nitrogen oxoanion - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	nitrogen oxoanion	go back to main search page
Accession:	CHEBI:33458	browse the term
Synonyms:	related_synonym:	nitrogen oxoanions; oxoanions of nitrogen

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Rat (378) Mouse (374) Human (384) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (17) Green Monkey (0) Naked Mole-rat (0) All
Genes (378)

ammonium nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 1 beta

increases expression

ammonium nitrate results in increased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

cadmium nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

[cadmium nitrate results in increased abundance of Cadmium] which results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[cadmium nitrate results in increased abundance of Cadmium] which results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caveolin 1

decreases expression

cadmium nitrate results in decreased expression of CAV1 protein

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

glucose-6-phosphate dehydrogenase

decreases activity

cadmium nitrate results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

integrin subunit beta 4

decreases expression

cadmium nitrate results in decreased expression of ITGB4 protein

NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012

chromium trinitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-HS-glycoprotein

decreases expression

chromium nitrate results in decreased expression of AHSG protein

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

aldehyde dehydrogenase 1 family, member L2

increases expression

chromium nitrate results in increased expression of ALDH1L2 protein

NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776

G

amyloid P component, serum

increases expression

chromium nitrate results in increased expression of APCS protein

NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298

G

apolipoprotein A1

decreases expression

chromium nitrate results in decreased expression of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

ATP synthase F1 subunit beta

increases expression

chromium nitrate results in increased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

branched chain keto acid dehydrogenase E1 subunit beta

decreases expression

chromium nitrate results in decreased expression of BCKDHB protein

NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812

G

chaperonin containing TCP1 subunit 5

decreases expression

chromium nitrate results in decreased expression of CCT5 protein

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

carboxylesterase 1D

increases expression

chromium nitrate results in increased expression of CES1D protein

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

dihydrolipoamide branched chain transacylase E2

increases expression

chromium nitrate results in increased expression of DBT protein

NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609

G

dimethylarginine dimethylaminohydrolase 1

decreases expression

chromium nitrate results in decreased expression of DDAH1 protein

NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339

G

enoyl-CoA hydratase 1

increases expression

chromium nitrate results in increased expression of ECH1 protein

NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795

G

fructose-bisphosphatase 1

increases expression

chromium nitrate results in increased expression of FBP1 protein

NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071

G

fibrinogen beta chain

increases expression

chromium nitrate results in increased expression of FGB protein

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

G

fibrinogen gamma chain

increases expression

chromium nitrate results in increased expression of FGG protein

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

fukutin related protein

increases expression

chromium nitrate results in increased expression of FKRP protein

NCBI chr 1:77,479,641...77,486,954
Ensembl chr 1:77,476,084...77,486,992

G

GC, vitamin D binding protein

decreases expression

chromium nitrate results in decreased expression of GC protein

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

G

glutamate-cysteine ligase, catalytic subunit

increases expression

chromium nitrate results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

3-hydroxyanthranilate 3,4-dioxygenase

increases expression

chromium nitrate results in increased expression of HAAO protein

NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877

G

2-hydroxyacyl-CoA lyase 1

increases expression

chromium nitrate results in increased expression of HACL1 protein

NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027

G

3-hydroxyisobutyrate dehydrogenase

increases expression

chromium nitrate results in increased expression of HIBADH protein

NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617

G

heme oxygenase 1

increases expression

chromium nitrate results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family D (Hsp60) member 1

increases expression

chromium nitrate results in increased expression of HSPD1 protein

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

ketohexokinase

decreases expression

chromium nitrate results in decreased expression of KHK protein

NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717

G

kininogen 1

increases expression

chromium nitrate results in increased expression of KNG1 protein

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

keratin 10

increases expression

chromium nitrate results in increased expression of KRT10 protein

NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701

G

keratin 16

increases expression

chromium nitrate results in increased expression of KRT16 protein

NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799

G

keratin 17

increases expression

chromium nitrate results in increased expression of KRT17 protein

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392

G

keratin 18

decreases expression

chromium nitrate results in decreased expression of KRT18 protein

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166

G

keratin 25

increases expression

chromium nitrate results in increased expression of KRT25 protein

NCBI chr10:84,267,399...84,275,025
Ensembl chr10:84,267,399...84,274,965

G

keratin 27

increases expression

chromium nitrate results in increased expression of KRT27 protein

NCBI chr10:84,298,684...84,303,967
Ensembl chr10:84,298,508...84,303,967

G

malate dehydrogenase 1

increases expression

chromium nitrate results in increased expression of MDH1 protein

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

G

metallothionein 2A

increases expression

chromium nitrate results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

Parkinsonism associated deglycase

increases expression

chromium nitrate results in increased expression of PARK7 protein

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

propionyl-CoA carboxylase subunit alpha

increases expression

chromium nitrate results in increased expression of PCCA protein

NCBI chr15:99,627,955...99,969,555
Ensembl chr15:99,627,982...99,968,266

G

pyruvate dehydrogenase E1 subunit beta

decreases expression

chromium nitrate results in decreased expression of PDHB protein

NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500

G

prohibitin 1

decreases expression

chromium nitrate results in decreased expression of PHB1 protein

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

regucalcin

decreases expression

chromium nitrate results in decreased expression of RGN protein

NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450

G

ribosomal protein lateral stalk subunit P0

decreases expression

chromium nitrate results in decreased expression of RPLP0 protein

NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632

G

serpin family C member 1

decreases expression

chromium nitrate results in decreased expression of SERPINC1 protein

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

succinate-CoA ligase GDP-forming subunit beta

decreases expression

chromium nitrate results in decreased expression of SUCLG2 protein

NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170

G

triokinase and FMN cyclase

increases expression

chromium nitrate results in increased expression of TKFC protein

NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737

G

ubiquinol-cytochrome c reductase core protein 1

decreases expression

chromium nitrate results in decreased expression of UQCRC1 protein

NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480

G

valosin-containing protein

decreases expression

chromium nitrate results in decreased expression of VCP protein

NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571

copper(II) nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein; [copper(II) nitrate binds to 5-methyl-1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein; resveratrol inhibits the reaction [[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein]; resveratrol inhibits the reaction [[copper(II) nitrate binds to 5-methyl-1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA; [copper(II) nitrate binds to 5-methyl-1,10-phenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA; [copper(II) nitrate binds to bathophenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

interleukin 2

decreases secretion

copper(II) nitrate results in decreased secretion of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

gallium nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 7

decreases expression

gallium nitrate results in decreased expression of ABCB7 mRNA

NCBI chr X:69,295,598...69,436,775
Ensembl chr X:69,295,552...69,436,858

G

aconitase 1

increases expression

gallium nitrate results in increased expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

albumin

multiple interactions

gallium nitrate inhibits the reaction [Tamoxifen results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

beta-2 microglobulin

decreases expression

gallium nitrate results in decreased expression of B2M mRNA

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

BCL2 associated X, apoptosis regulator

increases expression

gallium nitrate results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

calreticulin

decreases expression

gallium nitrate results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

caspase 3

increases activity
multiple interactions

gallium nitrate results in increased activity of CASP3 protein
Bortezomib promotes the reaction [gallium nitrate results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases expression

gallium nitrate results in decreased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

DnaJ heat shock protein family (Hsp40) member A1

increases expression

gallium nitrate results in increased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

early growth response 1

increases expression

gallium nitrate results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

ferritin light chain 1

increases expression

gallium nitrate results in increased expression of FTL mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

glutathione peroxidase 4

decreases expression

gallium nitrate results in decreased expression of GPX4 mRNA

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

hypoxia inducible factor 1 subunit alpha

decreases expression

gallium nitrate results in decreased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

increases expression
multiple interactions

gallium nitrate results in increased expression of HMOX1 mRNA; gallium nitrate results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [gallium nitrate results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [gallium nitrate results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

decreases expression

gallium nitrate results in decreased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 9

decreases expression

gallium nitrate results in decreased expression of HSPA9 mRNA

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family B (small) member 1

decreases expression

gallium nitrate results in decreased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

decreases expression

gallium nitrate results in decreased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

metallothionein 2A

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [gallium nitrate results in increased expression of MT2A mRNA]
gallium nitrate results in increased expression of MT2A mRNA; gallium nitrate results in increased expression of MT2A protein

