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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:organic aromatic compound
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Accession:CHEBI:33659 term browser browse the term
Synonyms:related_synonym: organic aromatic compounds



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(-)-epigallocatechin 3-gallate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [[alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [alpha-naphthoflavone results in increased activity of AHR protein] CTD PMID:12970578 PMID:22521609 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions
decreases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]
epigallocatechin gallate results in decreased expression of CCL2 mRNA
CTD PMID:20580034 PMID:22521609 PMID:23380242 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity
decreases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
epigallocatechin gallate results in decreased activity of CYP1A1 protein
epigallocatechin gallate results in decreased expression of CYP1A1 mRNA
CTD PMID:12970578 PMID:22521609 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775
JBrowse link
G GSTO1 glutathione S-transferase omega 1 multiple interactions
increases expression
EXP [epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of GSTO1 mRNA; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of GSTO1 mRNA] CTD PMID:22521609 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:20580034
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of GSTO1 mRNA]; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of NQO1 mRNA] CTD PMID:22521609 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP epigallocatechin gallate results in increased expression of NQO1 mRNA
[epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of NQO1 mRNA]
CTD PMID:22521609 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Penicillins]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:20580034 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]
epigallocatechin gallate results in decreased expression of VCAM1 mRNA
CTD PMID:22521609 PMID:23380242 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
JBrowse link
(S)-colchicine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMBP alpha-1-microglobulin/bikunin precursor decreases uptake EXP Colchicine results in decreased uptake of AMBP protein CTD PMID:9019736 NCBI chr 1:254,683,885...254,703,220
Ensembl chr 1:254,683,891...254,703,225
JBrowse link
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A3 cytochrome P450 19A3 increases activity EXP o,p'-DDT results in increased activity of CYP19A1 protein CTD PMID:18195494 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G ESR2 estrogen receptor 2 decreases expression EXP o,p'-DDT results in decreased expression of ESR2 protein CTD PMID:18195494 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565
JBrowse link
1,10-phenanthroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANPEP alanyl aminopeptidase, membrane multiple interactions
decreases activity
EXP Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] CTD PMID:17109655 NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881
JBrowse link
G ENPEP glutamyl aminopeptidase multiple interactions EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
1-chloro-2,4-dinitrobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100739508 glutathione S-transferase P-like affects metabolic processing EXP GSTP1 protein affects the metabolism of Dinitrochlorobenzene CTD PMID:14573868 NCBI chr 2:5,005,498...5,009,247 JBrowse link
17beta-estradiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACA acetyl-CoA carboxylase alpha increases phosphorylation EXP Estradiol results in increased phosphorylation of ACACA protein CTD PMID:15967841 NCBI chr12:38,580,916...38,875,067
Ensembl chr12:38,581,457...38,824,712
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions
increases secretion
EXP Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased secretion of Estradiol]; bisphenol A promotes the reaction [ADIPOQ protein results in increased secretion of Estradiol]; Estradiol results in increased expression of and results in increased secretion of ADIPOQ protein; halowax 1051 inhibits the reaction [ADIPOQ protein results in increased secretion of Estradiol]; Hexachlorobenzene inhibits the reaction [ADIPOQ protein results in increased secretion of Estradiol] CTD PMID:28284726 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646
JBrowse link
G ADIPOR1 adiponectin receptor 1 increases expression EXP Estradiol results in increased expression of ADIPOR1 protein CTD PMID:28284726 NCBI chr10:24,907,491...24,923,540
Ensembl chr10:24,907,491...24,915,686
JBrowse link
G ADIPOR2 adiponectin receptor 2 increases expression EXP Estradiol results in increased expression of ADIPOR2 protein CTD PMID:28284726 NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation EXP Estradiol results in increased phosphorylation of AKT1 protein CTD PMID:17348974
G CD40 CD40 molecule affects expression EXP Estradiol affects the expression of CD40 protein CTD PMID:15964915 NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528
JBrowse link
G CD40LG CD40 ligand affects expression EXP Estradiol affects the expression of CD40LG protein CTD PMID:15964915 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,709
JBrowse link
G ESR1 estrogen receptor 1 decreases expression
affects expression
EXP Estradiol results in decreased expression of ESR1 protein; Estradiol results in decreased expression of ESR1 protein alternative form
Estradiol affects the expression of ESR1 protein
CTD PMID:15653758 PMID:16431846 PMID:16680078 PMID:17348974 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 affects expression EXP Estradiol affects the expression of ESR2 protein CTD PMID:15653758 PMID:16680078 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565
JBrowse link
G F3 coagulation factor III, tissue factor affects expression EXP Estradiol affects the expression of F3 mRNA; Estradiol affects the expression of F3 protein CTD PMID:15964915 NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,644...122,837,666
JBrowse link
G FGF7 fibroblast growth factor 7 increases expression EXP Estradiol results in increased expression of FGF7 mRNA CTD PMID:15271478 NCBI chr 1:122,215,878...122,278,705
Ensembl chr 1:122,215,882...122,277,750
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions
increases chemical synthesis
EXP 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [[FSHB protein co-treated with Androstenedione] results in increased chemical synthesis of and results in increased secretion of Estradiol]; [FSHB protein co-treated with Androstenedione] results in increased chemical synthesis of and results in increased secretion of Estradiol; [FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol; bisphenol S inhibits the reaction [[FSHB protein co-treated with Androstenedione] results in increased chemical synthesis of and results in increased secretion of Estradiol]; deoxynivalenol affects the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol]; lead acetate inhibits the reaction [FSHB protein results in increased chemical synthesis of Estradiol] CTD PMID:17656051 PMID:29273543 PMID:34019995 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G HOXA10 homeobox A10 increases expression
multiple interactions
EXP Estradiol results in increased expression of HOXA10 mRNA
Estradiol promotes the reaction [Progesterone results in increased expression of HOXA10 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of HOXA10 mRNA]
CTD PMID:21705055 NCBI chr18:45,393,525...45,403,259
Ensembl chr18:45,393,885...45,403,257
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions
increases abundance
EXP [FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol; deoxynivalenol affects the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol]; deoxynivalenol affects the reaction [IGF1 protein results in increased abundance of Estradiol]; Zearalenone affects the reaction [IGF1 protein results in increased abundance of Estradiol] CTD PMID:17656051 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033
JBrowse link
G LEP leptin increases secretion
increases expression
EXP Estradiol results in increased secretion of LEP protein
Estradiol results in increased expression of LEP mRNA
CTD PMID:23153703 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions
increases secretion
EXP Biological Products inhibits the reaction [LHB protein results in increased secretion of Estradiol]; Cod Liver Oil inhibits the reaction [LHB protein results in increased secretion of Estradiol]; Industrial Waste inhibits the reaction [LHB protein results in increased secretion of Estradiol] CTD PMID:26055946 NCBI chr 6:54,263,574...54,269,286
Ensembl chr 6:54,263,576...54,271,086
JBrowse link
G MMP2 matrix metallopeptidase 2 affects secretion EXP Estradiol affects the secretion of MMP2 protein CTD PMID:15653758 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
affects expression
increases phosphorylation
decreases expression
EXP Estradiol results in increased phosphorylation of and results in increased activity of NOS3 protein; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of NOS3 protein]
Estradiol affects the expression of NOS3 mRNA
Estradiol results in decreased expression of NOS3 mRNA
CTD PMID:15653758 PMID:15967841 PMID:16680078 PMID:17618301 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
G PDGFB platelet derived growth factor subunit B multiple interactions EXP Estradiol affects the secretion of [PDGFB protein binds to PDGFB protein] CTD PMID:15653758 Ensembl chr 5:8,986,462...9,007,435 JBrowse link
G PGR progesterone receptor increases expression EXP Estradiol results in increased expression of PGR mRNA CTD PMID:16431846 NCBI chr 9:32,035,684...32,129,776
Ensembl chr 9:32,035,684...32,129,221
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP Estradiol results in increased phosphorylation of and results in increased activity of PRKAA1 protein CTD PMID:15967841 NCBI chr16:25,745,902...25,783,524
Ensembl chr16:25,745,324...25,783,707
JBrowse link
G PRLR prolactin receptor increases expression EXP Estradiol results in increased expression of PRLR protein alternative form CTD PMID:18492821 NCBI chr16:20,637,568...20,655,881
Ensembl chr16:20,618,875...20,810,140
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Estradiol results in increased expression of PTGS2 mRNA
Fulvestrant inhibits the reaction [Estradiol results in increased expression of PTGS2 mRNA]
CTD PMID:21705055 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
G SPP1 secreted phosphoprotein 1 decreases expression EXP Estradiol results in decreased expression of SPP1 protein CTD PMID:15713688 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b increases expression EXP Estradiol results in increased expression of TNFRSF11B protein CTD PMID:15713688 NCBI chr 4:19,850,212...19,879,132
Ensembl chr 4:19,850,350...19,879,125
JBrowse link
17beta-estradiol 3-benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF7 fibroblast growth factor 7 affects expression EXP estradiol 3-benzoate affects the expression of FGF7 mRNA CTD PMID:15976484 NCBI chr 1:122,215,878...122,278,705
Ensembl chr 1:122,215,882...122,277,750
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 decreases expression
multiple interactions
EXP estradiol 3-benzoate results in decreased expression of FGFR2 mRNA alternative form
[Progesterone co-treated with estradiol 3-benzoate] results in decreased expression of FGFR2 mRNA alternative form
CTD PMID:15976484 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425
JBrowse link
2,2',4,4',5,5'-hexachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 decreases activity EXP 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CYP11A1 protein CTD PMID:16151981 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP19A3 cytochrome P450 19A3 multiple interactions
decreases activity
EXP [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Testosterone] affects the activity of CYP19A1 protein
2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CYP19A1 protein
CTD PMID:16151981 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 multiple interactions
decreases activity
EXP [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Androstenedione] results in increased activity of HSD17B1 protein
2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of HSD17B1 protein
CTD PMID:16151981 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,271,548
JBrowse link
2,2',4,4'-Tetrabromodiphenyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions EXP 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [ADIPOQ protein results in increased secretion of Testosterone]; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:28284726 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646
JBrowse link
G ADIPOR1 adiponectin receptor 1 increases expression EXP 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ADIPOR1 protein CTD PMID:28284726 NCBI chr10:24,907,491...24,923,540
Ensembl chr10:24,907,491...24,915,686
JBrowse link
G ADIPOR2 adiponectin receptor 2 increases expression EXP 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ADIPOR2 protein CTD PMID:28284726 NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
JBrowse link
G COMT catechol-O-methyltransferase increases activity EXP 2,2',4,4'-tetrabromodiphenyl ether results in increased activity of COMT protein CTD PMID:22750137 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998
JBrowse link
G CYP19A3 cytochrome P450 19A3 increases expression
multiple interactions
EXP 2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of CYP19A1 mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP19A1 protein
2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of and results in increased activity of CYP19A1 protein; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]; Fadrozole inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of and results in increased activity of CYP19A1 protein]
CTD PMID:23146758 PMID:28284726 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G ESR1 estrogen receptor 1 increases expression EXP 2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of ESR1 mRNA; 2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of ESR1 protein CTD PMID:24956591 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 increases expression
decreases expression
EXP 2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of ESR2 mRNA; 2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of ESR2 protein
2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ESR2 mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ESR2 protein
CTD PMID:24956591 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 increases expression EXP 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSD17B1 protein CTD PMID:21871953 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,271,548
JBrowse link
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A3 cytochrome P450 19A3 increases activity EXP 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CYP19A1 protein CTD PMID:18195494 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G ESR2 estrogen receptor 2 decreases expression EXP 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in decreased expression of ESR2 protein CTD PMID:18195494 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565
JBrowse link
2,3-dimethoxynaphthalene-1,4-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
G TPO thyroid peroxidase decreases activity EXP 2,3-dimethoxy-1,4-naphthoquinone results in decreased activity of TPO protein CTD PMID:11815678 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208
JBrowse link
2,4-dinitrophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMBP alpha-1-microglobulin/bikunin precursor decreases uptake EXP 2,4-Dinitrophenol results in decreased uptake of AMBP protein CTD PMID:9019736 NCBI chr 1:254,683,885...254,703,220
Ensembl chr 1:254,683,891...254,703,225
JBrowse link
G NOS3 nitric oxide synthase 3 increases expression EXP 2,4-Dinitrophenol results in increased expression of NOS3 mRNA CTD PMID:11382920 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
2,6-di-tert-butyl-4-methylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP Butylated Hydroxytoluene results in increased expression of GCLC mRNA CTD PMID:9535746 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
