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G |
Hmbs |
hydroxymethylbilane synthase |
decreases activity |
ISO |
Aluminium ion decreases activity of purified Hmbs protein |
RGD |
PMID:6732900 |
RGD:25394584 |
NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525
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G |
Ace |
angiotensin I converting enzyme |
decreases activity |
EXP |
Aluminum results in decreased activity of ACE protein |
CTD |
PMID:12008977 |
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NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
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G |
Ache |
acetylcholinesterase |
multiple interactions decreases activity |
ISO |
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium co-treated with Zinc] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased activity of ACHE protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA; Aluminum promotes the reaction [Lead results in decreased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA]; Copper inhibits the reaction [Aluminum results in decreased activity of ACHE protein]; Plant Extracts inhibits the reaction [Aluminum results in decreased activity of ACHE protein] |
CTD |
PMID:15266904 PMID:23354609 PMID:24486960 PMID:29170048 PMID:37415728 |
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NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
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G |
Acly |
ATP citrate lyase |
multiple interactions |
ISO |
Aluminum results in increased expression of and results in increased activity of ACLY protein |
CTD |
PMID:17762189 |
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NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826
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G |
Aco1 |
aconitase 1 |
decreases activity |
ISO |
Aluminum results in decreased activity of ACO1 protein |
CTD |
PMID:10806405 |
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NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338
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G |
Aco2 |
aconitase 2, mitochondrial |
decreases activity multiple interactions |
EXP ISO |
Aluminum results in decreased activity of ACO2 protein Aluminum promotes the reaction [Nitroprusside results in decreased activity of ACO2 protein] Aluminum results in decreased expression of and results in decreased activity of ACO2 protein |
CTD |
PMID:12470706 PMID:16906525 PMID:19010380 |
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NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334
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G |
Alb |
albumin |
affects binding |
ISO |
ALB protein binds to Aluminum |
CTD |
PMID:14507469 |
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NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions increases expression |
ISO |
caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein] Aluminum results in increased expression of ALOX5 mRNA; Aluminum results in increased expression of ALOX5 protein |
CTD |
PMID:27368151 |
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NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
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G |
Alpl |
alkaline phosphatase, liver/bone/kidney |
multiple interactions |
EXP |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of ALPL mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of ALPL mRNA] |
CTD |
PMID:34547296 |
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NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
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G |
Apob |
apolipoprotein B |
increases expression |
ISO |
Aluminum results in increased expression of APOB protein |
CTD |
PMID:17762189 |
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NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835
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G |
App |
amyloid beta precursor protein |
affects binding multiple interactions increases expression increases cleavage |
ISO EXP |
APP protein binds to Aluminum [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] [APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA Aluminum results in increased expression of APP mRNA APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]; meloxicam inhibits the reaction [Aluminum results in increased expression of APP protein]; Vitamin E inhibits the reaction [Aluminum results in increased cleavage of APP protein] |
CTD |
PMID:12039845 PMID:16308480 PMID:16724269 PMID:16928369 PMID:16942756 PMID:21298039 PMID:29170048 More...
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NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
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G |
Atxn3 |
ataxin 3 |
affects folding multiple interactions |
EXP ISO |
Aluminum affects the folding of ATXN3 protein polymorphism Aluminum promotes the reaction [ATXN3 protein polymorphism binds to ATXN3 protein polymorphism] |
CTD |
PMID:17300980 |
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NCBI chr12:101,885,160...101,928,139
Ensembl chr12:101,885,160...101,924,505
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G |
Bax |
BCL2-associated X protein |
affects response to substance multiple interactions |
ISO EXP |
BAX protein affects the susceptibility to Aluminum [aluminum chlorhydrate results in increased abundance of Aluminum] which affects the expression of BAX protein [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX protein] |
CTD |
PMID:20385067 PMID:31945389 PMID:34547296 |
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NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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G |
Bbox1 |
gamma-butyrobetaine hydroxylase 1 |
multiple interactions decreases expression |
ISO |
Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Ketoglutaric Acids inhibits the reaction [Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]] Aluminum results in decreased expression of BBOX1 protein |
CTD |
PMID:21439360 |
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NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905
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G |
Bcl2 |
B cell leukemia/lymphoma 2 |
multiple interactions |
ISO EXP |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein; Fulvestrant inhibits the reaction [[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein] [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein] |
CTD |
PMID:31945389 PMID:34547296 |
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NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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G |
Bcl2l1 |
BCL2-like 1 |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2L1 protein |
CTD |
PMID:31945389 |
