secondary amine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	secondary amine	go back to main search page
Accession:	CHEBI:32863	browse the term
Definition:	A compound formally derived from ammonia by replacing two hydrogen atoms by hydrocarbyl groups.
Synonyms:	exact_synonym:	secondary amines
	related_synonym:	Formula=HNR2; R2NH; SMILES=[H]N([])[]; sekundaeres Amin
	alt_id:	CHEBI:26618; CHEBI:9078
	xref:	KEGG:C02324
	cyclic_relationship:	is_conjugate_base_of CHEBI:137419

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Rat (1847) Mouse (1846) Human (1833) Chinchilla (0) Bonobo (0) Dog (4) Squirrel (0) Pig (4) Green Monkey (0) Naked Mole-rat (0) All
Genes (1847)

bisoprolol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases transport
multiple interactions

ABCB1 protein results in increased transport of Bisoprolol
Bisoprolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Bisoprolol]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

adrenoceptor beta 1

decreases activity
increases expression
multiple interactions
affects binding

Bisoprolol results in decreased activity of ADRB1 protein
Bisoprolol results in increased expression of ADRB1 mRNA
[Bisoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; Bisoprolol binds to and results in decreased activity of ADRB1 protein; Bisoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Bisoprolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]
Bisoprolol binds to ADRB1 protein

PMID:1389726 PMID:2897299 PMID:10372227 PMID:11562432 PMID:12535855 More...

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

multiple interactions
increases expression

[Bisoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [Bisoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Bisoprolol binds to and results in decreased activity of ADRB2 protein; Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]
Bisoprolol results in increased expression of ADRB2 mRNA

PMID:14730417 PMID:17925438 PMID:20668454

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

adrenoceptor beta 3

multiple interactions

Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB3 protein]

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

C-C motif chemokine ligand 2

decreases expression

Bisoprolol results in decreased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

GNAS complex locus

increases expression

Bisoprolol results in increased expression of GNAS mRNA

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

interleukin 10

increases expression

Bisoprolol results in increased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

decreases expression

Bisoprolol results in decreased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

decreases expression

Bisoprolol results in decreased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 2

multiple interactions

Bisoprolol inhibits the reaction [Terbutaline results in increased expression of INS protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

protein kinase C, alpha

decreases expression

Bisoprolol results in decreased expression of PRKCA protein

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, delta

decreases expression

Bisoprolol results in decreased expression of PRKCD protein

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

solute carrier family 22 member 1

multiple interactions

Bisoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

multiple interactions

Bisoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

tumor necrosis factor

decreases expression

Bisoprolol results in decreased expression of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

brimonidine tartrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 2A

multiple interactions

Brimonidine Tartrate inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]; Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]]

PMID:8397342 PMID:10742289 PMID:12208771 PMID:12598592

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

angiotensinogen

multiple interactions

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased activity of RHOA protein]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

CF transmembrane conductance regulator

multiple interactions

Brimonidine Tartrate inhibits the reaction [CFTR protein affects the transport of Chlorides]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

cAMP responsive element binding protein 1

increases phosphorylation

Brimonidine Tartrate results in increased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

protein kinase C, alpha

affects localization
multiple interactions

Brimonidine Tartrate affects the localization of PRKCA protein
Nitric Oxide deficiency promotes the reaction [Brimonidine Tartrate affects the localization of PRKCA protein]

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, delta

affects localization
multiple interactions

Brimonidine Tartrate affects the localization of PRKCD protein
Nitric Oxide deficiency inhibits the reaction [Brimonidine Tartrate affects the localization of PRKCD protein]

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

ras homolog family member A

multiple interactions

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased activity of RHOA protein]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

solute carrier family 22 member 2

multiple interactions

Brimonidine Tartrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

diethylamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

histamine receptor H3

multiple interactions

diethylamine binds to and results in decreased activity of HRH3 protein

NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642

G

interferon gamma

multiple interactions

[diethylamine co-treated with Sodium Dodecyl Sulfate] results in increased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 18

increases activity

diethylamine results in increased activity of IL18 protein

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

increases activity

diethylamine results in increased activity of IL1A protein

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 4

multiple interactions

[diethylamine co-treated with Sodium Dodecyl Sulfate] results in increased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

dimethylamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

DEK proto-oncogene

increases secretion

DEK protein results in increased secretion of dimethylamine

NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808

G

histamine receptor H3

multiple interactions

dimethylamine binds to and results in decreased activity of HRH3 protein

NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642

dobutamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

Dobutamine results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

adenylate cyclase 6

affects response to substance

ADCY6 protein affects the susceptibility to Dobutamine

NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754

G

adrenoceptor alpha 2A

multiple interactions

Dobutamine binds to and results in increased activity of ADRA2A protein

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

adrenoceptor beta 1

affects response to substance
multiple interactions

ADRB1 gene affects the susceptibility to Dobutamine; ADRB1 gene polymorphism affects the susceptibility to Dobutamine; ADRB1 protein polymorphism affects the susceptibility to Dobutamine
[Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 mRNA; [Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 protein; Dobutamine binds to and results in increased activity of ADRB1 protein; Dobutamine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Oxygen deficiency results in increased susceptibility to [Dobutamine binds to and results in increased activity of ADRB1 protein]
ADRB1 gene polymorphism affects the susceptibility to [Dobutamine co-treated with Metoprolol]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Dobutamine binds to and results in increased activity of ADRB1 protein; Dobutamine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]

PMID:8096834 PMID:10192281 PMID:11753577 PMID:14502278 PMID:15564877 More...

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

affects response to substance

ADRB2 gene polymorphism affects the susceptibility to Dobutamine

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

adrenoceptor beta 3

multiple interactions

[Dobutamine co-treated with ICI 118551] results in increased expression of ADRB3 mRNA; [Dobutamine co-treated with ICI 118551] results in increased expression of ADRB3 protein

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

alpha-2-HS-glycoprotein

affects response to substance

AHSG protein affects the susceptibility to Dobutamine

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

AKT serine/threonine kinase 1

affects response to substance
multiple interactions

AKT1 protein affects the susceptibility to Dobutamine
Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein]

PMID:16094411 PMID:16339297

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

multiple interactions

Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein]

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

AKT serine/threonine kinase 3

multiple interactions

Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein]

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

arrestin, beta 1

multiple interactions

ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

arrestin, beta 2

multiple interactions

ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

BCL2 associated X, apoptosis regulator

increases expression

Dobutamine results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Dobutamine results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2 interacting protein 1

increases expression

Dobutamine results in increased expression of BNIP1 protein

NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157

G

C-C motif chemokine ligand 2

multiple interactions

Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

clusterin

increases expression

Dobutamine results in increased expression of CLU protein

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

catechol-O-methyltransferase

increases methylation
increases expression

COMT protein results in increased methylation of Dobutamine
Dobutamine results in increased expression of COMT mRNA

PMID:11160877 PMID:12423672

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

carnitine palmitoyltransferase 1A

increases expression

Dobutamine results in increased expression of CPT1A mRNA; Dobutamine results in increased expression of CPT1A protein

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cAMP responsive element modulator

affects response to substance

CREM protein affects the susceptibility to Dobutamine

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

cardiotrophin 1

affects response to substance

CTF1 protein affects the susceptibility to Dobutamine

NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335

G

C-X-C motif chemokine ligand 2

multiple interactions

Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

dopamine beta-hydroxylase

affects response to substance

DBH protein affects the susceptibility to Dobutamine

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

G

dystrophin

increases response to substance

DMD gene mutant form results in increased susceptibility to Dobutamine

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

G

epidermal growth factor receptor

decreases response to substance
multiple interactions

EGFR gene mutant form results in decreased susceptibility to Dobutamine
AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]

PMID:18599591 PMID:18787115

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

estrogen receptor 1

multiple interactions

Dobutamine binds to and results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

coagulation factor III, tissue factor

increases expression

Dobutamine results in increased expression of F3 protein

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fibroblast growth factor 2

affects response to substance

FGF2 protein affects the susceptibility to Dobutamine

PMID:10491406 PMID:14583313

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]; Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glucose-6-phosphate dehydrogenase

increases activity

Dobutamine results in increased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth hormone 1

multiple interactions

GH1 protein promotes the reaction [Dobutamine results in increased metabolism of Lipids]

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

glycerol kinase

increases activity

Dobutamine results in increased activity of GK protein

NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631

G

GNAS complex locus

increases response to substance

GNAS gene SNP results in increased susceptibility to Dobutamine

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

glycogen synthase kinase 3 beta

affects response to substance

GSK3B gene mutant form affects the susceptibility to Dobutamine

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

heparin-binding EGF-like growth factor

multiple interactions

HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

heme oxygenase 1

multiple interactions
increases expression

esmolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]; Metoprolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 mRNA]; Metoprolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased expression of HMOX1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]
Dobutamine results in increased expression of HMOX1 mRNA; Dobutamine results in increased expression of HMOX1 protein

PMID:15179140 PMID:16627864

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

insulin-like growth factor 1

increases response to substance

IGF1 protein results in increased susceptibility to Dobutamine

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 10

multiple interactions

Dobutamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL10 protein]
Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]

PMID:11605937 PMID:15502056

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

increases expression
decreases expression

Dobutamine results in increased expression of IL1B mRNA
Dobutamine results in decreased expression of IL1B mRNA

PMID:9387890 PMID:32816093

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression
decreases expression
multiple interactions

Dobutamine results in increased expression of IL6 protein
Dobutamine results in decreased expression of IL6 mRNA
Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

PMID:11605937 PMID:12423672 PMID:16286589

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit beta 1

affects response to substance

ITGB1 protein affects the susceptibility to Dobutamine

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]; Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]; Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Dobutamine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium inwardly-rectifying channel, subfamily J, member 11

multiple interactions
affects response to substance

KCNJ11 protein affects the reaction [[Manganese co-treated with Dobutamine] results in increased abundance of Calcium]
KCNJ11 protein affects the susceptibility to Dobutamine

NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082

G

kallikrein 1

affects response to substance

KLK1 protein affects the susceptibility to Dobutamine

NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754

G

leptin

decreases secretion
decreases expression

Dobutamine results in decreased secretion of LEP protein
Dobutamine results in decreased expression of LEP mRNA; Dobutamine results in decreased expression of LEP protein

PMID:9002984 PMID:11022189

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

affects response to substance

LEPR protein affects the susceptibility to Dobutamine

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

[Dobutamine co-treated with ICI 118551] results in increased activity of MAPK1 protein
AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]
Dobutamine results in increased phosphorylation of MAPK1 protein

PMID:16760913 PMID:18787115 PMID:19719783

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

[Dobutamine co-treated with ICI 118551] results in increased activity of MAPK3 protein
AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]
Dobutamine results in increased phosphorylation of MAPK3 protein

PMID:16760913 PMID:18787115 PMID:19719783

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 9

multiple interactions

[Dobutamine co-treated with ICI 118551] results in increased activity of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

myoglobin

affects response to substance

MB protein affects the susceptibility to Dobutamine

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

NFKB inhibitor alpha

multiple interactions

Dobutamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 1

affects response to substance

NOS1 protein affects the susceptibility to Dobutamine

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

affects response to substance

NOS2 protein affects the susceptibility to Dobutamine

PMID:9396439 PMID:11489778

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 1, group H, member 4

increases activity

Dobutamine results in increased activity of NR1H4 protein

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

phosphoglycerate dehydrogenase

increases expression

Dobutamine results in increased expression of PHGDH mRNA

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

phospholamban

affects response to substance

PLN protein affects the susceptibility to Dobutamine

NCBI chr20:32,629,537...32,639,559

G

protein phosphatase 2 catalytic subunit alpha

affects response to substance

PPP2CA protein affects the susceptibility to Dobutamine

NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862

G

protein kinase cAMP-activated catalytic subunit alpha

multiple interactions

Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

G

protein kinase C, epsilon

affects response to substance

PRKCE protein affects the susceptibility to Dobutamine

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

PROP paired-like homeobox 1

decreases response to substance

PROP1 gene mutant form results in decreased susceptibility to Dobutamine

NCBI chr10:35,271,959...35,274,434
Ensembl chr10:35,271,973...35,274,434

G

prostaglandin-endoperoxide synthase 2

decreases expression

Dobutamine results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

renin

multiple interactions
increases expression
increases secretion
increases activity

Cycloheximide inhibits the reaction [Dobutamine results in increased secretion of REN protein]; Dactinomycin inhibits the reaction [Dobutamine results in increased secretion of REN protein]
Dobutamine results in increased expression of REN mRNA
Dobutamine results in increased activity of REN protein

PMID:9203624 PMID:9209250

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

S100 calcium binding protein A1

increases response to substance

S100A1 gene mutant form results in increased susceptibility to Dobutamine

NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544

G

sodium channel epithelial 1 subunit gamma

increases expression

Dobutamine results in increased expression of SCNN1G mRNA

NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816

G

sarcoglycan, delta

affects response to substance

SGCD affects the susceptibility to Dobutamine

NCBI chr10:31,346,480...32,328,364
Ensembl chr10:31,280,511...31,724,840

G

spectrin, alpha, non-erythrocytic 1

increases degradation

Dobutamine deficiency results in increased degradation of SPTAN1 protein

NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046

G

tachykinin, precursor 1

multiple interactions

Dobutamine promotes the reaction [TAC1 protein binds to and results in increased activity of TACR1 protein]

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

tachykinin receptor 1

multiple interactions

Dobutamine promotes the reaction [TAC1 protein binds to and results in increased activity of TACR1 protein]

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

G

transforming growth factor, beta 1

increases expression

Dobutamine results in increased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

increases expression

Dobutamine results in increased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

tumor necrosis factor

decreases expression
decreases secretion

Dobutamine results in decreased expression of TNF mRNA
Dobutamine results in decreased secretion of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 6

decreases expression

Dobutamine results in decreased expression of TNFAIP6 mRNA

NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649

G

upstream transcription factor 1

multiple interactions

USF1 gene polymorphism promotes the reaction [Dobutamine results in increased metabolism of Lipids]; USF1 protein affects the reaction [Dobutamine results in increased metabolism of Lipids]

NCBI chr13:83,845,230...83,854,875
Ensembl chr13:83,822,035...83,854,885

G

vascular endothelial growth factor A

affects response to substance

VEGFA protein affects the susceptibility to Dobutamine

PMID:11599061 PMID:14583313 PMID:19237429

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

maleimide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor protein p53

multiple interactions

maleimide analog binds to and results in increased activity of TP53 protein mutant form

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

methamphetamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aralkylamine N-acetyltransferase

decreases expression
multiple interactions

Methamphetamine results in decreased expression of AANAT mRNA
Lithium inhibits the reaction [Methamphetamine results in decreased expression of AANAT mRNA]; Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of AANAT mRNA]

NCBI chr10:101,827,072...101,831,805
Ensembl chr10:101,827,301...101,831,801

G

ATP binding cassette subfamily A member 1

decreases expression

Methamphetamine results in decreased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases expression

Melatonin inhibits the reaction [Methamphetamine results in decreased expression of ABCB1 protein]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 6

decreases expression
multiple interactions

Methamphetamine results in decreased expression of ABCC6 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of ABCC6 mRNA

PMID:19564919 PMID:25290377

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

ATP binding cassette subfamily D member 3

increases expression

Methamphetamine results in increased expression of ABCD3 mRNA

NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020

G

ATP binding cassette subfamily D member 4

decreases expression
multiple interactions

Methamphetamine results in decreased expression of ABCD4 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of ABCD4 mRNA

NCBI chr 6:104,246,459...104,260,965
Ensembl chr 6:104,246,468...104,280,276

G

ATP binding cassette subfamily G member 1

decreases expression

Methamphetamine results in decreased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

ATP binding cassette subfamily G member 2

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of ABCG2 mRNA
Methamphetamine results in decreased expression of ABCG2 mRNA

