macromolecule - Ontology Report - Rat Genome Database

INS protein results in increased abundance of Adrenocorticotropic Hormone

PMID:1646414

NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122

lipopolysaccharide

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

HSD11B1

hydroxysteroid 11-beta dehydrogenase 1

increases expression

Lipopolysaccharides results in increased expression of HSD11B1 mRNA

PMID:21798686

NCBI chr 7:8,344,380...8,409,901
Ensembl chr 7:8,344,447...8,409,897

HSP70

heat shock protein 70

multiple interactions

HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]

NCBI chr12:1,285,282...1,287,670

IL1B

interleukin 1 beta

multiple interactions
increases expression

arsenite affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

IL6

interleukin 6

multiple interactions
increases expression

arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

RELA

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases phosphorylation

arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]

NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875

TNF

tumor necrosis factor

multiple interactions
increases expression

arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

mastoparan

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

GNAQ

G protein subunit alpha q

multiple interactions

G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; mastoparan results in increased activity of and affects the localization of GNAQ protein

PMID:21671308

NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065

HEXB

hexosaminidase subunit beta

multiple interactions
increases secretion

G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; Pertussis Toxin inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein]; YM-254890 inhibits the reaction [mastoparan results in increased secretion of HEXB protein]

PMID:21671308

NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417

melittin

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

HEXB

hexosaminidase subunit beta

multiple interactions
increases secretion

G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; sialogangliosides inhibits the reaction [Melitten results in increased secretion of HEXB protein]; trisialoganglioside GT1 inhibits the reaction [Melitten results in increased secretion of HEXB protein]

PMID:21334356

NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417

methyl beta-cyclodextrin

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

HEXB

hexosaminidase subunit beta

multiple interactions

methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein]