4-hydroxynon-2-enal - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	4-hydroxynon-2-enal	go back to main search page
Accession:	CHEBI:32585	browse the term
Definition:	An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.
Synonyms:	related_synonym:	4-HNE; 4-Hydroxy-2,3-nonenal; 4-Hydroxy-2-nonenal; 4-Hydroxynonenal; Formula=C9H16O2; HNE; InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3; InChIKey=JVJFIQYAHPMBBX-UHFFFAOYSA-N; SMILES=[H]C(=CC=O)C(O)CCCCC
	xref:	CAS:29343-52-0; LINCS:LSM-4344
	xref_mesh:	MESH:C027576
	xref:	Wikipedia:4-Hydroxynonenal

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Genes (809)

4-hydroxynon-2-enal

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily C member 1

affects binding
increases expression
multiple interactions

4-hydroxy-2-nonenal binds to ABCC1 protein
4-hydroxy-2-nonenal results in increased expression of ABCC1 mRNA
[GSTM1 protein co-treated with ABCC1 protein] results in increased susceptibility to 4-hydroxy-2-nonenal

PMID:15672542 PMID:19191707 PMID:21925487

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

affects export
multiple interactions

ABCC2 protein affects the export of 4-hydroxy-2-nonenal metabolite
4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]

PMID:12623073 PMID:19326901

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

actin, alpha 1, skeletal muscle

affects binding

4-hydroxy-2-nonenal binds to ACTA1 protein

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin, beta

affects binding

ACTB protein binds to 4-hydroxy-2-nonenal

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actinin, alpha 1

affects binding

ACTN1 protein binds to 4-hydroxy-2-nonenal

NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251

G

actinin alpha 4

affects binding

ACTN4 protein binds to 4-hydroxy-2-nonenal

NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

increases expression

4-hydroxy-2-nonenal results in increased expression of ADH7 mRNA

NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182

G

acireductone dioxygenase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of ADI1 mRNA

NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842

G

adenosine A1 receptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ADORA1 mRNA

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2B receptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ADORA2B mRNA

NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772

G

adrenoceptor beta 2

increases expression

4-hydroxy-2-nonenal results in increased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

argonaute RISC catalytic component 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AGO2 mRNA

NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974

G

argonaute RISC catalytic component 3

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of AGO3 mRNA
4-hydroxy-2-nonenal results in increased expression of AGO3 mRNA

NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230

G

agrin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AGRN mRNA

NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003

G

angiotensinogen

affects binding
multiple interactions

4-hydroxy-2-nonenal binds to AGT protein modified form; AGT protein modified form binds to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal binds to and results in increased lipidation of AGT protein modified form; [AGT protein modified form results in increased chemical synthesis of Lipid Peroxides] which results in increased abundance of 4-hydroxy-2-nonenal; [Ascorbic Acid co-treated with Copper Sulfate] promotes the reaction [AGT protein modified form results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]; AGT protein modified form results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]

PMID:20977208 PMID:26111765 PMID:31144504

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

activator of HSP90 ATPase homolog 2

increases expression

4-hydroxy-2-nonenal results in increased expression of AHSA2 mRNA

NCBI chr14:97,476,304...97,485,725
Ensembl chr14:97,476,817...97,485,657

G

apoptosis inducing factor, mitochondria associated 1

increases expression

4-hydroxy-2-nonenal results in increased expression of AIFM1 mRNA

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AT-hook transcription factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AKNA mRNA

NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017

G

aldo-keto reductase family 1 member A1

increases reduction
increases expression

AKR1A1 protein results in increased reduction of 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of AKR1A1 mRNA

PMID:10510318 PMID:19191707

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

aldo-keto reductase family 1 member B1

affects reduction
increases reduction

AKR1B1 protein affects the reduction of 4-hydroxy-2-nonenal
AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal; AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal metabolite

PMID:9890881 PMID:10510318 PMID:11306073 PMID:21329684

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1 member B10

increases reduction
multiple interactions
increases metabolic processing

AKR1B10 protein results in increased reduction of 4-hydroxy-2-nonenal
Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-hydroxy-2-nonenal]

PMID:19013440 PMID:21329684 PMID:27417252

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C3

increases expression
increases response to substance
multiple interactions

4-hydroxy-2-nonenal results in increased expression of AKR1C3 mRNA; 4-hydroxy-2-nonenal results in increased expression of AKR1C3 protein
AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal
7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]

