organoheteryl group - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	organoheteryl group	go back to main search page
Accession:	CHEBI:33456	browse the term
Definition:	A univalent group containing carbon which has its free valence at an atom other than carbon.
Synonyms:	exact_synonym:	organoheteryl groups
	related_synonym:	groupe organoheteryle; grupo organoheterilo; grupos organoheterilo; organoelement group

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Genes (35)

thioridazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

Thioridazine results in decreased expression of AP1S1 mRNA

PMID:15342952 PMID:17175557

NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713

G

N-acylsphingosine amidohydrolase 1

increases expression

Thioridazine results in increased expression of ASAH1 mRNA

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

Thioridazine results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

caspase 3

increases activity

Thioridazine results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin D1

decreases expression

Thioridazine results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cell division cycle 25A

increases phosphorylation

Thioridazine results in increased phosphorylation of CDC25A protein

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cyclin-dependent kinase 4

decreases expression

Thioridazine results in decreased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

increases expression

Thioridazine results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

increases expression

Thioridazine results in increased expression of CDKN2A protein

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

carboxylesterase 1D

multiple interactions

Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

corticotropin releasing hormone

decreases expression

Thioridazine results in decreased expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP1A2 protein results in increased metabolism of and results in increased activity of Thioridazine

PMID:19482014 PMID:23397584

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
decreases activity

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
Thioridazine results in decreased activity of CYP2C19 protein

PMID:15135088 PMID:23397584

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazine

PMID:19482014 PMID:23397584

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

Thioridazine results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases activity

[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
Thioridazine results in decreased activity of CYP3A4 protein

PMID:15135088 PMID:23397584

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

DEPP autophagy regulator 1

increases expression

Thioridazine results in increased expression of DEPP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation

Thioridazine results in decreased phosphorylation of EIF4EBP1 protein

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

fatty acid binding protein 1

increases expression

Thioridazine results in increased expression of FABP1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

fibronectin type III domain containing 4

increases expression

Thioridazine results in increased expression of FNDC4 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

glycerophosphodiester phosphodiesterase domain containing 3

increases expression

Thioridazine results in increased expression of GDPD3 mRNA

NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063

G

hepsin

increases expression

Thioridazine results in increased expression of HPN mRNA

NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811

G

inhibin subunit beta E

increases expression

Thioridazine results in increased expression of INHBE mRNA

PMID:15342952 PMID:17175557

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

Thioridazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Thioridazine results in decreased activity of KCNH2 protein

PMID:15671647 PMID:16278312 PMID:21158687 PMID:24052561

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

lanosterol synthase

increases expression

Thioridazine results in increased expression of LSS mRNA

PMID:15342952 PMID:17175557

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Thioridazine results in increased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear protein 1, transcriptional regulator

increases expression

Thioridazine results in increased expression of NUPR1 mRNA

PMID:15342952 PMID:17175557

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

phytanoyl-CoA 2-hydroxylase

increases expression

Thioridazine results in increased expression of PHYH mRNA

NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409

G

prolactin

increases expression

Thioridazine results in increased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

serpin family A member 3N

increases expression

Thioridazine results in increased expression of SERPINA3 mRNA

PMID:15342952 PMID:17175557

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

solute carrier family 22 member 2

multiple interactions

Thioridazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 2 member 3

decreases expression

Thioridazine results in decreased expression of SLC2A3 mRNA

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

transgelin

decreases expression

Thioridazine results in decreased expression of TAGLN mRNA

PMID:15342952 PMID:17175557

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

tumor protein p53

affects activity

Thioridazine affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

WD repeat domain, phosphoinositide interacting 1

increases expression

Thioridazine results in increased expression of WIPI1 mRNA

PMID:15342952 PMID:17175557

NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19874
chemical entity	19872
group	19825
organic group	18977
organic univalent group	18674
organoheteryl group	35
(C-hydroxycarbonimidoyl)amino group	0
(p-hydroxyphenyl)glycinamido group	0
2-(aminomethylidene)hydrazinyl group	0
4-arsonophenyldiazenyl group	0
C-aminocarbonohydrazonoyl group	0
C-terminal L-Ala-L-Leu-L-valinamide-N-CH=CH-S residue	0
L-homoserine lactone group	0
N-oxindolyl group	0
O-(N-acetyl-alpha-D-galactosaminyl)-L-threonino group	0
\{5-[(3-azidopropyl)amino]-5-oxopentanoyl\}amino group	0
acetimidamido group	0
acetimidoyl group	0
acetylhydrazino group	0
alkylamino group +	0
alkyloxy group +	0
benzoyloxy group	0
benzyloxy group +	0
carbamothioyl group	0
carbamoylamino group	0
carbamoylcarbamoyl group	0
cyanato group	0
guanidino group +	0
methylsulfanyl group +	35
organosilyl group +	0
oxaloamino group	0
oxalooxy group	0
oxalosulfanyl group	0
oxamoyl group	0
oxamoylamino group	0
phenylazo groups +	0
phenylsulfanyl group +	0
quininyl group	0
thiocyanato group	0
triflate group +	0
Path 2
Term	Annotations
CHEBI ontology	19874
subatomic particle	19872
composite particle	19872
hadron	19872
baryon	19872
nucleon	19872
atomic nucleus	19872
atom	19872
group	19825
organic group	18977
organic univalent group	18674
organoheteryl group	35
(C-hydroxycarbonimidoyl)amino group	0
(p-hydroxyphenyl)glycinamido group	0
2-(aminomethylidene)hydrazinyl group	0
4-arsonophenyldiazenyl group	0
C-aminocarbonohydrazonoyl group	0
C-terminal L-Ala-L-Leu-L-valinamide-N-CH=CH-S residue	0
L-homoserine lactone group	0
N-oxindolyl group	0
O-(N-acetyl-alpha-D-galactosaminyl)-L-threonino group	0
\{5-[(3-azidopropyl)amino]-5-oxopentanoyl\}amino group	0
acetimidamido group	0
acetimidoyl group	0
acetylhydrazino group	0
alkylamino group +	0
alkyloxy group +	0
benzoyloxy group	0
benzyloxy group +	0
carbamothioyl group	0
carbamoylamino group	0
carbamoylcarbamoyl group	0
cyanato group	0
guanidino group +	0
methylsulfanyl group +	35
organosilyl group +	0
oxaloamino group	0
oxalooxy group	0
oxalosulfanyl group	0
oxamoyl group	0
oxamoylamino group	0
phenylazo groups +	0
phenylsulfanyl group +	0
quininyl group	0
thiocyanato group	0
triflate group +	0

paths to the root