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G |
ACADM |
acyl-CoA dehydrogenase medium chain |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ACADM mRNA |
CTD |
PMID:34416349 |
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NCBI chr 6:137,541,481...137,575,544
Ensembl chr 6:137,541,381...137,595,108
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G |
ACOX1 |
acyl-CoA oxidase 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ACOX1 mRNA |
CTD |
PMID:34416349 |
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NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,439,361...5,479,546
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G |
AKT1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of AKT1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:33493553 |
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G |
ALOX15 |
arachidonate 15-lipoxygenase |
increases expression |
EXP |
Cadmium Chloride results in increased expression of ALOX15 mRNA |
CTD |
PMID:33626375 |
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NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,287,160...52,295,871
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G |
ALOX5 |
arachidonate 5-lipoxygenase |
increases expression |
EXP |
Cadmium Chloride results in increased expression of ALOX5 mRNA |
CTD |
PMID:33626375 |
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NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,016...90,907,094
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G |
AQP1 |
aquaporin 1 (Colton blood group) |
increases expression |
EXP |
Cadmium Chloride results in increased expression of AQP1 mRNA |
CTD |
PMID:20576581 |
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NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,485...42,076,746
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G |
ARG1 |
arginase 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ARG1 mRNA |
CTD |
PMID:34416349 |
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NCBI chr 1:32,006,035...32,028,983
Ensembl chr 1:32,006,046...32,028,988
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G |
ATF4 |
activating transcription factor 4 |
multiple interactions increases expression |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF4 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF4 protein; Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of ATF4 protein] Cadmium Chloride results in increased expression of ATF4; Cadmium Chloride results in increased expression of ATF4 mRNA; Cadmium Chloride results in increased expression of ATF4 protein |
CTD |
PMID:16759985 PMID:20600546 PMID:33891997 |
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NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
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G |
ATF6 |
activating transcription factor 6 |
increases cleavage multiple interactions |
EXP |
Cadmium Chloride results in increased cleavage of ATF6 protein 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased cleavage of ATF6 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF6 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF6 protein |
CTD |
PMID:17464326 PMID:33891997 |
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NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304
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G |
BAK1 |
BCL2 antagonist/killer 1 |
multiple interactions increases expression |
EXP |
[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAK1 mRNA; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein] |
CTD |
PMID:26607349 PMID:33493553 |
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NCBI chr 7:29,808,849...29,815,345
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G |
BAX |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
EXP |
Cadmium Chloride results in increased expression of BAX protein [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein] |
CTD |
PMID:26607349 PMID:33493553 |
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NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
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G |
BBC3 |
BCL2 binding component 3 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BBC3 mRNA |
CTD |
PMID:33891997 |
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NCBI chr 6:53,037,103...53,046,902
Ensembl chr 6:53,037,104...53,046,887
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G |
BCL2 |
BCL2 apoptosis regulator |
increases expression decreases expression multiple interactions |
EXP |
Cadmium Chloride results in increased expression of BCL2 protein Cadmium Chloride results in decreased expression of BCL2 protein [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein; Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein] |
CTD |
PMID:23575899 PMID:26607349 PMID:33493553 |
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NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
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G |
BCL2L11 |
BCL2 like 11 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BCL2L11 mRNA |
CTD |
PMID:33891997 |
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NCBI chr 3:45,156,791...45,202,996
Ensembl chr 3:45,160,155...45,201,186
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G |
CASP1 |
caspase 1, apoptosis-related cysteine peptidase |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein |
CTD |
PMID:33592257 PMID:34416349 |
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NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
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G |
CASP3 |
caspase 3 |
multiple interactions increases activity increases expression increases cleavage |
EXP |
[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased cleavage of CASP3 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP3 protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; oxalomalic acid promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; Selenium inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein] |
CTD |
PMID:16785314 PMID:17383151 PMID:26607349 PMID:33493553 PMID:33891997 PMID:34416349 More...
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NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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G |
CASP9 |
caspase 9 |
increases expression multiple interactions |
EXP |
Cadmium Chloride results in increased expression of CASP9 protein [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP9 mRNA; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein] |
CTD |
PMID:26607349 PMID:33493553 PMID:33891997 |
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NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
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G |
CAT |
catalase |
decreases activity decreases expression multiple interactions |
EXP |
Cadmium Chloride results in decreased activity of CAT protein Cadmium Chloride results in decreased expression of CAT mRNA [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CAT mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CAT mRNA; CAT inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA] |
CTD |
PMID:18086661 PMID:23904328 PMID:33493553 PMID:33626375 PMID:34416349 |
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NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
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G |
CCL2 |
chemokine (C-C motif) ligand 2 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCL2 mRNA |
CTD |
PMID:34416349 |
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NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
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G |
CCL24 |
C-C motif chemokine ligand 24 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CCL24 mRNA |
CTD |
PMID:34416349 |
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NCBI chr 3:10,347,397...10,361,500
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G |
CLIC5 |
chloride intracellular channel 5 |
decreases expression multiple interactions increases degradation |
EXP |
Cadmium Chloride results in decreased expression of CLIC5 mRNA; Cadmium Chloride results in decreased expression of CLIC5 protein bafilomycin A inhibits the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]; Cycloheximide promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein] Cadmium Chloride results in increased degradation of CLIC5 protein |
CTD |
PMID:20576581 |
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NCBI chr 7:40,683,044...40,808,017
Ensembl chr 7:40,682,907...40,863,886
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G |
COL3A1 |
collagen type III alpha 1 chain |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of COL3A1 mRNA |
CTD |
PMID:34416349 |
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NCBI chr15:93,556,914...93,595,678
Ensembl chr15:93,526,603...93,596,363
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G |
COL4A1 |
collagen type IV alpha 1 chain |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of COL4A1 mRNA |
CTD |
PMID:34416349 |
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NCBI chr11:76,858,332...76,997,409
Ensembl chr11:76,858,356...76,997,322
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G |
CORT |
cortistatin |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CORT protein |
CTD |
PMID:34416349 |
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NCBI chr 6:70,716,630...70,717,980
Ensembl chr 6:70,716,386...70,718,032
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G |
COX4I1 |
cytochrome c oxidase subunit 4I1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of COX4 mRNA |
CTD |
PMID:34416349 |
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NCBI chr 6:3,131,017...3,137,619
Ensembl chr 6:3,131,019...3,137,530
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G |
CPT1A |
carnitine palmitoyltransferase 1A |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CPT1A mRNA |
CTD |
PMID:34416349 |
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NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,911
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G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
increases expression multiple interactions |
EXP |
Cadmium Chloride results in increased expression of CXCL8 mRNA [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CXCL8 mRNA |
CTD |
PMID:33626375 PMID:33891997 |
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NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
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G |
CXCL9 |
C-X-C motif chemokine ligand 9 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CXCL9 mRNA |
CTD |
PMID:34416349 |
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NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271
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G |
CYCS |
cytochrome c, somatic |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CYCS mRNA |
CTD |
PMID:33493553 |
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NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
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G |
DDIT3 |
DNA damage inducible transcript 3 |
increases expression multiple interactions |
EXP |
Cadmium Chloride results in increased expression of DDIT3 mRNA 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DDIT3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DDIT3 protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA] |