PMID:22964423 PMID:30849339

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

aldo-keto reductase family 7, member A2

decreases response to substance
affects response to substance
increases response to substance
multiple interactions
increases expression

AKR7A2 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
AKR7A2 protein affects the susceptibility to 4-hydroxy-2-nonenal
AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal
7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]; AKR7A2 protein affects the reaction [NFE2L2 protein affects the susceptibility to 4-hydroxy-2-nonenal]
4-hydroxy-2-nonenal results in increased expression of AKR7A2 mRNA; 4-hydroxy-2-nonenal results in increased expression of AKR7A2 protein

PMID:22001351 PMID:22964423 PMID:30849339

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

AKT serine/threonine kinase 1

affects response to substance
multiple interactions
increases activity
decreases phosphorylation

AKT1 protein affects the susceptibility to 4-hydroxy-2-nonenal
AKT1 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2 protein]
4-hydroxy-2-nonenal results in increased activity of AKT1 protein
4-hydroxy-2-nonenal results in decreased phosphorylation of AKT1 protein

PMID:18805481 PMID:23845594 PMID:24825450

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions

[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of RB1 protein modified form; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of TNF protein; [ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein]; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein]; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein]; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein]; sulforaphane inhibits the reaction [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

increases metabolic processing
multiple interactions
increases oxidation

ALDH1A1 protein results in increased metabolism of 4-hydroxy-2-nonenal
[APC protein mutant form results in increased expression of ALDH1A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
ALDH1A1 protein results in increased oxidation of 4-hydroxy-2-nonenal

PMID:21256123 PMID:21967605 PMID:22339434

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 2 family member

multiple interactions
increases oxidation

[APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
ALDH2 protein results in increased oxidation of 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal binds to and results in decreased activity of ALDH2 protein; ALDH2 protein inhibits the reaction [Rotenone results in increased abundance of 4-hydroxy-2-nonenal]

PMID:21967605 PMID:22339434 PMID:25263579

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 3 family, member A1

decreases response to substance
affects metabolic processing
affects response to substance
increases metabolic processing
multiple interactions
increases oxidation

ALDH3A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
ALDH3A1 protein affects the metabolism of 4-hydroxy-2-nonenal
ALDH3A1 protein affects the susceptibility to 4-hydroxy-2-nonenal
ALDH3A1 protein results in increased metabolism of 4-hydroxy-2-nonenal
[APC protein mutant form results in increased expression of ALDH3A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
ALDH3A1 protein results in increased oxidation of 4-hydroxy-2-nonenal

PMID:11018474 PMID:11306050 PMID:15905174 PMID:21256123 PMID:21967605 More...

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

aldehyde dehydrogenase 3 family, member B1

affects binding
decreases response to substance

4-hydroxy-2-nonenal binds to ALDH3B1 protein
ALDH3B1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal

NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921

G

aldehyde dehydrogenase 6 family, member A1

increases expression

4-hydroxy-2-nonenal results in increased expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

aldehyde dehydrogenase 7 family, member A1

increases metabolic processing
decreases response to substance

ALDH7A1 protein results in increased metabolism of 4-hydroxy-2-nonenal
ALDH7A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal

NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193

G

aldolase, fructose-bisphosphate A

affects binding

ALDOA protein binds to 4-hydroxy-2-nonenal

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

aldolase, fructose-bisphosphate C

multiple interactions

Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to ALDOA protein]

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

arachidonate 5-lipoxygenase

multiple interactions

ALOX5 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

arachidonate 5-lipoxygenase activating protein

increases expression

4-hydroxy-2-nonenal results in increased expression of ALOX5AP mRNA

NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986

G

alpha-kinase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ALPK1 mRNA

NCBI chr 2:216,126,939...216,247,180
Ensembl chr 2:216,128,825...216,247,157

G

alsin Rho guanine nucleotide exchange factor ALS2

increases expression

4-hydroxy-2-nonenal results in increased expression of ALS2 mRNA

NCBI chr 9:60,613,182...60,686,394
Ensembl chr 9:60,613,167...60,670,737

G

amphiphysin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AMPH mRNA

NCBI chr17:45,739,385...45,982,905
Ensembl chr17:45,739,395...45,983,315

G

anillin, actin binding protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ANLN mRNA

NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538

G

acidic nuclear phosphoprotein 32 family member A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ANP32A mRNA

NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443

G

acyloxyacyl hydrolase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AOAH mRNA

