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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:D-gluconic acid
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Accession:CHEBI:33198 term browser browse the term
Definition:A gluconic acid having D-configuration.
Synonyms:related_synonym: (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid;   D-Gluconsaeure;   D-Glukonsaeure;   D-gluco-Hexonic acid;   Dextronic acid;   Formula=C6H12O7;   GLUCONIC ACID;   Glycogenic acid;   Hexonic acid;   InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/t2-,3-,4+,5-/m1/s1;   InChIKey=RGHNJXZEOKUKBD-SQOUGZDYSA-N;   Maltonic acid;   SMILES=OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O
 alt_id: CHEBI:20986;   CHEBI:4157;   CHEBI:42715
 xref: CAS:526-95-4;   Drug_Central:3264;   Gmelin:83545;   HMDB:HMDB0000625;   KEGG:C00257;   KNApSAcK:C00007303
 xref_mesh: MESH:C030691
 xref: MetaCyc:GLUCONATE;   PDBeChem:GCO;   PMID:11777404;   PMID:17439666;   PMID:19577953;   PMID:20222845;   PMID:21086198;   PMID:21424687;   PMID:21819772;   PMID:22352719;   PMID:22541639;   PMID:22688246;   PMID:22770225;   PMID:24024763;   Reaxys:1726055;   Wikipedia:Gluconic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:18391;   is_enantiomer_of CHEBI:86359


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D-gluconic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of ALDH1A2 mRNA CTD PMID:16556975 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of gluconic acid; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of gluconic acid] CTD PMID:39172838 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of ARNT2 mRNA CTD PMID:16556975 NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153 		JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of ATP6V1F mRNA CTD PMID:16556975 NCBI chr 4:58,067,666...58,070,628 JBrowse link
G Casp3 caspase 3 multiple interactions ISO gluconic acid promotes the reaction [Zinc Sulfate inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]] CTD PMID:27017951 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [gluconic acid co-treated with Zinc Sulfate] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA] CTD PMID:27017951 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cblb Cbl proto-oncogene B decreases expression EXP gluconic acid results in decreased expression of CBLB mRNA CTD PMID:16556975 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 increases response to substance ISO CLCN3 protein results in increased susceptibility to gluconic acid CTD PMID:12843258 NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression EXP gluconic acid results in increased expression of CRHR1 mRNA CTD PMID:16556975 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of CSF1R mRNA CTD PMID:16556975 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of CYP4A8 mRNA CTD PMID:16556975 NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase decreases expression EXP gluconic acid results in decreased expression of FYN mRNA CTD PMID:16556975 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:30031400 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of GRK2 mRNA CTD PMID:16556975 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 increases expression EXP gluconic acid results in increased expression of HCN4 mRNA CTD PMID:16556975 NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA] CTD PMID:30031400 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hoxa1 homeobox A1 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of HOXA1 mRNA CTD PMID:16556975 NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504 		JBrowse link
G Kcnc1 potassium voltage-gated channel subfamily C member 1 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of KCNC1 mRNA CTD PMID:16556975 NCBI chr 1:96,902,953...96,944,744
Ensembl chr 1:96,902,953...96,944,744 		JBrowse link
G Kif3c kinesin family member 3C increases expression EXP gluconic acid results in increased expression of KIF3C mRNA CTD PMID:16556975 NCBI chr 6:26,367,092...26,406,033
Ensembl chr 6:26,366,531...26,406,130 		JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in decreased expression of LCAT mRNA] CTD PMID:30031400 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231 		JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of LPL mRNA CTD PMID:16556975 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Mdh1 malate dehydrogenase 1 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of MDH1 mRNA CTD PMID:16556975 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mdh2 malate dehydrogenase 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of MDH2 mRNA CTD PMID:16556975 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO gluconic acid inhibits the reaction [Zinc Sulfate promotes the reaction [Aflatoxin B1 results in increased expression of MT1A mRNA]] CTD PMID:27017951 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO gluconic acid inhibits the reaction [Zinc Sulfate promotes the reaction [Aflatoxin B1 results in increased expression of MT2A mRNA]] CTD PMID:27017951 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of NR1D2 mRNA CTD PMID:16556975 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] affects the reaction [Dietary Fats results in increased expression of NR1H3 mRNA] CTD PMID:30031400 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PAK1 mRNA CTD PMID:16556975 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PGAP2 mRNA CTD PMID:16556975 NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PRKAR1A mRNA CTD PMID:16556975 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PRKCA mRNA CTD PMID:16556975 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of gluconic acid; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of gluconic acid] CTD PMID:39172838 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Ptges prostaglandin E synthase multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PTGES mRNA CTD PMID:16556975 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of PTPN2 mRNA CTD PMID:16556975 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of RARA mRNA CTD PMID:16556975 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rxrg retinoid X receptor gamma multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of RXRG mRNA CTD PMID:16556975 NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167 		JBrowse link
