CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: propane
Accession: CHEBI:32879
browse the term
Definition: An alkane that has formula C3H8.
Synonyms: related_synonym: CH3-CH2-CH3; E944; Formula=C3H8; InChI=1S/C3H8/c1-3-2/h3H2,1-2H3; InChIKey=ATUOYWHBWRKTHZ-UHFFFAOYSA-N; Propan; SMILES=CCC
xref: Beilstein:1730718; CAS:74-98-6; Gmelin:25044
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Abcb1b
ATP-binding cassette, sub-family B member 1B
increases expression
ISO
1-nitropropane results in increased expression of ABCB1B mRNA
CTD
PMID:17070881
NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315
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Acmsd
amino carboxymuconate semialdehyde decarboxylase
increases expression
ISO
1-nitropropane results in increased expression of ACMSD mRNA
CTD
PMID:17070881
NCBI chr 1:127,657,149...127,695,723
Ensembl chr 1:127,657,150...127,695,715
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Acsl3
acyl-CoA synthetase long-chain family member 3
decreases expression
ISO
1-nitropropane results in decreased expression of ACSL3 mRNA
CTD
PMID:17070881
NCBI chr 1:78,635,600...78,685,462
Ensembl chr 1:78,635,542...78,685,460
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Aen
apoptosis enhancing nuclease
increases expression
ISO
1-nitropropane results in increased expression of AEN mRNA
CTD
PMID:17070881
NCBI chr 7:78,545,675...78,560,957
Ensembl chr 7:78,545,602...78,560,957
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Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
increases expression
ISO
1-nitropropane results in increased expression of ALDH1A1 mRNA
CTD
PMID:17070881
NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
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Apoa2
apolipoprotein A-II
increases expression
ISO
1-nitropropane results in increased expression of APOA2 mRNA
CTD
PMID:17070881
NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948
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Apoa4
apolipoprotein A-IV
decreases expression
ISO
1-nitropropane results in decreased expression of APOA4 mRNA
CTD
PMID:17070881
NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757
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Apoc3
apolipoprotein C-III
increases expression
ISO
1-nitropropane results in increased expression of APOC3 mRNA
CTD
PMID:17070881
NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934
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Atp6v1d
ATPase, H+ transporting, lysosomal V1 subunit D
increases expression
ISO
1-nitropropane results in increased expression of ATP6V1D mRNA
CTD
PMID:17070881
NCBI chr12:78,889,756...78,908,810
Ensembl chr12:78,887,499...78,908,412
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Bax
BCL2-associated X protein
increases expression
ISO
1-nitropropane results in increased expression of BAX mRNA
CTD
PMID:17070881
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Btg2
BTG anti-proliferation factor 2
decreases expression
ISO
1-nitropropane results in decreased expression of BTG2 mRNA
CTD
PMID:17070881
NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858
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C7
complement component 7
decreases expression
ISO
1-nitropropane results in decreased expression of C7 mRNA
CTD
PMID:17070881
NCBI chr15:5,017,232...5,093,230
Ensembl chr15:5,018,244...5,093,222
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Cblc
Casitas B-lineage lymphoma c
decreases expression
ISO
1-nitropropane results in decreased expression of CBLC mRNA
CTD
PMID:17070881
NCBI chr 7:19,513,643...19,530,734
Ensembl chr 7:19,512,806...19,530,734
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Ccng1
cyclin G1
increases expression
ISO
1-nitropropane results in increased expression of CCNG1 mRNA
CTD
PMID:17070881
NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138
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Cd276
CD276 antigen
decreases expression
ISO
1-nitropropane results in decreased expression of CD276 mRNA
CTD
PMID:17070881
NCBI chr 9:58,431,581...58,463,437
Ensembl chr 9:58,431,581...58,462,720
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Cdkn1a
cyclin dependent kinase inhibitor 1A
decreases expression
ISO
1-nitropropane results in decreased expression of CDKN1A mRNA
CTD
PMID:17070881
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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Cpq
carboxypeptidase Q
decreases expression
ISO
1-nitropropane results in decreased expression of CPQ mRNA
CTD
PMID:17070881
NCBI chr15:33,083,275...33,594,698
Ensembl chr15:33,083,275...33,594,698
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Cryab
crystallin, alpha B
decreases expression
ISO
1-nitropropane results in decreased expression of CRYAB mRNA
CTD
PMID:17070881
NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936
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Ddah1
dimethylarginine dimethylaminohydrolase 1
decreases expression
ISO
1-nitropropane results in decreased expression of DDAH1 mRNA
CTD
PMID:17070881
NCBI chr 3:145,464,447...145,600,032
Ensembl chr 3:145,464,430...145,600,032
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Epcam
epithelial cell adhesion molecule
decreases expression
ISO
1-nitropropane results in decreased expression of EPCAM mRNA
CTD
PMID:17070881
NCBI chr17:87,943,407...87,958,555
Ensembl chr17:87,943,407...87,958,557
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Ephx1
epoxide hydrolase 1, microsomal
decreases expression
ISO
1-nitropropane results in decreased expression of EPHX1 mRNA
CTD
PMID:17070881
NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469
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Fas
Fas cell surface death receptor