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

metallothionein 3

increases expression

gallium nitrate results in increased expression of MT3 mRNA

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

metal-regulatory transcription factor 1

increases expression

gallium nitrate results in increased expression of MTF1 mRNA

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

gallium nitrate results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases activity

SB 203580 inhibits the reaction [gallium nitrate results in increased activity of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

popeye domain cAMP effector 2

decreases expression

gallium nitrate results in decreased expression of POPDC2 mRNA

NCBI chr11:62,351,843...62,398,688
Ensembl chr11:62,374,759...62,390,756

G

peroxiredoxin 4

decreases expression

gallium nitrate results in decreased expression of PRDX4 mRNA

NCBI chr X:40,026,762...40,044,066
Ensembl chr X:40,026,651...40,044,066

G

parathyroid hormone

multiple interactions

gallium nitrate inhibits the reaction [Tamoxifen results in decreased expression of PTH protein]

NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530

G

solute carrier family 39 member 6

decreases expression

gallium nitrate results in decreased expression of SLC39A6 mRNA

NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417

G

solute carrier family 40 member 1

decreases expression

gallium nitrate results in decreased expression of SLC40A1 mRNA

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

superoxide dismutase 1

decreases expression

gallium nitrate results in decreased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression

gallium nitrate results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

transferrin

multiple interactions

gallium nitrate promotes the reaction [TF protein results in increased uptake of Iron]

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transferrin receptor

decreases expression

gallium nitrate results in decreased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

lead nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aconitase 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of ACO1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in decreased expression of ACO1 protein]

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

actin, alpha 1, skeletal muscle

increases expression

lead nitrate results in increased expression of ACTA1 protein

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

aryl hydrocarbon receptor

multiple interactions
increases expression

AHR promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; AHR promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]
lead nitrate results in increased expression of AHR mRNA; lead nitrate results in increased expression of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

A-kinase anchoring protein 3

decreases expression

lead nitrate results in decreased expression of AKAP3 mRNA

NCBI chr 4:159,688,049...159,714,067
Ensembl chr 4:159,699,289...159,713,903

G

aminolevulinate dehydratase

multiple interactions
decreases activity

lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]
lead nitrate results in decreased activity of ALAD protein

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

apoptotic peptidase activating factor 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of APAF1 protein
mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein]

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

Rho GDP dissociation inhibitor beta

increases expression

lead nitrate results in increased expression of ARHGDIB protein

NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658

G

arrestin domain containing 5

decreases expression

lead nitrate results in decreased expression of ARRDC5 mRNA

NCBI chr 9:1,126,644...1,132,736
Ensembl chr 9:1,126,644...1,132,816

G

antizyme inhibitor 2

decreases expression

lead nitrate results in decreased expression of AZIN2 mRNA

NCBI chr 5:141,281,310...141,310,415
Ensembl chr 5:141,281,249...141,310,397

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

mangiferin inhibits the reaction [lead nitrate results in increased expression of BAX protein]
[lead nitrate results in increased abundance of Lead] which results in increased expression of BAX mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of BAX mRNA]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of BAX mRNA]

PMID:23451106 PMID:30738203

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

lead nitrate results in decreased expression of BCL2 protein
[lead nitrate results in increased abundance of Lead] which results in decreased expression of BCL2 mRNA
mangiferin inhibits the reaction [lead nitrate results in decreased expression of BCL2 protein]

PMID:23451106 PMID:30738203

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

similar to human chromosome 1 open reading frame 56

decreases expression

lead nitrate results in decreased expression of C2H1ORF56 mRNA

NCBI chr 2:182,814,794...182,818,387
Ensembl chr 2:182,814,793...182,818,512

G

caspase 3

increases expression
multiple interactions
increases activity

lead nitrate results in increased expression of CASP3 protein
[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP3 protein; [lead nitrate results in increased abundance of Lead] which results in increased expression of CASP3 mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP3 protein]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of CASP3 mRNA]
puerarin inhibits the reaction [lead nitrate results in increased activity of CASP3 protein]
mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP3 protein]

PMID:23451106 PMID:24505050 PMID:30738203

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions
decreases expression

lead nitrate affects the reaction [CASP7 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CASP7 affects the expression of MT2 mRNA]
lead nitrate results in decreased expression of CASP7 mRNA

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

multiple interactions
increases expression

mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP9 protein]
[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP9 protein; [lead nitrate results in increased abundance of Lead] which results in increased expression of CASP9 mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP9 protein]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of CASP9 mRNA]

PMID:23451106 PMID:30738203

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases activity
multiple interactions

lead nitrate results in decreased activity of CAT protein
[lead nitrate results in increased abundance of Lead] which results in decreased activity of CAT protein; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased activity of CAT protein]
Ashwagandha inhibits the reaction [lead nitrate results in decreased activity of CAT protein]; puerarin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]
mangiferin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]

PMID:23315276 PMID:23451106 PMID:24987671 PMID:30738203

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin G1

multiple interactions

lead nitrate affects the reaction [CCNG1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT2 mRNA]

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

CD86 molecule

increases expression

lead nitrate results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

chromodomain Y-like

decreases expression

lead nitrate results in decreased expression of CDYL mRNA

NCBI chr17:28,982,009...29,204,345
Ensembl chr17:28,982,037...29,204,313

G

component of inhibitor of nuclear factor kappa B kinase complex

increases phosphorylation
multiple interactions

lead nitrate results in increased phosphorylation of CHUK protein
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of CHUK protein]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cytochrome c oxidase subunit 8C

decreases expression

lead nitrate results in decreased expression of COX8C mRNA

NCBI chr 6:122,028,566...122,029,889
Ensembl chr 6:122,028,566...122,029,889

G

cysteine-rich secretory protein 2

decreases expression

lead nitrate results in decreased expression of CRISP2 mRNA

NCBI chr 9:20,107,649...20,131,967
Ensembl chr 9:20,107,701...20,131,959

G

crystallin, alpha A

affects metabolic processing

lead nitrate affects the metabolism of CRYAA protein

NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349

G

crystallin, alpha B

affects metabolic processing

lead nitrate affects the metabolism of CRYAB protein

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

cystatin 8

decreases expression

lead nitrate results in decreased expression of CST8 mRNA

NCBI chr 3:136,244,586...136,255,412
Ensembl chr 3:136,244,636...136,251,273

G

catenin alpha 1

multiple interactions

lead nitrate affects the reaction [CTNNA1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT2 mRNA]

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

G

catenin beta 1

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased expression of and affects the localization of CTNNB1 protein; [lead nitrate results in increased abundance of Lead] which results in decreased expression of CTNNB1 mRNA; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of and affects the localization of CTNNB1 protein]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of CTNNB1 mRNA]
lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of CTNNB1 mRNA]

PMID:30731080 PMID:35738543

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cut-like homeobox 2

multiple interactions

lead nitrate affects the reaction [CUX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT2 mRNA]

NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

lead nitrate inhibits the reaction [1,2,5,6-dibenzanthracene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benz(a)anthracene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(b)fluoranthene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(k)fluoranthene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(k)fluoranthene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; lead nitrate promotes the reaction [benzo(k)fluoranthene results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [lead nitrate results in increased expression of CYP1A1 mRNA]
lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [lead nitrate results in increased expression of CYP1A1 mRNA]
lead nitrate results in increased expression of CYP1A1 mRNA; lead nitrate results in increased expression of CYP1A1 protein

PMID:8902619 PMID:11162773 PMID:11408366 PMID:17889500 PMID:23391631 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
multiple interactions

lead nitrate results in decreased activity of CYP1A2 protein
lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; lead nitrate results in decreased expression of and results in decreased activity of CYP1A2 protein

PMID:8902619 PMID:11162773

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, subfamily 2, polypeptide 11

increases expression

lead nitrate results in increased expression of CYP2C11 mRNA

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily j, polypeptide 3

increases expression

lead nitrate results in increased expression of CYP2J3 mRNA

NCBI chr 5:111,219,921...111,244,987
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 4, subfamily a, polypeptide 1

increases expression

lead nitrate results in increased expression of CYP4A1 mRNA

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily f, polypeptide 4

increases expression

lead nitrate results in increased expression of CYP4F4 mRNA

NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506

G

cytochrome P450, family 51

increases expression
multiple interactions

lead nitrate results in increased expression of CYP51 mRNA
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]