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

increases expression

Methamphetamine results in increased expression of ABL1 mRNA

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

actin-binding LIM protein 1

increases expression

Methamphetamine results in increased expression of ABLIM1 mRNA

PMID:26307267 PMID:32035215

NCBI chr 1:256,083,747...256,372,075
Ensembl chr 1:256,084,297...256,371,969

G

histo-blood group ABO system transferase 2

increases expression

Methamphetamine results in increased expression of ABO2 mRNA

NCBI chr 3:10,011,475...10,028,397
Ensembl chr 3:10,002,834...10,028,396

G

actin-binding Rho activating protein

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] affects the expression of ABRA mRNA
Methamphetamine results in increased expression of ABRA mRNA

NCBI chr 7:72,970,187...72,974,255
Ensembl chr 7:72,970,186...72,974,255

G

acetyl-CoA carboxylase beta

increases expression

Methamphetamine results in increased expression of ACACB mRNA

NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655

G

apoptotic chromatin condensation inducer 1

increases expression

Methamphetamine results in increased expression of ACIN1 mRNA

NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001

G

aconitase 1

increases expression

Methamphetamine results in increased expression of ACO1 protein

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

increases expression

Methamphetamine results in increased expression of ACO2 protein

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA thioesterase 1

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of ACOT1 mRNA
Methamphetamine results in decreased expression of ACOT1 mRNA

NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163

G

acyl-CoA oxidase 3, pristanoyl

increases expression

Methamphetamine results in increased expression of ACOX3 mRNA

NCBI chr14:75,133,986...75,176,767
Ensembl chr14:75,094,676...75,176,205

G

acrosin binding protein

increases expression

Methamphetamine results in increased expression of ACRBP mRNA

NCBI chr 4:157,851,149...157,864,211
Ensembl chr 4:157,841,841...157,864,213

G

acyl-CoA synthetase long-chain family member 5

increases expression
multiple interactions

Methamphetamine results in increased expression of ACSL5 mRNA
Lithium inhibits the reaction [Methamphetamine results in increased expression of ACSL5 mRNA]

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

acyl-CoA synthetase long-chain family member 6

affects response to substance

ACSL6 gene SNP affects the susceptibility to Methamphetamine

NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757

G

actin alpha 2, smooth muscle

increases expression

Methamphetamine results in increased expression of ACTA2 protein

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, beta

decreases expression

Methamphetamine results in decreased expression of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin, alpha, cardiac muscle 1

decreases expression

Methamphetamine results in decreased expression of ACTC1 mRNA

NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523

G

actin, gamma 1

decreases expression

Methamphetamine results in decreased expression of ACTG1 protein

NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232

G

activin A receptor like type 1

decreases methylation

Methamphetamine results in decreased methylation of ACVRL1 promoter

NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591

G

ADAM metallopeptidase domain 15

increases expression

Methamphetamine results in increased expression of ADAM15 mRNA

NCBI chr 2:174,754,629...174,765,136
Ensembl chr 2:174,754,633...174,765,113

G

ADAM metallopeptidase with thrombospondin type 1 motif, 9

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of ADAMTS9 mRNA
Methamphetamine results in increased expression of ADAMTS9 mRNA

PMID:19564919 PMID:26307267

NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929

G

ADAMTS-like 5

increases expression

Methamphetamine results in increased expression of ADAMTSL5 mRNA

NCBI chr 7:9,362,623...9,371,248
Ensembl chr 7:9,363,237...9,370,285

G

aarF domain containing kinase 2

decreases expression

Methamphetamine results in decreased expression of ADCK2 mRNA

NCBI chr 4:68,348,853...68,362,725
Ensembl chr 4:68,348,864...68,374,608

G

aarF domain containing kinase 5

decreases expression

Methamphetamine results in decreased expression of ADCK5 mRNA

NCBI chr 7:108,301,623...108,319,439
Ensembl chr 7:108,301,415...108,319,436

G

adenylate cyclase 3

multiple interactions
decreases expression

(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester inhibits the reaction [Methamphetamine results in decreased expression of ADCY3 mRNA]

NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686

G

adenylate cyclase 4

increases expression

Methamphetamine results in increased expression of ADCY4 mRNA

NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108

G

adenylate cyclase 6

increases expression

Methamphetamine results in increased expression of ADCY6 mRNA

PMID:26307267 PMID:36914120

NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754

G

adducin 2

increases expression

Methamphetamine results in increased expression of ADD2 mRNA

NCBI chr 4:118,444,594...118,538,505
Ensembl chr 4:118,497,416...118,538,505

G

adhesion G protein-coupled receptor F5

increases expression

Methamphetamine results in increased expression of ADGRF5 mRNA

NCBI chr 9:17,517,596...17,624,107
Ensembl chr 9:17,520,009...17,623,968

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression

Methamphetamine results in decreased expression of ADH1 mRNA

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

adiponectin, C1Q and collagen domain containing

decreases expression

Methamphetamine results in decreased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adenosine A1 receptor

multiple interactions

[8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein] inhibits the reaction [[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine]; [Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine
[N(6)-cyclohexyladenosine binds to and results in increased activity of ADORA1 protein] promotes the reaction [Methamphetamine results in increased secretion of Dopamine]; [N(6)-cyclohexyladenosine binds to and results in increased activity of ADORA1 protein] which results in increased susceptibility to Methamphetamine

PMID:7996441 PMID:11043458

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2a receptor

increases response to substance

ADORA2A gene SNP results in increased susceptibility to Methamphetamine

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adenosine A3 receptor

decreases expression
affects response to substance

Methamphetamine results in decreased expression of ADORA3 mRNA
ADORA3 affects the susceptibility to Methamphetamine

PMID:19564919 PMID:21867746

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

ADP-dependent glucokinase

decreases expression

Methamphetamine results in decreased expression of ADPGK mRNA

NCBI chr 8:59,699,400...59,727,352
Ensembl chr 8:59,699,388...59,727,351

G

adrenoceptor alpha 1B

affects response to substance

ADRA1B protein affects the susceptibility to Methamphetamine

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

G

AGBL carboxypeptidase 5

increases expression

Methamphetamine results in increased expression of AGBL5 mRNA

NCBI chr 6:25,472,333...25,492,173
Ensembl chr 6:25,472,333...25,490,738

G

agmatinase

decreases expression

Methamphetamine results in decreased expression of AGMAT mRNA

NCBI chr 5:154,043,665...154,074,278
Ensembl chr 5:154,060,151...154,074,276

G

agrin

increases expression

Methamphetamine results in increased expression of AGRN mRNA

NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003

G

angiotensinogen

increases expression
multiple interactions

Methamphetamine results in increased expression of AGT protein
candesartan cilexetil promotes the reaction [Methamphetamine results in increased expression of AGT protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

increases expression

Methamphetamine results in increased expression of AGTR1A protein

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

AHNAK nucleoprotein

increases expression

Methamphetamine results in increased expression of AHNAK mRNA

NCBI chr 1:205,882,225...205,970,934
Ensembl chr 1:205,882,273...205,970,926

G

activator of HSP90 ATPase homolog 2

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of AHSA2 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of AHSA2 mRNA]

NCBI chr14:97,476,304...97,485,725
Ensembl chr14:97,476,817...97,485,657

G

allograft inflammatory factor 1

increases expression
multiple interactions

Methamphetamine results in increased expression of AIF1 protein
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]]; CCK protein alternative form inhibits the reaction [Methamphetamine results in increased expression of AIF1 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of AIF1 protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]; Minocycline inhibits the reaction [Methamphetamine results in increased expression of AIF1 protein]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]; PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]; SNCA gene mutant form inhibits the reaction [Methamphetamine results in increased expression of AIF1 protein]

PMID:26283213 PMID:29467000 PMID:32278788 PMID:32916201

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

adherens junctions associated protein 1

increases expression

Methamphetamine results in increased expression of AJAP1 mRNA

NCBI chr 5:163,907,846...164,021,004
Ensembl chr 5:163,907,847...164,020,317

G

adenylate kinase 1

decreases expression

Methamphetamine results in decreased expression of AK1 protein

NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041

G

adenylate kinase 5

affects response to substance

AK5 gene SNP affects the susceptibility to Methamphetamine

NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458

G

A-kinase anchoring protein 13

increases expression

Methamphetamine results in increased expression of AKAP13 mRNA

NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646

G

A-kinase anchoring protein 8 like

increases expression

Methamphetamine results in increased expression of AKAP8L mRNA

NCBI chr 7:11,332,671...11,362,287
Ensembl chr 7:11,332,672...11,362,275

G

aldo-keto reductase family 7, member A2

decreases methylation

Methamphetamine results in decreased methylation of AKR7A5 promoter

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

AKT serine/threonine kinase 1

increases response to substance
increases phosphorylation
increases cleavage
decreases phosphorylation
multiple interactions
affects phosphorylation

AKT1 gene SNP results in increased susceptibility to Methamphetamine
Methamphetamine results in increased phosphorylation of AKT1 protein
Methamphetamine results in increased cleavage of AKT1 protein
Methamphetamine results in decreased phosphorylation of AKT1 protein
DDIT3 protein affects the reaction [Methamphetamine results in decreased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Methamphetamine results in decreased expression of and results in decreased phosphorylation of AKT1 protein; VEGFA protein affects the reaction [Methamphetamine results in increased phosphorylation of AKT1 protein]
[Rosiglitazone co-treated with Methamphetamine] results in increased phosphorylation of AKT1 protein; VEGFA protein affects the reaction [Methamphetamine results in increased phosphorylation of AKT1 protein]
Methamphetamine affects the phosphorylation of AKT1 protein
rosiglitazone inhibits the reaction [Methamphetamine results in decreased phosphorylation of AKT1 protein]

PMID:15982448 PMID:26887589 PMID:29981415 PMID:30742852 PMID:31270305 More...

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member A1

decreases expression

Methamphetamine results in decreased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member A2

increases expression

Methamphetamine results in increased expression of ALDH1A2 mRNA

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

aldehyde dehydrogenase 2 family member

decreases expression

Methamphetamine results in decreased expression of ALDH2 mRNA

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldolase, fructose-bisphosphate C

multiple interactions
increases expression
affects localization

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the localization of ALDOC mRNA]
Methamphetamine results in increased expression of ALDOC protein

PMID:18299792 PMID:19826936

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of ALG1 mRNA
Methamphetamine results in decreased expression of ALG1 mRNA

NCBI chr10:10,346,538...10,356,768
Ensembl chr10:10,346,536...10,356,750

G

ALS2 C-terminal like

increases expression

Methamphetamine results in increased expression of ALS2CL mRNA

NCBI chr 8:110,863,753...110,884,434
Ensembl chr 8:110,864,975...110,884,419

G

amidohydrolase domain containing 2

decreases expression

Methamphetamine results in decreased expression of AMDHD2 mRNA

NCBI chr10:13,187,579...13,196,148
Ensembl chr10:13,187,578...13,196,095

G

adenosine monophosphate deaminase 1

increases expression

Methamphetamine results in increased expression of AMPD1 mRNA

NCBI chr 2:190,598,707...190,619,938
Ensembl chr 2:190,598,700...190,619,938

G

adenosine monophosphate deaminase 3

decreases expression

Methamphetamine results in decreased expression of AMPD3 mRNA

NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887

G

angel homolog 1

decreases expression

Methamphetamine results in decreased expression of ANGEL1 mRNA

NCBI chr 6:106,349,125...106,386,202
Ensembl chr 6:106,349,126...106,386,209

G

angiopoietin 2

increases expression

Methamphetamine results in increased expression of ANGPT2 mRNA

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

angiopoietin-like 2

decreases expression

Methamphetamine results in decreased expression of ANGPTL2 mRNA

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178

G

ankyrin repeat domain 1

decreases expression

Methamphetamine results in decreased expression of ANKRD1 mRNA

NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919

G

ankyrin repeat domain containing 11

increases expression

Methamphetamine results in increased expression of ANKRD11 mRNA

NCBI chr19:50,940,284...51,098,962
Ensembl chr19:50,940,299...51,098,962

G

ankyrin repeat domain 16

decreases expression

Methamphetamine results in decreased expression of ANKRD16 mRNA

NCBI chr17:66,735,325...66,748,533
Ensembl chr17:66,737,261...66,748,533

G

ankyrin repeat domain 44

decreases expression
multiple interactions

Methamphetamine results in decreased expression of ANKRD44 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of ANKRD44 mRNA

NCBI chr 9:56,126,746...56,427,661
Ensembl chr 9:56,126,747...56,427,508

G

ankyrin repeat domain 9

increases expression

Methamphetamine results in increased expression of ANKRD9 mRNA

NCBI chr 6:130,001,914...130,008,792
Ensembl chr 6:129,998,486...130,008,923

G

ankyrin repeat and sterile alpha motif domain containing 1B

decreases expression

Methamphetamine results in decreased expression of ANKS1B mRNA

NCBI chr 7:24,313,339...25,479,307
Ensembl chr 7:24,312,843...25,477,693

G

anoctamin 3

decreases expression

Methamphetamine results in decreased expression of ANO3 mRNA

NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154

G

anoctamin 6

increases expression

Methamphetamine results in increased expression of ANO6 mRNA

NCBI chr 7:126,933,919...127,113,588
Ensembl chr 7:126,933,936...127,113,589

G

annexin A3

decreases expression

Methamphetamine results in decreased expression of ANXA3 protein

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

acyloxyacyl hydrolase

affects response to substance

AOAH gene SNP affects the susceptibility to Methamphetamine

NCBI chr17:43,808,110...44,049,458
Ensembl chr17:43,809,638...44,049,148

G

adaptor related protein complex 1 subunit beta 1

increases expression

Methamphetamine results in increased expression of AP1B1 mRNA

NCBI chr14:79,879,482...79,930,778
Ensembl chr14:79,879,533...79,930,778

G

apurinic/apyrimidinic endodeoxyribonuclease 2

increases expression

Methamphetamine results in increased expression of APEX2 mRNA

NCBI chr X:19,425,684...19,508,459
Ensembl chr X:19,487,419...19,508,439

G

apelin receptor

decreases expression
multiple interactions

Methamphetamine results in decreased expression of APLNR mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of APLNR mRNA

NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050

G

apolipoprotein A2

decreases expression

Methamphetamine results in decreased expression of APOA2 mRNA

NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355

G

apolipoprotein D

decreases expression

Methamphetamine results in decreased expression of APOD mRNA

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

apolipoprotein L domain containing 1

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of APOLD1 mRNA
Methamphetamine results in increased expression of APOLD1 mRNA

NCBI chr 4:167,768,437...167,825,706
Ensembl chr 4:167,818,271...167,825,706

G

amyloid beta precursor protein

multiple interactions
increases expression
increases secretion

Methamphetamine results in increased expression of and results in increased cleavage of APP protein
Methamphetamine results in increased expression of APP protein
Rosiglitazone inhibits the reaction [Methamphetamine results in increased expression of APP protein]
Methamphetamine results in increased secretion of APP protein

PMID:30367931 PMID:31270305

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2

increases expression

Methamphetamine results in increased expression of APPL2 mRNA

NCBI chr 7:20,135,248...20,184,757
Ensembl chr 7:20,135,375...20,184,754

G

androgen receptor

increases expression

Methamphetamine results in increased expression of AR mRNA

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

increases expression

Methamphetamine results in increased expression of ARAP3 mRNA

NCBI chr18:29,806,214...29,834,217
Ensembl chr18:29,807,536...29,833,555

G

activity-regulated cytoskeleton-associated protein

multiple interactions
increases expression

CTAP octapeptide inhibits the reaction [Methamphetamine results in increased expression of ARC mRNA]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ARC mRNA]

PMID:11085305 PMID:19564919 PMID:20298714

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

amphiregulin

decreases expression

Methamphetamine results in decreased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

arginase 2

multiple interactions
increases expression

Lithium inhibits the reaction [Methamphetamine results in increased expression of ARG2 mRNA]; Valproic Acid inhibits the reaction [Methamphetamine results in increased expression of ARG2 mRNA]

