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G |
Hmbs |
hydroxymethylbilane synthase |
decreases activity |
EXP |
Aluminium ion decreases activity of purified Hmbs protein |
RGD |
PMID:6732900 |
RGD:25394584 |
NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
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G |
Ace |
angiotensin I converting enzyme |
decreases activity |
ISO |
Aluminum results in decreased activity of ACE protein |
CTD |
PMID:12008977 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ache |
acetylcholinesterase |
multiple interactions decreases activity |
EXP |
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium co-treated with Zinc] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased activity of ACHE protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA; Aluminum promotes the reaction [Lead results in decreased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA]; Copper inhibits the reaction [Aluminum results in decreased activity of ACHE protein]; Plant Extracts inhibits the reaction [Aluminum results in decreased activity of ACHE protein] |
CTD |
PMID:15266904 PMID:23354609 PMID:24486960 PMID:29170048 PMID:37415728 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Acly |
ATP citrate lyase |
multiple interactions |
ISO |
Aluminum results in increased expression of and results in increased activity of ACLY protein |
CTD |
PMID:17762189 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
Aco1 |
aconitase 1 |
decreases activity |
EXP |
Aluminum results in decreased activity of ACO1 protein |
CTD |
PMID:10806405 |
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NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
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G |
Aco2 |
aconitase 2 |
decreases activity multiple interactions |
ISO EXP |
Aluminum results in decreased activity of ACO2 protein Aluminum promotes the reaction [Nitroprusside results in decreased activity of ACO2 protein] Aluminum results in decreased expression of and results in decreased activity of ACO2 protein |
CTD |
PMID:12470706 PMID:16906525 PMID:19010380 |
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NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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G |
Alb |
albumin |
affects binding |
ISO |
ALB protein binds to Aluminum |
CTD |
PMID:14507469 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions increases expression |
EXP |
caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein] Aluminum results in increased expression of ALOX5 mRNA; Aluminum results in increased expression of ALOX5 protein |
CTD |
PMID:27368151 |
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NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of ALPL mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of ALPL mRNA] |
CTD |
PMID:34547296 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Apob |
apolipoprotein B |
increases expression |
ISO |
Aluminum results in increased expression of APOB protein |
CTD |
PMID:17762189 |
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NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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G |
App |
amyloid beta precursor protein |
affects binding increases cleavage increases expression multiple interactions |
ISO EXP |
APP protein binds to Aluminum Aluminum results in increased cleavage of APP protein Aluminum results in increased expression of APP protein APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]; meloxicam inhibits the reaction [Aluminum results in increased expression of APP protein]; Vitamin E inhibits the reaction [Aluminum results in increased cleavage of APP protein] Aluminum results in increased expression of APP mRNA [APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] |
CTD |
PMID:12039845 PMID:16308480 PMID:16724269 PMID:16928369 PMID:16942756 PMID:21298039 PMID:29170048 More...
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Atxn3 |
ataxin 3 |
affects folding multiple interactions |
ISO |
Aluminum affects the folding of ATXN3 protein polymorphism Aluminum promotes the reaction [ATXN3 protein polymorphism binds to ATXN3 protein polymorphism] |
CTD |
PMID:17300980 |
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NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902
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G |
Bax |
BCL2 associated X, apoptosis regulator |
affects response to substance multiple interactions |
EXP ISO |
BAX protein affects the susceptibility to Aluminum [aluminum chlorhydrate results in increased abundance of Aluminum] which affects the expression of BAX protein [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX protein] |
CTD |
PMID:20385067 PMID:31945389 PMID:34547296 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bbox1 |
gamma-butyrobetaine hydroxylase 1 |
multiple interactions decreases expression |
ISO |
Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Ketoglutaric Acids inhibits the reaction [Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]] Aluminum results in decreased expression of BBOX1 protein |
CTD |
PMID:21439360 |
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NCBI chr 3:96,822,654...96,871,786
Ensembl chr 3:96,822,655...96,871,458
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein; Fulvestrant inhibits the reaction [[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein] [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein] |
CTD |
PMID:31945389 PMID:34547296 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2L1 protein |
CTD |
PMID:31945389 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bglap |
bone gamma-carboxyglutamate protein |
multiple interactions decreases secretion |
EXP ISO |
