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G |
HMBS |
hydroxymethylbilane synthase |
decreases activity |
ISO |
Aluminium ion decreases activity of purified Hmbs protein |
RGD |
PMID:6732900 |
RGD:25394584 |
NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834
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G |
ACE |
angiotensin I converting enzyme |
decreases activity |
ISO |
Aluminum results in decreased activity of ACE protein |
CTD |
PMID:12008977 |
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NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
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G |
ACHE |
acetylcholinesterase (Yt blood group) |
multiple interactions decreases activity |
ISO |
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium co-treated with Zinc] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased activity of ACHE protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA; Aluminum promotes the reaction [Lead results in decreased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA]; Copper inhibits the reaction [Aluminum results in decreased activity of ACHE protein]; Plant Extracts inhibits the reaction [Aluminum results in decreased activity of ACHE protein] |
CTD |
PMID:15266904 PMID:23354609 PMID:24486960 PMID:29170048 PMID:37415728 |
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NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
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G |
ACLY |
ATP citrate lyase |
multiple interactions |
EXP |
Aluminum results in increased expression of and results in increased activity of ACLY protein |
CTD |
PMID:17762189 |
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NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542
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G |
ACO1 |
aconitase 1 |
decreases activity |
ISO |
Aluminum results in decreased activity of ACO1 protein |
CTD |
PMID:10806405 |
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NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769
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G |
ACO2 |
aconitase 2 |
decreases activity multiple interactions |
ISO EXP |
Aluminum results in decreased activity of ACO2 protein Aluminum promotes the reaction [Nitroprusside results in decreased activity of ACO2 protein] Aluminum results in decreased expression of and results in decreased activity of ACO2 protein |
CTD |
PMID:12470706 PMID:16906525 PMID:19010380 |
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NCBI chr22:41,469,117...41,528,974
Ensembl chr22:41,447,830...41,529,273
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G |
ALB |
albumin |
affects binding |
EXP |
ALB protein binds to Aluminum |
CTD |
PMID:14507469 |
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NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
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G |
ALOX5 |
arachidonate 5-lipoxygenase |
multiple interactions increases expression |
ISO |
caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein] Aluminum results in increased expression of ALOX5 mRNA; Aluminum results in increased expression of ALOX5 protein |
CTD |
PMID:27368151 |
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NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
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G |
ALPL |
alkaline phosphatase, biomineralization associated |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of ALPL mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of ALPL mRNA] |
CTD |
PMID:34547296 |
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NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410
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G |
APOB |
apolipoprotein B |
increases expression |
EXP |
Aluminum results in increased expression of APOB protein |
CTD |
PMID:17762189 |
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NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
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G |
APP |
amyloid beta precursor protein |
affects binding multiple interactions increases expression increases cleavage |
EXP ISO |
APP protein binds to Aluminum [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] [APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA Aluminum results in increased expression of APP mRNA APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]; meloxicam inhibits the reaction [Aluminum results in increased expression of APP protein]; Vitamin E inhibits the reaction [Aluminum results in increased cleavage of APP protein] |
CTD |
PMID:12039845 PMID:16308480 PMID:16724269 PMID:16928369 PMID:16942756 PMID:21298039 PMID:29170048 More...
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NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
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G |
ATXN3 |
ataxin 3 |
affects folding multiple interactions |
ISO EXP |
Aluminum affects the folding of ATXN3 protein polymorphism Aluminum promotes the reaction [ATXN3 protein polymorphism binds to ATXN3 protein polymorphism] |
CTD |
PMID:17300980 |
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NCBI chr14:92,044,775...92,106,582
Ensembl chr14:92,044,496...92,106,621
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G |
BAX |
BCL2 associated X, apoptosis regulator |
affects response to substance multiple interactions |
ISO EXP |
BAX protein affects the susceptibility to Aluminum [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX protein] [aluminum chlorhydrate results in increased abundance of Aluminum] which affects the expression of BAX protein |
CTD |
PMID:20385067 PMID:31945389 PMID:34547296 |
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NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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G |
BBOX1 |
gamma-butyrobetaine hydroxylase 1 |
multiple interactions decreases expression |
EXP |
Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Ketoglutaric Acids inhibits the reaction [Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]] Aluminum results in decreased expression of BBOX1 protein |
CTD |
PMID:21439360 |
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NCBI chr11:27,040,815...27,127,809
Ensembl chr11:27,040,725...27,127,809
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G |
BCL2 |
BCL2 apoptosis regulator |
multiple interactions |
EXP ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein; Fulvestrant inhibits the reaction [[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein] [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein] |
CTD |
PMID:31945389 PMID:34547296 |
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
BCL2L1 |
BCL2 like 1 |
multiple interactions |
EXP |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2L1 protein |
CTD |
PMID:31945389 |
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NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