NCBI chr17:43,808,110...44,049,458
Ensembl chr17:43,809,638...44,049,148

G

aldehyde oxidase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

adaptor related protein complex 1 subunit sigma 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AP1S3 mRNA

NCBI chr 9:80,950,402...81,009,889
Ensembl chr 9:80,950,715...81,009,798

G

APC regulator of WNT signaling pathway

decreases expression
multiple interactions
affects response to substance
affects oxidation

4-hydroxy-2-nonenal results in decreased expression of APC mRNA
[APC protein affects the oxidation of 4-hydroxy-2-nonenal] which affects the abundance of 4-hydroxynonenoic acid; [APC protein mutant form results in increased expression of ALDH1A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of ALDH3A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of GSTA4 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of SLC7A11 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
APC protein affects the susceptibility to 4-hydroxy-2-nonenal

PMID:12419474 PMID:21967605

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases expression

4-hydroxy-2-nonenal results in increased expression of APEX1 mRNA

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A1

affects binding

4-hydroxy-2-nonenal binds to APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein D

decreases abundance

APOD protein results in decreased abundance of 4-hydroxy-2-nonenal

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

amyloid beta precursor protein

decreases expression
multiple interactions

4-hydroxy-2-nonenal results in decreased expression of APP mRNA
[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal; [APP protein modified form inhibits the reaction [[Copper co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide]] which results in increased chemical synthesis of 4-hydroxy-2-nonenal; Deferoxamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]

PMID:12419474 PMID:17964426

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

Rho GTPase activating protein 11A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ARHGAP11A mRNA

NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559

G

Rho GTPase activating protein 22

increases expression

4-hydroxy-2-nonenal results in increased expression of ARHGAP22 mRNA

NCBI chr16:8,473,806...8,631,552
Ensembl chr16:8,476,306...8,631,548

G

Rho GTPase activating protein 27

increases expression

4-hydroxy-2-nonenal results in increased expression of ARHGAP27 mRNA

NCBI chr10:88,280,470...88,313,225
Ensembl chr10:88,280,455...88,313,185

G

Rho GTPase activating protein 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ARHGAP5 mRNA

NCBI chr 6:69,975,904...70,039,299
Ensembl chr 6:69,976,214...70,037,660

G

Rho GDP dissociation inhibitor alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ARHGDIA mRNA

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

Rho guanine nucleotide exchange factor 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ARHGEF3 mRNA

NCBI chr16:2,301,573...2,581,951
Ensembl chr16:2,300,138...2,581,945

G

AT-rich interaction domain 5A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ARID5A mRNA

NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597

G

arrestin domain containing 3

increases expression

4-hydroxy-2-nonenal results in increased expression of ARRDC3 mRNA

NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978

G

anti-silencing function 1B histone chaperone

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of ASF1B mRNA
4-hydroxy-2-nonenal results in increased expression of ASF1B mRNA

NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549

G

assembly factor for spindle microtubules

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ASPM mRNA

NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755

G

ATPase family, AAA domain containing 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ATAD5 mRNA

NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845

G

activating transcription factor 3

increases expression

4-hydroxy-2-nonenal results in increased expression of ATF3 protein

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 4

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of ATF4 mRNA; 4-hydroxy-2-nonenal results in increased expression of ATF4 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF4 protein]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form]

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

autophagy related 5

increases expression

4-hydroxy-2-nonenal results in increased expression of ATG5 mRNA

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

autophagy related 7

increases expression

4-hydroxy-2-nonenal results in increased expression of ATG7 mRNA

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

ATM serine/threonine kinase

increases expression

4-hydroxy-2-nonenal results in increased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase Na+/K+ transporting subunit beta 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ATP1B3 mRNA

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598

G

ATP synthase F1 subunit alpha

affects binding

4-hydroxy-2-nonenal binds to ATP5F1A protein

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

ATPase H+ transporting V1 subunit A

increases expression

4-hydroxy-2-nonenal results in increased expression of ATP6V1A mRNA

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ATR serine/threonine kinase

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of ATR mRNA
4-hydroxy-2-nonenal results in increased expression of ATR mRNA

PMID:12419474 PMID:19191707

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

advillin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AVIL mRNA

NCBI chr 7:62,825,459...62,844,103
Ensembl chr 7:62,826,025...62,844,071

G

beta-2 microglobulin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of B2M mRNA