CTD |
PMID:17464326 PMID:18086661 PMID:33891997 |
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NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
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G |
DENR |
density regulated re-initiation and release factor |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DENR mRNA |
CTD |
PMID:33592257 |
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NCBI chr14:30,070,810...30,084,997
Ensembl chr14:30,069,487...30,084,949
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G |
EGR1 |
early growth response 1 |
increases expression |
EXP |
Cadmium Chloride results in increased expression of EGR1 mRNA |
CTD |
PMID:7564105 |
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NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296
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G |
EIF2A |
eukaryotic translation initiation factor 2A |
increases phosphorylation multiple interactions |
EXP |
Cadmium Chloride results in increased phosphorylation of EIF2A protein [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2A protein |
CTD |
PMID:16759985 PMID:17464326 PMID:33891997 |
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NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,274
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G |
EIF2AK3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
increases phosphorylation multiple interactions |
EXP |
Cadmium Chloride results in increased phosphorylation of EIF2AK3 protein [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2AK3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2AK3 protein |
CTD |
PMID:17464326 PMID:33891997 |
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NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245
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G |
EIF2S1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation |
EXP |
Cadmium Chloride results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:20600546 |
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NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827
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G |
ERN1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ERN1 protein |
CTD |
PMID:33891997 |
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NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284
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G |
ERO1A |
endoplasmic reticulum oxidoreductase 1 alpha |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ERO1A mRNA |
CTD |
PMID:33891997 |
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NCBI chr 1:182,268,651...182,318,147
Ensembl chr 1:182,265,261...182,318,195
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G |
FGD4 |
FYVE, RhoGEF and PH domain containing 4 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DNM1L mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DNM1L protein |
CTD |
PMID:33493553 |
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NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028
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G |
FIS1 |
fission, mitochondrial 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FIS1 mRNA |
CTD |
PMID:33592257 |
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NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955
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G |
FN1 |
fibronectin 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of FN1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of FN1 protein |
CTD |
PMID:34416349 |
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NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014
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G |
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP |
Cadmium Chloride results in increased expression of FOS mRNA 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] |
CTD |
PMID:7564105 PMID:18086661 |
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NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
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G |
GCLC |
glutamate-cysteine ligase catalytic subunit |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GCLC mRNA |
CTD |
PMID:33493553 |
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NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
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G |
GCLM |
glutamate-cysteine ligase modifier subunit |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GCLM mRNA |
CTD |
PMID:33493553 |
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NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131
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G |
GLRX |
glutaredoxin |
decreases activity multiple interactions |
EXP |
Cadmium Chloride results in decreased activity of GLRX protein GLRX protein inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; IDH2 protein inhibits the reaction [Cadmium Chloride results in decreased activity of GLRX protein]; oxalomalic acid promotes the reaction [Cadmium Chloride results in decreased activity of GLRX protein] |
CTD |
PMID:16785314 |
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NCBI chr 2:102,425,580...102,437,851
Ensembl chr 2:102,425,580...102,437,858
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G |
GPX1 |
glutathione peroxidase 1 |
multiple interactions decreases expression |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GPX1 mRNA Cadmium Chloride results in decreased expression of GPX1 mRNA |
CTD |
PMID:33493553 PMID:33626375 |
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NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
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G |
GPX4 |
glutathione peroxidase 4 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GPX4 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GPX4 mRNA |
CTD |
PMID:33493553 PMID:34416349 |
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NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931
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G |
GSTO1 |
glutathione S-transferase omega 1 |
decreases expression multiple interactions |
EXP |
Cadmium Chloride results in decreased expression of GSTO1 mRNA [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GSTO1 mRNA |
CTD |
PMID:33626375 PMID:34416349 |
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NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
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G |
HIF1A |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HIF1A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HIF1A protein |
CTD |
PMID:33493553 |
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NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
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G |
HK2 |
hexokinase 2 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HK2 mRNA |
CTD |
PMID:34416349 |
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NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,153,835...68,231,615
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G |
HMOX1 |
heme oxygenase 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HMOX1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein |
CTD |
PMID:33493553 PMID:33592257 PMID:34416349 |
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G |
HSP90B1 |
heat shock protein 90 beta family member 1 |
multiple interactions increases expression |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSP90B1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSP90B1 protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA] |
CTD |
PMID:17464326 PMID:18086661 PMID:33891997 |
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NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
increases phosphorylation decreases response to substance decreases expression multiple interactions increases expression |
EXP |
Cadmium Chloride results in increased phosphorylation of HSPA5 protein HSPA5 results in decreased susceptibility to Cadmium Chloride Cadmium Chloride results in decreased expression of HSPA5 mRNA [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSPA5 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSPA5 protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; CAT inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein] Cadmium Chloride results in increased expression of HSPA5 mRNA; Cadmium Chloride results in increased expression of HSPA5 protein |
CTD |
PMID:16759985 PMID:17464326 PMID:18086661 PMID:20576581 PMID:20600546 PMID:33891997 More...
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NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
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HYOU1 |
hypoxia up-regulated 1 |
decreases response to substance |
EXP |
HYOU1 results in decreased susceptibility to Cadmium Chloride |
CTD |
PMID:17464326 |
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NCBI chr 9:46,264,929...46,277,056
Ensembl chr 9:46,264,933...46,276,995
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IDH2 |
isocitrate dehydrogenase (NADP(+)) 2 |
affects binding decreases activity multiple interactions affects folding decreases response to substance |
EXP |
Cadmium Chloride binds to IDH2 protein Cadmium Chloride results in decreased activity of IDH2 protein [oxalomalic acid results in decreased activity of IDH2 protein] which results in increased susceptibility to Cadmium Chloride; Dithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; IDH2 protein inhibits the reaction [Cadmium Chloride results in decreased activity of GLRX protein] Cadmium Chloride affects the folding of IDH2 protein IDH2 protein results in decreased susceptibility to Cadmium Chloride |
CTD |
PMID:16785314 |
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NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554
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IFNG |
interferon gamma |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IFNG mRNA |
CTD |
PMID:33592257 PMID:33891997 |
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NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670
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IKBKB |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IKBKB mRNA |
CTD |
PMID:33592257 |
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NCBI chr17:11,289,607...11,348,557
Ensembl chr17:11,289,690...11,348,549
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G |
IL10 |
interleukin 10 |
multiple interactions decreases expression |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA Cadmium Chloride results in decreased expression of IL10 mRNA |
CTD |
PMID:33592257 PMID:33626375 PMID:34416349 |
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NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378
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IL13 |
interleukin 13 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL13 mRNA |
CTD |
PMID:33891997 |
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NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093
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IL17A |
interleukin 17A |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL17A mRNA |
CTD |
PMID:33592257 |
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NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153
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IL18 |
interleukin 18 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL18 mRNA |
CTD |
PMID:33592257 PMID:34416349 |
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NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219
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IL1A |
interleukin 1 alpha |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1A mRNA |
CTD |
PMID:33592257 |
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NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
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G |
IL2 |
interleukin 2 |
multiple interactions increases expression |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL2 mRNA Cadmium Chloride results in increased expression of IL2 mRNA |
CTD |
PMID:33592257 PMID:33626375 |
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NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
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G |
IL4 |
interleukin 4 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL4 mRNA |
CTD |
PMID:33891997 PMID:34416349 |
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NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
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G |
IL6 |
interleukin 6 |
multiple interactions increases expression |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL6 mRNA Cadmium Chloride results in increased expression of IL6 mRNA |
CTD |
PMID:33592257 PMID:33626375 PMID:33891997 PMID:34416349 |
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NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
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IL7 |
interleukin 7 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL7 mRNA |
CTD |
PMID:33592257 |
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NCBI chr 4:57,677,895...57,744,713
Ensembl chr 4:57,684,796...57,744,709
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G |
ITPR1 |
inositol 1,4,5-trisphosphate receptor type 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ITPR1 mRNA |
CTD |
PMID:33891997 |
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NCBI chr13:61,068,131...61,398,918
Ensembl chr13:61,068,126...61,398,912
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP |
Cadmium Chloride results in increased expression of JUN mRNA [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN protein |
CTD |
PMID:7564105 PMID:33891997 |
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NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636
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G |
LDHA |
lactate dehydrogenase A |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA mRNA |
CTD |
PMID:34416349 |
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NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715
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G |
LOC110258578 |
interleukin-1 beta-like |
multiple interactions increases expression |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein Cadmium Chloride results in increased expression of IL1B mRNA |
CTD |
PMID:33592257 PMID:33626375 PMID:34416349 |
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LRP2 |
LDL receptor related protein 2 |
decreases expression multiple interactions increases degradation |
EXP |
Cadmium Chloride results in decreased expression of LRP2 mRNA; Cadmium Chloride results in decreased expression of LRP2 protein bafilomycin A inhibits the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]; Cycloheximide promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein] Cadmium Chloride results in increased degradation of LRP2 protein |
CTD |
PMID:20576581 |
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NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,303...75,716,694
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
EXP |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Selenium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; XBP1 affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:10696784 PMID:17383151 PMID:17464326 PMID:18086661 |
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NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
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G |
MAPK9 |
mitogen-activated protein kinase 9 |
multiple interactions increases phosphorylation |
EXP |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]; Selenium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:10696784 PMID:17383151 |
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NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100
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G |
MFF |
mitochondrial fission factor |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MFF mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MFF protein |
CTD |
PMID:33493553 |
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NCBI chr15:128,768,441...128,799,355
Ensembl chr15:128,768,348...128,799,344
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G |
MFN1 |
mitofusin 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN1 protein |
CTD |
PMID:33493553 PMID:33592257 |
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NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481
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G |
MFN2 |
mitofusin 2 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MFN2 protein |
CTD |
PMID:33493553 PMID:33592257 |
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NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438
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MIR125A |
microRNA mir-125a |
decreases expression multiple interactions |
EXP |
Cadmium Chloride results in decreased expression of MIR125A mRNA [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein; [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein; [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein; [Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein; Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; MIR125A mRNA inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]] |
CTD |
PMID:26607349 |
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NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645
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MLKL |
mixed lineage kinase domain like pseudokinase |
increases expression |
EXP |
Cadmium Chloride results in increased expression of MLKL mRNA; Cadmium Chloride results in increased expression of MLKL protein |
CTD |
PMID:33626375 |
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NCBI chr 6:12,923,846...12,951,176
Ensembl chr 6:12,924,894...12,951,173
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G |
MMP2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein |
CTD |
PMID:34416349 |
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NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982
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G |
MMP9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP9 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP9 protein |
CTD |
PMID:34416349 |
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NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788
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G |
MRC1 |
mannose receptor C-type 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MRC1 mRNA |
CTD |
PMID:34416349 |
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NCBI chr10:44,107,926...44,226,734
Ensembl chr10:44,107,072...44,226,733
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G |
MYC |
MYC proto-oncogene, bHLH transcription factor |
increases expression |
EXP |
Cadmium Chloride results in increased expression of MYC mRNA |
CTD |
PMID:7564105 |
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NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078
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G |
NDUFB8 |
NADH:ubiquinone oxidoreductase subunit B8 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NDUFB8 mRNA |
CTD |
PMID:34416349 |
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NCBI chr14:111,626,827...111,633,548
Ensembl chr14:111,626,097...111,633,564
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G |
NFE2 |
nuclear factor, erythroid 2 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NFE2 protein |
CTD |
PMID:33592257 |
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NCBI chr 5:19,494,672...19,501,810
Ensembl chr 5:19,494,677...19,501,810
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NFE2L2 |
NFE2 like bZIP transcription factor 2 |
decreases expression multiple interactions |
EXP |
Cadmium Chloride results in decreased expression of NFE2L2 mRNA; Cadmium Chloride results in decreased expression of NFE2L2 protein [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFE2L2 mRNA |
CTD |
PMID:33626375 PMID:34416349 |
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NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
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NFKB1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFKB1 mRNA |
CTD |
PMID:33592257 PMID:34416349 |
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NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691
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NFKBIA |
NFKB inhibitor alpha |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NFKBIA mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of and results in increased ubiquitination of NFKBIA protein |
CTD |
PMID:33592257 |
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NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277
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NKRF |
NFKB repressing factor |
increases expression |
EXP |
Cadmium Chloride results in increased expression of NKRF mRNA |
CTD |
PMID:33626375 |
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NCBI chr X:98,008,870...98,025,423
Ensembl chr X:98,007,910...98,025,373
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NLRP3 |
NLR family pyrin domain containing 3 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein |
CTD |
PMID:33592257 PMID:34416349 |
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NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228
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NOS2 |
nitric oxide synthase 2 |
increases expression multiple interactions |
EXP |
Cadmium Chloride results in increased expression of NOS2 mRNA; Cadmium Chloride results in increased expression of NOS2 protein [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOS2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOS2 protein |
CTD |
PMID:33592257 PMID:33626375 PMID:34416349 |
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NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146
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NQO1 |
NAD(P)H quinone dehydrogenase 1 |
decreases expression multiple interactions |
EXP |
Cadmium Chloride results in decreased expression of NQO1 mRNA [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NQO1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NQO1 mRNA |
CTD |
PMID:33493553 PMID:33626375 PMID:34416349 |
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NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
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G |
NRF1 |