Aluminum inhibits the reaction [Calcitriol results in increased secretion of BGLAP protein]; Calcitriol inhibits the reaction [Aluminum results in decreased secretion of BGLAP protein] [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP protein] |
CTD |
PMID:9626627 PMID:34547296 |
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NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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G |
Bgn |
biglycan |
increases expression |
ISO |
Aluminum results in increased expression of BGN mRNA |
CTD |
PMID:37544489 |
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NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461
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G |
Cald1 |
caldesmon 1 |
increases expression |
ISO |
Aluminum results in increased expression of CALD1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932
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G |
Casp12 |
caspase 12 |
multiple interactions |
ISO |
[aluminum chloride results in increased abundance of Aluminum] which results in increased expression of CASP12 mRNA |
CTD |
PMID:29635646 |
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
increases expression multiple interactions |
ISO EXP |
Aluminum results in increased expression of CASP3 [Aluminum Chloride results in increased abundance of Aluminum] which results in increased cleavage of CASP3 protein; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CASP3 mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CASP3 mRNA] [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of CASP3 protein |
CTD |
PMID:21972528 PMID:34547296 PMID:37415728 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of CASP9 protein; Fulvestrant inhibits the reaction [[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of CASP9 protein] |
CTD |
PMID:31945389 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Casr |
calcium-sensing receptor |
multiple interactions |
EXP |
[Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; [Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates; Aluminum binds to and results in increased activity of CASR protein |
CTD |
PMID:10231437 |
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NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
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G |
Cat |
catalase |
decreases activity multiple interactions |
ISO EXP |
Aluminum results in decreased activity of CAT protein Vitamin E inhibits the reaction [Aluminum results in decreased activity of CAT protein] [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased activity of CAT protein; CAT protein results in decreased susceptibility to [Tyramine co-treated with Aluminum]; Plant Extracts inhibits the reaction [Aluminum results in decreased activity of CAT protein] [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased activity of CAT protein] |
CTD |
PMID:15526171 PMID:17709913 PMID:24486960 PMID:34547296 PMID:37415728 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
decreases expression |
ISO |
Aluminum results in decreased expression of CCL7 mRNA |
CTD |
PMID:37544489 |
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NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 protein |
CTD |
PMID:32437896 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Chat |
choline O-acetyltransferase |
decreases expression decreases activity multiple interactions |
ISO |
Aluminum results in decreased expression of CHAT protein Aluminum results in decreased activity of CHAT protein APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]; meloxicam inhibits the reaction [Aluminum results in decreased expression of CHAT protein] |
CTD |
PMID:16724269 PMID:16928369 |
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NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions decreases expression |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of COL1A1 mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of COL1A1 mRNA] Aluminum results in decreased expression of COL1A1 mRNA |
CTD |
PMID:34547296 PMID:37544489 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Crp |
C-reactive protein |
multiple interactions |
ISO |
[Zinc co-treated with Aluminum] results in increased expression of CRP protein; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of CRP protein |
CTD |
PMID:27816692 |
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NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
increases expression |
ISO |
Aluminum results in increased expression of CX3CL1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CYCS mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CYCS mRNA] |
CTD |
PMID:34547296 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Daxx |
death-domain associated protein |
increases expression |
ISO |
Aluminum results in increased expression of DAXX mRNA |
CTD |
PMID:16308480 |
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NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
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G |
Drd1 |
dopamine receptor D1 |
multiple interactions |
EXP |
Aluminum inhibits the reaction [SCH 23390 binds to DRD1 protein] |
CTD |
PMID:9109525 |
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NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
EXP |
Aluminum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein] |
CTD |
PMID:9109525 |
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Ecm1 |
extracellular matrix protein 1 |
increases expression |
ISO |
Aluminum results in increased expression of ECM1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
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G |
Egln3 |
egl-9 family hypoxia-inducible factor 3 |
increases expression |
ISO |
Aluminum results in increased expression of EGLN3 mRNA; Aluminum results in increased expression of EGLN3 protein |