JBrowse link
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
3',5'-cyclic AMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7B ATPase copper transporting beta multiple interactions EXP Cyclic AMP inhibits the reaction [Copper binds to ATP7B protein] CTD PMID:21084060 NCBI chr11:15,892,549...15,942,070
Ensembl chr11:15,876,612...15,942,064
JBrowse link
G CALCB calcitonin-related polypeptide beta increases abundance EXP CALCA protein results in increased abundance of Cyclic AMP CTD PMID:18463244 NCBI chr 2:44,043,135...44,048,651 JBrowse link
G DUOX2 dual oxidase 2 increases expression EXP Cyclic AMP results in increased expression of DUOX2 mRNA CTD PMID:10601291 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406
JBrowse link
G GCG glucagon affects response to substance
increases abundance
EXP Cyclic AMP affects the susceptibility to GCG protein
GCG protein results in increased abundance of Cyclic AMP
CTD PMID:6253273 NCBI chr15:68,800,557...68,810,268
Ensembl chr15:68,800,560...68,810,242
JBrowse link
G GNRH1 gonadotropin releasing hormone 1 multiple interactions
increases abundance
EXP [Cobalt binds to GNRH1 protein] which results in increased abundance of Cyclic AMP
GNRH1 protein results in increased abundance of Cyclic AMP
CTD PMID:15833593 NCBI chr14:9,442,971...9,447,521
Ensembl chr14:9,442,971...9,453,035
JBrowse link
3',5'-cyclic GMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE5A phosphodiesterase 5A increases degradation EXP PDE5 protein results in increased degradation of Cyclic GMP CTD PMID:18669600 NCBI chr 8:104,270,858...104,420,955
Ensembl chr 8:104,270,881...104,420,953
JBrowse link
G PDE6C phosphodiesterase 6C increases degradation EXP PDE6C protein results in increased degradation of Cyclic GMP CTD PMID:18669600 NCBI chr14:105,010,974...105,122,628
Ensembl chr14:105,050,691...105,122,421
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 increases activity EXP Cyclic GMP results in increased activity of PRKG1 protein CTD PMID:18037907 NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,558,533...98,793,010
JBrowse link
3,3',4,4',5-pentachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor increases expression
multiple interactions
increases activity
EXP 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AHR protein
epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of AHR protein]
CTD PMID:16552988 PMID:22521609 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CAV1 caveolin 1 multiple interactions EXP CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; CAV1 mutant form promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NQO1 mRNA] CTD PMID:19265715 PMID:20406653 PMID:24709675 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 increases expression
multiple interactions
EXP 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein
CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]
CTD PMID:19265715 PMID:22521609 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
JBrowse link
G CTSB cathepsin B decreases expression EXP 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CTSB mRNA CTD PMID:16291828 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,033,877
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 decreases activity EXP 3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CYP11A1 protein CTD PMID:16151981 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP19A3 cytochrome P450 19A3 increases activity
multiple interactions
EXP 3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP19A1 protein
[3,4,5,3',4'-pentachlorobiphenyl co-treated with Testosterone] results in increased activity of CYP19A1 protein
CTD PMID:16151981 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Quercetin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]
3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein
CTD PMID:16291828 PMID:19608276 PMID:22521609 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775
JBrowse link
G GSTO1 glutathione S-transferase omega 1 multiple interactions EXP [epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of GSTO1 mRNA CTD PMID:22521609 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 decreases activity EXP 3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of HSD17B1 protein CTD PMID:16151981 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,271,548
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:20406653 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:20406653 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA] CTD PMID:22521609 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NQO1 mRNA
[epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of NQO1 mRNA; CAV1 mutant form promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NQO1 mRNA]
CTD PMID:22521609 PMID:24709675 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
JBrowse link
G SLC5A5 solute carrier family 5 member 5 decreases expression EXP 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC5A5 mRNA CTD PMID:16291828 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,155...59,885,266
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]
3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein
CTD PMID:20406653 PMID:22521609 PMID:24709675 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
JBrowse link
3,3',4,4'-tetrachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP 3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein; [alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [[alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein] CTD PMID:12970578 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CAV1 caveolin 1 multiple interactions EXP 3,4,3',4'-tetrachlorobiphenyl results in increased expression of and results in increased phosphorylation of CAV1 protein; CAV1 mutant form inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 protein]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of and results in increased phosphorylation of CAV1 protein] CTD PMID:19608276 PMID:20406653 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 increases secretion
increases expression
multiple interactions
EXP 3,4,3',4'-tetrachlorobiphenyl results in increased secretion of CCL2 protein
3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA
[2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; [2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 protein]; [2,2'-azobis(2-amidinopropane) results in increased oxidation of Eicosapentaenoic Acid] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; [2,2'-azobis(2-amidinopropane) results in increased oxidation of Eicosapentaenoic Acid] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 protein]; Acetylcysteine inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; sodium borohydride inhibits the reaction [[2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]]; sulforaphane inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; Tretinoin promotes the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 protein]
CTD PMID:19265715 PMID:21130106 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases activity
increases expression
multiple interactions
EXP 3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein
3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA; 3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 protein
alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 protein]
CTD PMID:12970578 PMID:19608276 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased phosphorylation of MAPK1 protein] CTD PMID:20406653 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased phosphorylation of MAPK3 protein] CTD PMID:20406653 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions
EXP 3,4,3',4'-tetrachlorobiphenyl results in increased activity of RELA protein
[2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of RELA protein]
CTD PMID:21130106 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
JBrowse link
G SELE selectin E increases expression
multiple interactions
EXP 3,4,3',4'-tetrachlorobiphenyl results in increased expression of SELE mRNA
Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of SELE mRNA]
CTD PMID:19608276 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G SELP selectin P multiple interactions
increases expression
EXP Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of SELP mRNA] CTD PMID:19608276 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,399,955
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 mutant form inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 protein]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 mRNA]
3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 mRNA; 3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 protein
CTD PMID:19608276 PMID:20406653 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
JBrowse link
3,3',5,5'-tetrabromobisphenol A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGO2 argonaute RISC catalytic component 2 decreases expression
multiple interactions
EXP tetrabromobisphenol A results in decreased expression of AGO2 protein
[tetrabromobisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in decreased expression of AGO2 protein
CTD PMID:31266599 NCBI chr 4:2,966,794...3,012,388
Ensembl chr 4:2,919,511...3,015,334
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases expression EXP tetrabromobisphenol A results in decreased expression of AKT1 mRNA; tetrabromobisphenol A results in decreased expression of AKT1 protein CTD PMID:35665993
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases activity EXP tetrabromobisphenol A results in decreased activity of ATP2A2 protein CTD PMID:17784851 NCBI chr14:31,674,659...31,744,981
Ensembl chr14:31,674,757...31,744,969
JBrowse link
G ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 decreases activity EXP tetrabromobisphenol A results in decreased activity of ATP2A3 protein CTD PMID:17784851 NCBI chr12:49,980,488...50,014,006
Ensembl chr12:49,980,497...50,025,171
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP tetrabromobisphenol A results in increased expression of BAX mRNA; tetrabromobisphenol A results in increased expression of BAX protein
Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of BAX protein]
CTD PMID:35665993 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP tetrabromobisphenol A results in decreased expression of BCL2 mRNA; tetrabromobisphenol A results in decreased expression of BCL2 protein CTD PMID:35665993 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
EXP tetrabromobisphenol A results in increased expression of CASP3 mRNA; tetrabromobisphenol A results in increased expression of CASP3 protein
Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP3 protein]
CTD PMID:35665993 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CASP8 caspase 8 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in decreased expression of CASP8 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in decreased expression of CASP8 protein]
tetrabromobisphenol A results in decreased expression of CASP8 mRNA; tetrabromobisphenol A results in decreased expression of CASP8 protein
CTD PMID:35665993 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
JBrowse link
G CASP9 caspase 9 multiple interactions
increases expression
EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP9 protein]
tetrabromobisphenol A results in increased expression of CASP9 mRNA; tetrabromobisphenol A results in increased expression of CASP9 protein
CTD PMID:35665993 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
JBrowse link
G COX7A2L cytochrome c oxidase subunit 7A2 like increases expression
multiple interactions
EXP tetrabromobisphenol A results in increased expression of COX7A2L mRNA
Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of COX7A2L mRNA]
CTD PMID:35665993 NCBI chr 3:97,951,115...97,983,309
Ensembl chr 3:97,951,114...97,983,309
JBrowse link
G DICER1 dicer 1, ribonuclease III decreases expression
multiple interactions
EXP tetrabromobisphenol A results in decreased expression of DICER1 mRNA; tetrabromobisphenol A results in decreased expression of DICER1 protein
[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in decreased expression of DICER1 mRNA; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in decreased expression of DICER1 protein
CTD PMID:31266599 NCBI chr 7:116,361,630...116,436,471
Ensembl chr 7:116,365,802...116,411,224
JBrowse link
G DROSHA drosha ribonuclease III increases expression EXP tetrabromobisphenol A results in increased expression of DROSHA mRNA CTD PMID:31266599 NCBI chr16:17,727,695...17,847,954
Ensembl chr16:17,565,137...17,848,162
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 decreases expression
multiple interactions
EXP tetrabromobisphenol A results in decreased expression of GPER1 protein
[tetrabromobisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in decreased expression of GPER1 protein
CTD PMID:31266599 NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,980
JBrowse link
G LOC100623720 collagen alpha-1(VI) chain increases expression
multiple interactions
EXP tetrabromobisphenol A results in increased expression of COL6A1 protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [tetrabromobisphenol A results in increased expression of COL6A1 protein]; tetrabromobisphenol A inhibits the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased expression of COL6A1 protein]
CTD PMID:31266599 NCBI chr13:208,295,245...208,321,789
Ensembl chr13:208,295,451...208,313,127
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions
increases expression
EXP [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in increased expression of MAP1LC3B protein
tetrabromobisphenol A results in increased expression of MAP1LC3B protein
CTD PMID:31266599 NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069
JBrowse link
G MLKL mixed lineage kinase domain like pseudokinase multiple interactions
increases expression
EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of MLKL mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of MLKL protein]
tetrabromobisphenol A results in increased expression of MLKL mRNA; tetrabromobisphenol A results in increased expression of MLKL protein
CTD PMID:35665993 NCBI chr 6:12,923,846...12,951,176
Ensembl chr 6:12,924,894...12,951,173
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma decreases expression EXP tetrabromobisphenol A results in decreased expression of PIK3CG mRNA; tetrabromobisphenol A results in decreased expression of PIK3CG protein CTD PMID:35665993 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
JBrowse link
G PLIN1 perilipin 1 multiple interactions
increases expression
EXP [tetrabromobisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in increased expression of PLIN1 protein
tetrabromobisphenol A results in increased expression of PLIN1 protein
CTD PMID:31266599 NCBI chr 7:55,237,517...55,250,797
Ensembl chr 7:55,236,348...55,250,797
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions
increases expression
EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of PTEN mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of PTEN protein]
tetrabromobisphenol A results in increased expression of PTEN mRNA; tetrabromobisphenol A results in increased expression of PTEN protein
CTD PMID:35665993 NCBI chr14:99,929,590...100,021,619 JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 increases expression
multiple interactions
EXP tetrabromobisphenol A results in increased expression of RIPK1 mRNA; tetrabromobisphenol A results in increased expression of RIPK1 protein
Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK1 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK1 protein]
CTD PMID:35665993 NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,239...1,880,699
JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 multiple interactions
increases expression
EXP Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK3 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK3 protein]
tetrabromobisphenol A results in increased expression of RIPK3 mRNA; tetrabromobisphenol A results in increased expression of RIPK3 protein
CTD PMID:35665993 NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251
JBrowse link
G XPO5 exportin 5 multiple interactions
decreases expression
EXP [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in decreased expression of XPO5 mRNA; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in decreased expression of XPO5 protein
