CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: radon atom
Accession: CHEBI:33314
browse the term
Definition: A noble gas atom that has formula Rn.
Synonyms: related_synonym: 86Rn; Formula=Rn; InChI=1S/Rn; InChIKey=SYUHGPGVQRZVTB-UHFFFAOYSA-N; Rn; SMILES=[Rn]; niton; radium emanation; radon
xref: CAS:10043-92-2; Gmelin:16242
xref_mesh: MESH:D011886
xref: WebElements:Rn
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Acta2
actin alpha 2, smooth muscle
increases expression multiple interactions
ISO
Radon results in increased expression of ACTA2 mRNA; Radon results in increased expression of ACTA2 protein MK 2206 inhibits the reaction [Radon results in increased expression of ACTA2 protein]; ridaforolimus inhibits the reaction [Radon results in increased expression of ACTA2 protein]
CTD
PMID:32949624
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Ar
androgen receptor
increases mutagenesis
ISO
Radon results in increased mutagenesis of AR exon
CTD
PMID:30008631
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Casp3
caspase 3
multiple interactions increases cleavage
ISO
Melatonin inhibits the reaction [Radon results in increased cleavage of CASP3 protein]
CTD
PMID:33107683
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cdh1
cadherin 1
multiple interactions decreases expression
ISO
MK 2206 inhibits the reaction [Radon results in decreased expression of CDH1 protein]; ridaforolimus inhibits the reaction [Radon results in decreased expression of CDH1 protein] Radon results in decreased expression of CDH1 mRNA; Radon results in decreased expression of CDH1 protein
CTD
PMID:32949624
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdh2
cadherin 2
increases expression multiple interactions
ISO
Radon results in increased expression of CDH2 protein MK 2206 inhibits the reaction [Radon results in increased expression of CDH2 protein]; ridaforolimus inhibits the reaction [Radon results in increased expression of CDH2 protein]
CTD
PMID:32949624
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
increases methylation
ISO
Radon results in increased methylation of CDKN2A promoter
CTD
PMID:16902270
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Chd4
chromodomain helicase DNA binding protein 4
increases mutagenesis
ISO
Radon results in increased mutagenesis of CHD4 exon
CTD
PMID:30008631
NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541
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Ctnnb1
catenin beta 1
increases expression
ISO
Radon results in increased expression of CTNNB1 protein
CTD
PMID:32949624
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Fn1
fibronectin 1
increases expression multiple interactions
ISO
Radon results in increased expression of FN1 mRNA; Radon results in increased expression of FN1 protein MK 2206 inhibits the reaction [Radon results in increased expression of FN1 protein]; ridaforolimus inhibits the reaction [Radon results in increased expression of FN1 protein]
CTD
PMID:32949624
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Gsk3b
glycogen synthase kinase 3 beta
decreases expression
ISO
Radon results in decreased expression of GSK3B protein
CTD
PMID:32949624
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Gstm1
glutathione S-transferase mu 1
increases response to substance
ISO
GSTM1 gene mutant form results in increased susceptibility to Radon
CTD
PMID:24852519
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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Gstt1
glutathione S-transferase theta 1
increases response to substance
ISO
GSTT1 gene mutant form results in increased susceptibility to Radon
CTD
PMID:24852519
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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Hif1a
hypoxia inducible factor 1 subunit alpha
increases expression
ISO
Radon results in increased expression of HIF1A protein
CTD
PMID:32198912
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hk2
hexokinase 2
increases expression
ISO
Radon results in increased expression of HK2 protein
CTD
PMID:32198912
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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Il6
interleukin 6
affects response to substance
ISO
IL6 promoter SNP affects the susceptibility to Radon
CTD
PMID:26372664
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
increases expression multiple interactions
ISO
Radon results in increased expression of MAP1LC3B protein Melatonin inhibits the reaction [Radon results in increased expression of MAP1LC3B protein]
CTD
PMID:33107683
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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Mgmt
O-6-methylguanine-DNA methyltransferase
increases methylation
ISO
Radon results in increased methylation of MGMT promoter
CTD
PMID:16902270
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Mir1249
microRNA 1249
decreases expression
ISO
Radon results in decreased expression of MIR1249 mRNA
CTD
PMID:23294299
NCBI chr 7:116,075,593...116,075,712
Ensembl chr 7:116,075,593...116,075,712
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Mir18a
microRNA 18a
affects expression
ISO
Radon affects the expression of MIR18A mRNA
CTD
PMID:23294299
NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
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Mir190