CTD |
PMID:37544489 |
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NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
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G |
Eno2 |
enolase 2 |
decreases activity |
ISO |
Aluminum results in decreased activity of ENO2 protein |
CTD |
PMID:11860913 |
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NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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G |
Epor |
erythropoietin receptor |
affects expression |
ISO |
Aluminum affects the expression of EPOR protein |
CTD |
PMID:15777837 |
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NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; [aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [NRG1 protein results in increased phosphorylation of ESR1 protein]; [aluminum chlorhydrate results in increased abundance of Aluminum] which results in increased expression of ESR1 protein; [Estradiol co-treated with [aluminum chlorhydrate results in increased abundance of Aluminum]] results in increased expression of ESR1 protein |
CTD |
PMID:31945389 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
[[aluminum chlorhydrate results in increased abundance of Aluminum] co-treated with [Tretinoin co-treated with Estradiol]] affects the localization of ESR2 protein; [[aluminum chlorhydrate results in increased abundance of Aluminum] which co-treated with Tretinoin] results in decreased expression of and affects the localization of ESR2 protein; [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of and affects the localization of ESR2 protein; [Estradiol co-treated with [aluminum chlorhydrate results in increased abundance of Aluminum]] results in decreased expression of ESR2 protein |
CTD |
PMID:31945389 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
F8 |
coagulation factor VIII |
affects folding multiple interactions |
ISO |
Aluminum affects the folding of F8 protein [Aluminum promotes the reaction [F8 protein binds to F8 protein]] which results in decreased activity of F8 protein |
CTD |
PMID:15349964 |
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NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857
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G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
increases expression |
ISO |
Aluminum results in increased expression of FDFT1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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G |
Fh |
fumarate hydratase |
multiple interactions |
ISO |
Aluminum results in decreased expression of and results in decreased activity of FH protein |
CTD |
PMID:16906525 |
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NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein] |
CTD |
PMID:23690655 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
ISO |
Aluminum results in increased expression of FOSL1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases activity |
ISO EXP |
Aluminum results in increased activity of G6PD protein |
CTD |
PMID:16572710 PMID:16979867 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gbp4 |
guanylate binding protein 4 |
decreases expression |
ISO |
Aluminum results in decreased expression of GBP3 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879
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G |
Gchfr |
GTP cyclohydrolase I feedback regulator |
increases expression |
ISO |
Aluminum results in increased expression of GCHFR mRNA |
CTD |
PMID:37544489 |
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NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080
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G |
Gfap |
glial fibrillary acidic protein |
increases expression multiple interactions |
EXP ISO |
Aluminum results in increased expression of GFAP protein Vitamin E inhibits the reaction [Aluminum results in increased expression of GFAP protein] [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of GFAP protein |
CTD |
PMID:16545059 PMID:31363819 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gnai1 |
G protein subunit alpha i1 |
decreases expression |
EXP |
Aluminum results in decreased expression of GNAI1 protein |
CTD |
PMID:9626627 |
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NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
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G |
Gnai2 |
G protein subunit alpha i2 |
decreases expression |
EXP |
Aluminum results in decreased expression of GNAI2 protein |
CTD |
PMID:9626627 |
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NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
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G |
Gnaq |
G protein subunit alpha q |
increases response to substance |
ISO |
GNAQ protein results in increased susceptibility to Aluminum |
CTD |
PMID:15068510 |
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NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
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G |
Gpd1 |
glycerol-3-phosphate dehydrogenase 1 |
multiple interactions |
ISO |
Aluminum results in increased expression of and results in increased activity of GPD1 protein |
CTD |
PMID:17762189 |
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NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
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G |
Gpx1 |
glutathione peroxidase 1 |
decreases activity multiple interactions |
ISO |
Aluminum results in decreased activity of GPX1 protein Vitamin E inhibits the reaction [Aluminum results in decreased activity of GPX1 protein] |
CTD |
PMID:17709913 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gsr |
glutathione-disulfide reductase |
decreases expression multiple interactions |
EXP |
