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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(-)-anisomycin
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Accession:CHEBI:338412 term browser browse the term
Definition:An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Synonyms:exact_synonym: (2R,3S,4S)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate
 related_synonym: 1,4,5-Trideoxy-1,4-imino-5-(p-methoxyphenyl)-D-xylo-pentitol 3-acetate;   2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate;   2-p-Methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine;   Formula=C14H19NO4;   InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1;   InChIKey=YKJYKKNCCRKFSL-RDBSUJKOSA-N;   SMILES=COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1
 alt_id: CHEBI:2737;   CHEBI:40748
 xref: Beilstein:20705;   CAS:22862-76-6;   DrugBank:DB07374;   KEGG:C11281;   LINCS:LSM-4047
 xref_mesh: MESH:D000841
 xref: PDBeChem:ANM;   PMID:16005213;   PMID:22004851;   PMID:23192275;   PMID:23525555;   PMID:23582782;   PMID:24333448;   PMID:6834379;   Reaxys:20705;   Wikipedia:Anisomycin


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(-)-anisomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions		 ISO Anisomycin results in increased expression of ABCC3 mRNA
SB 203580 inhibits the reaction [Anisomycin results in increased expression of ABCC3 mRNA]		 CTD PMID:27507784 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Anisomycin results in increased expression of AGER protein CTD PMID:33075463 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 increases phosphorylation ISO Anisomycin results in increased phosphorylation of AGO2 protein CTD PMID:18476811 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
decreases expression		 ISO Anisomycin promotes the reaction [Tetrachlorodibenzodioxin results in increased degradation of and results in decreased expression of AHR protein]
Anisomycin results in decreased expression of AHR protein		 CTD PMID:15385644 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression ISO anisomycin decreases expression of Arc protein in dorsal striatum RGD PMID:27567310 RGD:401901591 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Atf1 activating transcription factor 1 increases phosphorylation
multiple interactions		 ISO Anisomycin results in increased phosphorylation of ATF1 protein
[SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]; SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]		 CTD PMID:12660819 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670 		JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation
multiple interactions		 ISO Anisomycin results in increased phosphorylation of ATF2 protein
pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]; SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]		 CTD PMID:12663670 PMID:28975372 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression		 ISO [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of ATF3 mRNA] CTD PMID:19101521 PMID:22003189 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atg13 autophagy related 13 decreases expression ISO Anisomycin results in decreased expression of ATG13 protein CTD PMID:27629431 NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043 		JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase decreases expression ISO Anisomycin results in decreased expression of ATG4B protein CTD PMID:27629431 NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103 		JBrowse link
G Bach2 BTB domain and CNC homolog 2 increases expression ISO Anisomycin results in increased expression of BACH2 mRNA CTD PMID:24247028 NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Anisomycin promotes the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein] CTD PMID:33684387 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Colistin co-treated with Anisomycin] results in increased phosphorylation of BCL2 protein CTD PMID:28842171 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 multiple interactions EXP Anisomycin promotes the reaction [Colistin results in increased expression of BECN1 protein] CTD PMID:28842171 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Anisomycin results in increased cleavage of and results in increased activity of BID protein CTD PMID:18241849 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Anisomycin promotes the reaction [(+)-JQ1 compound results in decreased expression of BIRC5 protein] CTD PMID:23872705 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO
EXP		 Anisomycin promotes the reaction [Indomethacin results in increased activity of CASP3 protein]; Anisomycin results in increased cleavage of and results in increased activity of CASP3 protein
[Colistin co-treated with Anisomycin] results in increased cleavage of CASP3 protein; Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]
Anisomycin results in increased expression of CASP3 protein modified form
Anisomycin promotes the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]		 CTD PMID:17341418 PMID:18241849 PMID:28842171 PMID:29944914 PMID:33684387 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 multiple interactions ISO Anisomycin promotes the reaction [Indomethacin results in increased activity of CASP6 protein] CTD PMID:17341418 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp8 caspase 8 increases activity ISO Anisomycin results in increased activity of CASP8 protein CTD PMID:18241849 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP		 Anisomycin promotes the reaction [Indomethacin results in increased activity of CASP9 protein]
Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein]]		 CTD PMID:17341418 PMID:34767868 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cav1 caveolin 1 multiple interactions
increases phosphorylation		 ISO wogonin inhibits the reaction [Anisomycin results in increased phosphorylation of CAV1 protein] CTD PMID:23246481 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Anisomycin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Anisomycin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Anisomycin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO Anisomycin results in increased expression of CD55 mRNA CTD PMID:24247028 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd69 Cd69 molecule increases expression ISO Anisomycin results in increased expression of CD69 mRNA CTD PMID:24247028 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions		 ISO Anisomycin results in increased phosphorylation of CREB1 protein
SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of CREB1 protein]		 CTD PMID:12660819 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crebbp CREB binding protein increases expression ISO Anisomycin results in increased expression of CREBBP mRNA CTD PMID:24247028 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Cs citrate synthase multiple interactions ISO Anisomycin affects the reaction [triethylene glycol dimethacrylate affects the activity of CS protein] CTD PMID:33684387 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
increases expression		 ISO [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA] CTD PMID:22003189 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions		 ISO Anisomycin results in increased expression of CXCL1 mRNA
[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA]		 CTD PMID:22003189 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO Anisomycin results in increased expression of CYP1A1 mRNA
[Anisomycin co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA		 CTD PMID:15385644 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions ISO Anisomycin inhibits the reaction [Tretinoin results in increased expression of CYP26A1 mRNA] CTD PMID:16038797 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2A7 mRNA]; [Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2A7 mRNA CTD PMID:23539296 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA
Anisomycin promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA]		 CTD PMID:23539296 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Anisomycin results in increased expression of DDIT3 mRNA CTD PMID:18241849 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO Anisomycin results in decreased expression of DUSP6 mRNA CTD PMID:24247028 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Dusp8 dual specificity phosphatase 8 multiple interactions ISO DUSP8 protein inhibits the reaction [Anisomycin results in increased phosphorylation of JUN protein]; DUSP8 protein inhibits the reaction [Anisomycin results in increased phosphorylation of NR3C1 protein] CTD PMID:32780722 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921 		JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression		 ISO SB 203580 inhibits the reaction [Anisomycin results in increased expression of EGR1 mRNA] CTD PMID:9671412 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation
multiple interactions		 ISO Anisomycin results in increased phosphorylation of EIF4E protein
SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]		 CTD PMID:9545260 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Elk1 ETS transcription factor ELK1 increases phosphorylation
multiple interactions		 ISO Anisomycin results in increased phosphorylation of ELK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]; pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]		 CTD PMID:12660819 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO Anisomycin results in increased expression of EVI2A mRNA CTD PMID:24247028 NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843 		JBrowse link
G Fas Fas cell surface death receptor increases localization ISO Anisomycin results in increased localization of FAS protein CTD PMID:18241849 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Anisomycin results in increased expression of FOS mRNA CTD PMID:12660819 PMID:18241849 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Anisomycin results in increased expression of FOSB mRNA CTD PMID:18241849 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO Anisomycin inhibits the reaction [GHRL protein inhibits the reaction [Uranium results in decreased expression of and results in decreased secretion of TNFRSF11B protein]]; Anisomycin inhibits the reaction [GHRL protein inhibits the reaction [Uranium results in increased expression of and results in increased secretion of TNFSF11 protein]] CTD PMID:29477364 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Hoxa1 homeobox A1 multiple interactions ISO Anisomycin promotes the reaction [Tretinoin results in increased expression of HOXA1 mRNA] CTD PMID:16038797 NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Anisomycin results in decreased expression of HSPA5 mRNA; Anisomycin results in decreased expression of HSPA5 protein CTD PMID:25324550 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP Anisomycin inhibits the reaction [Cocaine results in increased expression of HSPA9 protein] CTD PMID:12422371 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Anisomycin inhibits the reaction [TNF protein results in increased expression of and affects the localization of ICAM1 protein] CTD PMID:21448188 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Anisomycin promotes the reaction [IGF1 protein results in increased phosphorylation of JUN protein] CTD PMID:11278392 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO Anisomycin results in increased expression of IL1B protein
Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased expression of IL1B protein]]		 CTD PMID:15019843 PMID:36928891 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased expression of IL6 protein]] CTD PMID:36928891 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Anisomycin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
increases phosphorylation		 ISO
EXP		 Anisomycin promotes the reaction [IGF1 protein results in increased phosphorylation of JUN protein]; DUSP8 protein inhibits the reaction [Anisomycin results in increased phosphorylation of JUN protein]
Anisomycin results in increased expression of JUN mRNA		 CTD PMID:9751194 PMID:11278392 PMID:15019843 PMID:18241849 PMID:21815634 More... NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO Anisomycin results in increased expression of JUND mRNA CTD PMID:18241849 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Anisomycin results in increased expression of MAFF mRNA CTD PMID:24247028 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 multiple interactions ISO MAP3K20 protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; quinoline analog inhibits the reaction [MAP3K20 protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]] CTD PMID:15737997 NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
increases expression		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK1 protein]; Anisomycin promotes the reaction [thymoquinone results in increased phosphorylation of MAPK1 protein]
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [Anisomycin results in increased phosphorylation of MAPK1 protein]
Anisomycin results in increased activity of MAPK1 protein
Anisomycin results in increased expression of MAPK1 protein modified form		 CTD PMID:9671412 PMID:11551972 PMID:12660819 PMID:15772366 PMID:25233930 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions
increases activity		 ISO Dicumarol inhibits the reaction [Anisomycin results in increased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
increases phosphorylation		 ISO
EXP		 Anisomycin results in increased phosphorylation of and results in increased activity of MAPK14 protein
MAPK14 protein affects the reaction [Anisomycin results in increased activity of MAPKAPK2 protein]
Anisomycin results in increased phosphorylation of MAPK14 protein		 CTD PMID:10704466 PMID:15961565 PMID:16038797 PMID:16364386 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
increases expression		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK3 protein]; Anisomycin promotes the reaction [thymoquinone results in increased phosphorylation of MAPK3 protein]
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK3 protein]
Anisomycin results in increased expression of MAPK3 protein modified form		 CTD PMID:12660819 PMID:15772366 PMID:25233930 PMID:34173702 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
increases activity		 ISO
EXP		 Anisomycin results in increased phosphorylation of MAPK8 protein
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK8 protein]
Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein
Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]]; Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein; MAP3K20 protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; quinoline analog inhibits the reaction [MAP3K20 protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]]
Anisomycin results in increased activity of MAPK8 protein		 CTD PMID:12902192 PMID:12967334 PMID:15737997 PMID:15772366 PMID:15961565 More... NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 ISO 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK9 protein] CTD PMID:12967334 PMID:15772366 PMID:16038797 PMID:33075463 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases activity
multiple interactions		 ISO Anisomycin results in increased activity of MAPKAPK2 protein
MAPK14 protein affects the reaction [Anisomycin results in increased activity of MAPKAPK2 protein]		 CTD PMID:10704466 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457 		JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 increases activity
multiple interactions		 ISO Anisomycin results in increased activity of MKNK1 protein
SB 203580 inhibits the reaction [Anisomycin results in increased activity of MKNK1 protein]		 CTD PMID:9545260 NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639 		JBrowse link
G Mrps30 mitochondrial ribosomal protein S30 increases expression ISO Anisomycin results in increased expression of MRPS30 mRNA CTD PMID:24247028 NCBI chr 2:50,456,253...50,463,128
Ensembl chr 2:50,456,255...50,463,105 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Anisomycin results in increased expression of MYC mRNA CTD PMID:24247028 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nefh neurofilament heavy chain decreases degradation EXP Anisomycin results in decreased degradation of NEFH mRNA CTD PMID:1280263 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nefl neurofilament light chain decreases degradation EXP Anisomycin results in decreased degradation of NEFL mRNA CTD PMID:1280263 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nefm neurofilament medium chain decreases degradation EXP Anisomycin results in decreased degradation of NEFM mRNA CTD PMID:1280263 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 multiple interactions ISO [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of ATF3 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL8 mRNA] CTD PMID:22003189 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2A7 mRNA]; [Anisomycin co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2C9 mRNA; [Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2A7 mRNA; Anisomycin promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA]