microRNA 190
increases expression
ISO
Radon results in increased expression of MIR190A mRNA
CTD
PMID:23294299
NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071
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Mir208a
microRNA 208a
decreases expression
ISO
Radon results in decreased expression of MIR208A mRNA
CTD
PMID:23294299
NCBI chr15:28,425,570...28,425,652
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Mir375
microRNA 375
affects expression
ISO
Radon affects the expression of MIR375 mRNA
CTD
PMID:23294299
NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
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Mir489
microRNA 489
decreases expression
ISO
Radon results in decreased expression of MIR489 mRNA
CTD
PMID:23294299
NCBI chr 4:31,693,355...31,693,460
Ensembl chr 4:31,693,355...31,693,460
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Mir494
microRNA 494
affects expression
ISO
Radon affects the expression of MIR494 mRNA
CTD
PMID:23294299
NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793
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Mir665
microRNA 665
affects expression
ISO
Radon affects the expression of MIR665 mRNA
CTD
PMID:23294299
NCBI chr 6:128,539,440...128,539,533
Ensembl chr 6:128,539,440...128,539,533
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Mir711
microRNA 711
affects expression
ISO
Radon affects the expression of MIR711 mRNA
CTD
PMID:23294299
NCBI chr 8:109,621,975...109,622,042
Ensembl chr 8:109,621,975...109,622,042
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Mir874
microRNA 874
decreases expression
ISO
Radon results in decreased expression of MIR874 mRNA
CTD
PMID:23294299
NCBI chr17:6,620,649...6,620,724
Ensembl chr17:6,620,649...6,620,724
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Mir98
microRNA 98
increases expression
ISO
Radon results in increased expression of MIR98 mRNA
CTD
PMID:23294299
NCBI chr X:20,981,235...20,981,342
Ensembl chr X:20,981,235...20,981,342
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Mirlet7c1
microRNA let-7c-1
increases expression
ISO
Radon results in increased expression of MIRLET7C mRNA
CTD
PMID:23294299
NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265
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Mmp2
matrix metallopeptidase 2
increases expression
ISO
Radon results in increased expression of MMP2 protein
CTD
PMID:32949624
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mtor
mechanistic target of rapamycin kinase
increases expression multiple interactions
ISO
Radon results in increased expression of MTOR protein modified form MK 2206 inhibits the reaction [Radon results in increased expression of MTOR protein modified form]; ridaforolimus inhibits the reaction [Radon results in increased expression of MTOR protein modified form]
CTD
PMID:32949624
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression
ISO
Radon results in increased expression of NFE2L2 protein
CTD
PMID:33107683
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
Radon results in increased expression of NQO1 protein
CTD
PMID:33107683
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions decreases expression
ISO
Melatonin inhibits the reaction [Radon results in decreased expression of PTGS2 mRNA]
CTD
PMID:33107683
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Sdha
succinate dehydrogenase complex flavoprotein subunit A
decreases expression
ISO
Radon results in decreased expression of SDHA protein
CTD
PMID:32198912
NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
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Snai1
snail family transcriptional repressor 1
multiple interactions increases expression
ISO
MK 2206 inhibits the reaction [Radon results in increased expression of SNAI1 protein]; ridaforolimus inhibits the reaction [Radon results in increased expression of SNAI1 protein]
CTD
PMID:32949624
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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Sqstm1
sequestosome 1
increases expression multiple interactions
ISO
Radon results in increased expression of SQSTM1 protein Melatonin inhibits the reaction [Radon results in increased expression of SQSTM1 protein]
CTD
PMID:33107683
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Timp2
TIMP metallopeptidase inhibitor 2
increases expression
ISO
Radon results in increased expression of TIMP2 protein
CTD
PMID:32949624
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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Tsc2
TSC complex subunit 2
increases mutagenesis
ISO
Radon results in increased mutagenesis of TSC2 exon
CTD
PMID:30008631
NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
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Vim
vimentin
increases expression multiple interactions
ISO
Radon results in increased expression of VIM protein Radon results in increased expression of VIM mRNA; Radon results in increased expression of VIM protein MK 2206 inhibits the reaction [Radon results in increased expression of VIM protein]; ridaforolimus inhibits the reaction [Radon results in increased expression of VIM protein]
CTD
PMID:32949624
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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