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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:beryllium molecular entity
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Accession:CHEBI:33780 term browser browse the term
Synonyms:related_synonym: beryllium compounds;   beryllium molecular entities


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beryllium dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 affects expression ISO beryllium chloride affects the expression of APEX1 mRNA CTD PMID:23793613 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase affects expression ISO beryllium chloride affects the expression of OGG1 mRNA CTD PMID:23793613 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO beryllium chloride results in increased expression of TRP53 mRNA CTD PMID:23793613 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
beryllium difluoride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO beryllium fluoride promotes the reaction [ABCB1 protein mutant form binds to 8-azidoadenosine 5'-triphosphate] CTD PMID:11027628 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions EXP beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]; Cobalt promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]; Magnesium Chloride promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]; Manganese promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]; Nickel promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]] CTD PMID:12069597 NCBI chr 1:105,583,681...105,637,895
Ensembl chr 1:105,583,682...105,637,895 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 decreases activity ISO
EXP 		beryllium fluoride results in decreased activity of ABCC8 protein CTD PMID:17561960 PMID:18025464 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO beryllium fluoride results in increased expression of CREB1 protein CTD PMID:11867686 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO beryllium fluoride results in increased expression of FOS protein CTD PMID:11867686 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases phosphorylation ISO beryllium fluoride results in increased phosphorylation of MAP2K1 protein CTD PMID:11867686 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO beryllium fluoride results in increased phosphorylation of MAPK3 protein CTD PMID:11867686 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO beryllium fluoride results in increased expression of MYC protein CTD PMID:11867686 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
beryllium dihydride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP [Beryllium results in increased methylation of CDKN2A promoter] which results in decreased expression of CDKN2A mRNA CTD PMID:11872642 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Esr1 estrogen receptor 1 increases methylation EXP Beryllium results in increased methylation of ESR1 gene CTD PMID:11872642 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases mutagenesis EXP Beryllium results in increased mutagenesis of HRAS gene CTD PMID:7545909 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Il1b interleukin 1 beta increases expression
affects expression 		ISO Beryllium results in increased expression of IL1B mRNA
Beryllium affects the expression of IL1B mRNA 		CTD PMID:8473757 PMID:8629860 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G RT1-Hb-ps1 RT1 class II, locus Hb, pseudogene 1 affects binding
increases response to substance 		ISO HLA-DPB1 protein mutant form binds to Beryllium
HLA-DPB1 gene polymorphism results in increased susceptibility to Beryllium; HLA-DPB1 gene SNP results in increased susceptibility to Beryllium; HLA-DPB1 protein mutant form results in increased susceptibility to Beryllium 		CTD PMID:11551429 PMID:15273960 PMID:17956852 NCBI chr20:4,777,494...4,781,486
Ensembl chr20:4,776,547...4,781,574 		JBrowse link
G Tnf tumor necrosis factor increases expression
increases response to substance
increases secretion 		ISO Beryllium results in increased expression of TNF mRNA
TNF promoter polymorphism results in increased susceptibility to Beryllium
Beryllium results in increased secretion of TNF protein 		CTD PMID:8629860 PMID:12449171 PMID:15127972 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
beryllium sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions
increases expression 		ISO [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in increased expression of ACSL4 mRNA]; Deferoxamine inhibits the reaction [beryllium sulfate results in increased expression of ACSL4 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in increased expression of ACSL4 mRNA] CTD PMID:36843388 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:110,739,648...110,803,261 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO beryllium sulfate results in increased expression of ACTA2 mRNA CTD PMID:16314022 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Amot angiomotin decreases expression ISO beryllium sulfate results in decreased expression of AMOT mRNA CTD PMID:35679967 NCBI chr  X:113,778,990...113,837,846
