|
G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
multiple interactions |
EXP |
[Beryllium results in increased methylation of CDKN2A promoter] which results in decreased expression of CDKN2A mRNA |
CTD |
PMID:11872642 |
|
NCBI chr 5:109,100,763...109,114,448
|
|
G |
Esr1 |
estrogen receptor 1 |
increases methylation |
EXP |
Beryllium results in increased methylation of ESR1 gene |
CTD |
PMID:11872642 |
|
NCBI chr 1:43,511,685...43,904,454
|
|
G |
Hras |
HRas proto-oncogene, GTPase |
increases mutagenesis |
EXP |
Beryllium results in increased mutagenesis of HRAS gene |
CTD |
PMID:7545909 |
|
NCBI chr 1:205,712,625...205,729,406
|
|
G |
Il1b |
interleukin 1 beta |
increases expression affects expression |
ISO |
Beryllium results in increased expression of IL1B mRNA Beryllium affects the expression of IL1B mRNA |
CTD |
PMID:8473757 PMID:8629860 |
|
NCBI chr 3:137,030,200...137,036,581
|
|
G |
RT1-Hb-ps1 |
RT1 class II, locus Hb, pseudogene 1 |
affects binding increases response to substance |
ISO |
HLA-DPB1 protein mutant form binds to Beryllium HLA-DPB1 gene polymorphism results in increased susceptibility to Beryllium; HLA-DPB1 gene SNP results in increased susceptibility to Beryllium; HLA-DPB1 protein mutant form results in increased susceptibility to Beryllium |
CTD |
PMID:11551429 PMID:15273960 PMID:17956852 |
|
NCBI chr20:4,775,598...4,779,590
|
|
G |
Tnf |
tumor necrosis factor |
increases expression increases secretion increases response to substance |
ISO |
Beryllium results in increased expression of TNF mRNA Beryllium results in increased secretion of TNF protein TNF promoter polymorphism results in increased susceptibility to Beryllium |
CTD |
PMID:8629860 PMID:12449171 PMID:15127972 |
|
NCBI chr20:3,626,685...3,629,303
|
|
|
G |
Pdxp |
pyridoxal phosphatase |
decreases activity |
ISO |
beryllium trifluoride results in decreased activity of PDXP protein |
CTD |
PMID:24338473 |
|
NCBI chr 7:110,472,515...110,477,963
|
|
G |
Pgp |
phosphoglycolate phosphatase |
decreases activity |
ISO |
beryllium trifluoride results in decreased activity of PGP protein |
CTD |
PMID:24338473 |
|
NCBI chr10:13,999,782...14,002,408
|
|