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

G

Rho GTPase activating protein 29

increases expression

Methamphetamine results in increased expression of ARHGAP29 mRNA

NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028

G

Rho GTPase activating protein 9

increases methylation

Methamphetamine results in increased methylation of ARHGAP9 promoter

NCBI chr 7:63,148,573...63,157,025
Ensembl chr 7:63,148,900...63,157,524

G

Rho GDP dissociation inhibitor alpha

increases expression

Methamphetamine results in increased expression of ARHGDIA protein

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

Rho guanine nucleotide exchange factor 1

increases expression

Methamphetamine results in increased expression of ARHGEF1 mRNA

NCBI chr 1:80,499,026...80,520,954
Ensembl chr 1:80,499,131...80,520,953

G

Rho guanine nucleotide exchange factor 10

increases expression

Methamphetamine results in increased expression of ARHGEF10 mRNA

NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173

G

Rho guanine nucleotide exchange factor 15

increases expression

Methamphetamine results in increased expression of ARHGEF15 mRNA

NCBI chr10:53,650,521...53,663,269
Ensembl chr10:53,650,553...53,663,913

G

Rho/Rac guanine nucleotide exchange factor 2

increases expression

Methamphetamine results in increased expression of ARHGEF2 mRNA

NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355

G

Rho guanine nucleotide exchange factor 25

increases methylation

Methamphetamine results in increased methylation of ARHGEF25 promoter

NCBI chr 7:63,005,938...63,013,325
Ensembl chr 7:63,005,940...63,013,719

G

AT-rich interaction domain 1A

increases methylation
increases expression

Methamphetamine results in increased methylation of ARID1A promoter
Methamphetamine results in increased expression of ARID1A mRNA

NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564

G

ariadne RBR E3 ubiquitin protein ligase 1

increases expression

Methamphetamine results in increased expression of ARIH1 mRNA

NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245

G

ARF like GTPase 14 effector protein

decreases expression

Methamphetamine results in decreased expression of ARL14EP mRNA

NCBI chr 3:93,441,952...93,454,282
Ensembl chr 3:93,443,183...93,454,155

G

ARF like GTPase 5B

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of ARL5B mRNA
Methamphetamine results in increased expression of ARL5B mRNA

NCBI chr17:77,955,864...77,979,895
Ensembl chr17:77,955,818...77,979,854

G

aryl hydrocarbon receptor nuclear translocator 2

increases expression

Methamphetamine results in increased expression of ARNT2 mRNA

NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153

G

arrestin, beta 2

increases response to substance

ARRB2 gene SNP results in increased susceptibility to Methamphetamine

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

arrestin domain containing 2

increases expression

Methamphetamine results in increased expression of ARRDC2 mRNA

NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029

G

ankyrin repeat and SOCS box-containing 14

increases expression

Methamphetamine results in increased expression of ASB14 mRNA

NCBI chr16:2,095,567...2,123,259
Ensembl chr16:2,095,644...2,115,135

G

acid sensing ion channel subunit 3

increases expression

Methamphetamine results in increased expression of ASIC3 mRNA

NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643

G

argininosuccinate lyase

decreases expression

Methamphetamine results in decreased expression of ASL mRNA

NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662

G

assembly factor for spindle microtubules

decreases expression

Methamphetamine results in decreased expression of ASPM mRNA

NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755

G

astrotactin 2

affects response to substance

ASTN2 gene SNP affects the susceptibility to Methamphetamine

NCBI chr 5:78,758,142...79,744,021
Ensembl chr 5:78,758,142...79,748,273

G

activating transcription factor 3

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of ATF3 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ATF3 mRNA]
Methamphetamine results in increased expression of ATF3 mRNA; Methamphetamine results in increased expression of ATF3 protein

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 4

multiple interactions
increases expression

SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ATF4 mRNA]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ATF4 protein]
ATF4 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; ATF4 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]; ATF4 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; ATF4 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]; EIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of ATF4 protein]
Methamphetamine results in increased expression of ATF4 mRNA; Methamphetamine results in increased expression of ATF4 protein

PMID:19564919 PMID:27323860

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

increases expression
increases cleavage
affects localization
multiple interactions

Methamphetamine results in increased expression of ATF6 mRNA; Methamphetamine results in increased expression of ATF6 protein
Methamphetamine results in increased cleavage of ATF6 protein
Methamphetamine affects the localization of ATF6 protein
ATF6 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; ATF6 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]; ATF6 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; ATF6 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]; ATF6 protein affects the reaction [Methamphetamine results in increased expression of XBP1 mRNA]; ATF6 protein affects the reaction [Methamphetamine results in increased expression of XBP1 protein]; Methamphetamine results in decreased expression of and results in increased cleavage of ATF6 protein; Naltrexone inhibits the reaction [Methamphetamine results in increased cleavage of ATF6 protein]; norbinaltorphimine inhibits the reaction [Methamphetamine results in increased cleavage of ATF6 protein]
Melatonin inhibits the reaction [Methamphetamine results in increased expression of ATF6 protein]

PMID:19564919 PMID:27323860 PMID:28070110 PMID:34214594

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

activating transcription factor 6 beta

increases expression
multiple interactions

Methamphetamine results in increased expression of ATF6B protein
4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of ATF6B protein]

NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894

G

autophagy related 14

increases expression

Methamphetamine results in increased expression of ATG14 mRNA

NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113

G

autophagy related 16-like 1

increases expression

Methamphetamine results in increased expression of ATG16L1 mRNA

NCBI chr 9:88,420,737...88,457,530
Ensembl chr 9:88,422,038...88,457,529

G

autophagy related 2A

increases expression

Methamphetamine results in increased expression of ATG2A mRNA

NCBI chr 1:203,542,559...203,562,242
Ensembl chr 1:203,542,559...203,562,242

G

autophagy related 5

increases expression
multiple interactions

Methamphetamine results in increased expression of ATG5 mRNA; Methamphetamine results in increased expression of ATG5 protein
Luteolin inhibits the reaction [Methamphetamine results in increased expression of ATG5 protein]

PMID:32035215 PMID:32676729 PMID:33359793 PMID:34374793

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

ATPase Na+/K+ transporting subunit alpha 1

decreases expression

Methamphetamine results in decreased expression of ATP1A1 mRNA

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

increases expression

Methamphetamine results in increased expression of ATP2A1 mRNA

NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions
decreases expression

Lithium inhibits the reaction [Methamphetamine results in decreased expression of ATP2A2 mRNA]

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

ATP synthase F1 subunit beta

decreases expression

Methamphetamine results in decreased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase peripheral stalk subunit d

decreases expression

Methamphetamine results in decreased expression of ATP5PD protein

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

ATPase H+ transporting V0 subunit a1

increases expression

Methamphetamine results in increased expression of ATP6V0A1 mRNA

NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895

G

ATPase, H+ transporting V0 subunit e2

increases expression

Methamphetamine results in increased expression of ATP6V0E2 mRNA

NCBI chr 4:77,484,868...77,488,016
Ensembl chr 4:77,482,226...77,488,777

G

ATPase H+ transporting V1 subunit B2

decreases expression

Methamphetamine results in decreased expression of ATP6V1B2 protein

PMID:16181420 PMID:19826936

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

ATPase H+ transporting V1 subunit C2

decreases expression

Methamphetamine results in decreased expression of ATP6V1C2 mRNA

NCBI chr 6:40,080,545...40,144,199
Ensembl chr 6:40,080,547...40,120,028

G

ataxin 2

increases expression

Methamphetamine results in increased expression of ATXN2 mRNA

NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479

G

ataxin 2-like

increases expression

Methamphetamine results in increased expression of ATXN2L mRNA

NCBI chr 1:181,078,293...181,090,079
Ensembl chr 1:181,078,288...181,089,686

G

ataxin 7-like 1

increases expression

Methamphetamine results in increased expression of ATXN7L1 mRNA

NCBI chr 6:49,759,876...49,982,323
Ensembl chr 6:49,759,883...49,982,320

G

aurora kinase C

decreases expression

Methamphetamine results in decreased expression of AURKC mRNA

NCBI chr 1:66,843,653...66,849,775
Ensembl chr 1:66,843,653...66,864,386

G

arginine vasopressin

affects expression
multiple interactions

Methamphetamine affects the expression of AVP mRNA
[Methamphetamine co-treated with SCH 23390] affects the expression of AVP mRNA

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

Beta-1,3-galactosyltransferase 4

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of B3GALT4 mRNA
Methamphetamine results in decreased expression of B3GALT4 mRNA

NCBI chr20:4,936,089...4,937,664
Ensembl chr20:4,931,768...4,938,315

G

beta-secretase 1

increases expression

Methamphetamine results in increased expression of BACE1 protein

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BTB domain and CNC homolog 2

decreases expression

Methamphetamine results in decreased expression of BACH2 mRNA

NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877

G

BAI1-associated protein 3

increases expression

Methamphetamine results in increased expression of BAIAP3 mRNA

NCBI chr10:14,260,269...14,273,019
Ensembl chr10:14,260,269...14,273,019

G

BCL2-antagonist/killer 1

multiple interactions
increases expression

[N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BAK1 protein
Methamphetamine results in increased expression of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

Btg3 associated nuclear protein

increases expression

Methamphetamine results in increased expression of BANP mRNA

NCBI chr19:50,007,710...50,082,742
Ensembl chr19:50,007,881...50,082,738

G

BRCA1 associated RING domain 1

decreases expression

Methamphetamine results in decreased expression of BARD1 mRNA

NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of BAX protein]; BBC3 protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; Lithium inhibits the reaction [Methamphetamine results in increased expression of BAX protein]; Luteolin inhibits the reaction [Methamphetamine results in increased expression of BAX protein]; Valproic Acid inhibits the reaction [Methamphetamine results in increased expression of BAX protein]
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]]; 6-formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene inhibits the reaction [Methamphetamine results in increased expression of BAX protein]; EPHX1 protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of BAX protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]; PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]; PRKCD protein affects the reaction [Methamphetamine results in increased expression of BAX protein]
Methamphetamine results in increased expression of BAX mRNA; Methamphetamine results in increased expression of BAX protein
[N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BAX mRNA; [N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BAX protein; BBC3 protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; SNCA protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; TXN protein inhibits the reaction [Methamphetamine results in increased expression of BAX protein]

PMID:19149911 PMID:23820845 PMID:26307267 PMID:26524635 PMID:26923100 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bromodomain adjacent to zinc finger domain, 1B

increases expression

Methamphetamine results in increased expression of BAZ1B mRNA

NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426

G

bromodomain adjacent to zinc finger domain, 2A

increases expression

Methamphetamine results in increased expression of BAZ2A mRNA

NCBI chr 7:523,204...560,911
Ensembl chr 7:523,265...560,659

G

Bcl-2 binding component 3

multiple interactions
increases expression

[N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BBC3 mRNA; [N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BBC3 protein; BBC3 protein affects the reaction [Methamphetamine results in decreased cleavage of CASP3 protein]; BBC3 protein affects the reaction [Methamphetamine results in decreased cleavage of PARP1 protein]; BBC3 protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; BBC3 protein affects the reaction [Methamphetamine results in increased expression of BAX protein]
Methamphetamine results in increased expression of BBC3 protein
BBC3 protein promotes the reaction [Methamphetamine results in increased expression of NOS2 protein]
4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of BBC3 protein]; BBC3 protein affects the reaction [Methamphetamine results in decreased cleavage of CASP3 protein]; BBC3 protein affects the reaction [Methamphetamine results in decreased cleavage of PARP1 protein]; BBC3 protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; BBC3 protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased expression of BBC3 protein]
Methamphetamine results in increased expression of BBC3 mRNA; Methamphetamine results in increased expression of BBC3 protein

PMID:23820845 PMID:26524635 PMID:30394308 PMID:34214594

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

affects response to substance
increases expression
decreases expression
multiple interactions

BCL2 protein affects the susceptibility to Methamphetamine
Methamphetamine results in increased expression of BCL2 protein
Methamphetamine results in decreased expression of BCL2 protein
[N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in decreased expression of BCL2 mRNA; BBC3 protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; SNCA protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]
Methamphetamine results in decreased expression of BCL2 mRNA; Methamphetamine results in decreased expression of BCL2 protein
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]]; [6-formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene co-treated with Methamphetamine] results in increased expression of BCL2 protein; EPHX1 protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]; NOS1 protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]; PRKCD protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; SOD1 protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]
4-phenylbutyric acid inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]; bafilomycin A1 promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]; BBC3 protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; CEBPB protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; DDIT3 protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; GxTX-1E, Plesiophrictus guangxiensis inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]; Lithium inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]; Olanzapine inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]; STX17 protein inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]; Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]

PMID:11457507 PMID:12050851 PMID:15276877 PMID:19149911 PMID:23820845 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

affects expression
decreases expression
multiple interactions
increases methylation
increases expression

Methamphetamine affects the expression of BCL2L1 mRNA alternative form
Methamphetamine results in decreased expression of BCL2L1 protein
EPHX1 protein affects the reaction [Methamphetamine results in decreased expression of BCL2L1 protein]; PRKCD protein affects the reaction [Methamphetamine results in decreased expression of BCL2L1 protein]
Methamphetamine results in increased methylation of BCL2L1 promoter
Methamphetamine results in increased expression of BCL2L1 mRNA
Methamphetamine results in decreased expression of BCL2L1 mRNA
[N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in decreased expression of BCL2L1 mRNA

PMID:10336889 PMID:23820845 PMID:26307267 PMID:31422080

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

multiple interactions
increases expression

[N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BCL2L11 mRNA; [N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BCL2L11 protein
Methamphetamine results in increased expression of BCL2L11 protein
4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of BCL2L11 protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased expression of BCL2L11 protein]

PMID:23820845 PMID:34214594

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

Bcl2-like 15

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of BCL2L15 mRNA
Methamphetamine results in increased expression of BCL2L15 mRNA

NCBI chr 2:191,338,959...191,344,078
Ensembl chr 2:191,338,959...191,344,078

G

Bcl2-like 2

increases expression

Methamphetamine results in increased expression of BCL2L2 mRNA

NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624

G

BCL6, transcription repressor

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of BCL6 mRNA
Methamphetamine results in increased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

BCL9 like

increases expression

Methamphetamine results in increased expression of BCL9L mRNA

NCBI chr 8:44,811,977...44,840,611
Ensembl chr 8:44,811,977...44,840,611

G

3-hydroxybutyrate dehydrogenase 1

increases expression

Methamphetamine results in increased expression of BDH1 mRNA

NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671

G

brain-derived neurotrophic factor

increases response to substance
increases expression
multiple interactions
decreases expression
affects response to substance

BDNF gene SNP results in increased susceptibility to Methamphetamine
Methamphetamine results in increased expression of BDNF protein
gastrodin inhibits the reaction [Methamphetamine results in decreased expression of BDNF protein]; Metformin inhibits the reaction [Methamphetamine results in decreased expression of BDNF protein]
BDNF protein affects the susceptibility to Methamphetamine
BDNF gene polymorphism affects the susceptibility to Methamphetamine

PMID:15050682 PMID:16039058 PMID:19462300 PMID:20736000 PMID:27373168 More...

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

multiple interactions
increases expression
increases phosphorylation

CEBPB protein affects the reaction [Methamphetamine results in increased expression of BECN1 protein]; DDIT4 protein promotes the reaction [Methamphetamine results in increased expression of BECN1 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased expression of BECN1 protein]
6-formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene inhibits the reaction [Methamphetamine results in increased expression of BECN1 mRNA]; NFE2L2 protein affects the reaction [Methamphetamine results in increased expression of BECN1 protein]; sulforaphane inhibits the reaction [Methamphetamine results in increased expression of BECN1 protein]
Methamphetamine results in increased expression of BECN1 mRNA; Methamphetamine results in increased expression of BECN1 protein
Methamphetamine results in increased phosphorylation of BECN1 protein
DDIT4 protein affects the reaction [Methamphetamine results in increased expression of BECN1 protein]

PMID:26825372 PMID:31059759 PMID:31928234 PMID:32035215 PMID:32676729 More...