Ensembl chr  X:113,781,526...113,837,482 		JBrowse link
G Anxa5 annexin A5 increases expression ISO beryllium sulfate results in increased expression of ANXA5 mRNA CTD PMID:16314022 NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400 		JBrowse link
G Arhgap26 Rho GTPase activating protein 26 increases expression
decreases expression 		ISO beryllium sulfate results in increased expression of ARHGAP26 mRNA
beryllium sulfate results in decreased expression of ARHGAP26 mRNA 		CTD PMID:35679967 NCBI chr18:30,702,602...31,489,047
Ensembl chr18:31,089,787...31,489,047 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
increases secretion 		ISO beryllium sulfate promotes the reaction [RUNX1 protein binds to CCL3 promoter]
beryllium sulfate results in increased secretion of CCL3 mRNA 		CTD PMID:16314022 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion ISO beryllium sulfate results in increased secretion of CCL4 mRNA CTD PMID:16314022 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO beryllium sulfate results in increased expression of CCL5 mRNA CTD PMID:16314022 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Ccnt1 cyclin T1 increases expression ISO beryllium sulfate results in increased expression of CCNT1 mRNA CTD PMID:35679967 NCBI chr 7:131,566,176...131,596,988
Ensembl chr 7:131,566,176...131,596,938 		JBrowse link
G Cd44 CD44 molecule increases expression ISO beryllium sulfate results in increased expression of CD44 mRNA CTD PMID:16314022 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424 		JBrowse link
G Cd86 CD86 molecule increases expression ISO beryllium sulfate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression 		ISO beryllium sulfate promotes the reaction [TP53 protein binds to CDKN1A promoter]
beryllium sulfate results in increased expression of CDKN1A mRNA; beryllium sulfate results in increased expression of CDKN1A protein 		CTD PMID:17395767 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO beryllium sulfate results in increased expression of CDKN2A mRNA; beryllium sulfate results in increased expression of CDKN2A protein CTD PMID:17395767 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Cgas cyclic GMP-AMP synthase increases expression ISO beryllium sulfate results in increased expression of CGAS mRNA CTD PMID:38778435 NCBI chr 8:88,172,559...88,187,538
Ensembl chr 8:88,174,512...88,185,859 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [beryllium sulfate co-treated with IFNG protein] results in increased expression of CREB1 protein CTD PMID:10755711 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Cryaa crystallin, alpha A decreases expression ISO beryllium sulfate results in decreased expression of CRYAA mRNA CTD PMID:35679967 NCBI chr20:9,784,872...9,788,656
Ensembl chr20:9,784,857...9,788,654 		JBrowse link
G Ctsl cathepsin L increases expression ISO beryllium sulfate results in increased expression of CTSL mRNA CTD PMID:16314022 NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113 		JBrowse link
G Cul9 cullin 9 increases expression
decreases expression 		ISO beryllium sulfate results in increased expression of CUL9 mRNA
beryllium sulfate results in decreased expression of CUL9 mRNA 		CTD PMID:35679967 NCBI chr 9:14,435,948...14,479,552
Ensembl chr 9:21,933,803...21,977,145 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases secretion ISO beryllium sulfate results in increased secretion of CXCL1 mRNA CTD PMID:16314022 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases secretion ISO beryllium sulfate results in increased secretion of CXCL1 mRNA CTD PMID:16314022 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Ddhd2 DDHD domain containing 2 increases expression ISO beryllium sulfate results in increased expression of DDHD2 mRNA CTD PMID:35679967 NCBI chr16:73,022,136...73,051,746
Ensembl chr16:73,022,193...73,051,745 		JBrowse link
G Egr2 early growth response 2 increases expression ISO beryllium sulfate results in increased expression of EGR2 mRNA CTD PMID:16314022 NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions 		ISO beryllium sulfate results in increased expression of FOS mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA] 		CTD PMID:11568973 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
decreases expression 		ISO [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in decreased expression of FTH1 mRNA]; [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in decreased expression of FTH1 protein]; Deferoxamine inhibits the reaction [beryllium sulfate results in decreased expression of FTH1 mRNA]; Deferoxamine inhibits the reaction [beryllium sulfate results in decreased expression of FTH1 protein]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of FTH1 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of FTH1 protein]
