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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:baccatin III
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Accession:CHEBI:32898 term browser browse the term
Definition:A tetracyclic diterpenoid isolated from plant species of the genus Taxus.
Synonyms:exact_synonym: 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate
 related_synonym: Formula=C31H38O11;   InChI=1S/C31H38O11/c1-15-19(34)13-31(38)26(41-27(37)18-10-8-7-9-11-18)24-29(6,20(35)12-21-30(24,14-39-21)42-17(3)33)25(36)23(40-16(2)32)22(15)28(31,4)5/h7-11,19-21,23-24,26,34-35,38H,12-14H2,1-6H3/t19-,20-,21+,23+,24-,26-,29+,30-,31+/m0/s1;   InChIKey=OVMSOCFBDVBLFW-VHLOTGQHSA-N;   SMILES=[H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](O)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C;   [2aR-(2aalpha,4beta,4abeta,6beta,9alpha,11alpha,12alpha,12aalpha,12balpha)]-6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one
 alt_id: CHEBI:13870;   CHEBI:29546
 xref: CAS:27548-93-2;   KEGG:C11900;   PMID:23265441;   PMID:24403190;   PMID:24696551;   Reaxys:1445625;   Wikipedia:Baccatin_III


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6-hydroxypaclitaxel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases chemical synthesis ISO CYP2C8 protein results in increased chemical synthesis of 6-hydroxytaxol CTD PMID:12401345
cabazitaxel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1s1 AKT1 substrate 1 decreases expression ISO cabazitaxel results in decreased expression of AKT1S1 protein CTD PMID:32525019 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO cabazitaxel results in increased expression of BAX mRNA CTD PMID:33380212 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO cabazitaxel results in decreased expression of BCL2 mRNA CTD PMID:33380212 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases expression ISO cabazitaxel results in increased expression of CASP3 mRNA CTD PMID:33380212 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Foxo3 forkhead box O3 affects expression ISO cabazitaxel affects the expression of FOXO3 protein CTD PMID:32525019 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
multiple interactions		 ISO cabazitaxel results in increased expression of RELA mRNA
cabazitaxel affects the expression of and affects the localization of RELA protein		 CTD PMID:33380212 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO cabazitaxel results in decreased expression of TLR4 mRNA; cabazitaxel results in decreased expression of TLR4 protein CTD PMID:33380212 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
paclitaxel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP binding cassette subfamily A member 5 increases expression ISO Paclitaxel results in increased expression of ABCA5 mRNA CTD PMID:20737486 NCBI chr10:95,240,159...95,309,195
Ensembl chr10:95,240,154...95,308,976 		JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 increases expression ISO Paclitaxel results in increased expression of ABCA7 mRNA CTD PMID:20737486 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Paclitaxel results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects metabolic processing
multiple interactions
increases expression
affects uptake
increases export
decreases response to substance
increases activity
increases transport
decreases uptake
increases response to substance
affects response to substance		 ISO ABCB1 gene polymorphism affects the metabolism of Paclitaxel
[Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Calcitriol promotes the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]
ABCB1A protein affects the uptake of Paclitaxel
ABCB1 protein results in increased export of Paclitaxel
ABCB1 mRNA results in decreased susceptibility to Paclitaxel; ABCB1 protein results in decreased susceptibility to Paclitaxel
6-OH-BDE-47 inhibits the reaction [ABCB1 protein results in increased export of Paclitaxel]; [Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; [Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA; [Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]] which results in decreased susceptibility to Paclitaxel; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; [Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [CXCL8 results in increased expression of ABCB1 mRNA] which results in decreased susceptibility to Paclitaxel; [CXCL8 results in increased expression of ABCB1 protein] which results in decreased susceptibility to Paclitaxel; [Cyclosporine results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; [Paclitaxel co-treated with IL6 protein] results in increased expression of ABCB1 protein; [Paclitaxel results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Cisplatin; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Fluorouracil; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Vincristine; [valspodar results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; [Verapamil results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; ABCB1 protein affects the reaction [acetochlor results in increased susceptibility to Paclitaxel]; ABCB1 protein affects the reaction [alachlor results in increased susceptibility to Paclitaxel]; ABCB1 protein affects the reaction [metolachlor results in increased susceptibility to Paclitaxel]; ABCB1 protein results in increased export of and affects the susceptibility to Paclitaxel; Calcitriol inhibits the reaction [[Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Calcitriol inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]; CEP 33779 inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; cinchonine analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; cinchonine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Crizotinib inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; HIF1A protein affects the reaction [[Paclitaxel co-treated with IL6 protein] results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; NR1I2 protein promotes the reaction [Paclitaxel results in increased expression of and results in increased activity of ABCB1 protein]; Paclitaxel results in increased expression of and binds to and results in increased activity of ABCB1 protein; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; propiconazole inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]
Paclitaxel results in increased expression of ABCB1 mRNA; Paclitaxel results in increased expression of ABCB1 protein
Paclitaxel results in increased activity of ABCB1 protein
ABCB1 protein results in decreased uptake of Paclitaxel
ABCB1 mRNA results in increased susceptibility to Paclitaxel
ABCB1 gene SNP affects the susceptibility to Paclitaxel; ABCB1 protein affects the susceptibility to Paclitaxel		 CTD PMID:10562306 PMID:10617675 PMID:12708479 PMID:14512701 PMID:15239142 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects uptake ISO ABCB1B protein affects the uptake of Paclitaxel CTD PMID:10562306 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases response to substance ISO ABCB4 protein results in decreased susceptibility to Paclitaxel CTD PMID:17697605 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 decreases expression ISO Paclitaxel results in decreased expression of ABCB6 mRNA CTD PMID:20737486 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance
multiple interactions		 ISO ABCC1 results in decreased susceptibility to Paclitaxel
[Paclitaxel co-treated with IL6 protein] results in increased expression of ABCC1 protein; HIF1A protein affects the reaction [[Paclitaxel co-treated with IL6 protein] results in increased expression of ABCC1 protein]		 CTD PMID:15548710 PMID:29341321 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 multiple interactions
increases expression
decreases response to substance		 ISO ABCC10 protein results in decreased abundance of and results in increased secretion of Paclitaxel; Imatinib Mesylate inhibits the reaction [ABCC10 protein results in decreased abundance of and results in increased secretion of Paclitaxel]; Imatinib Mesylate inhibits the reaction [ABCC10 protein results in decreased susceptibility to Paclitaxel]; nilotinib inhibits the reaction [ABCC10 protein results in decreased abundance of and results in increased secretion of Paclitaxel]; nilotinib inhibits the reaction [ABCC10 protein results in decreased susceptibility to Paclitaxel]
Paclitaxel results in increased expression of ABCC10 mRNA		 CTD PMID:19841739 PMID:20737486 NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases response to substance
increases expression
affects expression
increases export
affects transport
multiple interactions
affects response to substance		 ISO ABCC2 protein results in decreased susceptibility to Paclitaxel
Paclitaxel results in increased expression of ABCC2 mRNA; Paclitaxel results in increased expression of ABCC2 protein
Paclitaxel affects the expression of ABCC2 mRNA
ABCC2 protein results in increased export of Paclitaxel
ABCC2 protein affects the transport of Paclitaxel
montelukast inhibits the reaction [ABCC2 protein results in increased export of Paclitaxel]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Paclitaxel]; Probenecid promotes the reaction [ABCC2 protein results in decreased susceptibility to Paclitaxel]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Paclitaxel]
ABCC2 protein affects the susceptibility to Paclitaxel		 CTD PMID:15645438 PMID:15849751 PMID:19952419 PMID:20737486 PMID:28242239 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Paclitaxel results in increased expression of ABCC3 mRNA; Paclitaxel results in increased expression of ABCC3 protein CTD PMID:20737486 PMID:29625142 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression EXP Paclitaxel results in increased expression of ABCC4 mRNA CTD PMID:15585946 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases expression ISO Paclitaxel results in increased expression of ABCC5 mRNA CTD PMID:20737486 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases expression		 ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of ABCG2 mRNA; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Paclitaxel; [Paclitaxel results in decreased expression of ABCG2] which results in decreased susceptibility to Cisplatin; [Paclitaxel results in decreased expression of ABCG2] which results in decreased susceptibility to Doxorubicin; [Paclitaxel results in decreased expression of ABCG2] which results in decreased susceptibility to Fluorouracil; [Paclitaxel results in decreased expression of ABCG2] which results in decreased susceptibility to Vincristine
Paclitaxel results in decreased expression of ABCG2 mRNA; Paclitaxel results in decreased expression of ABCG2 protein		 CTD PMID:20705681 PMID:21712253 PMID:21833476 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of ABL1 mRNA CTD PMID:29309887 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain decreases expression ISO Paclitaxel results in decreased expression of ACADL protein CTD PMID:15907983 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220 		JBrowse link
G Ackr3 atypical chemokine receptor 3 decreases response to substance ISO ACKR3 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237 		JBrowse link
G Acot8 acyl-CoA thioesterase 8 decreases expression ISO Paclitaxel results in decreased expression of ACOT8 protein CTD PMID:30667213 NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO Paclitaxel results in increased expression of ACTA2 protein CTD PMID:31170432 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of ADAMTS13 mRNA CTD PMID:20705681 NCBI chr 3:10,299,264...10,338,464
Ensembl chr 3:10,300,028...10,346,687 		JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] affects the expression of ADAMTS4 mRNA CTD PMID:20705681 NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065 		JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of ADAMTS5 mRNA CTD PMID:20705681 NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205 		JBrowse link
G Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of ADAMTS7 mRNA CTD PMID:20705681 NCBI chr 8:90,704,727...90,744,333
Ensembl chr 8:90,704,727...90,744,328 		JBrowse link
G Adamtsl4 ADAMTS-like 4 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of ADAMTSL4 mRNA CTD PMID:20705681 NCBI chr 2:183,235,634...183,247,091
Ensembl chr 2:183,235,646...183,246,848 		JBrowse link
G Adcy6 adenylate cyclase 6 decreases expression ISO Paclitaxel results in decreased expression of ADCY6 mRNA CTD PMID:15000894 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754 		JBrowse link
G Add3 adducin 3 affects response to substance ISO ADD3 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124 		JBrowse link
G Adss2 adenylosuccinate synthase 2 decreases expression ISO Paclitaxel results in decreased expression of ADSS2 protein CTD PMID:15907983 NCBI chr13:89,769,240...89,799,577
Ensembl chr13:89,769,244...89,799,604 		JBrowse link
G Agt angiotensinogen multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of AGT mRNA CTD PMID:20705681 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
increases expression		 ISO [Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased expression of AIFM1 protein; [Doxorubicin co-treated with Paclitaxel] results in increased expression of AIFM1 protein; [Tretinoin co-treated with Paclitaxel] affects the localization of AIFM1 protein; [Tretinoin co-treated with Paclitaxel] results in increased expression of AIFM1 protein
Paclitaxel results in increased expression of AIFM1 mRNA		 CTD PMID:16168113 PMID:17701358 PMID:18058816 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases response to substance ISO AKR1B1 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression EXP Paclitaxel analog results in increased expression of AKR1B7 mRNA CTD PMID:15585946 NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases response to substance ISO AKR1C2 mRNA results in increased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects response to substance
increases activity
decreases phosphorylation
decreases response to substance
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of AKT1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Paclitaxel results in increased activity of AKT1 protein]; [Paclitaxel co-treated with Metformin] results in decreased expression of AKT1 mRNA; [PDK1 protein binds to AKT1 protein] results in decreased susceptibility to [Paclitaxel co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]; [PDK1 protein binds to AKT1 protein] which results in decreased susceptibility to Paclitaxel; [pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of AKT1 protein; AKT1 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein]; AKT1 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Paclitaxel results in increased activity of AKT1 protein]
AKT1 protein affects the susceptibility to Paclitaxel
Paclitaxel results in decreased phosphorylation of AKT1 protein
AKT1 protein results in decreased susceptibility to Paclitaxel
Paclitaxel results in increased phosphorylation of AKT1 protein		 CTD PMID:10075725 PMID:16211241 PMID:16782806 PMID:17404021 PMID:18071906 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 affects response to substance
increases phosphorylation
decreases expression
multiple interactions		 ISO
EXP		 AKT2 protein affects the susceptibility to Paclitaxel
Paclitaxel results in increased phosphorylation of AKT2 protein
Paclitaxel results in decreased expression of AKT2 mRNA
Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of AKT2 mRNA]		 CTD PMID:18071906 PMID:36966900 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 affects response to substance ISO AKT3 protein affects the susceptibility to Paclitaxel CTD PMID:18071906 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression
multiple interactions		 ISO Paclitaxel results in decreased expression of ALDH1A1 protein
[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 mRNA]; [Calcitriol co-treated with Paclitaxel] promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; [Curcumin co-treated with Paclitaxel] promotes the reaction [Calcitriol results in decreased expression of ALDH1A1 mRNA]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; Paclitaxel promotes the reaction [Calcitriol results in decreased expression of ALDH1A1 mRNA]; Paclitaxel promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]
Paclitaxel results in decreased expression of ALDH1A1 mRNA; Paclitaxel results in decreased expression of ALDH1A1 protein
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]		 CTD PMID:31628941 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 increases expression ISO Paclitaxel results in increased expression of ALDH9A1 protein CTD PMID:15907983 NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568 		JBrowse link
G Alg8 ALG8, alpha-1,3-glucosyltransferase affects response to substance ISO ALG8 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 1:151,684,344...151,704,310
Ensembl chr 1:151,684,396...151,704,302 		JBrowse link
G Amacr alpha-methylacyl-CoA racemase increases expression EXP Paclitaxel results in increased expression of AMACR mRNA CTD PMID:15585946 NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255 		JBrowse link
G Amfr autocrine motility factor receptor multiple interactions ISO AMFR mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247 		JBrowse link
G Amh anti-Mullerian hormone decreases expression
multiple interactions		 EXP Paclitaxel results in decreased expression of AMH mRNA
parthenolide inhibits the reaction [Paclitaxel results in decreased expression of AMH mRNA]		 CTD PMID:37949423 NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282 		JBrowse link
G Ang angiogenin multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of ANG mRNA CTD PMID:20705681 NCBI chr15:24,312,711...24,323,361 JBrowse link
G Angpt1 angiopoietin 1 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of ANGPT1 mRNA CTD PMID:20705681 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of ANGPTL4 mRNA CTD PMID:20705681 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A affects response to substance ISO ANP32A protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443 		JBrowse link
G Anxa1 annexin A1 increases response to substance ISO ANXA1 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Anxa4 annexin A4 decreases response to substance ISO ANXA4 results in decreased susceptibility to Paclitaxel CTD PMID:21636539 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161 		JBrowse link
G Anxa8 annexin A8 increases response to substance ISO ANXA8 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043 		JBrowse link
G Aox1 aldehyde oxidase 1 affects response to substance ISO AOX1 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression
multiple interactions		 ISO Paclitaxel results in increased expression of APAF1 protein
[Paclitaxel co-treated with Metformin] results in increased expression of APAF1 mRNA
APAF1 protein affects the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]		 CTD PMID:14749477 PMID:17652622 PMID:29309887 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein increases expression EXP Paclitaxel results in increased expression of APBB1IP mRNA CTD PMID:18754875 NCBI chr17:84,941,404...85,033,020
Ensembl chr17:84,982,243...85,033,010 		JBrowse link
G Aplp2 amyloid beta precursor like protein 2 affects response to substance ISO APLP2 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855 		JBrowse link
G Apod apolipoprotein D increases expression ISO Paclitaxel results in increased expression of APOD mRNA CTD PMID:19682730 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305 		JBrowse link
G Ar androgen receptor multiple interactions
decreases localization		 ISO Paclitaxel inhibits the reaction [Dihydrotestosterone results in increased localization of AR protein]
Paclitaxel results in decreased localization of AR protein		 CTD PMID:20807808 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Areg amphiregulin increases expression ISO Paclitaxel results in increased expression of AREG protein CTD PMID:20726858 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arf3 ARF GTPase 3 affects response to substance ISO ARF3 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002 		JBrowse link
G Arhgap24 Rho GTPase activating protein 24 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of ARHGAP24 mRNA CTD PMID:20705681 NCBI chr14:6,800,624...7,183,877
Ensembl chr14:6,800,631...7,183,823 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha multiple interactions
affects response to substance		 ISO ARHGDIA mRNA affects the reaction [Paclitaxel results in increased activity of CASP3 protein]
ARHGDIA mRNA affects the susceptibility to Paclitaxel		 CTD PMID:17264767 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Arr3 arrestin 3 decreases response to substance ISO ARR3 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr  X:65,699,881...65,712,224
Ensembl chr  X:65,698,699...65,712,153 		JBrowse link
G Aspm assembly factor for spindle microtubules increases expression ISO Paclitaxel results in increased expression of ASPM mRNA CTD PMID:17374387 NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression
affects response to substance		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein]]; Minocycline inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein]; Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein]
[ATF3 protein affects the susceptibility to Arsenic] which affects the susceptibility to Paclitaxel; ATF3 protein affects the susceptibility to Paclitaxel		 CTD PMID:16854522 PMID:17005179 PMID:17686523 PMID:18754875 PMID:21050491 More... NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions		 ISO Paclitaxel results in increased expression of ATF4 protein
[norcantharidin co-treated with Paclitaxel] results in increased expression of ATF4 protein; Paclitaxel promotes the reaction [norcantharidin results in increased expression of ATF4 protein]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased expression of ATF4 protein]		 CTD PMID:34272796 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf5 activating transcription factor 5 decreases expression ISO Paclitaxel results in decreased expression of ATF5 mRNA CTD PMID:15000894 NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707 		JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions		 EXP Paclitaxel results in increased expression of ATF6 mRNA
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of ATF6 mRNA]		 CTD PMID:36966900 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP Paclitaxel results in increased expression of ATP2A2 mRNA CTD PMID:15585946 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A affects response to substance ISO ATP6V1A protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694 		JBrowse link
G Atp7a ATPase copper transporting alpha decreases response to substance