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

betaine-homocysteine S-methyltransferase 2

affects expression
multiple interactions

Methamphetamine affects the expression of BHMT2 mRNA
[Methamphetamine co-treated with SCH 23390] affects the expression of BHMT2 mRNA

NCBI chr 2:24,895,525...24,912,475
Ensembl chr 2:24,895,533...24,912,475

G

BH3 interacting domain death agonist

increases expression
multiple interactions

Methamphetamine results in increased expression of BID mRNA; Methamphetamine results in increased expression of BID protein modified form
[N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BID mRNA; [N-Methyl-3,4-methylenedioxyamphetamine co-treated with Methamphetamine co-treated with 4-methylthioamphetamine co-treated with Dextroamphetamine] results in increased expression of BID protein modified form

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

bridging integrator 1

decreases expression

Methamphetamine results in decreased expression of BIN1 protein

NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263

G

baculoviral IAP repeat-containing 5

decreases expression

Methamphetamine results in decreased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

basic helix-loop-helix ARNT like 1

increases expression

Methamphetamine results in increased expression of BMAL1 mRNA; Methamphetamine results in increased expression of BMAL1 protein

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

BCL2 interacting protein 3

increases expression

Methamphetamine results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

B-Raf proto-oncogene, serine/threonine kinase

increases expression

Methamphetamine results in increased expression of BRAF mRNA

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

bromodomain containing 2

increases expression

Methamphetamine results in increased expression of BRD2 mRNA

NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388

G

bromodomain containing 9

increases expression

Methamphetamine results in increased expression of BRD9 mRNA

NCBI chr 1:29,329,981...29,357,285
Ensembl chr 1:29,329,985...29,357,016

G

bromodomain and WD repeat domain containing 1

increases expression

Methamphetamine results in increased expression of BRWD1 mRNA

NCBI chr11:35,286,364...35,378,768
Ensembl chr11:35,288,313...35,378,768

G

B-box and SPRY domain containing

decreases expression

Methamphetamine results in decreased expression of BSPRY mRNA

NCBI chr 5:75,927,397...75,949,585
Ensembl chr 5:75,927,405...75,949,583

G

bone marrow stromal cell antigen 2

increases expression

Methamphetamine results in increased expression of BST2 mRNA

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

B-TFIID TATA-box binding protein associated factor 1

increases expression

Methamphetamine results in increased expression of BTAF1 mRNA

NCBI chr 1:234,653,219...234,743,903
Ensembl chr 1:234,653,156...234,743,903

G

BTG anti-proliferation factor 2

increases expression

Methamphetamine results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BUB1 mitotic checkpoint serine/threonine kinase B

decreases expression

Methamphetamine results in decreased expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

similar to human chromosome 16 open reading frame 89

decreases expression
multiple interactions

Methamphetamine results in decreased expression of C10H16ORF89 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of C10H16ORF89 mRNA

NCBI chr10:10,361,909...10,371,046
Ensembl chr10:10,361,948...10,371,046

G

similar to human chromosome 8 open reading frame 58

decreases expression
multiple interactions

Methamphetamine results in decreased expression of C15H8ORF58 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of C15H8ORF58 mRNA

NCBI chr15:45,228,615...45,235,274
Ensembl chr15:45,228,615...45,233,254

G

similar to human chromosome 16 open reading frame 87

increases expression

Methamphetamine results in increased expression of C19H16ORF87 mRNA

NCBI chr19:21,626,390...21,653,869
Ensembl chr19:21,626,914...21,654,255

G

complement C1q like 1

decreases expression

Methamphetamine results in decreased expression of C1QL1 mRNA

NCBI chr10:87,902,125...87,909,556
Ensembl chr10:87,902,137...87,909,310

G

C1q and TNF related 7

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of C1QTNF7 mRNA
Methamphetamine results in decreased expression of C1QTNF7 mRNA

NCBI chr14:67,467,888...67,580,477
Ensembl chr14:67,468,014...67,580,410

G

C2 calcium-dependent domain containing 2

increases expression

Methamphetamine results in increased expression of C2CD2 mRNA

NCBI chr11:37,225,321...37,289,741
Ensembl chr11:37,227,415...37,289,739

G

similar to human chromosome 3 open reading frame 33

decreases expression

Methamphetamine results in decreased expression of C2H3ORF33 mRNA

NCBI chr 2:148,376,598...148,404,343
Ensembl chr 2:148,380,581...148,404,387

G

similar to human chromosome 11 open reading frame 96

increases expression

Methamphetamine results in increased expression of C3H11ORF96 mRNA

NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523

G

complement component 4 binding protein, beta

decreases expression

Methamphetamine results in decreased expression of C4BPB mRNA

NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817

G

similar to human chromosome 1 open reading frame 210

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of C5H1ORF210 mRNA
Methamphetamine results in decreased expression of C5H1ORF210 mRNA

NCBI chr 5:132,048,755...132,051,913
Ensembl chr 5:132,048,773...132,051,925

G

complement C8 gamma chain

decreases expression

Methamphetamine results in decreased expression of C8G mRNA

NCBI chr 3:8,320,503...8,322,087
Ensembl chr 3:8,305,920...8,323,495

G

calcium binding protein 39-like

decreases expression

Methamphetamine results in decreased expression of CAB39L mRNA

NCBI chr15:33,606,588...33,710,518
Ensembl chr15:33,606,694...33,743,545

G

calcineurin binding protein 1

increases expression

Methamphetamine results in increased expression of CABIN1 mRNA

NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357

G

calcium binding tyrosine phosphorylation regulated

increases expression

Methamphetamine results in increased expression of CABYR mRNA

NCBI chr18:3,892,062...3,904,391
Ensembl chr18:3,892,132...3,903,840

G

calcium voltage-gated channel subunit alpha1 C

decreases methylation
increases expression

Methamphetamine results in decreased methylation of CACNA1C promoter
Methamphetamine results in increased expression of CACNA1C mRNA
Methamphetamine results in increased expression of CACNA1C mRNA; Methamphetamine results in increased expression of CACNA1C protein

PMID:26307267 PMID:35863504

NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648

G

calcium voltage-gated channel auxiliary subunit alpha2delta 1

affects response to substance
increases expression
multiple interactions

CACNA2D1 protein affects the susceptibility to Methamphetamine
Methamphetamine results in increased expression of CACNA2D1 mRNA; Methamphetamine results in increased expression of CACNA2D1 protein
[gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Methamphetamine; DRD1 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; DRD1 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]; DRD2 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; DRD2 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]; gabapentin inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]; Sulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; Sulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]

PMID:20340177 PMID:21182903

NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969

G

calcium voltage-gated channel auxiliary subunit beta 4

increases expression

Methamphetamine results in increased expression of CACNB4 mRNA

NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944

G

calcyclin binding protein

increases expression

Methamphetamine results in increased expression of CACYBP mRNA

NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177

G

calbindin 2

decreases expression

Methamphetamine results in decreased expression of CALB2 mRNA

NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438

G

calcium homeostasis modulator family member 2

increases expression

Methamphetamine results in increased expression of CALHM2 mRNA

NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218

G

calmodulin binding transcription activator 2

increases expression

Methamphetamine results in increased expression of CAMTA2 mRNA

NCBI chr10:55,383,450...55,401,838
Ensembl chr10:55,383,450...55,401,558

G

capping actin protein of muscle Z-line subunit beta

decreases expression

Methamphetamine results in decreased expression of CAPZB protein

NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409

G

carbonic anhydrase 1

increases expression

Methamphetamine results in increased expression of CAR1 protein

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

G

carbonic anhydrase 11

decreases expression

Methamphetamine results in decreased expression of CAR11 mRNA

NCBI chr 1:96,169,900...96,175,191
Ensembl chr 1:96,170,080...96,175,191

G

carbonic anhydrase 4

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of CAR4 mRNA
Methamphetamine results in decreased expression of CAR4 mRNA

NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501

G

carbonic anhydrase 5B

increases expression
multiple interactions

Methamphetamine results in increased expression of CAR5B mRNA
Valproic Acid inhibits the reaction [Methamphetamine results in increased expression of CAR5B mRNA]

NCBI chr X:30,474,697...30,534,797
Ensembl chr X:30,474,784...30,533,837

G

calcium regulated heat stable protein 1

decreases expression

Methamphetamine results in decreased expression of CARHSP1 mRNA

NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019

G

carnosine synthase 1

increases expression

Methamphetamine results in increased expression of CARNS1 mRNA

NCBI chr 1:201,459,061...201,470,019
Ensembl chr 1:201,459,076...201,469,845

G

caspase 1

multiple interactions
increases expression
increases cleavage

MIR143 mRNA affects the reaction [Methamphetamine results in increased cleavage of CASP1 protein]; PYCARD protein promotes the reaction [Methamphetamine results in increased cleavage of CASP1 protein]
Methamphetamine results in increased expression of CASP1 protein

PMID:30394308 PMID:33359793

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 12

increases cleavage
decreases expression
multiple interactions
increases expression

Methamphetamine results in increased cleavage of CASP12 protein
Methamphetamine results in decreased expression of CASP12 protein
CDK5 protein affects the reaction [Methamphetamine results in increased expression of CASP12 protein]; TXN protein inhibits the reaction [Methamphetamine results in decreased expression of CASP12 protein]
Methamphetamine results in increased expression of CASP12 mRNA; Methamphetamine results in increased expression of CASP12 protein
CDK5 protein affects the reaction [Methamphetamine results in increased expression of CASP12 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased cleavage of CASP12 protein]

PMID:28070110 PMID:28619521 PMID:29705343 PMID:32203791

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 2

increases expression

Methamphetamine results in increased expression of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

multiple interactions
increases activity
decreases expression
increases cleavage
decreases cleavage
affects cleavage
increases expression

3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]]; 6-formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene inhibits the reaction [Methamphetamine results in increased activity of CASP3 protein]; [Methamphetamine co-treated with tin protoporphyrin IX] results in increased cleavage of CASP3 protein; ginsenoside Re inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]; JUN protein affects the reaction [Methamphetamine results in increased activity of CASP3 protein]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]; PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]
Methamphetamine results in decreased expression of CASP3 protein
Methamphetamine results in decreased cleavage of CASP3 protein
ATF4 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; ATF6 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; BBC3 protein affects the reaction [Methamphetamine results in decreased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; EIF2AK3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; ERN1 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; Methamphetamine results in increased expression of and results in increased cleavage of CASP3 protein; PRKCD protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; RELA protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; SNCA protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; TXN protein inhibits the reaction [Methamphetamine results in decreased expression of CASP3 protein]
Methamphetamine affects the cleavage of CASP3 protein
2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; BBC3 protein affects the reaction [Methamphetamine results in decreased cleavage of CASP3 protein]; CASP4 protein alternative form affects the reaction [Methamphetamine results in increased cleavage of and results in increased activity of CASP3 protein]; CEBPB protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; DDIT4 protein promotes the reaction [Methamphetamine results in increased expression of CASP3 protein modified form]; diadenosine tetraphosphate inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; GxTX-1E, Plesiophrictus guangxiensis inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; IGFBP5 mutant form inhibits the reaction [Methamphetamine results in increased activity of CASP3 protein]; KN 93 inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; Lactulose inhibits the reaction [Methamphetamine results in increased expression of CASP3 protein modified form]; Luteolin inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; Methamphetamine results in increased cleavage of and results in increased activity of CASP3 protein; Nifedipine inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; STX17 protein inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; W 7 inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; wedelolactone inhibits the reaction [Methamphetamine results in increased cleavage of and results in increased activity of CASP3 protein]
Methamphetamine results in increased expression of CASP3 mRNA; Methamphetamine results in increased expression of CASP3 protein modified form

PMID:12391261 PMID:19149911 PMID:19442829 PMID:23933405 PMID:25127757 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

multiple interactions
increases expression

CASP4 protein alternative form affects the reaction [Methamphetamine results in increased cleavage of and results in increased activity of CASP3 protein]; CASP4 protein alternative form affects the reaction [Methamphetamine results in increased cleavage of PARP1 protein]; Lithium inhibits the reaction [Methamphetamine results in increased expression of CASP4 mRNA]; Valproic Acid inhibits the reaction [Methamphetamine results in increased expression of CASP4 mRNA]
Methamphetamine results in increased expression of CASP4 mRNA; Methamphetamine results in increased expression of CASP4 protein alternative form

PMID:19149911 PMID:25631491 PMID:28619521

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 6

increases cleavage

Methamphetamine results in increased cleavage of CASP6 protein

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 9

multiple interactions
increases activity
increases cleavage

ATF4 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]; ATF6 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]; EIF2AK3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]; ERN1 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]; Methamphetamine results in increased expression of and results in increased cleavage of CASP9 protein; RELA protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]
6-formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene inhibits the reaction [Methamphetamine results in increased activity of CASP9 protein]

PMID:27323860 PMID:31928234 PMID:32676729

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases expression
increases activity
multiple interactions
decreases activity

Methamphetamine results in decreased expression of CAT protein
Methamphetamine results in increased activity of CAT protein
ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of CAT protein]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of CAT protein]]; PRKCD affects the reaction [Methamphetamine results in increased activity of CAT protein]
Methamphetamine results in decreased activity of CAT protein
linalool inhibits the reaction [Methamphetamine results in decreased activity of CAT protein]; Taurine inhibits the reaction [Methamphetamine results in decreased activity of CAT protein]

PMID:12797468 PMID:19948197 PMID:23041169 PMID:24430743 PMID:29467000 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

increases expression

Methamphetamine results in increased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

Cbl proto-oncogene like 1

increases expression

Methamphetamine results in increased expression of CBLL1 mRNA

NCBI chr 6:48,071,190...48,086,174
Ensembl chr 6:48,071,190...48,086,444

G

carbonyl reductase 1

decreases expression

Methamphetamine results in decreased expression of CBR1 mRNA

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

chromobox 1

decreases expression

Methamphetamine results in decreased expression of CBX1 mRNA

NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096

G

chromobox 8

decreases expression

Methamphetamine results in decreased expression of CBX8 mRNA

NCBI chr10:104,294,518...104,296,956
Ensembl chr10:104,294,518...104,297,024

G

coiled-coil and C2 domain containing 1B

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of CC2D1B mRNA
Methamphetamine results in decreased expression of CC2D1B mRNA

NCBI chr 5:123,353,289...123,367,343
Ensembl chr 5:123,353,292...123,367,318

G

coiled-coil domain containing 116

increases expression

Methamphetamine results in increased expression of CCDC116 mRNA

NCBI chr11:83,842,707...83,850,607
Ensembl chr11:83,845,557...83,850,607

G

coiled-coil domain containing 117

increases expression
multiple interactions

Methamphetamine results in increased expression of CCDC117 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of CCDC117 mRNA

NCBI chr14:80,399,236...80,409,824
Ensembl chr14:80,400,294...80,409,659

G

coiled-coil domain containing 51

increases methylation

Methamphetamine results in increased methylation of CCDC51 promoter

NCBI chr 8:109,722,595...109,741,478
Ensembl chr 8:109,722,557...109,741,472

G

coiled-coil domain containing 57

decreases expression

Methamphetamine results in decreased expression of CCDC57 mRNA

NCBI chr10:106,092,784...106,196,405
Ensembl chr10:106,092,947...106,196,077

G

coiled-coil alpha-helical rod protein 1

affects response to substance

CCHCR1 gene SNP affects the susceptibility to Methamphetamine

NCBI chr20:3,205,675...3,218,437
Ensembl chr20:3,205,676...3,218,308

G

cholecystokinin

multiple interactions

CCK protein modified form inhibits the reaction [Methamphetamine promotes the reaction [NCF1 protein binds to CYBB protein]]; CCK protein modified form inhibits the reaction [Methamphetamine results in increased phosphorylation of NCF1 protein]
CCK protein alternative form inhibits the reaction [Methamphetamine results in increased expression of AIF1 protein]; CCK protein alternative form inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA]; CCK protein alternative form inhibits the reaction [Methamphetamine results in increased expression of IL6 protein]; CCK protein alternative form inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; CCK protein alternative form inhibits the reaction [Methamphetamine results in increased expression of TNF protein]; CCK protein alternative form inhibits the reaction [Methamphetamine results in increased phosphorylation of NFKBIA protein]; CCK protein alternative form inhibits the reaction [Methamphetamine results in increased phosphorylation of RELA protein]; CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]; CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of TNF protein]; Devazepide promotes the reaction [CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]]; Devazepide promotes the reaction [CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of TNF protein]]; L 365260 inhibits the reaction [CCK protein alternative form inhibits the reaction [Methamphetamine results in increased phosphorylation of NFKBIA protein]]; L 365260 inhibits the reaction [CCK protein alternative form inhibits the reaction [Methamphetamine results in increased phosphorylation of RELA protein]]; L 365260 inhibits the reaction [CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]]; L 365260 inhibits the reaction [CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of TNF protein]]