beryllium sulfate results in decreased expression of FTH1 mRNA; beryllium sulfate results in decreased expression of FTH1 protein 		CTD PMID:36843388 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases expression 		ISO [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in decreased expression of GPX4 mRNA]; Deferoxamine inhibits the reaction [beryllium sulfate results in decreased expression of GPX4 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of GPX4 mRNA] CTD PMID:36843388 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 increases expression ISO beryllium sulfate results in increased expression of HNRNPA1 mRNA CTD PMID:16314022 NCBI chr 7:136,253,633...136,260,085
Ensembl chr 7:136,253,278...136,260,085 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases secretion
increases expression 		ISO 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [beryllium sulfate results in increased expression of ICAM1 mRNA]; 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [beryllium sulfate results in increased secretion of ICAM1 protein]; Dimethyl Sulfoxide inhibits the reaction [beryllium sulfate results in increased secretion of ICAM1 protein]
beryllium sulfate results in increased expression of ICAM1 mRNA; beryllium sulfate results in increased expression of ICAM1 protein 		CTD PMID:18539414 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions
increases expression 		ISO STING1 protein promotes the reaction [beryllium sulfate results in increased expression of IFNB1 mRNA]; STING1 protein promotes the reaction [beryllium sulfate results in increased expression of IFNB1 protein]
beryllium sulfate results in increased expression of IFNB1 mRNA; beryllium sulfate results in increased expression of IFNB1 protein 		CTD PMID:38778435 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487 		JBrowse link
G Ifng interferon gamma increases expression
multiple interactions 		ISO beryllium sulfate results in increased expression of IFNG protein
[beryllium sulfate co-treated with IFNG protein] results in increased expression of CREB1 protein; [beryllium sulfate co-treated with IFNG protein] results in increased expression of JUN protein; [beryllium sulfate co-treated with IFNG protein] results in increased expression of JUNB protein; [beryllium sulfate co-treated with IFNG protein] results in increased expression of NFKB1 protein; beryllium sulfate promotes the reaction [IFNG protein results in increased expression of TNF protein] 		CTD PMID:10755710 PMID:10755711 PMID:20974702 PMID:33197057 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions 		ISO beryllium sulfate results in increased expression of IL10 mRNA; beryllium sulfate results in increased expression of IL10 protein
STING1 protein promotes the reaction [beryllium sulfate results in increased expression of IL10 mRNA]; STING1 protein promotes the reaction [beryllium sulfate results in increased expression of IL10 protein] 		CTD PMID:33197057 PMID:38778435 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il18 interleukin 18 increases expression ISO beryllium sulfate results in increased expression of IL18 mRNA; beryllium sulfate results in increased expression of IL18 protein CTD PMID:16100009 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il2 interleukin 2 increases expression ISO beryllium sulfate results in increased expression of IL2 mRNA CTD PMID:9328138 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il5 interleukin 5 increases expression ISO beryllium sulfate results in increased expression of IL5 mRNA CTD PMID:9328138 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il6 interleukin 6 increases expression ISO beryllium sulfate results in increased expression of IL6 mRNA CTD PMID:9328138 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Itgb3 integrin subunit beta 3 increases expression ISO beryllium sulfate results in increased expression of ITGB3 mRNA CTD PMID:16314022 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression 		ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; [beryllium sulfate co-treated with IFNG protein] results in increased expression of JUN protein; Dactinomycin inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA] CTD PMID:10755711 PMID:11568973 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [beryllium sulfate co-treated with IFNG protein] results in increased expression of JUNB protein CTD PMID:10755711 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218 		JBrowse link
G Krt4 keratin 4 decreases expression ISO beryllium sulfate results in decreased expression of KRT4 mRNA CTD PMID:35679967 NCBI chr 7:134,924,753...134,931,050
Ensembl chr 7:134,924,753...134,930,713 		JBrowse link
G Mfsd14b major facilitator superfamily domain containing 14B decreases expression ISO beryllium sulfate results in decreased expression of MFSD14B mRNA CTD PMID:35679967 NCBI chr17:83,686...136,623