PMID:15475176 PMID:22293356

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of CYP7A1 mRNA
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]

PMID:15475176 PMID:16049268 PMID:22293356

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DNA-damage inducible transcript 3

increases expression

lead nitrate results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dickkopf WNT signaling pathway inhibitor 1

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 mRNA; [lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 protein]

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

dentin matrix acidic phosphoprotein 1

multiple interactions

lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of DMP1 mRNA]

NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323

G

deoxyribonuclease 1

multiple interactions

lead nitrate affects the reaction [DNASE1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT2 mRNA]

NCBI chr10:11,498,930...11,505,151
Ensembl chr10:11,498,931...11,501,869

G

DNA methyltransferase 3 alpha

multiple interactions
decreases expression

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]
lead nitrate results in decreased expression of DNMT3A mRNA; lead nitrate results in decreased expression of DNMT3A protein

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

dentin sialophosphoprotein

multiple interactions

lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of DSPP mRNA]

NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672

G

E2F transcription factor 1

multiple interactions

E2F1 protein inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; lead nitrate inhibits the reaction [E2F1 protein results in decreased expression of PTGS2 mRNA]

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

EGF-like-domain, multiple 8

increases expression

lead nitrate results in increased expression of EGFL8 protein

NCBI chr20:4,132,930...4,136,024
Ensembl chr20:4,133,629...4,136,018

G

epidermal growth factor receptor

multiple interactions
increases phosphorylation

EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; EGFR mutant form affects the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; EGFR mutant form affects the reaction [lead nitrate results in increased secretion of Dinoprostone]; EGFR promotes the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 2 alpha kinase 1

increases response to substance
multiple interactions

EIF2AK1 gene mutant form results in increased susceptibility to lead nitrate
[lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Bilirubin; [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Malondialdehyde; [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased expression of HAMP mRNA

NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
increases phosphorylation

puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of EIF4EBP1 protein]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

ERCC excision repair 1, endonuclease non-catalytic subunit

multiple interactions

lead nitrate affects the reaction [ERCC1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT2 mRNA]

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 3, TFIIH core complex helicase subunit

multiple interactions

lead nitrate affects the reaction [ERCC3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT2 mRNA]

NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329

G

ezrin

multiple interactions

lead nitrate affects the reaction [EZR affects the expression of MT1 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT2 mRNA]

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

fatty acid binding protein 9

decreases expression

lead nitrate results in decreased expression of FABP9 mRNA

NCBI chr 2:91,591,842...91,595,873
Ensembl chr 2:91,592,298...91,595,873

G

farnesyl diphosphate farnesyl transferase 1

increases expression

lead nitrate results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

increases expression

lead nitrate results in increased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

four and a half LIM domains 1

decreases expression

lead nitrate results in decreased expression of FHL1 mRNA

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

lead nitrate results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box A2

multiple interactions

lead nitrate affects the reaction [FOXA2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT2 mRNA]

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

ferritin light chain 1

increases expression

lead nitrate results in increased expression of FTL protein

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

glucose-6-phosphate dehydrogenase

decreases activity

lead nitrate results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, alpha

increases expression

lead nitrate results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

golgi associated RAB2 interactor 1B

decreases expression

lead nitrate results in decreased expression of GARIN1B mRNA

NCBI chr 4:57,915,184...57,938,593
Ensembl chr 4:57,920,790...57,938,591

G

glial fibrillary acidic protein

multiple interactions
increases expression

Ashwagandha inhibits the reaction [lead nitrate results in increased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in increased expression of GFAP protein]
lead nitrate results in increased expression of GFAP mRNA; lead nitrate results in increased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

gametogenetin binding protein 1

decreases expression

lead nitrate results in decreased expression of GGNBP1 mRNA

NCBI chr20:5,109,849...5,116,185
Ensembl chr20:5,099,311...5,116,183

G

growth hormone 1

multiple interactions
decreases secretion

lead nitrate inhibits the reaction [GHRH protein results in increased expression of GH1 protein]
lead nitrate results in decreased secretion of GH1 protein

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

growth hormone releasing hormone

multiple interactions

lead nitrate inhibits the reaction [GHRH protein results in increased expression of GH1 protein]

NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889

G

gap junction protein, alpha 5

multiple interactions
increases expression

lead nitrate affects the reaction [GJA5 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT2 mRNA]
lead nitrate results in increased expression of GJA5 mRNA

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

G

gap junction protein, beta 2

multiple interactions

lead nitrate affects the reaction [GJB2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT2 mRNA]

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions

lead nitrate affects the reaction [GRIN2A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT2 mRNA]

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2C

increases expression

lead nitrate results in increased expression of GRIN2C mRNA

NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427

G

germ cell associated 1

decreases expression

lead nitrate results in decreased expression of GSG1 mRNA

NCBI chr 4:168,090,773...168,107,039
Ensembl chr 4:168,090,776...168,107,039

G

glycogen synthase kinase 3 beta

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions
decreases activity

mangiferin inhibits the reaction [lead nitrate results in decreased activity of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of GSTA1 mRNA
AHR promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; RELA promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; Resveratrol inhibits the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase theta 1

multiple interactions

lead nitrate affects the reaction [GSTT1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT2 mRNA]

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

hepcidin antimicrobial peptide

multiple interactions

[lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased expression of HAMP mRNA

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

high-mobility group box 4

decreases expression

lead nitrate results in decreased expression of HMGB4 mRNA

NCBI chr 5:140,616,040...140,616,722
Ensembl chr 5:140,615,197...140,616,770

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression
multiple interactions

lead nitrate results in increased expression of HMGCR mRNA
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]

PMID:15475176 PMID:16705668 PMID:22293356

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

increases expression

lead nitrate results in increased expression of HMOX1 mRNA

PMID:23391631 PMID:34189835

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hepatocyte nuclear factor 4, alpha

decreases expression

lead nitrate results in decreased expression of HNF4A mRNA

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

heat shock protein 90 alpha family class B member 1

multiple interactions

lead nitrate affects the reaction [HSP90AB1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT2 mRNA]

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 2

multiple interactions
decreases expression
increases expression

Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA2 mRNA]
lead nitrate results in decreased expression of HSPA2 mRNA

PMID:21628963 PMID:24987671

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 5

increases expression

lead nitrate results in increased expression of HSPA5 protein
lead nitrate results in increased expression of HSPA5 mRNA

PMID:14971657 PMID:20435106

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 9

multiple interactions
increases expression

Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA9 mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA9 protein]
lead nitrate results in increased expression of HSPA9 mRNA; lead nitrate results in increased expression of HSPA9 protein

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

insulin-like growth factor 2

multiple interactions

lead nitrate affects the reaction [IGF2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT2 mRNA]

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor binding protein 6

multiple interactions

lead nitrate affects the reaction [IGFBP6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT2 mRNA]

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

G

interleukin 1 alpha

multiple interactions
increases expression

[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] results in decreased susceptibility to lead nitrate
lead nitrate results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression

[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] results in decreased susceptibility to lead nitrate
lead nitrate results in increased expression of IL1B mRNA
lead nitrate results in increased expression of IL1B mRNA; lead nitrate results in increased expression of IL1B protein

PMID:15475176 PMID:16049268 PMID:22293356

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

decreases secretion

lead nitrate results in decreased secretion of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6 receptor

multiple interactions

lead nitrate affects the reaction [IL6RA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT2 mRNA]

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

insulin 1

multiple interactions

[lead nitrate results in increased abundance of Lead] inhibits the reaction [Glucose results in increased secretion of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

IQ motif containing F1

decreases expression

lead nitrate results in decreased expression of IQCF1 mRNA

NCBI chr 8:107,129,462...107,133,242
Ensembl chr 8:107,130,704...107,133,249

G

IQ motif containing F5

decreases expression

lead nitrate results in decreased expression of IQCF5 mRNA

NCBI chr 8:107,151,477...107,152,862
Ensembl chr 8:107,151,462...107,152,869

G

integrin subunit alpha 6

multiple interactions

lead nitrate affects the reaction [ITGA6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT2 mRNA]

NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428

G

integrin subunit alpha M

multiple interactions

lead nitrate affects the reaction [ITGAM affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT2 mRNA]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

keratin 14

increases expression

lead nitrate results in increased expression of KRT14 protein

NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799

G

lysosomal-associated membrane protein 1

increases expression

lead nitrate results in increased expression of LAMP1 protein

NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883

G

lysosomal-associated membrane protein 2

increases expression

lead nitrate results in increased expression of LAMP2 protein

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

lactate dehydrogenase C

decreases expression

lead nitrate results in decreased expression of LDHC mRNA

NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378

G

leucine rich repeat containing 46

decreases expression

lead nitrate results in decreased expression of LRRC46 mRNA

NCBI chr10:82,021,314...82,033,575
Ensembl chr10:82,021,330...82,033,724

G

lymphotoxin alpha

multiple interactions

lead nitrate affects the reaction [LTA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT2 mRNA]

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

Ly6/Plaur domain containing 4

decreases expression

lead nitrate results in decreased expression of LYPD4 mRNA

NCBI chr 1:80,460,487...80,466,105
Ensembl chr 1:80,460,487...80,466,011

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]

PMID:20850495 PMID:22502979 PMID:23451106

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]

PMID:20850495 PMID:22502979 PMID:23451106

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

membrane associated ring-CH-type finger 11

decreases expression

lead nitrate results in decreased expression of MARCHF11 mRNA

NCBI chr 2:76,898,330...76,999,690
Ensembl chr 2:76,898,386...76,999,691

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

lead nitrate affects the reaction [MCL1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT2 mRNA]

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

MET proto-oncogene, receptor tyrosine kinase

multiple interactions

lead nitrate affects the reaction [MET affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT2 mRNA]

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

microsomal glutathione S-transferase 1

multiple interactions

lead nitrate affects the reaction [MGST1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT2 mRNA]

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

microRNA 139

increases expression

lead nitrate results in increased expression of MIR139 mRNA

NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902

G

microRNA 142

increases expression

lead nitrate results in increased expression of MIR142 mRNA

NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967

G

maestro heat-like repeat family member 2B

decreases expression

lead nitrate results in decreased expression of MROH2B mRNA

NCBI chr 2:54,003,870...54,063,992
Ensembl chr 2:54,003,862...54,063,984

G

mitochondrially encoded cytochrome c oxidase I

multiple interactions
decreases expression

puerarin inhibits the reaction [lead nitrate results in decreased expression of COX1 mRNA]

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions
decreases expression

puerarin inhibits the reaction [lead nitrate results in decreased expression of COX2 mRNA]

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

G

mitochondrially encoded cytochrome c oxidase III

multiple interactions
decreases expression

puerarin inhibits the reaction [lead nitrate results in decreased expression of COX3 mRNA]

NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382

G

metallothionein 1

increases expression
affects localization
decreases response to substance
multiple interactions

lead nitrate results in increased expression of MT1 mRNA
lead nitrate affects the localization of MT1 protein
MT1 results in decreased susceptibility to lead nitrate
lead nitrate affects the reaction [CASP7 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT1 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT1 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RAD23 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SERPINA1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT1 mRNA]; MT1 protein promotes the reaction [lead nitrate results in increased expression of SNCA mRNA]

PMID:11891201 PMID:19542206

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 2A

multiple interactions
decreases response to substance

lead nitrate affects the reaction [CASP7 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT2 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT2 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT2 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT2 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT2 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RAD23 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SERPINA1B affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT2 mRNA]
MT2 results in decreased susceptibility to lead nitrate

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

mechanistic target of rapamycin kinase

increases phosphorylation
multiple interactions

lead nitrate results in increased phosphorylation of MTOR protein
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

lead nitrate affects the reaction [MYC affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT2 mRNA]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin heavy chain 6

decreases expression

lead nitrate results in decreased expression of MYH6 protein

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin heavy chain 7

increases expression
multiple interactions

lead nitrate results in increased expression of MYH7 mRNA; lead nitrate results in increased expression of MYH7 protein
resveratrol inhibits the reaction [lead nitrate results in increased expression of MYH7 mRNA]

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

neural cell adhesion molecule 1

multiple interactions
decreases expression

Ashwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 protein]
lead nitrate results in decreased expression of NCAM1 mRNA; lead nitrate results in decreased expression of NCAM1 protein

NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014

G

NFKB inhibitor alpha

decreases expression
multiple interactions

lead nitrate results in decreased expression of NFKBIA protein
mangiferin inhibits the reaction [lead nitrate results in decreased expression of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor beta

multiple interactions

lead nitrate affects the reaction [NFKBIB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT2 mRNA]

NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862

G

natriuretic peptide B

increases expression

lead nitrate results in increased expression of NPPB mRNA

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

NAD(P)H quinone dehydrogenase 1

increases expression

lead nitrate results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

lead nitrate results in decreased expression of NR0B2 mRNA

PMID:15475176 PMID:16049268

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group H, member 3

decreases expression

lead nitrate results in decreased expression of NR1H3 mRNA

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

nuclear receptor subfamily 5, group A, member 2

increases expression

lead nitrate results in increased expression of NR5A2 mRNA

NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326

G

NUMB, endocytic adaptor protein

multiple interactions

lead nitrate affects the reaction [NUMB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT2 mRNA]

NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354

G

outer dense fiber of sperm tails 1

decreases expression

lead nitrate results in decreased expression of ODF1 mRNA

NCBI chr 7:69,377,427...69,389,662
Ensembl chr 7:69,380,116...69,389,664

G

3-oxoacid CoA transferase 2A

decreases expression

lead nitrate results in decreased expression of OXCT2A mRNA

NCBI chr 5:135,600,812...135,602,570
Ensembl chr 5:135,591,507...135,602,569

G

progestin and adipoQ receptor family member 5

decreases expression

lead nitrate results in decreased expression of PAQR5 mRNA

NCBI chr 8:62,431,867...62,513,688
Ensembl chr 8:62,431,867...62,513,688

G

protein inhibitor of activated STAT, 2

multiple interactions

lead nitrate affects the reaction [PIAS2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT2 mRNA]

NCBI chr18:70,608,034...70,714,295
Ensembl chr18:70,607,665...70,710,033

G

phospholipase A2 group 4A

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; [lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone; EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; EGFR mutant form affects the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; EGFR promotes the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]

NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266

G

DNA polymerase delta 1, catalytic subunit

multiple interactions

lead nitrate affects the reaction [POLD1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT2 mRNA]

NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465

G

POU class 3 homeobox 3

multiple interactions

lead nitrate affects the reaction [POU3F3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT2 mRNA]

NCBI chr 9:44,945,872...44,948,998
Ensembl chr 9:44,945,872...44,948,992

G

protamine 1

decreases expression

lead nitrate results in decreased expression of PRM1 mRNA

NCBI chr10:4,871,817...4,872,312

G

protamine 3

decreases expression

lead nitrate results in decreased expression of PRM3 mRNA

NCBI chr10:4,877,471...4,877,985
Ensembl chr10:4,877,471...4,877,985

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PTGS2 protein]; [lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone; Decitabine promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; lead nitrate inhibits the reaction [E2F1 protein results in decreased expression of PTGS2 mRNA]; lead nitrate promotes the reaction [RB1 protein results in increased expression of PTGS2 mRNA]; RB1 protein promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 protein]
lead nitrate results in increased expression of PTGS2 mRNA; lead nitrate results in increased expression of PTGS2 protein

PMID:20850495 PMID:21435385 PMID:24639330

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RB transcriptional corepressor 1

multiple interactions
increases expression

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of RB1 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of RB1 protein]; lead nitrate promotes the reaction [RB1 protein results in increased expression of PTGS2 mRNA]; RB1 protein promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 protein]

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RB transcriptional corepressor like 2

multiple interactions

lead nitrate affects the reaction [RBL2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT2 mRNA]

NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases expression

mangiferin inhibits the reaction [lead nitrate results in increased expression of RELA protein]
RELA promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; RELA promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]
lead nitrate results in increased expression of RELA mRNA; lead nitrate results in increased expression of RELA protein

PMID:23451106 PMID:31682781

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RIB43A domain with coiled-coils 2

decreases expression

lead nitrate results in decreased expression of RIBC2 mRNA

NCBI chr 7:116,242,863...116,257,868
Ensembl chr 7:116,242,863...116,257,863

G

ribosomal protein S6 kinase B1

multiple interactions
increases phosphorylation

puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of RPS6KB1 protein]