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G |
BGLAP |
bone gamma-carboxyglutamate protein |
multiple interactions decreases secretion |
ISO |
Aluminum inhibits the reaction [Calcitriol results in increased secretion of BGLAP protein]; Calcitriol inhibits the reaction [Aluminum results in decreased secretion of BGLAP protein] [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP protein] |
CTD |
PMID:9626627 PMID:34547296 |
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NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
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G |
BGN |
biglycan |
increases expression |
ISO |
Aluminum results in increased expression of BGN mRNA |
CTD |
PMID:37544489 |
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NCBI chr X:153,494,980...153,509,546
Ensembl chr X:153,494,980...153,509,546
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G |
CALD1 |
caldesmon 1 |
increases expression |
ISO |
Aluminum results in increased expression of CALD1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 7:134,745,467...134,970,729
Ensembl chr 7:134,744,252...134,970,729
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G |
CASP12 |
caspase 12 (gene/pseudogene) |
multiple interactions |
ISO |
[aluminum chloride results in increased abundance of Aluminum] which results in increased expression of CASP12 mRNA |
CTD |
PMID:29635646 |
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NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670
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G |
CASP3 |
caspase 3 |
increases expression multiple interactions |
ISO |
Aluminum results in increased expression of CASP3 [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of CASP3 protein [Aluminum Chloride results in increased abundance of Aluminum] which results in increased cleavage of CASP3 protein; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CASP3 mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CASP3 mRNA] |
CTD |
PMID:21972528 PMID:34547296 PMID:37415728 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CASP9 |
caspase 9 |
multiple interactions |
EXP |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of CASP9 protein; Fulvestrant inhibits the reaction [[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of CASP9 protein] |
CTD |
PMID:31945389 |
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NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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G |
CASR |
calcium sensing receptor |
multiple interactions |
ISO |
[Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; [Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates; Aluminum binds to and results in increased activity of CASR protein |
CTD |
PMID:10231437 |
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NCBI chr 3:122,183,668...122,291,629
Ensembl chr 3:122,183,668...122,291,629
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G |
CAT |
catalase |
decreases activity multiple interactions |
EXP ISO |
Aluminum results in decreased activity of CAT protein [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased activity of CAT protein] [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased activity of CAT protein; CAT protein results in decreased susceptibility to [Tyramine co-treated with Aluminum]; Plant Extracts inhibits the reaction [Aluminum results in decreased activity of CAT protein] Vitamin E inhibits the reaction [Aluminum results in decreased activity of CAT protein] |
CTD |
PMID:15526171 PMID:17709913 PMID:24486960 PMID:34547296 PMID:37415728 |
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NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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G |
CCL7 |
C-C motif chemokine ligand 7 |
decreases expression |
ISO |
Aluminum results in decreased expression of CCL7 mRNA |
CTD |
PMID:37544489 |
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NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242
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G |
CDH1 |
cadherin 1 |
multiple interactions |
EXP |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 protein |
CTD |
PMID:32437896 |
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NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
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G |
CHAT |
choline O-acetyltransferase |
decreases expression decreases activity multiple interactions |
ISO |
Aluminum results in decreased expression of CHAT protein Aluminum results in decreased activity of CHAT protein APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]; meloxicam inhibits the reaction [Aluminum results in decreased expression of CHAT protein] |
CTD |
PMID:16724269 PMID:16928369 |
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NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
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G |
COL1A1 |
collagen type I alpha 1 chain |
multiple interactions decreases expression |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of COL1A1 mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of COL1A1 mRNA] Aluminum results in decreased expression of COL1A1 mRNA |
CTD |
PMID:34547296 PMID:37544489 |
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NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
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G |
CRP |
C-reactive protein |
multiple interactions |
EXP |
[Zinc co-treated with Aluminum] results in increased expression of CRP protein; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of CRP protein |
CTD |
PMID:27816692 |
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NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
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G |
CX3CL1 |
C-X3-C motif chemokine ligand 1 |
increases expression |
ISO |
Aluminum results in increased expression of CX3CL1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044
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G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
increases expression |
EXP |
Aluminum analog results in increased expression of CXCL8 mRNA |
CTD |
PMID:23724284 |
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NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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G |
CYCS |
cytochrome c, somatic |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CYCS mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CYCS mRNA] |
CTD |
PMID:34547296 |
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NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
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G |
DAXX |
death domain associated protein |
increases expression |
EXP |
Aluminum results in increased expression of DAXX mRNA |
CTD |
PMID:16308480 |
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NCBI chr 6:33,318,558...33,322,959
Ensembl chr 6:33,318,558...33,323,016
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G |
DRD1 |
dopamine receptor D1 |
multiple interactions |
ISO |
Aluminum inhibits the reaction [SCH 23390 binds to DRD1 protein] |
CTD |
PMID:9109525 |
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NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182
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G |
DRD2 |
dopamine receptor D2 |
multiple interactions |
ISO |
Aluminum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein] |
CTD |
PMID:9109525 |
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NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
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G |
ECM1 |
extracellular matrix protein 1 |
increases expression |
ISO |
Aluminum results in increased expression of ECM1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 1:150,508,109...150,513,789
Ensembl chr 1:150,508,062...150,513,789
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G |
EGLN3 |
egl-9 family hypoxia inducible factor 3 |
increases expression |
ISO |
Aluminum results in increased expression of EGLN3 mRNA; Aluminum results in increased expression of EGLN3 protein |
CTD |
PMID:37544489 |
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NCBI chr14:33,924,227...33,951,074
Ensembl chr14:33,924,227...34,462,774
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G |
ENO2 |
enolase 2 |
decreases activity |
EXP |
Aluminum results in decreased activity of ENO2 protein |
CTD |
PMID:11860913 |
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NCBI chr12:6,914,580...6,923,697
Ensembl chr12:6,913,745...6,923,698
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G |
EPOR |
erythropoietin receptor |
affects expression |
EXP |
Aluminum affects the expression of EPOR protein |
CTD |
PMID:15777837 |
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NCBI chr19:11,377,207...11,384,314
Ensembl chr19:11,377,207...11,384,342
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G |
ESR1 |
estrogen receptor 1 |
multiple interactions |
EXP |
[aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; [aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [NRG1 protein results in increased phosphorylation of ESR1 protein]; [aluminum chlorhydrate results in increased abundance of Aluminum] which results in increased expression of ESR1 protein; [Estradiol co-treated with [aluminum chlorhydrate results in increased abundance of Aluminum]] results in increased expression of ESR1 protein |
CTD |
PMID:31945389 |
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NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
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G |
ESR2 |
estrogen receptor 2 |
multiple interactions |
EXP |
[[aluminum chlorhydrate results in increased abundance of Aluminum] co-treated with [Tretinoin co-treated with Estradiol]] affects the localization of ESR2 protein; [[aluminum chlorhydrate results in increased abundance of Aluminum] which co-treated with Tretinoin] results in decreased expression of and affects the localization of ESR2 protein; [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of and affects the localization of ESR2 protein; [Estradiol co-treated with [aluminum chlorhydrate results in increased abundance of Aluminum]] results in decreased expression of ESR2 protein |
CTD |
PMID:31945389 |
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NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112
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G |
F8 |
coagulation factor VIII |
affects folding multiple interactions |
EXP |
Aluminum affects the folding of F8 protein [Aluminum promotes the reaction [F8 protein binds to F8 protein]] which results in decreased activity of F8 protein |
CTD |
PMID:15349964 |
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NCBI chr X:154,835,792...155,022,723
Ensembl chr X:154,835,788...155,026,940
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G |
FDFT1 |
farnesyl-diphosphate farnesyltransferase 1 |
increases expression |
ISO |
Aluminum results in increased expression of FDFT1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 8:11,795,582...11,839,298
Ensembl chr 8:11,795,573...11,839,395
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G |
FH |
fumarate hydratase |
multiple interactions |
EXP |
Aluminum results in decreased expression of and results in decreased activity of FH protein |
CTD |
PMID:16906525 |
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NCBI chr 1:241,497,603...241,519,755
Ensembl chr 1:241,497,511...241,519,799
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G |
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein] |
CTD |
PMID:23690655 |
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NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190
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G |
FOSL1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
ISO |
Aluminum results in increased expression of FOSL1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573
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G |
G6PD |
glucose-6-phosphate dehydrogenase |
increases activity |
EXP ISO |
Aluminum results in increased activity of G6PD protein |
CTD |
PMID:16572710 PMID:16979867 |
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NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572
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G |
GBP4 |
guanylate binding protein 4 |
decreases expression |
ISO |
Aluminum results in decreased expression of GBP3 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 1:89,181,144...89,198,942
Ensembl chr 1:89,181,144...89,198,942
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G |
GCHFR |
GTP cyclohydrolase I feedback regulator |
increases expression |
ISO |
Aluminum results in increased expression of GCHFR mRNA |
CTD |
PMID:37544489 |
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NCBI chr15:40,764,068...40,767,708
Ensembl chr15:40,764,068...40,767,708
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G |
GFAP |
glial fibrillary acidic protein |
increases expression multiple interactions |
ISO |
Aluminum results in increased expression of GFAP protein [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of GFAP protein Vitamin E inhibits the reaction [Aluminum results in increased expression of GFAP protein] |
CTD |
PMID:16545059 PMID:31363819 |
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NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
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G |
GNAI1 |
G protein subunit alpha i1 |
decreases expression |
ISO |
Aluminum results in decreased expression of GNAI1 protein |
CTD |
PMID:9626627 |
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NCBI chr 7:80,134,831...80,226,181
Ensembl chr 7:79,768,028...80,226,181
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G |
GNAI2 |
G protein subunit alpha i2 |
decreases expression |
ISO |