Aluminum results in decreased expression of GSR protein Plant Extracts inhibits the reaction [Aluminum results in decreased expression of GSR protein] |
CTD |
PMID:24486960 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases localization |
ISO |
Aluminum results in increased localization of HIF1A protein |
CTD |
PMID:16979867 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hk1 |
hexokinase 1 |
multiple interactions decreases activity |
EXP |
Meclofenoxate inhibits the reaction [Aluminum results in decreased activity of HK1 protein] |
CTD |
PMID:16969689 |
|
NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131
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G |
Hmga1 |
high mobility group AT-hook 1 |
increases expression |
ISO |
Aluminum results in increased expression of HMGA1 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752
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G |
Idh1 |
isocitrate dehydrogenase (NADP(+)) 1 |
decreases activity |
EXP |
Aluminum results in decreased activity of IDH1 protein |
CTD |
PMID:15486972 |
|
NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
decreases activity |
EXP |
Aluminum results in decreased activity of IDH2 protein |
CTD |
PMID:15486972 |
|
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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G |
Ifi27l2a |
interferon, alpha-inducible protein 27 like 2A |
decreases expression |
ISO |
Aluminum results in decreased expression of IFI27L2A mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 6:122,598,872...122,600,358
Ensembl chr 6:122,598,872...122,600,360
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G |
Ifi35 |
interferon-induced protein 35 |
decreases expression |
ISO |
Aluminum results in decreased expression of IFI35 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952
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G |
Ifit3 |
interferon-induced protein with tetratricopeptide repeats 3 |
decreases expression |
ISO |
Aluminum results in decreased expression of IFIT3 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
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|
G |
Ifnb1 |
interferon beta 1 |
multiple interactions |
ISO |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IFNB1 mRNA] |
CTD |
PMID:23690655 |
|
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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|
G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO |
Aluminum inhibits the reaction [IGF1 protein results in increased activity of MTR protein] |
CTD |
PMID:14745455 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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|
G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B mRNA] |
CTD |
PMID:23690655 |
|
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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|
G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
EXP |
[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]; Vitamin E inhibits the reaction [Aluminum results in increased expression of IL1B protein] |
CTD |
PMID:16545059 PMID:27368151 PMID:29170048 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il4 |
interleukin 4 |
increases expression |
ISO |
Aluminum results in increased expression of IL4 mRNA |
CTD |
PMID:16630673 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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|
G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
EXP ISO |
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of IL6 protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein] [Zinc co-treated with Aluminum] results in increased expression of IL6 protein; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of IL6 protein |
CTD |
PMID:27368151 PMID:27816692 PMID:29170048 PMID:37415728 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irf7 |
interferon regulatory factor 7 |
decreases expression |
ISO |
Aluminum results in decreased expression of IRF7 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
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G |
Isg15 |
ISG15 ubiquitin-like modifier |
decreases expression |
ISO |
Aluminum results in decreased expression of ISG15 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein] |
CTD |
PMID:23690655 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Klk1 |
kallikrein 1 |
multiple interactions |
ISO |
Aluminum binds to and results in decreased activity of KLK1 protein |
CTD |
PMID:15558947 |
|
NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754
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|
G |
Litaf |
lipopolysaccharide-induced TNF factor |
multiple interactions |
ISO |
[Titanium co-treated with Vanadium co-treated with Aluminum] results in increased expression of LITAF mRNA |
CTD |
PMID:17408380 |
|
NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
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|
G |
Lonrf2 |
LON peptidase N-terminal domain and ring finger 2 |
decreases expression |
EXP |
Aluminum results in decreased expression of LONRF2 mRNA |
CTD |
PMID:19010380 |
|
NCBI chr 9:41,033,125...41,070,551
Ensembl chr 9:41,034,628...41,070,649
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G |
Manf |
mesencephalic astrocyte-derived neurotrophic factor |
decreases expression |
ISO |
Aluminum results in decreased expression of MANF mRNA; Aluminum results in decreased expression of MANF protein |
CTD |
PMID:37544489 |
|
NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MAP1LC3B mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased lipidation of MAP1LC3B protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MAP1LC3B mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased lipidation of MAP1LC3B protein] |
CTD |
PMID:34547296 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