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

BRISC and BRCA1 A complex member 2

increases expression

4-hydroxy-2-nonenal results in increased expression of BABAM2 mRNA

NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951

G

BCL2-associated agonist of cell death

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of BAD mRNA
4-hydroxy-2-nonenal results in increased expression of BAD protein

PMID:12419474 PMID:24825450

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

basic leucine zipper ATF-like transcription factor 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BATF2 mRNA

NCBI chr 1:203,467,291...203,479,428
Ensembl chr 1:203,468,097...203,475,889

G

BCL2 associated X, apoptosis regulator

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of BAX mRNA
4-hydroxy-2-nonenal results in increased expression of BAX protein

PMID:12419474 PMID:15607904 PMID:21187080 PMID:24825450

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

multiple interactions
increases expression

4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA]

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BBX high mobility group box domain containing

increases expression

4-hydroxy-2-nonenal results in increased expression of BBX mRNA

NCBI chr11:50,381,249...50,628,934
Ensembl chr11:50,381,247...50,623,251

G

BCAR3 adaptor protein, NSP family member

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BCAR3 mRNA

NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798

G

BCL2-related protein A1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BCL2A1B mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BCL2L1 mRNA

PMID:12419474 PMID:19191707

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

Bcl2-like 11

increases expression

4-hydroxy-2-nonenal results in increased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

BCL3, transcription coactivator

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BCL3 mRNA

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BCL6, transcription repressor

increases expression

4-hydroxy-2-nonenal results in increased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

brain-derived neurotrophic factor

decreases expression
multiple interactions

4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA
CREBBP protein inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

biglycan

multiple interactions

[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenal

NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461

G

basic helix-loop-helix family, member e40

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

basic helix-loop-helix family, member e41

increases expression

4-hydroxy-2-nonenal results in increased expression of BHLHE41 mRNA

NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468

G

BH3 interacting domain death agonist

increases expression

4-hydroxy-2-nonenal results in increased expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 5

increases expression
decreases expression

4-hydroxy-2-nonenal results in increased expression of BIRC5 mRNA
4-hydroxy-2-nonenal results in decreased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BLM RecQ like helicase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BLM mRNA

NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312

G

biliverdin reductase B

increases expression

4-hydroxy-2-nonenal results in increased expression of BLVRB mRNA

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

bone morphogenetic protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BMP1 mRNA

NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776

G

BCL2 interacting protein 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

B-Raf proto-oncogene, serine/threonine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BRAF mRNA

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

BUB1 mitotic checkpoint serine/threonine kinase B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

basic leucine zipper and W2 domains 1

increases expression

4-hydroxy-2-nonenal results in increased expression of BZW1 mRNA

NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430

G

complement C5a receptor 1

increases expression

4-hydroxy-2-nonenal results in increased expression of C5AR1 mRNA

NCBI chr 1:76,948,622...76,959,826

G

calcium voltage-gated channel subunit alpha1 A

increases expression

4-hydroxy-2-nonenal results in increased expression of CACNA1A mRNA

NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225

G

calcium dependent secretion activator

increases expression

4-hydroxy-2-nonenal results in increased expression of CADPS mRNA

NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779

G

calcitonin-related polypeptide alpha

increases secretion

4-hydroxy-2-nonenal results in increased secretion of CALCA protein

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

calcium binding and coiled coil domain 1

increases expression

4-hydroxy-2-nonenal results in increased expression of CALCOCO1 mRNA

NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422

G

calreticulin 3

increases expression

4-hydroxy-2-nonenal results in increased expression of CALR3 mRNA

NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015

G

calcium/calmodulin-dependent protein kinase ID

increases expression

4-hydroxy-2-nonenal results in increased expression of CAMK1D mRNA

NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556

G

cyclase associated actin cytoskeleton regulatory protein 1

affects binding

CAP1 protein binds to 4-hydroxy-2-nonenal

NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769

G

calpain 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CAPN2 mRNA

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

calpain, small subunit 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CAPNS1 mRNA

NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795

G

capping actin protein of muscle Z-line subunit beta

affects binding

CAPZB protein binds to 4-hydroxy-2-nonenal

NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409

G

carbonic anhydrase 12

increases expression

4-hydroxy-2-nonenal results in increased expression of CAR12 mRNA

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

carbonic anhydrase 2

affects binding

CA2 protein binds to 4-hydroxy-2-nonenal

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

calcium regulated heat stable protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CARHSP1 mRNA

NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019

G

calcium/calmodulin dependent serine protein kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CASK mRNA

NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694

G

caspase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CASP1 mRNA

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases activity
increases cleavage

4-hydroxy-2-nonenal results in increased cleavage of and results in increased activity of CASP3 protein; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]
4-hydroxy-2-nonenal results in increased cleavage of CASP3 protein

PMID:11488593 PMID:16322078 PMID:16337876 PMID:17263905 PMID:19326901 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CASP4 mRNA

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 7

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CASP7 mRNA

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
multiple interactions

4-hydroxy-2-nonenal results in increased activity of CASP9 protein
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]

PMID:16322078 PMID:17263905 PMID:21187080 PMID:24825450

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases expression

4-hydroxy-2-nonenal results in increased expression of CAT mRNA

PMID:19191707 PMID:24423726

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Cbl proto-oncogene B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CBLB mRNA

NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839

G

C-C motif chemokine ligand 17

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of CCL17 mRNA
4-hydroxy-2-nonenal results in increased expression of CCL17 mRNA

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 22

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCL22 mRNA

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine ligand 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCL4 mRNA

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

multiple interactions
decreases expression

4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein]
4-hydroxy-2-nonenal results in decreased expression of CCL5 mRNA

PMID:19191707 PMID:19627980

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

C-C motif chemokine ligand 9

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCL6 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

cyclin A2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCNA2 mRNA

PMID:12419474 PMID:19191707

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of CCND1]
4-hydroxy-2-nonenal results in increased expression of CCND1; 4-hydroxy-2-nonenal results in increased expression of CCND1 mRNA

PMID:16328008 PMID:19191707

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCND2 protein

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin D3

multiple interactions

[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein]

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin F

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCNF mRNA

NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101

G

cyclin G1

increases expression

4-hydroxy-2-nonenal results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cyclin G2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCNG2 mRNA

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

cyclin K

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCNK mRNA

NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191

G

cyclin T1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCNT1 mRNA

NCBI chr 7:129,687,146...129,718,080
Ensembl chr 7:129,691,209...129,717,871

G

C-C motif chemokine receptor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCR1 mRNA

PMID:12419474 PMID:19191707

NCBI chr 8:123,556,286...123,561,841

G

CD14 molecule

increases expression

4-hydroxy-2-nonenal results in increased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

Cd300a molecule

increases expression

4-hydroxy-2-nonenal results in increased expression of CD300A mRNA

NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674

G

CD300 molecule-like family member b

increases expression

4-hydroxy-2-nonenal results in increased expression of CD300LB mRNA

NCBI chr10:99,964,801...99,974,790
Ensembl chr10:99,964,801...99,974,790

G

Cd300 molecule-like family member F

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CD300LF mRNA

NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041

G

CD36 molecule

increases expression

4-hydroxy-2-nonenal results in increased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD40 molecule

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CD40 mRNA

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD44 molecule

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CD44 mRNA

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

Cd47 molecule

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CD47 mRNA

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

CD83 molecule

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CD83 mRNA

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

G

CD86 molecule

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CD86 mRNA

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cell division cycle 20

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDC20 mRNA

PMID:12419474 PMID:19191707

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 25A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDC25A mRNA

PMID:12419474 PMID:19191707

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 25C

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle associated 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cadherin 1

multiple interactions

[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in decreased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDH2 mRNA

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cadherin 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDH3 mRNA

NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084

G

cyclin dependent kinase 2

multiple interactions

4-hydroxy-2-nonenal binds to and results in increased alkylation of and results in decreased activity of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 6

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of CDK6 mRNA
[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein]

PMID:19191707 PMID:33007382

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase 9

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDK9 mRNA

NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410

G

cyclin-dependent kinase inhibitor 1A

increases expression

4-hydroxy-2-nonenal results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1C

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDKN1C mRNA

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

cyclin dependent kinase inhibitor 2D

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDKN2D mRNA

PMID:12419474 PMID:19191707

NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674

G

CCAAT/enhancer binding protein alpha

increases expression

4-hydroxy-2-nonenal results in increased expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

centromere protein A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CENPA mRNA

