde dehydrogenase 2 family member
increases metabolic processing multiple interactions
ISO
ALDH2 protein results in increased metabolism of benzaldehyde benzaldehyde inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]
CTD
PMID:10609638 PMID:11744614
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
G
Aldh3a1
aldehyde dehydrogenase 3 family, member A1
multiple interactions increases oxidation increases metabolic processing
ISO
[ALDH3A1 protein co-treated with NAD] results in increased oxidation of benzaldehyde; [ALDH3A1 protein co-treated with NADP] results in increased oxidation of benzaldehyde; Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde] ALDH3A1 protein results in increased metabolism of benzaldehyde
CTD
PMID:10856427 PMID:21256123 PMID:21349255 PMID:23220590 PMID:25512087
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
G
Aldh3b1
aldehyde dehydrogenase 3 family, member B1
affects binding
ISO
benzaldehyde binds to ALDH3B1 protein
CTD
PMID:20699116
NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921
G
Ar
androgen receptor
multiple interactions
EXP
benzaldehyde inhibits the reaction [Metribolone binds to AR protein]
CTD
PMID:3695475
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Or8a1b
olfactory receptor family 8 subfamily A member 1B
multiple interactions
ISO
benzaldehyde binds to and results in increased activity of OR8A1 protein
CTD
PMID:11943806
NCBI chr 8:37,434,903...37,435,832
Ensembl chr 8:37,434,551...37,439,746
G
Slc2a1
solute carrier family 2 member 1
increases activity multiple interactions
ISO
benzaldehyde results in increased activity of SLC2A1 protein [benzaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein
CTD
PMID:20955755
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
G
Aldh1a2
aldehyde dehydrogenase 1 family, member A2
decreases activity
ISO
Benzaldehydes results in decreased activity of ALDH1A2 protein
CTD
PMID:22079344
NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
G
Aldh2
aldehyde dehydrogenase 2 family member
decreases activity
ISO
Benzaldehydes results in decreased activity of ALDH2 protein
CTD
PMID:22079344
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
G
Or5d18
olfactory receptor family 5 subfamily D member 18
multiple interactions
ISO
[ethyl vanillin binds to and results in increased activity of OR5D18 protein] which results in increased transport of Calcium; ethyl vanillin binds to and results in increased activity of OR5D18 protein
CTD
PMID:15716417
NCBI chr 3:73,516,522...73,517,463
Ensembl chr 3:73,516,364...73,519,858 Ensembl chr 3:73,516,364...73,519,858
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Trpv3
transient receptor potential cation channel, subfamily V, member 3
increases activity
ISO
ethyl vanillin results in increased activity of TRPV3 protein
CTD
PMID:16617338
NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
decreases activity
EXP
3-methylbenzaldehyde results in decreased activity of CYP2B1 protein
CTD
PMID:12791539
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity
EXP
3-methylbenzaldehyde results in decreased activity of CYP2E1 protein
CTD
PMID:12791539
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
affects activity
EXP
3-methylbenzaldehyde affects the activity of CYP4B1 protein
CTD
PMID:12791539
NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
G
Kras
KRAS proto-oncogene, GTPase
increases response to substance
ISO
KRAS protein mutant form results in increased susceptibility to oncrasin-1
CTD
PMID:21443218
NCBI chr 4:178,185,418...178,218,484
G
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
increases glucuronidation
ISO
UGT1A3 protein results in increased glucuronidation of 2-vanillin
CTD
PMID:15117964
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Trpa1
transient receptor potential cation channel, subfamily A, member 1
increases activity
ISO
4-anisaldehyde results in increased activity of TRPA1 protein
CTD
PMID:21591660
NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
4-methylbenzaldehyde binds to and results in decreased activity of AHR protein
CTD
PMID:27633901