Aluminum results in decreased expression of GNAI2 protein |
CTD |
PMID:9626627 |
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NCBI chr 3:50,227,068...50,263,358
Ensembl chr 3:50,226,292...50,259,362
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G |
GNAQ |
G protein subunit alpha q |
increases response to substance |
ISO |
GNAQ protein results in increased susceptibility to Aluminum |
CTD |
PMID:15068510 |
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NCBI chr 9:77,716,097...78,031,811
Ensembl chr 9:77,716,097...78,031,811
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G |
GPD1 |
glycerol-3-phosphate dehydrogenase 1 |
multiple interactions |
EXP |
Aluminum results in increased expression of and results in increased activity of GPD1 protein |
CTD |
PMID:17762189 |
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NCBI chr12:50,104,008...50,111,313
Ensembl chr12:50,103,982...50,111,313
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G |
GPX1 |
glutathione peroxidase 1 |
decreases activity multiple interactions |
EXP |
Aluminum results in decreased activity of GPX1 protein Vitamin E inhibits the reaction [Aluminum results in decreased activity of GPX1 protein] |
CTD |
PMID:17709913 |
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NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
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G |
GSR |
glutathione-disulfide reductase |
decreases expression multiple interactions |
ISO |
Aluminum results in decreased expression of GSR protein Plant Extracts inhibits the reaction [Aluminum results in decreased expression of GSR protein] |
CTD |
PMID:24486960 |
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NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
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G |
HIF1A |
hypoxia inducible factor 1 subunit alpha |
increases localization |
EXP |
Aluminum results in increased localization of HIF1A protein |
CTD |
PMID:16979867 |
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NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
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G |
HK1 |
hexokinase 1 |
multiple interactions decreases activity |
ISO |
Meclofenoxate inhibits the reaction [Aluminum results in decreased activity of HK1 protein] |
CTD |
PMID:16969689 |
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NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884
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G |
HMGA1 |
high mobility group AT-hook 1 |
increases expression |
ISO |
Aluminum results in increased expression of HMGA1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 6:34,236,873...34,246,231
Ensembl chr 6:34,236,873...34,246,231
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G |
IDH1 |
isocitrate dehydrogenase (NADP(+)) 1 |
decreases activity |
ISO |
Aluminum results in decreased activity of IDH1 protein |
CTD |
PMID:15486972 |
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NCBI chr 2:208,236,227...208,255,071
Ensembl chr 2:208,236,229...208,266,074
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G |
IDH2 |
isocitrate dehydrogenase (NADP(+)) 2 |
decreases activity |
ISO |
Aluminum results in decreased activity of IDH2 protein |
CTD |
PMID:15486972 |
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NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477
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G |
IFI27L2 |
interferon alpha inducible protein 27 like 2 |
decreases expression |
ISO |
Aluminum results in decreased expression of IFI27L2A mRNA |
CTD |
PMID:37544489 |
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NCBI chr14:94,127,781...94,129,604
Ensembl chr14:94,127,779...94,130,253
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G |
IFI35 |
interferon induced protein 35 |
decreases expression |
ISO |
Aluminum results in decreased expression of IFI35 mRNA |
CTD |
PMID:37544489 |
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NCBI chr17:43,006,784...43,014,456
Ensembl chr17:43,006,740...43,014,456
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G |
IFIT1B |
interferon induced protein with tetratricopeptide repeats 1B |
decreases expression |
ISO |
Aluminum results in decreased expression of IFIT1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr10:89,378,056...89,385,205
Ensembl chr10:89,378,056...89,385,205
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G |
IFIT3 |
interferon induced protein with tetratricopeptide repeats 3 |
decreases expression |
ISO |
Aluminum results in decreased expression of IFIT3 mRNA |
CTD |
PMID:37544489 |
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NCBI chr10:89,327,997...89,340,968
Ensembl chr10:89,327,307...89,377,473
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G |
IFNB1 |
interferon beta 1 |
multiple interactions |
ISO |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IFNB1 mRNA] |
CTD |
PMID:23690655 |
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NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942
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G |
IGF1 |
insulin like growth factor 1 |
multiple interactions |
EXP |
Aluminum inhibits the reaction [IGF1 protein results in increased activity of MTR protein] |
CTD |
PMID:14745455 |
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NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
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G |
IL12B |
interleukin 12B |
multiple interactions |
ISO |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B mRNA] |
CTD |
PMID:23690655 |
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NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863
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G |
IL1B |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]; Vitamin E inhibits the reaction [Aluminum results in increased expression of IL1B protein] |
CTD |
PMID:16545059 PMID:27368151 PMID:29170048 |
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NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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G |
IL4 |
interleukin 4 |
increases expression |
ISO |
Aluminum results in increased expression of IL4 mRNA |
CTD |
PMID:16630673 |
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NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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G |
IL6 |
interleukin 6 |
multiple interactions increases expression |
EXP ISO |
[Zinc co-treated with Aluminum] results in increased expression of IL6 protein; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of IL6 protein [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of IL6 protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein] |
CTD |
PMID:27368151 PMID:27816692 PMID:29170048 PMID:37415728 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
IRF7 |
interferon regulatory factor 7 |
decreases expression |
ISO |
Aluminum results in decreased expression of IRF7 mRNA |