tetrabromobisphenol A results in decreased expression of XPO5 protein
CTD PMID:31266599 NCBI chr 7:38,530,704...38,569,558
Ensembl chr 7:38,531,919...38,569,582
JBrowse link
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5AP arachidonate 5-lipoxygenase activating protein multiple interactions EXP MK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein] CTD PMID:21658425 NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108
JBrowse link
G CASP3 caspase 3 multiple interactions EXP MK-886 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:21658425 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of HIF1A mRNA] CTD PMID:15089098 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA] CTD PMID:15089098 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366
JBrowse link
3-methyladenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA] CTD PMID:28803810 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BECN1 beclin 1 multiple interactions EXP 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein] CTD PMID:28803810 PMID:34811946 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G CASP3 caspase 3 multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:28803810 PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CASP8 caspase 8 multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein] CTD PMID:28803810 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
JBrowse link
G CAT catalase multiple interactions EXP 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein] CTD PMID:34811946 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA] CTD PMID:28803810 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G DCTN4 dynactin subunit 4 multiple interactions EXP 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA] CTD PMID:34811946 NCBI chr 2:151,681,001...151,713,923
Ensembl chr 2:151,681,003...151,783,746
JBrowse link
G FGD4 FYVE, RhoGEF and PH domain containing 4 multiple interactions EXP 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]] CTD PMID:34811946 NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028
JBrowse link
G FIS1 fission, mitochondrial 1 multiple interactions EXP 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]] CTD PMID:34811946 NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA] CTD PMID:34811946 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G LAMP2 lysosomal associated membrane protein 2 decreases expression EXP 3-methyladenine results in decreased expression of LAMP2 protein CTD PMID:36754226 NCBI chr  X:98,586,718...98,623,939
Ensembl chr  X:98,556,710...98,623,940
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions
decreases lipidation
EXP 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; Benzo(a)pyrene promotes the reaction [3-methyladenine results in decreased lipidation of MAP1LC3B protein] CTD PMID:34811946 PMID:36754226 NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069
JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions EXP 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]] CTD PMID:34811946 NCBI chr14:137,266,622...137,296,312 JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions EXP 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]] CTD PMID:34811946 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions EXP 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]] CTD PMID:34811946 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]]; 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein] CTD PMID:30287338 PMID:34811946 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA] CTD PMID:34811946 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions EXP 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein] CTD PMID:28803810 PMID:34811946 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938
JBrowse link
G TOMM20 translocase of outer mitochondrial membrane 20 multiple interactions EXP 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]] CTD PMID:34811946 NCBI chr14:56,113,087...56,127,686
Ensembl chr14:56,113,192...56,127,677
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]] CTD PMID:34811946 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
JBrowse link
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC4A2 solute carrier family 4 member 2 multiple interactions EXP 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid promotes the reaction [SLC4A2 protein binds to SLC4A2 protein] CTD PMID:10387099 NCBI chr18:6,149,459...6,166,622
Ensembl chr18:6,149,459...6,165,212
JBrowse link
4,4'-sulfonyldiphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A3 cytochrome P450 19A3 affects expression
decreases expression
EXP bisphenol S affects the expression of CYP19A1 protein
bisphenol S results in decreased expression of CYP19A1 mRNA
CTD PMID:28352085 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G ESR1 estrogen receptor 1 decreases expression
increases expression
EXP bisphenol S results in decreased expression of ESR1 mRNA
bisphenol S results in increased expression of ESR1 protein
CTD PMID:28352085 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 increases expression
decreases expression
EXP bisphenol S results in increased expression of ESR2 protein
bisphenol S results in decreased expression of ESR2 mRNA
CTD PMID:28352085 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP bisphenol S inhibits the reaction [[FSHB protein co-treated with Androstenedione] results in increased chemical synthesis of and results in increased secretion of Estradiol]; bisphenol S inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone] CTD PMID:34019995 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
4-methylumbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD44 CD44 molecule decreases expression EXP Hymecromone results in decreased expression of CD44 mRNA CTD PMID:23139787 NCBI chr 2:25,788,699...25,884,209
Ensembl chr 2:25,788,703...25,884,153
JBrowse link
G FBN1 fibrillin 1 decreases expression EXP Hymecromone results in decreased expression of FBN1 mRNA CTD PMID:23139787 NCBI chr 1:123,102,011...123,359,649
Ensembl chr 1:123,102,009...123,359,649
JBrowse link
G FN1 fibronectin 1 decreases expression EXP Hymecromone results in decreased expression of FN1 mRNA; Hymecromone results in decreased expression of FN1 protein CTD PMID:23139787 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014
JBrowse link
G TNC tenascin C decreases expression EXP Hymecromone results in decreased expression of TNC mRNA CTD PMID:23139787 NCBI chr 1:255,533,235...255,630,381
Ensembl chr 1:255,533,238...255,630,376
JBrowse link
G VCAN versican decreases expression EXP Hymecromone results in decreased expression of VCAN mRNA; Hymecromone results in decreased expression of VCAN protein CTD PMID:23139787 NCBI chr 2:91,682,177...91,811,674
Ensembl chr 2:91,384,391...91,811,208
JBrowse link
4-nitrocatechol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP 2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol; Skatole inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol] CTD PMID:30599194 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817
JBrowse link
4-nitrophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
increases hydroxylation
EXP 2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; 2-aminoacetophenone inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol; Skatole inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; Skatole inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] CTD PMID:30599194 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817
JBrowse link
4-nonylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 affects phosphorylation EXP 4-nonylphenol affects the phosphorylation of AKT1 protein CTD PMID:38246476
G PDPK1 3-phosphoinositide dependent protein kinase 1 increases phosphorylation EXP 4-nonylphenol results in increased phosphorylation of PDPK1 protein CTD PMID:38246476 NCBI chr 3:39,429,928...39,512,623
Ensembl chr 3:39,432,058...39,512,601
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 increases expression EXP 4-nonylphenol results in increased expression of PIK3R1 protein CTD PMID:38246476 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609
JBrowse link
G PTEN phosphatase and tensin homolog increases expression EXP 4-nonylphenol results in increased expression of PTEN protein CTD PMID:38246476 NCBI chr14:99,929,590...100,021,619 JBrowse link
5-aza-2'-deoxycytidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNMT1 DNA methyltransferase 1 multiple interactions EXP Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein] CTD PMID:29080797 PMID:30923867 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844
JBrowse link
G H2AX H2A.X variant histone multiple interactions EXP Decitabine inhibits the reaction [ochratoxin A results in increased expression of H2AX protein] CTD PMID:30923867 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084
JBrowse link
G JAK2 Janus kinase 2 multiple interactions
decreases phosphorylation
EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of JAK2 protein]
Decitabine results in decreased phosphorylation of JAK2 protein
CTD PMID:30923867 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148
JBrowse link
G NEIL1 nei like DNA glycosylase 1 multiple interactions
increases expression
EXP Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]
Decitabine results in increased expression of NEIL1 mRNA
CTD PMID:30923867 NCBI chr 7:58,261,761...58,269,001
Ensembl chr 7:58,261,769...58,268,522
JBrowse link
G NEIL3 nei like DNA glycosylase 3 multiple interactions
increases expression
EXP Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]
Decitabine results in increased expression of NEIL3 mRNA
CTD PMID:30923867 NCBI chr15:39,416,073...39,632,313
Ensembl chr15:39,581,856...39,632,308
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase increases expression
multiple interactions
EXP Decitabine results in increased expression of OGG1 mRNA
Decitabine inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]
CTD PMID:30923867 NCBI chr13:66,038,669...66,045,478 JBrowse link
G SOCS3 suppressor of cytokine signaling 3 multiple interactions EXP Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 mRNA]; Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 protein] CTD PMID:30923867 NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,009
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of STAT3 protein] CTD PMID:30923867 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992
JBrowse link
5-methyl-pyrazole-3-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAO D-amino acid oxidase decreases activity EXP 5-methylpyrazole-3-carboxylic acid results in decreased activity of DAO protein CTD PMID:20952482 NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633
JBrowse link
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression EXP 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP1A2 mRNA CTD PMID:24176340 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100
JBrowse link
6-anilino-5,8-quinolinedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOD1 superoxide dismutase 1 multiple interactions EXP SOD1 protein affects the susceptibility to [Ditiocarb co-treated with 6-anilino-5,8-quinolinedione] CTD PMID:11861319 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
7,12-dimethyltetraphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP 7-ketocholesterol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein]; [Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein CTD PMID:11042205 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775
JBrowse link
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
acifluorfen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPOX protoporphyrinogen oxidase decreases activity EXP acifluorfen results in decreased activity of PPOX protein CTD PMID:7697001 NCBI chr 4:89,277,984...89,288,946
Ensembl chr 4:89,284,500...89,288,902
JBrowse link
adenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYL9 myosin light chain 9 decreases phosphorylation
multiple interactions
EXP Adenosine results in decreased phosphorylation of MYL9 protein
8-phenyltheophylline inhibits the reaction [Adenosine results in decreased phosphorylation of MYL9 protein]
CTD PMID:10942722 NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293
JBrowse link
ageladine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSNK1A1 casein kinase 1 alpha 1 decreases activity
affects activity
EXP Ageladine A analog results in decreased activity of CSNK1A1 protein
Ageladine A affects the activity of CSNK1A1 protein
CTD PMID:21413800 NCBI chr 2:150,612,845...150,662,431
Ensembl chr 2:150,612,077...150,662,284
JBrowse link
alachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C49 cytochrome P450 2C49 decreases response to substance EXP CYP2C49 protein results in decreased susceptibility to alachlor CTD PMID:16315095 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455
JBrowse link
alpha-mangostin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TP53 tumor protein p53 multiple interactions EXP mangostin inhibits the reaction [Cisplatin results in increased expression of TP53] CTD PMID:20603111 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
JBrowse link
alpha-naphthoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions
increases activity
EXP [alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein; epigallocatechin gallate inhibits the reaction [[alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [alpha-naphthoflavone results in increased activity of AHR protein] CTD PMID:12970578 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA] CTD PMID:19265715 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
decreases activity
EXP alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]
alpha-naphthoflavone results in increased expression of CYP1A1 mRNA
alpha-naphthoflavone results in decreased activity of CYP1A1 protein
CTD PMID:12970578 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775
JBrowse link
alternariol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 decreases expression EXP alternariol results in decreased expression of CYP11A1 protein CTD PMID:19429235 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
ambrisentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 decreases expression EXP ambrisentan results in decreased expression of EDN1 mRNA; ambrisentan results in decreased expression of EDN1 protein CTD PMID:16364719 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G EDNRA endothelin receptor type A decreases expression EXP ambrisentan results in decreased expression of EDNRA mRNA CTD PMID:16364719 NCBI chr 8:81,210,750...81,279,053
Ensembl chr 8:81,209,327...81,276,853
JBrowse link
G IL6 interleukin 6 decreases expression EXP ambrisentan results in decreased expression of IL6 mRNA CTD PMID:16364719 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G LOC110258578 interleukin-1 beta-like decreases expression EXP ambrisentan results in decreased expression of IL1B mRNA CTD PMID:16364719
G NOS3 nitric oxide synthase 3 decreases expression EXP ambrisentan results in decreased expression of NOS3 mRNA CTD PMID:16364719 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
G TNF tumor necrosis factor decreases expression EXP ambrisentan results in decreased expression of TNF mRNA CTD PMID:16364719 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator increases activity EXP Amiloride results in increased activity of CFTR protein CTD PMID:15246976 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950
JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions EXP Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein] CTD PMID:9853007 NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172
JBrowse link
G PLG plasminogen multiple interactions EXP Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Serpentine results in increased cleavage of PLG protein] CTD PMID:9853007 NCBI chr 1:7,062,399...7,109,521
Ensembl chr 1:7,061,192...7,110,555
JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions EXP Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA] CTD PMID:12081571 NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,535,440...168,560,867
JBrowse link
aminoglutethimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GHRL ghrelin and obestatin prepropeptide multiple interactions EXP Aminoglutethimide promotes the reaction [GHRL protein results in decreased secretion of Progesterone] CTD PMID:22341706 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,445,992...66,452,917