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Ar
androgen receptor
multiple interactions
ISO
4-methylbenzaldehyde binds to and results in decreased activity of AR protein
CTD
PMID:27633901
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Esr2
estrogen receptor 2
multiple interactions
ISO
4-methylbenzaldehyde binds to and results in decreased activity of ESR2 protein
CTD
PMID:27633901
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Il1b
interleukin 1 beta
multiple interactions
ISO
4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IL1B protein]
CTD
PMID:27569861
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO
4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD
PMID:27569861
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD
PMID:27569861
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD
PMID:27569861
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]
CTD
PMID:27569861
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD
PMID:27569861
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:27569861
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Pgr
progesterone receptor
multiple interactions
ISO
4-methylbenzaldehyde binds to and results in decreased activity of PGR protein
CTD
PMID:27633901
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
4-methylbenzaldehyde binds to and results in decreased activity of PPARG protein
CTD
PMID:27633901
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:27569861
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
CTD
PMID:27569861
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Tnf
tumor necrosis factor
multiple interactions
ISO
4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:27569861
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Aicda
activation-induced cytidine deaminase
affects expression
ISO
o-Phthalaldehyde affects the expression of AICDA mRNA
CTD
PMID:22302311
NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972
G
Akr1c3
aldo-keto reductase family 1, member C3
affects expression
ISO
o-Phthalaldehyde affects the expression of AKR1C18 mRNA
CTD
PMID:22302311
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
G
Ccl9
C-C motif chemokine ligand 9
affects expression
ISO
o-Phthalaldehyde affects the expression of CCL6 mRNA
CTD
PMID:22302311
NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
G
Ccna2
cyclin A2
affects expression
ISO
o-Phthalaldehyde affects the expression of CCNA2 mRNA
CTD
PMID:22302311
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
G
Ccnb1
cyclin B1
affects expression
ISO
o-Phthalaldehyde affects the expression of CCNB1 mRNA
CTD
PMID:22302311
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
G
Ccne2
cyclin E2
affects expression
ISO
o-Phthalaldehyde affects the expression of CCNE2 mRNA
CTD
PMID:22302311
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
G
Ccr4
C-C motif chemokine receptor 4
affects expression
ISO
o-Phthalaldehyde affects the expression of CCR4 mRNA
CTD
PMID:22302311
NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056
G
Cd207
CD207 molecule
affects expression
ISO
o-Phthalaldehyde affects the expression of CD207 mRNA
CTD
PMID:22302311
NCBI chr 4:116,155,229...116,161,587
Ensembl chr 4:116,155,212...116,161,518
G
Cd5l
Cd5 molecule-like
affects expression
ISO
o-Phthalaldehyde affects the expression of CD5L mRNA
CTD
PMID:22302311
NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
G
Cd83
CD83 molecule
affects expression
ISO
o-Phthalaldehyde affects the expression of CD83 mRNA
CTD
PMID:22302311
NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
G
Cdc20
cell division cycle 20
affects expression
ISO
o-Phthalaldehyde affects the expression of CDC20 mRNA
CTD
PMID:22302311
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
G
Cdc25c
cell division cycle 25C
affects expression
ISO
o-Phthalaldehyde affects the expression of CDC25C mRNA
CTD
PMID:22302311
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
G
Cdk1
cyclin-dependent kinase 1
affects expression
ISO
o-Phthalaldehyde affects the expression of CDK1 mRNA
CTD
PMID:22302311
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
G
Clec7a