PMID:27565679 PMID:32916201

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

cholecystokinin B receptor

increases expression

Methamphetamine results in increased expression of CCKBR mRNA

NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881

G

C-C motif chemokine ligand 12

increases expression

Methamphetamine results in increased expression of CCL12 mRNA

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

G

C-C motif chemokine ligand 4

increases expression

Methamphetamine results in increased expression of CCL4 mRNA

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

decreases expression

Methamphetamine results in decreased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 9

increases expression

Methamphetamine results in increased expression of CCL6 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

cellular communication network factor 1

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of CCN1 mRNA
Methamphetamine results in increased expression of CCN1 mRNA

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cyclin A1

multiple interactions
decreases expression

Lithium inhibits the reaction [Methamphetamine results in decreased expression of CCNA1 mRNA]

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin A2

decreases expression

Methamphetamine results in decreased expression of CCNA2 mRNA; Methamphetamine results in decreased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

Methamphetamine results in decreased expression of CCNB1 mRNA; Methamphetamine results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

decreases expression

Methamphetamine results in decreased expression of CCNB2 mRNA
Methamphetamine results in decreased expression of CCNB2 mRNA; Methamphetamine results in decreased expression of CCNB2 protein

PMID:25290377 PMID:28341135

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

decreases expression
multiple interactions

Methamphetamine results in decreased expression of CCND1 mRNA
Lithium inhibits the reaction [Methamphetamine results in decreased expression of CCND1 mRNA]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

decreases expression

Methamphetamine results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin L1

increases expression

Methamphetamine results in increased expression of CCNL1 mRNA

NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368

G

cyclin L2

increases expression

Methamphetamine results in increased expression of CCNL2 mRNA

NCBI chr 5:166,416,940...166,428,997
Ensembl chr 5:166,417,508...166,436,882

G

C-C motif chemokine receptor 2

increases response to substance
increases expression
increases methylation

CCR2 protein results in increased susceptibility to Methamphetamine
Methamphetamine results in increased expression of CCR2 mRNA
Methamphetamine results in increased methylation of CCR2 promoter

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 5

decreases expression
multiple interactions

Methamphetamine results in decreased expression of CCR5 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of CCR5 mRNA

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

C-C motif chemokine receptor 7

decreases expression

Methamphetamine results in decreased expression of CCR7 mRNA

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

chaperonin containing TCP1 subunit 2

decreases expression

Methamphetamine results in decreased expression of CCT2 protein

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

G

chaperonin containing TCP1 subunit 5

decreases expression

Methamphetamine results in decreased expression of CCT5 protein

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

CD151 molecule (Raph blood group)

increases expression

Methamphetamine results in increased expression of CD151 mRNA

NCBI chr 1:196,564,744...196,568,753
Ensembl chr 1:196,565,181...196,568,753

G

CD177 molecule

increases expression

Methamphetamine results in increased expression of CD177 mRNA

NCBI chr 1:80,340,034...80,360,599
Ensembl chr 1:80,340,034...80,360,621

G

CD36 molecule

increases expression

Methamphetamine results in increased expression of CD36 mRNA; Methamphetamine results in increased expression of CD36 protein

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD3 delta subunit of T-cell receptor complex

multiple interactions
increases expression

CDK5 protein affects the reaction [Methamphetamine results in increased expression of CD3D protein]

NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809

G

Cd4 molecule

decreases expression
multiple interactions

methamphetamine decreases expression of Cd4 protein in spleen
methamphetamine cotreated with ionomycin decreases expression of Cd4 protein in spleen

RGD

PMID:25678251 PMID:25678251

RGD:407446373, RGD:407446373

NCBI chr 4:157,668,878...157,695,366
Ensembl chr 4:157,668,878...157,695,191

G

CD55 molecule (Cromer blood group)

affects response to substance

CD55 gene SNP affects the susceptibility to Methamphetamine

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

G

CD8 subunit alpha

increases expression

methamphetamine increases expression of CD8a protein in spleen

RGD

NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040

G

CDC42 effector protein 3

increases expression

Methamphetamine results in increased expression of CDC42EP3 mRNA

NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721

G

cell division cycle 45

decreases expression

Methamphetamine results in decreased expression of CDC45 mRNA

NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619

G

cell division cycle associated 3

decreases expression

Methamphetamine results in decreased expression of CDCA3 mRNA; Methamphetamine results in decreased expression of CDCA3 protein

NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799

G

cell division cycle associated 7

decreases expression

Methamphetamine results in decreased expression of CDCA7 mRNA

NCBI chr 3:57,322,718...57,333,353
Ensembl chr 3:57,322,708...57,333,353

G

cell division cycle associated 8

decreases expression

Methamphetamine results in decreased expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

G

cadherin 13

affects response to substance

CDH13 gene SNP affects the susceptibility to Methamphetamine

NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459

G

cadherin 5

increases expression
multiple interactions

Methamphetamine results in increased expression of CDH5 mRNA
Luteolin inhibits the reaction [Methamphetamine results in increased expression of CDH5 mRNA]

NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368

G

cadherin-related family member 2

decreases expression

Methamphetamine results in decreased expression of CDHR2 mRNA

NCBI chr17:9,876,853...9,913,356
Ensembl chr17:9,876,860...9,912,575

G

cyclin-dependent kinase 1

increases expression
decreases expression

Methamphetamine results in increased expression of CDK1 mRNA
Methamphetamine results in decreased expression of CDK1 mRNA; Methamphetamine results in decreased expression of CDK1 protein

PMID:15644446 PMID:28341135

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 10

decreases expression

Methamphetamine results in decreased expression of CDK10 mRNA

NCBI chr19:51,260,012...51,273,009
Ensembl chr19:51,261,356...51,269,078

G

cyclin-dependent kinase 5

multiple interactions
increases expression

CDK5 protein affects the reaction [Methamphetamine results in increased expression of CASP12 protein]; CDK5 protein affects the reaction [Methamphetamine results in increased expression of CD3D protein]; CDK5 protein affects the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein]; CDK5 protein affects the reaction [Methamphetamine results in increased phosphorylation of MAPT protein]
methamphetamine increases expression of Cdk5 protein in the ventral tegmental area and nucleus accumbens
Methamphetamine results in increased expression of CDK5 protein
SNCA gene mutant form inhibits the reaction [Methamphetamine results in increased expression of CDK5 protein]

CTD
RGD

PMID:29705343 PMID:32278788 PMID:28782589

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

G

cyclin-dependent kinase 6

increases expression

Methamphetamine results in increased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase 9

increases expression

Methamphetamine results in increased expression of CDK9 mRNA

NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of CDKN1A mRNA; GATA4 protein affects the reaction [Methamphetamine results in increased expression of CDKN1A protein]
Methamphetamine results in increased expression of CDKN1A mRNA; Methamphetamine results in increased expression of CDKN1A protein

PMID:19564919 PMID:36914120

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

multiple interactions
increases expression

GATA4 protein affects the reaction [Methamphetamine results in increased expression of CDKN2A protein]

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2B

increases expression

Methamphetamine results in increased expression of CDKN2B mRNA

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

cysteine rich, DPF motif domain containing 1

decreases expression

Methamphetamine results in decreased expression of CDPF1 mRNA

NCBI chr 7:116,896,672...116,905,438
Ensembl chr 7:116,901,003...116,905,406

G

cerebellar degeneration-related protein 2

increases expression

Methamphetamine results in increased expression of CDR2 mRNA

NCBI chr 1:175,502,837...175,527,746
Ensembl chr 1:175,502,838...175,537,472

G

CDP-diacylglycerol synthase 2

increases expression

Methamphetamine results in increased expression of CDS2 mRNA

NCBI chr 3:119,514,963...119,553,555
Ensembl chr 3:119,515,000...119,553,541

G

CCAAT/enhancer binding protein beta

increases expression
multiple interactions

Methamphetamine results in increased expression of CEBPB mRNA; Methamphetamine results in increased expression of CEBPB protein
CEBPB protein affects the reaction [Methamphetamine results in decreased expression of PRKN protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of TRIB3 protein]
[Methamphetamine co-treated with SCH 23390] results in increased expression of CEBPB mRNA; CEBPB protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; CEBPB protein affects the reaction [Methamphetamine results in decreased expression of PRKN protein]; CEBPB protein affects the reaction [Methamphetamine results in decreased phosphorylation of MTOR protein]; CEBPB protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; CEBPB protein affects the reaction [Methamphetamine results in increased cleavage of PARP1 protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of BECN1 protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of DDIT4 protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of SNCA protein]; CEBPB protein affects the reaction [Methamphetamine results in increased expression of TRIB3 protein]; CEBPB protein affects the reaction [Methamphetamine results in increased phosphorylation of TSC2 protein]

PMID:19564919 PMID:31059759

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

chymotrypsin like elastase 1

decreases expression

Methamphetamine results in decreased expression of CELA1 mRNA

NCBI chr 7:131,773,161...131,786,300
Ensembl chr 7:131,742,002...131,786,285

G

centromere protein H

decreases expression

Methamphetamine results in decreased expression of CENPH mRNA

NCBI chr 2:31,896,675...31,910,179
Ensembl chr 2:31,894,667...31,910,154

G

centromere protein Q

decreases expression

Methamphetamine results in decreased expression of CENPQ mRNA

NCBI chr 9:19,957,122...19,972,807
Ensembl chr 9:19,957,048...19,972,789

G

centromere protein W

decreases expression

Methamphetamine results in decreased expression of CENPW mRNA

NCBI chr 1:27,525,324...27,530,464
Ensembl chr 1:27,525,324...27,530,464

G

centrosomal protein 104

multiple interactions
affects expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of CEP104 mRNA
Methamphetamine affects the expression of CEP104 mRNA

NCBI chr 5:164,534,773...164,567,260
Ensembl chr 5:164,534,782...164,567,248

G

centrosomal protein 55

decreases expression

Methamphetamine results in decreased expression of CEP55 mRNA

NCBI chr 1:235,832,823...235,848,401
Ensembl chr 1:235,832,878...235,848,394

G

centrosomal protein 72

decreases expression

Methamphetamine results in decreased expression of CEP72 mRNA

NCBI chr 1:29,225,312...29,255,294
Ensembl chr 1:29,225,361...29,255,271

G

centrosomal protein 95

decreases expression

Methamphetamine results in decreased expression of CEP95 mRNA

NCBI chr10:91,732,111...91,760,095
Ensembl chr10:91,732,111...91,760,092

G

ceramide transporter 1

increases expression

Methamphetamine results in increased expression of CERT1 mRNA

NCBI chr 2:27,882,546...27,987,090
Ensembl chr 2:27,882,555...27,987,074

G

CGG triplet repeat binding protein 1

increases expression

Methamphetamine results in increased expression of CGGBP1 mRNA

NCBI chr11:2,565,629...2,572,869
Ensembl chr11:2,565,484...2,573,031

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

Methamphetamine results in increased expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

choline O-acetyltransferase

decreases activity

Methamphetamine results in decreased activity of CHAT protein

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

chromodomain helicase DNA binding protein 4

decreases methylation
increases expression

Methamphetamine results in decreased methylation of CHD4 promoter
Methamphetamine results in increased expression of CHD4 mRNA

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

G

calcium homeostasis endoplasmic reticulum protein

increases expression

Methamphetamine results in increased expression of CHERP mRNA

NCBI chr16:17,367,455...17,380,507
Ensembl chr16:17,367,455...17,380,507

G

choline kinase beta

increases expression

Methamphetamine results in increased expression of CHKB mRNA

NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461

G

cysteine and histidine rich domain containing 1

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of CHORDC1 mRNA
Methamphetamine results in increased expression of CHORDC1 mRNA

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

cholinergic receptor nicotinic beta 1 subunit

increases expression

Methamphetamine results in increased expression of CHRNB1 mRNA

NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345

G

cholinergic receptor nicotinic epsilon subunit

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of CHRNE mRNA
Methamphetamine results in increased expression of CHRNE mRNA

NCBI chr10:55,331,211...55,339,923
Ensembl chr10:55,331,212...55,335,530

G

chromosome transmission fidelity factor 18

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of CHTF18 mRNA
Methamphetamine results in decreased expression of CHTF18 mRNA

NCBI chr10:14,743,006...14,751,044
Ensembl chr10:14,742,621...14,751,050

G

cytokine induced apoptosis inhibitor 1

increases expression

Methamphetamine results in increased expression of CIAPIN1 mRNA

NCBI chr19:10,179,963...10,195,511
Ensembl chr19:10,180,100...10,195,503

G

capicua transcriptional repressor

increases expression

Methamphetamine results in increased expression of CIC mRNA

NCBI chr 1:80,853,920...80,880,537
Ensembl chr 1:80,853,920...80,880,532

G

cell death-inducing DFFA-like effector a

increases expression

Methamphetamine results in increased expression of CIDEA mRNA; Methamphetamine results in increased expression of CIDEA protein

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cold inducible RNA binding protein

decreases expression

Methamphetamine results in decreased expression of CIRBP mRNA

NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

increases expression

Methamphetamine results in increased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4

multiple interactions
increases expression
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of CITED4 mRNA
Methamphetamine results in increased expression of CITED4 mRNA
Methamphetamine results in decreased expression of CITED4 mRNA

PMID:19564919 PMID:36914120

NCBI chr 5:134,246,936...134,247,827
Ensembl chr 5:134,246,682...134,248,135

G

cytoskeleton associated protein 2

decreases expression

Methamphetamine results in decreased expression of CKAP2 mRNA

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

creatine kinase B

increases expression

Methamphetamine results in increased expression of CKB protein

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

CLK4-associating serine/arginine rich protein

increases expression
decreases expression

Methamphetamine results in increased expression of SFRS16 mRNA
Methamphetamine results in decreased expression of CLASRP mRNA

PMID:26307267 PMID:32035215

NCBI chr 1:79,232,260...79,256,462
Ensembl chr 1:79,232,261...79,256,354

G

chloride voltage-gated channel 6

increases expression

Methamphetamine results in increased expression of CLCN6 mRNA

NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059

G

chloride voltage-gated channel Kb

decreases expression
affects methylation

Methamphetamine results in decreased expression of CLCNKB mRNA
Methamphetamine affects the methylation of CLCNKB promoter

NCBI chr 5:153,710,086...153,733,162
Ensembl chr 5:153,710,094...153,732,153

G

claudin 5

decreases expression
multiple interactions

Methamphetamine results in decreased expression of CLDN5 mRNA
[Neomycin co-treated with Metronidazole co-treated with Ampicillin co-treated with Vancomycin] inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 mRNA]; [Neomycin co-treated with Metronidazole co-treated with Ampicillin co-treated with Vancomycin] inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 protein]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 mRNA]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 protein]
Methamphetamine results in decreased expression of CLDN5 mRNA; Methamphetamine results in decreased expression of CLDN5 protein

PMID:19564919 PMID:35390362 PMID:36720452

NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992

G

C-type lectin domain family 4, member E

decreases expression

Methamphetamine results in decreased expression of CLEC4E mRNA

NCBI chr 4:156,606,927...156,612,911
Ensembl chr 4:156,607,614...156,612,767

G

chloride intracellular channel 4

increases expression

Methamphetamine results in increased expression of CLIC4 mRNA

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

G

CAP-GLY domain containing linker protein 1

increases expression

Methamphetamine results in increased expression of CLIP1 mRNA

PMID:19564919 PMID:26307267

NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884

G

caseinolytic mitochondrial matrix peptidase chaperone subunit X

increases expression

Methamphetamine results in increased expression of CLPX mRNA

NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082

G

clustered mitochondria homolog

increases expression

Methamphetamine results in increased expression of CLUH mRNA

NCBI chr10:59,509,580...59,531,345
Ensembl chr10:59,509,726...59,531,345

G

clavesin 2

increases expression
multiple interactions

Methamphetamine results in increased expression of CLVS2 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of CLVS2 mRNA