increases expression		 ISO ATP7A protein results in decreased susceptibility to Paclitaxel
Paclitaxel results in increased expression of ATP7A mRNA		 CTD PMID:17510416 PMID:20737486 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of ATR mRNA CTD PMID:29309887 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Aurka aurora kinase A increases expression
multiple interactions		 ISO Paclitaxel results in increased expression of AURKA mRNA; Paclitaxel results in increased expression of AURKA protein
[Paclitaxel results in decreased susceptibility to norcantharidin] which results in increased expression of AURKA protein		 CTD PMID:17374387 PMID:34272796 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Aven apoptosis and caspase activation inhibitor multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of AVEN mRNA CTD PMID:29309887 NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634 		JBrowse link
G Axin1 axin 1 multiple interactions ISO [Paclitaxel co-treated with FV-429 compound] promotes the reaction [Oxygen deficiency results in increased expression of AXIN1 protein] CTD PMID:34648812 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Axl Axl receptor tyrosine kinase increases response to substance ISO AXL protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions		 ISO Paclitaxel results in increased expression of BAD mRNA; Paclitaxel results in increased expression of BAD protein
[PD168393 co-treated with Paclitaxel] results in increased expression of BAD protein		 CTD PMID:10822281 PMID:16413505 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bag1 BAG cochaperone 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of BAG1 mRNA CTD PMID:29309887 NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases response to substance
increases expression
multiple interactions
affects expression		 ISO BAK1 protein results in increased susceptibility to Paclitaxel
Paclitaxel results in increased expression of BAK1 mRNA; Paclitaxel results in increased expression of BAK1 protein
[BAK1 protein mutant form co-treated with BAX protein mutant form] inhibits the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]
Paclitaxel affects the expression of BAK1 mRNA; Paclitaxel affects the expression of BAK1 protein		 CTD PMID:10822281 PMID:17652622 PMID:17688235 PMID:24126434 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects response to substance		 ISO
EXP		 [Doxorubicin co-treated with Paclitaxel] results in increased expression of BAX protein; [esculetin co-treated with Paclitaxel] results in increased expression of BAX protein; [fisetin co-treated with Paclitaxel] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX protein; [Paclitaxel co-treated with Gallic Acid] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Gallic Acid] results in increased expression of BAX protein; [Paclitaxel results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein]; [piperine analog co-treated with Paclitaxel] results in increased expression of BAX protein; Cholestanols promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased expression of BAX protein]; Glucosides promotes the reaction [Paclitaxel results in increased expression of BAX protein]; HIF1A protein affects the reaction [IL6 protein inhibits the reaction [Paclitaxel results in increased expression of BAX protein]]; IL6 protein inhibits the reaction [Paclitaxel results in increased expression of BAX protein]; Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]; Paclitaxel promotes the reaction [Cholestanols results in increased expression of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; Paclitaxel promotes the reaction [Glucosides results in increased expression of BAX protein]
[Paclitaxel results in increased expression of TP53 protein] which results in increased expression of BAX mRNA; Paclitaxel results in increased expression of BAX mRNA; Paclitaxel results in increased expression of BAX protein
[BAK1 protein mutant form co-treated with BAX protein mutant form] inhibits the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]; [glabridin co-treated with Paclitaxel] results in increased expression of BAX protein
BAX protein affects the susceptibility to Paclitaxel
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX protein]		 CTD PMID:9041188 PMID:10516758 PMID:10822281 PMID:11726273 PMID:12632493 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases response to substance
increases expression		 ISO BBC3 protein results in increased susceptibility to Paclitaxel
Paclitaxel results in increased expression of BBC3 mRNA; Paclitaxel results in increased expression of BBC3 protein		 CTD PMID:16481741 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 multiple interactions ISO BBS4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 8:59,731,912...59,765,408
Ensembl chr 8:59,731,912...59,765,607 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects response to substance
multiple interactions
decreases expression
increases phosphorylation
increases expression
increases cleavage
decreases degradation
affects localization
decreases activity
increases response to substance
decreases response to substance		 ISO
EXP		 BCL2 protein affects the susceptibility to Paclitaxel
[glabridin co-treated with Paclitaxel] results in decreased expression of BCL2 protein; rottlerin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]
Paclitaxel results in decreased expression of BCL2 mRNA; Paclitaxel results in decreased expression of BCL2 protein
Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of BCL2 protein]
Paclitaxel results in increased phosphorylation of BCL2 protein
Paclitaxel results in increased expression of BCL2 mRNA
Paclitaxel results in increased cleavage of BCL2 protein
Paclitaxel results in decreased degradation of BCL2 protein
Paclitaxel affects the localization of BCL2 protein
Paclitaxel results in decreased activity of BCL2 protein
3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; [CXCL8 results in increased expression of BCL2 mRNA] which results in decreased susceptibility to Paclitaxel; [CXCL8 results in increased expression of BCL2 protein] which results in decreased susceptibility to Paclitaxel; [fisetin co-treated with Paclitaxel] results in increased expression of BCL2 mRNA; [Paclitaxel co-treated with Metformin] results in decreased expression of BCL2 mRNA; [Paclitaxel co-treated with Sorafenib] results in decreased expression of BCL2 protein; [Paclitaxel results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein]; [Paclitaxel results in increased phosphorylation of BCL2 protein] which results in increased susceptibility to Cisplatin; [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of BCL2 protein; [piperine analog co-treated with Paclitaxel] results in decreased expression of BCL2 protein; [Tretinoin co-treated with Paclitaxel] results in decreased expression of BCL2 protein; [Tretinoin co-treated with Paclitaxel] results in increased phosphorylation of BCL2 protein; aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Calcitriol promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Cholestanols promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2 protein]; Curcumin promotes the reaction [Calcitriol promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Cycloheximide inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Cyclosporine promotes the reaction [Paclitaxel results in increased phosphorylation of and results in decreased activity of BCL2 protein]; Dactinomycin inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Doxorubicin promotes the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Genistein inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Glucosides promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; HIF1A protein affects the reaction [IL6 protein inhibits the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; IL6 protein inhibits the reaction [Paclitaxel results in decreased expression of BCL2 protein]; MAP3K1 protein affects the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; MAPK8 protein affects the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Paclitaxel results in decreased expression of and affects the phosphorylation of BCL2 protein; Paclitaxel results in increased phosphorylation of and results in decreased activity of BCL2 protein; Quercetin inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Resveratrol inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Staurosporine inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; TYMP inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]
BCL2 protein mutant form results in increased susceptibility to Paclitaxel
BCL2 mRNA results in decreased susceptibility to Paclitaxel; BCL2 protein results in decreased susceptibility to Paclitaxel		 CTD PMID:7654318 PMID:10502406 PMID:10822281 PMID:10861090 PMID:10881025 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance
increases phosphorylation
increases expression
decreases expression
multiple interactions		 ISO BCL2L1 protein results in decreased susceptibility to Paclitaxel
Paclitaxel results in increased phosphorylation of BCL2L1 protein
Paclitaxel results in increased expression of BCL2L1 mRNA; Paclitaxel results in increased expression of BCL2L1 protein
Paclitaxel results in decreased expression of BCL2L1 mRNA; Paclitaxel results in decreased expression of BCL2L1 protein
[CXCL8 results in increased expression of BCL2L1 mRNA] which results in decreased susceptibility to Paclitaxel; [CXCL8 results in increased expression of BCL2L1 protein] which results in decreased susceptibility to Paclitaxel; [esculetin co-treated with Paclitaxel] results in decreased expression of BCL2L1 protein; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2L1 protein]		 CTD PMID:10822281 PMID:11468182 PMID:11774260 PMID:14749477 PMID:16051289 More... NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 affects response to substance ISO BCL2L11 protein affects the susceptibility to Paclitaxel CTD PMID:17652622 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl6 BCL6, transcription repressor multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of BCL6 mRNA CTD PMID:20705681 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Bcl6b BCL6B, transcription repressor increases expression EXP Paclitaxel results in increased expression of BCL6B mRNA CTD PMID:18754875 NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression		 EXP 1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased expression of BDNF protein] CTD PMID:30414958 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions
affects response to substance		 ISO BECN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]
BECN1 protein affects the susceptibility to Paclitaxel		 CTD PMID:16896004 PMID:31993881 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bgn biglycan affects response to substance ISO BGN protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases cleavage
increases expression		 ISO [Tretinoin co-treated with Paclitaxel] results in increased cleavage of BID protein
Paclitaxel results in increased cleavage of BID protein
Paclitaxel results in increased expression of BID protein		 CTD PMID:14749477 PMID:18098270 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bin1 bridging integrator 1 increases expression ISO Paclitaxel results in increased expression of BIN1 mRNA CTD PMID:19682730 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
G Bin3 bridging integrator 3 decreases expression ISO Paclitaxel results in decreased expression of BIN3 protein CTD PMID:15907983 NCBI chr15:45,173,725...45,212,607
Ensembl chr15:45,173,732...45,212,604 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
affects response to substance
multiple interactions		 ISO Paclitaxel results in decreased expression of BIRC2 protein
BIRC2 protein affects the susceptibility to Paclitaxel
[Tretinoin co-treated with Paclitaxel] results in decreased expression of BIRC2 protein; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC2 protein]		 CTD PMID:14749477 PMID:16217747 PMID:16243823 PMID:17701358 PMID:18098270 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression
multiple interactions		 ISO Paclitaxel results in decreased expression of BIRC3 protein
[Tretinoin co-treated with Paclitaxel] results in decreased expression of BIRC3 protein; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC3 protein]		 CTD PMID:14749477 PMID:16243823 PMID:17701358 PMID:18098270 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases response to substance
multiple interactions
increases expression
decreases expression		 ISO BIRC5 protein results in decreased susceptibility to Paclitaxel; BIRC5 results in decreased susceptibility to Paclitaxel
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Paclitaxel results in increased expression of BIRC5]; [4-(6-cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide co-treated with Paclitaxel] results in decreased expression of BIRC5 protein; [Tretinoin co-treated with Paclitaxel] results in decreased expression of BIRC5 protein; Paclitaxel affects the reaction [BIRC5 protein affects the susceptibility to Melphalan]; Prodigiosin inhibits the reaction [Paclitaxel results in increased expression of BIRC5 protein]; vorinostat inhibits the reaction [Paclitaxel results in increased expression of BIRC5 protein]
Paclitaxel results in increased expression of BIRC5; Paclitaxel results in increased expression of BIRC5 protein
Paclitaxel results in decreased expression of BIRC5 mRNA; Paclitaxel results in decreased expression of BIRC5 promoter; Paclitaxel results in decreased expression of BIRC5 protein		 CTD PMID:12517802 PMID:14749477 PMID:15970709 PMID:16170024 PMID:16202317 More... NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger decreases expression ISO Paclitaxel results in decreased expression of BMI1 mRNA CTD PMID:12929121 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of BMP2 mRNA CTD PMID:20705681 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression ISO Paclitaxel results in decreased expression of BMP4 mRNA CTD PMID:23956100 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Bmp7 bone morphogenetic protein 7 increases response to substance ISO BMP7 mRNA results in increased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO Paclitaxel results in decreased expression of BRCA1 mRNA CTD PMID:15607317 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO Paclitaxel results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:205,731,828...205,743,430
Ensembl chr 1:205,733,872...205,743,421 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression EXP Paclitaxel results in decreased expression of BTG2 mRNA CTD PMID:15585946 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Btg3 BTG anti-proliferation factor 3 multiple interactions
increases expression		 ISO BTG3 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]
Paclitaxel results in increased expression of BTG3 protein		 CTD PMID:15907983 PMID:16896004 NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B multiple interactions
affects response to substance		 ISO [arsenic trioxide co-treated with Paclitaxel] promotes the reaction [BUB1B protein binds to CDC20 protein]; [arsenic trioxide co-treated with Paclitaxel] results in increased expression of BUB1B protein modified form
BUB1B protein affects the susceptibility to Paclitaxel		 CTD PMID:18691855 PMID:19781537 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G Bub3 BUB3 mitotic checkpoint protein increases expression ISO Paclitaxel results in increased expression of BUB3 protein CTD PMID:15907983 NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036 		JBrowse link
G C1qa complement C1q A chain increases expression EXP Paclitaxel results in increased expression of C1QA mRNA CTD PMID:18754875 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain increases expression EXP Paclitaxel results in increased expression of C1QB mRNA CTD PMID:18754875 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C1qc complement C1q C chain increases expression EXP Paclitaxel results in increased expression of C1QC mRNA CTD PMID:18754875 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C1s complement C1s increases expression EXP Paclitaxel results in increased expression of C1S mRNA CTD PMID:18754875 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G C3 complement C3 increases expression EXP Paclitaxel results in increased expression of C3 mRNA CTD PMID:18754875 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C4a complement C4A increases expression EXP Paclitaxel results in increased expression of C4A mRNA CTD PMID:18754875 NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression ISO Paclitaxel results in increased expression of CACNA2D1 mRNA; Paclitaxel results in increased expression of CACNA2D1 protein CTD PMID:16687474 PMID:19336915 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
decreases expression
increases expression		 EXP Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of CALCA protein]; Paclitaxel inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]; Paclitaxel inhibits the reaction [Potassium results in increased secretion of CALCA protein]; pemirolast inhibits the reaction [Paclitaxel results in increased expression of CALCA protein]
Paclitaxel results in decreased expression of CALCA protein		 CTD PMID:15033348 PMID:26883566 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions
increases expression		 EXP 1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased expression of CAMK2A protein] CTD PMID:30414958 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta affects response to substance ISO CAMK2B protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Caprin1 cell cycle associated protein 1 decreases expression ISO Paclitaxel results in decreased expression of CAPRIN1 mRNA CTD PMID:18058816 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502 		JBrowse link
G Car12 carbonic anhydrase 12 multiple interactions ISO CA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression		 ISO [Paclitaxel co-treated with Metformin] results in increased expression of CASP1 mRNA; benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paclitaxel results in increased expression of and results in increased cleavage of CASP1 protein]; benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paclitaxel results in increased expression of CASP1 mRNA]; Paclitaxel results in increased expression of and results in increased cleavage of CASP1 protein CTD PMID:29309887 PMID:31993881 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 decreases expression
multiple interactions
increases expression		 ISO Paclitaxel results in decreased expression of CASP12 protein
[Tretinoin co-treated with Paclitaxel] results in increased expression of CASP12 protein
Paclitaxel results in increased expression of CASP12 protein		 CTD PMID:17701358 PMID:18098270 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp14 caspase 14 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CASP14 mRNA CTD PMID:29309887 NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
increases cleavage		 ISO
EXP		 [4-(6-cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide co-treated with Paclitaxel] results in increased activity of CASP3 protein; [6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine co-treated with Paclitaxel] results in increased activity of CASP3 protein; [Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased activity of CASP3 protein; [Doxorubicin co-treated with Paclitaxel] results in increased activity of CASP3 protein; [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein; [fisetin co-treated with Paclitaxel] results in increased expression of CASP3 mRNA; [Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP3 protein; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of CASP3 protein; [Paclitaxel co-treated with Cisplatin] results in increased activity of CASP3 protein; [Paclitaxel co-treated with Gallic Acid] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Gallic Acid] results in increased expression of CASP3 protein; [PD168393 co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein; [piperine analog co-treated with Paclitaxel] results in increased cleavage of CASP3 protein; [Sirolimus co-treated with Paclitaxel] results in increased cleavage of CASP3 protein; [tipifarnib co-treated with Paclitaxel] results in increased activity of CASP3 protein; [Tretinoin co-treated with Paclitaxel] results in increased activity of CASP3 protein; AKT1 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein]; alvocidib promotes the reaction [Paclitaxel results in increased activity of CASP3 protein]; ARHGDIA mRNA affects the reaction [Paclitaxel results in increased activity of CASP3 protein]; CD40LG protein inhibits the reaction [Paclitaxel promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; Cholestanols promotes the reaction [Paclitaxel results in increased expression of CASP3 protein]; CXCL8 inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]; Glucosides promotes the reaction [Paclitaxel results in increased expression of CASP3 protein]; inostamycin promotes the reaction [Paclitaxel results in increased expression of CASP3 protein modified form]; MAP2K4 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein]; MAP3K5 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein]; MAPK8 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]; Paclitaxel promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; Paclitaxel promotes the reaction [Cholestanols results in increased expression of CASP3 protein]; Paclitaxel promotes the reaction [Glucosides results in increased expression of CASP3 protein]; Paclitaxel promotes the reaction [norcantharidin results in increased expression of CASP3 protein modified form]; Paclitaxel promotes the reaction [NSC 74859 results in decreased expression of CASP3 protein]; Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein; Paclitaxel results in increased cleavage of and results in increased activity of CASP3 protein; Paclitaxel results in increased expression of and results in increased activity of CASP3 protein; palbociclib inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]; TYMP mutant form promotes the reaction [Paclitaxel results in increased cleavage of CASP3 protein]
Paclitaxel results in increased expression of CASP3 mRNA; Paclitaxel results in increased expression of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of CASP3 protein]; Trimetazidine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]
Paclitaxel results in increased expression of CASP3 mRNA; Paclitaxel results in increased expression of CASP3 protein modified form