C-type lectin domain containing 7A
affects expression
ISO
o-Phthalaldehyde affects the expression of CLEC7A mRNA
CTD
PMID:22302311
NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897
G
Col8a1
collagen type VIII alpha 1 chain
affects expression
ISO
o-Phthalaldehyde affects the expression of COL8A1 mRNA
CTD
PMID:22302311
NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424
G
Cphx1
cytoplasmic polyadenylated homeobox 1
affects expression
ISO
o-Phthalaldehyde affects the expression of CPHX1 mRNA
CTD
PMID:22302311
NCBI chr16:1,533,883...1,537,248
Ensembl chr16:1,528,440...1,537,082
G
Ctla4
cytotoxic T-lymphocyte-associated protein 4
affects expression
ISO
o-Phthalaldehyde affects the expression of CTLA4 mRNA
CTD
PMID:22302311
NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases expression
ISO
o-Phthalaldehyde results in decreased expression of CYP1A1 mRNA
CTD
PMID:20112102
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases expression
ISO
o-Phthalaldehyde results in decreased expression of CYP2E1 mRNA
CTD
PMID:20112102
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Dio1
iodothyronine deiodinase 1
decreases activity
ISO
o-Phthalaldehyde results in decreased activity of DIO1 protein
CTD
PMID:30561685
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
G
Dio2
iodothyronine deiodinase 2
decreases activity
ISO
o-Phthalaldehyde results in decreased activity of DIO2 protein
CTD
PMID:30561685
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
G
Dio3
iodothyronine deiodinase 3
decreases activity
ISO
o-Phthalaldehyde results in decreased activity of DIO3 protein
CTD
PMID:30561685
NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
G
E2f1
E2F transcription factor 1
affects expression
ISO
o-Phthalaldehyde affects the expression of E2F1 mRNA
CTD
PMID:22302311
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
G
Fabp7
fatty acid binding protein 7
affects expression
ISO
o-Phthalaldehyde affects the expression of FABP7 mRNA
CTD
PMID:22302311
NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
G
Fxyd4
FXYD domain-containing ion transport regulator 4
affects expression
ISO
o-Phthalaldehyde affects the expression of FXYD4 mRNA
CTD
PMID:22302311
NCBI chr 4:151,109,779...151,113,659
Ensembl chr 4:151,109,779...151,113,637
G
Gzmb
granzyme B
affects expression
ISO
o-Phthalaldehyde affects the expression of GZMB mRNA
CTD
PMID:22302311
NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
G
Ifng
interferon gamma
increases expression
ISO
o-Phthalaldehyde results in increased expression of IFNG mRNA
CTD
PMID:21785612
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il10
interleukin 10
increases expression
ISO
o-Phthalaldehyde results in increased expression of IL10 mRNA
CTD
PMID:21785612
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il12b
interleukin 12B
affects expression
ISO
o-Phthalaldehyde affects the expression of IL12B mRNA
CTD
PMID:22302311
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
G
Il13
interleukin 13
increases expression
ISO
o-Phthalaldehyde results in increased expression of IL13 mRNA
CTD
PMID:21785612
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
G
Il1b
interleukin 1 beta
increases expression
ISO
o-Phthalaldehyde results in increased expression of IL1B mRNA
CTD
PMID:21785612
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il21
interleukin 21
affects expression
ISO
o-Phthalaldehyde affects the expression of IL21 mRNA
CTD
PMID:22302311
NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996
G
Il2ra
interleukin 2 receptor subunit alpha
affects expression
ISO
o-Phthalaldehyde affects the expression of IL2RA mRNA
CTD
PMID:22302311
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
G
Il4
interleukin 4
affects expression increases expression
ISO
o-Phthalaldehyde affects the expression of IL4 mRNA o-Phthalaldehyde results in increased expression of IL4 mRNA; o-Phthalaldehyde results in increased expression of IL4 protein
CTD
PMID:19110043 PMID:20176622 PMID:21785612 PMID:22302311
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il5
interleukin 5
increases expression
ISO