increases expression
ISO
1-nitropropane results in increased expression of FAS mRNA
CTD
PMID:17070881
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
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Fhit
fragile histidine triad gene
increases expression
ISO
1-nitropropane results in increased expression of FHIT mRNA
CTD
PMID:17070881
NCBI chr14:11,307,718...12,919,681
Ensembl chr14:11,307,738...12,919,681
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Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
decreases expression
ISO
1-nitropropane results in decreased expression of GRIA3 mRNA
CTD
PMID:17070881
NCBI chr X:40,489,351...40,767,478
Ensembl chr X:40,489,731...40,767,478
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Gstm1
glutathione S-transferase, mu 1
decreases expression
ISO
1-nitropropane results in decreased expression of GSTM1 mRNA
CTD
PMID:17070881
NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
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Hsd17b6
hydroxysteroid (17-beta) dehydrogenase 6
increases expression
ISO
1-nitropropane results in increased expression of HSD17B6 mRNA
CTD
PMID:17070881
NCBI chr10:127,826,800...127,843,517
Ensembl chr10:127,826,805...127,843,480
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Il2ra
interleukin 2 receptor, alpha chain
decreases expression
ISO
1-nitropropane results in decreased expression of IL2RA mRNA
CTD
PMID:17070881
NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004
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Mgmt
O-6-methylguanine-DNA methyltransferase
increases expression
ISO
1-nitropropane results in increased expression of MGMT mRNA
CTD
PMID:17070881
NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995
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Nupr1
nuclear protein transcription regulator 1
increases expression
ISO
1-nitropropane results in increased expression of NUPR1 mRNA
CTD
PMID:17070881
NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033
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Phlda3
pleckstrin homology like domain, family A, member 3
decreases expression
ISO
1-nitropropane results in decreased expression of PHLDA3 mRNA
CTD
PMID:17070881
NCBI chr 1:135,693,823...135,696,872
Ensembl chr 1:135,693,857...135,696,874
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Rhobtb2
Rho-related BTB domain containing 2
increases expression
ISO
1-nitropropane results in increased expression of RHOBTB2 mRNA
CTD
PMID:17070881
NCBI chr14:70,022,439...70,062,296
Ensembl chr14:70,022,439...70,043,085
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Serpina7
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
decreases expression
ISO
1-nitropropane results in decreased expression of SERPINA7 mRNA
CTD
PMID:17070881
NCBI chr X:137,979,998...137,985,985
Ensembl chr X:137,980,006...137,985,985
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Slc16a10
solute carrier family 16 (monocarboxylic acid transporters), member 10
increases expression
ISO
1-nitropropane results in increased expression of SLC16A10 mRNA
CTD
PMID:17070881
NCBI chr10:39,909,528...40,018,262
Ensembl chr10:39,909,528...40,018,254
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Spink1
serine peptidase inhibitor, Kazal type 1
increases expression
ISO
1-nitropropane results in increased expression of SPINK1 mRNA
CTD
PMID:17070881
NCBI chr18:43,861,134...43,870,302
Ensembl chr18:43,861,147...43,870,622
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Sugct
succinyl-CoA glutarate-CoA transferase
decreases expression
ISO
1-nitropropane results in decreased expression of SUGCT mRNA
CTD
PMID:17070881
NCBI chr13:17,032,057...17,869,380
Ensembl chr13:17,032,057...17,870,138
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Sulf2
sulfatase 2
increases expression
ISO
1-nitropropane results in increased expression of SULF2 mRNA
CTD
PMID:17070881
NCBI chr 2:165,915,819...165,997,603
Ensembl chr 2:165,915,009...165,997,583
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Sult2a1
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
increases expression
ISO
1-nitropropane results in increased expression of SULT2A1 mRNA
CTD
PMID:17070881
NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334
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Zmat3
zinc finger matrin type 3
decreases expression
ISO
1-nitropropane results in decreased expression of ZMAT3 mRNA
CTD
PMID:17070881
NCBI chr 3:32,388,941...32,419,814
Ensembl chr 3:32,388,941...32,420,163
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Cd274
CD274 antigen
affects binding
ISO
daclatasvir binds to CD274 protein
CTD
PMID:39418845
NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495
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Ahr
aryl-hydrocarbon receptor
multiple interactions
ISO
fluvalinate analog promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD
PMID:25684042
NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
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Cdk2
cyclin dependent kinase 2
affects binding
ISO
fluvalinate binds to CDK2 protein
CTD
PMID:32278787
NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
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Erbb2
erb-b2 receptor tyrosine kinase 2
affects binding
ISO
fluvalinate binds to ERBB2 protein
CTD
PMID:32278787
NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542
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Fgfr2
fibroblast growth factor receptor 2
affects binding
ISO
fluvalinate binds to FGFR2 protein
CTD
PMID:32278787
NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079
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Mmp9
matrix metallopeptidase 9
affects binding
ISO