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NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
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G |
Bglap |
bone gamma carboxyglutamate protein |
multiple interactions decreases secretion |
ISO EXP |
Aluminum inhibits the reaction [Calcitriol results in increased secretion of BGLAP protein]; Calcitriol inhibits the reaction [Aluminum results in decreased secretion of BGLAP protein] [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP protein] |
CTD |
PMID:9626627 PMID:34547296 |
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NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771
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G |
Bgn |
biglycan |
increases expression |
EXP |
Aluminum results in increased expression of BGN mRNA |
CTD |
PMID:37544489 |
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NCBI chr X:72,527,207...72,539,542
Ensembl chr X:72,527,208...72,539,539
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G |
Cald1 |
caldesmon 1 |
increases expression |
EXP |
Aluminum results in increased expression of CALD1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408
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G |
Casp12 |
caspase 12 |
multiple interactions |
EXP |
[aluminum chloride results in increased abundance of Aluminum] which results in increased expression of CASP12 mRNA |
CTD |
PMID:29635646 |
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NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032
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G |
Casp3 |
caspase 3 |
increases expression multiple interactions |
EXP ISO |
Aluminum results in increased expression of CASP3 [Aluminum Chloride results in increased abundance of Aluminum] which results in increased cleavage of CASP3 protein; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CASP3 mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CASP3 mRNA] [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of CASP3 protein |
CTD |
PMID:21972528 PMID:34547296 PMID:37415728 |
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of CASP9 protein; Fulvestrant inhibits the reaction [[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of CASP9 protein] |
CTD |
PMID:31945389 |
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NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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G |
Casr |
calcium-sensing receptor |
multiple interactions |
ISO |
[Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; [Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates; Aluminum binds to and results in increased activity of CASR protein |
CTD |
PMID:10231437 |
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NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503
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G |
Cat |
catalase |
decreases activity multiple interactions |
ISO EXP |
Aluminum results in decreased activity of CAT protein [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased activity of CAT protein] [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased activity of CAT protein; CAT protein results in decreased susceptibility to [Tyramine co-treated with Aluminum]; Plant Extracts inhibits the reaction [Aluminum results in decreased activity of CAT protein] Vitamin E inhibits the reaction [Aluminum results in decreased activity of CAT protein] |
CTD |
PMID:15526171 PMID:17709913 PMID:24486960 PMID:34547296 PMID:37415728 |
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NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
decreases expression |
EXP |
Aluminum results in decreased expression of CCL7 mRNA |
CTD |
PMID:37544489 |
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NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 protein |
CTD |
PMID:32437896 |
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NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
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G |
Chat |
choline O-acetyltransferase |
decreases expression decreases activity multiple interactions |
EXP |
Aluminum results in decreased expression of CHAT protein Aluminum results in decreased activity of CHAT protein APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]; meloxicam inhibits the reaction [Aluminum results in decreased expression of CHAT protein] |
CTD |
PMID:16724269 PMID:16928369 |
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NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
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G |
Col1a1 |
collagen, type I, alpha 1 |
multiple interactions decreases expression |
EXP |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of COL1A1 mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of COL1A1 mRNA] Aluminum results in decreased expression of COL1A1 mRNA |
CTD |
PMID:34547296 PMID:37544489 |
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NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
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G |
Crp |
C-reactive protein, pentraxin-related |
multiple interactions |
ISO |
[Zinc co-treated with Aluminum] results in increased expression of CRP protein; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of CRP protein |
CTD |
PMID:27816692 |
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NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
increases expression |
EXP |
Aluminum results in increased expression of CX3CL1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055
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G |
Cxcl15 |
C-X-C motif chemokine ligand 15 |
increases expression |
ISO |
Aluminum analog results in increased expression of CXCL8 mRNA |
CTD |
PMID:23724284 |
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NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
EXP |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CYCS mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CYCS mRNA] |
CTD |
PMID:34547296 |
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NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
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G |
Daxx |
Fas death domain-associated protein |
increases expression |
ISO |
Aluminum results in increased expression of DAXX mRNA |
CTD |
PMID:16308480 |
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NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564
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G |
Drd1 |
dopamine receptor D1 |
multiple interactions |
ISO |
Aluminum inhibits the reaction [SCH 23390 binds to DRD1 protein] |
CTD |
PMID:9109525 |
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NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
ISO |
Aluminum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein] |
CTD |
PMID:9109525 |