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

G

centrosomal protein 290

increases expression

4-hydroxy-2-nonenal results in increased expression of CEP290 mRNA

NCBI chr 7:35,310,071...35,399,388
Ensembl chr 7:35,310,199...35,399,392

G

carboxylesterase 1D

decreases activity

4-hydroxy-2-nonenal results in decreased activity of CES1 protein

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 2H

increases activity

4-hydroxy-2-nonenal results in increased activity of CES2 protein

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

complement factor B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CFB mRNA

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

cofilin 1

affects binding

CFL1 protein binds to 4-hydroxy-2-nonenal

NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587

G

checkpoint kinase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

CHM like Rab escort protein

increases expression

4-hydroxy-2-nonenal results in increased expression of CHML mRNA

NCBI chr13:87,609,647...87,619,868
Ensembl chr13:87,589,298...87,619,862

G

ciliogenesis associated kinase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of CILK1 mRNA

NCBI chr 8:78,984,075...79,042,695
Ensembl chr 8:78,984,258...79,042,691

G

cytokine inducible SH2-containing protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

CDC28 protein kinase regulatory subunit 1B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CKS1B mRNA

NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636

G

CDC28 protein kinase regulatory subunit 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

claudin 11

increases expression

4-hydroxy-2-nonenal results in increased expression of CLDN11 mRNA

NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050

G

C-type lectin domain family 12, member A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CLEC12A mRNA

NCBI chr 4:162,798,125...162,816,757
Ensembl chr 4:162,798,125...162,816,753

G

C-type lectin domain family 4, member A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CLEC4N mRNA

NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402

G

C-type lectin domain family 4, member D

increases expression

4-hydroxy-2-nonenal results in increased expression of CLEC4D mRNA

NCBI chr 4:156,589,591...156,599,279
Ensembl chr 4:156,589,792...156,598,848

G

C-type lectin domain containing 5A

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of CLEC5A mRNA
4-hydroxy-2-nonenal results in increased expression of CLEC5A mRNA

NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859

G

CDC-like kinase 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CLK3 mRNA

NCBI chr 8:58,152,155...58,167,196
Ensembl chr 8:58,152,155...58,168,181

G

collagen type I alpha 1 chain

increases expression

4-hydroxy-2-nonenal results in increased expression of COL1A1 mRNA; 4-hydroxy-2-nonenal results in increased expression of COL1A1 protein

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

catechol-O-methyltransferase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of COMT mRNA

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

ceruloplasmin

decreases expression
affects abundance

4-hydroxy-2-nonenal results in decreased expression of CP mRNA
CP protein affects the abundance of 4-hydroxy-2-nonenal

PMID:12572680 PMID:19191707

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carboxypeptidase E

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CPE mRNA

NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233

G

cAMP responsive element binding protein 1

decreases expression
increases phosphorylation

4-hydroxy-2-nonenal results in decreased expression of CREB1 mRNA
4-hydroxy-2-nonenal results in increased phosphorylation of CREB1 protein

PMID:12419474 PMID:16337876

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

CREB binding protein

multiple interactions

CREBBP protein inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA]

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

cellular repressor of E1A-stimulated genes 1

increases expression

4-hydroxy-2-nonenal results in increased expression of CREG1 mRNA

NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308

G

carnitine O-octanoyltransferase

increases expression

4-hydroxy-2-nonenal results in increased expression of CROT mRNA

NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109

G

cryptochrome circadian regulator 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CRY1 mRNA

NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091

G

cryptochrome circadian regulator 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CRY2 mRNA

NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965

G

crystallin zeta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CRYZ mRNA

NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758

G

colony stimulating factor 1 receptor

increases expression

4-hydroxy-2-nonenal results in increased expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of CSF3 mRNA
4-hydroxy-2-nonenal results in increased expression of CSF3 mRNA; 4-hydroxy-2-nonenal results in increased expression of CSF3 protein

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

casein kinase 1, gamma 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CSNK1G2 mRNA

NCBI chr 7:9,076,739...9,095,082
Ensembl chr 7:9,076,740...9,095,052

G

cysteine and serine rich nuclear protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AXUD1 mRNA

NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183

G

catenin beta 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CTNNB1 mRNA; 4-hydroxy-2-nonenal results in decreased expression of CTNNB1 protein

PMID:12419474 PMID:24825450

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of CTSD mRNA]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of CTSD mRNA]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin L

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CTSL mRNA

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cortactin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CTTN mRNA

NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164

G

cut-like homeobox 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CUX1 mRNA

NCBI chr12:20,107,062...20,425,868
Ensembl chr12:20,107,311...20,425,866

G

C-X-C motif chemokine ligand 10

multiple interactions

4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 protein]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 14