[BAK1 protein mutant form co-treated with BAX protein mutant form] inhibits the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]; APAF1 protein affects the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]; CASP9 protein affects the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]; Metoclopramide inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]; Paclitaxel inhibits the reaction [Ondansetron results in increased expression of CASP3 protein modified form]; Paclitaxel inhibits the reaction [Tropisetron results in increased expression of CASP3 protein modified form]; Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein
Paclitaxel results in increased expression of CASP3 mRNA; Paclitaxel results in increased expression of CASP3 protein; Paclitaxel results in increased expression of CASP3 protein modified form		 CTD PMID:9818034 PMID:10075725 PMID:10430095 PMID:10516758 PMID:10733772 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases expression
decreases cleavage
multiple interactions		 ISO Paclitaxel results in increased expression of CASP4 mRNA
Paclitaxel results in decreased cleavage of CASP4 protein
[Paclitaxel co-treated with Metformin] results in increased expression of CASP4 mRNA		 CTD PMID:18058816 PMID:29309887 PMID:31993881 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp7 caspase 7 increases activity
increases cleavage
multiple interactions
increases expression		 ISO Paclitaxel results in increased activity of CASP7 protein
Paclitaxel results in increased cleavage of CASP7 protein
[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in increased expression of CASP7 protein]; [Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased activity of CASP7 protein; [Resveratrol co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP7 protein; [Sirolimus co-treated with Paclitaxel] results in increased cleavage of CASP7 protein; Calcitriol inhibits the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; Curcumin inhibits the reaction [Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; palbociclib inhibits the reaction [Paclitaxel results in increased activity of CASP7 protein]
Paclitaxel results in increased expression of CASP7 mRNA; Paclitaxel results in increased expression of CASP7 protein		 CTD PMID:14749477 PMID:15753396 PMID:16168113 PMID:18058816 PMID:22302033 More... NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
increases cleavage
increases activity		 ISO [Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased activity of CASP8 protein; [Doxorubicin co-treated with Paclitaxel] results in increased activity of CASP8 protein; [esculetin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein; [Luteolin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein; [Paclitaxel co-treated with Metformin] results in increased expression of CASP8 mRNA; [Resveratrol co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP8 protein; [Tretinoin co-treated with Paclitaxel] results in increased cleavage of CASP8 protein; [TYMP mutant form co-treated with Paclitaxel] results in increased cleavage of CASP8 protein; Paclitaxel promotes the reaction [norcantharidin results in increased expression of CASP8 protein modified form]; Paclitaxel promotes the reaction [NSC 74859 results in decreased expression of CASP8 protein]
Paclitaxel results in increased expression of CASP8 mRNA
Paclitaxel results in increased expression of CASP8 mRNA; Paclitaxel results in increased expression of CASP8 protein; Paclitaxel results in increased expression of CASP8 protein modified form
Paclitaxel results in increased cleavage of CASP8 protein
Paclitaxel results in increased activity of CASP8 protein		 CTD PMID:11716366 PMID:14749477 PMID:15492279 PMID:15907983 PMID:16051289 More... NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases expression
affects response to substance		 ISO [4-(6-cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide co-treated with Paclitaxel] results in increased activity of CASP9 protein; [6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine co-treated with Paclitaxel] results in increased activity of CASP9 protein; [benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP9 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; [benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP9 protein] which results in decreased susceptibility to Paclitaxel; [Calcitriol co-treated with Paclitaxel] results in increased expression of CASP9 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in increased expression of CASP9 protein]; [Doxorubicin co-treated with Paclitaxel] results in increased activity of CASP9 protein; [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in decreased expression of CASP9 protein modified form; [Paclitaxel co-treated with Calcitriol] promotes the reaction [Curcumin results in increased expression of CASP9 protein]; [Paclitaxel co-treated with Curcumin] promotes the reaction [Calcitriol results in increased expression of CASP9 protein]; [Resveratrol co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP9 protein; [Sirolimus co-treated with Paclitaxel] results in increased cleavage of CASP9 protein; [Tretinoin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP9 protein; Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP9 protein]; Curcumin promotes the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of CASP9 protein]; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased activity of CASP9 protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of CASP9 protein]; Paclitaxel promotes the reaction [Glucosides results in increased expression of CASP9 protein]; Paclitaxel promotes the reaction [norcantharidin results in increased expression of CASP9 protein modified form]; Paclitaxel results in increased cleavage of and results in increased activity of CASP9 protein
[glabridin co-treated with Paclitaxel] results in decreased expression of CASP9 protein; [glabridin co-treated with Paclitaxel] results in increased cleavage of CASP9 protein; CASP9 protein affects the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]
Paclitaxel results in increased activity of CASP9 protein
Paclitaxel results in increased expression of CASP9 mRNA; Paclitaxel results in increased expression of CASP9 protein; Paclitaxel results in increased expression of CASP9 protein modified form
CASP9 protein affects the susceptibility to Paclitaxel		 CTD PMID:14749477 PMID:15753396 PMID:15907983 PMID:16168113 PMID:16170024 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase affects response to substance
decreases expression
multiple interactions
decreases activity
increases response to substance		 ISO
EXP		 CAT protein affects the susceptibility to Paclitaxel
Paclitaxel results in decreased expression of CAT mRNA
Hesperidin inhibits the reaction [Paclitaxel results in decreased activity of CAT protein]; parthenolide inhibits the reaction [Paclitaxel results in decreased activity of CAT protein]; parthenolide inhibits the reaction [Paclitaxel results in decreased expression of CAT mRNA]
CAT results in increased susceptibility to Paclitaxel		 CTD PMID:16217747 PMID:21689642 PMID:36966900 PMID:37949423 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav1 caveolin 1 increases response to substance ISO CAV1 mRNA results in increased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 increases expression ISO Paclitaxel results in increased expression of CCAR1 mRNA CTD PMID:18058816 NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases response to substance ISO CCL2 results in increased susceptibility to Paclitaxel CTD PMID:21187454 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn1 cellular communication network factor 1 increases response to substance ISO CCN1 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] affects the expression of CCN2 mRNA CTD PMID:20705681 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnb1 cyclin B1 increases response to substance
decreases expression
affects expression
multiple interactions
increases expression		 ISO CCNB1 protein results in increased susceptibility to Paclitaxel
Paclitaxel results in decreased expression of CCNB1 protein
Paclitaxel affects the expression of CCNB1 protein
4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline inhibits the reaction [Paclitaxel results in increased expression of CCNB1 protein]; [FV-429 compound co-treated with Oxygen deficiency co-treated with Paclitaxel] affects the expression of CCNB1 protein; [FV-429 compound co-treated with Paclitaxel] results in increased expression of CCNB1 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of CCNB1 mRNA; [pifithrin co-treated with Paclitaxel] results in increased expression of CCNB1 protein; alvocidib inhibits the reaction [Paclitaxel results in increased expression of CCNB1 protein]; CDK7 protein affects the reaction [Paclitaxel results in increased activity of [CDK2 protein binds to CCNB1 protein]]; HIF1A protein affects the reaction [Paclitaxel inhibits the reaction [Oxygen deficiency results in decreased expression of CCNB1 protein]]; Paclitaxel inhibits the reaction [Oxygen deficiency results in decreased expression of CCNB1 protein]; Paclitaxel promotes the reaction [norcantharidin results in decreased expression of CCNB1 protein]; Paclitaxel results in increased activity of [CDK2 protein binds to CCNB1 protein]; Paclitaxel results in increased expression of and results in increased activity of CCNB1 protein		 CTD PMID:10430095 PMID:14646529 PMID:16356831 PMID:16849574 PMID:18516295 More... NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnb2 cyclin B2 affects response to substance
multiple interactions		 ISO CCNB2 protein affects the susceptibility to Paclitaxel
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNB2 mRNA		 CTD PMID:16217747 PMID:29309887 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccnc cyclin C multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCNC mRNA CTD PMID:29309887 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCND1 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CCND1 protein]
Paclitaxel results in decreased expression of CCND1 protein
Paclitaxel results in decreased expression of CCND1 mRNA		 CTD PMID:16243823 PMID:26091902 PMID:29309887 PMID:36683349 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCND2 mRNA CTD PMID:29309887 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in increased expression of CCNE1 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of CCNE1 mRNA CTD PMID:29309887 PMID:34048126 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccne2 cyclin E2 decreases expression ISO Paclitaxel results in decreased expression of CCNE2 mRNA CTD PMID:12929121 PMID:15000894 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Ccnf cyclin F multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCNF mRNA CTD PMID:29309887 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101 		JBrowse link
G Ccng1 cyclin G1 multiple interactions
increases expression 		ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCNG1 mRNA
paclitaxel increases expression of CCNG1 protein in human cancer cell lines		 CTD
RGD		 PMID:29309887 PMID:22056875 RGD:151361152 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Ccng2 cyclin G2 increases expression
multiple interactions		 ISO Paclitaxel results in increased expression of CCNG2 mRNA
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNG2 mRNA		 CTD PMID:12929121 PMID:29309887 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Ccnh cyclin H increases expression ISO Paclitaxel results in increased expression of CCNH protein CTD PMID:15907983 NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819 		JBrowse link
G Cd14 CD14 molecule multiple interactions
increases expression
affects response to substance		 ISO
EXP		 CD14 protein affects the reaction [Paclitaxel results in increased expression of IL12A mRNA]; CD14 protein affects the reaction [Paclitaxel results in increased expression of IL12B mRNA]; CD14 protein affects the reaction [Paclitaxel results in increased expression of PTGS2 mRNA]; CD14 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein]; CD14 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK3 protein]; CD14 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK8 protein]
Paclitaxel results in increased expression of CD14 mRNA
CD14 protein affects the susceptibility to Paclitaxel		 CTD PMID:11123339 PMID:11581577 PMID:18754875 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd163 CD163 molecule increases expression EXP Paclitaxel results in increased expression of CD163 mRNA CTD PMID:18754875 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878 		JBrowse link
G Cd24 CD24 molecule decreases expression ISO Paclitaxel results in decreased expression of CD24 mRNA CTD PMID:19682730 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cd274 CD274 molecule increases expression ISO Paclitaxel results in increased expression of CD274 protein CTD PMID:17920123 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd36 CD36 molecule increases expression EXP Paclitaxel analog results in increased expression of CD36 mRNA CTD PMID:15585946 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd40lg CD40 ligand multiple interactions
decreases response to substance		 ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CD40LG mRNA; CD40LG protein inhibits the reaction [Paclitaxel promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]
CD40LG protein results in decreased susceptibility to Paclitaxel		 CTD PMID:16545138 PMID:29309887 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cd46 CD46 molecule increases response to substance ISO CD46 mRNA results in increased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cd47 Cd47 molecule decreases response to substance ISO CD47 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425 		JBrowse link
G Cd68 Cd68 molecule increases expression EXP Paclitaxel results in increased expression of CD68 protein CTD PMID:16854522 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cda cytidine deaminase affects response to substance ISO CDA protein affects the susceptibility to Paclitaxel CTD PMID:18728667 NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231 		JBrowse link
G Cdc14b cell division cycle 14B decreases expression ISO Paclitaxel results in decreased expression of CDC14B mRNA CTD PMID:18058816 NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235 		JBrowse link
G Cdc16 cell division cycle 16 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDC16 mRNA CTD PMID:29309887 NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550 		JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [Arsenic Trioxide co-treated with Paclitaxel] promotes the reaction [BUB1B protein binds to CDC20 protein]; [Paclitaxel co-treated with Metformin] results in decreased expression of CDC20 mRNA CTD PMID:19781537 PMID:29309887 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Cdc25a cell division cycle 25A increases expression
multiple interactions		 ISO Paclitaxel results in increased expression of CDC25A mRNA
[Paclitaxel co-treated with Metformin] results in decreased expression of CDC25A mRNA		 CTD PMID:12929121 PMID:29309887 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
increases phosphorylation
decreases expression		 ISO [Arsenic Trioxide co-treated with Paclitaxel] results in increased expression of CDC25C protein modified form; [FV-429 compound co-treated with Oxygen deficiency co-treated with Paclitaxel] affects the phosphorylation of CDC25C protein; [FV-429 compound co-treated with Paclitaxel] results in increased phosphorylation of CDC25C protein; [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of CDC25C protein; HIF1A protein affects the reaction [Paclitaxel affects the reaction [Oxygen deficiency results in decreased phosphorylation of CDC25C protein]]; Paclitaxel affects the reaction [Oxygen deficiency results in decreased phosphorylation of CDC25C protein]; Paclitaxel promotes the reaction [norcantharidin results in decreased expression of CDC25C protein]
Paclitaxel results in increased phosphorylation of CDC25C protein
Paclitaxel results in decreased expression of CDC25C mRNA; Paclitaxel results in decreased expression of CDC25C protein		 CTD PMID:18058816 PMID:18516295 PMID:19781537 PMID:34272796 PMID:34648812 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdc27 cell division cycle 27 multiple interactions ISO [arsenic trioxide co-treated with Paclitaxel] results in increased expression of CDC27 protein modified form CTD PMID:19781537 NCBI chr10:89,400,720...89,449,816
Ensembl chr10:89,400,940...89,449,736 		JBrowse link
G Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDC34 mRNA CTD PMID:29309887 NCBI chr 7:10,017,588...10,023,586
Ensembl chr 7:10,017,588...10,023,186 		JBrowse link
G Cdc5l cell division cycle 5-like decreases expression ISO Paclitaxel results in decreased expression of CDC5L mRNA CTD PMID:18058816 NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450 		JBrowse link
G Cdc73 cell division cycle 73 decreases expression ISO Paclitaxel results in decreased expression of CDC73 mRNA CTD PMID:18058816 NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656 		JBrowse link
G Cdca7 cell division cycle associated 7 decreases expression ISO Paclitaxel results in decreased expression of CDCA7 mRNA CTD PMID:18058816 NCBI chr 3:57,322,718...57,333,353
Ensembl chr 3:57,322,708...57,333,353 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [glabridin co-treated with Paclitaxel] results in increased expression of CDH1 protein; Paclitaxel promotes the reaction [rottlerin results in increased expression of CDH1 protein] CTD PMID:35995259 PMID:37419298 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh11 cadherin 11 increases expression ISO Paclitaxel results in increased expression of CDH11 mRNA CTD PMID:19682730 NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in increased expression of CDH2 protein CTD PMID:34048126 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
increases phosphorylation
decreases expression
increases activity		 ISO [Arsenic Trioxide co-treated with Paclitaxel] results in increased activity of CDK1 protein; [Arsenic Trioxide co-treated with Paclitaxel] results in increased expression of CDK1 protein modified form; [FV-429 compound co-treated with Oxygen deficiency co-treated with Paclitaxel] affects the phosphorylation of CDK1 protein; [FV-429 compound co-treated with Paclitaxel] results in increased phosphorylation of CDK1 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of CDK1 mRNA; [pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of CDK1 protein; bryostatin 1 inhibits the reaction [Paclitaxel results in increased activity of CDK1 protein]; HIF1A protein affects the reaction [Paclitaxel promotes the reaction [Oxygen deficiency results in decreased phosphorylation of CDK1 protein]]; Paclitaxel promotes the reaction [Oxygen deficiency results in decreased phosphorylation of CDK1 protein]
Paclitaxel results in increased phosphorylation of CDK1 protein
Paclitaxel results in decreased expression of CDK1 mRNA		 CTD PMID:10516758 PMID:18058816 PMID:18516295 PMID:19781537 PMID:29309887 More... NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk16 cyclin-dependent kinase 16 increases expression EXP Paclitaxel analog results in increased expression of CDK16 mRNA; Paclitaxel results in increased expression of CDK16 mRNA CTD PMID:15585946 NCBI chr  X:1,492,814...1,504,309
Ensembl chr  X:1,492,814...1,504,148 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
increases activity		 ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK2 mRNA; alvocidib inhibits the reaction [Paclitaxel results in increased activity of CDK2 protein]; CDK7 protein affects the reaction [Paclitaxel results in increased activity of [CDK2 protein binds to CCNB1 protein]]; Paclitaxel results in increased activity of [CDK2 protein binds to CCNB1 protein] CTD PMID:10430095 PMID:14646529 PMID:29309887 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk20 cyclin-dependent kinase 20 decreases expression ISO Paclitaxel results in decreased expression of CDK20 mRNA CTD PMID:18058816 NCBI chr17:701,122...707,869
Ensembl chr17:701,124...707,826 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression		 ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK4 mRNA
Paclitaxel results in decreased expression of CDK4 protein		 CTD PMID:29309887 PMID:36683349 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK5R1 mRNA CTD PMID:29309887 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Paclitaxel results in decreased expression of CDK6 protein CTD PMID:36683349 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdk7 cyclin-dependent kinase 7 multiple interactions
increases activity		 ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK7 mRNA; CDK7 protein affects the reaction [Paclitaxel results in increased activity of [CDK2 protein binds to CCNB1 protein]]
Paclitaxel results in increased activity of CDK7 protein		 CTD PMID:14646529 PMID:29309887 NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383 		JBrowse link
G Cdk8 cyclin-dependent kinase 8 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK8 mRNA CTD PMID:29309887 NCBI chr12:8,737,198...8,805,026
Ensembl chr12:8,737,262...8,804,177 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
multiple interactions		 ISO Paclitaxel results in decreased expression of CDKN1A mRNA
Paclitaxel results in increased expression of CDKN1A mRNA; Paclitaxel results in increased expression of CDKN1A protein
[Cisplatin co-treated with Paclitaxel] results in increased expression of CDKN1A mRNA; [Doxorubicin co-treated with Paclitaxel] results in increased expression of CDKN1A protein; [PD168393 co-treated with Paclitaxel] results in increased expression of CDKN1A protein; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]
[Paclitaxel results in increased expression of TP53 protein] which results in increased expression of CDKN1A mRNA; Paclitaxel results in increased expression of CDKN1A protein		 CTD PMID:9041188 PMID:9231689 PMID:12929121 PMID:16168113 PMID:16413505 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CDKN1B mRNA CTD PMID:29309887 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects response to substance ISO CDKN2C protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of CEACAM1 mRNA CTD PMID:20705681 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP Paclitaxel results in increased expression of CEBPD mRNA CTD PMID:18754875 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829 		JBrowse link
G Cenpf centromere protein F multiple interactions
increases expression		 ISO Lovastatin promotes the reaction [Paclitaxel results in increased expression of CENPF protein]; Mevalonic Acid inhibits the reaction [Paclitaxel results in increased expression of CENPF protein] CTD PMID:12467231 NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669 		JBrowse link
G Cenps centromere protein S increases expression ISO Paclitaxel results in increased expression of CENPS mRNA CTD PMID:18058816 NCBI chr 5:159,563,917...159,573,534 JBrowse link
G Cfb complement factor B increases expression EXP Paclitaxel results in increased expression of CFB mRNA CTD PMID:18754875 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfd complement factor D increases expression EXP Paclitaxel results in increased expression of CFD mRNA CTD PMID:18754875 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases response to substance ISO CFLAR protein results in decreased susceptibility to Paclitaxel CTD PMID:16080463 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 decreases expression ISO Paclitaxel results in decreased expression of CHCHD3 mRNA CTD PMID:12929121 NCBI chr 4:61,360,352...61,616,850
Ensembl chr 4:61,360,353...61,616,847 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression
multiple interactions		 ISO Paclitaxel results in decreased expression of CHEK1 mRNA
[Paclitaxel co-treated with Metformin] results in decreased expression of CHEK1 mRNA		 CTD PMID:12929121 PMID:29309887 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK2 mRNA CTD PMID:29309887 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Chfr checkpoint with forkhead and ring finger domains affects response to substance
decreases response to substance		 ISO CHFR protein modified form affects the susceptibility to Paclitaxel
CHFR protein results in decreased susceptibility to Paclitaxel		 CTD PMID:17786301 NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014 		JBrowse link
G Chi3l1 chitinase 3 like 1 increases expression EXP Paclitaxel results in increased expression of CHI3L1 mRNA CTD PMID:18754875 NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787 		JBrowse link
G Cideb cell death-inducing DFFA-like effector b decreases expression ISO Paclitaxel results in decreased expression of CIDEB mRNA CTD PMID:12929121 NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605 		JBrowse link
G Cldn3 claudin 3 decreases response to substance ISO CLDN3 protein results in decreased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001 		JBrowse link
G Clec10a C-type lectin domain containing 10A increases expression EXP Paclitaxel results in increased expression of CLEC10A mRNA CTD PMID:18754875 NCBI chr10:54,876,244...54,880,439
Ensembl chr10:54,876,260...54,880,435 		JBrowse link
G Clec11a C-type lectin domain containing 11A increases expression ISO Paclitaxel results in increased expression of CLEC11A mRNA CTD PMID:19682730 NCBI chr 1:94,800,456...94,809,002
Ensembl chr 1:94,801,496...94,804,633 		JBrowse link
G Clec4a3 C-type lectin domain family 4, member A3 increases expression EXP Paclitaxel results in increased expression of CLEC4A3 mRNA CTD PMID:18754875 NCBI chr 4:156,214,030...156,224,818
Ensembl chr 4:156,214,718...156,224,817 		JBrowse link
G Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit X increases expression ISO Paclitaxel results in increased expression of CLPX protein CTD PMID:15907983 NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082 		JBrowse link
G Clu clusterin decreases response to substance ISO CLU protein results in decreased susceptibility to Paclitaxel CTD PMID:15955107 PMID:16308731 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions
increases expression		 EXP 1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased expression of CNR2 protein]; [1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine binds to and results in increased activity of CNR2 protein] which results in decreased susceptibility to Paclitaxel; [3-(1,1-dimethyl-heptyl)-1-9-dihydroxy-benzo(c)chromen-6-one binds to and results in increased activity of CNR2 protein] which results in decreased susceptibility to Paclitaxel; [AM 1241 binds to and results in increased activity of CNR2 protein] which results in decreased susceptibility to Paclitaxel; iodopravadoline inhibits the reaction [[1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine binds to and results in increased activity of CNR2 protein] which results in decreased susceptibility to Paclitaxel]; SR 144528 inhibits the reaction [[3-(1,1-dimethyl-heptyl)-1-9-dihydroxy-benzo(c)chromen-6-one binds to and results in increased activity of CNR2 protein] which results in decreased susceptibility to Paclitaxel]; SR 144528 inhibits the reaction [[AM 1241 binds to and results in increased activity of CNR2 protein] which results in decreased susceptibility to Paclitaxel] CTD PMID:18664590 PMID:18846037 PMID:30414958 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Coch cochlin increases expression EXP Paclitaxel results in increased expression of COCH mRNA CTD PMID:18754875 NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109 		JBrowse link
G Col11a2 collagen type XI alpha 2 chain multiple interactions ISO [Cisplatin co-treated with Paclitaxel] affects the expression of COL11A2 mRNA CTD PMID:20705681 NCBI chr20:4,786,932...4,816,598
Ensembl chr20:4,786,929...4,815,985 		JBrowse link
G Col15a1 collagen type XV alpha 1 chain decreases response to substance ISO COL15A1 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:25199881 NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591 		JBrowse link
G Col17a1 collagen type XVII alpha 1 chain multiple interactions ISO [Cisplatin co-treated with Paclitaxel] affects the expression of COL17A1 mRNA CTD PMID:20705681 NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain increases expression ISO Paclitaxel results in increased expression of COL18A1 mRNA CTD PMID:19682730 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Paclitaxel results in increased expression of COL1A1 mRNA CTD PMID:19682730 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases response to substance
increases expression		 ISO COL1A2 mRNA results in increased susceptibility to Paclitaxel
Paclitaxel results in increased expression of COL1A2 mRNA		 CTD PMID:19682730 PMID:25199881 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col20a1 collagen type XX alpha 1 chain multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of COL20A1 mRNA CTD PMID:20705681 NCBI chr 3:168,102,475...168,134,759
Ensembl chr 3:168,084,560...168,135,309 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
decreases response to substance		 ISO [Cisplatin co-treated with Paclitaxel] affects the expression of COL3A1 mRNA
COL3A1 mRNA results in decreased susceptibility to Paclitaxel		 CTD PMID:20705681 PMID:25199881 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain increases expression ISO Paclitaxel results in increased expression of COL4A1 mRNA CTD PMID:19682730 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Col4a2 collagen type IV alpha 2 chain multiple interactions
increases expression		 ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of COL4A2 mRNA
Paclitaxel results in increased expression of COL4A2 mRNA		 CTD PMID:19682730 PMID:20705681 NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839 		JBrowse link
G Col5a2 collagen type V alpha 2 chain decreases response to substance ISO COL5A2 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:25199881 NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain increases expression ISO Paclitaxel results in increased expression of COL6A1 mRNA CTD PMID:19682730 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Col6a2 collagen type VI alpha 2 chain increases expression ISO Paclitaxel results in increased expression of COL6A2 mRNA CTD PMID:19682730 NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564 		JBrowse link
G Col6a3 collagen type VI alpha 3 chain affects response to substance ISO COL6A3 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471 		JBrowse link
G Col7a1 collagen type VII alpha 1 chain increases response to substance ISO COL7A1 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252 		JBrowse link
G Cope COPI coat complex subunit epsilon affects response to substance ISO COPE protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr16:19,114,871...19,125,076
Ensembl chr16:19,114,871...19,128,907 		JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 decreases expression ISO Paclitaxel results in decreased expression of COX15 mRNA CTD PMID:15000894 NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261 		JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 affects response to substance ISO COX17 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cp ceruloplasmin increases expression EXP Paclitaxel results in increased expression of CP mRNA CTD PMID:18754875 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
multiple interactions		 ISO Paclitaxel results in decreased expression of CPT1A protein
[Paclitaxel co-treated with FV-429 compound co-treated with Oxygen deficiency] results in increased expression of CPT1A mRNA		 CTD PMID:30667213 PMID:34648812 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Paclitaxel results in decreased expression of CPT2 protein CTD PMID:30667213 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions		 EXP Paclitaxel results in increased phosphorylation of CREB1 protein
1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased phosphorylation of CREB1 protein]		 CTD PMID:30414958 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 affects response to substance ISO CREG1 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308 		JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO [CSF3 protein co-treated with Paclitaxel] results in decreased abundance of Choline; [CSF3 protein co-treated with Paclitaxel] results in decreased abundance of Creatine; [CSF3 protein co-treated with Paclitaxel] results in decreased abundance of Inositol CTD PMID:9018096 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Ctbp1 C-terminal binding protein 1 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of CTBP1 mRNA CTD PMID:20705681 NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821 		JBrowse link
G Ctcf CCCTC-binding factor decreases response to substance ISO CTCF mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr19:33,521,726...33,571,124
Ensembl chr19:33,529,319...33,571,123 		JBrowse link
G Ctnnb1 catenin beta 1 decreases response to substance
multiple interactions
decreases phosphorylation		 ISO CTNNB1 results in decreased susceptibility to Paclitaxel
[Oxygen deficiency co-treated with Paclitaxel co-treated with FV-429 compound co-treated with Deferoxamine] affects the localization of CTNNB1 protein; [Paclitaxel co-treated with FV-429 compound] inhibits the reaction [Oxygen deficiency results in increased expression of CTNNB1 protein]
Paclitaxel results in decreased phosphorylation of CTNNB1 protein		 CTD PMID:22000491 PMID:23956100 PMID:34648812 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctnnd2 catenin delta 2 multiple interactions ISO CTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 2:81,168,525...82,016,495
Ensembl chr 2:81,167,117...82,015,764 		JBrowse link
G Ctse cathepsin E increases expression EXP Paclitaxel analog results in increased expression of CTSE mRNA; Paclitaxel results in increased expression of CTSE mRNA CTD PMID:15585946 NCBI chr13:43,091,954...43,114,509
Ensembl chr13:43,092,128...43,114,502 		JBrowse link
G Ctsk cathepsin K increases expression EXP Paclitaxel analog results in increased expression of CTSK mRNA; Paclitaxel results in increased expression of CTSK mRNA CTD PMID:15585946 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Ctsl cathepsin L increases response to substance
decreases response to substance		 ISO CTSL mRNA results in increased susceptibility to Paclitaxel
CTSL protein results in decreased susceptibility to Paclitaxel		 CTD PMID:16322897 PMID:31370861 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Ctss cathepsin S increases expression EXP Paclitaxel results in increased expression of CTSS mRNA CTD PMID:18754875 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cttn cortactin decreases expression ISO Paclitaxel results in decreased expression of CTTN protein CTD PMID:15907983 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Paclitaxel results in increased expression of CXCL1 mRNA CTD PMID:18754875 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions		 ISO Paclitaxel results in increased expression of CXCL10 mRNA
TLR4 protein affects the reaction [Paclitaxel results in increased expression of CXCL10 mRNA]		 CTD PMID:11123339 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression EXP Paclitaxel results in increased expression of CXCL14 mRNA CTD PMID:18754875 NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
decreases response to substance		 ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of CXCR4 mRNA
CXCR4 mRNA results in decreased susceptibility to Paclitaxel		 CTD PMID:16322897 PMID:20705681 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cxcr6 C-X-C motif chemokine receptor 6 decreases response to substance ISO CXCR6 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr 8:123,434,417...123,439,568
Ensembl chr 8:123,416,325...123,439,526 		JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
increases secretion
increases expression		 ISO Paclitaxel affects the localization of CYCS protein
[esculetin co-treated with Paclitaxel] affects the localization of CYCS protein; [PD168393 co-treated with Paclitaxel] affects the localization of CYCS protein; [resveratrol co-treated with Paclitaxel] affects the localization of CYCS protein; [tipifarnib co-treated with Paclitaxel] affects the localization of CYCS protein
Paclitaxel results in increased secretion of CYCS protein
Paclitaxel results in increased expression of CYCS protein		 CTD PMID:10516758 PMID:14749477 PMID:15728126 PMID:15907983 PMID:16051289 More... NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO Paclitaxel results in increased activity of CYP19A1 protein CTD PMID:14691014 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Paclitaxel inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:11602686 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity		 EXP
ISO		 Paclitaxel results in increased expression of CYP1A2 mRNA
Paclitaxel results in decreased activity of CYP1A2 protein		 CTD PMID:15585946 PMID:19909766 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CYP27B1 mRNA CTD PMID:29309887 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 increases expression EXP Paclitaxel analog results in increased expression of CYP2C12 mRNA CTD PMID:15585946 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [glabridin co-treated with Paclitaxel] results in decreased expression of CYP2C8 protein CTD PMID:37419298 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases response to substance
affects response to substance
multiple interactions
increases oxidation
increases metabolic processing
increases hydroxylation
affects metabolic processing		 ISO CYP2C8 mRNA results in increased susceptibility to Paclitaxel
CYP2C8 gene SNP affects the susceptibility to Paclitaxel
Cyclohexenes analog inhibits the reaction [CYP2C8 protein results in increased metabolism of Paclitaxel]; perfluorooctane sulfonic acid inhibits the reaction [CYP2C8 protein results in increased hydroxylation of Paclitaxel]; sitaxsentan inhibits the reaction [CYP2C8 protein results in increased metabolism of Paclitaxel]
CYP2C8 protein results in increased oxidation of Paclitaxel
CYP2C8 protein affects the metabolism of Paclitaxel		 CTD PMID:12401345 PMID:12464242 PMID:15239142 PMID:15716363 PMID:15901749 More...
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Paclitaxel results in decreased activity of CYP2D6 protein CTD PMID:19909766 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions		 EXP Paclitaxel results in decreased activity of CYP2E1 protein
turmeric extract affects the reaction [Paclitaxel results in decreased activity of CYP2E1 protein]		 CTD PMID:24882083 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO [glabridin co-treated with Paclitaxel] results in decreased expression of CYP2J2 protein; [rottlerin co-treated with Paclitaxel] results in decreased expression of CYP2J2 protein CTD PMID:35995259 PMID:37419298 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases oxidation
decreases activity
increases activity
increases hydroxylation
affects metabolic processing
multiple interactions		 EXP
ISO		 Paclitaxel results in increased expression of CYP3A4 protein
CYP3A4 protein results in increased oxidation of Paclitaxel
Paclitaxel results in decreased activity of CYP3A4 protein
Paclitaxel results in increased activity of CYP3A4 protein
Paclitaxel results in increased expression of CYP3A4 mRNA; Paclitaxel results in increased expression of CYP3A4 protein
CYP3A4 protein results in increased hydroxylation of Paclitaxel
CYP3A4 protein affects the metabolism of Paclitaxel
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Paclitaxel]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein]; Oxygen deficiency inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Paclitaxel]
Plant Extracts inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein]		 CTD PMID:12065438 PMID:12237780 PMID:15650019 PMID:15901749 PMID:15918522 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP Paclitaxel results in increased expression of CYP4A22 mRNA CTD PMID:15585946 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP Paclitaxel results in decreased expression of CYP7A1 mRNA CTD PMID:15585946 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Dapk1 death associated protein kinase 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of DAPK1 mRNA CTD PMID:29309887 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991 		JBrowse link
G Dazl deleted in azoospermia-like multiple interactions
decreases expression		 EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of DAZL mRNA] CTD PMID:37949423 NCBI chr 9:10,695,593...10,712,330
Ensembl chr 9:10,695,592...10,712,323 		JBrowse link
G Dbf4 DBF4-CDC7 kinase regulatory subunit decreases expression ISO Paclitaxel results in decreased expression of DBF4 mRNA CTD PMID:12929121 NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066 		JBrowse link
G Dcn decorin decreases response to substance ISO DCN mRNA results in decreased susceptibility to Paclitaxel CTD PMID:25199881 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Dctd dCMP deaminase affects response to substance ISO DCTD protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr16:44,066,952...44,098,654
Ensembl chr16:44,055,128...44,098,446 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO [norcantharidin co-treated with Paclitaxel] results in increased expression of DDIT3 protein; Paclitaxel promotes the reaction [norcantharidin results in increased expression of DDIT3 protein]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased expression of DDIT3 protein]
Paclitaxel results in increased expression of DDIT3 mRNA
Ursolic Acid inhibits the reaction [Paclitaxel results in increased expression of DDIT3 mRNA]
Paclitaxel results in increased expression of DDIT3 protein		 CTD PMID:34272796 PMID:38437959 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddx23 DEAD-box helicase 23 affects response to substance ISO DDX23 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 7:129,797,620...129,814,909
Ensembl chr 7:129,797,614...129,814,949 		JBrowse link
G Ddx4 DEAD-box helicase 4 decreases expression EXP Paclitaxel results in decreased expression of DDX4 mRNA CTD PMID:37949423 NCBI chr 2:44,227,946...44,282,867
Ensembl chr 2:44,227,946...44,282,723 		JBrowse link
G Dedd death effector domain-containing decreases expression ISO Paclitaxel results in decreased expression of DEDD mRNA CTD PMID:15000894 NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha decreases expression
multiple interactions
increases cleavage		 ISO Paclitaxel results in decreased expression of DFFA protein
[Paclitaxel co-treated with Metformin] results in decreased expression of DFFA mRNA; [Tretinoin co-treated with Paclitaxel] results in increased cleavage of DFFA protein
Paclitaxel results in increased cleavage of DFFA protein		 CTD PMID:15907983 PMID:17701358 PMID:18098270 PMID:29309887 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects response to substance ISO DHCR24 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of DHCR7 mRNA CTD PMID:20705681 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization
increases expression
multiple interactions		 ISO Paclitaxel affects the localization of DIABLO protein
Paclitaxel results in increased expression of DIABLO protein
[resveratrol co-treated with Paclitaxel] affects the localization of DIABLO protein; [Tretinoin co-treated with Paclitaxel] affects the localization of DIABLO protein; [Tretinoin co-treated with Paclitaxel] results in increased expression of DIABLO protein		 CTD PMID:14749477 PMID:17701358 PMID:18098270 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Dmtf1 cyclin D binding myb-like transcription factor 1 decreases expression ISO Paclitaxel results in decreased expression of DMTF1 mRNA CTD PMID:15000894 NCBI chr 4:24,909,937...24,950,786
Ensembl chr 4:24,910,534...24,950,967 		JBrowse link
G Dnase1l3 deoxyribonuclease 1L3 decreases expression EXP Paclitaxel results in decreased expression of DNASE1L3 mRNA CTD PMID:15585946 NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase affects expression
decreases expression
multiple interactions		 ISO Paclitaxel affects the expression of DPYD mRNA
Paclitaxel results in decreased expression of DPYD mRNA
[Paclitaxel co-treated with doxifluridine] affects the expression of DPYD mRNA		 CTD PMID:16568373 PMID:18630517 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Dsp desmoplakin affects response to substance ISO DSP protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800 		JBrowse link
G Dst dystonin multiple interactions ISO [Cisplatin co-treated with Paclitaxel] affects the expression of DST mRNA CTD PMID:20705681 NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615 		JBrowse link
G Dusp3 dual specificity phosphatase 3 decreases expression ISO Paclitaxel results in decreased expression of DUSP3 mRNA CTD PMID:15000894 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 multiple interactions ISO [Paclitaxel co-treated with FV-429 compound co-treated with Oxygen deficiency] results in decreased expression of DVL2 protein CTD PMID:34648812 NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820 		JBrowse link
G E2f1 E2F transcription factor 1 increases response to substance
increases expression
multiple interactions		 ISO
EXP		 E2F1 protein results in increased susceptibility to Paclitaxel
Paclitaxel results in increased expression of E2F1 mRNA
royal jelly inhibits the reaction [Paclitaxel results in increased expression of E2F1 mRNA]		 CTD PMID:16849574 PMID:27496854 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO E2F3 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253 		JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of E2F4 mRNA CTD PMID:29309887 NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806 		JBrowse link