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NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
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G |
Ecm1 |
extracellular matrix protein 1 |
increases expression |
EXP |
Aluminum results in increased expression of ECM1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 3:95,641,459...95,646,880
Ensembl chr 3:95,641,459...95,646,881
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G |
Egln3 |
egl-9 family hypoxia-inducible factor 3 |
increases expression |
EXP |
Aluminum results in increased expression of EGLN3 mRNA; Aluminum results in increased expression of EGLN3 protein |
CTD |
PMID:37544489 |
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NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646
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G |
Eno2 |
enolase 2, gamma neuronal |
decreases activity |
ISO |
Aluminum results in decreased activity of ENO2 protein |
CTD |
PMID:11860913 |
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NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636
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G |
Epor |
erythropoietin receptor |
affects expression |
ISO |
Aluminum affects the expression of EPOR protein |
CTD |
PMID:15777837 |
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NCBI chr 9:21,870,193...21,874,915
Ensembl chr 9:21,870,193...21,874,802
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G |
Esr1 |
estrogen receptor 1 (alpha) |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; [aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [NRG1 protein results in increased phosphorylation of ESR1 protein]; [aluminum chlorhydrate results in increased abundance of Aluminum] which results in increased expression of ESR1 protein; [Estradiol co-treated with [aluminum chlorhydrate results in increased abundance of Aluminum]] results in increased expression of ESR1 protein |
CTD |
PMID:31945389 |
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NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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G |
Esr2 |
estrogen receptor 2 (beta) |
multiple interactions |
ISO |
[[aluminum chlorhydrate results in increased abundance of Aluminum] co-treated with [Tretinoin co-treated with Estradiol]] affects the localization of ESR2 protein; [[aluminum chlorhydrate results in increased abundance of Aluminum] which co-treated with Tretinoin] results in decreased expression of and affects the localization of ESR2 protein; [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of and affects the localization of ESR2 protein; [Estradiol co-treated with [aluminum chlorhydrate results in increased abundance of Aluminum]] results in decreased expression of ESR2 protein |
CTD |
PMID:31945389 |
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NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
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G |
F8 |
coagulation factor VIII |
affects folding multiple interactions |
ISO |
Aluminum affects the folding of F8 protein [Aluminum promotes the reaction [F8 protein binds to F8 protein]] which results in decreased activity of F8 protein |
CTD |
PMID:15349964 |
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NCBI chr X:74,213,950...74,426,342
Ensembl chr X:74,216,321...74,426,221
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G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
increases expression |
EXP |
Aluminum results in increased expression of FDFT1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027
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G |
Fh1 |
fumarate hydratase 1 |
multiple interactions |
ISO |
Aluminum results in decreased expression of and results in decreased activity of FH protein |
CTD |
PMID:16906525 |
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NCBI chr 1:175,428,944...175,453,201
Ensembl chr 1:175,427,940...175,453,201
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G |
Fos |
FBJ osteosarcoma oncogene |
multiple interactions |
EXP |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein] |
CTD |
PMID:23690655 |
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NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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G |
Fosl1 |
fos-like antigen 1 |
increases expression |
EXP |
Aluminum results in increased expression of FOSL1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974
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G |
G6pdx |
glucose-6-phosphate dehydrogenase X-linked |
increases activity |
ISO |
Aluminum results in increased activity of G6PD protein |
CTD |
PMID:16572710 PMID:16979867 |
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NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
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G |
Gbp3 |
guanylate binding protein 3 |
decreases expression |
EXP |
Aluminum results in decreased expression of GBP3 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 3:142,265,781...142,278,974
Ensembl chr 3:142,265,787...142,278,970
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G |
Gchfr |
GTP cyclohydrolase I feedback regulator |
increases expression |
EXP |
Aluminum results in increased expression of GCHFR mRNA |
CTD |
PMID:37544489 |
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NCBI chr 2:118,998,269...119,002,870
Ensembl chr 2:118,998,254...119,002,871
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G |
Gfap |
glial fibrillary acidic protein |
increases expression multiple interactions |
ISO EXP |
Aluminum results in increased expression of GFAP protein Vitamin E inhibits the reaction [Aluminum results in increased expression of GFAP protein] [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of GFAP protein |
CTD |
PMID:16545059 PMID:31363819 |
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NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
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G |
Gnai1 |
G protein subunit alpha i1 |
decreases expression |
ISO |
Aluminum results in decreased expression of GNAI1 protein |
CTD |
PMID:9626627 |
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NCBI chr 5:18,470,133...18,565,411
Ensembl chr 5:18,470,133...18,565,353
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G |
Gnai2 |
G protein subunit alpha i2 |
decreases expression |
ISO |
Aluminum results in decreased expression of GNAI2 protein |
CTD |
PMID:9626627 |
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NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566
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G |
Gnaq |
guanine nucleotide binding protein, alpha q polypeptide |
increases response to substance |
EXP |
GNAQ protein results in increased susceptibility to Aluminum |
CTD |
PMID:15068510 |
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NCBI chr19:16,110,048...16,365,884