CTD |
PMID:37544489 |
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NCBI chr11:612,555...615,950
Ensembl chr11:612,553...615,983
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G |
ISG15 |
ISG15 ubiquitin like modifier |
decreases expression |
ISO |
Aluminum results in decreased expression of ISG15 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 1:1,013,497...1,014,540
Ensembl chr 1:1,001,138...1,014,540
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein] |
CTD |
PMID:23690655 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
KLK1 |
kallikrein 1 |
multiple interactions |
EXP |
Aluminum binds to and results in decreased activity of KLK1 protein |
CTD |
PMID:15558947 |
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NCBI chr19:50,819,146...50,823,787
Ensembl chr19:50,819,146...50,823,787
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G |
LITAF |
lipopolysaccharide induced TNF factor |
multiple interactions |
EXP |
[Titanium co-treated with Vanadium co-treated with Aluminum] results in increased expression of LITAF mRNA |
CTD |
PMID:17408380 |
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NCBI chr16:11,547,722...11,640,317
Ensembl chr16:11,546,875...11,636,381
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G |
LONRF2 |
LON peptidase N-terminal domain and ring finger 2 |
decreases expression |
ISO |
Aluminum results in decreased expression of LONRF2 mRNA |
CTD |
PMID:19010380 |
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NCBI chr 2:100,271,875...100,322,501
Ensembl chr 2:100,271,875...100,322,501
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G |
MANF |
mesencephalic astrocyte derived neurotrophic factor |
decreases expression |
ISO |
Aluminum results in decreased expression of MANF mRNA; Aluminum results in decreased expression of MANF protein |
CTD |
PMID:37544489 |
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NCBI chr 3:51,385,291...51,389,397
Ensembl chr 3:51,385,291...51,389,397
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G |
MAP1LC3B |
microtubule associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MAP1LC3B mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased lipidation of MAP1LC3B protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MAP1LC3B mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased lipidation of MAP1LC3B protein] |
CTD |
PMID:34547296 |
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NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions |
ISO |
[Aluminum co-treated with Iron] results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:16728372 |
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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G |
MAPT |
microtubule associated protein tau |
increases phosphorylation multiple interactions |
ISO |
Aluminum results in increased phosphorylation of MAPT protein [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] |
CTD |
PMID:17662457 PMID:29170048 |
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NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
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G |
MIR21 |
microRNA 21 |
multiple interactions |
EXP |
[Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR21 mRNA |
CTD |
PMID:27506416 |
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NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
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G |
MIR30D |
microRNA 30d |
multiple interactions |
EXP |
[Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR30D mRNA |
CTD |
PMID:27506416 |
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NCBI chr 8:134,804,876...134,804,945
Ensembl chr 8:134,804,876...134,804,945
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G |
MIR424 |
microRNA 424 |
multiple interactions |
EXP |
[Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR424 mRNA |
CTD |
PMID:27506416 |
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NCBI chr X:134,546,614...134,546,711
Ensembl chr X:134,546,614...134,546,711
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G |
MIR4516 |
microRNA 4516 |
multiple interactions |
EXP |
[Air Pollutants results in increased abundance of Aluminum] which results in increased expression of MIR4516 mRNA |
CTD |
PMID:27329587 |
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NCBI chr16:2,133,119...2,133,204
Ensembl chr16:2,133,119...2,133,204
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G |
MMP2 |
matrix metallopeptidase 2 |
increases expression |
ISO |
Aluminum results in increased expression of MMP2 protein |
CTD |
PMID:16052892 |
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NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
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G |
MMP7 |
matrix metallopeptidase 7 |
multiple interactions |
EXP |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MMP7 mRNA |
CTD |
PMID:32437896 |
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NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750
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G |
MMP9 |
matrix metallopeptidase 9 |
increases expression multiple interactions |
ISO EXP |
Aluminum results in increased expression of MMP9 protein [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MMP9 mRNA |
CTD |
PMID:16052892 PMID:32437896 |
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NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
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G |
MPO |
myeloperoxidase |
increases expression |
EXP |
Aluminum results in increased expression of MPO protein |
CTD |
PMID:17402216 |
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NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
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G |
MRPL20 |
mitochondrial ribosomal protein L20 |
decreases expression |
ISO |
Aluminum results in decreased expression of MRPL20 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 1:1,401,909...1,407,293
Ensembl chr 1:1,401,909...1,407,293
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G |
MSMO1 |
methylsterol monooxygenase 1 |
increases expression |
ISO |
Aluminum results in increased expression of MSMO1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164
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G |
MT-RNR2 |
mitochondrially encoded 16S rRNA |
increases expression |
ISO |
Aluminum results in increased expression of MT-RNR2 mRNA |
CTD |
PMID:37544489 |
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NCBI chr MT:1,671...3,229
Ensembl chr MT:1,671...3,229
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G |
MTR |
5-methyltetrahydrofolate-homocysteine methyltransferase |
multiple interactions |
EXP |
Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Aluminum inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; Aluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form] |
CTD |
PMID:14745455 PMID:26989453 |