nuclear respiratory factor 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NRF1 mRNA |
CTD |
PMID:33592257 |
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NCBI chr18:19,008,408...19,142,678
Ensembl chr18:18,998,930...19,142,628
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OPA1 |
OPA1 mitochondrial dynamin like GTPase |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OPA1 mRNA |
CTD |
PMID:33592257 |
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NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083
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G |
PARP1 |
poly(ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
EXP |
GLRX protein inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; oxalomalic acid promotes the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] |
CTD |
PMID:16785314 |
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NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196
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G |
PDK1 |
pyruvate dehydrogenase kinase 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PDK1 mRNA |
CTD |
PMID:34416349 |
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NCBI chr15:78,608,394...78,650,958
Ensembl chr15:78,608,432...78,652,962
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G |
PFKFB3 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PFKFB3 mRNA |
CTD |
PMID:34416349 |
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NCBI chr10:64,776,315...64,859,118
Ensembl chr10:64,776,315...64,802,287
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G |
PIK3CG |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PIK3CG mRNA |
CTD |
PMID:33493553 |
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NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
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G |
PMAIP1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PMAIP1 mRNA |
CTD |
PMID:33891997 |
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NCBI chr 1:161,184,458...161,188,138
Ensembl chr 1:161,182,887...161,188,164
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G |
POMC |
proopiomelanocortin |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of POMC protein |
CTD |
PMID:34416349 |
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NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418
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G |
PPARA |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PPARA mRNA |
CTD |
PMID:34416349 |
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NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239
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G |
PPARGC1A |
PPARG coactivator 1 alpha |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PPARGC1A mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PPARGC1A protein |
CTD |
PMID:33592257 |
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NCBI chr 8:17,841,844...18,527,953
Ensembl chr 8:17,841,844...17,946,992
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G |
PRKAA1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PRKAA1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAA1 mRNA |
CTD |
PMID:33592257 PMID:34416349 |
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NCBI chr16:25,745,902...25,783,524
Ensembl chr16:25,745,324...25,783,707
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G |
PRKAA2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAA2 mRNA |
CTD |
PMID:34416349 |
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NCBI chr 6:155,683,392...155,754,283
Ensembl chr 6:155,681,784...155,754,278
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G |
PRKAB1 |
protein kinase AMP-activated non-catalytic subunit beta 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAB1 mRNA |
CTD |
PMID:34416349 |
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NCBI chr14:33,201,359...33,217,641
Ensembl chr14:33,201,669...33,217,539
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G |
PRKAG1 |
protein kinase AMP-activated non-catalytic subunit gamma 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAG1 mRNA |
CTD |
PMID:34416349 |
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NCBI chr 5:15,033,051...15,049,676
Ensembl chr 5:15,033,058...15,049,735
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G |
PRKAG3 |
protein kinase AMP-activated non-catalytic subunit gamma 3 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PRKAG3 mRNA |
CTD |
PMID:34416349 |
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NCBI chr15:120,859,486...120,866,308
Ensembl chr15:120,855,201...120,866,332
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G |
PTGER3 |
prostaglandin E receptor 3 |
increases expression |
EXP |
Cadmium Chloride results in increased expression of PTGER3 mRNA |
CTD |
PMID:33626375 |
|
NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,955...142,161,286
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G |
PTGES3 |
prostaglandin E synthase 3 |
increases expression |
EXP |
Cadmium Chloride results in increased expression of PTGES3 protein |
CTD |
PMID:33626375 |
|
NCBI chr 5:22,000,335...22,022,830
Ensembl chr 5:22,000,341...22,021,660
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
EXP |
Cadmium Chloride results in increased expression of PTGS2 mRNA; Cadmium Chloride results in increased expression of PTGS2 protein [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PTGS2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PTGS2 protein |
CTD |
PMID:33592257 PMID:33626375 |
|
NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
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G |
RELA |
RELA proto-oncogene, NF-kB subunit |
affects localization multiple interactions |
EXP |
Cadmium Chloride affects the localization of RELA protein [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of RELA protein |
CTD |
PMID:23575899 PMID:34416349 |
|
NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
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G |
RIPK1 |
receptor interacting serine/threonine kinase 1 |
increases expression |
EXP |
Cadmium Chloride results in increased expression of RIPK1 mRNA; Cadmium Chloride results in increased expression of RIPK1 protein |
CTD |
PMID:33626375 |
|
NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,239...1,880,699
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G |
RIPK3 |
receptor interacting serine/threonine kinase 3 |
increases expression |
EXP |
Cadmium Chloride results in increased expression of RIPK3 mRNA; Cadmium Chloride results in increased expression of RIPK3 protein |
CTD |
PMID:33626375 |
|
NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251
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G |
SDHB |
succinate dehydrogenase complex iron sulfur subunit B |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SDHB mRNA |
CTD |
PMID:34416349 |
|
NCBI chr 6:75,648,362...75,678,111
Ensembl chr 6:75,648,215...75,678,378
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G |
SERPINE1 |
serpin family E member 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SERPINE1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SERPINE1 protein |
CTD |
PMID:34416349 |
|
NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547
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G |
SMAD2 |
SMAD family member 2 |
increases expression multiple interactions |
EXP |
Cadmium Chloride results in increased expression of SMAD2 mRNA [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SMAD2 mRNA |
CTD |
PMID:33626375 PMID:34416349 |
|
NCBI chr 1:97,415,360...97,511,388
Ensembl chr 1:97,415,716...97,511,357
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G |
SMAD3 |
SMAD family member 3 |
increases expression |
EXP |
Cadmium Chloride results in increased expression of SMAD3 mRNA |
CTD |
PMID:33626375 |
|
NCBI chr 1:164,998,457...165,124,455
Ensembl chr 1:164,998,103...165,124,449
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G |
SMAD4 |
SMAD family member 4 |
increases expression |
EXP |
Cadmium Chloride results in increased expression of SMAD4 mRNA |
CTD |
PMID:33626375 |
|
NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029
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G |
SMAD7 |
SMAD family member 7 |
decreases expression |
EXP |
Cadmium Chloride results in decreased expression of SMAD7 mRNA; Cadmium Chloride results in decreased expression of SMAD7 protein |
CTD |
PMID:33626375 |
|
NCBI chr 1:98,512,800...98,543,924
Ensembl chr 1:98,514,267...98,542,382
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G |
SOD1 |
superoxide dismutase 1 |
decreases expression multiple interactions |
EXP |
Cadmium Chloride results in decreased expression of SOD1 mRNA [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SOD1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SOD1 mRNA |
CTD |
PMID:33493553 PMID:33626375 PMID:34416349 |
|
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
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G |
SOD2 |
superoxide dismutase 2 |
decreases response to substance decreases expression multiple interactions |
EXP |
SOD2 results in decreased susceptibility to Cadmium Chloride Cadmium Chloride results in decreased expression of SOD2 mRNA [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SOD2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SOD2 mRNA; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]; SOD2 inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; SOD2 inhibits the reaction [Cadmium Chloride results in increased splicing of XBP1 mRNA] |
CTD |
PMID:18086661 PMID:33493553 PMID:33626375 PMID:34416349 |
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NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
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G |
TFAM |
transcription factor A, mitochondrial |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TFAM mRNA |
CTD |
PMID:33592257 |
|
NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,731
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G |
TGFB1 |
transforming growth factor beta 1 |
multiple interactions increases expression |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TGFB1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TGFB1 protein; Cadmium Chloride results in increased expression of and results in increased cleavage of TGFB1 protein Cadmium Chloride results in increased expression of TGFB1 mRNA; Cadmium Chloride results in increased expression of TGFB1 protein |
CTD |
PMID:33626375 PMID:34416349 |
|
NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046
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G |
TGFBR1 |
transforming growth factor beta receptor 1 |
increases expression |
EXP |
Cadmium Chloride results in increased expression of TGFBR1 mRNA |
CTD |
PMID:33626375 |
|
NCBI chr 1:240,842,735...240,918,267
Ensembl chr 1:240,860,156...240,918,528
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G |
TGFBR2 |
transforming growth factor beta receptor 2 |
increases expression |
EXP |
Cadmium Chloride results in increased expression of TGFBR2 mRNA |
CTD |
PMID:33626375 |
|
NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,490...16,878,160
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G |
TIMP1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TIMP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TIMP1 protein |
CTD |
PMID:34416349 |
|
NCBI chr X:42,103,251...42,106,289