Ensembl chr19:16,110,195...16,364,827
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G |
Gpd1 |
glycerol-3-phosphate dehydrogenase 1 (soluble) |
multiple interactions |
ISO |
Aluminum results in increased expression of and results in increased activity of GPD1 protein |
CTD |
PMID:17762189 |
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NCBI chr15:99,615,468...99,622,895
Ensembl chr15:99,615,396...99,622,886
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G |
Gpx1 |
glutathione peroxidase 1 |
decreases activity multiple interactions |
ISO |
Aluminum results in decreased activity of GPX1 protein Vitamin E inhibits the reaction [Aluminum results in decreased activity of GPX1 protein] |
CTD |
PMID:17709913 |
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NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
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G |
Gsr |
glutathione reductase |
decreases expression multiple interactions |
ISO |
Aluminum results in decreased expression of GSR protein Plant Extracts inhibits the reaction [Aluminum results in decreased expression of GSR protein] |
CTD |
PMID:24486960 |
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NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
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G |
H2-T22 |
histocompatibility 2, T region locus 22 |
decreases expression |
EXP |
Aluminum results in decreased expression of H2-T22 mRNA |
CTD |
PMID:37544489 |
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NCBI chr17:36,348,023...36,353,635
Ensembl chr17:36,348,020...36,353,639
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G |
Hif1a |
hypoxia inducible factor 1, alpha subunit |
increases localization |
ISO |
Aluminum results in increased localization of HIF1A protein |
CTD |
PMID:16979867 |
|
NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
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G |
Hk1 |
hexokinase 1 |
multiple interactions decreases activity |
ISO |
Meclofenoxate inhibits the reaction [Aluminum results in decreased activity of HK1 protein] |
CTD |
PMID:16969689 |
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NCBI chr10:62,104,634...62,215,699
Ensembl chr10:62,104,634...62,215,687
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G |
Hmga1 |
high mobility group AT-hook 1 |
increases expression |
EXP |
Aluminum results in increased expression of HMGA1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr17:27,774,798...27,782,649
Ensembl chr17:27,775,471...27,782,648
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G |
Hmga1b |
high mobility group AT-hook 1B |
increases expression |
EXP |
Aluminum results in increased expression of HMGA1B mRNA |
CTD |
PMID:37544489 |
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NCBI chr11:120,653,620...120,655,218
Ensembl chr11:120,653,620...120,655,245
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G |
Idh1 |
isocitrate dehydrogenase 1 (NADP+), soluble |
decreases activity |
ISO |
Aluminum results in decreased activity of IDH1 protein |
CTD |
PMID:15486972 |
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NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659
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G |
Idh2 |
isocitrate dehydrogenase 2 (NADP+), mitochondrial |
decreases activity |
ISO |
Aluminum results in decreased activity of IDH2 protein |
CTD |
PMID:15486972 |
|
NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140
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G |
Ifi27l2a |
interferon, alpha-inducible protein 27 like 2A |
decreases expression |
EXP |
Aluminum results in decreased expression of IFI27L2A mRNA |
CTD |
PMID:37544489 |
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NCBI chr12:103,400,132...103,409,939
Ensembl chr12:103,408,426...103,409,939
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G |
Ifi35 |
interferon-induced protein 35 |
decreases expression |
EXP |
Aluminum results in decreased expression of IFI35 mRNA |
CTD |
PMID:37544489 |
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NCBI chr11:101,339,238...101,349,527
Ensembl chr11:101,339,233...101,349,524
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G |
Ifit1 |
interferon-induced protein with tetratricopeptide repeats 1 |
decreases expression |
EXP |
Aluminum results in decreased expression of IFIT1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr19:34,618,289...34,627,409
Ensembl chr19:34,618,271...34,627,409
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G |
Ifit3 |
interferon-induced protein with tetratricopeptide repeats 3 |
decreases expression |
EXP |
Aluminum results in decreased expression of IFIT3 mRNA |
CTD |
PMID:37544489 |
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NCBI chr19:34,560,519...34,566,382
Ensembl chr19:34,560,931...34,566,131
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G |
Ifit3b |
interferon-induced protein with tetratricopeptide repeats 3B |
decreases expression |
EXP |
Aluminum results in decreased expression of IFIT3B mRNA |
CTD |
PMID:37544489 |
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NCBI chr19:34,584,945...34,590,801
Ensembl chr19:34,585,370...34,590,801
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G |
Ifnb1 |
interferon beta 1, fibroblast |
multiple interactions |
EXP |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IFNB1 mRNA] |
CTD |
PMID:23690655 |
|
NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011
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G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO |
Aluminum inhibits the reaction [IGF1 protein results in increased activity of MTR protein] |
CTD |
PMID:14745455 |
|
NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
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G |
Igtp |
interferon gamma induced GTPase |
decreases expression |
EXP |
Aluminum results in decreased expression of IGTP mRNA |
CTD |
PMID:37544489 |
|
NCBI chr11:58,090,382...58,098,418
Ensembl chr11:58,090,382...58,098,417
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G |
Il12b |
interleukin 12b |
multiple interactions |
EXP |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B mRNA] |
CTD |
PMID:23690655 |
|
NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]; Vitamin E inhibits the reaction [Aluminum results in increased expression of IL1B protein] |
CTD |
PMID:16545059 PMID:27368151 PMID:29170048 |
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NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il4 |
interleukin 4 |
increases expression |
EXP |
Aluminum results in increased expression of IL4 mRNA |
CTD |
PMID:16630673 |
|
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
ISO |