JBrowse link
antimycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMBP alpha-1-microglobulin/bikunin precursor decreases uptake EXP Antimycin A results in decreased uptake of AMBP protein CTD PMID:9019736 NCBI chr 1:254,683,885...254,703,220
Ensembl chr 1:254,683,891...254,703,225
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP [Antimycin A co-treated with Deoxyglucose] results in increased expression of BAX protein; Quercetin inhibits the reaction [[Antimycin A co-treated with Deoxyglucose] results in increased expression of BAX protein] CTD PMID:25087994 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions EXP [Antimycin A co-treated with Deoxyglucose] results in decreased phosphorylation of MTOR protein; Quercetin promotes the reaction [[Antimycin A co-treated with Deoxyglucose] results in decreased phosphorylation of MTOR protein] CTD PMID:25087994 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
JBrowse link
apigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] CTD PMID:26180592 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:26180592 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:26180592 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
aristolochic acid A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5AP arachidonate 5-lipoxygenase activating protein increases expression
multiple interactions
EXP aristolochic acid I results in increased expression of ALOX5AP protein
MK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein]; U 0126 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein]
CTD PMID:21658425 NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108
JBrowse link
G CASP3 caspase 3 multiple interactions EXP aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein; MK-886 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:21658425 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G LTC4S leukotriene C4 synthase decreases expression EXP aristolochic acid I results in decreased expression of LTC4S protein CTD PMID:21658425 NCBI chr 2:78,799,446...78,802,281
Ensembl chr 2:78,799,449...78,802,285
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP aristolochic acid I results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [aristolochic acid I results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:21658425 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP aristolochic acid I results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [aristolochic acid I results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:21658425 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MGST3 microsomal glutathione S-transferase 3 increases expression
multiple interactions
EXP aristolochic acid I results in increased expression of MGST3 protein
U 0126 inhibits the reaction [aristolochic acid I results in increased expression of MGST3 protein]
CTD PMID:21658425 NCBI chr 4:85,069,603...85,095,022
Ensembl chr 4:85,069,607...85,094,981
JBrowse link
arotinoid acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FABP4 fatty acid binding protein 4 decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of FABP4 mRNA CTD PMID:15583048 NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,896
JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 decreases activity EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased activity of GPD1 protein CTD PMID:15583048 NCBI chr 5:16,008,179...16,021,676
Ensembl chr 5:16,007,448...16,017,825
JBrowse link
G NR2F1 nuclear receptor subfamily 2 group F member 1 increases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of NR2F1 mRNA CTD PMID:15583048 NCBI chr 2:100,447,661...100,457,510
Ensembl chr 2:100,447,705...100,457,506
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of PPARG mRNA CTD PMID:15583048 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
JBrowse link
G RXRA retinoid X receptor alpha decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of RXRA mRNA CTD PMID:15583048 NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,505...273,797,620
JBrowse link
G SREBP-1 sterol regulatory element binding protein 1 decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of SREBP-1 mRNA CTD PMID:15583048
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions
increases hydrolysis
EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
ATP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions
EXP Adenosine Triphosphate results in increased expression of BCL2 protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of BCL2 protein]
CTD PMID:17997382 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G CASP8 caspase 8 increases activity
multiple interactions
EXP Adenosine Triphosphate results in increased activity of CASP8 protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased activity of CASP8 protein]
CTD PMID:17997382 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
JBrowse link
G CYCS cytochrome c, somatic affects localization
multiple interactions
EXP Adenosine Triphosphate affects the localization of CYCS protein
[Calcium co-treated with Phosphates co-treated with Adenosine Triphosphate] affects the localization of CYCS protein; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate affects the localization of CYCS protein]
CTD PMID:16489745 PMID:17997382 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G MYL9 myosin light chain 9 decreases phosphorylation
multiple interactions
EXP Adenosine Triphosphate results in decreased phosphorylation of MYL9 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]]; Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]
CTD PMID:10942722 NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293
JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions
EXP Adenosine Triphosphate results in increased expression of TNF protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of TNF protein]
CTD PMID:17997382 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
benzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC9A1 solute carrier family 9 member A1 decreases activity EXP benzamide analog results in decreased activity of SLC9A1 protein CTD PMID:17724433 NCBI chr 6:84,373,921...84,426,447
Ensembl chr 6:84,372,649...84,426,997
JBrowse link
benzamidoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MOCOS molybdenum cofactor sulfurase affects reduction EXP MOCOS protein affects the reduction of benzamidoxime CTD PMID:16973608 NCBI chr 6:119,945,076...120,018,332
Ensembl chr 6:119,945,052...120,018,097
JBrowse link
benzo[a]pyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions EXP Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]; Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased secretion of Estradiol]; Benzo(a)pyrene results in decreased expression of and results in decreased secretion of ADIPOQ protein CTD PMID:28284726 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646
JBrowse link
G ADIPOR1 adiponectin receptor 1 decreases expression EXP Benzo(a)pyrene results in decreased expression of ADIPOR1 protein CTD PMID:28284726 NCBI chr10:24,907,491...24,923,540
Ensembl chr10:24,907,491...24,915,686
JBrowse link
G ADIPOR2 adiponectin receptor 2 decreases expression EXP Benzo(a)pyrene results in decreased expression of ADIPOR2 protein CTD PMID:28284726 NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions
increases expression
EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of ATF4 protein] CTD PMID:36754226 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
JBrowse link
G ATF6 activating transcription factor 6 multiple interactions
increases expression
EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of ATF6 protein] CTD PMID:36754226 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Benzo(a)pyrene results in increased expression of BAX protein CTD PMID:36754226 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Benzo(a)pyrene results in decreased expression of BCL2 protein CTD PMID:36754226 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression
multiple interactions
EXP Benzo(a)pyrene results in decreased expression of BCL2L1 protein
4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of BCL2L1 protein]; Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2L1 protein]
CTD PMID:36754226 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694
JBrowse link
G CCNB1 cyclin B1 decreases expression EXP Benzo(a)pyrene results in decreased expression of CCNB1 protein CTD PMID:36754226 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377
JBrowse link
G CLDN1 claudin 1 decreases expression
multiple interactions
EXP Benzo(a)pyrene results in decreased expression of CLDN1 protein
4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of CLDN1 protein]; Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of CLDN1 protein]
CTD PMID:36754226 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
JBrowse link
G CLDN3 claudin 3 decreases expression
multiple interactions
EXP Benzo(a)pyrene results in decreased expression of CLDN3 protein
4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of CLDN3 protein]
CTD PMID:36754226 NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102
JBrowse link
G CYP19A3 cytochrome P450 19A3 multiple interactions EXP Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein] CTD PMID:28284726 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
multiple interactions
EXP Benzo(a)pyrene results in increased expression of CYP1A1 protein
7-ketocholesterol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein]; [Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein
CTD PMID:11042205 PMID:18636242 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression
multiple interactions
EXP Benzo(a)pyrene results in increased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of DDIT3 protein]
CTD PMID:36754226 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Benzo(a)pyrene results in increased phosphorylation of EIF2S1 protein CTD PMID:36754226 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 increases phosphorylation
multiple interactions
EXP Benzo(a)pyrene results in increased phosphorylation of ERN1 protein
4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of ERN1 protein]
CTD PMID:36754226 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284
JBrowse link
G H2AX H2A.X variant histone increases expression EXP Benzo(a)pyrene results in increased expression of H2AX protein CTD PMID:36754226 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of HSPA5 protein] CTD PMID:36754226 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
G LAMP2 lysosomal associated membrane protein 2 multiple interactions
decreases expression
EXP bafilomycin A1 inhibits the reaction [Benzo(a)pyrene results in decreased expression of LAMP2 protein]; Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of LAMP2 protein] CTD PMID:36754226 NCBI chr  X:98,586,718...98,623,939
Ensembl chr  X:98,556,710...98,623,940
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta decreases lipidation
multiple interactions
EXP Benzo(a)pyrene results in decreased lipidation of MAP1LC3B protein
bafilomycin A1 inhibits the reaction [Benzo(a)pyrene results in decreased lipidation of MAP1LC3B protein]; Benzo(a)pyrene promotes the reaction [3-methyladenine results in decreased lipidation of MAP1LC3B protein]; Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased lipidation of MAP1LC3B protein]
CTD PMID:36754226 NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 decreases expression EXP Benzo(a)pyrene results in decreased expression of NFE2L2 protein CTD PMID:36754226 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
G OCLN occludin decreases expression
multiple interactions
EXP Benzo(a)pyrene results in decreased expression of OCLN protein
4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of OCLN protein]
CTD PMID:36754226 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP Benzo(a)pyrene results in decreased expression of PCNA protein CTD PMID:36754226 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744
JBrowse link
G TJP1 tight junction protein 1 decreases expression
multiple interactions
EXP Benzo(a)pyrene results in decreased expression of TJP1 protein
4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of TJP1 protein]
CTD PMID:36754226 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836
JBrowse link
G TJP2 tight junction protein 2 decreases expression EXP Benzo(a)pyrene results in decreased expression of TJP2 protein CTD PMID:36754226 NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983
JBrowse link
beta-naphthoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
increases activity
multiple interactions
EXP beta-Naphthoflavone results in increased expression of CYP1A1 mRNA; beta-Naphthoflavone results in increased expression of CYP1A1 protein
beta-Naphthoflavone results in increased activity of CYP1A1 protein
epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
CTD PMID:12970578 PMID:19464568 PMID:19786062 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression EXP beta-Naphthoflavone results in increased expression of CYP1A2 mRNA CTD PMID:19464568 PMID:24176340 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases expression EXP beta-Naphthoflavone results in increased expression of CYP1B1 mRNA CTD PMID:19464568 PMID:19786062 NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,205,683
JBrowse link
bezafibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 increases expression
increases secretion
EXP Bezafibrate results in increased expression of APOA1 mRNA
Bezafibrate results in increased secretion of APOA1 protein
CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of BAX protein] CTD PMID:16316343 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression EXP Bezafibrate results in increased expression of BCL2 CTD PMID:16316343 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G CASP3 caspase 3 multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:16316343 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of CYCS protein] CTD PMID:16316343 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G LIPG lipase G, endothelial type decreases expression EXP Bezafibrate results in decreased expression of LIPG mRNA; Bezafibrate results in decreased expression of LIPG protein CTD PMID:15953354 NCBI chr 1:99,081,940...99,110,671
Ensembl chr 1:99,081,938...99,110,874
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP Bezafibrate inhibits the reaction [[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified]; Bezafibrate inhibits the reaction [Cisplatin results in decreased activity of PPARA protein] CTD PMID:16316343 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239
JBrowse link
G SCARB1 scavenger receptor class B member 1 affects localization
increases expression
EXP Bezafibrate affects the localization of SCARB1 protein
Bezafibrate results in increased expression of SCARB1 mRNA
CTD PMID:16530456 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,568
JBrowse link
bilirubin IXalpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Bilirubin inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of CASP3 protein] CTD PMID:16371440 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
bisphenol A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 increases expression EXP bisphenol A results in increased expression of ADCYAP1 protein CTD PMID:29569701 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions EXP bisphenol A inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]; bisphenol A inhibits the reaction [ADIPOQ protein results in increased secretion of Testosterone]; bisphenol A promotes the reaction [ADIPOQ protein results in increased secretion of Estradiol]; bisphenol A results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:28284726 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646
JBrowse link
G ADIPOR1 adiponectin receptor 1 increases expression EXP bisphenol A results in increased expression of ADIPOR1 protein CTD PMID:28284726 NCBI chr10:24,907,491...24,923,540
Ensembl chr10:24,907,491...24,915,686
JBrowse link
G ADIPOR2 adiponectin receptor 2 increases expression EXP bisphenol A results in increased expression of ADIPOR2 protein CTD PMID:28284726 NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
JBrowse link