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

RUNX family transcription factor 1

multiple interactions

lead nitrate affects the reaction [RUNX1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT2 mRNA]

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

RUNX family transcription factor 2

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 mRNA; [lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 protein]
lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of RUNX2 mRNA]

PMID:30731080 PMID:35738543

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

sperm mitochondria-associated cysteine-rich protein

decreases expression

lead nitrate results in decreased expression of SMCP mRNA

NCBI chr 2:178,160,948...178,165,951
Ensembl chr 2:178,160,127...178,166,001

G

synuclein alpha

affects localization
multiple interactions
increases expression

lead nitrate affects the localization of SNCA protein
MT1 protein promotes the reaction [lead nitrate results in increased expression of SNCA mRNA]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

suppressor of cytokine signaling 1

multiple interactions

lead nitrate affects the reaction [SOCS1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT2 mRNA]

NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383

G

superoxide dismutase 1

multiple interactions
decreases activity

Ashwagandha inhibits the reaction [lead nitrate results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

Sp3 transcription factor

multiple interactions
decreases expression

lead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT2 mRNA]
lead nitrate results in decreased expression of SP3 mRNA

NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342

G

spermatogenesis associated 18

decreases expression

lead nitrate results in decreased expression of SPATA18 mRNA

NCBI chr14:34,531,931...34,558,671
Ensembl chr14:34,531,061...34,558,687

G

spermatogenesis associated 20

decreases expression

lead nitrate results in decreased expression of SPATA20 mRNA

NCBI chr10:79,427,525...79,435,472
Ensembl chr10:79,427,528...79,434,368

G

spermatogenesis associated 21

decreases expression

lead nitrate results in decreased expression of SPATA21 mRNA

NCBI chr 5:153,393,309...153,419,430
Ensembl chr 5:153,393,365...153,418,561

G

spermatogenesis associated 6

decreases expression

lead nitrate results in decreased expression of SPATA6 mRNA

NCBI chr 5:126,593,122...126,676,557
Ensembl chr 5:126,593,122...126,676,557

G

Spetex-2B protein

decreases expression

lead nitrate results in decreased expression of SPETEX2B mRNA

G

Spetex-2D protein

decreases expression

lead nitrate results in decreased expression of SPETEX2D mRNA

G

Spetex-2F protein

decreases expression

lead nitrate results in decreased expression of SPETEX2F mRNA

NCBI chr15:17,716,315...17,720,203
Ensembl chr15:17,716,358...17,733,744

G

sequestosome 1

multiple interactions
increases expression

lead nitrate affects the reaction [SQSTM1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT2 mRNA]
puerarin inhibits the reaction [lead nitrate results in increased expression of SQSTM1 protein]

PMID:11891201 PMID:27762461

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 2

increases expression

lead nitrate results in increased expression of SREBF2 mRNA

PMID:15475176 PMID:16705668

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

small ubiquitin-like modifier 1

multiple interactions

lead nitrate affects the reaction [SUMO1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT2 mRNA]

NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761

G

T-box transcription factor 2

multiple interactions

lead nitrate affects the reaction [TBX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT2 mRNA]

NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529

G

tektin 2

decreases expression

lead nitrate results in decreased expression of TEKT2 mRNA

NCBI chr 5:138,619,665...138,623,301
Ensembl chr 5:138,619,667...138,623,204

G

tektin 4

decreases expression

lead nitrate results in decreased expression of TEKT4 mRNA

NCBI chr10:14,487,760...14,492,936
Ensembl chr10:14,487,760...14,492,936

G

tropomodulin 1

decreases expression

lead nitrate results in decreased expression of TMOD1 mRNA

NCBI chr 5:60,316,445...60,393,957
Ensembl chr 5:60,338,512...60,393,956

G

tumor necrosis factor

multiple interactions
increases expression

[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]
Lead nitrate increases expression of Tnf mRNA in liver

CTD
RGD

PMID:15475176 PMID:16049268 PMID:22293356 PMID:9049203 PMID:7943184

RGD:14995487, RGD:14995476

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

multiple interactions

lead nitrate affects the reaction [TNFRSF1A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT2 mRNA]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

multiple interactions

lead nitrate affects the reaction [TNFRSF1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT2 mRNA]

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

transition protein 1

decreases expression

lead nitrate results in decreased expression of TNP1 mRNA

NCBI chr 9:74,594,463...74,595,072
Ensembl chr 9:74,594,466...74,595,274

G

transition protein 2

decreases expression

lead nitrate results in decreased expression of TNP2 mRNA

NCBI chr10:4,879,812...4,880,540
Ensembl chr10:4,879,812...4,880,538

G

tumor protein p53

multiple interactions
increases expression

[lead nitrate results in increased abundance of Lead] which results in increased expression of TP53 mRNA; AHR promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]; RELA promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of TP53 mRNA]

PMID:30738203 PMID:31682781

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tubulin polymerization-promoting protein family member 2

decreases expression

lead nitrate results in decreased expression of TPPP2 mRNA

NCBI chr15:24,614,284...24,627,123
Ensembl chr15:24,614,006...24,618,967

G

tripartite motif-containing 27

multiple interactions

lead nitrate affects the reaction [TRIM27 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT2 mRNA]

NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643

G

transient receptor potential cation channel, subfamily M, member 2

multiple interactions

lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]

NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181

G

TSC22 domain family, member 3

multiple interactions

[lead nitrate results in increased abundance of Lead] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]

NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861

G

tumor susceptibility 101

multiple interactions

lead nitrate affects the reaction [TSG101 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT2 mRNA]

NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554

G

testis-specific serine kinase 2

decreases expression

lead nitrate results in decreased expression of TSSK2 mRNA

NCBI chr11:83,086,578...83,087,933

G

testis-specific serine kinase 3

decreases expression

lead nitrate results in decreased expression of TSSK3 mRNA

NCBI chr 5:141,827,606...141,829,255
Ensembl chr 5:141,827,606...141,829,255

G

transcription termination factor 1

multiple interactions

lead nitrate affects the reaction [TTF1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT2 mRNA]

NCBI chr 3:12,384,626...12,409,257
Ensembl chr 3:12,384,655...12,409,257

G

tubulin, alpha 8

decreases expression

lead nitrate results in decreased expression of TUBA8 mRNA

NCBI chr 4:154,440,045...154,456,918
Ensembl chr 4:154,440,074...154,456,917

G

TUB like protein 2

decreases expression

lead nitrate results in decreased expression of TULP2 mRNA

NCBI chr 1:95,962,496...95,999,775
Ensembl chr 1:95,962,496...96,000,628

G

Wnt family member 1

multiple interactions

lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of WNT1 mRNA]

NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651

G

Wnt family member 3A

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA; [lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein]

NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324

G

Wnt family member 4

multiple interactions

lead nitrate affects the reaction [WNT4 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT2 mRNA]

NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859

G

zinc finger homeobox 3

multiple interactions

lead nitrate affects the reaction [ZFHX3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT2 mRNA]

NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771

G

zinc and ring finger 4

decreases expression

lead nitrate results in decreased expression of ZNRF4 mRNA

NCBI chr 9:1,353,308...1,354,496
Ensembl chr 9:1,353,306...1,354,584

potassium nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

coiled-coil domain containing 120

decreases expression

potassium nitrate results in decreased expression of CCDC120 mRNA

NCBI chr X:14,753,594...14,772,745
Ensembl chr X:14,753,696...14,772,743

G

CDC-like kinase 1

decreases expression

potassium nitrate results in decreased expression of CLK1 mRNA

NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000

G

DNA cross-link repair 1C

increases expression

potassium nitrate results in increased expression of DCLRE1C mRNA

NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186

G

ferritin heavy chain 1

increases expression

potassium nitrate results in increased expression of FTH1 mRNA

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

ferritin light chain 1

increases expression

potassium nitrate results in increased expression of FTL mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

high mobility group box 1

increases expression

potassium nitrate results in increased expression of HMGB1 mRNA

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

high mobility group box 2

increases expression

potassium nitrate results in increased expression of HMGB2 mRNA

NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140

G

proliferating cell nuclear antigen

increases expression

potassium nitrate results in increased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

septin 7

decreases expression

potassium nitrate results in decreased expression of SEPTIN7 mRNA

NCBI chr 8:23,719,448...23,783,247
Ensembl chr 8:23,716,030...23,783,243

G

stathmin 1

increases expression

potassium nitrate results in increased expression of STMN1 mRNA

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

vascular endothelial growth factor A

decreases expression

potassium nitrate results in decreased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

silver(1+) nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

multiple interactions
increases response to substance

[ABCC1 protein results in increased susceptibility to Silver Nitrate] which results in decreased export of calcein AM