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of IL6 protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein] [Zinc co-treated with Aluminum] results in increased expression of IL6 protein; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of IL6 protein |
CTD |
PMID:27368151 PMID:27816692 PMID:29170048 PMID:37415728 |
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Irf7 |
interferon regulatory factor 7 |
decreases expression |
EXP |
Aluminum results in decreased expression of IRF7 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394
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G |
Isg15 |
ISG15 ubiquitin-like modifier |
decreases expression |
EXP |
Aluminum results in decreased expression of ISG15 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 4:156,283,881...156,285,275
Ensembl chr 4:156,283,912...156,285,253
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G |
Jun |
jun proto-oncogene |
multiple interactions |
EXP |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein] |
CTD |
PMID:23690655 |
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NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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G |
Klk1 |
kallikrein 1 |
multiple interactions |
ISO |
Aluminum binds to and results in decreased activity of KLK1 protein |
CTD |
PMID:15558947 |
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NCBI chr 7:43,874,784...43,879,046
Ensembl chr 7:43,874,784...43,879,042
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G |
Litaf |
LPS-induced TN factor |
multiple interactions |
ISO |
[Titanium co-treated with Vanadium co-treated with Aluminum] results in increased expression of LITAF mRNA |
CTD |
PMID:17408380 |
|
NCBI chr16:10,777,137...10,810,985
Ensembl chr16:10,777,139...10,884,021
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G |
Lonrf2 |
LON peptidase N-terminal domain and ring finger 2 |
decreases expression |
ISO |
Aluminum results in decreased expression of LONRF2 mRNA |
CTD |
PMID:19010380 |
|
NCBI chr 1:38,832,750...38,875,768
Ensembl chr 1:38,832,726...38,875,792
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G |
Manf |
mesencephalic astrocyte-derived neurotrophic factor |
decreases expression |
EXP |
Aluminum results in decreased expression of MANF mRNA; Aluminum results in decreased expression of MANF protein |
CTD |
PMID:37544489 |
|
NCBI chr 9:106,765,952...106,769,137
Ensembl chr 9:106,715,511...106,769,178
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
EXP |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MAP1LC3B mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased lipidation of MAP1LC3B protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MAP1LC3B mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased lipidation of MAP1LC3B protein] |
CTD |
PMID:34547296 |
|
NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
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G |
Mapk3 |
mitogen-activated protein kinase 3 |
multiple interactions |
ISO |
[Aluminum co-treated with Iron] results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:16728372 |
|
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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G |
Mapt |
microtubule-associated protein tau |
increases phosphorylation multiple interactions |
ISO |
Aluminum results in increased phosphorylation of MAPT protein [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] |
CTD |
PMID:17662457 PMID:29170048 |
|
NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
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G |
Mir21a |
microRNA 21a |
multiple interactions |
ISO |
[Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR21 mRNA |
CTD |
PMID:27506416 |
|
NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984
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G |
Mir30d |
microRNA 30d |
multiple interactions |
ISO |
[Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR30D mRNA |
CTD |
PMID:27506416 |
|
NCBI chr15:68,213,057...68,213,138
Ensembl chr15:68,213,057...68,213,138
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G |
Mir322 |
microRNA 322 |
multiple interactions |
ISO |
[Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR424 mRNA |
CTD |
PMID:27506416 |
|
NCBI chr X:52,143,132...52,143,226
Ensembl chr X:52,143,132...52,143,226
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G |
Mmp2 |
matrix metallopeptidase 2 |
increases expression |
ISO |
Aluminum results in increased expression of MMP2 protein |
CTD |
PMID:16052892 |
|
NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
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G |
Mmp7 |
matrix metallopeptidase 7 |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MMP7 mRNA |
CTD |
PMID:32437896 |
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NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,587
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression multiple interactions |
ISO |
Aluminum results in increased expression of MMP9 protein [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MMP9 mRNA |
CTD |
PMID:16052892 PMID:32437896 |
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NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
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G |
Mpo |
myeloperoxidase |
increases expression |
ISO |
Aluminum results in increased expression of MPO protein |
CTD |
PMID:17402216 |
|
NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
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G |
Mrpl20 |
mitochondrial ribosomal protein L20 |
decreases expression |
EXP |
Aluminum results in decreased expression of MRPL20 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 4:155,887,335...155,893,288
Ensembl chr 4:155,887,335...155,894,432
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G |
Msmo1 |
methylsterol monoxygenase 1 |
increases expression |
EXP |
Aluminum results in increased expression of MSMO1 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826
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G |
mt-Rnr2 |
16S rRNA, mitochondrial |
increases expression |
EXP |
Aluminum results in increased expression of MT-RNR2 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr MT:1,094...2,675
Ensembl chr MT:1,094...2,675
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G |
Mtr |
5-methyltetrahydrofolate-homocysteine methyltransferase |
multiple interactions |
ISO |
Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Aluminum inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; Aluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form] |
CTD |
PMID:14745455 PMID:26989453 |
|
NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999
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G |
Myc |
myelocytomatosis oncogene |
increases expression |
EXP |
Aluminum results in increased expression of MYC mRNA; Aluminum results in increased expression of MYC protein |
CTD |