Ensembl chr17:83,762...136,514 		JBrowse link
G Mir1306 microRNA 1306 increases expression ISO beryllium sulfate results in increased expression of MIR1306 mRNA CTD PMID:33197057 NCBI chr11:96,213,960...96,214,032
Ensembl chr11:96,213,946...96,214,028 		JBrowse link
G Mir150 microRNA 150 increases expression ISO beryllium sulfate results in increased expression of MIR150 mRNA CTD PMID:33197057 NCBI chr 1:104,741,487...104,741,571
Ensembl chr 1:104,741,487...104,741,571 		JBrowse link
G Mir193b microRNA 193b increases expression ISO beryllium sulfate results in increased expression of MIR193B mRNA CTD PMID:33197057 NCBI chr10:1,824,944...1,825,026
Ensembl chr10:1,824,944...1,825,026 		JBrowse link
G Mir23b microRNA 23b decreases expression ISO beryllium sulfate results in decreased expression of MIR23B mRNA CTD PMID:33197057 NCBI chr17:1,819,386...1,819,482 JBrowse link
G Mir324 microRNA 324 increases expression ISO beryllium sulfate results in increased expression of MIR324 mRNA CTD PMID:33197057 NCBI chr10:55,233,363...55,233,445
Ensembl chr10:55,233,361...55,233,449 		JBrowse link
G Mir363 microRNA 363 increases expression ISO beryllium sulfate results in increased expression of MIR363 mRNA CTD PMID:33197057 NCBI chr  X:137,342,777...137,342,863 JBrowse link
G Mir484 microRNA 484 decreases expression ISO beryllium sulfate results in decreased expression of MIR484 mRNA CTD PMID:33197057 NCBI chr10:1,394,905...1,394,981 JBrowse link
G Mir504 microRNA 504 increases expression ISO beryllium sulfate results in increased expression of MIR504 mRNA CTD PMID:33197057 NCBI chr  X:142,354,419...142,354,495 JBrowse link
G Mir877 microRNA 877 increases expression ISO beryllium sulfate results in increased expression of MIR877 mRNA CTD PMID:33197057 NCBI chr20:2,816,284...2,816,368
Ensembl chr20:2,816,284...2,816,368 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP beryllium sulfate results in increased expression of MYC protein CTD PMID:2009323 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
increases expression 		ISO [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in increased expression of NCOA4 mRNA]; [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in increased expression of NCOA4 protein]; Deferoxamine inhibits the reaction [beryllium sulfate results in increased expression of NCOA4 mRNA]; Deferoxamine inhibits the reaction [beryllium sulfate results in increased expression of NCOA4 protein]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of FTH1 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of FTH1 protein]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of GPX4 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of SLC7A11 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in increased expression of ACSL4 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in increased expression of NCOA4 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in increased expression of NCOA4 protein]; NCOA4 protein affects the reaction [beryllium sulfate results in increased expression of PTGS2 mRNA]
beryllium sulfate results in increased expression of NCOA4 mRNA; beryllium sulfate results in increased expression of NCOA4 protein 		CTD PMID:36843388 NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,401,802...7,415,840 		JBrowse link
G Nedd8 NEDD8 ubiquitin like modifier increases expression ISO beryllium sulfate results in increased expression of NEDD8 mRNA CTD PMID:16314022 NCBI chr15:33,123,505...33,135,522
Ensembl chr15:33,123,505...33,135,522 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [beryllium sulfate co-treated with IFNG protein] results in increased expression of NFKB1 protein CTD PMID:10755711 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO beryllium sulfate results in increased expression of NOS2 protein CTD PMID:33197057 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nova1 NOVA alternative splicing regulator 1 increases expression ISO beryllium sulfate results in increased expression of NOVA1 mRNA CTD PMID:16314022 NCBI chr 6:69,506,983...69,632,437
Ensembl chr 6:69,506,983...69,632,437 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases expression ISO beryllium sulfate results in decreased expression of PDPK1 mRNA CTD PMID:35679967 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Phf19 PHD finger protein 19 decreases expression ISO beryllium sulfate results in decreased expression of PHF19 mRNA CTD PMID:35679967 NCBI chr 3:38,572,766...38,604,950
Ensembl chr 3:38,572,766...38,593,854 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions 		ISO beryllium sulfate results in increased expression of PTGS2 mRNA; beryllium sulfate results in increased expression of PTGS2 protein
[sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in increased expression of PTGS2 mRNA]; Deferoxamine inhibits the reaction [beryllium sulfate results in increased expression of PTGS2 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in increased expression of PTGS2 mRNA] 		CTD PMID:33197057 PMID:36843388 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rhoa ras homolog family member A increases expression ISO beryllium sulfate results in increased expression of RHOA mRNA CTD PMID:16314022 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Rpl22 ribosomal protein L22 increases expression ISO beryllium sulfate results in increased expression of RPL22 mRNA CTD PMID:16314022 NCBI chr 5:168,114,432...168,126,114
Ensembl chr 5:168,111,074...168,126,114
Ensembl chr 4:168,111,074...168,126,114
Ensembl chr 7:168,111,074...168,126,114 		JBrowse link
G Rpl30 ribosomal protein L30 increases expression ISO beryllium sulfate results in increased expression of RPL30 mRNA CTD PMID:16314022 NCBI chr 7:67,533,420...67,536,555
Ensembl chr 7:67,465,332...67,536,555 		JBrowse link
G Rpl37a ribosomal protein L37A increases expression ISO beryllium sulfate results in increased expression of RPL37A mRNA CTD PMID:16314022 NCBI chr 9:81,748,091...81,750,174
Ensembl chr 9:81,748,103...81,751,975 		JBrowse link
G Rps7 ribosomal protein S7 increases expression ISO beryllium sulfate results in increased expression of RPS7 mRNA CTD PMID:16314022 NCBI chr 6:50,994,581...50,999,447 JBrowse link
G RT1-CE16 RT1 class I, locus CE16 increases expression ISO beryllium sulfate results in increased expression of HLA-A mRNA CTD PMID:16314022 NCBI chr20:3,261,656...3,265,548 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases response to substance
increases expression 		ISO HLA-DRB1 protein mutant form results in increased susceptibility to beryllium sulfate
beryllium sulfate results in increased expression of HLA-DRB1 mRNA 		CTD PMID:16272364 PMID:16314022 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165 		JBrowse link
G RT1-Hb-ps1 RT1 class II, locus Hb, pseudogene 1 affects binding ISO beryllium sulfate binds to HLA-DPB1 protein CTD PMID:11423174 NCBI chr20:4,777,494...4,781,486
Ensembl chr20:4,776,547...4,781,574 		JBrowse link
G Runx1 RUNX family transcription factor 1 multiple interactions ISO beryllium sulfate promotes the reaction [RUNX1 protein binds to CCL3 promoter] CTD PMID:16314022 NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925 		JBrowse link
G Serpinb2 serpin family B member 2 increases expression ISO beryllium sulfate results in increased expression of SERPINB2 mRNA CTD PMID:16314022 NCBI chr13:24,051,933...24,065,032
Ensembl chr13:24,056,021...24,065,031 		JBrowse link
G Sftpd surfactant protein D increases expression ISO beryllium sulfate results in increased expression of SFTPD mRNA CTD PMID:16314022 NCBI chr16:17,080,575...17,093,047
Ensembl chr16:17,080,567...17,094,036 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions
decreases expression 		ISO [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in decreased expression of SLC7A11 mRNA]; Deferoxamine inhibits the reaction [beryllium sulfate results in decreased expression of SLC7A11 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of SLC7A11 mRNA] CTD PMID:36843388 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 multiple interactions
increases expression 		ISO STING1 protein promotes the reaction [beryllium sulfate results in increased expression of IFNB1 mRNA]; STING1 protein promotes the reaction [beryllium sulfate results in increased expression of IFNB1 protein]; STING1 protein promotes the reaction [beryllium sulfate results in increased expression of IL10 mRNA]; STING1 protein promotes the reaction [beryllium sulfate results in increased expression of IL10 protein]; STING1 protein promotes the reaction [beryllium sulfate results in increased expression of TFAM protein]; STING1 protein promotes the reaction [beryllium sulfate results in increased expression of TNF mRNA]; STING1 protein promotes the reaction [beryllium sulfate results in increased expression of TNF protein]; STING1 protein promotes the reaction [beryllium sulfate results in increased phosphorylation of TBK1 protein]
beryllium sulfate results in increased expression of STING1 mRNA; beryllium sulfate results in increased expression of STING1 protein 		CTD PMID:38778435 NCBI chr18:27,606,196...27,612,544
Ensembl chr18:27,606,196...27,611,947 		JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP beryllium sulfate inhibits the reaction [Hydrocortisone results in increased expression of TAT protein] CTD PMID:6120038 NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482 		JBrowse link
G Tbk1 TANK-binding kinase 1 multiple interactions
increases phosphorylation 		ISO STING1 protein promotes the reaction [beryllium sulfate results in increased phosphorylation of TBK1 protein] CTD PMID:38778435 NCBI chr 7:58,963,319...58,996,357
Ensembl chr 7:58,963,325...58,996,357 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions
increases expression 		ISO STING1 protein promotes the reaction [beryllium sulfate results in increased expression of TFAM protein] CTD PMID:38778435 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877 		JBrowse link