fluvalinate binds to MMP9 protein
CTD
PMID:32278787
NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
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Nqo1
NAD(P)H dehydrogenase, quinone 1
affects binding
ISO
fluvalinate binds to NQO1 protein
CTD
PMID:32278787
NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
fluvalinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
CTD
PMID:25257666
NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO EXP
fluvalinate binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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Ppard
peroxisome proliferator activator receptor delta
affects binding
ISO
fluvalinate binds to PPARD protein
CTD
PMID:32278787
NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448
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Rora
RAR-related orphan receptor alpha
affects binding
ISO
fluvalinate binds to RORA protein
CTD
PMID:32278787
NCBI chr 9:68,560,627...69,295,528
Ensembl chr 9:68,561,068...69,295,528
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Rorc
RAR-related orphan receptor gamma
affects binding
ISO
fluvalinate binds to RORC protein
CTD
PMID:32278787
NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583
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Abcg2
ATP binding cassette subfamily G member 2 (Junior blood group)
affects binding
ISO
ledipasvir binds to ABCG2 protein
CTD
PMID:33954893
NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
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Klrc1
killer cell lectin-like receptor subfamily C, member 1
decreases expression
ISO
ledipasvir co-treated with sofosbuvir decreases expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 6:129,642,978...129,659,815
Ensembl chr 6:129,642,978...129,655,936
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Ncr1
natural cytotoxicity triggering receptor 1
affects expression
ISO
ledipasvir co-treated sofosbuvir with affects expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 7:4,340,714...4,348,183
Ensembl chr 7:4,340,723...4,348,163
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Abcb11
ATP-binding cassette, sub-family B member 11
decreases activity multiple interactions
ISO
Ritonavir results in decreased activity of ABCB11 protein Ritonavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD
PMID:20829430 PMID:22646477 PMID:23956101 PMID:24014644 PMID:28437613
NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
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Abcb1a
ATP-binding cassette, sub-family B member 1A
multiple interactions
ISO
hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
CTD
PMID:15266218
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Abcb4
ATP-binding cassette, sub-family B member 4
decreases expression decreases activity
ISO
Ritonavir results in decreased expression of ABCB4 Ritonavir results in decreased activity of ABCB4 protein
CTD
PMID:26626330 PMID:28437613
NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
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Acss2
acyl-CoA synthetase short-chain family member 2
affects expression
ISO
Ritonavir affects the expression of ACSS2 mRNA
CTD
PMID:17719200
NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644
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Adipoq
adiponectin, C1Q and collagen domain containing
decreases expression multiple interactions
EXP ISO
Ritonavir results in decreased expression of ADIPOQ mRNA; Ritonavir results in decreased expression of ADIPOQ protein rosiglitazone inhibits the reaction [Ritonavir results in decreased secretion of ADIPOQ protein] diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of ADIPOQ protein]
CTD
PMID:15865214 PMID:17668557
NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
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Akt1
thymoma viral proto-oncogene 1
increases phosphorylation
EXP
Ritonavir results in increased phosphorylation of AKT1 protein
CTD
PMID:36198369
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
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Alb
albumin
affects binding
ISO
Ritonavir binds to ALB protein
CTD
PMID:15814459 PMID:16336266
NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
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Bak1
BCL2-antagonist/killer 1
increases expression
ISO
Ritonavir results in increased expression of BAK1 protein
CTD
PMID:19386116
NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
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Bcl2
B cell leukemia/lymphoma 2
decreases expression
ISO
Ritonavir results in decreased expression of BCL2 protein
CTD
PMID:19386116
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Bcl2l1
BCL2-like 1
decreases expression
ISO
Ritonavir results in decreased expression of BCL2L1 mRNA
CTD
PMID:16174765
NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
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Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
Ritonavir results in decreased expression of BIRC5 mRNA; Ritonavir results in decreased expression of BIRC5 protein
CTD
PMID:16174765 PMID:21270666
NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
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Casp1
caspase 1
decreases expression
ISO
Ritonavir results in decreased expression of CASP1 protein
CTD
PMID:10551732
NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
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Casp3
caspase 3
decreases activity
ISO
Ritonavir results in decreased activity of CASP3 protein
CTD
PMID:10551732
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Ccl2
C-C motif chemokine ligand 2
multiple interactions increases expression increases secretion decreases expression