[Aluminum co-treated with Iron] results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:16728372 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapt |
microtubule-associated protein tau |
increases phosphorylation multiple interactions |
EXP |
Aluminum results in increased phosphorylation of MAPT protein [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] |
CTD |
PMID:17662457 PMID:29170048 |
|
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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|
G |
Mir21 |
microRNA 21 |
multiple interactions |
ISO |
[Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR21 mRNA |
CTD |
PMID:27506416 |
|
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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|
G |
Mir30d |
microRNA 30d |
multiple interactions |
ISO |
[Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR30D mRNA |
CTD |
PMID:27506416 |
|
NCBI chr 7:100,136,391...100,136,472
Ensembl chr 7:100,136,391...100,136,472
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G |
Mir322 |
microRNA 322 |
multiple interactions |
ISO |
[Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR424 mRNA |
CTD |
PMID:27506416 |
|
NCBI chr X:132,806,594...132,806,688
Ensembl chr X:132,806,594...132,806,688
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G |
Mmp2 |
matrix metallopeptidase 2 |
increases expression |
EXP |
Aluminum results in increased expression of MMP2 protein |
CTD |
PMID:16052892 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp7 |
matrix metallopeptidase 7 |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MMP7 mRNA |
CTD |
PMID:32437896 |
|
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression multiple interactions |
EXP ISO |
Aluminum results in increased expression of MMP9 protein [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MMP9 mRNA |
CTD |
PMID:16052892 PMID:32437896 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpo |
myeloperoxidase |
increases expression |
ISO |
Aluminum results in increased expression of MPO protein |
CTD |
PMID:17402216 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mrpl20 |
mitochondrial ribosomal protein L20 |
decreases expression |
ISO |
Aluminum results in decreased expression of MRPL20 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 5:166,408,962...166,413,492
Ensembl chr 5:166,408,962...166,413,492
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G |
Msmo1 |
methylsterol monooxygenase 1 |
increases expression |
ISO |
Aluminum results in increased expression of MSMO1 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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G |
Mtr |
5-methyltetrahydrofolate-homocysteine methyltransferase |
multiple interactions |
ISO |
Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Aluminum inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; Aluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form] |
CTD |
PMID:14745455 PMID:26989453 |
|
NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
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|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
ISO |
Aluminum results in increased expression of MYC mRNA; Aluminum results in increased expression of MYC protein |
CTD |
PMID:37544489 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFE2L2 protein |
CTD |
PMID:37415728 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFKB1 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFKB1 protein |
CTD |
PMID:37415728 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP ISO |
[Aluminum co-treated with Iron] results in increased expression of NOS2 protein [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] |
CTD |
PMID:16728372 PMID:23690655 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nrg1 |
neuregulin 1 |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [NRG1 protein results in increased phosphorylation of ESR1 protein] |
CTD |
PMID:31945389 |
|
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
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G |
Oas1a |
2'-5' oligoadenylate synthetase 1A |
decreases expression |
ISO |
Aluminum results in decreased expression of OAS1G mRNA |
CTD |
PMID:37544489 |
|
NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
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G |
Ogdh |
oxoglutarate dehydrogenase |
multiple interactions increases activity |
ISO EXP |
Aluminum results in decreased expression of and results in decreased activity of OGDH protein Aluminum results in increased activity of OGDH protein |
CTD |
PMID:10806405 PMID:16906525 |
|
NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
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G |
Oprd1 |
opioid receptor, delta 1 |
multiple interactions |
EXP |
[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in decreased abundance of Aluminum |
CTD |
PMID:7477890 |
|
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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|
G |
Parp10 |
poly (ADP-ribose) polymerase family, member 10 |
decreases expression |
ISO |
Aluminum results in decreased expression of PARP10 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr 7:107,949,031...107,958,377
Ensembl chr 7:107,949,043...107,958,304
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|
G |
Parp9 |
poly (ADP-ribose) polymerase family, member 9 |
decreases expression |
ISO |
Aluminum results in decreased expression of PARP9 mRNA; Aluminum results in decreased expression of PARP9 protein |
CTD |
PMID:37544489 |
|
NCBI chr11:64,780,977...64,814,995
Ensembl chr11:64,780,981...64,815,455
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of PCK1 protein |
CTD |
PMID:31945389 |
|
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