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATM serine/threonine kinase

increases expression

Silver Nitrate analog results in increased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATR serine/threonine kinase

increases expression

Silver Nitrate analog results in increased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

aurora kinase A

increases expression
multiple interactions

Silver Nitrate results in increased expression of AURKA protein modified form
CFL1 mRNA promotes the reaction [Silver Nitrate results in increased expression of AURKA protein modified form]

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

aurora kinase B

increases phosphorylation
multiple interactions

Silver Nitrate results in increased phosphorylation of AURKB protein
CFL1 mRNA promotes the reaction [Silver Nitrate results in increased phosphorylation of AURKB protein]

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

aurora kinase C

increases expression
multiple interactions

Silver Nitrate results in increased expression of AURKC protein modified form
CFL1 mRNA promotes the reaction [Silver Nitrate results in increased expression of AURKC protein modified form]

NCBI chr 1:66,843,653...66,849,775
Ensembl chr 1:66,843,653...66,864,386

G

BUB1 mitotic checkpoint serine/threonine kinase

increases expression

Silver Nitrate analog results in increased expression of BUB1 mRNA; Silver Nitrate results in increased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

BUB1 mitotic checkpoint serine/threonine kinase B

increases expression

Silver Nitrate analog results in increased expression of BUB1B mRNA; Silver Nitrate results in increased expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

catalase

increases expression

Silver Nitrate results in increased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin A2

decreases expression

Silver Nitrate analog results in decreased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

Silver Nitrate analog results in decreased expression of CCNB1 mRNA; Silver Nitrate results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin E1

increases expression

Silver Nitrate analog results in increased expression of CCNE1 mRNA; Silver Nitrate results in increased expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

Cd28 molecule

multiple interactions
affects response to substance

CD28 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]
CD28 protein affects the susceptibility to Silver Nitrate

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

cell division cycle 14A

increases expression

Silver Nitrate analog results in increased expression of CDC14A mRNA

NCBI chr 2:204,225,540...204,380,927
Ensembl chr 2:204,225,540...204,380,927

G

cell division cycle 25B

affects expression

Silver Nitrate analog affects the expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cell division cycle 25C

affects expression

Silver Nitrate analog affects the expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 45

increases expression

Silver Nitrate analog results in increased expression of CDC45 mRNA; Silver Nitrate results in increased expression of CDC45 mRNA

NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619

G

cell division cycle 6

increases expression

Silver Nitrate analog results in increased expression of CDC6 mRNA; Silver Nitrate results in increased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cell division cycle 7

affects expression
increases expression

Silver Nitrate analog affects the expression of CDC7 mRNA
Silver Nitrate results in increased expression of CDC7 mRNA

NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778

G

cyclin-dependent kinase 1

affects expression

Silver Nitrate analog affects the expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase inhibitor 2A

increases expression

Silver Nitrate results in increased expression of CDKN2A mRNA

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2C

affects expression

Silver Nitrate analog affects the expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

cofilin 1

multiple interactions

CFL1 mRNA promotes the reaction [Silver Nitrate results in increased expression of AURKA protein modified form]; CFL1 mRNA promotes the reaction [Silver Nitrate results in increased expression of AURKC protein modified form]; CFL1 mRNA promotes the reaction [Silver Nitrate results in increased phosphorylation of AURKB protein]

NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587

G

checkpoint kinase 1

increases expression

Silver Nitrate analog results in increased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

increases expression

Silver Nitrate analog results in increased expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

DBF4-CDC7 kinase regulatory subunit

increases expression

Silver Nitrate analog results in increased expression of DBF4 mRNA; Silver Nitrate results in increased expression of DBF4 mRNA

NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066

G

discs large MAGUK scaffold protein 4

decreases expression

Silver Nitrate results in decreased expression of DLG4 protein

NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153

G

DnaJ heat shock protein family (Hsp40) member A1

increases expression

Silver Nitrate analog results in increased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

Silver Nitrate analog results in increased expression of DNAJB1 mRNA

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member C19

decreases expression

Silver Nitrate analog results in decreased expression of DNAJC19 mRNA

NCBI chr 2:116,923,272...116,945,312
Ensembl chr 2:116,923,272...116,945,264

G

E2F transcription factor 1

increases expression

Silver Nitrate analog results in increased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 2

increases expression

Silver Nitrate analog results in increased expression of E2F2 mRNA

NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217

G

E2F transcription factor 3

increases expression

Silver Nitrate analog results in increased expression of E2F3 mRNA

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

E2F transcription factor 4

increases expression

Silver Nitrate results in increased expression of E2F4 mRNA

NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806

G

E2F transcription factor 5

increases expression

Silver Nitrate results in increased expression of E2F5 mRNA

NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990

G

fibrillarin

multiple interactions
decreases activity

CD28 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]; IFNG protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]; IL4 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]; IL6 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]

NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Silver Nitrate results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

decreases expression

Silver Nitrate results in decreased expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

glucose-6-phosphate dehydrogenase

decreases activity

Silver Nitrate results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glutamate-cysteine ligase, catalytic subunit

decreases expression

Silver Nitrate results in decreased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutathione peroxidase 1

increases expression

Silver Nitrate results in increased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 7

increases expression

Silver Nitrate results in increased expression of GPX7 mRNA

NCBI chr 5:123,145,151...123,153,141
Ensembl chr 5:123,144,331...123,153,004

G

H1.5 linker histone, cluster member

decreases expression

Silver Nitrate analog results in decreased expression of H1-5 mRNA; Silver Nitrate results in decreased expression of H1-5 mRNA

NCBI chr17:42,726,132...42,727,162
Ensembl chr17:42,726,127...42,769,160

G

H1.3 linker histone, cluster member

decreases expression

Silver Nitrate analog results in decreased expression of H1-3 mRNA

NCBI chr17:41,551,524...41,552,303
Ensembl chr17:41,529,667...41,552,334

G

heme oxygenase 1

multiple interactions
increases expression

Silver Nitrate promotes the reaction [HSF1 protein binds to HMOX1 promoter]
Silver Nitrate results in increased expression of HMOX1 mRNA

PMID:17244614 PMID:27180073

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock transcription factor 1

multiple interactions
increases activity

Silver Nitrate promotes the reaction [HSF1 protein binds to HMOX1 promoter]; Silver Nitrate promotes the reaction [HSF1 protein binds to HSPA1A enhancer]; Silver Nitrate promotes the reaction [HSF1 protein binds to HSPA1A promoter]
Silver Nitrate results in increased activity of HSF1 protein

PMID:16460681 PMID:17244614 PMID:34170685

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein 90 alpha family class A member 1

increases expression

Silver Nitrate analog results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family A (Hsp70) member 12A

decreases expression

Silver Nitrate analog results in decreased expression of HSPA12A mRNA

NCBI chr 1:257,935,642...258,096,602
Ensembl chr 1:257,935,644...258,096,846

G

heat shock protein family A (Hsp70) member 12B

increases expression

Silver Nitrate analog results in increased expression of HSPA12B mRNA

NCBI chr 3:118,346,372...118,364,374
Ensembl chr 3:118,346,354...118,364,737

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
increases expression

Silver Nitrate promotes the reaction [HSF1 protein binds to HSPA1A enhancer]; Silver Nitrate promotes the reaction [HSF1 protein binds to HSPA1A promoter]
Silver Nitrate results in increased expression of HSPA1A mRNA

PMID:16460681 PMID:17244614 PMID:27180073

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

Silver Nitrate analog results in increased expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