PMID:37544489 |
|
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
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G |
Nes |
nestin |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of NES protein; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of NES protein] |
CTD |
PMID:32959702 |
|
NCBI chr 3:87,878,400...87,887,758
Ensembl chr 3:87,878,385...87,887,758
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G |
Nfe2l2 |
nuclear factor, erythroid derived 2, like 2 |
multiple interactions |
ISO |
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFE2L2 protein |
CTD |
PMID:37415728 |
|
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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G |
Nfkb1 |
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
multiple interactions |
ISO |
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFKB1 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFKB1 protein |
CTD |
PMID:37415728 |
|
NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
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G |
Nos2 |
nitric oxide synthase 2, inducible |
multiple interactions |
ISO EXP |
[Aluminum co-treated with Iron] results in increased expression of NOS2 protein [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] |
CTD |
PMID:16728372 PMID:23690655 |
|
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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G |
Nrg1 |
neuregulin 1 |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [NRG1 protein results in increased phosphorylation of ESR1 protein] |
CTD |
PMID:31945389 |
|
NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825 Ensembl chr 8:32,304,579...33,374,825
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G |
Oas1a |
2'-5' oligoadenylate synthetase 1A |
decreases expression |
EXP |
Aluminum results in decreased expression of OAS1A mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 5:121,034,319...121,045,588
Ensembl chr 5:121,034,319...121,045,584
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G |
Oas1g |
2'-5' oligoadenylate synthetase 1G |
decreases expression |
EXP |
Aluminum results in decreased expression of OAS1G mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 5:121,014,205...121,025,676
Ensembl chr 5:121,014,205...121,025,676
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G |
Oasl2 |
2'-5' oligoadenylate synthetase-like 2 |
decreases expression |
EXP |
Aluminum results in decreased expression of OASL2 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 5:115,034,995...115,050,306
Ensembl chr 5:115,034,997...115,050,295
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G |
Ogdh |
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) |
multiple interactions increases activity |
ISO |
Aluminum results in decreased expression of and results in decreased activity of OGDH protein Aluminum results in increased activity of OGDH protein |
CTD |
PMID:10806405 PMID:16906525 |
|
NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642
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G |
Oprd1 |
opioid receptor, delta 1 |
multiple interactions |
ISO |
[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in decreased abundance of Aluminum |
CTD |
PMID:7477890 |
|
NCBI chr 4:131,834,980...131,872,042
Ensembl chr 4:131,838,037...131,871,797
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G |
Parp10 |
poly (ADP-ribose) polymerase family, member 10 |
decreases expression |
EXP |
Aluminum results in decreased expression of PARP10 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr15:76,117,195...76,127,640
Ensembl chr15:76,115,374...76,127,641
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G |
Parp9 |
poly (ADP-ribose) polymerase family, member 9 |
decreases expression |
EXP |
Aluminum results in decreased expression of PARP9 mRNA; Aluminum results in decreased expression of PARP9 protein |
CTD |
PMID:37544489 |
|
NCBI chr16:35,759,360...35,792,975
Ensembl chr16:35,758,840...35,792,975
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1, cytosolic |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of PCK1 protein |
CTD |
PMID:31945389 |
|
NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
[aluminum chloride results in increased abundance of Aluminum] which results in decreased expression of PCNA mRNA |
CTD |
PMID:29635646 |
|
NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
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G |
Pcyt2 |
phosphate cytidylyltransferase 2, ethanolamine |
increases expression |
EXP |
Aluminum results in increased expression of PCYT2 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr11:120,500,888...120,508,784
Ensembl chr11:120,500,913...120,508,762
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G |
Pink1 |
PTEN induced putative kinase 1 |
multiple interactions |
EXP |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 mRNA] |
CTD |
PMID:34547296 |
|
NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618
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G |
Pklr |
pyruvate kinase liver and red blood cell |
increases activity |
ISO |
Aluminum results in increased activity of PKLR protein |
CTD |
PMID:16979867 |
|
NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091
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G |
Plcd1 |
phospholipase C, delta 1 |
increases expression |
ISO |
Aluminum results in increased expression of PLCD1 protein |
CTD |
PMID:10814511 |
|
NCBI chr 9:118,900,595...118,922,570
Ensembl chr 9:118,900,595...118,922,570
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G |
Prkg2 |
protein kinase, cGMP-dependent, type II |
increases expression |
EXP |
Aluminum results in increased expression of PRKG2 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 5:99,077,632...99,185,042
Ensembl chr 5:99,077,632...99,185,210
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G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions |
EXP |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN mRNA] |
CTD |
PMID:34547296 |
|
NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248
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G |
Psmb8 |
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) |
decreases expression |
EXP |
Aluminum results in decreased expression of PSMB8 mRNA; Aluminum results in decreased expression of PSMB8 protein |
CTD |
PMID:37544489 |
|
NCBI chr17:34,417,169...34,420,428
Ensembl chr17:34,416,695...34,420,428
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
increases expression |
EXP |
Aluminum results in increased expression of PTGS1 mRNA; Aluminum results in increased expression of PTGS1 protein |
CTD |
PMID:37544489 |
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NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
EXP |