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CXCL14 mRNA

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

C-X-C motif chemokine ligand 3

increases expression

4-hydroxy-2-nonenal results in increased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine receptor 4

increases expression

4-hydroxy-2-nonenal results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome b-245 beta chain

increases abundance

CYBB protein results in increased abundance of 4-hydroxy-2-nonenal

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome c, somatic

affects localization
multiple interactions

4-hydroxy-2-nonenal affects the localization of CYCS protein
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]

PMID:16322078 PMID:17263905 PMID:21187080

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[CYP1A2 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP1A2 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

[CYP2B6 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2B6 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2B6 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

[CYP2C29 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2C29 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2C29 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily j, polypeptide 4

multiple interactions

[CYP2J2 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2J2 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2J2 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; [CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal; [CYP3A4 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cysteinyl leukotriene receptor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CYSLTR1 mRNA

NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121

G

cytohesin 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CYTH4 mRNA

NCBI chr 7:110,152,232...110,176,726
Ensembl chr 7:110,152,272...110,176,741

G

death-associated protein

increases expression

4-hydroxy-2-nonenal results in increased expression of DAP mRNA

NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752

G

death associated protein kinase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DAPK1 mRNA

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

DBF4-CDC7 kinase regulatory subunit

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DBF4 mRNA

NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066

G

decorin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of DDIT3 mRNA; 4-hydroxy-2-nonenal results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of DDIT3 mRNA]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

discoidin domain receptor tyrosine kinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DDR2 mRNA

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

density regulated reinitiation and release factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DENR mRNA

NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843

G

DNA fragmentation factor subunit alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DFFA mRNA

NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633

G

DNA fragmentation factor subunit beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DFFB mRNA

NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628

G

diacylglycerol kinase, eta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DGKH mRNA

NCBI chr15:53,981,079...54,150,470
Ensembl chr15:53,991,481...54,150,706

G

DEXH-box helicase 58

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DHX58 mRNA

NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525

G

iodothyronine deiodinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DIO2 mRNA

NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809

G

DLG associated protein 5

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of DLGAP5 mRNA
4-hydroxy-2-nonenal results in increased expression of DLGAP5 mRNA

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

4-hydroxy-2-nonenal results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member C3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DNAJC3 mRNA

NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181

G

deoxyribonuclease 2, lysosomal

increases expression

4-hydroxy-2-nonenal results in increased expression of DNASE2A mRNA

NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376

G

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DNPH1 mRNA

NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022

G

dihydropyrimidinase-like 2

affects binding

4-hydroxy-2-nonenal binds to DPYSL2 protein

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

dopamine receptor D2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dystonin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DST mRNA

NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615

G

dynein light chain Tctex-type 3

affects binding

DYNLT3 protein binds to 4-hydroxy-2-nonenal

NCBI chr X:13,327,933...13,337,139
Ensembl chr X:13,327,892...13,337,139

G

E2F transcription factor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 2

increases expression

4-hydroxy-2-nonenal results in increased expression of E2F2 mRNA

NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217

G

E2F transcription factor 8

decreases expression

4-hydroxy-2-nonenal results in decreased expression of E2F8 mRNA

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

enoyl CoA hydratase domain containing 3

increases expression

4-hydroxy-2-nonenal results in increased expression of ECHDC3 mRNA

NCBI chr17:72,070,697...72,093,519
Ensembl chr17:72,070,668...72,093,516

G

endothelin 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic translation elongation factor 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EEF2 protein

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

ephrin A4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EFNA4 mRNA

NCBI chr 2:174,748,729...174,752,979
Ensembl chr 2:174,748,724...174,752,979

G

EP300 interacting inhibitor of differentiation 3

increases expression

4-hydroxy-2-nonenal results in increased expression of EID3 mRNA

NCBI chr 7:20,860,073...20,861,395

G

eukaryotic translation initiation factor 2A

increases phosphorylation

4-hydroxy-2-nonenal results in increased phosphorylation of EIF2A protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2-alpha kinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EIF2AK2 mRNA

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

4-hydroxy-2-nonenal results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of EIF2S1 protein]

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 4E

increases expression

4-hydroxy-2-nonenal results in increased expression of EIF4E mRNA

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E family member 2

increases expression

4-hydroxy-2-nonenal results in increased expression of EIF4E2 mRNA

NCBI chr 9:87,886,126...87,914,470
Ensembl chr 9:87,878,085...87,914,482

G

eukaryotic translation initiation factor 4E binding protein 1

increases phosphorylation

4-hydroxy-2-nonenal results in increased phosphorylation of EIF4EBP1 protein

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 5A

increases expression

4-hydroxy-2-nonenal results in increased expression of EIF5A mRNA

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

ETS transcription factor ELK1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ELK1 mRNA