G

heat shock protein family B (small) member 9

increases expression

Silver Nitrate analog results in increased expression of HSPB9 mRNA

NCBI chr10:85,641,284...85,641,929
Ensembl chr10:85,641,284...85,641,929

G

heat shock protein family H (Hsp110) member 1

increases expression

Silver Nitrate analog results in increased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

interferon gamma

affects response to substance
multiple interactions

IFNG protein affects the susceptibility to Silver Nitrate
IFNG protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

intraflagellar transport 25

decreases expression

Silver Nitrate analog results in decreased expression of IFT25 mRNA

NCBI chr 5:122,035,588...122,062,421
Ensembl chr 5:122,035,581...122,062,421

G

interleukin 1 beta

increases expression

Silver Nitrate results in increased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

affects response to substance
multiple interactions

IL4 protein affects the susceptibility to Silver Nitrate
IL4 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

affects response to substance
multiple interactions

IL6 protein affects the susceptibility to Silver Nitrate
IL6 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

KIT ligand

increases expression

Silver Nitrate results in increased expression of KITLG mRNA

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

microtubule-associated protein 2

decreases expression

Silver Nitrate results in decreased expression of MAP2 protein

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase 1

increases phosphorylation

Silver Nitrate results in increased phosphorylation of MAPK1 protein

PMID:27624343 PMID:35963315

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

Silver Nitrate results in increased phosphorylation of MAPK3 protein

PMID:27624343 PMID:35963315

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

minichromosome maintenance complex component 3

decreases expression

Silver Nitrate analog results in decreased expression of MCM3 mRNA

NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314

G

minichromosome maintenance complex component 4

increases expression

Silver Nitrate results in increased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 6

increases expression

Silver Nitrate results in increased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

metallothionein 1

multiple interactions
increases expression

MTF1 mutant form inhibits the reaction [Silver Nitrate results in increased expression of MT1A mRNA]
Silver Nitrate results in increased expression of MT1 mRNA
Silver Nitrate analog results in increased expression of MT1A mRNA; Silver Nitrate results in increased expression of MT1A mRNA

PMID:19733233 PMID:22831968 PMID:23333424 PMID:27624343

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 1, pseudogene 3

increases expression

Silver Nitrate analog results in increased expression of MT1E mRNA; Silver Nitrate results in increased expression of MT1E mRNA

NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2A

increases expression

Silver Nitrate results in increased expression of MT2A mRNA
Silver Nitrate results in increased expression of MT2 mRNA

PMID:10362023 PMID:20491607 PMID:23333424 PMID:27180073 PMID:27624343

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

metallothionein 3

increases expression

Silver Nitrate analog results in increased expression of MT3 mRNA

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

metallothionein 4

increases expression

Silver Nitrate analog results in increased expression of MT4 mRNA; Silver Nitrate results in increased expression of MT4 mRNA

NCBI chr19:10,863,813...10,865,909
Ensembl chr19:10,863,813...10,865,909

G

metal-regulatory transcription factor 1

multiple interactions
increases activity

MTF1 mutant form inhibits the reaction [Silver Nitrate results in increased expression of MT1A mRNA]; MTF1 mutant form inhibits the reaction [Silver Nitrate results in increased expression of SLC30A1 mRNA]
Silver Nitrate results in increased activity of MTF1 protein

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

NFE2 like bZIP transcription factor 2

decreases expression
increases activity

Silver Nitrate results in decreased expression of NFE2L2 mRNA
Silver Nitrate results in increased activity of NFE2L2 protein

PMID:19733233 PMID:23872425

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

origin recognition complex, subunit 6

increases expression

Silver Nitrate results in increased expression of ORC6 mRNA

NCBI chr19:21,757,867...21,765,638
Ensembl chr19:21,757,866...21,765,662

G

proliferating cell nuclear antigen

increases expression

Silver Nitrate analog results in increased expression of PCNA mRNA; Silver Nitrate results in increased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

PTEN induced kinase 1

increases expression

Silver Nitrate results in increased expression of PINK1 protein

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

polo-like kinase 1

decreases expression

Silver Nitrate analog results in decreased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

PPARG coactivator 1 alpha

decreases expression

Silver Nitrate results in decreased expression of PPARGC1A protein

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

PTTG1 regulator of sister chromatid separation, securin

increases expression
affects expression

Silver Nitrate results in increased expression of PTTG1 mRNA
Silver Nitrate analog affects the expression of PTTG1 mRNA

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

RB transcriptional corepressor like 1

increases expression

Silver Nitrate analog results in increased expression of RBL1 mRNA; Silver Nitrate results in increased expression of RBL1 mRNA

NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330

G

RB transcriptional corepressor like 2

increases expression

Silver Nitrate analog results in increased expression of RBL2 mRNA; Silver Nitrate results in increased expression of RBL2 mRNA

NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572

G

S-phase kinase associated protein 2

increases expression

Silver Nitrate analog results in increased expression of SKP2 mRNA

NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338

G

solute carrier family 30 member 1

multiple interactions
increases expression

MTF1 mutant form inhibits the reaction [Silver Nitrate results in increased expression of SLC30A1 mRNA]

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

G

solute carrier family 31 member 1

increases expression

Silver Nitrate results in increased expression of SLC31A1 mRNA

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

SMAD family member 2

decreases expression
increases expression

Silver Nitrate analog results in decreased expression of SMAD2 mRNA
Silver Nitrate results in increased expression of SMAD2 mRNA

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 3

decreases expression
increases expression

Silver Nitrate analog results in decreased expression of SMAD3 mRNA
Silver Nitrate results in increased expression of SMAD3 mRNA

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

superoxide dismutase 1

increases expression

Silver Nitrate results in increased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

Sp1 transcription factor

increases expression

Silver Nitrate results in increased expression of SP1 mRNA

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

synaptophysin

increases expression

Silver Nitrate results in increased expression of SYP protein

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

transcription factor Dp-1

increases expression

Silver Nitrate analog results in increased expression of TFDP1 mRNA

NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817

G

transcription factor Dp-2

increases expression

Silver Nitrate analog results in increased expression of TFDP2 mRNA

NCBI chr 8:96,760,459...96,901,466
Ensembl chr 8:96,760,504...96,896,682

G

tumor protein p53

decreases expression

Silver Nitrate analog results in decreased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thyroid peroxidase

increases expression

Silver Nitrate results in increased expression of TPO mRNA

NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199

sodium nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA dehydrogenase, long chain

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of ACADL protein]

NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220

G

actin, alpha, cardiac muscle 1

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of ACTC1 protein]

NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523

G

alpha-fetoprotein

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of AFP protein]

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

ATP synthase F1 subunit beta

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of ATP5F1B protein]

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase peripheral stalk subunit d

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of ATP5PD protein]

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

calcium voltage-gated channel auxiliary subunit alpha2delta 1

increases expression

sodium nitrate results in increased expression of CACNA2D1 protein

NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969

G

calsequestrin 1

increases expression

sodium nitrate results in increased expression of CASQ1 protein

NCBI chr13:84,670,648...84,680,339
Ensembl chr13:84,670,649...84,680,339

G

catalase

decreases activity

sodium nitrate results in decreased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cytochrome c oxidase subunit 4i1

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of COX4I1 protein]

NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921

G

crystallin, alpha B

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of CRYAB protein]

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

dual oxidase 2

affects expression

sodium nitrate affects the expression of DUOX2 mRNA

NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902

G

fatty acid binding protein 3

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of FABP3 protein]

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

ferritin heavy chain 1

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of FTH1 protein]

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

glucose-6-phosphate dehydrogenase

decreases activity

sodium nitrate results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glutamic-oxaloacetic transaminase 1

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutathione-disulfide reductase

multiple interactions

[Quercetin co-treated with sodium nitrate] results in increased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of IDH3A protein]

NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084

G

lactate dehydrogenase C

decreases activity

sodium nitrate results in decreased activity of LDHC protein

NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378

G

myoglobin

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of MB protein]

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

myeloperoxidase

multiple interactions

sodium nitrate inhibits the reaction [Diclofenac results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mucin 6, oligomeric mucus/gel-forming

increases expression

sodium nitrate results in increased expression of MUC6 mRNA

NCBI chr 1:196,726,678...196,764,842
Ensembl chr 1:196,726,807...196,764,842

G

myosin heavy chain 6

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of MYH6 protein]