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NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278
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G |
MYC |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
Aluminum results in increased expression of MYC mRNA; Aluminum results in increased expression of MYC protein |
CTD |
PMID:37544489 |
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NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
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G |
NES |
nestin |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of NES protein; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of NES protein] |
CTD |
PMID:32959702 |
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NCBI chr 1:156,668,763...156,677,407
Ensembl chr 1:156,668,763...156,677,407
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G |
NFE2L2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFE2L2 protein |
CTD |
PMID:37415728 |
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NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
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G |
NFKB1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFKB1 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFKB1 protein |
CTD |
PMID:37415728 |
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NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
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G |
NOS2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
[Aluminum co-treated with Iron] results in increased expression of NOS2 protein [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] |
CTD |
PMID:16728372 PMID:23690655 |
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NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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G |
NRG1 |
neuregulin 1 |
multiple interactions |
EXP |
[aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [NRG1 protein results in increased phosphorylation of ESR1 protein] |
CTD |
PMID:31945389 |
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NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666
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G |
OAS1 |
2'-5'-oligoadenylate synthetase 1 |
decreases expression |
ISO |
Aluminum results in decreased expression of OAS1G mRNA |
CTD |
PMID:37544489 |
|
NCBI chr12:112,906,962...112,933,219
Ensembl chr12:112,905,856...112,933,219
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G |
OASL2P |
2'-5' oligoadenylate synthetase like 2, pseudogene |
decreases expression |
ISO |
Aluminum results in decreased expression of OASL2 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr12:121,053,732...121,059,670
Ensembl chr12:121,053,732...121,059,670
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G |
OGDH |
oxoglutarate dehydrogenase |
multiple interactions increases activity |
EXP ISO |
Aluminum results in decreased expression of and results in decreased activity of OGDH protein Aluminum results in increased activity of OGDH protein |
CTD |
PMID:10806405 PMID:16906525 |
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NCBI chr 7:44,606,627...44,709,066
Ensembl chr 7:44,606,572...44,709,066
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G |
OPRD1 |
opioid receptor delta 1 |
multiple interactions |
ISO |
[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in decreased abundance of Aluminum |
CTD |
PMID:7477890 |
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NCBI chr 1:28,812,170...28,871,267
Ensembl chr 1:28,812,170...28,871,267
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G |
OR2T34 |
olfactory receptor family 2 subfamily T member 34 |
decreases expression |
ISO |
Aluminum results in decreased expression of IFIT3B mRNA |
CTD |
PMID:37544489 |
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NCBI chr 1:248,573,801...248,574,757
Ensembl chr 1:248,573,801...248,574,757
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G |
PARP10 |
poly(ADP-ribose) polymerase family member 10 |
decreases expression |
ISO |
Aluminum results in decreased expression of PARP10 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 8:143,977,158...144,012,764
Ensembl chr 8:143,977,153...144,012,772
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G |
PARP9 |
poly(ADP-ribose) polymerase family member 9 |
decreases expression |
ISO |
Aluminum results in decreased expression of PARP9 mRNA; Aluminum results in decreased expression of PARP9 protein |
CTD |
PMID:37544489 |
|
NCBI chr 3:122,527,924...122,564,784
Ensembl chr 3:122,527,924...122,564,577
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G |
PCK1 |
phosphoenolpyruvate carboxykinase 1 |
multiple interactions |
EXP |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of PCK1 protein |
CTD |
PMID:31945389 |
|
NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
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G |
PCNA |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
[aluminum chloride results in increased abundance of Aluminum] which results in decreased expression of PCNA mRNA |
CTD |
PMID:29635646 |
|
NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
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G |
PCYT2 |
phosphate cytidylyltransferase 2, ethanolamine |
increases expression |
ISO |
Aluminum results in increased expression of PCYT2 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr17:81,900,958...81,911,399
Ensembl chr17:81,900,958...81,911,432
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G |
PINK1 |
PTEN induced kinase 1 |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 mRNA] |
CTD |
PMID:34547296 |
|
NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
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G |
PKLR |
pyruvate kinase L/R |
increases activity |
EXP |
Aluminum results in increased activity of PKLR protein |
CTD |
PMID:16979867 |
|
NCBI chr 1:155,289,293...155,308,654
Ensembl chr 1:155,289,293...155,301,438
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G |
PLCD1 |
phospholipase C delta 1 |
increases expression |
ISO |
Aluminum results in increased expression of PLCD1 protein |
CTD |
PMID:10814511 |
|
NCBI chr 3:38,007,496...38,029,642
Ensembl chr 3:38,007,496...38,029,642
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G |
PRKG2 |
protein kinase cGMP-dependent 2 |
increases expression |
ISO |
Aluminum results in increased expression of PRKG2 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 4:81,087,370...81,217,836
Ensembl chr 4:81,087,370...81,215,222
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G |
PRKN |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN mRNA] |
CTD |
PMID:34547296 |
|
NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775
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G |
PSMB8 |
proteasome 20S subunit beta 8 |
decreases expression |
ISO |
Aluminum results in decreased expression of PSMB8 mRNA; Aluminum results in decreased expression of PSMB8 protein |
CTD |
PMID:37544489 |
|
NCBI chr 6:32,840,717...32,844,679
Ensembl chr 6:32,840,717...32,844,679
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
increases expression |
ISO |
Aluminum results in increased expression of PTGS1 mRNA; Aluminum results in increased expression of PTGS1 protein |
CTD |
PMID:37544489 |
|
NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
ISO |
Aluminum results in increased expression of PTGS2 mRNA; Aluminum results in increased expression of PTGS2 protein [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 mRNA]; Meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 protein] |
CTD |
PMID:16928369 PMID:23690655 |
|
NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
PTH |
parathyroid hormone |
multiple interactions |
EXP |
[TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein |
CTD |
PMID:10978387 |
|
NCBI chr11:13,492,054...13,496,181
Ensembl chr11:13,492,054...13,496,181
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G |
RCVRN |
recoverin |
multiple interactions |
EXP |
[APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA |
CTD |
PMID:21298039 |
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NCBI chr17:9,896,320...9,905,271
Ensembl chr17:9,896,320...9,905,271
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G |
RELA |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] |
CTD |
PMID:23690655 |
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NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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G |
RPL37 |
ribosomal protein L37 |
decreases expression |
EXP |
Aluminum results in decreased expression of RPL37 mRNA; Aluminum results in decreased expression of RPL37 protein |
CTD |
PMID:27329587 |
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NCBI chr 5:40,825,262...40,835,222
Ensembl chr 5:40,825,262...40,835,222
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G |
RTP4 |
receptor transporter protein 4 |
decreases expression |
ISO |
Aluminum results in decreased expression of RTP4 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 3:187,368,385...187,372,076
Ensembl chr 3:187,368,385...187,372,076
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G |
S100B |
S100 calcium binding protein B |
increases expression multiple interactions |
ISO |
Aluminum results in increased expression of S100B protein Vitamin E inhibits the reaction [Aluminum results in increased expression of S100B protein] |
CTD |
PMID:16545059 |
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NCBI chr21:46,598,604...46,605,082
Ensembl chr21:46,598,604...46,605,208
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G |
SCGB1A1 |
secretoglobin family 1A member 1 |
decreases expression |
ISO EXP |
Aluminum results in decreased expression of SCGB1A1 protein |
CTD |
PMID:16052892 PMID:16099050 |
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NCBI chr11:62,419,033...62,423,195
Ensembl chr11:62,405,103...62,423,195
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G |
SHISA5 |
shisa family member 5 |
decreases expression |
ISO |
Aluminum results in decreased expression of SHISA5 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 3:48,467,876...48,504,810
Ensembl chr 3:48,467,798...48,504,826
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G |
SLC2A1 |
solute carrier family 2 member 1 |
increases expression |
EXP |
Aluminum results in increased expression of SLC2A1 protein |
CTD |
PMID:16979867 |
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NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
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G |
SNAI1 |
snail family transcriptional repressor 1 |
multiple interactions |
EXP |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 protein |
CTD |
PMID:32437896 |
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NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
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G |
SNCA |
synuclein alpha |
affects response to substance multiple interactions |
EXP ISO |
SNCA protein affects the susceptibility to Aluminum [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNCA protein; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNCA protein] |
CTD |
PMID:23106139 PMID:32959702 |
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NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
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G |
SOD2 |
superoxide dismutase 2 |
decreases activity |
ISO |
Aluminum results in decreased activity of SOD2 protein |
CTD |
PMID:19010380 |
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NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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G |
SPP1 |
secreted phosphoprotein 1 |
increases expression |
ISO |
Aluminum results in increased expression of SPP1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
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G |
SPRR1A |
small proline rich protein 1A |
increases expression |
ISO |
Aluminum results in increased expression of SPRR1A mRNA |
CTD |
PMID:37544489 |
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NCBI chr 1:152,984,081...152,985,814
Ensembl chr 1:152,984,081...152,985,814
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G |
SQSTM1 |
sequestosome 1 |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 mRNA] |
CTD |
PMID:34547296 |
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NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
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G |
STAT1 |
signal transducer and activator of transcription 1 |
decreases expression |
ISO |
Aluminum results in decreased expression of STAT1 mRNA; Aluminum results in decreased expression of STAT1 protein |
CTD |
PMID:37544489 |
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NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960
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G |
TF |
transferrin |
multiple interactions increases uptake affects binding |
EXP ISO |
[Aluminum binds to TF protein] which results in decreased uptake of Iron; [Aluminum binds to TF protein] which results in decreased uptake of Manganese; [Aluminum binds to TF protein] which results in increased uptake of Aluminum; [TF protein binds to Aluminum] affects the activity of [TF protein binds to Iron]; [TF protein binds to Aluminum] which results in increased uptake of Aluminum; [TF protein binds to Aluminum] which results in increased uptake of Iron; [TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein; TF protein binds to [Aluminum co-treated with Iron]; TF protein binds to and results in increased uptake of Aluminum TF protein results in increased uptake of Aluminum Aluminum binds to TF protein; TF protein binds to Aluminum TRF protein binds to Aluminum |
CTD |
PMID:1375080 PMID:2039817 PMID:2308257 PMID:8782865 PMID:10978387 PMID:11193083 PMID:12627980 PMID:15149824 PMID:19859668 PMID:22873711 More...