Aluminum results in increased expression of PTGS2 mRNA; Aluminum results in increased expression of PTGS2 protein [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 protein] |
CTD |
PMID:16928369 PMID:23690655 |
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NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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G |
Pth |
parathyroid hormone |
multiple interactions |
ISO |
[TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein |
CTD |
PMID:10978387 |
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NCBI chr 7:112,984,783...112,987,879
Ensembl chr 7:112,984,787...112,987,777
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G |
Rcvrn |
recoverin |
multiple interactions |
ISO |
[APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA |
CTD |
PMID:21298039 |
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NCBI chr11:67,586,152...67,594,181
Ensembl chr11:67,586,152...67,594,159
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G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
multiple interactions |
EXP |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] |
CTD |
PMID:23690655 |
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NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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G |
Rpl37 |
ribosomal protein L37 |
decreases expression |
ISO |
Aluminum results in decreased expression of RPL37 mRNA; Aluminum results in decreased expression of RPL37 protein |
CTD |
PMID:27329587 |
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NCBI chr15:5,146,127...5,148,626
Ensembl chr15:5,146,127...5,148,622
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G |
Rtp4 |
receptor transporter protein 4 |
decreases expression |
EXP |
Aluminum results in decreased expression of RTP4 mRNA |
CTD |
PMID:37544489 |
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NCBI chr16:23,338,976...23,432,972
Ensembl chr16:23,339,041...23,432,972
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G |
S100b |
S100 protein, beta polypeptide, neural |
increases expression multiple interactions |
ISO |
Aluminum results in increased expression of S100B protein Vitamin E inhibits the reaction [Aluminum results in increased expression of S100B protein] |
CTD |
PMID:16545059 |
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NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993
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G |
Scgb1a1 |
secretoglobin, family 1A, member 1 |
decreases expression |
ISO |
Aluminum results in decreased expression of SCGB1A1 protein |
CTD |
PMID:16052892 PMID:16099050 |
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NCBI chr19:9,061,006...9,065,320
Ensembl chr19:9,061,000...9,065,322
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G |
Shisa5 |
shisa family member 5 |
decreases expression |
EXP |
Aluminum results in decreased expression of SHISA5 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 9:108,867,635...108,886,860
Ensembl chr 9:108,867,633...108,886,845
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G |
Slc2a1 |
solute carrier family 2 (facilitated glucose transporter), member 1 |
increases expression |
ISO |
Aluminum results in increased expression of SLC2A1 protein |
CTD |
PMID:16979867 |
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NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180
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G |
Snai1 |
snail family zinc finger 1 |
multiple interactions |
ISO |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 protein |
CTD |
PMID:32437896 |
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NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734
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G |
Snca |
synuclein, alpha |
affects response to substance multiple interactions |
ISO |
SNCA protein affects the susceptibility to Aluminum [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNCA protein; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNCA protein] |
CTD |
PMID:23106139 PMID:32959702 |
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NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
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G |
Sod2 |
superoxide dismutase 2, mitochondrial |
decreases activity |
ISO |
Aluminum results in decreased activity of SOD2 protein |
CTD |
PMID:19010380 |
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NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
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G |
Spp1 |
secreted phosphoprotein 1 |
increases expression |
EXP |
Aluminum results in increased expression of SPP1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
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G |
Sprr1a |
small proline-rich protein 1A |
increases expression |
EXP |
Aluminum results in increased expression of SPRR1A mRNA |
CTD |
PMID:37544489 |
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NCBI chr 3:92,391,261...92,393,188
Ensembl chr 3:92,391,259...92,393,202
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
EXP |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 mRNA] |
CTD |
PMID:34547296 |
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NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
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G |
Stat1 |
signal transducer and activator of transcription 1 |
decreases expression |
EXP |
Aluminum results in decreased expression of STAT1 mRNA; Aluminum results in decreased expression of STAT1 protein |
CTD |
PMID:37544489 |
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NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
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G |
Tfrc |
transferrin receptor |
decreases expression affects uptake |
ISO |
Aluminum results in decreased expression of TFRC mRNA TFRC protein affects the uptake of Aluminum |
CTD |
PMID:9630424 PMID:11068183 |
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NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of TGFB1 mRNA |
CTD |
PMID:32437896 |
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NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
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G |
Tnf |
tumor necrosis factor |
increases expression multiple interactions |
ISO EXP |
Aluminum results in increased expression of TNF protein [Titanium co-treated with Vanadium co-treated with Aluminum] results in increased expression of TNF mRNA [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of TNF protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of TNF protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Aluminum results in increased expression of TNF protein] [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA] |
CTD |
PMID:16545059 PMID:17408380 PMID:23690655 PMID:27368151 PMID:29170048 PMID:32959702 PMID:37415728 More...