[aluminum chloride results in increased abundance of Aluminum] which results in decreased expression of PCNA mRNA |
CTD |
PMID:29635646 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pcyt2 |
phosphate cytidylyltransferase 2, ethanolamine |
increases expression |
ISO |
Aluminum results in increased expression of PCYT2 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr10:105,888,769...105,896,182
Ensembl chr10:105,888,775...105,896,172
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G |
Pink1 |
PTEN induced kinase 1 |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 mRNA] |
CTD |
PMID:34547296 |
|
NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
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|
G |
Pklr |
pyruvate kinase L/R |
increases activity |
ISO |
Aluminum results in increased activity of PKLR protein |
CTD |
PMID:16979867 |
|
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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|
G |
Plcd1 |
phospholipase C, delta 1 |
increases expression |
EXP |
Aluminum results in increased expression of PLCD1 protein |
CTD |
PMID:10814511 |
|
NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186
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G |
Prkg2 |
protein kinase cGMP-dependent 2 |
increases expression |
ISO |
Aluminum results in increased expression of PRKG2 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888
|
|
G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN mRNA] |
CTD |
PMID:34547296 |
|
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
|
|
G |
Psmb8 |
proteasome 20S subunit beta 8 |
decreases expression |
ISO |
Aluminum results in decreased expression of PSMB8 mRNA; Aluminum results in decreased expression of PSMB8 protein |
CTD |
PMID:37544489 |
|
NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283
|
|
G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
increases expression |
ISO |
Aluminum results in increased expression of PTGS1 mRNA; Aluminum results in increased expression of PTGS1 protein |
CTD |
PMID:37544489 |
|
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
ISO |
Aluminum results in increased expression of PTGS2 mRNA; Aluminum results in increased expression of PTGS2 protein [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 protein] |
CTD |
PMID:16928369 PMID:23690655 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Pth |
parathyroid hormone |
multiple interactions |
ISO |
[TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein |
CTD |
PMID:10978387 |
|
NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
|
|
G |
Rcvrn |
recoverin |
multiple interactions |
ISO |
[APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA |
CTD |
PMID:21298039 |
|
NCBI chr10:52,388,706...52,396,454
Ensembl chr10:52,388,706...52,396,453
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] |
CTD |
PMID:23690655 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Rpl37 |
ribosomal protein L37 |
decreases expression |
ISO |
Aluminum results in decreased expression of RPL37 mRNA; Aluminum results in decreased expression of RPL37 protein |
CTD |
PMID:27329587 |
|
NCBI chr 2:54,215,469...54,217,429
Ensembl chr 2:54,215,469...54,217,442
|
|
G |
Rtp4 |
receptor (chemosensory) transporter protein 4 |
decreases expression |
ISO |
Aluminum results in decreased expression of RTP4 mRNA |
CTD |
PMID:37544489 |
|
NCBI chr11:77,237,341...77,249,194
Ensembl chr11:77,238,216...77,335,437
|
|
G |
S100b |
S100 calcium binding protein B |
increases expression multiple interactions |
EXP |
Aluminum results in increased expression of S100B protein Vitamin E inhibits the reaction [Aluminum results in increased expression of S100B protein] |
CTD |
PMID:16545059 |
|
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
|
|
G |
Scgb1a1 |
secretoglobin family 1A member 1 |
decreases expression |
EXP ISO |
Aluminum results in decreased expression of SCGB1A1 protein |
CTD |
PMID:16052892 PMID:16099050 |
|
NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
|
|
G |
Shisa5 |
shisa family member 5 |
decreases expression |
ISO |
Aluminum results in decreased expression of SHISA5 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 8:109,691,504...109,706,411
Ensembl chr 8:109,691,522...109,706,408
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Slc2a1 |
solute carrier family 2 member 1 |
increases expression |
ISO |
Aluminum results in increased expression of SLC2A1 protein |
CTD |
PMID:16979867 |
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NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Snai1 |
snail family transcriptional repressor 1 |
multiple interactions |
ISO |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 protein |
CTD |
PMID:32437896 |
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NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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Snca |
synuclein alpha |
affects response to substance |
ISO |
SNCA protein affects the susceptibility to Aluminum |
CTD |
PMID:23106139 |
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NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Sod2 |
superoxide dismutase 2 |
decreases activity |
EXP |
Aluminum results in decreased activity of SOD2 protein |
CTD |
PMID:19010380 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Spp1 |
secreted phosphoprotein 1 |
increases expression |
ISO |
Aluminum results in increased expression of SPP1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Sprr1a |
small proline-rich protein 1A |
increases expression |
ISO |
Aluminum results in increased expression of SPRR1A mRNA |
CTD |
PMID:37544489 |
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NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063
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Sqstm1 |