NCBI chr 1:23,735,660...23,842,685
Ensembl chr 1:23,735,272...23,842,692

G

CKLF-like MARVEL transmembrane domain containing 3

decreases methylation

Methamphetamine results in decreased methylation of CMTM3 promoter

NCBI chr19:622,563...630,721
Ensembl chr19:604,458...629,790

G

CKLF-like MARVEL transmembrane domain containing 8

decreases expression

Methamphetamine results in decreased expression of CMTM8 mRNA

NCBI chr 8:114,481,730...114,547,107
Ensembl chr 8:114,481,982...114,547,083

G

CCR4-NOT transcription complex, subunit 6-like

increases expression
multiple interactions

Methamphetamine results in increased expression of CNOT6L mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of CNOT6L mRNA

NCBI chr14:13,410,499...13,502,511
Ensembl chr14:13,411,281...13,498,203

G

2',3'-cyclic nucleotide 3' phosphodiesterase

multiple interactions
decreases expression

SNCA protein affects the reaction [Methamphetamine results in decreased expression of CNP protein]; TFEB protein inhibits the reaction [Methamphetamine results in decreased expression of CNP protein]

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

G

cannabinoid receptor 1

affects response to substance

CNR1 protein affects the susceptibility to Methamphetamine

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

ciliary neurotrophic factor receptor

increases expression

Methamphetamine results in increased expression of CNTFR mRNA

NCBI chr 5:56,823,448...56,861,049
Ensembl chr 5:56,823,965...56,841,392

G

contactin 2

decreases expression

Methamphetamine results in decreased expression of CNTN2 mRNA

NCBI chr13:43,942,868...43,975,973
Ensembl chr13:43,947,265...43,975,887

G

contactin associated protein family member 5B

decreases expression

Methamphetamine results in decreased expression of CNTNAP5A mRNA

NCBI chr13:17,863,367...18,766,983
Ensembl chr13:18,093,420...18,761,014

G

collagen type X alpha 1 chain

increases expression

Methamphetamine results in increased expression of COL10A1 mRNA

NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494

G

collagen type XV alpha 1 chain

decreases expression

Methamphetamine results in decreased expression of COL15A1 mRNA

NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591

G

collagen type XXV alpha 1 chain

decreases expression

Methamphetamine results in decreased expression of COL25A1 mRNA

NCBI chr 2:218,755,152...219,154,348
Ensembl chr 2:218,755,691...219,153,501

G

collagen type XXVIII alpha 1 chain

affects response to substance

COL28A1 gene SNP affects the susceptibility to Methamphetamine

NCBI chr 4:36,069,980...36,223,128
Ensembl chr 4:36,069,970...36,223,220

G

collagen type III alpha 1 chain

decreases expression

Methamphetamine results in decreased expression of COL3A1 mRNA

PMID:19564919 PMID:36914120

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type VI alpha 2 chain

decreases expression

Methamphetamine results in decreased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

catechol-O-methyltransferase

increases response to substance
affects response to substance

COMT gene polymorphism results in increased susceptibility to Methamphetamine
COMT gene polymorphism affects the susceptibility to Methamphetamine

PMID:15274053 PMID:19462300

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

COPI coat complex subunit beta 2

increases expression

Methamphetamine results in increased expression of COPB2 mRNA

NCBI chr 8:99,161,324...99,183,452
Ensembl chr 8:99,161,350...99,185,197

G

coenzyme Q10B

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of COQ10B mRNA
Methamphetamine results in increased expression of COQ10B mRNA

NCBI chr 9:56,553,751...56,573,671
Ensembl chr 9:56,553,758...56,573,663

G

coenzyme Q8A

increases expression
decreases methylation

Methamphetamine results in increased expression of COQ8A mRNA
Methamphetamine results in decreased methylation of COQ8A promoter

NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431

G

corin, serine peptidase

increases expression

Methamphetamine results in increased expression of CORIN mRNA

NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503

G

coronin 6

increases expression

Methamphetamine results in increased expression of CORO6 mRNA

NCBI chr10:62,311,552...62,319,659
Ensembl chr10:62,311,660...62,319,659

G

cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10

increases expression

Methamphetamine results in increased expression of COX10 mRNA

NCBI chr10:48,630,993...48,742,805
Ensembl chr10:48,630,676...48,746,667

G

ceruloplasmin

multiple interactions
decreases expression

linalool inhibits the reaction [Methamphetamine results in decreased expression of CP protein]

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

cytoplasmic polyadenylation element binding protein 3

increases expression

Methamphetamine results in increased expression of CPEB3 mRNA

NCBI chr 1:234,749,138...234,931,219
Ensembl chr 1:234,751,733...234,931,560

G

complexin 1

increases expression

Methamphetamine results in increased expression of CPLX1 protein

NCBI chr14:1,184,677...1,216,392

G

complexin 2

increases expression

Methamphetamine results in increased expression of CPLX2 protein

NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855

G

ceramide-1-phosphate transfer protein

decreases methylation

Methamphetamine results in decreased methylation of CPTP promoter

NCBI chr 5:166,474,947...166,479,103
Ensembl chr 5:166,474,966...166,479,017

G

carboxypeptidase Z

increases expression

Methamphetamine results in increased expression of CPZ mRNA

NCBI chr14:75,223,692...75,246,946
Ensembl chr14:75,223,605...75,246,945

G

cellular retinoic acid binding protein 1

decreases expression

Methamphetamine results in decreased expression of CRABP1 mRNA

NCBI chr 8:55,138,363...55,159,360
Ensembl chr 8:55,151,285...55,159,360

G

cAMP responsive element binding protein 1

multiple interactions
decreases phosphorylation
increases activity
increases expression

gastrodin inhibits the reaction [Methamphetamine results in decreased phosphorylation of CREB1 protein]; Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of CREB1 protein]; Methamphetamine results in decreased expression of and results in decreased phosphorylation of CREB1 protein
methamphetamine increases activity of Creb1 protein in the ventral tegmental area and nucleus accumbens
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of CREB1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of CREB1 protein]
Methamphetamine results in increased expression of CREB1 mRNA; Methamphetamine results in increased expression of CREB1 protein

CTD
RGD

PMID:30742852 PMID:32162539 PMID:33421459 PMID:28782589

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element binding protein 3-like 1

increases expression

Methamphetamine results in increased expression of CREB3L1 mRNA

NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456

G

cysteine-rich with EGF-like domains 2

increases expression

Methamphetamine results in increased expression of CRELD2 mRNA

PMID:19564919 PMID:36914120

NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543

G

cAMP responsive element modulator

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of CREM mRNA
Methamphetamine results in increased expression of CREM mRNA

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

corticotropin releasing hormone

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of CRH mRNA
Methamphetamine results in increased expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

corticotropin releasing hormone receptor 1

multiple interactions

[CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Methamphetamine

NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481

G

cysteine-rich secretory protein LCCL domain containing 1

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of CRISPLD1 mRNA
Methamphetamine results in decreased expression of CRISPLD1 mRNA

NCBI chr 5:1,267,347...1,314,926
Ensembl chr 5:1,274,647...1,314,926

G

CRK proto-oncogene, adaptor protein

decreases expression

Methamphetamine results in decreased expression of CRK protein

NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406

G

CRK like proto-oncogene, adaptor protein

increases expression

Methamphetamine results in increased expression of CRKL mRNA

NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238

G

CREB regulated transcription coactivator 2

increases expression

Methamphetamine results in increased expression of CRTC2 mRNA

NCBI chr 2:175,709,603...175,719,768
Ensembl chr 2:175,709,644...175,719,763

G

cryptochrome circadian regulator 1

decreases expression

Methamphetamine results in decreased expression of CRY1 mRNA

NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091

G

cryptochrome circadian regulator 2

increases expression

Methamphetamine results in increased expression of CRY2 mRNA

NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965

G

crystallin, alpha B

increases expression
multiple interactions

Methamphetamine results in increased expression of CRYAB mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of CRYAB mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of CRYAB mRNA]

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

crystallin, mu

increases expression

Methamphetamine results in increased expression of CRYM protein

NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633

G

citrate synthase

increases expression

Methamphetamine results in increased expression of CS mRNA

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

cold shock domain containing C2

increases expression

Methamphetamine results in increased expression of CSDC2 mRNA

NCBI chr 7:113,451,998...113,466,464
Ensembl chr 7:113,451,998...113,466,463

G

colony stimulating factor 1

increases expression

Methamphetamine results in increased expression of CSF1 mRNA

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

colony stimulating factor 1 receptor

increases expression

Methamphetamine results in increased expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 2

increases expression

Methamphetamine results in increased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

CUB and Sushi multiple domains 1

affects response to substance

CSMD1 gene SNP affects the susceptibility to Methamphetamine

NCBI chr16:72,218,189...73,818,380
Ensembl chr16:72,218,503...73,817,614

G

casein alpha s1

increases expression

Methamphetamine results in increased expression of CSN1S1 mRNA

NCBI chr14:20,343,620...20,359,614
Ensembl chr14:20,343,619...20,359,614

G

cysteine and glycine-rich protein 2

decreases expression
multiple interactions

Methamphetamine results in decreased expression of CSRP2 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of CSRP2 mRNA

NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745

G

cystatin 11

increases methylation

Methamphetamine results in increased methylation of CST11 promoter

NCBI chr 3:136,211,414...136,214,138
Ensembl chr 3:136,211,414...136,214,138

G

cystatin B

affects expression

Methamphetamine affects the expression of CSTB protein

NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526

G

C-terminal binding protein 2

decreases methylation
increases expression

Methamphetamine results in decreased methylation of CTBP2 promoter
Methamphetamine results in increased expression of CTBP2 mRNA

NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222

G

catenin beta 1

multiple interactions
increases expression

Lithium inhibits the reaction [Methamphetamine results in increased expression of CTNNB1 mRNA]

PMID:19149911 PMID:32035215

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

chymotrypsin-like

increases expression

Methamphetamine results in increased expression of CTRL mRNA

NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626

G

cathepsin B

increases activity

Methamphetamine results in increased activity of CTSB protein

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

affects localization

Methamphetamine affects the localization of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cubilin

affects response to substance

CUBN gene SNP affects the susceptibility to Methamphetamine

NCBI chr17:76,385,046...76,593,133
Ensembl chr17:76,385,060...76,593,231

G

CUE domain containing 1

increases expression

Methamphetamine results in increased expression of CUEDC1 mRNA

NCBI chr10:72,892,637...72,986,546
Ensembl chr10:72,892,637...72,986,542

G

cullin 2

decreases expression

Methamphetamine results in decreased expression of CUL2 mRNA

NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968

G

cullin 9

increases expression

Methamphetamine results in increased expression of CUL9 mRNA

NCBI chr 9:14,435,948...14,479,552
Ensembl chr 9:14,436,111...14,479,548

G

cut-like homeobox 1

increases expression

Methamphetamine results in increased expression of CUX1 mRNA

NCBI chr12:20,107,062...20,425,868
Ensembl chr12:20,107,311...20,425,866
Ensembl chr 4:20,107,311...20,425,866

G

CWC25 spliceosome-associated protein homolog

increases expression

Methamphetamine results in increased expression of CWC25 mRNA

NCBI chr10:82,735,698...82,760,373
Ensembl chr10:82,736,995...82,760,354

G

C-X3-C motif chemokine receptor 1

decreases expression

Methamphetamine results in decreased expression of CX3CR1 mRNA

NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014

G

C-X-C motif chemokine ligand 10

increases expression

Methamphetamine results in increased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

multiple interactions
increases expression

Luteolin inhibits the reaction [Methamphetamine results in increased expression of CXCL12 mRNA]

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 2

increases expression

Methamphetamine results in increased expression of CXCL2 mRNA

PMID:25290377 PMID:36914120

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

increases expression

Methamphetamine results in increased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome b5 type B

increases expression

Methamphetamine results in increased expression of CYB5B mRNA

NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249

G

cytochrome b-245 beta chain

multiple interactions

CCK protein modified form inhibits the reaction [Methamphetamine promotes the reaction [NCF1 protein binds to CYBB protein]]; Methamphetamine promotes the reaction [NCF1 protein binds to CYBB protein]

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome c, somatic

increases expression

Methamphetamine results in increased expression of CYCS mRNA

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression

Methamphetamine results in increased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects metabolic processing

CYP1A2 protein affects the metabolism of Methamphetamine metabolite

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 27, subfamily a, polypeptide 1

multiple interactions
decreases expression

Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of CYP27A1 mRNA]

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects response to substance
increases metabolic processing

CYP2D4 gene polymorphism affects the susceptibility to Methamphetamine; CYP2D6 protein affects the susceptibility to Methamphetamine
CYP2D6 protein results in increased metabolism of Methamphetamine

PMID:18280655 PMID:20727252 PMID:27320963

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects metabolic processing

CYP2E1 protein affects the metabolism of Methamphetamine metabolite

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily j, polypeptide 10

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of CYP2J10 mRNA
Methamphetamine results in decreased expression of CYP2J10 mRNA

NCBI chr 5:110,960,319...110,995,220
Ensembl chr 5:110,960,317...110,995,115

G

cytochrome P450, family 2, subfamily t, polypeptide 1

decreases expression

Methamphetamine results in decreased expression of CYP2T1 mRNA

NCBI chr 1:82,446,321...82,451,564
Ensembl chr 1:82,446,921...82,451,563

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects metabolic processing
multiple interactions

CYP3A4 protein affects the metabolism of Methamphetamine metabolite
[Methamphetamine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA

PMID:12851153 PMID:16038959

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 4, subfamily a, polypeptide 8

increases expression

Methamphetamine results in increased expression of CYP4A8 mRNA

NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476

G

cytochrome P450, family 4, subfamily f, polypeptide 4

decreases expression

Methamphetamine results in decreased expression of CYP4F4 mRNA

NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506

G

cytochrome P450 family 7 subfamily B member 1

decreases expression

Methamphetamine results in decreased expression of CYP7B1 mRNA

NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698

G

cytohesin 1

increases expression

Methamphetamine results in increased expression of CYTH1 mRNA

NCBI chr10:103,402,727...103,485,826
Ensembl chr10:103,366,145...103,485,760

G

cysteine and tyrosine rich 1

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of CYYR1 mRNA
Methamphetamine results in decreased expression of CYYR1 mRNA

NCBI chr11:24,557,620...24,664,007
Ensembl chr11:24,515,316...24,663,961

G

CXXC motif containing zinc binding protein

decreases expression

Methamphetamine results in decreased expression of CZIB mRNA

NCBI chr 5:122,648,333...122,657,767
Ensembl chr 5:122,648,411...122,656,910

G

defender against cell death 1

increases expression
multiple interactions

Methamphetamine results in increased expression of DAD1 mRNA
SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DAD1 mRNA]

NCBI chr15:27,677,286...27,697,120
Ensembl chr15:27,677,268...27,697,347

G

dopamine beta-hydroxylase

decreases expression

Methamphetamine results in decreased expression of DBH protein

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

G

D-box binding PAR bZIP transcription factor

increases expression
decreases expression
affects expression

Methamphetamine results in increased expression of DBP mRNA
Methamphetamine results in decreased expression of DBP mRNA
Methamphetamine affects the expression of DBP mRNA

PMID:26307267 PMID:35863504 PMID:36914120

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

dendrocyte expressed seven transmembrane protein

affects response to substance

DCSTAMP gene SNP affects the susceptibility to Methamphetamine

NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078

G

dynactin subunit 1

decreases expression

Methamphetamine results in decreased expression of DCTN1 mRNA; Methamphetamine results in decreased expression of DCTN1 protein

NCBI chr 4:115,671,024...115,703,824
Ensembl chr 4:115,661,638...115,703,815

G

dimethylarginine dimethylaminohydrolase 1

affects expression

Methamphetamine affects the expression of DDAH1 protein

NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339

G

DNA-damage inducible transcript 3

multiple interactions
affects localization
increases expression

4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]; [Methamphetamine co-treated with SCH 23390] results in increased expression of DDIT3 mRNA; DDIT3 protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; DDIT3 protein affects the reaction [Methamphetamine results in decreased phosphorylation of AKT1 protein]; DDIT3 protein affects the reaction [Methamphetamine results in decreased phosphorylation of FOXO3 protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased cleavage of PARP1 protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased expression of BBC3 protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased expression of BCL2L11 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]; Methamphetamine promotes the reaction [FOXO3 protein binds to DDIT3 protein]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]
Methamphetamine affects the localization of DDIT3 protein
Methamphetamine results in increased expression of DDIT3 mRNA; Methamphetamine results in increased expression of DDIT3 protein
ATF4 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; ATF4 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]; ATF6 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; ATF6 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]; EIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; EIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]; ERN1 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; ERN1 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]; Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]; norbinaltorphimine inhibits the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; norbinaltorphimine inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]; RELA protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; RELA protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]; TXN protein inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]

PMID:15644446 PMID:19564919 PMID:27323860 PMID:28070110 PMID:28619521 More...