Ensembl chr X:42,102,172...42,106,296
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G |
TIMP2 |
TIMP metallopeptidase inhibitor 2 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TIMP2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TIMP2 protein |
CTD |
PMID:34416349 |
|
NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,834
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G |
TLR4 |
toll like receptor 4 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TLR4 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TLR4 protein |
CTD |
PMID:34416349 |
|
NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970
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G |
TNF |
tumor necrosis factor |
increases expression multiple interactions |
EXP |
Cadmium Chloride results in increased expression of TNF mRNA; Cadmium Chloride results in increased expression of TNF protein [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF mRNA |
CTD |
PMID:33626375 PMID:33891997 PMID:34416349 |
|
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
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G |
TNFRSF1A |
TNF receptor superfamily member 1A |
multiple interactions increases expression |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNFRSF1A mRNA Cadmium Chloride results in increased expression of TNFRSF1A mRNA; Cadmium Chloride results in increased expression of TNFRSF1A protein |
CTD |
PMID:33592257 PMID:33626375 |
|
NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909
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G |
TRAF2 |
TNF receptor associated factor 2 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TRAF2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TRAF2 protein |
CTD |
PMID:33891997 |
|
|
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G |
TRAF6 |
TNF receptor associated factor 6 |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TRAF6 mRNA |
CTD |
PMID:33592257 |
|
NCBI chr 2:24,602,749...24,628,263
Ensembl chr 2:24,602,804...24,626,072
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G |
TWNK |
twinkle mtDNA helicase |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TWNK mRNA |
CTD |
PMID:33592257 |
|
NCBI chr14:112,068,463...112,076,169
Ensembl chr14:112,069,925...112,075,792
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G |
UQCRQ |
ubiquinol-cytochrome c reductase complex III subunit VII |
multiple interactions |
EXP |
[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of UQCRQ mRNA |
CTD |
PMID:34416349 |
|
NCBI chr 2:135,186,366...135,188,237
Ensembl chr 2:135,186,501...135,188,293
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G |
XBP1 |
X-box binding protein 1 |
increases splicing multiple interactions |
EXP |
Cadmium Chloride results in increased splicing of XBP1 mRNA [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of XBP1 mRNA alternative form; SOD2 inhibits the reaction [Cadmium Chloride results in increased splicing of XBP1 mRNA]; XBP1 affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:17464326 PMID:18086661 PMID:33891997 |
|
NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526
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G |
CD14 |
CD14 molecule |
affects expression |
EXP |
cadmium nitrate affects the expression of CD14 mRNA |
CTD |
PMID:29421334 |
|
NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581
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G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
affects expression affects secretion |
EXP |
cadmium nitrate affects the expression of CXCL8 mRNA cadmium nitrate affects the secretion of CXCL8 protein |
CTD |
PMID:29421334 |
|
NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
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G |
DEFB1 |
defensin beta 1 |
increases expression |
EXP |
cadmium nitrate results in increased expression of DEFB1 mRNA |
CTD |
PMID:29421334 |
|
|
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G |
IFNB1 |
interferon beta 1 |
increases expression |
EXP |
cadmium nitrate results in increased expression of IFNB1 mRNA |
CTD |
PMID:29421334 |
|
NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495
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G |
IL18 |
interleukin 18 |
increases expression |
EXP |
cadmium nitrate results in increased expression of IL18 mRNA |
CTD |
PMID:29421334 |
|
NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219
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G |
IL6 |
interleukin 6 |
increases expression |
EXP |
cadmium nitrate results in increased expression of IL6 mRNA |
CTD |
PMID:29421334 |
|
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
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G |
LOC110258578 |
interleukin-1 beta-like |
increases expression |
EXP |
cadmium nitrate results in increased expression of IL1B mRNA |
CTD |
PMID:29421334 |
|
|
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G |
MAPK14 |
mitogen-activated protein kinase 14 |
affects expression |
EXP |
cadmium nitrate affects the expression of MAPK14 mRNA |
CTD |
PMID:29421334 |
|
NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
increases expression |
EXP |
cadmium nitrate results in increased expression of MAPK8 mRNA |
CTD |
PMID:29421334 |
|
NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
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G |
MYD88 |
MYD88 innate immune signal transduction adaptor |
affects expression |
EXP |
cadmium nitrate affects the expression of MYD88 mRNA |
CTD |
PMID:29421334 |
|
NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109
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G |
NFKB1 |
nuclear factor kappa B subunit 1 |
affects expression |
EXP |
cadmium nitrate affects the expression of NFKB1 mRNA |
CTD |
PMID:29421334 |
|
NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691
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G |
RELA |
RELA proto-oncogene, NF-kB subunit |
increases expression |
EXP |
cadmium nitrate results in increased expression of RELA mRNA |
CTD |
PMID:29421334 |
|
NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
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G |
SOCS1 |
suppressor of cytokine signaling 1 |
decreases expression |
EXP |
cadmium nitrate results in decreased expression of SOCS1 mRNA |
CTD |
PMID:29421334 |
|
NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,967
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G |
STAT3 |
signal transducer and activator of transcription 3 |
decreases expression |
EXP |
cadmium nitrate results in decreased expression of STAT3 mRNA |
CTD |
PMID:29421334 |
|
NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992
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G |
TLR4 |
toll like receptor 4 |
affects expression |
EXP |
cadmium nitrate affects the expression of TLR4 mRNA |
CTD |
PMID:29421334 |
|
NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970
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G |
TLR5 |
toll like receptor 5 |
increases expression |
EXP |
cadmium nitrate results in increased expression of TLR5 mRNA |
CTD |
PMID:29421334 |
|
NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024
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G |
TNF |
tumor necrosis factor |
increases expression |
EXP |
cadmium nitrate results in increased expression of TNF mRNA |
CTD |
PMID:29421334 |
|
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
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G |
CASP3 |
caspase 3 |
decreases activity |
EXP |
cadmium selenide results in decreased activity of CASP3 protein |
CTD |
PMID:18632727 |
|
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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G |
ABCB1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
multiple interactions |
EXP |
Cisplatin inhibits the reaction [ABCB1 protein results in increased susceptibility to NSC73306] |
CTD |
PMID:24800945 |
|
NCBI chr 9:93,049,955...93,146,469
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G |
AIFM1 |
apoptosis inducing factor mitochondria associated 1 |
affects response to substance |
EXP |
AIFM1 protein affects the susceptibility to Cisplatin |
CTD |
PMID:15983031 |
|
NCBI chr X:106,676,596...106,708,290
Ensembl chr X:106,670,520...106,708,317
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G |
BAX |
BCL2 associated X, apoptosis regulator |
multiple interactions affects localization |
EXP |
Bezafibrate inhibits the reaction [Cisplatin affects the localization of BAX protein] |
CTD |
PMID:16316343 |
|
NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
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G |
CASP2 |
caspase 2 |
increases expression |
EXP |
Cisplatin results in increased expression of CASP2 |
CTD |
PMID:12712633 |
|
NCBI chr18:6,946,432...6,966,088
Ensembl chr18:6,941,937...6,966,061
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G |
CASP3 |
caspase 3 |
increases expression multiple interactions increases activity |
EXP |
Cisplatin results in increased expression of CASP3 [Cisplatin co-treated with EPO protein] results in increased cleavage of CASP3 protein; Bezafibrate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:12712633 PMID:16316343 PMID:20435919 PMID:21497595 |
|
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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G |
CASP8 |
caspase 8 |
increases activity increases expression multiple interactions |
EXP |
Cisplatin results in increased activity of CASP8 protein Cisplatin results in increased expression of CASP8 Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein] |
CTD |
PMID:12712633 PMID:20435919 |
|
NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
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G |
CASP9 |
caspase 9 |
increases expression increases activity |
EXP |
Cisplatin results in increased expression of CASP9 Cisplatin results in increased activity of CASP9 protein |
CTD |
PMID:12712633 PMID:20435919 |
|
NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
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G |
CYCS |
cytochrome c, somatic |
affects localization multiple interactions |
EXP |
Cisplatin affects the localization of CYCS protein Bezafibrate inhibits the reaction [Cisplatin affects the localization of CYCS protein] |
CTD |
PMID:16316343 |
|
NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
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G |
EPO |
erythropoietin |
multiple interactions |
EXP |
[Cisplatin co-treated with EPO protein] results in increased cleavage of CASP3 protein |
CTD |
PMID:21497595 |
|
NCBI chr 3:8,620,508...8,622,936
Ensembl chr 3:8,620,508...8,622,936
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G |
FAS |
Fas cell surface death receptor |
increases expression |
EXP |
Cisplatin results in increased expression of FAS mRNA |
CTD |
PMID:20435919 |
|
NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716
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G |
FASLG |
Fas ligand |
multiple interactions affects localization |
EXP |
Cilastatin inhibits the reaction [Cisplatin affects the localization of FASLG protein] |
CTD |
PMID:20435919 |
|
NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464
|
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G |
GCLC |
glutamate-cysteine ligase catalytic subunit |
multiple interactions |
EXP |