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NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641
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G |
TFRC |
transferrin receptor |
decreases expression affects uptake |
ISO |
Aluminum results in decreased expression of TFRC mRNA TFRC protein affects the uptake of Aluminum |
CTD |
PMID:9630424 PMID:11068183 |
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NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153
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G |
TGFB1 |
transforming growth factor beta 1 |
multiple interactions |
EXP |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of TGFB1 mRNA |
CTD |
PMID:32437896 |
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NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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G |
TNF |
tumor necrosis factor |
increases expression multiple interactions |
ISO EXP |
Aluminum results in increased expression of TNF protein [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA] [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of TNF protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of TNF protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Aluminum results in increased expression of TNF protein] [Titanium co-treated with Vanadium co-treated with Aluminum] results in increased expression of TNF mRNA |
CTD |
PMID:16545059 PMID:17408380 PMID:23690655 PMID:27368151 PMID:29170048 PMID:32959702 PMID:37415728 More...
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
TUBB3 |
tubulin beta 3 class III |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of TUBB3 protein |
CTD |
PMID:31363819 |
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NCBI chr16:89,921,925...89,936,097
Ensembl chr16:89,921,392...89,938,761
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G |
TXN2 |
thioredoxin 2 |
multiple interactions |
EXP |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of TXN2 protein |
CTD |
PMID:31945389 |
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NCBI chr22:36,467,046...36,481,640
Ensembl chr22:36,467,046...36,481,640
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G |
UBA52 |
ubiquitin A-52 residue ribosomal protein fusion product 1 |
decreases expression |
EXP |
Aluminum results in decreased expression of UBA52 mRNA; Aluminum results in decreased expression of UBA52 protein |
CTD |
PMID:27329587 |
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NCBI chr19:18,563,766...18,577,550
Ensembl chr19:18,571,730...18,577,550
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G |
UBE2L6 |
ubiquitin conjugating enzyme E2 L6 |
decreases expression |
ISO |
Aluminum results in decreased expression of UBE2L6 mRNA |
CTD |
PMID:37544489 |
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NCBI chr11:57,551,662...57,567,935
Ensembl chr11:57,551,656...57,568,284
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G |
USP18 |
ubiquitin specific peptidase 18 |
decreases expression |
ISO |
Aluminum results in decreased expression of USP18 mRNA |
CTD |
PMID:37544489 |
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NCBI chr22:18,150,170...18,177,397
Ensembl chr22:18,149,843...18,177,397
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G |
VCAM1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VCAM1 protein; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VCAM1 protein] |
CTD |
PMID:32959702 |
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NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
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G |
VEGFA |
vascular endothelial growth factor A |
multiple interactions |
EXP ISO |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VEGFA protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of and results in increased secretion of VEGFA protein; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased secretion of VEGFA protein [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of VEGFA protein; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of VEGFA protein] |
CTD |
PMID:32437896 PMID:32959702 |
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NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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G |
VIM |
vimentin |
multiple interactions increases expression |
EXP ISO |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM protein Aluminum results in increased expression of VIM mRNA |
CTD |
PMID:32437896 PMID:37544489 |
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NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
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G |
XAF1 |
XIAP associated factor 1 |
decreases expression |
ISO |
Aluminum results in decreased expression of XAF1 mRNA; Aluminum results in decreased expression of XAF1 protein |
CTD |
PMID:37544489 |
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NCBI chr17:6,755,447...6,775,647
Ensembl chr17:6,755,447...6,775,647
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G |
XBP1 |
X-box binding protein 1 |
decreases expression |
ISO |
Aluminum results in decreased expression of XBP1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
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G |
XDH |
xanthine dehydrogenase |
increases activity |
ISO |
Aluminum results in increased activity of XDH protein |
CTD |
PMID:11787993 |
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NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
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G |
ZBP1 |
Z-DNA binding protein 1 |
decreases expression |
ISO |
Aluminum results in decreased expression of ZBP1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr20:57,603,852...57,620,426
Ensembl chr20:57,603,846...57,620,576
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