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

multiple interactions
increases expression
increases response to substance

[Methamphetamine co-treated with SCH 23390] results in increased expression of DDIT4 mRNA; CEBPB protein affects the reaction [Methamphetamine results in increased expression of DDIT4 protein]; DDIT4 protein promotes the reaction [Methamphetamine results in decreased phosphorylation of MTOR protein]; DDIT4 protein promotes the reaction [Methamphetamine results in increased expression of BECN1 protein]; DDIT4 protein promotes the reaction [Methamphetamine results in increased expression of CASP3 protein modified form]; DDIT4 protein promotes the reaction [Methamphetamine results in increased expression of DDIT4 protein]; DDIT4 protein promotes the reaction [Methamphetamine results in increased expression of PARP1 protein modified form]
DDIT4 protein affects the reaction [Methamphetamine results in decreased phosphorylation of MTOR protein]; DDIT4 protein affects the reaction [Methamphetamine results in increased expression of BECN1 protein]; DDIT4 protein affects the reaction [Methamphetamine results in increased phosphorylation of TSC2 protein]
Methamphetamine results in increased expression of DDIT4 mRNA; Methamphetamine results in increased expression of DDIT4 protein
DDIT4 protein results in increased susceptibility to Methamphetamine

PMID:19564919 PMID:26825372 PMID:31059759

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

D-dopachrome tautomerase

affects expression

Methamphetamine affects the expression of DDT protein

NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482

G

DEAD-box helicase 10

increases expression

Methamphetamine results in increased expression of DDX10 mRNA

NCBI chr 8:53,488,656...53,643,373
Ensembl chr 8:53,488,656...53,643,373

G

DEAD-box helicase 17

increases expression

Methamphetamine results in increased expression of DDX17 mRNA

NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193

G

DExD-box helicase 21

multiple interactions
decreases expression

Lithium inhibits the reaction [Methamphetamine results in decreased expression of DDX21 mRNA]

NCBI chr20:30,534,319...30,554,513
Ensembl chr20:30,534,319...30,554,543

G

DExD-box helicase 52

decreases expression

Methamphetamine results in decreased expression of DDX52 mRNA

NCBI chr10:68,824,594...68,847,400
Ensembl chr10:68,824,645...68,848,266

G

DEAF1 transcription factor

increases expression

Methamphetamine results in increased expression of DEAF1 mRNA

NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541

G

DENN domain containing 5A

increases expression

Methamphetamine results in increased expression of DENND5A mRNA

NCBI chr 1:163,928,183...163,994,207
Ensembl chr 1:163,928,183...163,994,316

G

DEP domain containing 1

decreases expression

Methamphetamine results in decreased expression of DEPDC1 mRNA

NCBI chr 2:248,684,508...248,717,951
Ensembl chr 2:248,684,523...248,717,951

G

DEPP autophagy regulator 1

decreases expression

Methamphetamine results in decreased expression of DEPP1 mRNA

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

diacylglycerol O-acyltransferase 2

increases expression

Methamphetamine results in increased expression of DGAT2 mRNA

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

G

diacylglycerol kinase, beta

decreases expression

Methamphetamine results in decreased expression of DGKB mRNA

NCBI chr 6:54,640,948...55,397,210
Ensembl chr 6:54,641,614...55,397,043

G

diacylglycerol kinase, gamma

increases expression

Methamphetamine results in increased expression of DGKG mRNA

NCBI chr11:78,384,212...78,579,158
Ensembl chr11:78,384,458...78,577,212

G

diacylglycerol kinase, eta

increases expression

Methamphetamine results in increased expression of DGKH mRNA

NCBI chr15:53,981,079...54,150,470
Ensembl chr15:53,991,481...54,150,706

G

diacylglycerol kinase zeta

increases expression

Methamphetamine results in increased expression of DGKZ mRNA

NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:77,904,150...77,946,099

G

24-dehydrocholesterol reductase

increases expression

Methamphetamine results in increased expression of DHCR24 mRNA

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

DEAH-box helicase 16

increases expression

Methamphetamine results in increased expression of DHX16 mRNA

NCBI chr20:2,862,000...2,874,991
Ensembl chr20:2,862,000...2,874,948

G

diaphanous-related formin 3

decreases expression

Methamphetamine results in decreased expression of DIAPH3 mRNA

NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975

G

dicer 1 ribonuclease III

increases methylation

Methamphetamine results in increased methylation of DICER1 promoter

NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965

G

iodothyronine deiodinase 2

increases expression

Methamphetamine results in increased expression of DIO2 mRNA

NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809

G

divergent protein kinase domain 1A

decreases expression

Methamphetamine results in decreased expression of DIPK1A mRNA

NCBI chr14:1,772,412...1,843,508
Ensembl chr14:1,772,422...1,843,743

G

DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease

increases expression

Methamphetamine results in increased expression of DIS3 mRNA

NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642

G

DIS3-like exosome 3'-5' exoribonuclease

increases expression

Methamphetamine results in increased expression of DIS3L mRNA

NCBI chr 8:64,803,925...64,840,306
Ensembl chr 8:64,803,927...64,840,165

G

DIS3-like 3'-5' exoribonuclease 2

increases expression

Methamphetamine results in increased expression of DIS3L2 mRNA

NCBI chr 9:87,355,409...87,736,616
Ensembl chr 9:87,356,457...87,736,616

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

Methamphetamine results in increased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

dihydrolipoamide S-acetyltransferase

decreases expression

Methamphetamine results in decreased expression of DLAT protein

NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
Ensembl chr 1:50,978,051...51,004,479

G

dihydrolipoamide dehydrogenase

increases expression

Methamphetamine results in increased expression of DLD protein

NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795

G

discs large MAGUK scaffold protein 4

increases expression
multiple interactions

Methamphetamine results in increased expression of DLG4 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of DLG4 protein]

PMID:33421459 PMID:34461196

NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153

G

DLG associated protein 5

decreases expression

Methamphetamine results in decreased expression of DLGAP5 mRNA

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

dihydrolipoamide S-succinyltransferase

decreases expression
multiple interactions

Methamphetamine results in decreased expression of DLST mRNA; Methamphetamine results in decreased expression of DLST protein
Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of DLST mRNA]

PMID:19149911 PMID:19826936

NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296

G

dystrophin

increases expression

Methamphetamine results in increased expression of DMD mRNA

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

G

dermokine

increases expression
decreases expression

Methamphetamine results in increased expression of DMKN mRNA
Methamphetamine results in decreased expression of DMKN mRNA

PMID:19564919 PMID:32035215

NCBI chr 1:86,013,237...86,031,243
Ensembl chr 1:86,014,188...86,030,006

G

DM1 protein kinase

increases expression

Methamphetamine results in increased expression of DMPK mRNA

NCBI chr 1:78,730,255...78,740,585
Ensembl chr 1:78,730,275...78,740,593

G

DM1 locus, WD repeat containing

increases expression

Methamphetamine results in increased expression of DMWD mRNA

NCBI chr 1:78,722,436...78,729,224
Ensembl chr 1:78,722,330...78,740,593

G

dynein, axonemal, assembly factor 2

increases expression

Methamphetamine results in increased expression of DNAAF2 mRNA

NCBI chr 6:87,661,101...87,670,267
Ensembl chr 6:87,660,821...87,670,199

G

dynein, axonemal, heavy chain 1

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of DNAH1 mRNA
Methamphetamine results in decreased expression of DNAH1 mRNA

NCBI chr16:6,455,514...6,517,103
Ensembl chr16:6,456,002...6,518,350

G

dynein, axonemal, heavy chain 6

affects expression

Methamphetamine affects the expression of DNAH6 mRNA

NCBI chr 4:105,064,123...105,284,361
Ensembl chr 4:105,064,125...105,284,376

G

dynein, axonemal, intermediate chain 1

increases expression

Methamphetamine results in increased expression of DNAI1 mRNA

NCBI chr 5:56,730,179...56,800,926
Ensembl chr 5:56,730,179...56,800,925

G

DnaJ heat shock protein family (Hsp40) member A1

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of DNAJA1 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DNAJA1 mRNA]

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

DnaJ heat shock protein family (Hsp40) member A4

increases expression

Methamphetamine results in increased expression of DNAJA4 mRNA

NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207

G

DnaJ heat shock protein family (Hsp40) member B1

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of DNAJB1 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DNAJB1 mRNA]

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B4

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of DNAJB4 mRNA
Methamphetamine results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member B5

increases expression
multiple interactions

Methamphetamine results in increased expression of DNAJB5 mRNA
SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DNAJB5 mRNA]

PMID:19564919 PMID:36914120

NCBI chr 5:57,176,840...57,186,067
Ensembl chr 5:57,176,845...57,185,490

G

DnaJ heat shock protein family (Hsp40) member C3

increases expression
multiple interactions

Methamphetamine results in increased expression of DNAJC3 mRNA
SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DNAJC3 mRNA]

NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181

G

dynein, axonemal, light chain 4

decreases expression

Methamphetamine results in decreased expression of DNAL4 mRNA

NCBI chr 7:111,312,424...111,325,283
Ensembl chr 7:111,312,427...111,325,283
Ensembl chr20:111,312,427...111,325,283

G

deoxyribonuclease 1

increases expression
decreases expression
multiple interactions

Methamphetamine results in increased expression of DNASE1 mRNA
Methamphetamine results in decreased expression of DNASE1 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of DNASE1 mRNA

PMID:19564919 PMID:26307267

NCBI chr10:11,498,930...11,505,151
Ensembl chr10:11,498,931...11,501,869

G

dynamin 1

increases expression

Methamphetamine results in increased expression of DNM1 mRNA

NCBI chr 3:15,604,782...15,648,654
Ensembl chr 3:15,604,784...15,648,538

G

DNA methyltransferase 1

decreases expression
increases expression

Methamphetamine results in decreased expression of DNMT1 mRNA
Methamphetamine results in increased expression of DNMT1 mRNA

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

dedicator of cytokinesis 6

increases expression

Methamphetamine results in increased expression of DOCK6 mRNA

NCBI chr 8:20,342,430...20,394,660
Ensembl chr 8:20,342,089...20,394,552

G

docking protein 3

increases expression
multiple interactions

Methamphetamine results in increased expression of DOK3 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of DOK3 mRNA

NCBI chr17:9,109,633...9,115,188
Ensembl chr17:9,109,597...9,115,188

G

dolichol kinase

decreases expression

Methamphetamine results in decreased expression of DOLK mRNA

NCBI chr 3:13,557,826...13,559,864
Ensembl chr 3:13,557,817...13,559,917

G

dihydropyrimidinase-like 2

affects expression

Methamphetamine affects the expression of DPYSL2 protein

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

dihydropyrimidinase-like 3

decreases expression

Methamphetamine results in decreased expression of DPYSL3 protein

NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157

G

dihydropyrimidinase-like 5

increases expression

Methamphetamine results in increased expression of DPYSL5 protein

NCBI chr 6:25,575,104...25,659,422
Ensembl chr 6:25,575,104...25,659,422

G

dopamine receptor D1

increases expression
decreases expression
multiple interactions
affects activity
increases response to substance

Methamphetamine results in increased expression of DRD1 protein
Methamphetamine results in decreased expression of DRD1 protein
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the activity of DRD1 protein]; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP1 mRNA]; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA]; [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methamphetamine; Methamphetamine inhibits the reaction [SCH 23390 binds to DRD1 protein]
DRD1 protein results in increased susceptibility to Methamphetamine
[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methamphetamine; bisphenol A promotes the reaction [DRD1 protein results in increased susceptibility to Methamphetamine]; DRD1 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; DRD1 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]

PMID:2891082 PMID:11126397 PMID:11701771 PMID:12617968 PMID:18363855 More...

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

increases response to substance
decreases expression
multiple interactions
increases activity
affects activity

DRD2 gene polymorphism results in increased susceptibility to Methamphetamine
Methamphetamine results in decreased expression of DRD2 protein
[Sulpiride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methamphetamine; DRD2 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; DRD2 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]
Methamphetamine results in increased activity of DRD2 protein
Methamphetamine affects the activity of DRD2 protein
DRD2 gene results in increased susceptibility to Methamphetamine
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the activity of DRD2 protein]; [Aripiprazole binds to and results in increased activity of DRD2 protein] which results in increased susceptibility to Methamphetamine; Methamphetamine inhibits the reaction [Sulpiride binds to DRD2 protein]

PMID:2891082 PMID:11126397 PMID:11729018 PMID:17327886 PMID:18363855 More...