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin light chain 2

multiple interactions

[sodium nitrate co-treated with Doxorubicin] results in decreased expression of MYL2 protein; sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of MYL2 protein]

NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983

G

myosin light chain 3

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of MYL3 protein]

NCBI chr 8:110,738,669...110,744,814
Ensembl chr 8:110,738,661...110,744,816

G

myozenin 2

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of MYOZ2 protein]

NCBI chr 2:211,141,463...211,168,187
Ensembl chr 2:211,141,463...211,168,221

G

nitric oxide synthase 2

multiple interactions

sodium nitrate inhibits the reaction [Diclofenac results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

sodium nitrate inhibits the reaction [NOS3 gene mutant form results in increased abundance of Triglycerides]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

pyruvate kinase M1/2

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of PKM protein]

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

peroxiredoxin 3

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of PRDX3 protein]

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

peroxiredoxin 5

increases expression
multiple interactions

sodium nitrate results in increased expression of PRDX5 protein
sodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of PRDX5 protein]

PMID:21251210 PMID:22484629

NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268

G

glycogen phosphorylase B

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of PYGB protein]

NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553

G

glycogen phosphorylase, muscle associated

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of PYGM protein]

NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368

G

solute carrier family 16 member 2

increases expression

sodium nitrate results in increased expression of SLC16A2 mRNA

NCBI chr X:68,725,365...68,848,572
Ensembl chr X:68,723,261...68,848,771

G

solute carrier family 26 member 4

affects expression

sodium nitrate affects the expression of SLC26A4 mRNA

NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703

G

superoxide dismutase 2

multiple interactions
increases expression

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of SOD2 protein]
sodium nitrate results in increased expression of SOD2 mRNA

PMID:21251210 PMID:34409734

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sarcalumenin

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of SRL protein]

NCBI chr10:11,033,976...11,078,103
Ensembl chr10:11,034,035...11,078,101

G

succinate-CoA ligase GDP-forming subunit beta

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of SUCLG2 protein]

NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170

G

thyroglobulin

decreases expression

sodium nitrate results in decreased expression of TG mRNA

NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210

G

thyroid peroxidase

increases expression

sodium nitrate results in increased expression of TPO mRNA

NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199

G

ubiquinol-cytochrome c reductase core protein 1

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of UQCRC1 protein]

NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480

G

xanthine dehydrogenase

increases metabolic processing

XDH protein results in increased metabolism of sodium nitrate

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

multiple interactions

sodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of YWHAZ protein]

NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668

sodium nitrite

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
decreases activity

[Hypochlorous Acid co-treated with Sodium Nitrite] results in decreased activity of ACHE protein
Sodium Nitrite results in decreased activity of ACHE protein

PMID:12414318 PMID:26231821

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acid phosphatase 1

increases activity

Sodium Nitrite results in increased activity of ACP1 protein

NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021

G

actin alpha 2, smooth muscle

increases expression
multiple interactions

Sodium Nitrite results in increased expression of ACTA2 protein
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

AKT serine/threonine kinase 1

increases expression
multiple interactions

Sodium Nitrite results in increased expression of AKT1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

adenosine monophosphate deaminase 3

increases activity

Sodium Nitrite results in increased activity of AMPD3 protein

NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887

G

amyloid beta precursor protein

multiple interactions

[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Sodium Nitrite results in increased expression of BAX mRNA; Sodium Nitrite results in increased expression of BAX protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]

PMID:28000380 PMID:28266762 PMID:28833918

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Sodium Nitrite results in decreased expression of BCL2 mRNA; Sodium Nitrite results in decreased expression of BCL2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]

PMID:28000380 PMID:28266762 PMID:28833918

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

increases activity
multiple interactions

Sodium Nitrite results in increased activity of CASP3 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases activity
increases activity

Sodium Nitrite results in decreased activity of CAT protein
Sodium Nitrite results in increased activity of CAT protein

PMID:26231821 PMID:31476334

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin B1

increases expression

Sodium Nitrite results in increased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

Cd68 molecule

increases expression
multiple interactions

Sodium Nitrite results in increased expression of CD68 protein
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of CD68 protein]

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

checkpoint kinase 1

increases expression

Sodium Nitrite results in increased expression of CHEK1 protein

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

C-reactive protein

multiple interactions
increases expression

Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein]

PMID:28266762 PMID:28833918

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

glucose-6-phosphate dehydrogenase

decreases activity

Sodium Nitrite results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glutamic--pyruvic transaminase

multiple interactions
increases activity

Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione-disulfide reductase

decreases activity

Sodium Nitrite results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

H2A.X variant histone

increases expression

Sodium Nitrite results in increased expression of H2AX protein modified form

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

helicase, lymphoid specific

increases expression

Sodium Nitrite results in increased expression of HELLS protein

NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844

G

hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions

Sodium Nitrite results in increased expression of HIF1A protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]

PMID:28000380 PMID:28266762

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

interleukin 1 beta

increases expression
multiple interactions
increases secretion

Sodium Nitrite results in increased expression of IL1B mRNA
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of IL1B protein]
Sodium Nitrite results in increased secretion of IL1B protein

PMID:16581224 PMID:33030083

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

increases expression

Sodium Nitrite results in increased expression of IL1RL1 protein

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 6

increases secretion
increases expression
multiple interactions

Sodium Nitrite results in increased secretion of IL6 protein
Sodium Nitrite results in increased expression of IL6 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]

PMID:16581224 PMID:28266762

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

lactate dehydrogenase B

increases activity

Sodium Nitrite results in increased activity of LDHB protein

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

minichromosome maintenance complex component 3

increases expression

Sodium Nitrite results in increased expression of MCM3 protein

NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314

G

NFKB inhibitor alpha

multiple interactions
decreases expression

Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

RAD51 associated protein 1

increases expression

Sodium Nitrite results in increased expression of RAD51AP1 protein

NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524

G

SMAD family member 2

increases expression
multiple interactions

Sodium Nitrite results in increased expression of SMAD2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]

PMID:28000380 PMID:28266762

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

stathmin 1

increases expression

Sodium Nitrite results in increased expression of STMN1 protein

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

transforming growth factor, beta 1

increases expression
multiple interactions

Sodium Nitrite results in increased expression of TGFB1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]

PMID:28266762 PMID:33030083

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

increases expression
multiple interactions
increases secretion

Sodium Nitrite results in increased expression of TNF mRNA
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]
Sodium Nitrite results in increased secretion of TNF protein

PMID:16581224 PMID:28266762 PMID:28833918 PMID:33030083

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular endothelial growth factor A

increases expression
multiple interactions

Sodium Nitrite results in increased expression of VEGFA protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

zinc nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-X-C motif chemokine ligand 3

increases expression
multiple interactions

zinc nitrate results in increased expression of CXCL1 mRNA
MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of CXCL1 mRNA]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

glucose-6-phosphate dehydrogenase

decreases activity

zinc nitrate results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

interleukin 6

multiple interactions
increases expression

MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

MYD88, innate immune signal transduction adaptor

multiple interactions

MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of CCL2 mRNA]; MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of CXCL1 mRNA]; MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of IL6 mRNA]; MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of TNF mRNA]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

tumor necrosis factor

multiple interactions
increases expression

MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of TNF mRNA]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19880
chemical entity	19878
atom	19878
nonmetal atom	19800
nitrogen atom	18979
nitrogen molecular entity	18979
nitrogen oxoanion	378
aci-nitroethane(1-)	0
aminooxidanide	0
hyponitrite(1-)	0
hyponitrite(2-)	0
nitrate +	363
nitrite +	32
peroxynitrate	0
peroxynitrite	0
Path 2
Term	Annotations
CHEBI ontology	19880
subatomic particle	19878
composite particle	19878
hadron	19878
baryon	19878
nucleon	19878
atomic nucleus	19878
atom	19878
main group element atom	19817
p-block element atom	19817
chalcogen	19569
chalcogen molecular entity	19569
oxygen molecular entity	19541
oxide	12870
oxoanion	10449
pnictogen oxoanion	6497
nitrogen oxoanion	378
aci-nitroethane(1-)	0
aminooxidanide	0
hyponitrite(1-)	0
hyponitrite(2-)	0
nitrate +	363
nitrite +	32
peroxynitrate	0
peroxynitrite	0

paths to the root