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
Trf |
transferrin |
multiple interactions affects binding increases uptake |
ISO EXP |
[Aluminum binds to TF protein] which results in decreased uptake of Iron; [Aluminum binds to TF protein] which results in decreased uptake of Manganese; [Aluminum binds to TF protein] which results in increased uptake of Aluminum; [TF protein binds to Aluminum] affects the activity of [TF protein binds to Iron]; [TF protein binds to Aluminum] which results in increased uptake of Aluminum; [TF protein binds to Aluminum] which results in increased uptake of Iron; [TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein; TF protein binds to [Aluminum co-treated with Iron]; TF protein binds to and results in increased uptake of Aluminum TRF protein binds to Aluminum Aluminum binds to TF protein; TF protein binds to Aluminum TF protein results in increased uptake of Aluminum |
CTD |
PMID:1375080 PMID:2039817 PMID:2308257 PMID:8782865 PMID:10978387 PMID:11193083 PMID:12627980 PMID:15149824 PMID:19859668 PMID:22873711 More...
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NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
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G |
Tubb3 |
tubulin, beta 3 class III |
multiple interactions |
EXP |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of TUBB3 protein |
CTD |
PMID:31363819 |
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NCBI chr 8:124,138,292...124,148,754
Ensembl chr 8:124,138,163...124,148,754
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G |
Txn2 |
thioredoxin 2 |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of TXN2 protein |
CTD |
PMID:31945389 |
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NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206
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G |
Uba52 |
ubiquitin A-52 residue ribosomal protein fusion product 1 |
decreases expression |
ISO |
Aluminum results in decreased expression of UBA52 mRNA; Aluminum results in decreased expression of UBA52 protein |
CTD |
PMID:27329587 |
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NCBI chr 8:70,960,913...70,963,067
Ensembl chr 8:70,960,913...70,963,451
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G |
Ube2l6 |
ubiquitin-conjugating enzyme E2L 6 |
decreases expression |
EXP |
Aluminum results in decreased expression of UBE2L6 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 2:84,629,172...84,640,347
Ensembl chr 2:84,629,172...84,640,679
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G |
Usp18 |
ubiquitin specific peptidase 18 |
decreases expression |
EXP |
Aluminum results in decreased expression of USP18 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VCAM1 protein; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VCAM1 protein] |
CTD |
PMID:32959702 |
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NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VEGFA protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of and results in increased secretion of VEGFA protein; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased secretion of VEGFA protein [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of VEGFA protein; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of VEGFA protein] |
CTD |
PMID:32437896 PMID:32959702 |
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NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
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G |
Vim |
vimentin |
multiple interactions increases expression |
ISO EXP |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM protein Aluminum results in increased expression of VIM mRNA |
CTD |
PMID:32437896 PMID:37544489 |
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NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
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G |
Xaf1 |
XIAP associated factor 1 |
decreases expression |
EXP |
Aluminum results in decreased expression of XAF1 mRNA; Aluminum results in decreased expression of XAF1 protein |
CTD |
PMID:37544489 |
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NCBI chr11:72,192,229...72,204,560
Ensembl chr11:72,192,455...72,204,559
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G |
Xbp1 |
X-box binding protein 1 |
decreases expression |
EXP |
Aluminum results in decreased expression of XBP1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
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G |
Xdh |
xanthine dehydrogenase |
increases activity |
ISO |
Aluminum results in increased activity of XDH protein |
CTD |
PMID:11787993 |
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NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191
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G |
Zbp1 |
Z-DNA binding protein 1 |
decreases expression |
EXP |
Aluminum results in decreased expression of ZBP1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 2:173,048,405...173,060,715
Ensembl chr 2:173,048,405...173,060,716
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