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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-tocotrienol
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Accession:CHEBI:33270 term browser browse the term
Definition:A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a farnesyl chain at position 2. It has been found in palm oil derived from Elaeis guineensis.
Synonyms:exact_synonym: (2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-chromen-6-ol
 related_synonym: (2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-1-benzopyran-6-ol;   Formula=C29H44O2;   InChI=1S/C29H44O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h12,14,16,30H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1;   InChIKey=RZFHLOLGZPDCHJ-XZXLULOTSA-N;   SMILES=CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1;   zeta1-tocopherol
 alt_id: CHEBI:35062
 xref: Beilstein:45723;   Beilstein:5484296;   CAS:1721-51-3;   Chemspider:4445512;   FooDB:FDB002434;   HMDB:HMDB0006327;   KEGG:C14153;   KNApSAcK:C00035044;   LIPID_MAPS_instance:LMPR02020054
 xref_mesh: MESH:C082032
 xref: MetaCyc:CPD-15836;   PMCID:PMC7259054;   PMID:11160563;   PMID:12030315;   PMID:12521598;   PMID:12524170;   PMID:12566479;   PMID:12739983;   PMID:12788481;   PMID:15527824;   PMID:16166580;   PMID:16257640;   PMID:16616508;   PMID:16771695;   PMID:16923160;   PMID:17331802;   PMID:20028458;   PMID:20823491;   PMID:22013739;   PMID:22252050;   PMID:24013375;   PMID:30110365;   PMID:31905614;   PMID:7808307;   Patent:EP2362875;   Patent:US2010105930;   Patent:WO2010051277;   Reaxys:5484296;   Wikipedia:Alpha-Tocotrienol


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alpha-tocotrienol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO tocotrienol, alpha results in increased expression of ABCB1 CTD PMID:15269186 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO tocotrienol, alpha inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; tocotrienol, alpha inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]
tocotrienol, alpha results in increased expression of CYP3A4		 CTD PMID:15269186 PMID:31102695 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance
multiple interactions		 ISO CYP3A5 gene polymorphism affects the susceptibility to tocotrienol, alpha
tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]		 CTD PMID:31102695 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO GSTM1 gene polymorphism affects the susceptibility to [Ascorbic Acid co-treated with tocotrienol, alpha] CTD PMID:15668500 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO tocotrienol, alpha inhibits the reaction [NR1I2 protein binds to NCOR1 protein] CTD PMID:15269186 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO tocotrienol, alpha binds to and results in increased activity of NR1I2 protein; tocotrienol, alpha inhibits the reaction [NR1I2 protein binds to NCOR1 protein] CTD PMID:15269186 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO tocotrienol, alpha results in increased expression of UGT1A1 CTD PMID:15269186 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        inhibitor 18938
          ferroptosis inhibitor 8105
            alpha-tocotrienol 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            organic molecule 19755
                              organic cyclic compound 19545
                                organic heterocyclic compound 18906
                                  oxacycle 17904
                                    benzopyran 11976
                                      1-benzopyran 11730
                                        chromanes 4029
                                          chromanol 1874
                                            chroman-6-ol 1874
                                              tocol 266
                                                tocotrienol 43
                                                  alpha-tocotrienol 7
paths to the root