Buthionine Sulfoximine inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein] |
CTD |
PMID:20732396 |
|
NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
|
|
G |
MYC |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions increases expression |
EXP |
Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of MYC] |
CTD |
PMID:12712633 |
|
NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078
|
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G |
NQO1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
EXP |
Dicumarol inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein] |
CTD |
PMID:20732396 |
|
NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
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G |
PARP1 |
poly(ADP-ribose) polymerase 1 |
increases activity multiple interactions |
EXP |
Cisplatin results in increased activity of PARP1 protein N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Cisplatin results in increased activity of PARP1 protein] |
CTD |
PMID:25806124 |
|
NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196
|
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G |
PPARA |
peroxisome proliferator activated receptor alpha |
decreases activity multiple interactions |
EXP |
Cisplatin results in decreased activity of PPARA protein [Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified; Bezafibrate inhibits the reaction [[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified]; Bezafibrate inhibits the reaction [Cisplatin results in decreased activity of PPARA protein] |
CTD |
PMID:16316343 |
|
NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239
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G |
TNF |
tumor necrosis factor |
increases expression |
EXP |
Cisplatin results in increased expression of TNF mRNA |
CTD |
PMID:20435919 |
|
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
|
|
G |
TP53 |
tumor protein p53 |
increases expression multiple interactions |
EXP |
Cisplatin results in increased expression of TP53 mangostin inhibits the reaction [Cisplatin results in increased expression of TP53] |
CTD |
PMID:12712633 PMID:20603111 |
|
NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
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G |
AOC1 |
amine oxidase copper containing 1 |
affects binding |
EXP |
cobaltous chloride binds to AOC1 protein |
CTD |
PMID:16842785 |
|
NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974
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G |
HSP90B1 |
heat shock protein 90 beta family member 1 |
increases expression |
EXP |
cobaltous chloride results in increased expression of HSP90B1 mRNA |
CTD |
PMID:17464326 |
|
NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
EXP |
cobaltous chloride results in increased expression of HSPA5 mRNA |
CTD |
PMID:17464326 |
|
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
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G |
ATP7B |
ATPase copper transporting beta |
multiple interactions affects binding |
EXP |
Cholera Toxin inhibits the reaction [Copper binds to ATP7B protein]; Colforsin inhibits the reaction [Copper binds to ATP7B protein]; Cyclic AMP inhibits the reaction [Copper binds to ATP7B protein]; PRKACA protein inhibits the reaction [Copper binds to ATP7B protein] |
CTD |
PMID:21084060 |
|
NCBI chr11:15,892,549...15,942,070
Ensembl chr11:15,876,612...15,942,064
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G |
GNRH1 |
gonadotropin releasing hormone 1 |
affects binding multiple interactions |
EXP |
Copper binds to GNRH1 protein [Copper binds to GNRH1 protein] which results in increased secretion of LHB protein |
CTD |
PMID:16892001 |
|
NCBI chr14:9,442,971...9,447,521
Ensembl chr14:9,442,971...9,453,035
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G |
IGF1 |
insulin like growth factor 1 |
increases expression |
EXP |
Copper results in increased expression of IGF1 mRNA |
CTD |
PMID:22367704 |
|
NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033
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G |
LHB |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
[Copper binds to GNRH1 protein] which results in increased secretion of LHB protein |
CTD |
PMID:16892001 |
|
NCBI chr 6:54,263,574...54,269,286
Ensembl chr 6:54,263,576...54,271,086
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G |
PRKACA |
protein kinase cAMP-activated catalytic subunit alpha |
multiple interactions |
EXP |
PRKACA protein inhibits the reaction [Copper binds to ATP7B protein] |
CTD |
PMID:21084060 |
|
NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,551
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G |
AOC1 |
amine oxidase copper containing 1 |
increases activity |
EXP |
cupric chloride results in increased activity of AOC1 protein |
CTD |
PMID:16842785 |
|
NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974
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G |
ATOX1 |
antioxidant 1 copper chaperone |
increases expression |
EXP |
Copper Sulfate results in increased expression of ATOX1 mRNA |
CTD |
PMID:22585802 |
|
NCBI chr16:71,299,321...71,314,598
Ensembl chr16:71,299,321...71,314,597
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G |
CCNB1 |
cyclin B1 |
increases secretion |
EXP |
Copper Sulfate results in increased secretion of CCNB1 protein |
CTD |
PMID:24521407 |
|
NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377
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G |
COX17 |
cytochrome c oxidase copper chaperone COX17 |
decreases expression |
EXP |
Copper Sulfate results in decreased expression of COX17 mRNA |
CTD |
PMID:22585802 |
|
NCBI chr13:140,584,286...140,594,636
Ensembl chr13:140,584,363...140,587,621
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G |
GHRH |
growth hormone releasing hormone |
increases expression |
EXP |
Copper Sulfate results in increased expression of GHRH mRNA |
CTD |
PMID:21110139 |
|
NCBI chr17:40,386,725...40,398,312
Ensembl chr17:40,387,344...40,397,857
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G |
HSP90B1 |
heat shock protein 90 beta family member 1 |
increases expression |
EXP |
Copper Sulfate results in increased expression of HSP90B1 mRNA |
CTD |
PMID:17464326 |
|
NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
EXP |
Copper Sulfate results in increased expression of HSPA5 mRNA |
CTD |
PMID:17464326 |
|
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
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G |
IGF1 |
insulin like growth factor 1 |
increases secretion |
EXP |
Copper Sulfate results in increased secretion of IGF1 protein |
CTD |
PMID:24521407 |
|
NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033
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G |
SST |
somatostatin |
decreases expression |
EXP |
Copper Sulfate results in decreased expression of SST mRNA; Copper Sulfate results in decreased expression of SST protein |
CTD |
PMID:21110139 |
|
NCBI chr13:125,337,560...125,338,742
Ensembl chr13:125,337,418...125,338,850
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G |
CAT |
catalase |
multiple interactions |
EXP |
[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein |
CTD |
PMID:29129240 |
|
NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
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G |
DNMT1 |
DNA methyltransferase 1 |
multiple interactions |
EXP |
[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA |
CTD |
PMID:28445388 |
|
NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844
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G |
DNMT3A |
DNA methyltransferase 3 alpha |
multiple interactions |
EXP |
[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA |
CTD |
PMID:28445388 |
|
NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087
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G |
GPX1 |
glutathione peroxidase 1 |
multiple interactions |
EXP |
[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA |
CTD |
PMID:29129240 |
|
NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
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G |
MTHFR |
methylenetetrahydrofolate reductase |
multiple interactions |
EXP |
[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA |
CTD |
PMID:28445388 |
|
NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820
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G |
SI |
sucrase-isomaltase |
multiple interactions |
EXP |
[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA |
CTD |
PMID:28445388 |
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NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
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G |
SLC15A1 |
solute carrier family 15 member 1 |
multiple interactions |
EXP |
[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA |
CTD |
PMID:28445388 |
|
NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
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G |
SLC5A1 |
solute carrier family 5 member 1 |
multiple interactions |
EXP |
[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA |
CTD |
PMID:28445388 |
|
NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841
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G |
SOD1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA |
CTD |
PMID:29129240 |
|
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
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G |
HMOX1 |
heme oxygenase 1 |
increases metabolic processing multiple interactions |
EXP |
HMOX1 protein results in increased metabolism of Heme [HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide; chromium mesoporphyrin inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]; tin protoporphyrin IX inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide] |
CTD |
PMID:16751286 |
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G |
HMOX1 |
heme oxygenase 1 |
increases metabolic processing multiple interactions |
EXP |
HMOX1 protein results in increased metabolism of Heme [HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide; chromium mesoporphyrin inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]; tin protoporphyrin IX inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide] |
CTD |
PMID:16751286 |
|
|
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G |
FBP1 |
fructose-bisphosphatase 1 |
increases activity |
EXP |
Manganese results in increased activity of FBP1 protein |
CTD |
PMID:12595529 |
|
NCBI chr10:27,588,609...27,622,225
Ensembl chr10:27,588,570...27,622,674
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G |
OGDH |
oxoglutarate dehydrogenase |
multiple interactions |
EXP |
Manganese inhibits the reaction [Calcium results in increased activity of OGDH protein] |
CTD |
PMID:20800605 |
|
NCBI chr18:50,609,415...50,684,990
Ensembl chr18:50,609,418...50,684,964
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G |
AQP1 |
aquaporin 1 (Colton blood group) |
multiple interactions |
EXP |
Mercuric Chloride inhibits the reaction [AQP1 protein results in increased transport of Water] |
CTD |
PMID:16534851 |
|
NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,485...42,076,746
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G |
ATF4 |
activating transcription factor 4 |
increases expression |
EXP |
Mercuric Chloride results in increased expression of ATF4 protein |
CTD |
PMID:16759985 |
|
NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
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G |
