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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-methylthio-2-oxobutanoic acid
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Accession:CHEBI:33574 term browser browse the term
Definition:A 2-oxo monocarboxylic acid derived from L-methionine via the action of methionine transaminase.
Synonyms:related_synonym: 2-Oxo-4-methylthiobutanoate;   2-keto-4-methylthiobutyric acid;   2-oxomethionine;   4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID;   4-Methylthio-2-oxobutanoate;   Formula=C5H8O3S;   InChI=1S/C5H8O3S/c1-9-3-2-4(6)5(7)8/h2-3H2,1H3,(H,7,8);   InChIKey=SXFSQZDSUWACKX-UHFFFAOYSA-N;   SMILES=CSCCC(=O)C(O)=O;   alpha-oxo-gamma-methylthiobutyric acid
 alt_id: CHEBI:1902;   CHEBI:22458;   CHEBI:43720
 xref: Beilstein:1754666;   CAS:583-92-6;   DrugBank:DB02238;   KEGG:C01180;   KNApSAcK:C00007474;   LIPID_MAPS_instance:LMFA01060170
 xref_mesh: MESH:C014632
 xref: PDBeChem:KMT
 cyclic_relationship: is_conjugate_acid_of CHEBI:16723


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4-methylthio-2-oxobutanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctbp2 C-terminal binding protein 2 decreases expression ISO 2-keto-4-methylthiobutyric acid results in decreased expression of CTBP2 protein CTD PMID:28414304 NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO 2-keto-4-methylthiobutyric acid results in decreased expression of CTNNB1 protein CTD PMID:28414304 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Kyat1 kynurenine aminotransferase 1 affects metabolic processing EXP KYAT1 protein affects the metabolism of 2-keto-4-methylthiobutyric acid CTD PMID:2711386 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355 		JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity ISO 2-keto-4-methylthiobutyric acid results in decreased activity of ODC1 protein CTD PMID:16870157 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            nutraceutical 13372
              L-methionine 3534
                4-methylthio-2-oxobutanoic acid 4
                  S-adenosyl-4-methylthio-2-oxobutanoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      monocarboxylic acid 18004
                                        fatty acid 16838
                                          short-chain fatty acid 15927
                                            fatty acid 4:0 8227
                                              butyric acid 6725
                                                methionine 3535
                                                  L-methionine 3534
                                                    4-methylthio-2-oxobutanoic acid 4
                                                      S-adenosyl-4-methylthio-2-oxobutanoic acid 0
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