G E2f5 E2F transcription factor 5 increases expression ISO Paclitaxel results in increased expression of E2F5 mRNA CTD PMID:15000894 NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Paclitaxel results in increased expression of ECH1 mRNA CTD PMID:15585946 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Ecm1 extracellular matrix protein 1 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] affects the expression of ECM1 mRNA CTD PMID:20705681 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression ISO Paclitaxel results in decreased expression of EEF2 mRNA CTD PMID:15000894 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Efcab7 EF-hand calcium binding domain 7 affects response to substance ISO EFCAB7 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 5:114,525,403...114,576,130
Ensembl chr 5:114,525,167...114,576,129 		JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of EFEMP1 mRNA CTD PMID:20705681 NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018 		JBrowse link
G Efna1 ephrin A1 decreases expression ISO Paclitaxel results in decreased expression of EFNA1 mRNA CTD PMID:19682730 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Egf epidermal growth factor multiple interactions
decreases expression		 ISO Paclitaxel inhibits the reaction [EGF protein results in increased expression of PSA mRNA]
Paclitaxel results in decreased expression of EGF mRNA		 CTD PMID:18058816 PMID:20807808 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfl6 EGF-like-domain, multiple 6 decreases response to substance ISO EGFL6 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:25199881 NCBI chr  X:27,884,087...27,942,044
Ensembl chr  X:27,884,125...27,942,044 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
decreases expression		 ISO [PD168393 co-treated with Paclitaxel] results in decreased phosphorylation of EGFR protein; Paclitaxel promotes the reaction [HER3 protein binds to EGFR protein]
Paclitaxel results in increased phosphorylation of EGFR protein
Paclitaxel results in decreased expression of EGFR mRNA		 CTD PMID:16211241 PMID:16413505 PMID:18058816 PMID:20726858 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ehf ets homologous factor decreases expression ISO Paclitaxel results in decreased expression of EHF mRNA CTD PMID:19682730 NCBI chr 3:89,639,845...89,680,061
Ensembl chr 3:89,641,833...89,679,997 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 affects response to substance
increases expression
multiple interactions		 ISO
EXP		 EIF2AK3 protein affects the susceptibility to Paclitaxel
Paclitaxel results in increased expression of EIF2AK3 mRNA
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of EIF2AK3 mRNA]		 CTD PMID:16217747 PMID:36966900 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha affects phosphorylation
increases phosphorylation
multiple interactions		 ISO Paclitaxel affects the phosphorylation of EIF2S1 protein
Paclitaxel results in increased phosphorylation of EIF2S1 protein
[norcantharidin co-treated with Paclitaxel] results in increased phosphorylation of EIF2S1 protein; Paclitaxel promotes the reaction [norcantharidin results in increased phosphorylation of EIF2S1 protein]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased phosphorylation of EIF2S1 protein]		 CTD PMID:29053414 PMID:34272796 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 decreases expression ISO Paclitaxel results in decreased expression of EIF4A1 protein CTD PMID:15907983 NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858 		JBrowse link
G Eif5a eukaryotic translation initiation factor 5A increases response to substance ISO EIF5A protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656 		JBrowse link
G Elk1 ETS transcription factor ELK1 decreases expression ISO Paclitaxel results in decreased expression of ELK1 mRNA CTD PMID:12929121 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Elmo3 engulfment and cell motility 3 increases expression ISO Paclitaxel results in increased expression of ELMO3 protein CTD PMID:15907983 NCBI chr19:33,181,952...33,186,399
Ensembl chr19:33,182,036...33,186,410 		JBrowse link
G Emp1 epithelial membrane protein 1 increases expression EXP Paclitaxel results in increased expression of EMP1 mRNA CTD PMID:18754875 NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904 		JBrowse link
G Emp3 epithelial membrane protein 3 increases expression ISO Paclitaxel results in increased expression of EMP3 mRNA CTD PMID:19682730 NCBI chr 1:96,388,651...96,391,946
Ensembl chr 1:96,388,652...96,391,988 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression ISO Paclitaxel results in increased expression of ENPP2 mRNA CTD PMID:19682730 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions
decreases expression
increases expression		 ISO [Paclitaxel co-treated with Carboplatin] results in increased expression of EPCAM protein
Paclitaxel results in decreased expression of EPCAM mRNA; Paclitaxel results in decreased expression of EPCAM protein
Paclitaxel results in increased expression of EPCAM protein		 CTD PMID:12695858 PMID:15907983 PMID:19682730 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Ephx2 epoxide hydrolase 2 increases expression EXP Paclitaxel results in increased expression of EPHX2 mRNA CTD PMID:18754875 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Epo erythropoietin decreases response to substance ISO EPO protein results in decreased susceptibility to Paclitaxel CTD PMID:17010629 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases response to substance
affects response to substance		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Paclitaxel]; 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Paclitaxel]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Paclitaxel; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Paclitaxel]; Paclitaxel results in decreased phosphorylation of and results in decreased activity of ERBB2 protein
ERBB2 protein results in decreased susceptibility to Paclitaxel; ERBB2 results in decreased susceptibility to Paclitaxel
ERBB2 protein affects the susceptibility to Paclitaxel		 CTD PMID:10327070 PMID:16580691 PMID:21712253 PMID:25866362 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases response to substance ISO ERBB3 protein results in decreased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO ERBB4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease increases expression ISO Paclitaxel results in increased expression of ERCC5 mRNA CTD PMID:12929121 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression		 ISO
EXP		 Paclitaxel promotes the reaction [norcantharidin results in increased expression of ERN1 protein]
Paclitaxel results in increased expression of ERN1 mRNA
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of ERN1 mRNA]
Paclitaxel results in increased expression of ERN1 protein		 CTD PMID:34272796 PMID:36966900 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases expression		 ISO alitretinoin inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA]; beta Carotene inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA]; Paclitaxel inhibits the reaction [Tamoxifen binds to ESR1 protein]; Vitamin A inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] CTD PMID:15283693 PMID:19340624 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases expression
decreases expression
multiple interactions		 ISO Paclitaxel results in increased expression of ESR2 mRNA
Paclitaxel results in decreased expression of ESR2 mRNA
alitretinoin inhibits the reaction [Paclitaxel results in increased expression of ESR2 mRNA]		 CTD PMID:19340624 PMID:23956100 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G F13a1 coagulation factor XIII A1 chain increases expression EXP Paclitaxel results in increased expression of F13A1 mRNA CTD PMID:18754875 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions ISO [Paclitaxel co-treated with F2 protein] affects the localization of RELA protein; [Paclitaxel co-treated with F2 protein] results in increased activity of F3 protein; [Paclitaxel co-treated with F2 protein] results in increased expression of F3 mRNA; [Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein; [Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK8 protein; [Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK9 protein; epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased activity of F3 protein]; epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 mRNA]; epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]; epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK8 protein]; epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein] CTD PMID:19944065 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO [Paclitaxel co-treated with F2 protein] results in increased activity of F3 protein; [Paclitaxel co-treated with F2 protein] results in increased expression of F3 mRNA; [Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein; epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased activity of F3 protein]; epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 mRNA]; epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein]; pyrazolanthrone inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased expression of F3 protein] CTD PMID:19944065 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Paclitaxel results in decreased expression of FABP1 protein CTD PMID:30667213 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fabp3 fatty acid binding protein 3 multiple interactions ISO [FV-429 compound co-treated with Paclitaxel] inhibits the reaction [Oxygen deficiency results in increased expression of FABP3 protein] CTD PMID:34648812 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Fabp7 fatty acid binding protein 7 multiple interactions ISO [FV-429 compound co-treated with Paclitaxel] inhibits the reaction [Oxygen deficiency results in increased expression of FABP7 protein]; Paclitaxel inhibits the reaction [Oxygen deficiency results in increased expression of FABP7 protein] CTD PMID:34648812 NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880 		JBrowse link
G Fadd Fas associated via death domain multiple interactions
increases phosphorylation
increases expression		 ISO pyrazolanthrone inhibits the reaction [Paclitaxel results in increased phosphorylation of FADD protein]
Paclitaxel results in increased expression of FADD mRNA		 CTD PMID:16450001 PMID:18058816 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fam234b family with sequence similarity 234, member B multiple interactions ISO FAM234B mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 4:168,048,313...168,124,017
Ensembl chr 4:168,048,396...168,097,338 		JBrowse link
G Fam3c FAM3 metabolism regulating signaling molecule C affects response to substance ISO FAM3C protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 4:50,839,929...50,887,276
Ensembl chr 4:50,838,818...50,888,078 		JBrowse link
G Fancl FA complementation group L affects response to substance ISO FANCL protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
decreases expression
increases response to substance		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of FAS protein; cacalol promotes the reaction [Paclitaxel results in decreased expression of FAS mRNA]; Paclitaxel promotes the reaction [cacalol results in decreased expression of FAS mRNA]
Paclitaxel results in increased expression of FAS mRNA
Paclitaxel results in increased expression of FAS protein
FAS protein results in increased susceptibility to Paclitaxel		 CTD PMID:16051289 PMID:17449502 PMID:18074150 PMID:20665104 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
increases response to substance		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of FASLG protein; TYMP inhibits the reaction [Paclitaxel results in increased expression of FASLG mRNA]; TYMP inhibits the reaction [Paclitaxel results in increased expression of FASLG protein]
Paclitaxel results in increased expression of FASLG mRNA; Paclitaxel results in increased expression of FASLG protein
FASLG protein results in increased susceptibility to Paclitaxel		 CTD PMID:10502406 PMID:11716366 PMID:15907805 PMID:16051289 PMID:18074150 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions		 ISO Paclitaxel results in decreased expression of FASN protein
[FV-429 compound co-treated with Paclitaxel] inhibits the reaction [Oxygen deficiency results in increased expression of FASN protein]; [Paclitaxel co-treated with FV-429 compound co-treated with Deferoxamine] promotes the reaction [Oxygen deficiency results in increased expression of FASN protein]; [Paclitaxel co-treated with FV-429 compound] inhibits the reaction [Oxygen deficiency results in increased expression of FASN mRNA]; [Paclitaxel co-treated with FV-429 compound] inhibits the reaction [Oxygen deficiency results in increased expression of FASN protein]; Paclitaxel inhibits the reaction [Oxygen deficiency results in increased expression of FASN protein]		 CTD PMID:30667213 PMID:34648812 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbn1 fibrillin 1 increases expression ISO Paclitaxel results in increased expression of FBN1 mRNA CTD PMID:19682730 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Fbxo5 F-box protein 5 affects expression ISO Paclitaxel affects the expression of FBXO5 protein CTD PMID:27769712 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437 		JBrowse link
G Fcgr2a Fc gamma receptor 2A increases expression EXP Paclitaxel results in increased expression of FCGR3 mRNA CTD PMID:18754875 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967 		JBrowse link
G Fcgr2b Fc gamma receptor 2B increases expression EXP Paclitaxel results in increased expression of FCGR2B mRNA CTD PMID:18754875 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects response to substance ISO FDFT1 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Fdps farnesyl diphosphate synthase increases response to substance ISO FDPS mRNA results in increased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Fgb fibrinogen beta chain decreases expression EXP Paclitaxel results in decreased expression of FGB mRNA CTD PMID:15585946 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases response to substance ISO FGF2 protein results in decreased susceptibility to Paclitaxel CTD PMID:16741658 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgf5 fibroblast growth factor 5 affects response to substance ISO FGF5 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997 		JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of FGF7 mRNA CTD PMID:20705681 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Fgfbp1 fibroblast growth factor binding protein 1 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of FGFBP1 mRNA CTD PMID:20705681 NCBI chr14:67,103,686...67,107,492
Ensembl chr14:67,104,545...67,107,496 		JBrowse link
G Fgfrl1 fibroblast growth factor receptor-like 1 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of FGFRL1 mRNA CTD PMID:20705681 NCBI chr14:1,009,863...1,022,620
Ensembl chr14:1,009,786...1,021,928 		JBrowse link
G Fhl1 four and a half LIM domains 1 increases response to substance ISO FHL1 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928 		JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP Paclitaxel results in increased expression of FIS1 protein CTD PMID:26732598 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of FKBP1A mRNA CTD PMID:29309887 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Fkbp3 FKBP prolyl isomerase 3 increases expression ISO Paclitaxel results in increased expression of FKBP3 mRNA CTD PMID:12929121 NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression ISO Paclitaxel results in increased expression of FLT1 CTD PMID:21975929 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of FN1 mRNA; [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in increased expression of FN1 protein CTD PMID:20705681 PMID:34048126 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP Paclitaxel results in increased expression of FOSB protein alternative form
1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased expression of FOSB protein alternative form]		 CTD PMID:30414958 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Fras1 Fraser extracellular matrix complex subunit 1 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of FRAS1 mRNA CTD PMID:20705681 NCBI chr14:12,791,407...13,200,862
Ensembl chr14:12,793,599...13,200,726 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 increases response to substance ISO FSCN1 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G Fshr follicle stimulating hormone receptor decreases expression ISO Paclitaxel results in decreased expression of FSHR mRNA CTD PMID:23956100 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Fth1 ferritin heavy chain 1 decreases response to substance ISO FTH1 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 decreases response to substance ISO FTL mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases response to substance ISO FURIN mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 increases response to substance
decreases expression		 ISO FXYD3 mRNA results in increased susceptibility to Paclitaxel
Paclitaxel results in decreased expression of FXYD3 mRNA		 CTD PMID:16322897 PMID:19682730 NCBI chr 1:86,305,531...86,312,455 JBrowse link
G G0s2 G0/G1switch 2 increases expression EXP Paclitaxel analog results in increased expression of G0S2 mRNA; Paclitaxel results in increased expression of G0S2 mRNA CTD PMID:15585946 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases expression EXP Paclitaxel results in increased expression of G6PC1 mRNA CTD PMID:15585946 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
decreases response to substance		 ISO [Paclitaxel results in increased expression of TP53 protein] which results in increased expression of GADD45A mRNA
GADD45A mRNA results in decreased susceptibility to Paclitaxel		 CTD PMID:9041188 PMID:16322897 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Galnt7 polypeptide N-acetylgalactosaminyltransferase 7 affects response to substance ISO GALNT7 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr16:32,578,643...32,703,189
Ensembl chr16:32,578,690...32,702,690 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase multiple interactions ISO GAMT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778 		JBrowse link
G Gchfr GTP cyclohydrolase I feedback regulator decreases response to substance ISO GCHFR protein results in decreased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080 		JBrowse link
G Gckr glucokinase regulator increases expression EXP Paclitaxel results in increased expression of GCKR mRNA CTD PMID:15585946 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654 		JBrowse link
G Gdf9 growth differentiation factor 9 increases expression ISO Paclitaxel results in increased expression of GDF9 mRNA CTD PMID:35584731 NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression		 ISO
EXP		 [Tretinoin co-treated with Paclitaxel] results in increased expression of GFAP protein
Paclitaxel results in increased expression of GFAP protein		 CTD PMID:16854522 PMID:17005179 PMID:18098270 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 decreases response to substance ISO GFPT1 protein results in decreased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions ISO GFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473 		JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP Paclitaxel results in increased expression of GJB2 mRNA CTD PMID:18754875 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177 		JBrowse link
G Gjb6 gap junction protein, beta 6 increases expression EXP Paclitaxel results in increased expression of GJB6 mRNA CTD PMID:18754875 NCBI chr15:31,284,561...31,294,552
Ensembl chr15:31,284,419...31,294,582 		JBrowse link
G Gna13 G protein subunit alpha 13 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of GNA13 mRNA CTD PMID:20705681 NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774 		JBrowse link
G Gpc3 glypican 3 increases response to substance ISO GPC3 mRNA results in increased susceptibility to Paclitaxel CTD PMID:25199881 NCBI chr  X:131,868,986...132,236,824
Ensembl chr  X:131,868,990...132,236,798 		JBrowse link
G Gpi glucose-6-phosphate isomerase affects response to substance ISO GPI protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086 		JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Paclitaxel results in increased expression of GPNMB mRNA CTD PMID:18754875 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367 		JBrowse link
G Gpr35 G protein-coupled receptor 35 decreases response to substance ISO GPR35 protein results in decreased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions
decreases expression		 EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of GPX2 mRNA] CTD PMID:37949423 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions
increases expression		 EXP 1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased expression of GRIA1 protein] CTD PMID:30414958 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases expression		 EXP 1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased expression of GRIN2B protein] CTD PMID:30414958 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grn granulin precursor multiple interactions
decreases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of GRN mRNA]]; Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of GRN mRNA] CTD PMID:35662665 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Gsdmd gasdermin D multiple interactions
affects response to substance		 ISO benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paclitaxel results in increased expression of and results in increased cleavage of GSDMD protein]; Paclitaxel results in increased expression of and results in increased cleavage of GSDMD protein
GSDMD protein affects the susceptibility to Paclitaxel		 CTD PMID:31993881 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions		 ISO Paclitaxel results in increased phosphorylation of GSK3B protein
[Paclitaxel co-treated with FV-429 compound] inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]; [Paclitaxel co-treated with FV-429 compound] promotes the reaction [Oxygen deficiency results in increased expression of GSK3B protein]		 CTD PMID:19426673 PMID:34648812 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsn gelsolin decreases expression ISO Paclitaxel results in decreased expression of GSN mRNA CTD PMID:15000894 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Gsr glutathione-disulfide reductase decreases expression
multiple interactions
decreases activity		 EXP Paclitaxel results in decreased expression of GSR mRNA
parthenolide inhibits the reaction [Paclitaxel results in decreased activity of GSR protein]; parthenolide inhibits the reaction [Paclitaxel results in decreased expression of GSR mRNA]		 CTD PMID:37949423 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