[6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA		 CTD PMID:23539296 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases phosphorylation
multiple interactions		 ISO Anisomycin results in increased phosphorylation of NR3C1 protein
DUSP8 protein inhibits the reaction [Anisomycin results in increased phosphorylation of NR3C1 protein]		 CTD PMID:32780722 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP [Colistin co-treated with Anisomycin] results in increased cleavage of PARP1 protein; Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]] CTD PMID:28842171 PMID:34767868 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Anisomycin results in increased expression of PMAIP1 mRNA CTD PMID:24247028 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Postn periostin increases expression EXP Anisomycin results in increased expression of POSTN mRNA CTD PMID:15121739 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 multiple interactions EXP Anisomycin inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein] CTD PMID:17623046 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882 		JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions ISO Anisomycin promotes the reaction [Tretinoin results in increased expression of RARB mRNA] CTD PMID:16038797 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Ret ret proto-oncogene decreases expression EXP Anisomycin results in decreased expression of RET protein CTD PMID:17555550 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Rhoh ras homolog family member H increases expression ISO Anisomycin results in increased expression of RHOH mRNA CTD PMID:24247028 NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369 		JBrowse link
G Rora RAR-related orphan receptor A increases expression ISO Anisomycin results in increased expression of RORA mRNA CTD PMID:24247028 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Rxra retinoid X receptor alpha increases phosphorylation
multiple interactions		 ISO Anisomycin results in increased phosphorylation of RXRA protein
pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of RXRA protein]		 CTD PMID:16038797 PMID:16184197 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP
ISO		 Anisomycin promotes the reaction [Colistin results in increased degradation of SQSTM1 protein]
Anisomycin promotes the reaction [triethylene glycol dimethacrylate results in increased expression of SQSTM1 protein]		 CTD PMID:28842171 PMID:33684387 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srf serum response factor increases phosphorylation
multiple interactions		 ISO Anisomycin results in increased phosphorylation of SRF protein
SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of SRF protein]		 CTD PMID:12660819 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Anisomycin promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]; Anisomycin results in increased expression of and results in increased stability of STAR mRNA CTD PMID:15713539 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Anisomycin results in increased expression of TNF mRNA
Anisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased expression of TNF protein]]; Anisomycin inhibits the reaction [TNF protein results in increased expression of and affects the localization of ICAM1 protein]		 CTD PMID:18241849 PMID:21448188 PMID:36928891 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions ISO Anisomycin inhibits the reaction [GHRL protein inhibits the reaction [Uranium results in decreased expression of and results in decreased secretion of TNFRSF11B protein]] CTD PMID:29477364 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Anisomycin inhibits the reaction [GHRL protein inhibits the reaction [Uranium results in increased expression of and results in increased secretion of TNFSF11 protein]] CTD PMID:29477364 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression
decreases expression		 ISO Anisomycin results in increased expression of TNFSF9 mRNA
Anisomycin results in decreased expression of TNFSF9 mRNA		 CTD PMID:18241849 PMID:24247028 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Anisomycin promotes the reaction [Colistin results in increased expression of TP53 protein] CTD PMID:28842171 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Anisomycin results in increased expression of TXNIP mRNA CTD PMID:10843682 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 decreases expression ISO Anisomycin results in decreased expression of ULK1 protein CTD PMID:27629431 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
G Usp30 ubiquitin specific peptidase 30 increases expression ISO Anisomycin results in increased expression of USP30 mRNA CTD PMID:24247028 NCBI chr12:42,501,345...42,555,311
Ensembl chr12:42,501,348...42,555,616 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Anisomycin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xbp1 X-box binding protein 1 decreases splicing ISO Anisomycin results in decreased splicing of XBP1 mRNA CTD PMID:25324550 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        antimicrobial agent 18266
          (-)-anisomycin 96
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic heterocyclic compound 18870
                                  organic heteromonocyclic compound 17791
                                    pyrrolidines 2333
                                      hydroxypyrrolidine 96
                                        monohydroxypyrrolidine 96
                                          (-)-anisomycin 96
paths to the root