o-Phthalaldehyde results in increased expression of IL5 mRNA
CTD
PMID:19110043 PMID:21785612
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
G
Itgav
integrin subunit alpha V
affects expression
ISO
o-Phthalaldehyde affects the expression of ITGAV mRNA
CTD
PMID:22302311
NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
G
Iyd
iodotyrosine deiodinase
multiple interactions
ISO
o-Phthalaldehyde inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]
CTD
PMID:33352258
NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
G
Lgals7
galectin 7
affects expression
ISO
o-Phthalaldehyde affects the expression of LGALS7 mRNA
CTD
PMID:22302311
NCBI chr 1:84,148,612...84,152,016
Ensembl chr 1:84,150,252...84,152,015
G
Mki67
marker of proliferation Ki-67
affects expression
ISO
o-Phthalaldehyde affects the expression of MKI67 mRNA
CTD
PMID:22302311
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
G
Nts
neurotensin
affects expression
ISO
o-Phthalaldehyde affects the expression of NTS mRNA
CTD
PMID:22302311
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
G
Thbs1
thrombospondin 1
affects expression
ISO
o-Phthalaldehyde affects the expression of THBS1 mRNA
CTD
PMID:22302311
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
G
Thbs4
thrombospondin 4
affects expression
ISO
o-Phthalaldehyde affects the expression of THBS4 mRNA
CTD
PMID:22302311
NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
G
Timd2
T-cell immunoglobulin and mucin domain containing 2
affects expression
ISO
o-Phthalaldehyde affects the expression of TIMD2 mRNA
CTD
PMID:22302311
NCBI chr10:31,060,308...31,101,262
Ensembl chr10:31,060,326...31,094,623
G
Timp1
TIMP metallopeptidase inhibitor 1
affects expression
ISO
o-Phthalaldehyde affects the expression of TIMP1 mRNA
CTD
PMID:22302311
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
G
Tnf
tumor necrosis factor
increases expression
ISO
o-Phthalaldehyde results in increased expression of TNF mRNA
CTD
PMID:21785612
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
affects activity
ISO
o-Phthalaldehyde affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Trpm6
transient receptor potential cation channel, subfamily M, member 6
affects expression
ISO
o-Phthalaldehyde affects the expression of TRPM6 mRNA
CTD
PMID:22302311
NCBI chr 1:216,136,407...216,320,523
Ensembl chr 1:216,170,038...216,320,520
G
Ache
acetylcholinesterase
multiple interactions
EXP
vanillin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of ACHE protein]
CTD
PMID:33823243
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Akr1c2
aldo-keto reductase family 1, member C2
increases expression
ISO
vanillin results in increased expression of AKR1C2 mRNA
CTD
PMID:20491607
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
G
Car1
carbonic anhydrase 1
decreases activity
ISO
vanillin results in decreased activity of CA1 protein
CTD
PMID:19231207
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
G
Car2
carbonic anhydrase 2
decreases activity
ISO
vanillin results in decreased activity of CA2 protein
CTD
PMID:19231207
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Casp3
caspase 3
multiple interactions
EXP
vanillin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; vanillin inhibits the reaction [Methotrexate results in increased activity of CASP3 protein]
CTD
PMID:29216766
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Cat
catalase
multiple interactions
ISO EXP
vanillin inhibits the reaction [potassium bromate results in increased activity of CAT protein] vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein] vanillin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased activity of CAT protein]
CTD
PMID:26296324 PMID:33823243 PMID:37336463
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
vanillin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]
CTD
PMID:36416909
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Ccn2
cellular communication network factor 2
decreases expression
ISO
vanillin results in decreased expression of CCN2 mRNA
CTD
PMID:17178418
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
G
Clk2
CDC-like kinase 2
increases expression
ISO
vanillin results in increased expression of CLK2 mRNA
CTD
PMID:17178418
NCBI chr 2:174,570,614...174,582,645
Ensembl chr 2:174,570,653...174,588,985
G
Cst3
cystatin C
multiple interactions
EXP
vanillin inhibits the reaction [Cisplatin results in increased expression of CST3 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of CST3 protein]
CTD
PMID:29216766
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
vanillin results in increased expression of CYP1A1 mRNA
CTD
PMID:20491607
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Ddit4
DNA-damage-inducible transcript 4
increases expression
ISO
vanillin results in increased expression of DDIT4 mRNA
CTD
PMID:17178418
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
G
Dnmt3b
DNA methyltransferase 3 beta
decreases expression
ISO
vanillin results in decreased expression of DNMT3B mRNA
CTD
PMID:17178418
NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
G
Dusp6
dual specificity phosphatase 6
decreases expression
ISO
vanillin results in decreased expression of DUSP6 mRNA
CTD
PMID:17178418
NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
G
Faslg
Fas ligand
multiple interactions
EXP
vanillin inhibits the reaction [Cisplatin results in increased expression of FASLG protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of FASLG protein]
CTD
PMID:29216766
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
G
Fbp1
fructose-bisphosphatase 1
affects binding
ISO
vanillin binds to FBP1 protein
CTD
PMID:33823243
NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
G
Fgfr2
fibroblast growth factor receptor 2
decreases expression
ISO
vanillin results in decreased expression of FGFR2 mRNA
CTD
PMID:17178418
NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
G
Fzd2
frizzled class receptor 2
decreases expression
ISO
vanillin results in decreased expression of FZD2 mRNA
CTD
PMID:17178418
NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
affects binding
ISO
vanillin binds to G6PC1 protein
CTD
PMID:33823243
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
G
G6pd
glucose-6-phosphate dehydrogenase
multiple interactions
ISO
vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]
CTD
PMID:37336463
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
multiple interactions
ISO
vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GAPDH protein]
CTD
PMID:37336463
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
vanillin results in increased expression of GCLC mRNA
CTD
PMID:17178418
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
vanillin results in increased expression of GCLM mRNA
CTD
PMID:17178418
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Glo1
glyoxalase 1
multiple interactions
ISO
vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GLO1 protein]
CTD
PMID:37336463
NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
G
Gsr
glutathione-disulfide reductase
multiple interactions
ISO
vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]
CTD
PMID:37336463
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Hmox1
heme oxygenase 1
increases expression
ISO
vanillin results in increased expression of HMOX1 mRNA
CTD
PMID:17178418
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hprt1
hypoxanthine phosphoribosyltransferase 1
decreases mutagenesis
ISO
vanillin results in decreased mutagenesis of HPRT1 gene
CTD
PMID:17178418
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
G
Hspa1b
heat shock protein family A (Hsp70) member 1B
increases expression
ISO
vanillin results in increased expression of HSPA1B mRNA
CTD
PMID:17178418
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
G
Il12b
interleukin 12B
multiple interactions
ISO
vanillin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein]
CTD
PMID:36416909
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
G
Il18
interleukin 18
multiple interactions
EXP
vanillin inhibits the reaction [Cisplatin results in increased expression of IL18 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of IL18 protein]
CTD
PMID:29216766
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