ISO
diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of CCL2 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CCL2 protein] Ritonavir results in decreased expression of CCL2
CTD
PMID:17668557 PMID:20884875 PMID:26626330
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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Ccl20
C-C motif chemokine ligand 20
decreases expression
ISO
Ritonavir results in decreased expression of CCL20
CTD
PMID:26626330
NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888
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Ccl3
C-C motif chemokine ligand 3
decreases expression increases expression
ISO
Ritonavir results in decreased expression of CCL3 Ritonavir results in increased expression of CCL3 protein
CTD
PMID:17668557 PMID:26626330
NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181
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Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
Ritonavir results in decreased expression of CCL4
CTD
PMID:26626330
NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509
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Ccna2
cyclin A2
decreases expression
ISO
Ritonavir results in decreased expression of CCNA2 mRNA
CTD
PMID:19386116
NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
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Ccnb1
cyclin B1
decreases expression
ISO
Ritonavir results in decreased expression of CCNB1 mRNA
CTD
PMID:19386116
NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
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Ccnd1
cyclin D1
decreases expression
ISO
Ritonavir results in decreased expression of CCND1 protein
CTD
PMID:16551874 PMID:21270666
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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Ccnd2
cyclin D2
decreases expression
ISO
Ritonavir results in decreased expression of CCND2 mRNA
CTD
PMID:16174765 PMID:19386116
NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
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Ccne2
cyclin E2
decreases expression
ISO
Ritonavir results in decreased expression of CCNE2 mRNA
CTD
PMID:19386116
NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779
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Cdk2
cyclin dependent kinase 2
decreases expression
ISO
Ritonavir results in decreased expression of CDK2 mRNA; Ritonavir results in decreased expression of CDK2 protein
CTD
PMID:16551874 PMID:19386116
NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
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Cdk3
cyclin dependent kinase 3
increases expression
ISO
Ritonavir results in increased expression of CDK3 mRNA
CTD
PMID:19386116
NCBI chr11:116,106,828...116,111,113
Ensembl chr11:116,106,829...116,111,113
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Cdk4
cyclin dependent kinase 4
decreases expression
ISO
Ritonavir results in decreased expression of CDK4 mRNA; Ritonavir results in decreased expression of CDK4 protein
CTD
PMID:16551874 PMID:19386116
NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
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Cdk5
cyclin dependent kinase 5
decreases expression
ISO
Ritonavir results in decreased expression of CDK5 mRNA
CTD
PMID:19386116
NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528
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Cdk6
cyclin dependent kinase 6
decreases expression
ISO
Ritonavir results in decreased expression of CDK6 mRNA; Ritonavir results in decreased expression of CDK6 protein
CTD
PMID:16551874 PMID:19386116
NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008
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Cdkn1a
cyclin dependent kinase inhibitor 1A
multiple interactions increases expression
ISO
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of CDKN1A protein] Ritonavir results in increased expression of CDKN1A mRNA; Ritonavir results in increased expression of CDKN1A protein
CTD
PMID:19386116 PMID:20884875
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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Cdkn1b
cyclin dependent kinase inhibitor 1B
increases expression
ISO
Ritonavir results in increased expression of CDKN1B mRNA
CTD
PMID:19386116
NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
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Cdkn2b
cyclin dependent kinase inhibitor 2B
increases expression
ISO
Ritonavir results in increased expression of CDKN2B mRNA
CTD
PMID:19386116
NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276
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Cebpa
CCAAT/enhancer binding protein alpha
multiple interactions
EXP
Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein]
CTD
PMID:11101056
NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
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Ciita
class II transactivator
increases expression
ISO
Ritonavir results in increased expression of CIITA
CTD
PMID:26626330
NCBI chr16:10,297,877...10,348,928
Ensembl chr16:10,297,923...10,346,282
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Crot
carnitine O-octanoyltransferase
decreases expression
ISO
Ritonavir results in decreased expression of CROT mRNA
CTD
PMID:17719200
NCBI chr 5:9,016,033...9,047,926
Ensembl chr 5:9,016,033...9,047,324
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Cxcl1
C-X-C motif chemokine ligand 1
decreases expression
ISO
Ritonavir results in decreased expression of CXCL1
CTD
PMID:26626330
NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974
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Cxcl10
C-X-C motif chemokine ligand 10
decreases expression
ISO
Ritonavir results in decreased expression of CXCL10
CTD
PMID:26626330
NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
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Cxcl12
C-X-C motif chemokine ligand 12
decreases expression
ISO
Ritonavir results in decreased expression of CXCL12
CTD
PMID:26626330
NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
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Cxcl15
C-X-C motif chemokine ligand 15
multiple interactions decreases expression increases secretion
ISO
Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CXCL8 protein] Ritonavir results in decreased expression of CXCL8
CTD
PMID:20884875 PMID:26626330
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Cxcl2
C-X-C motif chemokine ligand 2
decreases expression
ISO
Ritonavir results in decreased expression of CXCL2
CTD
PMID:26626330
NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
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Cxcl3
C-X-C motif chemokine ligand 3
decreases expression
ISO
Ritonavir results in decreased expression of CXCL1
CTD
PMID:26626330
NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459
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Cxcl5
C-X-C motif chemokine ligand 5
decreases expression
ISO
Ritonavir results in decreased expression of CXCL6
CTD
PMID:26626330
NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483
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Cyb5r3
cytochrome b5 reductase 3
affects expression
ISO
Ritonavir affects the expression of CYB5R3 mRNA
CTD
PMID:17719200
NCBI chr15:83,037,696...83,060,641
Ensembl chr15:83,037,695...83,056,793
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression decreases activity
ISO
Ritonavir results in increased expression of CYP1A1 mRNA Ritonavir results in decreased activity of CYP1A1 protein
CTD
PMID:11918509 PMID:33814510
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression decreases expression
ISO
Ritonavir results in increased expression of CYP1A2 mRNA Ritonavir results in decreased expression of CYP1A2 mRNA
CTD
PMID:11918509 PMID:17719200
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Ritonavir results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
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Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
increases activity increases expression
ISO
Ritonavir results in increased activity of CYP2B6 protein Ritonavir results in increased expression of CYP2B6 protein
CTD
PMID:14977870 PMID:26626330
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
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Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
decreases activity
ISO
Ritonavir results in decreased activity of CYP2C8 protein
CTD
PMID:15601807
NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
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Cyp2c38
cytochrome P450, family 2, subfamily c, polypeptide 38
increases expression
ISO
Ritonavir results in increased expression of CYP2C19 mRNA
CTD
PMID:11918509
NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
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Cyp2c65
cytochrome P450, family 2, subfamily c, polypeptide 65
increases activity increases expression
ISO
Ritonavir results in increased activity of CYP2C9 protein Ritonavir results in increased expression of CYP2C9 mRNA
CTD
PMID:11918509 PMID:19202563
NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
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Cyp2d22
cytochrome P450, family 2, subfamily d, polypeptide 22
affects metabolic processing
ISO
CYP2D6 protein affects the metabolism of Ritonavir
CTD
PMID:15286053
NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
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Cyp3a13
cytochrome P450, family 3, subfamily a, polypeptide 13
decreases activity
ISO
Ritonavir results in decreased activity of CYP3A5 protein
CTD
PMID:15523003
NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
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Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
affects expression decreases expression
ISO
Ritonavir affects the expression of CYP4B1 mRNA Ritonavir results in decreased expression of CYP4B1 mRNA
CTD
PMID:17719200
NCBI chr 4:115,481,895...115,504,918
Ensembl chr 4:115,481,922...115,504,920
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Cyp51
cytochrome P450, family 51
increases expression
ISO
Ritonavir results in increased expression of CYP51 mRNA
CTD
PMID:17719200
NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746
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Cyp7a1
cytochrome P450, family 7, subfamily a, polypeptide 1
decreases expression
ISO
Ritonavir results in decreased expression of CYP7A1 mRNA
CTD
PMID:17719200 PMID:26626330
NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
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Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
decreases expression
ISO
Ritonavir results in decreased expression of CYP8B1 Ritonavir results in decreased expression of CYP8B1 mRNA
CTD
PMID:17719200 PMID:26626330
NCBI chr 9:121,743,422...121,745,371
Ensembl chr 9:121,743,422...121,745,371
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Dhcr7
7-dehydrocholesterol reductase
affects expression
ISO
Ritonavir affects the expression of DHCR7 mRNA
CTD
PMID:17719200
NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147
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E2f1
E2F transcription factor 1
decreases expression
ISO
Ritonavir results in decreased expression of E2F1 mRNA; Ritonavir results in decreased expression of E2F1 protein
CTD
PMID:19386116
NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
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E2f2