G AGO2 argonaute RISC catalytic component 2 decreases expression
multiple interactions
EXP bisphenol A results in decreased expression of AGO2 protein
[bisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in decreased expression of AGO2 protein
CTD PMID:31266599 NCBI chr 4:2,966,794...3,012,388
Ensembl chr 4:2,919,511...3,015,334
JBrowse link
G ALB albumin multiple interactions
decreases expression
EXP Cysteine inhibits the reaction [bisphenol A results in decreased expression of ALB protein] CTD PMID:37999554 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696
JBrowse link
G AQP3 aquaporin 3 decreases expression EXP bisphenol A results in decreased expression of AQP3 mRNA CTD PMID:32710935 NCBI chr10:33,045,374...33,050,285
Ensembl chr10:33,045,245...33,051,082
JBrowse link
G AQP4 aquaporin 4 decreases expression EXP bisphenol A results in decreased expression of AQP4 mRNA CTD PMID:32710935 NCBI chr 6:111,407,632...111,422,169
Ensembl chr 6:111,407,639...111,422,109
JBrowse link
G AQP9 aquaporin 9 affects expression EXP bisphenol A affects the expression of AQP9 mRNA CTD PMID:32710935 NCBI chr 1:113,798,380...113,848,452
Ensembl chr 1:113,794,040...113,848,683
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions
increases expression
EXP Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of ATF4 protein] CTD PMID:37108405 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
JBrowse link
G ATF6 activating transcription factor 6 increases expression
multiple interactions
EXP bisphenol A results in increased expression of ATF6 protein
Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of ATF6 protein]
CTD PMID:37108405 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP bisphenol A results in increased expression of BAX mRNA; bisphenol A results in increased expression of BAX protein
Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of BAX protein]
CTD PMID:37108405 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP bisphenol A results in decreased expression of BCL2 mRNA; bisphenol A results in decreased expression of BCL2 protein
Sodium Selenite inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Sodium Selenite inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]
CTD PMID:28819136 PMID:37108405 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression
multiple interactions
EXP bisphenol A results in decreased expression of BCL2L1 mRNA; bisphenol A results in decreased expression of BCL2L1 protein
Sodium Selenite affects the reaction [bisphenol A results in decreased expression of BCL2L1 protein]
CTD PMID:28819136 PMID:37108405 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694
JBrowse link
G BECN1 beclin 1 increases expression EXP bisphenol A results in increased expression of BECN1 mRNA CTD PMID:28819136 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G CARTPT CART prepropeptide increases expression
decreases expression
EXP bisphenol A results in increased expression of CARTPT protein
bisphenol A results in decreased expression of CARTPT protein
CTD PMID:29558425 PMID:29569701 PMID:29577965 PMID:29888781 PMID:38069115 NCBI chr16:48,043,558...48,045,592
Ensembl chr16:48,043,492...48,045,592
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
EXP [bisphenol A co-treated with fisetin] results in increased expression of CASP3 mRNA; Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]
bisphenol A results in increased expression of CASP3 mRNA; bisphenol A results in increased expression of CASP3 protein
CTD PMID:29544186 PMID:37108405 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CASP8 caspase 8 multiple interactions
increases expression
EXP Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of CASP8 mRNA] CTD PMID:37108405 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
JBrowse link
G CASP9 caspase 9 multiple interactions
increases expression
EXP Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of CASP9 mRNA] CTD PMID:37108405 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
JBrowse link
G CAT catalase multiple interactions
decreases activity
decreases expression
EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; Sodium Selenite inhibits the reaction [bisphenol A results in decreased activity of CAT protein] CTD PMID:29129240 PMID:37108405 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP bisphenol A results in increased expression of CDKN1A protein CTD PMID:28819136 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761
JBrowse link
G CLDN1 claudin 1 decreases expression
multiple interactions
EXP bisphenol A results in decreased expression of CLDN1 mRNA; bisphenol A results in decreased expression of CLDN1 protein
Cysteine inhibits the reaction [bisphenol A results in decreased expression of CLDN1 mRNA]; Sodium Selenite inhibits the reaction [bisphenol A results in decreased expression of CLDN1 protein]
CTD PMID:37108405 PMID:37999554 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 multiple interactions
decreases expression
EXP [bisphenol A co-treated with fisetin] results in decreased expression of CYP11A1 mRNA; fisetin promotes the reaction [bisphenol A results in decreased expression of CYP11A1 mRNA] CTD PMID:29544186 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP19A3 cytochrome P450 19A3 increases expression
multiple interactions
EXP bisphenol A results in increased expression of CYP19A1 protein
bisphenol A inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]
CTD PMID:28284726 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G DBH dopamine beta-hydroxylase increases expression EXP bisphenol A results in increased expression of DBH protein CTD PMID:29888781 NCBI chr 1:273,204,407...273,225,562
Ensembl chr 1:273,204,175...273,225,552
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression
multiple interactions
EXP bisphenol A results in increased expression of DDIT3 protein
Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of DDIT3 protein]
CTD PMID:37108405 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
JBrowse link
G DICER1 dicer 1, ribonuclease III decreases expression
multiple interactions
EXP bisphenol A results in decreased expression of DICER1 mRNA; bisphenol A results in decreased expression of DICER1 protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in decreased expression of DICER1 protein]; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with bisphenol A] results in decreased expression of DICER1 mRNA
CTD PMID:31266599 NCBI chr 7:116,361,630...116,436,471
Ensembl chr 7:116,365,802...116,411,224
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions
decreases expression
EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA] CTD PMID:28445388 PMID:28819136 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087
JBrowse link
G DNMT3B DNA methyltransferase 3 beta decreases expression EXP bisphenol A results in decreased expression of DNMT3B mRNA CTD PMID:28819136 NCBI chr17:36,345,715...36,386,076
Ensembl chr17:36,345,816...36,386,072
JBrowse link
G DROSHA drosha ribonuclease III multiple interactions
decreases expression
EXP 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in decreased expression of DROSHA protein]; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with bisphenol A] results in increased expression of DROSHA mRNA; bisphenol A inhibits the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased expression of DROSHA protein] CTD PMID:31266599 NCBI chr16:17,727,695...17,847,954
Ensembl chr16:17,565,137...17,848,162
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
EXP Sodium Selenite inhibits the reaction [bisphenol A results in increased phosphorylation of EIF2AK3 protein] CTD PMID:37108405 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 increases expression
multiple interactions
EXP bisphenol A results in increased expression of ERN1 protein
Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of ERN1 protein]
CTD PMID:37108405 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP bisphenol A inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; bisphenol A promotes the reaction [fisetin inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]]; fisetin promotes the reaction [bisphenol A inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]] CTD PMID:29544186 PMID:34019995 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G GAL galanin and GMAP prepropeptide increases expression
affects expression
EXP bisphenol A results in increased expression of GAL protein
bisphenol A affects the expression of GAL protein
CTD PMID:29558425 PMID:29569701 PMID:29577965 PMID:29888781 PMID:38069115 NCBI chr 2:4,351,113...4,357,167
Ensembl chr 2:4,351,113...4,356,647
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions
increases expression
EXP Cysteine inhibits the reaction [bisphenol A results in increased expression of GCLC mRNA] CTD PMID:37999554 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression
multiple interactions
EXP bisphenol A results in increased expression of GCLM mRNA
Cysteine inhibits the reaction [bisphenol A results in increased expression of GCLM mRNA]
CTD PMID:37999554 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 multiple interactions EXP [bisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in decreased expression of GPER1 protein CTD PMID:31266599 NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,980
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
decreases expression
EXP [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA
bisphenol A results in decreased expression of GPX1 mRNA
CTD PMID:28819136 PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G GYS1 glycogen synthase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter CTD PMID:29065941 NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261
JBrowse link
G HMOX1 heme oxygenase 1 decreases expression
multiple interactions
EXP bisphenol A results in decreased expression of HMOX1 mRNA
Cysteine inhibits the reaction [bisphenol A results in decreased expression of HMOX1 mRNA]
CTD PMID:37999554
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions
decreases expression
EXP bisphenol A promotes the reaction [fisetin results in decreased expression of HSD3B1 mRNA]; fisetin promotes the reaction [bisphenol A results in decreased expression of HSD3B1 mRNA] CTD PMID:29544186 NCBI chr 4:101,565,229...101,574,110 JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
EXP bisphenol A results in increased expression of HSPA5 protein
Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of HSPA5 protein]
CTD PMID:37108405 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
G IFNG interferon gamma increases expression
multiple interactions
EXP bisphenol A results in increased expression of IFNG mRNA
Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of IFNG mRNA]
CTD PMID:37108405 PMID:38154151 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670
JBrowse link
G IGF1 insulin like growth factor 1 decreases expression EXP bisphenol A results in decreased expression of IGF1 mRNA CTD PMID:32710935 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033
JBrowse link
G IGF1R insulin like growth factor 1 receptor decreases expression EXP bisphenol A results in decreased expression of IGF1R mRNA CTD PMID:32710935 NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058
JBrowse link
G IL10 interleukin 10 multiple interactions
decreases expression
decreases secretion
EXP Glutamine inhibits the reaction [bisphenol A results in decreased secretion of IL10 protein]; Sodium Selenite inhibits the reaction [bisphenol A results in decreased expression of IL10 mRNA] CTD PMID:37108405 PMID:38154151 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378
JBrowse link
G IL17A interleukin 17A increases expression
multiple interactions
EXP bisphenol A results in increased expression of IL17A mRNA
Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of IL17A mRNA]
CTD PMID:37108405 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153
JBrowse link
G IL6 interleukin 6 multiple interactions
increases secretion
increases expression
EXP Glutamine inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Glutamine inhibits the reaction [bisphenol A results in increased secretion of IL6 protein]; Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA] CTD PMID:37108405 PMID:38154151 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G KEAP1 kelch like ECH associated protein 1 increases expression
multiple interactions
EXP bisphenol A results in increased expression of KEAP1 mRNA
Cysteine inhibits the reaction [bisphenol A results in increased expression of KEAP1 mRNA]
CTD PMID:37999554 NCBI chr 2:69,280,940...69,290,267
Ensembl chr 2:69,276,336...69,294,382
JBrowse link
G LDHA lactate dehydrogenase A increases expression
multiple interactions
decreases methylation
EXP bisphenol A results in increased expression of LDHA mRNA
[bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter
bisphenol A results in decreased methylation of LDHA promoter
CTD PMID:29065941 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715
JBrowse link
G LOC100623720 collagen alpha-1(VI) chain multiple interactions
decreases expression
EXP bisphenol A inhibits the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased expression of COL6A1 protein]
bisphenol A results in decreased expression of COL6A1 protein
CTD PMID:31266599 NCBI chr13:208,295,245...208,321,789
Ensembl chr13:208,295,451...208,313,127
JBrowse link
G LOC110258578 interleukin-1 beta-like increases expression
multiple interactions
increases secretion
EXP bisphenol A results in increased expression of IL1B mRNA; bisphenol A results in increased expression of IL1B protein
Glutamine inhibits the reaction [bisphenol A results in increased secretion of IL1B protein]; Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of IL1B mRNA]
CTD PMID:29558425 PMID:37108405 PMID:38154151
G MAP1LC3B microtubule associated protein 1 light chain 3 beta increases expression EXP bisphenol A results in increased expression of MAP1LC3B protein CTD PMID:31266599 NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069
JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 affects expression EXP bisphenol A affects the expression of MAP3K7 protein CTD PMID:29577965 NCBI chr 1:58,482,046...58,548,087
Ensembl chr 1:58,481,956...58,548,057
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor increases expression
multiple interactions
EXP bisphenol A results in increased expression of MYD88 mRNA
Glutamine inhibits the reaction [bisphenol A results in increased expression of MYD88 mRNA]
CTD PMID:38154151 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109
JBrowse link
G NANOG Nanog homeobox decreases expression EXP bisphenol A results in decreased expression of NANOG mRNA CTD PMID:28819136 NCBI chr 5:62,931,642...62,939,086
Ensembl chr 5:62,932,382...62,939,082
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
EXP bisphenol A results in increased expression of NFKB1 mRNA
Glutamine inhibits the reaction [bisphenol A results in increased expression of NFKB1 mRNA]
CTD PMID:38154151 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691
JBrowse link
G NOS1 nitric oxide synthase 1 increases expression EXP bisphenol A results in increased expression of NOS1 protein CTD PMID:38069115 NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,944
JBrowse link
G NOX1 NADPH oxidase 1 decreases expression
multiple interactions
EXP bisphenol A results in decreased expression of NOX1 mRNA
Cysteine inhibits the reaction [bisphenol A results in decreased expression of NOX1 mRNA]
CTD PMID:37999554 NCBI chr  X:82,540,664...82,575,811
Ensembl chr  X:82,540,667...82,586,532
JBrowse link
G OCLN occludin decreases expression
multiple interactions
EXP bisphenol A results in decreased expression of OCLN protein
Sodium Selenite affects the reaction [bisphenol A results in decreased expression of OCLN protein]
CTD PMID:37108405 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033
JBrowse link
G PLIN1 perilipin 1 increases expression
multiple interactions
EXP bisphenol A results in increased expression of PLIN1 protein
[bisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in increased expression of PLIN1 protein
CTD PMID:31266599 NCBI chr 7:55,237,517...55,250,797
Ensembl chr 7:55,236,348...55,250,797
JBrowse link
G POU5F1 POU class 5 homeobox 1 decreases expression EXP bisphenol A results in decreased expression of POU5F1 mRNA; bisphenol A results in decreased expression of POU5F1 protein CTD PMID:28819136 NCBI chr 7:23,564,654...23,570,691 JBrowse link