multiple interactions
ISO
vanillin inhibits the reaction [potassium bromate results in increased expression of IL1B mRNA]
CTD
PMID:26296324
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO
vanillin inhibits the reaction [potassium bromate results in increased expression of IL6 mRNA]
CTD
PMID:26296324
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Insig1
insulin induced gene 1
decreases expression
ISO
vanillin results in decreased expression of INSIG1 mRNA
CTD
PMID:17178418
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
G
Jund
JunD proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
vanillin results in decreased expression of JUND mRNA
CTD
PMID:17178418
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
G
Lcn2
lipocalin 2
multiple interactions
EXP
vanillin inhibits the reaction [Cisplatin results in increased expression of LCN2 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of LCN2 protein]
CTD
PMID:29216766
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
G
Map2k2
mitogen activated protein kinase kinase 2
decreases expression
ISO
vanillin results in decreased expression of MAP2K2 mRNA
CTD
PMID:17178418
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
G
Mark4
microtubule affinity regulating kinase 4
decreases expression
ISO
vanillin results in decreased expression of MARK4 mRNA
CTD
PMID:17178418
NCBI chr 1:79,075,353...79,108,882
Ensembl chr 1:79,068,904...79,108,556
G
Mt1
metallothionein 1
multiple interactions
ISO
vanillin inhibits the reaction [potassium bromate results in increased expression of MT1 mRNA]
CTD
PMID:27074584
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
G
Mt2A
metallothionein 2A
increases expression multiple interactions
ISO
vanillin results in increased expression of MT2A mRNA vanillin inhibits the reaction [potassium bromate results in increased expression of MT2 mRNA]
CTD
PMID:20491607 PMID:27074584
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
G
Nos2
nitric oxide synthase 2
multiple interactions
EXP
vanillin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]
CTD
PMID:29216766
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Ppp1r10
protein phosphatase 1, regulatory subunit 10
decreases expression
ISO
vanillin results in decreased expression of PPP1R10 mRNA
CTD
PMID:17178418
NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
vanillin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; vanillin inhibits the reaction [potassium bromate results in increased expression of PTGS2 mRNA]
CTD
PMID:17465205 PMID:26296324
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Pygl
glycogen phosphorylase L
affects binding
ISO
vanillin binds to PYGL protein
CTD
PMID:33823243
NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
vanillin inhibits the reaction [Cisplatin results in increased expression of RELA protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of RELA protein]
CTD
PMID:29216766
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Slc35d2
solute carrier family 35 member D2
decreases expression
ISO
vanillin results in decreased expression of SLC35D2 mRNA
CTD
PMID:17178418
NCBI chr17:987,899...1,019,747
Ensembl chr17:988,157...1,019,743
G
Slc7a11
solute carrier family 7 member 11
increases expression
ISO
vanillin results in increased expression of SLC7A11 mRNA
CTD
PMID:17178418
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
G
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
decreases expression
ISO
vanillin results in decreased expression of TGFB1I1 mRNA
CTD
PMID:17178418
NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080
G
Tnf
tumor necrosis factor
multiple interactions
ISO EXP
vanillin inhibits the reaction [potassium bromate results in increased expression of TNF mRNA] vanillin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] vanillin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of TNF protein]
CTD
PMID:26296324 PMID:29216766 PMID:36416909
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
decreases expression
ISO
vanillin results in decreased expression of TP53 mRNA
CTD
PMID:17178418