G Sema6c semaphorin 6C multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SEMA6C mRNA CTD PMID:16556975 NCBI chr 2:182,733,635...182,750,066
Ensembl chr 2:182,737,474...182,746,856 		JBrowse link
G Sirpa signal-regulatory protein alpha multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SIRPA mRNA CTD PMID:16556975 NCBI chr 3:116,819,730...116,858,099
Ensembl chr 3:116,819,726...116,858,098 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SLC15A2 mRNA CTD PMID:16556975 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO gluconic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO gluconic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] CTD PMID:12472777 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SLC22A8 mRNA CTD PMID:16556975 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc32a1 solute carrier family 32 member 1 decreases expression EXP gluconic acid results in decreased expression of SLC32A1 mRNA CTD PMID:16556975 NCBI chr 3:147,267,373...147,271,842
Ensembl chr 3:147,267,373...147,271,844 		JBrowse link
G Slc6a8 solute carrier family 6 member 8 increases expression EXP gluconic acid results in increased expression of SLC6A8 mRNA CTD PMID:16556975 NCBI chr  X:151,384,675...151,393,979
Ensembl chr  X:151,384,675...151,393,979 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [gluconic acid co-treated with Zinc Sulfate] promotes the reaction [Aflatoxin B1 results in increased expression of SOD1 mRNA] CTD PMID:27017951 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [[gluconic acid results in increased abundance of Magnesium] co-treated with [Sodium Selenite results in increased abundance of Selenium]] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:30031400 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Sstr3 somatostatin receptor 3 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SSTR3 mRNA CTD PMID:16556975 NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769 		JBrowse link
G Tas2r106 taste receptor, type 2, member 106 decreases expression EXP gluconic acid results in decreased expression of TAS2R10 mRNA CTD PMID:16556975 NCBI chr 4:165,313,210...165,314,133
Ensembl chr 4:165,313,210...165,314,133 		JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of UBE2I mRNA CTD PMID:16556975 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of VAMP2 mRNA CTD PMID:16556975 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809 		JBrowse link
G Vax2 ventral anterior homeobox 2 multiple interactions EXP [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of VAX2 mRNA CTD PMID:16556975 NCBI chr 4:116,195,528...116,219,597
Ensembl chr 4:116,195,528...116,219,594 		JBrowse link
G Vps52 VPS52 subunit of GARP complex increases expression EXP gluconic acid results in increased expression of VPS52 mRNA CTD PMID:16556975 NCBI chr20:4,920,715...4,931,685
Ensembl chr20:4,860,843...4,931,665 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression EXP gluconic acid results in increased expression of WEE1 mRNA CTD PMID:16556975 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      chemical role 19479
        ligand 6755
          chelator 6742
            D-gluconic acid 53
              2,5-didehydro-D-gluconic acid 0
              2-amino-2-deoxy-D-gluconic acid + 0
              2-dehydro-3-deoxy-D-gluconic acid 0
              2-dehydro-D-gluconic acid + 0
              3-dehydro-2-deoxy-D-gluconic acid 0
              3-dehydro-D-gluconic acid 0
              5-dehydro-D-gluconic acid 0
              6-deoxy-6-sulfo-D-gluconic acid 0
              D-glucono-1,4-lactone + 0
              D-glucono-1,5-lactone + 0
              N-acetyl-D-glucosaminic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      monocarboxylic acid 18004
                                        aldonic acid 61
                                          hexonic acid 53
                                            gluconic acid 53
                                              D-gluconic acid 53
                                                2,5-didehydro-D-gluconic acid 0
                                                2-amino-2-deoxy-D-gluconic acid + 0
                                                2-dehydro-3-deoxy-D-gluconic acid 0
                                                2-dehydro-D-gluconic acid + 0
                                                3-dehydro-2-deoxy-D-gluconic acid 0
                                                3-dehydro-D-gluconic acid 0
                                                5-dehydro-D-gluconic acid 0
                                                6-deoxy-6-sulfo-D-gluconic acid 0
                                                D-glucono-1,4-lactone + 0
                                                D-glucono-1,5-lactone + 0
                                                N-acetyl-D-glucosaminic acid 0
paths to the root