G PPP1R16A protein phosphatase 1 regulatory subunit 16A increases activity
multiple interactions
EXP bisphenol A results in increased activity of GPT protein
Cysteine inhibits the reaction [bisphenol A results in increased activity of GPT protein]
CTD PMID:37999554 NCBI chr 4:302,621...320,048
Ensembl chr 4:297,748...320,056
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases expression
multiple interactions
EXP bisphenol A results in increased expression of RELA protein
Glutamine inhibits the reaction [bisphenol A results in increased expression of RELA protein]
CTD PMID:38154151 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
JBrowse link
G SDHA succinate dehydrogenase complex flavoprotein subunit A decreases expression
multiple interactions
EXP bisphenol A results in decreased expression of SDHA mRNA
Cysteine inhibits the reaction [bisphenol A results in decreased expression of SDHA mRNA]
CTD PMID:37999554 NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524
JBrowse link
G SI sucrase-isomaltase decreases expression EXP bisphenol A results in decreased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 decreases expression
decreases methylation
multiple interactions
EXP bisphenol A results in decreased expression of SLC15A1 mRNA
bisphenol A results in decreased methylation of SLC15A1 promoter
[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]
CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC18A3 solute carrier family 18 member A3 decreases expression EXP bisphenol A results in decreased expression of SLC18A3 protein CTD PMID:29558425 PMID:29577965 NCBI chr14:90,113,534...90,115,813
Ensembl chr14:90,113,844...90,115,430
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841
JBrowse link
G SLC7A1 solute carrier family 7 member 1 increases expression EXP bisphenol A results in increased expression of SLC7A1 mRNA CTD PMID:32710935 NCBI chr11:6,538,053...6,604,654
Ensembl chr11:6,538,045...6,604,658
JBrowse link
G SLC7A7 solute carrier family 7 member 7 decreases expression EXP bisphenol A results in decreased expression of SLC7A7 mRNA CTD PMID:32710935 NCBI chr 7:76,195,774...76,235,406
Ensembl chr 7:76,198,256...76,235,402
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression EXP bisphenol A results in decreased expression of SOD1 mRNA CTD PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
G SOD2 superoxide dismutase 2 decreases expression
multiple interactions
EXP bisphenol A results in decreased expression of SOD2 mRNA
Cysteine inhibits the reaction [bisphenol A results in decreased expression of SOD2 mRNA]
CTD PMID:37999554 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G SOX2 SRY-box transcription factor 2 decreases expression EXP bisphenol A results in decreased expression of SOX2 mRNA CTD PMID:28819136 NCBI chr13:119,668,476...119,669,435
Ensembl chr13:119,668,476...119,669,435
JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions
decreases expression
EXP [bisphenol A co-treated with fisetin] results in decreased expression of STAR mRNA; fisetin promotes the reaction [bisphenol A results in decreased expression of STAR mRNA] CTD PMID:29544186 NCBI chr15:48,377,597...48,385,398
Ensembl chr15:48,377,521...48,385,462
JBrowse link
G TAC1 tachykinin precursor 1 increases expression EXP bisphenol A results in increased expression of TAC1 protein CTD PMID:29558425 PMID:29569701 PMID:29888781 PMID:38069115 NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,536...77,206,523
JBrowse link
G TFAM transcription factor A, mitochondrial decreases expression EXP bisphenol A results in decreased expression of TFAM mRNA CTD PMID:28819136 NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,731
JBrowse link
G TFF3 trefoil factor 3 multiple interactions
decreases expression
EXP Glutamine inhibits the reaction [bisphenol A results in decreased expression of TFF3 protein] CTD PMID:38154151 NCBI chr13:205,641,038...205,644,333
Ensembl chr13:205,641,038...205,644,333
JBrowse link
G TJP1 tight junction protein 1 multiple interactions
decreases expression
EXP Sodium Selenite affects the reaction [bisphenol A results in decreased expression of TJP1 protein] CTD PMID:37108405 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836
JBrowse link
G TJP2 tight junction protein 2 multiple interactions
decreases expression
EXP Cysteine inhibits the reaction [bisphenol A results in decreased expression of TJP2 mRNA] CTD PMID:37999554 NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983
JBrowse link
G TLR4 toll like receptor 4 multiple interactions
increases expression
EXP Glutamine inhibits the reaction [bisphenol A results in increased expression of TLR4 mRNA]; Glutamine inhibits the reaction [bisphenol A results in increased expression of TLR4 protein]
bisphenol A results in increased expression of TLR4 mRNA; bisphenol A results in increased expression of TLR4 protein
CTD PMID:38154151 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970
JBrowse link
G TNF tumor necrosis factor increases expression
increases secretion
multiple interactions
EXP bisphenol A results in increased expression of TNF mRNA; bisphenol A results in increased expression of TNF protein
bisphenol A results in increased secretion of TNF protein
Glutamine inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Glutamine inhibits the reaction [bisphenol A results in increased secretion of TNF protein]; Sodium Selenite inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]
CTD PMID:29558425 PMID:37108405 PMID:38154151 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
G TP53 tumor protein p53 increases expression EXP bisphenol A results in increased expression of TP53 protein CTD PMID:28819136 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
JBrowse link
G VEGFA vascular endothelial growth factor A increases expression EXP bisphenol A results in increased expression of VEGFA protein CTD PMID:20172683 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366
JBrowse link
G VIP vasoactive intestinal peptide decreases expression
increases expression
EXP bisphenol A results in decreased expression of VIP protein
bisphenol A results in increased expression of VIP protein
CTD PMID:29558425 PMID:29577965 NCBI chr 1:13,611,786...13,620,250
Ensembl chr 1:13,611,311...13,620,269
JBrowse link
G XPO5 exportin 5 multiple interactions
decreases expression
EXP [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with bisphenol A] results in decreased expression of XPO5 mRNA; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with bisphenol A] results in decreased expression of XPO5 protein
bisphenol A results in decreased expression of XPO5 mRNA; bisphenol A results in decreased expression of XPO5 protein
CTD PMID:31266599 NCBI chr 7:38,530,704...38,569,558
Ensembl chr 7:38,531,919...38,569,582
JBrowse link
Bisphenol A diglycidyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPL alkaline phosphatase, biomineralization associated multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA] CTD PMID:30481989 NCBI chr 6:79,589,695...79,649,646
Ensembl chr 6:79,589,045...79,649,644
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL1A1 mRNA] CTD PMID:30481989 NCBI chr12:26,379,087...26,397,180
Ensembl chr12:26,379,090...26,397,004
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CTNNB1 mRNA] CTD PMID:30481989 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311
JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of FABP4 mRNA] CTD PMID:30481989 NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,896
JBrowse link
G IL6 interleukin 6 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Rosiglitazone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Rosiglitazone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]] CTD PMID:19474210 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane binds to and results in decreased activity of PPARG protein; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of PPARG mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Troglitazone results in increased activity of PPARG protein] CTD PMID:14506076 PMID:14519784 PMID:30481989 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of RUNX2 mRNA] CTD PMID:30481989 NCBI chr 7:40,106,581...40,353,304
Ensembl chr 7:40,106,532...40,460,687
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA] CTD PMID:30481989 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Rosiglitazone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Rosiglitazone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased expression of TNF mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased expression of TNF protein] CTD PMID:17217567 PMID:19474210 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
bisphenol F term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP 4,4'-bisphenol F inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone] CTD PMID:34019995 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression EXP 4,4'-bisphenol F results in increased expression of MMP9 mRNA CTD PMID:34019995 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788
JBrowse link
brimonidine tartrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
EXP Brimonidine Tartrate results in increased phosphorylation of CREB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]
CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728
JBrowse link
bucladesine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP Bucladesine results in increased expression of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,508...104,384,547
JBrowse link
caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATM protein] CTD PMID:38104654 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,658...36,759,552
JBrowse link
G CCNB1 cyclin B1 multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in decreased expression of CCNB1 protein] CTD PMID:38104654 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377
JBrowse link
G CDC25C cell division cycle 25C multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in decreased expression of CDC25C protein] CTD PMID:38104654 NCBI chr 2:140,289,156...140,323,696
Ensembl chr 2:140,289,115...140,324,425
JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in decreased expression of CDK1 protein] CTD PMID:38104654 NCBI chr14:64,233,945...64,255,290
Ensembl chr14:64,233,987...64,372,197
JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions EXP Caffeine inhibits the reaction [deoxynivalenol results in increased phosphorylation of CHEK2 protein] CTD PMID:38104654 NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,929,715...45,967,290
JBrowse link
G RYR1 ryanodine receptor 1 increases activity
multiple interactions
EXP Caffeine results in increased activity of RYR1 protein; Caffeine results in increased activity of RYR1 protein mutant form
Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]
CTD PMID:11278295 NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458
JBrowse link
Calphostin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions EXP calphostin C inhibits the reaction [Clofibrate results in increased expression of NOS3 protein] CTD PMID:17105827 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
EXP calphostin C results in decreased expression of PPARA
calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA protein]; calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA]; calphostin C promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PPARA]
CTD PMID:17105827 PMID:20568414 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239
JBrowse link
capsazepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions EXP capsazepine inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]] CTD PMID:18230619 NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,713,977
JBrowse link
carvacrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 increases activity EXP carvacrol results in increased activity of RYR1 protein CTD PMID:17641978 NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458
JBrowse link
catechol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase multiple interactions EXP [S-Adenosylmethionine analog co-treated with COMT protein] results in increased methylation of catechol CTD PMID:20196537 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998
JBrowse link
CCCP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPX4 glutathione peroxidase 4 multiple interactions EXP Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [Diquat results in decreased expression of GPX4 mRNA] CTD PMID:38567716 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931
JBrowse link
chlorogenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP Chlorogenic Acid results in decreased activity of COMT protein CTD PMID:27270453 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL8 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] CTD PMID:27861533 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:27861533 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:27861533 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:27861533 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
chloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPD1 protein] CTD PMID:17727805 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,526
JBrowse link
G IFIT3 interferon induced protein with tetratricopeptide repeats 3 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFIT1 mRNA] CTD PMID:27079946 NCBI chr14:101,237,403...101,249,486
Ensembl chr14:101,237,571...101,249,498
JBrowse link
G IFNB1 interferon beta 1 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNB1 mRNA] CTD PMID:27079946 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495
JBrowse link
G IFNG interferon gamma multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNG mRNA] CTD PMID:27079946 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670
JBrowse link
G IL12B interleukin 12B multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL12B mRNA] CTD PMID:27079946 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,143,268...64,158,929
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL6 mRNA] CTD PMID:27079946 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G IRF7 interferon regulatory factor 7 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IRF7 mRNA] CTD PMID:27079946 NCBI chr 2:372,235...375,572
Ensembl chr 2:372,238...375,378
JBrowse link
G ISG15 ISG15 ubiquitin like modifier multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of ISG15 mRNA] CTD PMID:27079946 NCBI chr 6:63,363,201...63,364,211
Ensembl chr 6:63,363,173...63,364,208
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL1B mRNA] CTD PMID:27079946
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein] CTD PMID:30287338 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of RELA protein] CTD PMID:27079946 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
JBrowse link
G SQSTM1 sequestosome 1 increases expression
multiple interactions
EXP Chloroquine results in increased expression of SQSTM1 protein
Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein]
CTD PMID:30287338 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938
JBrowse link
G TLR7 toll like receptor 7 multiple interactions EXP Chloroquine affects the localization of and results in decreased activity of TLR7 protein CTD PMID:27079946 NCBI chr  X:9,573,178...9,576,987 JBrowse link
chlorotoluron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B decreases response to substance EXP CYP2B6B protein results in decreased susceptibility to chlortoluron CTD PMID:16315095 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334
JBrowse link
G CYP2C49 cytochrome P450 2C49 decreases response to substance EXP CYP2C49 protein results in decreased susceptibility to chlortoluron CTD PMID:16315095 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455
JBrowse link
chlortetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions
increases uptake
EXP Chlortetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
JBrowse link
cinaciguat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein] CTD PMID:19466990 NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,290...44,518,135
JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein] CTD PMID:19466990 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687
JBrowse link
clofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 increases expression EXP Clofibrate results in increased expression of ACO1 mRNA CTD PMID:17363680 NCBI chr10:33,937,833...34,001,895
Ensembl chr10:33,937,833...34,001,900
JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression EXP Clofibrate results in increased expression of ACOX1 mRNA CTD PMID:16896063 PMID:17437637 NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,439,361...5,479,546
JBrowse link
G AGT angiotensinogen multiple interactions EXP Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
JBrowse link
G ALB albumin decreases expression EXP Clofibrate results in decreased expression of ALB mRNA CTD PMID:16896063 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Clofibrate results in increased expression of BAX mRNA CTD PMID:17437637 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP Clofibrate results in decreased expression of BCL2L1 mRNA CTD PMID:17437637 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694
JBrowse link
G CAT catalase increases expression EXP Clofibrate results in increased expression of CAT mRNA CTD PMID:17437637 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression EXP Clofibrate results in increased expression of CPT1A mRNA CTD PMID:16896063 PMID:17363680 NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,911
JBrowse link
G CTSB cathepsin B increases expression EXP Clofibrate results in increased expression of CTSB mRNA CTD PMID:16896063 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,033,877
JBrowse link
G DIO2 iodothyronine deiodinase 2 decreases expression EXP Clofibrate results in decreased expression of DIO2 mRNA CTD PMID:16896063 NCBI chr 7:103,096,414...103,110,749
Ensembl chr 7:103,096,433...103,323,258
JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions
EXP Clofibrate results in decreased expression of EDN1 protein
Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein]; Nitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]
CTD PMID:17105827 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G FABP1 fatty acid binding protein 1 increases expression EXP Clofibrate results in increased expression of FABP1 mRNA CTD PMID:17363680 NCBI chr 3:57,850,511...57,854,966
Ensembl chr 3:57,850,499...57,854,956
JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression EXP Clofibrate results in decreased expression of GPX1 mRNA CTD PMID:17437637 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression EXP Clofibrate results in increased expression of HMGCS2 mRNA CTD PMID:17363680 NCBI chr 4:101,420,941...101,440,302
Ensembl chr 4:101,420,872...101,438,126
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Clofibrate results in increased expression of JUN mRNA CTD PMID:17437637 NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636
JBrowse link
G KNG1 kininogen 1 multiple interactions EXP Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP Clofibrate results in increased expression of MYC mRNA CTD PMID:17437637 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078
JBrowse link
G NOS3 nitric oxide synthase 3 increases expression
multiple interactions
EXP Clofibrate results in increased expression of NOS3 protein
calphostin C inhibits the reaction [Clofibrate results in increased expression of NOS3 protein]
CTD PMID:17105827 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha increases expression
multiple interactions
EXP Clofibrate results in increased expression of PPARA; Clofibrate results in increased expression of PPARA protein
calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA protein]; calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA]; Tetradecanoylphorbol Acetate inhibits the reaction [Clofibrate results in increased expression of PPARA]
CTD PMID:17105827 PMID:20568414 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239
JBrowse link
G SCD stearoyl-CoA desaturase increases expression EXP Clofibrate results in increased expression of SCD mRNA CTD PMID:17363680 NCBI chr14:111,461,560...111,478,033
Ensembl chr14:111,461,569...111,478,020
JBrowse link
G SLC5A5 solute carrier family 5 member 5 increases expression EXP Clofibrate results in increased expression of SLC5A5 mRNA CTD PMID:16896063 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,155...59,885,266
JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP Clofibrate results in increased expression of SOD1 mRNA CTD PMID:17437637 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
G THRA thyroid hormone receptor alpha decreases expression EXP Clofibrate results in decreased expression of THRA mRNA CTD PMID:16896063 NCBI chr12:22,270,506...22,296,684
Ensembl chr12:22,270,062...22,296,618
JBrowse link
G TNF tumor necrosis factor decreases expression EXP Clofibrate results in decreased expression of TNF mRNA CTD PMID:17437637 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
G TPO thyroid peroxidase increases expression EXP Clofibrate results in increased expression of TPO mRNA CTD PMID:16896063 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208
JBrowse link
G TSHR thyroid stimulating hormone receptor increases expression EXP Clofibrate results in increased expression of TSHR mRNA CTD PMID:16896063 NCBI chr 7:103,768,260...103,925,777
Ensembl chr 7:103,768,296...103,925,922
JBrowse link
G TTR transthyretin decreases expression EXP Clofibrate results in decreased expression of TTR mRNA CTD PMID:16896063 NCBI chr 6:115,496,338...115,503,974
Ensembl chr 6:115,496,326...115,503,977
JBrowse link
clorgyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAOA monoamine oxidase A decreases activity EXP Clorgyline analog results in decreased activity of MAOA protein CTD PMID:33359020 NCBI chr  X:38,930,452...39,006,220 JBrowse link
cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions
EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]
CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
coumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2A19 cytochrome P450 family 2 subfamily A member 19 increases hydroxylation
multiple interactions
EXP CYP2A19 protein results in increased hydroxylation of coumarin
2-aminoacetophenone inhibits the reaction [[CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin]; 2-aminoacetophenone inhibits the reaction [CYP2A19 protein results in increased hydroxylation of coumarin]; [CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin; Skatole inhibits the reaction [[CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin]; Skatole inhibits the reaction [CYP2A19 protein results in increased hydroxylation of coumarin]
CTD PMID:30599194 NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107
JBrowse link
crizotinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NTRK1 neurotrophic receptor tyrosine kinase 1 decreases activity EXP Crizotinib results in decreased activity of NTRK1 protein CTD PMID:21812414 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,255,981
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 decreases activity EXP Crizotinib results in decreased activity of NTRK2 protein CTD PMID:21812414 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,405...30,429,882
JBrowse link
curcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO2 aconitase 2 multiple interactions EXP Curcumin inhibits the reaction [maleic acid results in decreased activity of ACO2 protein] CTD PMID:25119790 NCBI chr 5:7,014,383...7,071,023
Ensembl chr 5:7,008,719...7,071,025
JBrowse link
cyanocob(III)alamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein CTD PMID:29129240 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA CTD PMID:28445388 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA CTD PMID:28445388 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA CTD PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA CTD PMID:28445388 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820
JBrowse link
G SI sucrase-isomaltase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA CTD PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
daidzein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 increases expression EXP daidzein results in increased expression of ESR1 mRNA CTD PMID:19617652 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 increases expression EXP daidzein results in increased expression of ESR2 mRNA; daidzein results in increased expression of ESR2 protein CTD PMID:19617652 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions EXP daidzein inhibits the reaction [LHB protein results in increased abundance of Progesterone] CTD PMID:19617652 NCBI chr 6:54,263,574...54,269,286
Ensembl chr 6:54,263,576...54,271,086
JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Penicillins]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
JBrowse link
DDE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 decreases expression
multiple interactions
EXP Dichlorodiphenyl Dichloroethylene results in decreased expression of CYP11A1 mRNA
Dichlorodiphenyl Dichloroethylene inhibits the reaction [Cholera Toxin results in increased expression of CYP11A1 mRNA]
CTD PMID:11226075 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP19A3 cytochrome P450 19A3 increases activity EXP Dichlorodiphenyl Dichloroethylene results in increased activity of CYP19A1 protein CTD PMID:18195494 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
deguelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP deguelin results in increased expression of and results in increased phosphorylation of AKT1 protein CTD PMID:37353039
G PDK1 pyruvate dehydrogenase kinase 1 multiple interactions EXP deguelin results in increased expression of and results in increased phosphorylation of PDK1 protein CTD PMID:37353039 NCBI chr15:78,608,394...78,650,958
Ensembl chr15:78,608,432...78,652,962
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP deguelin results in increased expression of and results in increased phosphorylation of PIK3R1 protein CTD PMID:37353039 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions EXP deguelin results in increased expression of and results in increased phosphorylation of PTEN protein CTD PMID:37353039 NCBI chr14:99,929,590...100,021,619 JBrowse link
diazinon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity EXP Diazinon results in decreased activity of ACHE protein CTD PMID:21467751 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605
JBrowse link
dicoumarol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Dicumarol inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]] CTD PMID:20732396 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
JBrowse link
diquat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase affects activity
decreases activity
multiple interactions
decreases expression
EXP Diquat affects the activity of CAT protein
Diquat results in decreased activity of CAT protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Diquat results in decreased activity of CAT protein]; [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of CAT mRNA]
CTD PMID:22558963 PMID:32280687 PMID:38567716 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CLDN1 claudin 1 decreases expression EXP Diquat results in decreased expression of CLDN1 protein CTD PMID:26338884 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657
JBrowse link
G CLDN3 claudin 3 decreases expression
multiple interactions
EXP Diquat results in decreased expression of CLDN3 protein
Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN3 protein]
CTD PMID:26338884 NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102
JBrowse link
G CLDN4 claudin 4 decreases expression
multiple interactions
EXP Diquat results in decreased expression of CLDN4 protein
Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN4 protein]
CTD PMID:26338884 NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Diquat results in increased expression of DDIT3 protein CTD PMID:38567716 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP Diquat results in increased phosphorylation of EIF2AK3 protein CTD PMID:38567716 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Diquat results in increased phosphorylation of EIF2S1 protein CTD PMID:38567716 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
decreases expression
EXP 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]; [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA] CTD PMID:32280687 PMID:38567716 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G GPX4 glutathione peroxidase 4 decreases expression
multiple interactions
EXP Diquat results in decreased expression of GPX4 mRNA
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Diquat results in decreased expression of GPX4 mRNA]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [Diquat results in decreased expression of GPX4 mRNA]
CTD PMID:38567716 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Diquat results in increased expression of HSPA5 protein CTD PMID:38567716 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
G LOC110258578 interleukin-1 beta-like increases expression
multiple interactions
EXP Diquat results in increased expression of IL1B mRNA
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of IL1B mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in increased expression of IL1B mRNA]
CTD PMID:32280687
G NFE2L2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions
EXP Diquat results in decreased expression of NFE2L2 mRNA
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]
CTD PMID:32280687 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
G OCLN occludin increases expression EXP Diquat results in increased expression of OCLN protein CTD PMID:26338884 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033
JBrowse link
G PPP1R16A protein phosphatase 1 regulatory subunit 16A increases activity EXP Diquat results in increased activity of GPT protein CTD PMID:38567716 NCBI chr 4:302,621...320,048
Ensembl chr 4:297,748...320,056
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
decreases expression
EXP 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA]; [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA] CTD PMID:32280687 PMID:38567716 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase increases expression EXP Diquat results in increased expression of TDO2 mRNA CTD PMID:22558963 NCBI chr 8:44,708,722...44,725,954
Ensembl chr 8:44,708,746...44,740,962
JBrowse link
G TJP1 tight junction protein 1 decreases expression EXP Diquat results in decreased expression of TJP1 protein CTD PMID:26338884 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836
JBrowse link
G TJP2 tight junction protein 2 multiple interactions
decreases expression
EXP Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP2 protein] CTD PMID:26338884 NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983
JBrowse link
G TJP3 tight junction protein 3 decreases expression
multiple interactions
EXP Diquat results in decreased expression of TJP3 protein
Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP3 protein]
CTD PMID:26338884 NCBI chr 2:74,938,153...74,971,431
Ensembl chr 2:74,938,152...74,971,531
JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions
EXP Diquat results in increased expression of TNF mRNA
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of TNF mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in increased expression of TNF mRNA]
CTD PMID:32280687 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
dobutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HK2 hexokinase 2 decreases expression EXP Dobutamine results in decreased expression of HK2 protein CTD PMID:19944370 NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,153,835...68,231,615
JBrowse link
G NOS2 nitric oxide synthase 2 affects response to substance EXP NOS2 protein affects the susceptibility to Dobutamine CTD PMID:20141602 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146
JBrowse link
G PYGM glycogen phosphorylase, muscle associated decreases expression EXP Dobutamine results in decreased expression of PYGM protein CTD PMID:19944370 NCBI chr 2:7,409,330...7,421,256
Ensembl chr 2:7,409,116...7,421,254
JBrowse link
doxorubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 decreases expression EXP Doxorubicin results in decreased expression of GJA1 protein CTD PMID:32877659 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156
JBrowse link
G MMP1 matrix metallopeptidase 1 increases activity
increases expression