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Trim16
tripartite motif-containing 16
increases expression
ISO
vanillin results in increased expression of TRIM16 mRNA
CTD
PMID:17178418
NCBI chr10:47,485,982...47,509,010
Ensembl chr10:47,486,297...47,551,907
G
Trpv3
transient receptor potential cation channel, subfamily V, member 3
increases activity
ISO
vanillin results in increased activity of TRPV3 protein
CTD
PMID:16617338
NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
G
Ugp2
UDP-glucose pyrophosphorylase 2
increases expression
ISO
vanillin results in increased expression of UGP2 mRNA
CTD
PMID:17178418
NCBI chr14:95,456,330...95,497,483
Ensembl chr14:95,456,330...95,496,830
G
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
increases glucuronidation
ISO
UGT1A3 protein results in increased glucuronidation of vanillin
CTD
PMID:15117964
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19915
role
19885
application
19727
solvent
17230
formic acid
9095
formyl group
9048
aldehyde
9048
arenecarbaldehyde
139
1,3-Dimethyl-1H-pyrazole-4-carbaldehyde
0
1,3-thiazole-2-carbaldehyde +
0
1-Ethyl-1H-pyrrole-2-carboxaldehyde
0
1-Methyl-2-pyrrolecarboxaldehyde
0
1-acetylindole-3-carboxaldehyde
0
2,5-diformylfuran
0
2,5-dimethyl-1-(phenylmethyl)pyrrole-3,4-dicarboxaldehyde
0
2-(dihydroxymethyl)-5-formylfuran
0
4'-methyl-2,2'-bipyridine-4-carboxaldehyde
0
4-(phosphooxymethyl)-2-furancarboxaldehyde
0
4-Hydroxy-2,2'-bipyrrole-5-carbaldehyde
0
4-ethylpyrrole-2-carboxaldehyde
0
5-(\{5-[(5-(hydroxymethyl)furan-2-yl)methoxy(methoxymethyl)]furan-2-yl\}methoxy(methoxymethyl))furan-2-carbaldehyde
0
5-Methoxymethyl furfural
0
5-Sulfoxymethylfurfural
0
5-[(5-hydroxymethyl-furan-2-yl)methoxy-methoxymethyl]-furan-2-carbaldehyde
0
5-formyl-2-furoic acid
0
5-hydroxymethylfurfural
2
8-formyl-8-demethylriboflavin 5'-phosphate
0
Baldrinal
0
Ganoine
0
Irpexlacte B
0
Irpexlacte C
0
Jiangrine E
0
N-[4-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-butyl]-acetamide
0
N-[5-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-pentyl]-acetamide
0
Phlebopine A
0
Phlebopine B
0
Viburtinal
0
aromatic (S)-hydroxynitrile
0
benzaldehydes +
136
cyathusal A
0
cyathusal B
0
cyathusal C
0
demethylzeylasteral
0
grixazone A
0
kadsurenin M
0
mycobilin a
0
mycobilin b
0
naphthaldehydes +
1
oncrasin-1
1
piperonal
0
Path 2
CHEBI ontology
19915
subatomic particle
19913
composite particle
19895
hadron
19895
baryon
19913
nucleon
19895
atomic nucleus
19913
atom
19895
main group element atom
19852
p-block element atom
19834
carbon group element atom
19774
carbon atom
19770
organic molecular entity
19770
heteroorganic entity
19542
organochalcogen compound
19302
organooxygen compound
19218
carbon oxoacid
18664
carboxylic acid
18661
carboacyl group
17700
univalent carboacyl group
17700
formyl group
9048
aldehyde
9048
arenecarbaldehyde
139
1,3-Dimethyl-1H-pyrazole-4-carbaldehyde
0
1,3-thiazole-2-carbaldehyde +
0
1-Ethyl-1H-pyrrole-2-carboxaldehyde
0
1-Methyl-2-pyrrolecarboxaldehyde
0
1-acetylindole-3-carboxaldehyde
0
2,5-diformylfuran
0
2,5-dimethyl-1-(phenylmethyl)pyrrole-3,4-dicarboxaldehyde
0
2-(dihydroxymethyl)-5-formylfuran
0
4'-methyl-2,2'-bipyridine-4-carboxaldehyde
0
4-(phosphooxymethyl)-2-furancarboxaldehyde
0
4-Hydroxy-2,2'-bipyrrole-5-carbaldehyde
0
4-ethylpyrrole-2-carboxaldehyde
0
5-(\{5-[(5-(hydroxymethyl)furan-2-yl)methoxy(methoxymethyl)]furan-2-yl\}methoxy(methoxymethyl))furan-2-carbaldehyde
0
5-Methoxymethyl furfural
0
5-Sulfoxymethylfurfural
0
5-[(5-hydroxymethyl-furan-2-yl)methoxy-methoxymethyl]-furan-2-carbaldehyde
0
5-formyl-2-furoic acid
0
5-hydroxymethylfurfural
2
8-formyl-8-demethylriboflavin 5'-phosphate
0
Baldrinal
0
Ganoine
0
Irpexlacte B
0
Irpexlacte C
0
Jiangrine E
0
N-[4-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-butyl]-acetamide
0
N-[5-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-pentyl]-acetamide
0
Phlebopine A
0
Phlebopine B
0
Viburtinal
0
aromatic (S)-hydroxynitrile
0
benzaldehydes +
136
cyathusal A
0
cyathusal B
0
cyathusal C
0
demethylzeylasteral
0
grixazone A
0
kadsurenin M
0
mycobilin a
0
mycobilin b
0
naphthaldehydes +
1
oncrasin-1
1
piperonal
0