decreases expression		 EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of GSTA5 mRNA] CTD PMID:37949423 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO GSTM1 gene polymorphism affects the susceptibility to [Paclitaxel co-treated with Cisplatin] CTD PMID:12851839 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm5l glutathione S-transferase, mu 5-like decreases response to substance ISO GSTM5 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance
increases response to substance		 ISO GSTP1 protein affects the susceptibility to Paclitaxel
GSTP1 mRNA results in increased susceptibility to Paclitaxel		 CTD PMID:15239142 PMID:16217747 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO GSTT1 gene polymorphism affects the susceptibility to [Paclitaxel co-treated with Cisplatin] CTD PMID:12851839 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gtf2a2 general transcription factor 2A subunit 2 increases expression EXP Paclitaxel analog results in increased expression of GTF2A2 mRNA; Paclitaxel results in increased expression of GTF2A2 mRNA CTD PMID:15585946 NCBI chr 8:70,662,447...70,675,576
Ensembl chr 8:70,662,428...70,675,569 		JBrowse link
G Gtf2i general transcription factor II I decreases expression ISO Paclitaxel results in decreased expression of GTF2I mRNA CTD PMID:15000894 NCBI chr12:22,400,933...22,476,243
Ensembl chr12:22,401,431...22,476,243 		JBrowse link
G Gtse1 G-2 and S-phase expressed 1 increases expression ISO Paclitaxel results in increased expression of GTSE1 protein CTD PMID:15907983 NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806 		JBrowse link
G Gusb glucuronidase, beta affects response to substance ISO GUSB protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO Paclitaxel results in increased expression of H2AX protein; Paclitaxel results in increased expression of H2AX protein modified form
Paclitaxel promotes the reaction [norcantharidin results in increased expression of H2AX protein modified form]; palbociclib inhibits the reaction [Paclitaxel results in increased expression of H2AX protein]		 CTD PMID:18451153 PMID:22302033 PMID:34272796 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hacl1 2-hydroxyacyl-CoA lyase 1 increases expression EXP Paclitaxel results in increased expression of HACL1 mRNA CTD PMID:15585946 NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 increases expression EXP Paclitaxel results in increased expression of HCN2 mRNA CTD PMID:36029805 NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841 		JBrowse link
G Hdac4 histone deacetylase 4 decreases expression EXP Paclitaxel results in decreased expression of HDAC4 protein CTD PMID:27474498 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac9 histone deacetylase 9 increases response to substance ISO HDAC9 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions ISO [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in increased expression of HES1 protein CTD PMID:34048126 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [FV-429 compound co-treated with Paclitaxel] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Paclitaxel co-treated with FV-429 compound co-treated with Deferoxamine] promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Paclitaxel co-treated with FV-429 compound] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; [Paclitaxel co-treated with FV-429 compound] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; HIF1A protein affects the reaction [[Paclitaxel co-treated with IL6 protein] results in increased expression of ABCB1 protein]; HIF1A protein affects the reaction [[Paclitaxel co-treated with IL6 protein] results in increased expression of ABCC1 protein]; HIF1A protein affects the reaction [IL6 protein inhibits the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; HIF1A protein affects the reaction [IL6 protein inhibits the reaction [Paclitaxel results in increased expression of BAX protein]]; HIF1A protein affects the reaction [Paclitaxel affects the reaction [Oxygen deficiency results in decreased phosphorylation of CDC25C protein]]; HIF1A protein affects the reaction [Paclitaxel inhibits the reaction [Oxygen deficiency results in decreased expression of CCNB1 protein]]; HIF1A protein affects the reaction [Paclitaxel promotes the reaction [Oxygen deficiency results in decreased phosphorylation of CDK1 protein]] CTD PMID:29341321 PMID:34648812 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmbs hydroxymethylbilane synthase decreases expression EXP Paclitaxel results in decreased expression of HMBS mRNA CTD PMID:15585946 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Hmcn1 hemicentin 1 increases response to substance ISO HMCN1 mRNA results in increased susceptibility to Paclitaxel CTD PMID:25199881 NCBI chr13:62,615,461...63,084,524
Ensembl chr13:62,615,461...63,084,524 		JBrowse link
G Hmgb1 high mobility group box 1 affects response to substance
decreases expression		 ISO
EXP		 HMGB1 protein affects the susceptibility to Paclitaxel
Paclitaxel results in decreased expression of HMGB1 protein		 CTD PMID:16217747 PMID:27474498 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression EXP Paclitaxel results in increased expression of HMGCS2 mRNA CTD PMID:15585946 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hmgn3 high mobility group nucleosomal binding domain 3 affects response to substance ISO HMGN3 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 8:84,022,493...84,059,329
Ensembl chr 8:84,022,495...84,062,976 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO Paclitaxel results in decreased expression of HMMR protein CTD PMID:15907983 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions		 EXP Paclitaxel results in decreased expression of HMOX1 mRNA
Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of HMOX1 mRNA]		 CTD PMID:35921949 PMID:36966900 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO Paclitaxel results in decreased expression of HNRNPA2B1 mRNA CTD PMID:15000894 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B decreases expression ISO Paclitaxel results in decreased expression of HNRNPAB mRNA CTD PMID:15000894 NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344 		JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression ISO Paclitaxel results in decreased expression of HNRNPH1 mRNA CTD PMID:15000894 NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of HNRNPK mRNA CTD PMID:29309887 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hook1 hook microtubule-tethering protein 1 decreases expression ISO Paclitaxel results in decreased expression of HOOK1 mRNA CTD PMID:19682730 NCBI chr 5:110,824,501...110,887,791
Ensembl chr 5:110,824,501...110,887,787 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of HRAS mRNA CTD PMID:29309887 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects response to substance ISO HSD17B4 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression EXP Paclitaxel analog results in increased expression of HSPA1L mRNA CTD PMID:15585946 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 EXP Paclitaxel results in increased expression of HSPA5 mRNA; Paclitaxel results in increased expression of HSPA5 protein
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of HSPA5 mRNA]		 CTD PMID:26732598 PMID:36966900 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspb3 heat shock protein family B (small) member 3 increases expression ISO Paclitaxel results in increased expression of HSPB3 protein CTD PMID:15907983 NCBI chr 2:45,295,285...45,295,999
Ensembl chr 2:45,295,053...45,296,145 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression		 ISO Curcumin inhibits the reaction [Paclitaxel results in increased expression of ICAM1 protein]
Paclitaxel results in decreased expression of ICAM1 mRNA; Paclitaxel results in decreased expression of ICAM1 protein		 CTD PMID:12649748 PMID:16243823 PMID:18058816 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 affects response to substance
decreases expression		 ISO IDH2 protein affects the susceptibility to Paclitaxel
Paclitaxel results in decreased expression of IDH2 mRNA		 CTD PMID:15000894 PMID:16217747 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Ier3 immediate early response 3 increases expression ISO Paclitaxel results in increased expression of IER3 mRNA CTD PMID:12929121 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Ifi30 IFI30, lysosomal thiol reductase decreases response to substance ISO IFI30 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr16:18,675,590...18,679,655
Ensembl chr16:18,675,613...18,681,175 		JBrowse link
G Ifna1 interferon, alpha 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of IFNA1 mRNA CTD PMID:29309887 NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of IFNG mRNA CTD PMID:29309887 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions
increases expression		 ISO IGFBP4 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]
Paclitaxel results in increased expression of IGFBP4 mRNA		 CTD PMID:16896004 PMID:19682730 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225 		JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 increases expression EXP Paclitaxel results in increased expression of IGFBP6 mRNA CTD PMID:18754875 NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects response to substance
multiple interactions		 ISO IKBKB protein affects the susceptibility to Paclitaxel
[Paclitaxel co-treated with Metformin] results in decreased expression of IKBKB mRNA		 CTD PMID:20159942 PMID:29309887 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
decreases expression		 ISO
EXP		 Paclitaxel results in increased expression of IL10 protein
Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of IL10 protein]
[1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine co-treated with Paclitaxel] results in increased expression of IL10 protein		 CTD PMID:14698135 PMID:30414958 PMID:36898573 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A multiple interactions
increases expression		 ISO CD14 protein affects the reaction [Paclitaxel results in increased expression of IL12A mRNA]; ITGAM protein affects the reaction [Paclitaxel results in increased expression of IL12A mRNA]; ITGAM protein affects the reaction [Paclitaxel results in increased secretion of [IL12A protein binds to IL12B protein]]; Paclitaxel results in increased secretion of [IL12A protein binds to IL12B protein]; TLR4 protein affects the reaction [Paclitaxel results in increased expression of IL12A mRNA] CTD PMID:11123339 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression		 ISO CD14 protein affects the reaction [Paclitaxel results in increased expression of IL12B mRNA]; ITGAM protein affects the reaction [Paclitaxel results in increased secretion of [IL12A protein binds to IL12B protein]]; Paclitaxel results in increased secretion of [IL12A protein binds to IL12B protein]; TLR4 protein affects the reaction [Paclitaxel results in increased expression of IL12B mRNA] CTD PMID:11123339 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 affects response to substance ISO IL13RA2 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381 		JBrowse link
G Il17rb interleukin 17 receptor B decreases response to substance ISO IL17RB protein results in decreased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125 		JBrowse link
G Il18 interleukin 18 multiple interactions
increases secretion
increases expression		 ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of IL18 mRNA; benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paclitaxel results in increased expression of IL18 mRNA]; benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paclitaxel results in increased secretion of IL18 protein] CTD PMID:20705681 PMID:31993881 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
increases secretion		 EXP
ISO		 Paclitaxel results in increased expression of IL1B mRNA; Paclitaxel results in increased expression of IL1B protein
Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]; necrostatin-1 inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]
Paclitaxel results in increased secretion of IL1B protein
benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paclitaxel results in increased expression of and results in increased cleavage of IL1B protein]; benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paclitaxel results in increased expression of IL1B mRNA]; benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paclitaxel results in increased secretion of IL1B protein]; Paclitaxel results in increased expression of and results in increased cleavage of IL1B protein		 CTD PMID:17174526 PMID:28242239 PMID:31993881 PMID:34056794 PMID:35921949 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO Paclitaxel results in decreased expression of IL1R1 protein CTD PMID:15907983 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il20 interleukin 20 increases expression
multiple interactions		 EXP Paclitaxel results in increased expression of IL20 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of IL20 protein]]; Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of IL20 protein]		 CTD PMID:35662665 NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
affects response to substance		 ISO
EXP		 Paclitaxel results in increased expression of IL6 protein
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL6 mRNA]
Paclitaxel results in increased expression of IL6 mRNA; Paclitaxel results in increased expression of IL6 protein
[Paclitaxel co-treated with IL6 protein] results in increased expression of ABCB1 protein; [Paclitaxel co-treated with IL6 protein] results in increased expression of ABCC1 protein; HIF1A protein affects the reaction [[Paclitaxel co-treated with IL6 protein] results in increased expression of ABCB1 protein]; HIF1A protein affects the reaction [[Paclitaxel co-treated with IL6 protein] results in increased expression of ABCC1 protein]; HIF1A protein affects the reaction [IL6 protein inhibits the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; HIF1A protein affects the reaction [IL6 protein inhibits the reaction [Paclitaxel results in increased expression of BAX protein]]; IL6 protein inhibits the reaction [Paclitaxel results in decreased expression of BCL2 protein]; IL6 protein inhibits the reaction [Paclitaxel results in increased expression of BAX protein]
TLR4 protein mutant form inhibits the reaction [Paclitaxel results in increased expression of IL6 mRNA]
IL6 protein affects the susceptibility to Paclitaxel		 CTD PMID:14698135 PMID:18270703 PMID:28242239 PMID:29341321 PMID:30414958 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Insig1 insulin induced gene 1 affects response to substance ISO INSIG1 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Ip6k1 inositol hexakisphosphate kinase 1 decreases expression EXP Paclitaxel results in decreased expression of IP6K1 mRNA CTD PMID:15585946 NCBI chr 8:108,693,068...108,737,278 JBrowse link
G Irf1 interferon regulatory factor 1 increases expression EXP Taxol increases expression of Irf1 mRNA and protein in astrocytoma cells and astrocytes RGD PMID:15141302 RGD:5128786 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of IRF3 mRNA CTD PMID:29309887 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Irf5 interferon regulatory factor 5 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of IRF5 mRNA CTD PMID:29309887 NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267 		JBrowse link
G Irf7 interferon regulatory factor 7 increases expression
multiple interactions		 EXP
ISO		 Paclitaxel results in increased expression of IRF7 mRNA
[Paclitaxel co-treated with Metformin] results in increased expression of IRF7 mRNA		 CTD PMID:15585946 PMID:29309887 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Irf8 interferon regulatory factor 8 increases expression
multiple interactions		 ISO
EXP		 Paclitaxel results in increased expression of IRF8 mRNA
Paclitaxel results in increased expression of IRF8 mRNA; Paclitaxel results in increased expression of IRF8 protein
1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased expression of IRF8 mRNA]; 1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased expression of IRF8 protein]; Paclitaxel promotes the reaction [RELA protein binds to IRF8 promoter]
TLR4 protein affects the reaction [Paclitaxel results in increased expression of IRF8 mRNA]		 CTD PMID:11123339 PMID:30414958 NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier affects response to substance ISO ISG15 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Itga1 integrin subunit alpha 1 increases response to substance ISO ITGA1 mRNA results in increased susceptibility to Paclitaxel CTD PMID:25199881 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Itga2 integrin subunit alpha 2 increases response to substance EXP ITGA2 protein results in increased susceptibility to Paclitaxel CTD PMID:18234883 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO Paclitaxel results in decreased expression of ITGAL mRNA; Paclitaxel results in decreased expression of ITGAL protein CTD PMID:12649748 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions
increases expression		 ISO
EXP		 ITGAM protein affects the reaction [Paclitaxel affects the localization of and results in increased activity of [NFKB1 protein binds to RELA protein]]; ITGAM protein affects the reaction [Paclitaxel results in increased expression of IL12A mRNA]; ITGAM protein affects the reaction [Paclitaxel results in increased expression of PTGS2 mRNA]; ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein]; ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK3 protein]; ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK8 protein]; ITGAM protein affects the reaction [Paclitaxel results in increased secretion of [IL12A protein binds to IL12B protein]]
Paclitaxel results in increased expression of ITGAM mRNA		 CTD PMID:11123339 PMID:17174526 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance EXP ITGB1 results in increased susceptibility to Paclitaxel CTD PMID:14984413 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 affects response to substance ISO ITGB1BP1 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037 		JBrowse link
G Itgb5 integrin subunit beta 5 decreases response to substance ISO ITGB5 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472 		JBrowse link
G Itgb6 integrin subunit beta 6 decreases expression ISO Paclitaxel results in decreased expression of ITGB6 mRNA CTD PMID:19682730 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671 		JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 increases expression ISO Paclitaxel results in increased expression of ITIH2 mRNA CTD PMID:12929121 NCBI chr17:68,375,574...68,411,849
Ensembl chr17:68,375,567...68,411,841 		JBrowse link
G Itm2b integral membrane protein 2B affects response to substance ISO ITM2B protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
increases expression		 ISO
EXP		 Paclitaxel results in increased phosphorylation of JUN protein
Paclitaxel results in increased expression of JUN protein		 CTD PMID:15585644 PMID:17686523 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 increases expression EXP Paclitaxel results in increased expression of KCNJ16 mRNA CTD PMID:18754875 NCBI chr10:95,990,009...96,021,356
Ensembl chr10:95,960,725...96,021,702 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 increases expression ISO Paclitaxel results in increased expression of KCNK3 protein CTD PMID:15907983 NCBI chr 6:25,761,487...25,799,153
Ensembl chr 6:25,763,228...25,799,153 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 affects response to substance ISO KCNMA1 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198 		JBrowse link
G Kcns1 potassium voltage-gated channel, modifier subfamily S, member 1 decreases expression EXP Paclitaxel results in decreased expression of KCNS1 mRNA CTD PMID:36029805 NCBI chr 3:152,835,642...152,843,032
Ensembl chr 3:152,835,644...152,842,960 		JBrowse link
G Kdm4b lysine demethylase 4B multiple interactions ISO KDM4B mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 9:1,158,737...1,237,233
Ensembl chr 9:1,158,752...1,236,543 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 protein results in decreased stability of NFE2L2 protein] which results in increased susceptibility to Paclitaxel CTD PMID:20530669 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Kif3a kinesin family member 3a multiple interactions ISO KIF3A mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:37,725,930...37,761,183
Ensembl chr10:37,725,970...37,759,191 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of KIT mRNA; [Cisplatin co-treated with Paclitaxel] results in increased expression of KIT protein CTD PMID:20705681 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Kl Klotho multiple interactions
decreases expression		 ISO Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of KL protein] CTD PMID:36898573 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions ISO [Paclitaxel co-treated with Carboplatin] results in decreased expression of KLK3 protein; Paclitaxel inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] CTD PMID:16442593 PMID:20807808 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of KRAS mRNA CTD PMID:29309887 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt13 keratin 13 decreases response to substance ISO KRT13 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr10:85,051,887...85,056,099
Ensembl chr10:85,051,889...85,056,084 		JBrowse link
G Krt18 keratin 18 increases expression ISO Paclitaxel results in increased expression of KRT18 protein modified form CTD PMID:22907900 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166 		JBrowse link
G Krt19 keratin 19 increases expression EXP Paclitaxel results in increased expression of KRT19 mRNA CTD PMID:18754875 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt23 keratin 23 increases response to substance ISO KRT23 mRNA results in increased susceptibility to Paclitaxel CTD PMID:25199881 NCBI chr10:84,434,445...84,450,773
Ensembl chr10:84,434,380...84,450,983 		JBrowse link
G Krt7 keratin 7 increases response to substance ISO KRT7 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052 		JBrowse link
G Lama2 laminin subunit alpha 2 increases response to substance ISO LAMA2 mRNA results in increased susceptibility to Paclitaxel CTD PMID:25199881 NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 affects response to substance ISO LAMP2 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Paclitaxel results in increased expression of LBP mRNA CTD PMID:18754875 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 increases expression ISO Paclitaxel results in increased expression of LCP2 protein CTD PMID:15907983 NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559 		JBrowse link