EIF2A |
eukaryotic translation initiation factor 2A |
increases phosphorylation |
EXP |
Mercuric Chloride results in increased phosphorylation of EIF2A protein |
CTD |
PMID:16759985 |
|
NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,274
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G |
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
EXP |
Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of FOS mRNA] Mercuric Chloride results in increased expression of FOS mRNA; Mercuric Chloride results in increased expression of FOS protein |
CTD |
PMID:9463523 |
|
NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
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G |
HSP90B1 |
heat shock protein 90 beta family member 1 |
increases expression |
EXP |
Mercuric Chloride results in increased expression of HSP90B1 mRNA |
CTD |
PMID:17464326 |
|
NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
EXP |
Mercuric Chloride results in increased expression of HSPA5 mRNA |
CTD |
PMID:17464326 |
|
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression increases phosphorylation |
EXP |
Mercuric Chloride results in increased expression of JUN mRNA; Mercuric Chloride results in increased expression of JUN protein Mercuric Chloride results in increased phosphorylation of JUN protein |
CTD |
PMID:10696784 |
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NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
increases phosphorylation |
EXP |
Mercuric Chloride results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:10696784 |
|
NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
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G |
MAPK9 |
mitogen-activated protein kinase 9 |
increases phosphorylation |
EXP |
Mercuric Chloride results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:10696784 |
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NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100
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G |
ATF4 |
activating transcription factor 4 |
increases expression |
EXP |
Mercury results in increased expression of ATF4 protein |
CTD |
PMID:16759985 |
|
NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
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G |
EIF2A |
eukaryotic translation initiation factor 2A |
increases phosphorylation |
EXP |
Mercury results in increased phosphorylation of EIF2A protein |
CTD |
PMID:16759985 |
|
NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,274
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G |
FSHB |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
[FSHB protein co-treated with Lead co-treated with Mercury] results in decreased secretion of Progesterone |
CTD |
PMID:20390873 |
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NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
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G |
LDHA |
lactate dehydrogenase A |
multiple interactions |
EXP |
Mercury binds to and results in decreased folding of LDHA protein |
CTD |
PMID:18501191 |
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NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715
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G |
GAPDH |
glyceraldehyde-3-phosphate dehydrogenase |
decreases activity |
EXP |
potassium chromate(VI) results in decreased activity of GAPDH protein |
CTD |
PMID:26582256 |
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NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991
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G |
NOS3 |
nitric oxide synthase 3 |
decreases activity |
EXP |
potassium ferricyanide results in decreased activity of NOS3 protein |
CTD |
PMID:8810647 |
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NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
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G |
TRPV1 |
transient receptor potential cation channel subfamily V member 1 |
multiple interactions |
EXP |
Ruthenium Red inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]] |
CTD |
PMID:18230619 |
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NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,713,977
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G |
AKT1 |
AKT serine/threonine kinase 1 |
decreases expression |
EXP |
sodium bichromate results in decreased expression of AKT1 protein |
CTD |
PMID:12760830 |
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G |
AKT1 |
AKT serine/threonine kinase 1 |
increases phosphorylation |
EXP |
titanium dioxide results in increased phosphorylation of AKT1 protein |
CTD |
PMID:23380242 |
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G |
CCL2 |
chemokine (C-C motif) ligand 2 |
multiple interactions increases expression |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; prolinedithiocarbamate inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA] |
CTD |
PMID:23380242 |
|
NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
increases phosphorylation |
EXP |
titanium dioxide results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:23380242 |
|
NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
increases phosphorylation |
EXP |
titanium dioxide results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:23380242 |
|
NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
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G |
NFKBIA |
NFKB inhibitor alpha |
increases phosphorylation |
EXP |
titanium dioxide results in increased phosphorylation of NFKBIA protein |
CTD |
PMID:23380242 |
|
NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277
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G |
VCAM1 |
vascular cell adhesion molecule 1 |
increases expression multiple interactions |
EXP |
titanium dioxide results in increased expression of VCAM1 mRNA; titanium dioxide results in increased expression of VCAM1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]; acetovanillone inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]; prolinedithiocarbamate inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]; pyrazolanthrone inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]; SB 203580 inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA] |
CTD |
PMID:23380242 |
|
NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
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G |
INS |
insulin |
decreases expression |
EXP |
chromium tripicolinate results in decreased expression of INS protein |
CTD |
PMID:7628956 |
|
NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
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G |
ANXA5 |
annexin A5 |
multiple interactions |
EXP |
Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]] |
CTD |
PMID:10617950 |
|
NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750
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G |
CASP3 |
caspase 3 |
multiple interactions |
EXP |
Zinc Acetate inhibits the reaction [Linoleic Acid results in increased activity of CASP3 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]] |
CTD |
PMID:10617950 |
|
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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G |
PPARA |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA] |
CTD |
PMID:18845708 |
|
NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA] |
CTD |
PMID:18845708 |
|
NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
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G |
SELE |
selectin E |
multiple interactions |
EXP |
Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SELE mRNA] |
CTD |
PMID:18845708 |
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NCBI chr 4:81,289,061...81,299,657
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G |
TNF |
tumor necrosis factor |
multiple interactions |
EXP |
Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]] |
CTD |
PMID:10617950 |
|
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
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G |
PSP-I |
porcine seminal protein I |
multiple interactions affects folding |
EXP |
zinc chloride promotes the reaction [PSP-I protein binds to Heparin] zinc chloride affects the folding of PSP-I protein |
CTD |
PMID:16819821 |
|
NCBI chr14:132,302,376...132,309,388
Ensembl chr14:132,302,352...132,308,106
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G |
AMY2 |
amylase, alpha 2B (pancreatic) |
increases activity |
EXP |
Zinc Oxide results in increased activity of AMY2B protein |
CTD |
PMID:17093223 |
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NCBI chr 4:115,172,036...115,209,749
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G |
CPA1 |
carboxypeptidase A1 |
increases activity |
EXP |
Zinc Oxide results in increased activity of CPA1 protein |
CTD |
PMID:17093223 |
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NCBI chr18:18,466,564...18,482,099
Ensembl chr18:18,469,921...18,476,327
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G |
IGF1 |
insulin like growth factor 1 |
increases expression |
EXP |
Zinc Oxide results in increased expression of IGF1 mRNA |
CTD |
PMID:7899834 |
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NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033
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G |
LOC100302368 |
trypsinogen |
increases activity |
EXP |
Zinc Oxide results in increased activity of PRSS1 protein |
CTD |
PMID:17093223 |
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NCBI chr18:7,653,537...7,696,820
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G |
GUCY1B1 |
guanylate cyclase 1 soluble subunit beta 1 |
multiple interactions |
EXP |
zinc protoporphyrin inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein] |
CTD |
PMID:19466990 |
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NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687
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G |
BAX |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
EXP |
Zinc Sulfate results in increased expression of BAX mRNA 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA] |
CTD |
PMID:28803810 |
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NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
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G |
BECN1 |
beclin 1 |
increases expression multiple interactions |
EXP |
Zinc Sulfate results in increased expression of BECN1 protein 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein] |
CTD |
PMID:28803810 |
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NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
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G |
CASP3 |
caspase 3 |
multiple interactions increases expression increases cleavage |
EXP |
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein] Zinc Sulfate results in increased expression of CASP3 mRNA |
CTD |
PMID:28803810 |
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NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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G |
CASP6 |
caspase 6 |
increases expression |
EXP |
Zinc Sulfate results in increased expression of CASP6 mRNA |
CTD |
PMID:28803810 |
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NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,520,629...112,537,045
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G |
CASP8 |
caspase 8 |
multiple interactions increases cleavage |