EXP Doxorubicin results in increased activity of MMP1 protein
Doxorubicin results in increased expression of MMP1 mRNA
CTD PMID:19782292 NCBI chr 9:33,411,738...33,420,205
Ensembl chr 9:33,411,065...33,420,076
JBrowse link
G MMP14 matrix metallopeptidase 14 increases expression
increases activity
EXP Doxorubicin results in increased expression of MMP14 mRNA
Doxorubicin results in increased activity of MMP14 protein
CTD PMID:19782292 NCBI chr 7:76,174,502...76,185,931
Ensembl chr 7:76,172,971...76,185,928
JBrowse link
G MMP2 matrix metallopeptidase 2 increases expression
increases activity
EXP Doxorubicin results in increased expression of MMP2 mRNA
Doxorubicin results in increased activity of MMP2 protein
CTD PMID:19782292 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982
JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression
increases activity
EXP Doxorubicin results in increased expression of MMP9 mRNA
Doxorubicin results in increased activity of MMP9 protein
CTD PMID:19782292 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788
JBrowse link
G TNF tumor necrosis factor decreases expression EXP Doxorubicin results in decreased expression of TNF mRNA CTD PMID:15810080 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
G TNNT2 troponin T2, cardiac type decreases expression EXP Doxorubicin results in decreased expression of TNNT2 protein CTD PMID:32877659 NCBI chr10:23,749,528...23,759,696
Ensembl chr10:23,749,335...23,763,396
JBrowse link
doxycycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 increases uptake
multiple interactions
EXP SLCO1A2 protein results in increased uptake of Doxycycline
Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]
CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
JBrowse link
esculetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression EXP esculetin results in increased expression of CYP1A2 mRNA CTD PMID:24176340 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100
JBrowse link
estrone 3-sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 increases uptake
multiple interactions
EXP SLCO1A2 protein results in increased uptake of estrone sulfate
Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; cefquinome inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Chlortetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Clarithromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Erythromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Penicillins inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Tetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; tilmicosin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Tylosin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]
CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
JBrowse link
fenofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 affects localization EXP Fenofibrate affects the localization of ABCA1 protein CTD PMID:16530456 NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492
JBrowse link
G APOA1 apolipoprotein A1 increases secretion
decreases expression
multiple interactions
EXP Fenofibrate results in increased secretion of APOA1 protein
Fenofibrate results in decreased expression of APOA1 mRNA
Fenofibrate inhibits the reaction [APOA1 protein results in increased transport of Cholesterol]; Fenofibrate promotes the reaction [APOA1 protein results in increased transport of Cholesterol]
CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713
JBrowse link
G SCARB1 scavenger receptor class B member 1 affects localization EXP Fenofibrate affects the localization of SCARB1 protein CTD PMID:16530456 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,568
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [Fenofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein] CTD PMID:15226458 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
ferroheme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMOX1 heme oxygenase 1 increases metabolic processing
multiple interactions
EXP HMOX1 protein results in increased metabolism of Heme
[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide; chromium mesoporphyrin inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]; tin protoporphyrin IX inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]
CTD PMID:16751286
fisetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP [bisphenol A co-treated with fisetin] results in increased expression of CASP3 mRNA CTD PMID:29544186 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 multiple interactions EXP [bisphenol A co-treated with fisetin] results in decreased expression of CYP11A1 mRNA; fisetin promotes the reaction [bisphenol A results in decreased expression of CYP11A1 mRNA] CTD PMID:29544186 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP bisphenol A promotes the reaction [fisetin inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]]; fisetin inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; fisetin promotes the reaction [bisphenol A inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]] CTD PMID:29544186 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions
decreases expression
EXP bisphenol A promotes the reaction [fisetin results in decreased expression of HSD3B1 mRNA]; fisetin promotes the reaction [bisphenol A results in decreased expression of HSD3B1 mRNA] CTD PMID:29544186 NCBI chr 4:101,565,229...101,574,110 JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions EXP [bisphenol A co-treated with fisetin] results in decreased expression of STAR mRNA; fisetin promotes the reaction [bisphenol A results in decreased expression of STAR mRNA] CTD PMID:29544186 NCBI chr15:48,377,597...48,385,398
Ensembl chr15:48,377,521...48,385,462
JBrowse link
flavones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP [Flavones co-treated with Lipopolysaccharides] results in increased phosphorylation of AKT1 protein CTD PMID:31669396
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Flavones inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein] CTD PMID:31669396 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G CASP3 caspase 3 multiple interactions EXP Flavones inhibits the reaction [Lipopolysaccharides results in increased expression of CASP3 protein] CTD PMID:31669396 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Flavones co-treated with Lipopolysaccharides] results in increased phosphorylation of RELA protein CTD PMID:31669396 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
JBrowse link
flavonol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases expression EXP 3-hydroxyflavone results in decreased expression of CASP3 protein CTD PMID:21126572 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases expression EXP 3-hydroxyflavone results in increased expression of MAPK1 protein CTD PMID:21126572 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases expression EXP 3-hydroxyflavone results in increased expression of MAPK3 protein CTD PMID:21126572 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
flutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 affects expression EXP Flutamide affects the expression of GJA1 mRNA CTD PMID:20961722 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156
JBrowse link
folic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein CTD PMID:29129240 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CBS cystathionine beta-synthase multiple interactions
increases activity
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of CBS protein
Folic Acid deficiency results in increased activity of CBS protein
CTD PMID:16792574 NCBI chr13:206,205,942...206,231,363
Ensembl chr13:206,205,946...206,230,248
JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of CSF2 mRNA CTD PMID:14662146 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G CTH cystathionine gamma-lyase multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of CTH protein CTD PMID:16792574 NCBI chr 6:142,454,922...142,486,352
Ensembl chr 6:142,454,914...142,486,367
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA CTD PMID:28445388 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA CTD PMID:28445388 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of GCLC protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GCLC mRNA CTD PMID:16792574 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA CTD PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions
increases activity
increases expression
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSR protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSR mRNA
Folic Acid deficiency results in increased activity of GSR protein
Folic Acid deficiency results in increased expression of GSR mRNA
CTD PMID:16792574 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984
JBrowse link
G GSS glutathione synthetase multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSS protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSS mRNA CTD PMID:16792574 NCBI chr17:38,316,199...38,342,253
Ensembl chr17:38,312,720...38,342,298
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions
increases expression
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSTA1 mRNA
Folic Acid deficiency results in increased expression of GSTA1 mRNA
CTD PMID:16792574 NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,548,670
JBrowse link
G GYS1 glycogen synthase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter CTD PMID:29065941 NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP [bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter CTD PMID:29065941 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715
JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA CTD PMID:28445388 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of PTGS1 CTD PMID:14662146 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in increased expression of PTGS2 CTD PMID:14662146 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
G SI sucrase-isomaltase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841
JBrowse link
G SOD1 superoxide dismutase 1 decreases activity
multiple interactions
EXP Folic Acid deficiency results in decreased activity of SOD1 protein
[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA; [Ethanol co-treated with Folic Acid deficiency] results in decreased activity of SOD1 protein
CTD PMID:16792574 PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases activity
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of SOD2 protein
Folic Acid deficiency results in increased activity of SOD2 protein; Folic Acid results in increased activity of SOD2 protein
CTD PMID:16792574 PMID:22889112 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
gefitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FES FES proto-oncogene, tyrosine kinase multiple interactions
decreases phosphorylation
EXP Gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein]; Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein]
Gefitinib results in decreased phosphorylation of FES protein
CTD PMID:19885553 NCBI chr 7:53,472,947...53,485,084
Ensembl chr 7:53,472,947...53,485,082
JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions EXP Gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein] CTD PMID:19885553 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein] CTD PMID:19885553 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366
JBrowse link
genistein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 decreases expression EXP Genistein results in decreased expression of ESR1 protein CTD PMID:22443950 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Genistein inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Penicillins]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Genistein inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions EXP Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein] CTD PMID:18840580 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
GSK2656157 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 multiple interactions EXP GSK2656157 inhibits the reaction [deoxynivalenol results in increased expression of ATF4 protein] CTD PMID:37442268 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP GSK2656157 inhibits the reaction [deoxynivalenol results in increased expression of DDIT3 protein] CTD PMID:37442268 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A multiple interactions EXP GSK2656157 inhibits the reaction [deoxynivalenol results in increased phosphorylation of EIF2A protein] CTD PMID:37442268 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,274
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP GSK2656157 inhibits the reaction [deoxynivalenol results in increased phosphorylation of EIF2AK3 protein] CTD PMID:37442268 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245
JBrowse link
haloperidol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions EXP Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein] CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
heme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMOX1 heme oxygenase 1 increases metabolic processing
multiple interactions
EXP HMOX1 protein results in increased metabolism of Heme
[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide; chromium mesoporphyrin inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]; tin protoporphyrin IX inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]
CTD PMID:16751286
hexachlorobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions EXP Hexachlorobenzene inhibits the reaction [ADIPOQ protein results in increased secretion of Estradiol]; Hexachlorobenzene results in decreased expression of and results in decreased secretion of ADIPOQ protein CTD PMID:28284726 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646
JBrowse link
G ADIPOR1 adiponectin receptor 1 decreases expression EXP Hexachlorobenzene results in decreased expression of ADIPOR1 protein CTD PMID:28284726 NCBI chr10:24,907,491...24,923,540
Ensembl chr10:24,907,491...24,915,686
JBrowse link
G ADIPOR2 adiponectin receptor 2 decreases expression EXP Hexachlorobenzene results in decreased expression of ADIPOR2 protein CTD PMID:28284726 NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 increases expression EXP Hexachlorobenzene results in increased expression of CYP11A1 protein CTD PMID:21296658 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 decreases expression EXP Hexachlorobenzene results in decreased expression of CYP17A1 protein CTD PMID:21296658 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041
JBrowse link
G CYP19A3 cytochrome P450 19A3 decreases expression EXP Hexachlorobenzene results in decreased expression of CYP19A1 protein CTD PMID:21296658 NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 decreases expression EXP Hexachlorobenzene results in decreased expression of HSD17B1 protein CTD PMID:21296658 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,271,548
JBrowse link
histamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HRH2 histamine receptor H2 multiple interactions EXP [Histamine affects the activity of HRH2 protein] which affects the secretion of Chlorides CTD PMID:12665126 NCBI chr 2:81,883,670...81,932,464
Ensembl chr 2:81,883,673...81,932,275
JBrowse link
hydroxytyrosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] CTD PMID:21798251 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] CTD PMID:21798251 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
hypoxanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP CAT protein inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; CAT protein results in decreased activity of [Hypoxanthine co-treated with XDH protein] CTD PMID:21984542 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G XDH xanthine dehydrogenase multiple interactions EXP [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide; [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Hydrogen Peroxide; [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Superoxides; CAT protein inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; CAT protein results in decreased activity of [Hypoxanthine co-treated with XDH protein]; tempol inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; tempol results in decreased activity of [Hypoxanthine co-treated with XDH protein] CTD PMID:21984542 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169
JBrowse link
indometacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity