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G |
Ache |
acetylcholinesterase |
affects binding multiple interactions increases hydrolysis |
ISO |
Carbachol binds to ACHE protein Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Carbachol results in increased metabolism of and results in increased secretion of ACHE protein ACHE protein results in increased hydrolysis of Carbachol |
CTD |
PMID:18602908 PMID:20493829 PMID:23047022 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Adcy5 |
adenylate cyclase 5 |
increases response to substance |
ISO |
ADCY5 protein results in increased susceptibility to Carbachol |
CTD |
PMID:12869393 |
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NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation |
EXP |
Carbachol increases phosphorylation of Akt1 protein in neuroepithelial stem cells |
RGD |
PMID:12676135 |
RGD:408346754 |
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
Carbachol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; Carbachol inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; Carbachol inhibits the reaction [APP protein modified form results in increased expression of FOS protein]; Carbachol inhibits the reaction [APP protein modified form results in increased expression of TRP53 protein] |
CTD |
PMID:10758335 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Aqp5 |
aquaporin 5 |
affects localization |
ISO |
Carbachol affects the localization of AQP5 protein |
CTD |
PMID:19443731 |
|
NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
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G |
Avpr1a |
arginine vasopressin receptor 1A |
multiple interactions |
EXP |
Carbachol promotes the reaction [[NC 1900 results in increased activity of AVPR1A protein] which results in increased abundance of Calcium]; Nicardipine inhibits the reaction [Carbachol promotes the reaction [[NC 1900 results in increased activity of AVPR1A protein] which results in increased abundance of Calcium]] |
CTD |
PMID:12646291 |
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NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
Carbachol inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; Carbachol inhibits the reaction [domoic acid results in increased localization of BAX protein] |
CTD |
PMID:10758335 PMID:19200344 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression multiple interactions |
ISO EXP |
Carbachol results in increased expression of BCL2 protein Carbachol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein] |
CTD |
PMID:10758335 PMID:17708838 PMID:19200344 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Btg2 |
BTG anti-proliferation factor 2 |
increases expression multiple interactions |
EXP |
Carbachol results in increased expression of BTG2 mRNA Tetradecanoylphorbol Acetate inhibits the reaction [Carbachol results in increased expression of BTG2 mRNA] |
CTD |
PMID:2005087 |
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NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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G |
Casp3 |
caspase 3 |
multiple interactions decreases expression |
ISO EXP |
Carbachol inhibits the reaction [domoic acid results in increased activity of CASP3 protein] Carbachol results in decreased expression of CASP3 protein |
CTD |
PMID:17708838 PMID:19200344 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cd40 |
CD40 molecule |
multiple interactions increases expression |
ISO |
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased expression of CD40 protein]; 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Carbachol results in increased expression of CD40 protein]; Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein]; Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein] |
CTD |
PMID:16879495 |
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NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
increases activity multiple interactions affects binding |
ISO |
Carbachol results in increased activity of CHRM1 protein [Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG mRNA; [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG protein; brucine promotes the reaction [Carbachol binds to CHRM1 protein] CHRM1 protein binds to Carbachol 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; 1-oleoyl-2-acetylglycerol promotes the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; [Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Flufenamic Acid inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Gadolinium inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Lanthanum inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Thapsigargin inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] |
CTD |
PMID:8683117 PMID:9224827 PMID:11527950 PMID:18316702 |
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NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
multiple interactions affects binding |
ISO |
eburnamonine promotes the reaction [Carbachol binds to CHRM2 protein] CHRM2 protein binds to Carbachol Carbachol binds to and results in increased activity of CHRM2 protein; Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]] |
CTD |
PMID:9224827 PMID:11181912 PMID:19002953 |
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NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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G |
Chrm3 |
cholinergic receptor, muscarinic 3 |
multiple interactions increases activity affects binding affects response to substance increases response to substance |
ISO EXP |
Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]; brucine promotes the reaction [Carbachol binds to CHRM3 protein]; brucine promotes the reaction [Carbachol results in increased activity of CHRM3 protein mutant form]; Carbachol binds to and results in increased activity of CHRM3 protein; Carbachol binds to and results in increased activity of CHRM3 protein mutant form; Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]; Guanylyl Imidodiphosphate inhibits the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]; Zinc Oxide promotes the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]] CHRM3 protein binds to Carbachol CHRM3 protein affects the susceptibility to Carbachol CHRM3 protein results in increased susceptibility to Carbachol [Metoclopramide binds to and results in decreased activity of CHRM3 protein] which results in decreased susceptibility to Carbachol |
CTD |
PMID:9224827 PMID:14724830 PMID:15105209 PMID:19407017 PMID:20466821 PMID:20708676 More...
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NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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G |
Chrm4 |
cholinergic receptor, muscarinic 4 |
multiple interactions affects binding |
ISO |
brucine promotes the reaction [Carbachol binds to CHRM4 protein] CHRM4 protein binds to Carbachol |
CTD |
PMID:9224827 |
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NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
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G |
Chrna2 |
cholinergic receptor nicotinic alpha 2 subunit |
multiple interactions |
EXP |
carbachol affects binding competes with [Epibatidine binds to Chrna2 protein] |
RGD |
PMID:15016836 |
RGD:2303194 |
NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
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G |
Chrna3 |
cholinergic receptor nicotinic alpha 3 subunit |
affects binding multiple interactions |
EXP |
Carbachol binds to [CHRNA3 protein binds to CHRNB4 protein] Carbachol affects binding [Epibatidine binds to Chrna3 protein] |
CTD RGD |
PMID:15615518 PMID:15016836 |
RGD:2303194 |
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
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G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
multiple interactions affects binding |
ISO EXP |
Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] Carbachol binds to [CHRNA4 protein binds to CHRNB2 protein] carbachol affects binding to Chrna4 protein; carbachol competes with [Epibatidine binds to Chrna4 protein] |
CTD RGD |
PMID:14645658 PMID:15615518 PMID:15016836 |
RGD:2303194 |
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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G |
Chrna7 |
cholinergic receptor nicotinic alpha 7 subunit |
multiple interactions affects activity |
ISO EXP |
1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Carbachol affects the activity of CHRNA7 protein]; Carbachol inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; Carbachol inhibits the reaction [epibatidine binds to CHRNA7 protein] Carbachol affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein] |
CTD |
PMID:10216184 PMID:19448648 PMID:21703337 PMID:29248576 |
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NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
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G |
Chrnb2 |
cholinergic receptor nicotinic beta 2 subunit |
multiple interactions affects binding |
ISO EXP |
Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] Carbachol binds to [CHRNA4 protein binds to CHRNB2 protein] carbachol affects binding to Chrnb2 protein; carbachol competes with [Epibatidine binds to Chrnb2 protein] |
CTD RGD |
PMID:14645658 PMID:15615518 PMID:15016836 |
RGD:2303194 |
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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G |
Chrnb4 |
cholinergic receptor nicotinic beta 4 subunit |
affects binding |
EXP |
Carbachol binds to [CHRNA3 protein binds to CHRNB4 protein] |
CTD |
PMID:15615518 |
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NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
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G |
Creb1 |
cAMP responsive element binding protein 1 |
affects phosphorylation |
EXP |
Carbachol affects the phosphorylation of CREB1 protein |
CTD |
PMID:21295078 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Eef2 |
eukaryotic translation elongation factor 2 |
decreases phosphorylation |
ISO |
carbachol decreases phosphorylation of EEF2 protein in colon cancer cells |
RGD |
PMID:31227218 |
RGD:153298919 |
NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
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G |
Egr1 |
early growth response 1 |
multiple interactions increases expression |
EXP |
Tetradecanoylphorbol Acetate inhibits the reaction [Carbachol results in increased expression of EGR1 mRNA] |
CTD |
PMID:2005087 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Faslg |
Fas ligand |
multiple interactions |
ISO |
[Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG mRNA; [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG protein |
CTD |
PMID:8683117 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fgf1 |
fibroblast growth factor 1 |
increases expression multiple interactions |
EXP |
Carbachol results in increased expression of FGF1 protein KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]; Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein] |
CTD |
PMID:15264218 |
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NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP ISO |
Carbachol results in increased expression of FOS protein Carbachol inhibits the reaction [APP protein modified form results in increased expression of FOS protein] |
CTD |
PMID:10404113 PMID:10758335 PMID:11074189 PMID:16023590 PMID:21295078 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gcg |
glucagon |
increases secretion multiple interactions |
ISO |
Carbachol results in increased secretion of GCG protein NPY protein inhibits the reaction [Carbachol results in increased secretion of GCG protein] |
CTD |
PMID:3329090 |
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NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929
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G |
Gna11 |
G protein subunit alpha 11 |
increases response to substance |
EXP |
GNA11 results in increased susceptibility to Carbachol |
CTD |
PMID:8014894 |
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NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812
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G |
Grm4 |
glutamate metabotropic receptor 4 |
multiple interactions |
ISO |
[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium; Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]; Pertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; tertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Tropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] |
CTD |
PMID:18171729 |
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NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821
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G |
Hdc |
histidine decarboxylase |
affects response to substance |
ISO |
HDC protein affects the susceptibility to Carbachol |
CTD |
PMID:12893847 |
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NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
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G |
Il10 |
interleukin 10 |
affects expression |
ISO |
Carbachol affects the expression of IL10 mRNA |
CTD |
PMID:15698499 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1b |
interleukin 1 beta |
affects expression increases expression |
EXP |
Carbachol affects the expression of IL1B protein Carbachol results in increased expression of IL1B protein |
CTD |
PMID:16023590 PMID:21121909 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il4 |
interleukin 4 |
increases expression |
ISO |
Carbachol results in increased expression of IL4 mRNA |
CTD |
PMID:15698499 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Ins1 |
insulin 1 |
multiple interactions increases secretion |
ISO EXP |
[Carbachol co-treated with Glucose] results in increased secretion of INS1 protein Sirolimus inhibits the reaction [Carbachol results in increased secretion of INS1 protein] |
CTD |
PMID:14578291 PMID:30761839 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
affects response to substance |
ISO |
KCNH2 protein mutant form affects the susceptibility to Carbachol |
CTD |
PMID:29574456 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Kcnj3 |
potassium inwardly-rectifying channel, subfamily J, member 3 |
multiple interactions |
ISO |
[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium; Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]; Pertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; tertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Tropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] |
CTD |
PMID:18171729 |
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NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
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G |
Lyz2 |
lysozyme 2 |
affects secretion |
ISO |
Carbachol affects the secretion of LYZ protein |
CTD |
PMID:15234967 |
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NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases activity decreases phosphorylation |
EXP ISO |
Calcium deficiency inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; calphostin C inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein] Carbachol results in increased activity of MAPK1 protein Carbachol results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:9121362 PMID:16877402 PMID:17008368 PMID:19002953 PMID:19017493 PMID:19200344 More...
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation increases activity |
EXP ISO |
Calcium deficiency inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; calphostin C inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein] Carbachol results in decreased phosphorylation of MAPK3 protein Carbachol results in increased activity of MAPK3 protein |
CTD |
PMID:9121362 PMID:16877402 PMID:17008368 PMID:19002953 PMID:19017493 PMID:19200344 More...
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Myl9 |
myosin light chain 9 |
increases phosphorylation |
EXP |
Carbachol results in increased phosphorylation of MYL9 protein |
CTD |
PMID:17272850 |
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NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
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G |
Mylk |
myosin light chain kinase |
affects response to substance |
EXP |
MYLK protein affects the susceptibility to Carbachol |
CTD |
PMID:17272850 |
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NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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G |
Npy |
neuropeptide Y |
multiple interactions |
ISO |
NPY protein inhibits the reaction [Carbachol results in increased secretion of GCG protein] |
CTD |
PMID:3329090 |
|
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
increases expression multiple interactions |
EXP |
Carbachol results in increased expression of NR4A1 mRNA Tetradecanoylphorbol Acetate inhibits the reaction [Carbachol results in increased expression of NR4A1 mRNA] |
CTD |
PMID:2005087 |
|
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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G |
Plcb1 |
phospholipase C beta 1 |
multiple interactions |
EXP |
PLCB1 protein inhibits the reaction [Carbachol results in increased abundance of Inositol Phosphates] |
CTD |
PMID:11377826 |
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NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
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G |
Prkcz |
protein kinase C, zeta |
multiple interactions increases activity |
ISO |
1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein]; Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein Carbachol results in increased activity of PRKCZ protein |
CTD |
PMID:15255942 |
|
NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
affects expression |
EXP |
Carbachol affects the expression of PTGS2 protein |
CTD |
PMID:16023590 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptk2b |
protein tyrosine kinase 2 beta |
multiple interactions |
EXP |
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]; Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein; Egtazic Acid inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein] |
CTD |
PMID:16877402 |
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NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions |
ISO |
1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Carbachol results in increased phosphorylation of and results in increased activity of RPS6KB1 protein |
CTD |
PMID:15255942 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Sct |
secretin |
decreases activity |
EXP |
SCT protein results in decreased activity of Carbachol |
CTD |
PMID:10198350 |
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NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658
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G |
Slc9a1 |
solute carrier family 9 member A1 |
increases activity |
ISO |
Carbachol results in increased activity of SLC9A1 protein |
CTD |
PMID:12842825 |
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NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
EXP |
Carbachol results in increased phosphorylation of and results in increased activity of SRC protein; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein] |
CTD |
PMID:16877402 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Tnf |
tumor necrosis factor |
increases expression affects expression multiple interactions decreases expression increases activity |
EXP ISO |
Carbachol results in increased expression of TNF protein Carbachol affects the expression of TNF protein TNF protein inhibits the reaction [Carbachol results in increased abundance of Phosphatidic Acids]; TNF protein inhibits the reaction [Carbachol results in increased abundance of phosphatidylbutanol] Carbachol results in decreased expression of TNF mRNA TNF results in increased activity of Carbachol |
CTD |
PMID:11245595 PMID:15086448 PMID:15698499 PMID:16023590 PMID:21121909 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
Carbachol inhibits the reaction [APP protein modified form results in increased expression of TRP53 protein] |
CTD |
PMID:10758335 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Trpc1 |
transient receptor potential cation channel, subfamily C, member 1 |
increases activity |
ISO |
Carbachol results in increased activity of TRPC1 protein |
CTD |
PMID:19289841 |
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NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276
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G |
Trpc2 |
transient receptor potential cation channel subfamily C member 2 |
increases activity |
ISO |
Carbachol results in increased activity of TRPC2 protein |
CTD |
PMID:19289841 |
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NCBI chr 1:156,460,009...156,473,039
Ensembl chr 1:156,440,305...156,473,073
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G |
Trpc3 |
transient receptor potential cation channel, subfamily C, member 3 |
multiple interactions increases activity |
ISO |
ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Carbachol results in increased activity of TRPC3 protein] |
CTD |
PMID:19289841 |
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NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855
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G |
Trpc4 |
transient receptor potential cation channel, subfamily C, member 4 |
multiple interactions increases activity increases response to substance |
ISO |
TRPC4 protein affects the reaction [Carbachol results in increased transport of Barium]; TRPC4 protein affects the reaction [Carbachol results in increased transport of Calcium] Carbachol results in increased activity of TRPC4 protein TRPC4 protein results in increased susceptibility to Carbachol |
CTD |
PMID:11830588 PMID:19289841 PMID:29658714 |
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NCBI chr 2:138,307,676...138,476,856
Ensembl chr 2:138,308,084...138,476,768
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G |
Trpc5 |
transient receptor potential cation channel, subfamily C, member 5 |
multiple interactions |
ISO |
Carbachol promotes the reaction [TRPC5 protein results in increased transport of Calcium]; resveratrol inhibits the reaction [Carbachol promotes the reaction [TRPC5 protein results in increased transport of Calcium]] |
CTD |
PMID:21127073 |
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NCBI chr X:107,946,163...108,230,991
Ensembl chr X:107,939,131...108,230,991
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G |
Trpc6 |
transient receptor potential cation channel, subfamily C, member 6 |
multiple interactions increases activity |
ISO |
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased activity of TRPC6 protein] |
CTD |
PMID:17603544 |
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NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
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