E2F transcription factor 2
decreases expression
ISO
Ritonavir results in decreased expression of E2F2 mRNA
CTD
PMID:19386116
NCBI chr 4:135,899,585...135,923,368
Ensembl chr 4:135,899,705...135,923,368
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E2f3
E2F transcription factor 3
decreases expression
ISO
Ritonavir results in decreased expression of E2F3 mRNA
CTD
PMID:19386116
NCBI chr13:30,090,558...30,171,172
Ensembl chr13:30,090,558...30,170,046
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Ehhadh
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
affects expression
ISO
Ritonavir affects the expression of EHHADH mRNA
CTD
PMID:17719200
NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557
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Esr1
estrogen receptor 1 (alpha)
decreases expression
ISO
Ritonavir results in decreased expression of ESR1 protein
CTD
PMID:16551874
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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Fasl
Fas ligand
decreases expression
ISO
Ritonavir results in decreased expression of FASLG protein
CTD
PMID:10551732
NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
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Fasn
fatty acid synthase
affects expression
ISO
Ritonavir affects the expression of FASN mRNA
CTD
PMID:17719200
NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
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Fgf15
fibroblast growth factor 15
increases expression
ISO
Ritonavir results in increased expression of FGF19 mRNA
CTD
PMID:26626330
NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690
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Fos
FBJ osteosarcoma oncogene
increases expression
ISO
Ritonavir results in increased expression of FOS protein
CTD
PMID:15504750
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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Glb1
galactosidase, beta 1
multiple interactions increases activity
ISO
Acetylcysteine inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; FTI 277 inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]
CTD
PMID:20884875
NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966
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Gpd1
glycerol-3-phosphate dehydrogenase 1 (soluble)
multiple interactions
EXP
Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein]
CTD
PMID:11101056
NCBI chr15:99,615,468...99,622,895
Ensembl chr15:99,615,396...99,622,886
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Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]; NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [Atazanavir Sulfate results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [Lopinavir results in increased expression of HMOX1 mRNA]; Rotenone inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; tricarbonyldichlororuthenium (II) dimer promotes the reaction [Ritonavir results in increased expression of HMOX1 protein] Ritonavir results in increased expression of HMOX1 mRNA; Ritonavir results in increased expression of HMOX1 protein
CTD
PMID:15504750 PMID:26968795
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
affects response to substance
EXP
HSP90AA1 protein affects the susceptibility to Ritonavir
CTD
PMID:16551874
NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162
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Hsph1
heat shock 105kDa/110kDa protein 1
increases expression
ISO
Ritonavir results in increased expression of HSPH1 protein
CTD
PMID:26626330
NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841
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Icam1
intercellular adhesion molecule 1
increases expression multiple interactions
ISO
Ritonavir results in increased expression of ICAM1 protein HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]
CTD
PMID:26968795
NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
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Ifng
interferon gamma
multiple interactions
ISO
Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein]
CTD
PMID:10551732
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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Il6
interleukin 6
multiple interactions increases expression increases secretion
ISO EXP
diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of IL6 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of IL6 protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] rosiglitazone inhibits the reaction [Ritonavir results in increased expression of IL6 mRNA] Ritonavir results in increased expression of IL6 mRNA; Ritonavir results in increased expression of IL6 protein
CTD
PMID:15388451 PMID:15865214 PMID:17668557 PMID:20884875
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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Il7
interleukin 7
decreases expression
ISO
Ritonavir results in decreased expression of IL7
CTD
PMID:26626330
NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820
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Ins1
insulin I
multiple interactions
EXP
Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein]; Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein]; Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein]; Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein]
CTD
PMID:11101056
NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
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Jun
jun proto-oncogene
increases expression
ISO
Ritonavir results in increased expression of JUN protein
CTD
PMID:15504750
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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Lep
leptin
multiple interactions decreases expression
ISO
diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein]
CTD
PMID:17668557
NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
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Lif
leukemia inhibitory factor
decreases expression
ISO
Ritonavir results in decreased expression of LIF
CTD
PMID:26626330
NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514
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Lmna
lamin A
increases expression increases farnesylation
ISO
Ritonavir results in increased expression of LMNA protein Ritonavir results in increased farnesylation of LMNA protein alternative form
CTD
PMID:18230615 PMID:20884875
NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
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Lpl
lipoprotein lipase
affects expression
EXP
Ritonavir affects the expression of LPL mRNA
CTD
PMID:11741158
NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100
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Myc
myelocytomatosis oncogene
decreases expression
ISO
Ritonavir results in decreased expression of MYC mRNA
CTD
PMID:16174765
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
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Nfe2l2
nuclear factor, erythroid derived 2, like 2
increases expression multiple interactions
ISO
Ritonavir results in increased expression of NFE2L2 protein NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]
CTD
PMID:26968795
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
decreases activity
ISO
Ritonavir results in decreased activity of NFKB1 protein
CTD
PMID:16174765
NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
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Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
decreases phosphorylation
ISO
Ritonavir results in decreased phosphorylation of NFKBIA protein
CTD
PMID:16174765
NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
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Nlrc5
NLR family, CARD domain containing 5
decreases expression
ISO
Ritonavir results in decreased expression of NLRC5
CTD
PMID:26626330
NCBI chr 8:95,160,963...95,253,900
Ensembl chr 8:95,160,984...95,253,900
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Nos3
nitric oxide synthase 3, endothelial cell
multiple interactions decreases expression
ISO
Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA]
CTD
PMID:22037733
NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
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Notch4
notch 4
decreases expression multiple interactions
ISO
Ritonavir results in decreased expression of NOTCH4 protein [Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]
CTD
PMID:20722969
NCBI chr17:34,783,257...34,807,517
Ensembl chr17:34,783,242...34,807,477
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Nr1h3
nuclear receptor subfamily 1, group H, member 3
increases expression
ISO
Ritonavir increases expression of NR1H3 mRNA in macrophages
RGD
PMID:18849545
RGD:401842387
NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
increases expression
ISO
Ritonavir results in increased expression of NR1H4 mRNA
CTD
PMID:26626330
NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions increases activity
ISO
Ritonavir binds to and results in increased activity of NR1I2 protein Ritonavir results in increased activity of NR1I2 protein
CTD
PMID:14977870 PMID:15849716 PMID:27732639
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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Parp1
poly (ADP-ribose) polymerase family, member 1
increases cleavage
ISO
Ritonavir results in increased cleavage of PARP1 protein
CTD
PMID:19386116 PMID:21270666
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
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Pon1
paraoxonase 1
decreases activity
ISO
Ritonavir results in decreased activity of PON1 protein
CTD
PMID:27378623
NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946
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Pparg
peroxisome proliferator activated receptor gamma
multiple interactions increases expression
EXP ISO
Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein] Ritonavir results in increased expression of PPARG mRNA
CTD
PMID:11101056 PMID:17879945
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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Prkca
protein kinase C, alpha
multiple interactions increases activity increases expression
EXP
Ritonavir binds to and affects the localization of PRKCA protein Ritonavir results in increased activity of PRKCA protein Ritonavir results in increased expression of PRKCA protein
CTD
PMID:22020176
NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754
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Psma1
proteasome subunit alpha 1
affects expression
ISO
Ritonavir affects the expression of PSMA1 mRNA
CTD
PMID:17719200
NCBI chr 7:113,863,785...113,875,351
Ensembl chr 7:113,863,841...113,875,353
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Psmb3
proteasome (prosome, macropain) subunit, beta type 3
affects expression
ISO
Ritonavir affects the expression of PSMB3 mRNA
CTD
PMID:17719200
NCBI chr11:97,594,260...97,604,326
Ensembl chr11:97,594,225...97,604,326
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Psmb5
proteasome (prosome, macropain) subunit, beta type 5
increases expression
ISO
Ritonavir results in increased expression of PSMB5 mRNA
CTD
PMID:20213465
NCBI chr14:54,851,577...54,855,452
Ensembl chr14:54,851,576...54,855,479
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Rb1
RB transcriptional corepressor 1
decreases phosphorylation increases expression
ISO
Ritonavir results in decreased phosphorylation of RB1 protein Ritonavir results in increased expression of RB1 mRNA
CTD