G Thsd7a thrombospondin type 1 domain containing 7A decreases expression
increases expression 		ISO beryllium sulfate results in decreased expression of THSD7A mRNA
beryllium sulfate results in increased expression of THSD7A mRNA 		CTD PMID:35679967 NCBI chr 4:41,427,276...41,865,524
Ensembl chr 4:41,426,275...41,865,723 		JBrowse link
G Tmsb4x thymosin beta 4, X-linked increases expression ISO beryllium sulfate results in increased expression of TMSB4X mRNA CTD PMID:16314022 NCBI chr  X:30,761,611...30,763,612
Ensembl chr  X:30,761,612...30,763,613 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions 		ISO beryllium sulfate results in increased expression of TNF mRNA; beryllium sulfate results in increased expression of TNF protein
STING1 protein promotes the reaction [beryllium sulfate results in increased expression of TNF mRNA]; STING1 protein promotes the reaction [beryllium sulfate results in increased expression of TNF protein]
beryllium sulfate promotes the reaction [IFNG protein results in increased expression of TNF protein] 		CTD PMID:10755710 PMID:10755711 PMID:33197057 PMID:38778435 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression 		ISO beryllium sulfate promotes the reaction [TP53 protein binds to CDKN1A promoter]
beryllium sulfate results in increased expression of TP53 protein 		CTD PMID:17395767 PMID:20974702 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Wnt4 Wnt family member 4 increases expression ISO beryllium sulfate results in increased expression of WNT4 mRNA CTD PMID:16314022 NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:154,797,311...154,817,128 		JBrowse link
G Zfp77 zinc finger protein 77 increases expression ISO beryllium sulfate results in increased expression of ZNF77 mRNA CTD PMID:16314022 NCBI chr 7:7,269,879...7,316,286
Ensembl chr 7:7,920,716...7,937,127 		JBrowse link
beryllium(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP [Beryllium results in increased methylation of CDKN2A promoter] which results in decreased expression of CDKN2A mRNA CTD PMID:11872642 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Esr1 estrogen receptor 1 increases methylation EXP Beryllium results in increased methylation of ESR1 gene CTD PMID:11872642 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases mutagenesis EXP Beryllium results in increased mutagenesis of HRAS gene CTD PMID:7545909 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Il1b interleukin 1 beta increases expression
affects expression 		ISO Beryllium results in increased expression of IL1B mRNA
Beryllium affects the expression of IL1B mRNA 		CTD PMID:8473757 PMID:8629860 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G RT1-Hb-ps1 RT1 class II, locus Hb, pseudogene 1 increases response to substance
affects binding 		ISO HLA-DPB1 gene polymorphism results in increased susceptibility to Beryllium; HLA-DPB1 gene SNP results in increased susceptibility to Beryllium; HLA-DPB1 protein mutant form results in increased susceptibility to Beryllium
HLA-DPB1 protein mutant form binds to Beryllium 		CTD PMID:11551429 PMID:15273960 PMID:17956852 NCBI chr20:4,777,494...4,781,486
Ensembl chr20:4,776,547...4,781,574 		JBrowse link
G Tnf tumor necrosis factor increases response to substance
increases secretion
increases expression 		ISO TNF promoter polymorphism results in increased susceptibility to Beryllium
Beryllium results in increased secretion of TNF protein
Beryllium results in increased expression of TNF mRNA 		CTD PMID:8629860 PMID:12449171 PMID:15127972 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
trifluoroberyllate(1-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxp pyridoxal phosphatase decreases activity ISO beryllium trifluoride results in decreased activity of PDXP protein CTD PMID:24338473 NCBI chr 7:112,352,971...112,358,419
Ensembl chr 7:112,352,726...112,358,419 		JBrowse link
G Pgp phosphoglycolate phosphatase decreases activity ISO beryllium trifluoride results in decreased activity of PGP protein CTD PMID:24338473 NCBI chr10:13,999,782...14,002,408
Ensembl chr10:13,999,331...14,002,408 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        epitope 7059
          beryllium atom 91
            beryllium molecular entity 91
              beryllium coordination entity + 8
              beryllium dichloride 3
              beryllium difluoride 8
              beryllium oxide 0
              elemental beryllium + 82
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        alkaline earth molecular entity 916
                          beryllium molecular entity 91
                            beryllium coordination entity + 8
                            beryllium dichloride 3
                            beryllium difluoride 8
                            beryllium oxide 0
                            elemental beryllium + 82
paths to the root