G Ldha lactate dehydrogenase A increases response to substance
increases expression
multiple interactions		 ISO
EXP		 LDHA mutant form results in increased susceptibility to Paclitaxel
Paclitaxel analog results in increased expression of LDHA mRNA; Paclitaxel results in increased expression of LDHA mRNA
[Oxamic Acid results in decreased activity of LDHA protein] which results in increased susceptibility to Paclitaxel		 CTD PMID:15585946 PMID:21332213 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldlr low density lipoprotein receptor affects response to substance ISO LDLR protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lgals4 galectin 4 decreases response to substance ISO LGALS4 protein results in decreased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 1:84,124,766...84,132,481
Ensembl chr 1:84,124,764...84,132,481 		JBrowse link
G Lifr LIF receptor subunit alpha multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of LIFR mRNA CTD PMID:20705681 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699 		JBrowse link
G Lig1 DNA ligase 1 decreases expression ISO Paclitaxel results in decreased expression of LIG1 mRNA CTD PMID:15000894 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413 		JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 increases expression EXP Paclitaxel results in increased expression of LILRB4 mRNA CTD PMID:18754875 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660 		JBrowse link
G Lingo3 leucine rich repeat and Ig domain containing 3 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of LINGO3 mRNA CTD PMID:29309887 NCBI chr 7:8,869,025...8,878,431
Ensembl chr 7:8,869,025...8,878,431 		JBrowse link
G Litaf lipopolysaccharide-induced TNF factor affects response to substance ISO LITAF protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763 		JBrowse link
G Lox lysyl oxidase multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of LOX mRNA CTD PMID:20705681 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of LRP5 mRNA CTD PMID:20705681 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581 		JBrowse link
G Lrp6 LDL receptor related protein 6 multiple interactions ISO [Paclitaxel co-treated with FV-429 compound] inhibits the reaction [Oxygen deficiency results in increased expression of LRP6 protein] CTD PMID:34648812 NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 affects response to substance ISO LTBP2 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208 		JBrowse link
G Lum lumican multiple interactions
decreases response to substance		 ISO [Cisplatin co-treated with Paclitaxel] affects the expression of LUM mRNA
LUM mRNA results in decreased susceptibility to Paclitaxel		 CTD PMID:20705681 PMID:25199881 NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793 		JBrowse link
G Ly6c Ly6-C antigen increases expression EXP Paclitaxel results in increased expression of LY6C mRNA CTD PMID:15585946 NCBI chr 7:106,959,508...106,963,329
Ensembl chr 7:106,959,511...106,963,329 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 affects response to substance
decreases expression		 ISO MAD2L1 protein affects the susceptibility to Paclitaxel
Paclitaxel results in decreased expression of MAD2L1 mRNA		 CTD PMID:12929121 PMID:18691855 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Madd MAP-kinase activating death domain decreases expression ISO Paclitaxel results in decreased expression of MADD mRNA CTD PMID:15000894 NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression
multiple interactions		 EXP Paclitaxel results in increased expression of MAP1LC3A mRNA
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAP1LC3A mRNA]		 CTD PMID:35921949 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions		 ISO
EXP		 Paclitaxel results in increased expression of MAP1LC3B mRNA; Paclitaxel results in increased expression of MAP1LC3B protein
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAP1LC3B mRNA]		 CTD PMID:19815708 PMID:35921949 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; [MAP2K1 protein affects the activity of [MAPK1 protein co-treated with MAPK3 protein]] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; [Tretinoin co-treated with Paclitaxel] results in decreased expression of MAP2K1 protein CTD PMID:18098270 PMID:18594523 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of MAP2K3 mRNA CTD PMID:29309887 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO MAP2K4 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein]; MAP2K4 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein] CTD PMID:10075725 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 multiple interactions
increases cleavage
affects localization		 ISO aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Paclitaxel results in increased cleavage of MAP3K1 protein]; MAP3K1 protein affects the reaction [Paclitaxel results in increased activity of MAPK8 protein]; MAP3K1 protein affects the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Paclitaxel promotes the reaction [MAPK8 protein binds to MAP3K1 protein modified form]
Paclitaxel affects the localization of MAP3K1 protein		 CTD PMID:11160861 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Map3k2 mitogen activated protein kinase kinase kinase 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K2 mRNA CTD PMID:29309887 NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO MAP3K5 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein]; MAP3K5 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein] CTD PMID:10075725 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K7 mRNA CTD PMID:29309887 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
increases activity
decreases activity		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK1 protein; [MAP2K1 protein affects the activity of [MAPK1 protein co-treated with MAPK3 protein]] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; [PD168393 co-treated with Paclitaxel] results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; Paclitaxel results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Paclitaxel results in increased phosphorylation of and results in increased activity of MAPK1 protein; Paclitaxel results in increased phosphorylation of and results in increased expression of MAPK1 protein; SOD2 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in decreased phosphorylation of MAPK1 protein]]; Trimetazidine inhibits the reaction [Paclitaxel results in decreased phosphorylation of MAPK1 protein]
CD14 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein]; ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein]
Paclitaxel results in decreased activity of MAPK1 protein		 CTD PMID:11123339 PMID:12510025 PMID:15907805 PMID:16051289 PMID:16211241 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 increases expression ISO Paclitaxel results in increased expression of MAPK13 protein CTD PMID:15907983 NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
increases phosphorylation
increases expression		 ISO
EXP		 [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK14 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of MAPK14 mRNA
Trimetazidine inhibits the reaction [Paclitaxel results in increased phosphorylation of MAPK14 protein]
Paclitaxel results in increased expression of MAPK14 mRNA
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAPK14 mRNA]		 CTD PMID:16051289 PMID:29309887 PMID:35921949 PMID:36898573 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
increases activity		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of MAPK3 protein]; 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Paclitaxel results in increased activity of MAPK3 protein]; [esculetin co-treated with Paclitaxel] results in decreased expression of MAPK3 protein; [MAP2K1 protein affects the activity of [MAPK1 protein co-treated with MAPK3 protein]] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; [PD168393 co-treated with Paclitaxel] results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; [Tretinoin co-treated with Paclitaxel] results in increased phosphorylation of MAPK3 protein; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK3 protein]; Paclitaxel results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; Paclitaxel results in increased phosphorylation of and results in increased activity of MAPK3 protein; Paclitaxel results in increased phosphorylation of and results in increased expression of MAPK3 protein; SOD2 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Paclitaxel results in increased activity of MAPK3 protein]
Paclitaxel results in decreased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in decreased phosphorylation of MAPK3 protein]]; Trimetazidine inhibits the reaction [Paclitaxel results in decreased phosphorylation of MAPK3 protein]
CD14 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK3 protein]; ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11123339 PMID:12510025 PMID:15907805 PMID:16051289 PMID:16211241 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases expression
increases activity		 ISO [esculetin co-treated with Paclitaxel] results in increased expression of MAPK8 protein; [Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK8 protein; aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Paclitaxel results in increased activity of MAPK8 protein]; epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK8 protein]; MAP3K1 protein affects the reaction [Paclitaxel results in increased activity of MAPK8 protein]; MAPK8 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein]; MAPK8 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; MAPK8 protein affects the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Paclitaxel promotes the reaction [MAPK8 protein binds to MAP3K1 protein modified form]
Paclitaxel results in increased phosphorylation of MAPK8 protein
CD14 protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK8 protein]; ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK8 protein]
Paclitaxel results in increased expression of MAPK8 protein		 CTD PMID:10075725 PMID:11123339 PMID:11160861 PMID:16051289 PMID:19426673 More... NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases expression		 ISO
EXP		 [esculetin co-treated with Paclitaxel] results in increased expression of MAPK9 protein; [Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK9 protein; epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK9 protein]
Paclitaxel results in increased expression of MAPK9 protein
Paclitaxel analog results in increased expression of MAPK9 mRNA		 CTD PMID:15585946 PMID:16051289 PMID:19944065 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 affects response to substance ISO MAPKAPK5 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr12:34,993,520...35,013,059
Ensembl chr12:34,994,092...35,013,052 		JBrowse link
G Mapre1 microtubule-associated protein, RP/EB family, member 1 multiple interactions
decreases localization		 ISO olesoxime inhibits the reaction [Paclitaxel results in decreased localization of MAPRE1 protein] CTD PMID:20417191 NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983 		JBrowse link
G Mapre3 microtubule-associated protein, RP/EB family, member 3 affects localization
multiple interactions		 ISO Paclitaxel affects the localization of MAPRE3 protein
olesoxime inhibits the reaction [Paclitaxel results in decreased localization of MAPRE3 protein]		 CTD PMID:20417191 NCBI chr 6:25,513,800...25,558,876
Ensembl chr 6:25,513,800...25,558,881 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
decreases expression		 ISO
EXP		 MAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]
Paclitaxel inhibits the reaction [annonacin affects the localization of MAPT protein]
Paclitaxel results in decreased expression of MAPT mRNA; Paclitaxel results in decreased expression of MAPT protein		 CTD PMID:16896004 PMID:16930453 PMID:17634376 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Marveld1 MARVEL domain containing 1 increases response to substance ISO MARVELD1 protein results in increased susceptibility to Paclitaxel CTD PMID:27447558 NCBI chr 1:240,954,050...240,958,101
Ensembl chr 1:240,954,452...240,958,384 		JBrowse link
G Matk megakaryocyte-associated tyrosine kinase multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of MATK mRNA CTD PMID:20705681 NCBI chr 7:8,456,990...8,465,947
Ensembl chr 7:8,456,998...8,462,022 		JBrowse link
G Matn2 matrilin 2 multiple interactions
decreases response to substance		 ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of MATN2 mRNA
MATN2 mRNA results in decreased susceptibility to Paclitaxel		 CTD PMID:20705681 PMID:25199881 NCBI chr 7:65,494,996...65,644,613
Ensembl chr 7:65,494,834...65,645,113 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Paclitaxel results in decreased expression of MCL1 protein CTD PMID:14749477 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases response to substance ISO MDM2 protein results in decreased susceptibility to Paclitaxel CTD PMID:13130078 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO Paclitaxel promotes the reaction [NR1I2 protein binds to MED1 protein] CTD PMID:15650019 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Med13l mediator complex subunit 13L multiple interactions ISO MED13L mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr12:37,807,596...38,004,886
Ensembl chr12:37,808,285...38,004,473 		JBrowse link
G Med4 mediator complex subunit 4 affects response to substance ISO MED4 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr15:48,696,542...48,706,818
Ensembl chr15:48,696,511...48,706,820 		JBrowse link
G Melk maternal embryonic leucine zipper kinase multiple interactions ISO MELK mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937 		JBrowse link
G Men1 menin 1 increases expression EXP Paclitaxel results in increased expression of MEN1 mRNA CTD PMID:15585946 NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871 		JBrowse link
G Metrn meteorin, glial cell differentiation regulator multiple interactions ISO METRN mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr10:14,816,684...14,818,702
Ensembl chr10:14,816,572...14,818,701 		JBrowse link
G Mfap5 microfibril associated protein 5 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of MFAP5 mRNA CTD PMID:20705681 NCBI chr 4:155,727,925...155,750,458
Ensembl chr 4:155,727,925...155,750,458 		JBrowse link
G Mfn2 mitofusin 2 decreases expression EXP Paclitaxel results in decreased expression of MFN2 mRNA CTD PMID:28587902 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression ISO Paclitaxel results in increased expression of MGMT mRNA CTD PMID:12929121 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Miat myocardial infarction associated transcript decreases response to substance
multiple interactions		 ISO MIAT results in decreased susceptibility to Paclitaxel
MIAT affects the reaction [TAF1 protein affects the susceptibility to Paclitaxel]; TAF1 protein affects the reaction [MIAT results in decreased susceptibility to Paclitaxel]		 CTD PMID:37132394 NCBI chr12:44,414,620...44,429,852 JBrowse link
G Micb MHC class I polypeptide-related sequence B increases response to substance ISO MICB protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 1:78,495,779...78,513,030
Ensembl chr 1:78,495,779...78,512,827 		JBrowse link
G Mir20a microRNA 20a decreases expression ISO Paclitaxel results in decreased expression of MIR20A CTD PMID:35134991 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir365b microRNA 365b decreases expression ISO Paclitaxel results in decreased expression of MIR365B CTD PMID:35134991 NCBI chr10:64,686,255...64,686,340
Ensembl chr10:64,686,252...64,686,351 		JBrowse link
G Mir433 microRNA 433 increases expression ISO Paclitaxel results in increased expression of MIR433 CTD PMID:35134991 NCBI chr 6:128,545,119...128,545,211
Ensembl chr 6:128,545,112...128,545,217 		JBrowse link
G Mir488 microRNA 488 increases expression ISO Paclitaxel results in increased expression of MIR488 CTD PMID:35134991 NCBI chr13:70,683,064...70,683,142
Ensembl chr13:70,683,064...70,683,142 		JBrowse link
G Mir874 microRNA 874 increases response to substance ISO MIR874 mRNA results in increased susceptibility to Paclitaxel CTD PMID:30004169 NCBI chr17:6,620,649...6,620,724
Ensembl chr17:6,620,649...6,620,724 		JBrowse link
G Mlec malectin affects response to substance ISO MLEC protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr12:41,458,234...41,468,710
Ensembl chr12:41,458,231...41,468,708 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase increases expression
multiple interactions		 EXP Paclitaxel results in increased expression of MLKL protein
Minocycline inhibits the reaction [Paclitaxel results in increased expression of MLKL protein]; necrostatin-1 inhibits the reaction [Paclitaxel results in increased expression of MLKL protein]		 CTD PMID:34056794 PMID:38459698 NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502 		JBrowse link
G Mmp1 matrix metallopeptidase 1 affects response to substance
multiple interactions		 ISO MMP1 protein affects the susceptibility to Paclitaxel
[Cisplatin co-treated with Paclitaxel] results in decreased expression of MMP1 mRNA		 CTD PMID:16217747 PMID:20705681 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp10 matrix metallopeptidase 10 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of MMP10 mRNA CTD PMID:20705681 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748 		JBrowse link
G Mmp16 matrix metallopeptidase 16 decreases expression ISO Paclitaxel results in decreased expression of MMP16 mRNA CTD PMID:18058816 NCBI chr 5:31,312,280...31,556,276
Ensembl chr 5:31,312,280...31,548,388 		JBrowse link
G Mmp17 matrix metallopeptidase 17 decreases expression ISO Paclitaxel results in decreased expression of MMP17 mRNA CTD PMID:18058816 NCBI chr12:27,074,398...27,099,317
Ensembl chr12:27,074,409...27,099,316 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression		 ISO
EXP		 [Cisplatin co-treated with Paclitaxel] results in increased expression of MMP2 mRNA
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP2 mRNA]		 CTD PMID:20705681 PMID:35921949 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression
multiple interactions		 EXP
ISO		 Paclitaxel results in increased expression of MMP3; Paclitaxel results in increased expression of MMP3 mRNA
[Cisplatin co-treated with Paclitaxel] results in increased expression of MMP3 mRNA		 CTD PMID:18754875 PMID:20705681 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO
EXP		 [Cisplatin co-treated with Paclitaxel] results in increased expression of MMP9 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MMP9 protein]
Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of MMP9 protein]
Paclitaxel results in increased expression of MMP9 mRNA
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP9 mRNA]		 CTD PMID:16243823 PMID:20705681 PMID:35921949 PMID:36898573 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mok MOK protein kinase affects response to substance ISO MOK protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 6:129,823,794...129,854,669
Ensembl chr 6:129,823,795...129,854,700 		JBrowse link
G Mphosph6 M phase phosphoprotein 6 decreases expression ISO Paclitaxel results in decreased expression of MPHOSPH6 protein CTD PMID:15907983 NCBI chr19:45,860,152...45,870,117
Ensembl chr19:45,860,154...45,870,170 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of MPO protein]]; Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of MPO protein] CTD PMID:35662665 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mpp3 MAGUK p55 scaffold protein 3 increases expression ISO Paclitaxel results in increased expression of MPP3 protein CTD PMID:15907983 NCBI chr10:86,945,705...86,975,261
Ensembl chr10:86,945,714...86,974,737 		JBrowse link
G Mpzl2 myelin protein zero-like 2 decreases expression
increases expression		 ISO
EXP		 Paclitaxel results in decreased expression of MPZL2 mRNA
Paclitaxel results in increased expression of MPZL2 mRNA		 CTD PMID:18754875 PMID:19682730 NCBI chr 8:45,348,285...45,359,298
Ensembl chr 8:45,348,285...45,359,298 		JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression EXP Paclitaxel results in increased expression of MRC1 mRNA CTD PMID:18754875 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857 		JBrowse link
G Mrpl40 mitochondrial ribosomal protein L40 affects response to substance ISO MRPL40 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr11:82,133,398...82,139,234
Ensembl chr11:82,133,398...82,139,233 		JBrowse link
G Mrpl57 mitochondrial ribosomal protein L57 affects response to substance ISO MRPL57 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr15:31,970,904...31,971,766
Ensembl chr15:31,970,860...31,973,993 		JBrowse link
G Mrps15 mitochondrial ribosomal protein S15 affects response to substance ISO MRPS15 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 5:138,321,610...138,332,205
Ensembl chr 5:138,321,593...138,332,205 		JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B decreases expression ISO Paclitaxel results in decreased expression of MRPS18B protein CTD PMID:15907983 NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects response to substance ISO MSMO1 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Mt1-ps3 metallothionein 1, pseudogene 3 increases response to substance ISO MT1E mRNA results in increased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135 		JBrowse link
G Mt2A metallothionein 2A increases response to substance ISO MT2A mRNA results in increased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
decreases phosphorylation		 ISO Paclitaxel results in increased phosphorylation of MTOR protein
Paclitaxel results in decreased phosphorylation of MTOR protein		 CTD PMID:27769712 PMID:36683349 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Muc16 mucin 16, cell surface associated multiple interactions
decreases expression		 ISO [Paclitaxel co-treated with Cisplatin] results in decreased expression of MUC16 protein
Paclitaxel results in decreased expression of MUC16 protein		 CTD PMID:8751544 PMID:11706781 NCBI chr 8:16,164,531...16,323,126 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
affects response to substance		 ISO
EXP		 [Cisplatin co-treated with Paclitaxel] results in decreased expression of MYC mRNA; [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in increased expression of MYC protein; [Paclitaxel co-treated with Metformin] results in decreased expression of MYC mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MYC protein]
royal jelly inhibits the reaction [Paclitaxel results in decreased expression of MYC mRNA]
MYC protein affects the susceptibility to Paclitaxel
Paclitaxel results in decreased expression of MYC protein		 CTD PMID:15907983 PMID:16243823 PMID:18802399 PMID:20705681 PMID:27496854 More... NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myo5a myosin VA increases response to substance ISO MYO5A protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions
decreases expression		 ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of NAMPT mRNA
Paclitaxel results in decreased expression of NAMPT mRNA		 CTD PMID:12929121 PMID:20705681 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nanog Nanog homeobox multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of NANOG mRNA; [Cisplatin co-treated with Paclitaxel] results in increased expression of NANOG protein CTD PMID:20705681 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity
decreases expression		 ISO Paclitaxel results in decreased activity of NAT1 mRNA; Paclitaxel results in decreased activity of NAT1 protein
Paclitaxel results in decreased expression of NAT1 mRNA		 CTD PMID:15015580 PMID:17564303 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nav3 neuron navigator 3 affects response to substance ISO NAV3 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 7:45,052,206...45,840,471
Ensembl chr 7:45,054,296...45,840,698 		JBrowse link
G Ncapg non-SMC condensin I complex, subunit G affects response to substance ISO NCAPG protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:16819505 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA3 protein] CTD PMID:15650019 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 affects response to substance ISO NDUFA1 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr  X:116,424,223...116,427,875
Ensembl chr  X:116,424,223...116,428,633 		JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 affects response to substance ISO NDUFA13 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726
Ensembl chr 7:19,526,565...19,535,726 		JBrowse link
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 affects response to substance ISO NDUFA3 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 1:65,597,567...65,600,197
Ensembl chr 1:65,597,578...65,600,235 		JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 affects response to substance ISO NDUFB2 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851
Ensembl chr 4:46,536,062...46,536,851 		JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 affects response to substance ISO NDUFB7 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr19:24,568,241...24,572,579
Ensembl chr19:24,568,241...24,572,579 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions ISO Paclitaxel inhibits the reaction [NDUFS4 protein affects the reaction [Rotenone results in increased abundance of Dopamine]]; Paclitaxel inhibits the reaction [NDUFS4 protein affects the reaction [Rotenone results in increased abundance of Reactive Oxygen Species]] CTD PMID:21383081 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846 		JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 affects response to substance ISO NDUFS8 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 decreases expression ISO Paclitaxel results in decreased expression of NDUFV1 mRNA CTD PMID:15000894 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466 		JBrowse link
G Nefl neurofilament light chain increases expression
multiple interactions		 EXP Paclitaxel results in increased expression of NEFL protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of NEFL protein]]; Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of NEFL protein]		 CTD PMID:35662665 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nes nestin multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of NES mRNA CTD PMID:20705681 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777 		JBrowse link
G Neurod4 neuronal differentiation 4 decreases expression ISO Paclitaxel results in decreased expression of NEUROD4 mRNA CTD PMID:12929121 NCBI chr 7:7,090,048...7,102,018
Ensembl chr 7:7,090,045...7,102,030 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases response to substance
multiple interactions
decreases expression		 ISO
EXP		 NFE2L2 results in decreased susceptibility to Paclitaxel
Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of NFE2L2 mRNA]
[KEAP1 protein results in decreased stability of NFE2L2 protein] which results in increased susceptibility to Paclitaxel		 CTD PMID:15585946 PMID:20530669 PMID:35921949 PMID:36966900 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression		 ISO
EXP		 ITGAM protein affects the reaction [Paclitaxel affects the localization of and results in increased activity of [NFKB1 protein binds to RELA protein]]; Paclitaxel affects the localization of and results in increased activity of [NFKB1 protein binds to RELA protein]
Paclitaxel results in increased expression of NFKB1 mRNA
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of NFKB1 mRNA]
[Paclitaxel co-treated with Metformin] results in decreased expression of NFKB1 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased activity of NFKB1 protein]		 CTD PMID:11123339 PMID:16243823 PMID:29309887 PMID:35921949 PMID:36966900 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of NFKB2 mRNA CTD PMID:29309887 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Curcumin inhibits the reaction [Paclitaxel results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:16243823 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor decreases response to substance
multiple interactions
decreases expression		 EXP NGF protein results in decreased susceptibility to Paclitaxel
Tretinoin inhibits the reaction [Paclitaxel results in decreased expression of NGF protein]		 CTD PMID:9622663 PMID:10553948 PMID:21865574 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nkain1 Sodium/potassium transporting ATPase interacting 1 multiple interactions ISO NKAIN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide] CTD PMID:16896004 NCBI chr 5:142,747,702...142,792,665
Ensembl chr 5:142,747,505...142,791,863 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 increases expression EXP Paclitaxel results in increased expression of NME1 mRNA CTD PMID:15585946 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Nme4 NME/NM23 nucleoside diphosphate kinase 4 decreases expression ISO Paclitaxel results in decreased expression of NME4 protein CTD PMID:15907983 NCBI chr10:15,114,624...15,118,479
Ensembl chr10:15,002,926...15,118,479 		JBrowse link
G Nmrk2 nicotinamide riboside kinase 2 decreases response to substance ISO ITGB1BP3 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:25199881 NCBI chr 7:8,514,855...8,517,916
Ensembl chr 7:8,514,927...8,517,922 		JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of NOD1 mRNA CTD PMID:29309887 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404 		JBrowse link
G Nop58 NOP58 ribonucleoprotein decreases expression ISO Paclitaxel results in decreased expression of NOL5 mRNA CTD PMID:12929121 NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP parthenolide inhibits the reaction [Paclitaxel results in increased expression of NOS2 protein] CTD PMID:37949423 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
multiple interactions		 ISO Paclitaxel results in decreased expression of NOS3 mRNA; Paclitaxel results in decreased expression of NOS3 protein
Aspirin inhibits the reaction [Paclitaxel results in decreased expression of NOS3 protein]; cilostazol inhibits the reaction [Paclitaxel results in decreased expression of NOS3 protein]		 CTD PMID:19520256 PMID:19815708 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Notch1 notch receptor 1 multiple interactions
decreases expression
decreases response to substance		 ISO
EXP		 [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in decreased expression of CASP9 protein modified form; [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in increased expression of CCNE1 protein; [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in increased expression of CDH2 protein; [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in increased expression of FN1 protein; [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in increased expression of HES1 protein; [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in increased expression of MYC protein; [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in increased expression of VIM protein; [NOTCH1 protein results in decreased susceptibility to Paclitaxel] which results in increased expression of ZEB1 protein
Paclitaxel results in decreased expression of NOTCH1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of NOTCH1 mRNA]]; Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of NOTCH1 mRNA]		 CTD PMID:34048126 PMID:35662665 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Npm1 nucleophosmin 1 decreases response to substance ISO NPM1 protein results in decreased susceptibility to Paclitaxel CTD PMID:24736981 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
Ensembl chr  X:17,739,941...17,751,645 		JBrowse link
G Npy neuropeptide Y increases expression EXP Paclitaxel results in increased expression of NPY protein CTD PMID:17686523 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
increases abundance
multiple interactions		 ISO Paclitaxel results in increased activity of NR1I2 protein
NR1I2 gene mutant form results in increased abundance of Paclitaxel
[Paclitaxel results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; [SR 12813 results in increased activity of NR1I2 protein] which results in decreased susceptibility to Paclitaxel; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased activity of NR1I2 protein]; NR1I2 protein promotes the reaction [Paclitaxel results in increased expression of and results in increased activity of ABCB1 protein]; Paclitaxel binds to and results in increased activity of NR1I2 protein; Paclitaxel promotes the reaction [NR1I2 protein binds to MED1 protein]; Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]; Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA3 protein]		 CTD PMID:12065438 PMID:14977870 PMID:15650019 PMID:15864135 PMID:16819505 More... NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nras NRAS proto-oncogene, GTPase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of NRAS mRNA CTD PMID:29309887 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Nrp1 neuropilin 1 increases expression ISO Paclitaxel results in increased expression of NRP1 mRNA CTD PMID:19682730 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nudt12 nudix hydrolase 12 increases expression ISO Paclitaxel results in increased expression of NUDT12 mRNA CTD PMID:12929121 NCBI chr 9:98,741,627...98,755,039
Ensembl chr 9:98,742,360...98,755,039 		JBrowse link
G Nudt15 nudix hydrolase 15 affects response to substance ISO NUDT15 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr15:48,707,776...48,713,847
Ensembl chr15:48,709,700...48,747,363 		JBrowse link
G Nudt4 nudix hydrolase 4 affects response to substance ISO NUDT4 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 7:30,188,100...30,204,615
Ensembl chr 7:30,188,100...30,204,615 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP Paclitaxel results in increased expression of NUPR1 mRNA CTD PMID:18754875 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit decreases expression ISO Paclitaxel results in decreased expression of NUS1 mRNA CTD PMID:12929121 NCBI chr20:31,811,817...31,838,562
Ensembl chr20:31,811,817...31,838,561 		JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 affects response to substance ISO NUSAP1 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624 		JBrowse link
G Oat ornithine aminotransferase increases expression EXP Paclitaxel analog results in increased expression of OAT mRNA; Paclitaxel results in increased expression of OAT mRNA CTD PMID:15585946 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Obp3 alpha-2u globulin PGCL4 increases expression EXP Paclitaxel results in increased expression of OBP3 mRNA CTD PMID:18754875 NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757 		JBrowse link
G Ocln occludin multiple interactions ISO [glabridin co-treated with Paclitaxel] results in increased expression of OCLN protein CTD PMID:37419298 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression ISO Paclitaxel results in increased expression of OGG1 protein CTD PMID:15907983 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Ogn osteoglycin multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of OGN mRNA CTD PMID:20705681 NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739 		JBrowse link
G Olfml3 olfactomedin-like 3 increases expression ISO Paclitaxel results in increased expression of OLFML3 mRNA CTD PMID:19682730 NCBI chr 2:191,244,221...191,247,050
Ensembl chr 2:191,244,221...191,247,050 		JBrowse link
G Osbpl10 oxysterol binding protein-like 10 affects response to substance ISO OSBPL10 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 8:114,661,050...114,918,664
Ensembl chr 8:114,660,743...114,918,625 		JBrowse link
G Osmr oncostatin M receptor increases response to substance ISO OSMR protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262 		JBrowse link
G Osr2 odd-skipped related transciption factor 2 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of OSR2 mRNA CTD PMID:20705681 NCBI chr 7:66,487,841...66,495,003
Ensembl chr 7:66,487,839...66,495,224 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide increases expression EXP Paclitaxel analog results in increased expression of OXT mRNA; Paclitaxel results in increased expression of OXT mRNA CTD PMID:15585946 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490 		JBrowse link
G P2rx4 purinergic receptor P2X 4 increases expression
multiple interactions		 EXP Paclitaxel results in increased expression of P2RX4 protein
1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased expression of P2RX4 protein]		 CTD PMID:30414958 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G Padi2 peptidyl arginine deiminase 2 decreases expression ISO Paclitaxel results in decreased expression of PADI2 protein CTD PMID:15907983 NCBI chr 5:153,209,053...153,251,632
Ensembl chr 5:153,209,053...153,251,632 		JBrowse link
G Papln papilin, proteoglycan-like sulfated glycoprotein multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in decreased expression of PAPLN mRNA CTD PMID:20705681 NCBI chr 6:103,398,166...103,432,199
Ensembl chr 6:103,398,838...103,432,206 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
affects response to substance
increases expression		 ISO Paclitaxel results in increased cleavage of PARP1 protein
[3,3'-diindolylmethane co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of PARP1 protein; [Luteolin co-treated with Paclitaxel] results in decreased expression of PARP1 protein; [norcantharidin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein; [piperine analog co-treated with Paclitaxel] results in increased cleavage of PARP1 protein; [Resveratrol co-treated with Paclitaxel] results in increased cleavage of PARP1 protein; [voacamine co-treated with Paclitaxel] results in increased cleavage of PARP1 protein; AKT1 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; alvocidib promotes the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; CD40LG protein inhibits the reaction [Paclitaxel promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; MAP2K4 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; MAP3K5 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; MAPK8 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; Paclitaxel promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; Paclitaxel promotes the reaction [norcantharidin results in increased expression of PARP1 protein modified form]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein]; TYMP inhibits the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; TYMP mutant form promotes the reaction [Paclitaxel results in increased cleavage of PARP1 protein]
PARP1 protein affects the susceptibility to Paclitaxel
Paclitaxel results in increased expression of PARP1 protein modified form
[rottlerin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein		 CTD PMID:10075725 PMID:10430095 PMID:10502406 PMID:11774260 PMID:14749477 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of PAWR mRNA CTD PMID:20705681 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pcca propionyl-CoA carboxylase subunit alpha decreases expression ISO Paclitaxel results in decreased expression of PCCA protein CTD PMID:15907983 NCBI chr15:99,627,955...99,969,555
Ensembl chr15:99,627,982...99,968,266 		JBrowse link
G Pccb propionyl-CoA carboxylase subunit beta increases expression EXP Paclitaxel results in increased expression of PCCB mRNA CTD PMID:15585946 NCBI chr 8:101,591,218...101,641,213
Ensembl chr 8:101,590,737...101,641,234 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
increases expression		 ISO [Imatinib Mesylate co-treated with Paclitaxel] results in decreased expression of PCNA protein
Paclitaxel results in decreased expression of PCNA protein
Paclitaxel results in increased expression of PCNA		 CTD PMID:9858906 PMID:15867366 PMID:36683349 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pcolce procollagen C-endopeptidase enhancer increases expression ISO Paclitaxel results in increased expression of PCOLCE mRNA CTD PMID:19682730 NCBI chr12:19,084,191...19,090,508
Ensembl chr12:19,084,210...19,090,508 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO [PDK1 protein binds to AKT1 protein] results in decreased susceptibility to [Paclitaxel co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]; [PDK1 protein binds to AKT1 protein] which results in decreased susceptibility to Paclitaxel CTD PMID:20361045 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases response to substance ISO PDPK1 protein results in decreased susceptibility to Paclitaxel CTD PMID:16782806 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO [Imatinib Mesylate co-treated with Paclitaxel] results in decreased expression of PECAM1 protein; zoledronic acid promotes the reaction [[Imatinib Mesylate co-treated with Paclitaxel] results in decreased expression of PECAM1 protein] CTD PMID:15867366 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO Paclitaxel results in increased expression of PERP mRNA CTD PMID:18058816 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression EXP Paclitaxel results in decreased expression of PHGDH protein CTD PMID:21118710 NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944 		JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha affects response to substance ISO PIK3C2A protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel increases response to substance ISO PKD2 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825 		JBrowse link
G Pklr pyruvate kinase L/R decreases expression ISO Paclitaxel results in decreased expression of PKLR mRNA CTD PMID:12929121 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870 		JBrowse link
G Pkm pyruvate kinase M1/2 affects response to substance ISO PKM protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pkp2 plakophilin 2 decreases response to substance ISO PKP2 protein results in decreased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730 		JBrowse link
G Pla2g2a phospholipase A2 group IIA increases expression EXP Paclitaxel results in increased expression of PLA2G2A mRNA CTD PMID:18754875 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Pla2g2d phospholipase A2, group IID increases expression EXP Paclitaxel results in increased expression of PLA2G2D mRNA CTD PMID:18754875 NCBI chr 5:151,016,010...151,022,531
Ensembl chr 5:151,018,870...151,022,525 		JBrowse link
G Plce1 phospholipase C, epsilon 1 decreases response to substance ISO PLCE1 protein results in decreased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438 		JBrowse link
G Plcl1 phospholipase C-like 1 increases expression EXP Paclitaxel analog results in increased expression of PLCL1 mRNA; Paclitaxel results in increased expression of PLCL1 mRNA CTD PMID:15585946 NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782 		JBrowse link
G Plin2 perilipin 2 multiple interactions ISO [FV-429 compound co-treated with Paclitaxel] inhibits the reaction [Oxygen deficiency results in increased expression of PLIN2 protein]; [Paclitaxel co-treated with FV-429 compound co-treated with Deferoxamine] promotes the reaction [Oxygen deficiency results in increased expression of PLIN2 protein]; [Paclitaxel co-treated with FV-429 compound] inhibits the reaction [Oxygen deficiency results in increased expression of PLIN2 mRNA]; [Paclitaxel co-treated with FV-429 compound] inhibits the reaction [Oxygen deficiency results in increased expression of PLIN2 protein] CTD PMID:34648812 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Plk1 polo-like kinase 1 multiple interactions ISO [pifithrin co-treated with Paclitaxel] results in increased expression of PLK1 protein CTD PMID:18516295 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Plk4 polo-like kinase 4 decreases expression ISO Paclitaxel results in decreased expression of PLK4 mRNA CTD PMID:15000894 NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942 		JBrowse link
G Plpp1 phospholipid phosphatase 1 decreases response to substance ISO PLPP1 protein results in decreased susceptibility to Paclitaxel CTD PMID:16734730 NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268 		JBrowse link
G Plpp2 phospholipid phosphatase 2 decreases expression ISO Paclitaxel results in decreased expression of PLPP2 mRNA CTD PMID:19682730 NCBI chr 7:10,175,918...10,184,032
Ensembl chr 7:10,175,948...10,184,071 		JBrowse link
G Pmp22 peripheral myelin protein 22 decreases response to substance ISO PMP22 mRNA results in decreased susceptibility to Paclitaxel CTD PMID:16322897 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Polk DNA polymerase kappa decreases expression ISO Paclitaxel results in decreased expression of POLK mRNA CTD PMID:15000894 NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313 		JBrowse link
G Por cytochrome p450 oxidoreductase increases response to substance ISO POR mRNA results in increased susceptibility to Paclitaxel CTD PMID:15239142 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Postn periostin decreases response to substance
increases expression		 ISO POSTN mRNA results in decreased susceptibility to Paclitaxel
Paclitaxel results in increased expression of POSTN mRNA		 CTD PMID:19682730 PMID:25199881 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO [Cisplatin co-treated with Paclitaxel] results in increased expression of POU5F1 mRNA; [Cisplatin co-treated with Paclitaxel] results in increased expression of POU5F1 protein CTD PMID:20705681 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Ppib peptidylprolyl isomerase B affects response to substance ISO PPIB protein affects the susceptibility to Paclitaxel CTD PMID:16217747 NCBI chr 8:66,603,877...66,609,734
Ensembl chr 8:66,603,861...66,630,428 		JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta affects response to substance</