PMID:16551874 PMID:19386116 PMID:21270666
NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
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Rbl1
RB transcriptional corepressor like 1
increases expression
ISO
Ritonavir results in increased expression of RBL1 mRNA
CTD
PMID:19386116
NCBI chr 2:156,987,813...157,046,454
Ensembl chr 2:156,987,813...157,046,454
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Rbl2
RB transcriptional corepressor like 2
decreases expression
ISO
Ritonavir results in decreased expression of RBL2 mRNA
CTD
PMID:19386116
NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472
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Rel
reticuloendotheliosis oncogene
decreases activity
ISO
Ritonavir results in decreased activity of REL protein
CTD
PMID:16174765
NCBI chr11:23,686,847...23,720,969
Ensembl chr11:23,686,847...23,720,970
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Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
decreases activity
ISO
Ritonavir results in decreased activity of RELA protein
CTD
PMID:16174765
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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Scarb1
scavenger receptor class B, member 1
multiple interactions increases expression
ISO
Estradiol inhibits the reaction [Ritonavir results in increased expression of SCARB1 protein] Ritonavir results in increased expression of SCARB1 mRNA
CTD
PMID:17879945
NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
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Scp2
sterol carrier protein 2, liver
decreases expression
ISO
Ritonavir results in decreased expression of SCP2
CTD
PMID:26626330
NCBI chr 4:107,901,027...108,002,168
Ensembl chr 4:107,901,036...108,002,195
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Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
decreases expression
ISO
Ritonavir results in decreased expression of SLC10A1
CTD
PMID:26626330
NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479
G
Slc51a
solute carrier family 51, alpha subunit
decreases expression
ISO
Ritonavir results in decreased expression of SLC51A
CTD
PMID:26626330
NCBI chr16:32,294,396...32,306,697
Ensembl chr16:32,293,322...32,306,697
G
Slco4c1
solute carrier organic anion transporter family, member 4C1
multiple interactions
ISO
Ritonavir inhibits the reaction [SLCO4C1 protein affects the transport of traumatic acid]
CTD
PMID:39041788
NCBI chr 1:96,744,918...96,800,027
Ensembl chr 1:96,743,995...96,799,896
G
Src
Rous sarcoma oncogene
decreases phosphorylation
ISO
Ritonavir results in decreased phosphorylation of SRC protein
CTD
PMID:21270666
NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
G
Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
EXP
Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein]
CTD
PMID:11101056
NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
G
Stat3
signal transducer and activator of transcription 3
decreases phosphorylation
ISO
Ritonavir results in decreased phosphorylation of STAT3 protein
CTD
PMID:21270666
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
G
Tjp1
tight junction protein 1
decreases expression multiple interactions
ISO
Ritonavir results in decreased expression of TJP1 protein [Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]
CTD
PMID:20722969
NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
G
Tnf
tumor necrosis factor
decreases secretion multiple interactions increases expression
ISO EXP
Ritonavir results in decreased secretion of TNF protein rosiglitazone inhibits the reaction [Ritonavir results in increased expression of TNF mRNA] Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Ritonavir results in increased expression of TNF mRNA; Ritonavir results in increased expression of TNF protein
CTD
PMID:10551732 PMID:15388451 PMID:15865214
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
G
Trp53
transformation related protein 53
multiple interactions increases expression
ISO
FTI 277 inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]
CTD
PMID:19386116 PMID:20884875
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
G
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
affects expression
ISO
Ritonavir affects the expression of UGT1A1 mRNA
CTD
PMID:15849716
NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
G
Zmpste24
zinc metallopeptidase, STE24
decreases activity
ISO
Ritonavir results in decreased activity of ZMPSTE24 protein
CTD
PMID:18230615
NCBI chr 4:120,916,434...120,955,452
Ensembl chr 4:120,916,434...120,955,438
G
App
amyloid beta precursor protein
increases abundance multiple interactions
ISO EXP
APP protein mutant form results in increased abundance of Valine [APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Valine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Valine] PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of Valine]
CTD
PMID:39172838
NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
G
Egf
epidermal growth factor
multiple interactions
ISO
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine]
CTD
PMID:22689575
NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
G
Mapt
microtubule-associated protein tau
increases abundance multiple interactions
ISO
MAPT protein mutant form results in increased abundance of Valine PF-06840003 inhibits the reaction [MAPT protein mutant form results in increased abundance of Valine]
CTD
PMID:39172838
NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
G
Psen1
presenilin 1
multiple interactions
EXP
[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Valine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Valine]
CTD
PMID:39172838
NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973
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