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

decreases expression
increases activity

Methamphetamine results in decreased expression of DRD3 protein
Methamphetamine results in increased activity of DRD3 protein

PMID:19046384 PMID:19940168

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

dopamine receptor D4

affects response to substance
multiple interactions
increases response to substance

DRD4 gene polymorphism affects the susceptibility to Methamphetamine
[NRA 0160 binds to and results in decreased activity of DRD4 protein] which results in decreased susceptibility to Methamphetamine
DRD4 gene polymorphism results in increased susceptibility to Methamphetamine

PMID:10579464 PMID:15274053 PMID:19462300

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

desmoplakin

increases expression

Methamphetamine results in increased expression of DSP mRNA

NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800

G

dentin sialophosphoprotein

increases expression

Methamphetamine results in increased expression of DSPP mRNA

NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672

G

dystonin

increases expression

Methamphetamine results in increased expression of DST mRNA

NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615

G

denticleless E3 ubiquitin protein ligase homolog

decreases expression

Methamphetamine results in decreased expression of DTL mRNA

NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890

G

deltex E3 ubiquitin ligase 3

increases expression
increases methylation

Methamphetamine results in increased expression of DTX3 mRNA
Methamphetamine results in increased methylation of DTX3 promoter

NCBI chr 7:63,013,769...63,018,431
Ensembl chr 7:63,013,371...63,018,522

G

dual specificity phosphatase 1

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of DUSP1 mRNA; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP1 mRNA]

PMID:11701771 PMID:19564919 PMID:26307267

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 11

increases expression

Methamphetamine results in increased expression of DUSP11 mRNA

NCBI chr 4:118,367,673...118,385,183
Ensembl chr 4:118,368,053...118,385,181

G

dual specificity phosphatase 14

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of DUSP14 mRNA
Methamphetamine results in increased expression of DUSP14 mRNA

NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329

G

dual specificity phosphatase 5

increases expression

Methamphetamine results in increased expression of DUSP5 mRNA

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

dual specificity phosphatase 6

multiple interactions
increases expression

[SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA]; Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA]

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

deoxyuridine triphosphatase

increases expression

Methamphetamine results in increased expression of DUT mRNA

NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771

G

double homeobox 4

decreases expression

Methamphetamine results in decreased expression of DUXBL1 mRNA

NCBI chr16:1,558,430...1,570,045
Ensembl chr16:1,558,766...1,568,565

G

DPY30 domain containing 2

increases expression

Methamphetamine results in increased expression of DYDC2 mRNA

NCBI chr16:16,928,172...16,941,950
Ensembl chr16:16,928,194...16,936,164

G

dysferlin

increases expression

Methamphetamine results in increased expression of DYSF mRNA

NCBI chr 4:116,490,877...116,690,709
Ensembl chr 4:116,490,616...116,690,709

G

Epstein-Barr virus induced 3

decreases expression

Methamphetamine results in decreased expression of EBI3 mRNA

NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544

G

enoyl CoA hydratase domain containing 2

increases expression

Methamphetamine results in increased expression of ECHDC2 mRNA

NCBI chr 5:122,915,874...122,934,860
Ensembl chr 5:122,916,134...122,934,859

G

enoyl CoA hydratase domain containing 3

decreases expression

Methamphetamine results in decreased expression of ECHDC3 mRNA

NCBI chr17:72,070,697...72,093,519
Ensembl chr17:72,070,668...72,093,516

G

epithelial cell transforming 2

decreases expression

Methamphetamine results in decreased expression of ECT2 mRNA

NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911

G

enhancer of mRNA decapping 4

increases expression

Methamphetamine results in increased expression of EDC4 mRNA

NCBI chr19:33,774,062...33,786,054
Ensembl chr19:33,774,055...33,787,758

G

endothelin 3

multiple interactions
increases expression

GATA4 protein affects the reaction [Methamphetamine results in increased expression of EDN3 mRNA]

NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093

G

eukaryotic elongation factor-2 kinase

decreases methylation

Methamphetamine results in decreased methylation of EEF2K promoter

NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164

G

ephrin B1

increases expression

Methamphetamine results in increased expression of EFNB1 mRNA

NCBI chr X:64,257,351...64,270,158
Ensembl chr X:64,257,351...64,270,157

G

EGF-like-domain, multiple 7

multiple interactions
increases expression
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of EGFL7 mRNA
Methamphetamine results in increased expression of EGFL7 mRNA
Methamphetamine results in decreased expression of EGFL7 mRNA

PMID:19564919 PMID:26307267

NCBI chr 3:9,404,622...9,416,879
Ensembl chr 3:9,407,520...9,416,879

G

EGF-like, fibronectin type III and laminin G domains

decreases expression
multiple interactions

Methamphetamine results in decreased expression of EGFLAM mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of EGFLAM mRNA

NCBI chr 2:56,301,945...56,476,665
Ensembl chr 2:56,302,566...56,476,298

G

egl-9 family hypoxia-inducible factor 3

increases expression

Methamphetamine results in increased expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

early growth response 1

multiple interactions
increases expression

CTAP octapeptide inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]
Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]; OPRM1 protein inhibits the reaction [Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]]

PMID:11754491 PMID:15644446 PMID:19564919 PMID:20184921 PMID:20298714

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

increases expression

Methamphetamine results in increased expression of EGR2 mRNA

PMID:15644446 PMID:19564919

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

early growth response 4

increases expression
multiple interactions

Methamphetamine results in increased expression of EGR4 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of EGR4 mRNA

NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328

G

EH domain binding protein 1-like 1

increases expression

Methamphetamine results in increased expression of EHBP1L1 mRNA

NCBI chr 1:202,994,115...203,014,320
Ensembl chr 1:202,994,118...203,014,270

G

euchromatic histone lysine methyltransferase 2

increases expression

Methamphetamine results in increased expression of EHMT2 mRNA

NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547

G

eukaryotic translation initiation factor 1A

increases expression

Methamphetamine results in increased expression of EIF1A mRNA

NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases phosphorylation
increases expression

CDK5 protein affects the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of EIF2AK3 protein modified form]
CDK5 protein affects the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein]; EIF2AK3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; EIF2AK3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]; EIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of ATF4 protein]; EIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; EIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]; Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein]; norbinaltorphimine inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein]

PMID:27323860 PMID:28070110 PMID:29705343

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation
multiple interactions

Methamphetamine results in increased phosphorylation of EIF2S1 protein
4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2S1 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2S1 protein]

PMID:28070110 PMID:34214594

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

Methamphetamine inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 4, gamma 2

increases expression

Methamphetamine results in increased expression of EIF4G2 mRNA

NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588

G

elongator acetyltransferase complex subunit 1

increases expression

Methamphetamine results in increased expression of ELP1 mRNA

NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762

G

EMAP like 1

increases expression

Methamphetamine results in increased expression of EML1 mRNA

NCBI chr 6:127,283,968...127,457,246
Ensembl chr 6:127,284,029...127,457,246

G

EMAP like 2

increases expression

Methamphetamine results in increased expression of EML2 mRNA

NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341

G

EMSY transcriptional repressor, BRCA2 interacting

increases expression

Methamphetamine results in increased expression of EMSY mRNA

NCBI chr 1:152,881,485...152,960,420
Ensembl chr 1:152,883,992...152,953,528

G

enolase 1

decreases expression

Methamphetamine results in decreased expression of ENO1 protein

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

enolase 2

increases expression

Methamphetamine results in increased expression of ENO2 protein

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

decreases expression

Methamphetamine results in decreased expression of ENPP1 mRNA

NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715

G

ectonucleotide pyrophosphatase/phosphodiesterase 6

decreases expression

Methamphetamine results in decreased expression of ENPP6 mRNA

NCBI chr16:45,165,883...45,294,126
Ensembl chr16:45,169,178...45,294,077

G

E1A binding protein p400

increases expression

Methamphetamine results in increased expression of EP400 mRNA

NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861

G

endothelial PAS domain protein 1

increases expression

Methamphetamine results in increased expression of EPAS1 mRNA

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

erythrocyte membrane protein band 4.1-like 1

decreases methylation

Methamphetamine results in decreased methylation of EPB41L1 promoter

NCBI chr 3:144,929,195...145,052,723
Ensembl chr 3:144,984,640...145,052,721

G

epithelial cell adhesion molecule

decreases expression
multiple interactions

Methamphetamine results in decreased expression of EPCAM mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of EPCAM mRNA

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

epoxide hydrolase 1

increases expression
multiple interactions
increases methylation

Methamphetamine results in increased expression of EPHX1 mRNA; Methamphetamine results in increased expression of EPHX1 protein
EPHX1 protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; EPHX1 protein affects the reaction [Methamphetamine results in decreased expression of BCL2L1 protein]; EPHX1 protein affects the reaction [Methamphetamine results in decreased expression of TH protein]; EPHX1 protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; Methamphetamine promotes the reaction [PRKCD protein modified form binds to EPHX1 protein]; PRKCD protein affects the reaction [Methamphetamine results in increased expression of EPHX1 protein]
Methamphetamine results in increased methylation of EPHX1 promoter

PMID:26307267 PMID:31422080

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

erythropoietin receptor

decreases expression

Methamphetamine results in decreased expression of EPOR mRNA

NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257

G

endoplasmic reticulum to nucleus signaling 1

increases expression
increases phosphorylation
multiple interactions

Methamphetamine results in increased expression of ERN1 protein modified form
Methamphetamine results in increased phosphorylation of ERN1 protein
ERN1 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; ERN1 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]; ERN1 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; ERN1 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]; ERN1 protein affects the reaction [Methamphetamine results in increased phosphorylation of NFKBIA protein]; Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of ERN1 protein]; norbinaltorphimine inhibits the reaction [Methamphetamine results in increased phosphorylation of ERN1 protein]
Melatonin inhibits the reaction [Methamphetamine results in increased expression of ERN1 protein modified form]

PMID:27323860 PMID:28070110

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

ERBB receptor feedback inhibitor 1

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of ERRFI1 mRNA
Methamphetamine results in increased expression of ERRFI1 mRNA

NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282

G

estrogen receptor 1

increases response to substance

ESR1 gene polymorphism results in increased susceptibility to Methamphetamine

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

enhancer trap locus 4

increases expression

Methamphetamine results in increased expression of ETL4 mRNA

NCBI chr17:82,841,075...83,304,868
Ensembl chr17:82,495,041...83,304,715

G

EvC ciliary complex subunit 2

increases expression

Methamphetamine results in increased expression of EVC2 mRNA

NCBI chr14:73,366,832...73,454,539
Ensembl chr14:73,367,963...73,454,516

G

exocyst complex component 7

decreases expression

Methamphetamine results in decreased expression of EXOC7 mRNA

NCBI chr10:101,521,630...101,540,425
Ensembl chr10:101,520,927...101,540,561

G

F11 receptor

multiple interactions
increases expression

Luteolin inhibits the reaction [Methamphetamine results in increased expression of F11R mRNA]

NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402

G

coagulation factor II, thrombin

multiple interactions
decreases expression

linalool inhibits the reaction [Methamphetamine results in decreased expression of F2 protein]

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor III, tissue factor

increases methylation

Methamphetamine results in increased methylation of F3 promoter

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid amide hydrolase

multiple interactions
decreases expression

[Methamphetamine co-treated with SCH 23390] results in decreased expression of FAAH mRNA
Methamphetamine results in decreased expression of FAAH mRNA

NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677

G

fatty acid binding protein 3

affects response to substance
increases expression

FABP3 affects the susceptibility to Methamphetamine
Methamphetamine results in increased expression of FABP3 mRNA

PMID:20181611 PMID:25290377

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

fatty acid binding protein 7

affects expression

Methamphetamine affects the expression of FABP7 protein

NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880

G

fumarylacetoacetate hydrolase

decreases expression

Methamphetamine results in decreased expression of FAH mRNA

NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505

G

family with sequence similarity 110, member A

decreases expression

Methamphetamine results in decreased expression of FAM110A mRNA

NCBI chr 3:140,474,484...140,485,074
Ensembl chr 3:140,474,249...140,485,093

G

family with sequence similarity 193, member A

increases expression

Methamphetamine results in increased expression of FAM193A mRNA

NCBI chr14:76,250,103...76,382,525
Ensembl chr14:76,256,161...76,382,514

G

family with sequence similarity 193, member B

increases expression

Methamphetamine results in increased expression of FAM193B mRNA

NCBI chr17:9,066,818...9,099,511
Ensembl chr17:9,066,707...9,099,508

G

fibronectin type III and ankyrin repeat domains 1

decreases expression

Methamphetamine results in decreased expression of FANK1 mRNA

NCBI chr 1:188,577,512...188,685,501
Ensembl chr 1:188,577,575...188,685,504

G

Fas cell surface death receptor

decreases expression
increases expression

Methamphetamine results in decreased expression of FAS mRNA
Methamphetamine results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

Methamphetamine results in increased expression of FASLG mRNA; Methamphetamine results in increased expression of FASLG protein

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

FAST kinase domains 3

decreases expression

Methamphetamine results in decreased expression of FASTKD3 mRNA

NCBI chr 1:34,858,342...34,866,988
Ensembl chr 1:34,858,219...34,866,973

G

filamin binding LIM protein 1

increases expression

Methamphetamine results in increased expression of FBLIM1 mRNA

NCBI chr 5:153,883,945...153,915,524
Ensembl chr 5:153,883,960...153,913,757

G

F-box and leucine-rich repeat protein 4

decreases expression

Methamphetamine results in decreased expression of FBXL4 mRNA

NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443

G

F-box protein 28

increases expression

Methamphetamine results in increased expression of FBXO28 mRNA

NCBI chr13:93,995,993...94,021,464
Ensembl chr13:93,995,996...94,021,464

G

F-box protein 32

increases expression

Methamphetamine results in increased expression of FBXO32 mRNA

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

F-box protein 33

increases expression

Methamphetamine results in increased expression of FBXO33 mRNA

NCBI chr 6:76,900,619...76,934,232
Ensembl chr 6:76,900,631...76,932,669

G

Fc gamma binding protein

decreases expression

Methamphetamine results in decreased expression of FCGBP mRNA

NCBI chr 1:83,374,979...83,413,082
Ensembl chr 1:83,372,127...83,413,083

G

fibroblast growth factor 2

increases expression

Methamphetamine results in increased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 4

multiple interactions
increases expression

[Methamphetamine co-treated with SCH 23390] results in increased expression of FGF4 mRNA
Methamphetamine results in increased expression of FGF4 mRNA

NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466

G

fibroblast growth factor receptor 3

increases expression

Methamphetamine results in increased expression of FGFR3 mRNA

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

fragile histidine triad diadenosine triphosphatase

affects response to substance

FHIT gene SNP affects the susceptibility to Methamphetamine

NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340

G

four-jointed box kinase 1

decreases expression

Methamphetamine results in decreased expression of FJX1 mRNA

NCBI chr 3:88,774,220...88,776,321
Ensembl chr 3:88,774,220...88,776,321

G

FKBP prolyl isomerase family member 15

affects response to substance

FKBP15 gene SNP affects the susceptibility to Methamphetamine

NCBI chr 5:75,750,786...75,815,038
Ensembl chr 5:75,750,787...75,814,990

G

FKBP prolyl isomerase 4

increases expression

Methamphetamine results in increased expression of FKBP4 mRNA

NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833

G

filamin A

increases expression

Methamphetamine results in increased expression of FLNA mRNA

NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052

G

filamin B

increases expression

Methamphetamine results in increased expression of FLNB mRNA

NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006

G

filamin C

increases expression

Methamphetamine results in increased expression of FLNC mRNA

PMID:26307267 PMID:36914120

NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844

G

Fms related receptor tyrosine kinase 1

increases expression

Methamphetamine results in increased expression of FLT1 mRNA

PMID:26307267 PMID:32035215

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

flavin containing dimethylaniline monoxygenase 2

increases expression
multiple interactions

Methamphetamine results in increased expression of FMO2 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of FMO2 mRNA

NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308

G

flavin containing dimethylaniline monoxygenase 3

increases metabolic processing

FMO3 protein results in increased metabolism of Methamphetamine

NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028

G

fibronectin 1

increases expression

Methamphetamine results in increased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
affects response to substance

Bee Venoms promotes the reaction [Methamphetamine results in increased expression of FOS protein]; FOS protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]; Idazoxan inhibits the reaction [Bee Venoms promotes the reaction [Methamphetamine results in increased expression of FOS protein]]; Lidocaine inhibits the reaction [Bee Venoms promotes the reaction [Methamphetamine results in increased expression of FOS protein]]
Methamphetamine results in increased expression of FOS mRNA; Methamphetamine results in increased expression of FOS protein
[Methamphetamine co-treated with SCH 23390] results in increased expression of FOS mRNA; Carbamazepine inhibits the reaction [Methamphetamine results in increased expression of FOS protein]; Oxytocin inhibits the reaction [Methamphetamine results in increased expression of FOS protein]
Methamphetamine results in increased expression of FOS; Methamphetamine results in increased expression of FOS protein
FOS mRNA affects the susceptibility to Methamphetamine; FOS protein affects the susceptibility to Methamphetamine

PMID:10559418 PMID:10731628 PMID:11754491 PMID:12050851 PMID:19564919 More...

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

methamphetamine increases expression of Fosb protein in the ventral tegmental area and nucleus accumbens

RGD

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

increases expression

Methamphetamine results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box E1

increases expression

Methamphetamine results in increased expression of FOXE1 mRNA; Methamphetamine results in increased expression of FOXE1 protein

NCBI chr 5:60,630,027...60,632,835
Ensembl chr 5:60,630,027...60,632,835

G

forkhead box O3

decreases phosphorylation
increases phosphorylation
multiple interactions
affects localization

Methamphetamine results in decreased phosphorylation of FOXO3 protein
Methamphetamine results in increased phosphorylation of FOXO3 protein
4-phenylbutyric acid inhibits the reaction [Methamphetamine results in decreased phosphorylation of FOXO3 protein]; DDIT3 protein affects the reaction [Methamphetamine results in decreased phosphorylation of FOXO3 protein]; Methamphetamine promotes the reaction [FOXO3 protein binds to DDIT3 protein]
Methamphetamine affects the localization of FOXO3 protein

PMID:34214594 PMID:35863504

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

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