EXP |
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein] |
CTD |
PMID:28803810 |
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NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
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G |
CYCS |
cytochrome c, somatic |
increases expression multiple interactions |
EXP |
Zinc Sulfate results in increased expression of CYCS mRNA 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA] |
CTD |
PMID:28803810 |
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NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
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G |
GPX1 |
glutathione peroxidase 1 |
multiple interactions |
EXP |
Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA] |
CTD |
PMID:32280687 |
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NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
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G |
LOC110258578 |
interleukin-1 beta-like |
multiple interactions |
EXP |
Zinc Sulfate inhibits the reaction [Diquat results in increased expression of IL1B mRNA] |
CTD |
PMID:32280687 |
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G |
MAP1LC3A |
microtubule associated protein 1 light chain 3 alpha |
increases expression |
EXP |
Zinc Sulfate results in increased expression of MAP1LC3A mRNA |
CTD |
PMID:28803810 |
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NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505
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G |
MT1A |
metallothionein 1A |
increases expression |
EXP |
Zinc Sulfate results in increased expression of MT1A mRNA |
CTD |
PMID:25895165 |
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NCBI chr 6:18,672,016...18,673,673
Ensembl chr 6:18,672,001...18,673,672
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G |
NFE2L2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA] |
CTD |
PMID:32280687 |
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NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
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G |
SLC30A1 |
solute carrier family 30 member 1 |
increases expression |
EXP |
Zinc Sulfate results in increased expression of SLC30A1 mRNA |
CTD |
PMID:25895165 |
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NCBI chr 9:131,633,586...131,636,934
Ensembl chr 9:131,633,585...131,640,672
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G |
SLC39A10 |
solute carrier family 39 member 10 |
decreases expression increases expression |
EXP |
Zinc Sulfate results in decreased expression of SLC39A10 mRNA Zinc Sulfate results in increased expression of SLC39A10 mRNA |
CTD |
PMID:16804107 |
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NCBI chr15:99,584,830...99,724,621
Ensembl chr15:99,584,872...99,724,611
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G |
SOD1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA] |
CTD |
PMID:32280687 |
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NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
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G |
SQSTM1 |
sequestosome 1 |
increases expression multiple interactions decreases expression |
EXP |
Zinc Sulfate results in increased expression of SQSTM1 mRNA 3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein] |
CTD |
PMID:28803810 |
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NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938
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G |
TNF |
tumor necrosis factor |
multiple interactions |
EXP |
Zinc Sulfate inhibits the reaction [Diquat results in increased expression of TNF mRNA] |
CTD |
PMID:32280687 |
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NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
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G |
AMY2 |
amylase, alpha 2B (pancreatic) |
increases activity |
EXP |
Zinc results in increased activity of AMY2B protein |
CTD |
PMID:17093223 |
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NCBI chr 4:115,172,036...115,209,749
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G |
BAX |
BCL2 associated X, apoptosis regulator |
increases expression |
EXP |
Zinc results in increased expression of BAX protein |
CTD |
PMID:11781163 |
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NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
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G |
BCL2 |
BCL2 apoptosis regulator |
increases expression |
EXP |
Zinc results in increased expression of BCL2 protein |
CTD |
PMID:11781163 |
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NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
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G |
BCL2L1 |
BCL2 like 1 |
increases expression |
EXP |
Zinc results in increased expression of BCL2L1 protein |
CTD |
PMID:11781163 |
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NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694
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G |
CAT |
catalase |
multiple interactions |
EXP |
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of CAT mRNA] |
CTD |
PMID:32280687 |
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NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
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G |
CPA1 |
carboxypeptidase A1 |
increases activity |
EXP |
Zinc results in increased activity of CPA1 protein |
CTD |
PMID:17093223 |
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NCBI chr18:18,466,564...18,482,099
Ensembl chr18:18,469,921...18,476,327
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G |
FBP1 |
fructose-bisphosphatase 1 |
increases activity |
EXP |
Zinc results in increased activity of FBP1 protein |
CTD |
PMID:12595529 |
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NCBI chr10:27,588,609...27,622,225
Ensembl chr10:27,588,570...27,622,674
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G |
GPX1 |
glutathione peroxidase 1 |
multiple interactions |
EXP |
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA] |
CTD |
PMID:32280687 |
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NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
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G |
IGF1 |
insulin like growth factor 1 |
increases expression |
EXP |
Zinc results in increased expression of IGF1 protein |
CTD |
PMID:15387849 |
|
NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033
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G |
IL6 |
interleukin 6 |
multiple interactions |
EXP |
[Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL6 protein] |
CTD |
PMID:14519784 PMID:15226458 |
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NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
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G |
LOC100302368 |
trypsinogen |
increases activity |
EXP |
Zinc results in increased activity of PRSS1 protein |
CTD |
PMID:17093223 |
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NCBI chr18:7,653,537...7,696,820
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G |
LOC110258578 |
interleukin-1 beta-like |
multiple interactions |
EXP |
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of IL1B mRNA] |
CTD |
PMID:32280687 |
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G |
LTA4H |
leukotriene A4 hydrolase |
decreases activity |
EXP |
Zinc results in decreased activity of LTA4H protein |
CTD |
PMID:21670530 |
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NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515
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G |
MT3 |
metallothionein 3 |
multiple interactions |
EXP |
MT3 protein binds to and affects the abundance of Zinc |
CTD |
PMID:12405537 |
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NCBI chr 6:18,634,735...18,636,134
Ensembl chr 6:18,634,261...18,636,131
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G |
NFE2L2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA] |
CTD |
PMID:32280687 |
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NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
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G |
PPARG |
peroxisome proliferator activated receptor gamma |
multiple interactions increases expression |
EXP |
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of and results in increased activity of PPARG protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of PPARG mRNA]; Zinc results in increased expression of and results in increased activity of PPARG protein |
CTD |
PMID:14519784 |
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NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
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G |
PSP-I |
porcine seminal protein I |
multiple interactions affects folding |
EXP |
Zinc promotes the reaction [PSP-I protein binds to Heparin] Zinc affects the folding of PSP-I protein |
CTD |
PMID:16819821 |
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NCBI chr14:132,302,376...132,309,388
Ensembl chr14:132,302,352...132,308,106
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G |
SLC30A1 |
solute carrier family 30 member 1 |
increases expression |
EXP |
Zinc results in increased expression of SLC30A1 mRNA; Zinc results in increased expression of SLC30A1 protein |
CTD |
PMID:18061429 |
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NCBI chr 9:131,633,586...131,636,934
Ensembl chr 9:131,633,585...131,640,672
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G |
SLC30A2 |
solute carrier family 30 member 2 |
increases expression |
EXP |
Zinc results in increased expression of SLC30A2 protein |
CTD |
PMID:18061429 |
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NCBI chr 6:83,478,761...83,484,876
Ensembl chr 6:83,477,759...83,484,688
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G |
SLC39A10 |
solute carrier family 39 member 10 |
increases expression decreases expression |
EXP |
Zinc results in increased expression of SLC39A10 mRNA Zinc results in decreased expression of SLC39A10 mRNA |
CTD |
PMID:16804107 |
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NCBI chr15:99,584,830...99,724,621
Ensembl chr15:99,584,872...99,724,611
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G |
SOD1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA] |
CTD |
PMID:32280687 |
|
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
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G |
TNF |
tumor necrosis factor |
multiple interactions |
EXP |
[2,4-thiazolidinedione co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [ciprofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Fenofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Troglitazone co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of TNF mRNA]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]] |
CTD |
PMID:15226458 PMID:32280687 |
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NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
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G |
VCAM1 |
vascular cell adhesion molecule 1 |
multiple interactions |
EXP |
[Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]] |
CTD |
PMID:15226458 |
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NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
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