sequestosome 1 |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 mRNA] |
CTD |
PMID:34547296 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Stat1 |
signal transducer and activator of transcription 1 |
decreases expression |
ISO |
Aluminum results in decreased expression of STAT1 mRNA; Aluminum results in decreased expression of STAT1 protein |
CTD |
PMID:37544489 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Tf |
transferrin |
multiple interactions increases uptake affects binding |
ISO |
[Aluminum binds to TF protein] which results in decreased uptake of Iron; [Aluminum binds to TF protein] which results in decreased uptake of Manganese; [Aluminum binds to TF protein] which results in increased uptake of Aluminum; [TF protein binds to Aluminum] affects the activity of [TF protein binds to Iron]; [TF protein binds to Aluminum] which results in increased uptake of Aluminum; [TF protein binds to Aluminum] which results in increased uptake of Iron; [TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein; TF protein binds to [Aluminum co-treated with Iron]; TF protein binds to and results in increased uptake of Aluminum TF protein results in increased uptake of Aluminum Aluminum binds to TF protein; TF protein binds to Aluminum TRF protein binds to Aluminum |
CTD |
PMID:1375080 PMID:2039817 PMID:2308257 PMID:8782865 PMID:10978387 PMID:11193083 PMID:12627980 PMID:15149824 PMID:19859668 PMID:22873711 More...
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NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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Tfrc |
transferrin receptor |
decreases expression affects uptake |
EXP |
Aluminum results in decreased expression of TFRC mRNA TFRC protein affects the uptake of Aluminum |
CTD |
PMID:9630424 PMID:11068183 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of TGFB1 mRNA |
CTD |
PMID:32437896 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf |
tumor necrosis factor |
increases expression multiple interactions |
EXP ISO |
Aluminum results in increased expression of TNF protein [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA] [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of TNF protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Aluminum results in increased expression of TNF protein] [Titanium co-treated with Vanadium co-treated with Aluminum] results in increased expression of TNF mRNA |
CTD |
PMID:16545059 PMID:17408380 PMID:23690655 PMID:27368151 PMID:29170048 PMID:37415728 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tubb3 |
tubulin, beta 3 class III |
multiple interactions |
ISO |
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of TUBB3 protein |
CTD |
PMID:31363819 |
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NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
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Txn2 |
thioredoxin 2 |
multiple interactions |
ISO |
[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of TXN2 protein |
CTD |
PMID:31945389 |
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NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
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Uba52 |
ubiquitin A-52 residue ribosomal protein fusion product 1 |
decreases expression |
ISO |
Aluminum results in decreased expression of UBA52 mRNA; Aluminum results in decreased expression of UBA52 protein |
CTD |
PMID:27329587 |
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NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
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Ube2l6 |
ubiquitin-conjugating enzyme E2L 6 |
decreases expression |
ISO |
Aluminum results in decreased expression of UBE2L6 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 3:69,873,025...69,888,042
Ensembl chr 3:69,873,424...69,888,048
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Usp18 |
ubiquitin specific peptidase 18 |
decreases expression |
ISO |
Aluminum results in decreased expression of USP18 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
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Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VEGFA protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of and results in increased secretion of VEGFA protein; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased secretion of VEGFA protein |
CTD |
PMID:32437896 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vim |
vimentin |
multiple interactions increases expression |
ISO |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM protein Aluminum results in increased expression of VIM mRNA |
CTD |
PMID:32437896 PMID:37544489 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Xaf1 |
XIAP associated factor 1 |
decreases expression |
ISO |
Aluminum results in decreased expression of XAF1 mRNA; Aluminum results in decreased expression of XAF1 protein |
CTD |
PMID:37544489 |
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NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770
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Xbp1 |
X-box binding protein 1 |
decreases expression |
ISO |
Aluminum results in decreased expression of XBP1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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Xdh |
xanthine dehydrogenase |
increases activity |
EXP |
Aluminum results in increased activity of XDH protein |
CTD |
PMID:11787993 |
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NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Zbp1 |
Z-DNA binding protein 1 |
decreases expression |
ISO |
Aluminum results in decreased expression of ZBP1 mRNA |
CTD |
PMID:37544489 |
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NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:161,993,351...162,003,870
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