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

elongin C

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ELOC mRNA

NCBI chr 5:2,661,527...2,677,893
Ensembl chr 5:2,661,724...2,677,890

G

elongator acetyltransferase complex subunit 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ELP1 mRNA

NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762

G

essential meiotic structure-specific endonuclease 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EME1 mRNA

NCBI chr10:79,586,718...79,595,515
Ensembl chr10:79,586,729...79,595,435

G

enolase 1

affects binding

4-hydroxy-2-nonenal binds to ENO1 protein

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

epoxide hydrolase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

epidermal growth factor receptor pathway substrate 15

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EPS15 mRNA

NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221

G

EGFR pathway substrate 8, signaling adaptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EPS8 mRNA

NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873

G

epithelial stromal interaction 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EPSTI1 mRNA

NCBI chr15:53,283,964...53,382,192
Ensembl chr15:53,284,216...53,382,191

G

erb-b2 receptor tyrosine kinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERBB2 mRNA

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERBB4 mRNA

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

ERCC excision repair 1, endonuclease non-catalytic subunit

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERCC1 mRNA

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 2, TFIIH core complex helicase subunit

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERCC2 mRNA

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

ERCC excision repair 5, endonuclease

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERCC5 mRNA

NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERCC6L mRNA

NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756

G

endoplasmic reticulum to nucleus signaling 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERN1 mRNA

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

extra spindle pole bodies like 1, separase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ESPL1 mRNA

NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984

G

ETS proto-oncogene 1, transcription factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

ETS proto-oncogene 2, transcription factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ETS2 mRNA

NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319

G

ETS variant transcription factor 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ETV3 mRNA

NCBI chr 2:172,965,461...172,980,320
Ensembl chr 2:172,965,588...172,980,314

G

ETS variant transcription factor 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ETV6 mRNA

NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992

G

ezrin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EZR mRNA

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

coagulation factor X

increases expression

4-hydroxy-2-nonenal results in increased expression of F10 mRNA

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

G

coagulation factor II (thrombin) receptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of F2R mRNA

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

G

coagulation factor III, tissue factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of F3 mRNA

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

FA complementation group D2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FANCD2 mRNA

NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412

G

Fas-activated serine/threonine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FASTK mRNA

NCBI chr 4:10,732,273...10,736,332
Ensembl chr 4:10,732,256...10,737,430

G

F-box and leucine-rich repeat protein 17

increases expression

4-hydroxy-2-nonenal results in increased expression of FBXL17 mRNA

NCBI chr 9:102,780,573...103,206,978
Ensembl chr 9:102,782,440...103,208,950

G

F-box and leucine-rich repeat protein 20

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of FBXL20 mRNA
4-hydroxy-2-nonenal results in increased expression of FBXL20 mRNA

NCBI chr10:83,080,568...83,143,680
Ensembl chr10:83,086,551...83,144,162

G

F-box protein 15

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FBXO15 mRNA

NCBI chr18:78,319,577...78,634,695
Ensembl chr18:78,319,534...78,390,765

G

F-box protein 22

increases expression

4-hydroxy-2-nonenal results in increased expression of FBXO22 mRNA

NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148

G

F-box protein 30

increases expression

4-hydroxy-2-nonenal results in increased expression of FBXO30 mRNA

NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441

G

F-box protein 31

increases expression

4-hydroxy-2-nonenal results in increased expression of FBXO31 mRNA

NCBI chr19:49,624,813...49,656,052
Ensembl chr19:49,627,686...49,656,010

G

F-box protein 39

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FBXO39 mRNA

NCBI chr10:56,929,699...56,934,911
Ensembl chr10:56,932,297...56,934,906

G

F-box protein 5

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of FBXO5 mRNA
4-hydroxy-2-nonenal results in increased expression of FBXO5 mRNA

NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437

G

Fc gamma receptor 1A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FCGR1 mRNA; 4-hydroxy-2-nonenal results in decreased expression of FCGR1A mRNA

NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994

G

Fc gamma receptor 2B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FCGR2B mRNA

NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778

G

ferrochelatase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FECH mRNA

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

G

fem-1 homolog C

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FEM1C mRNA

NCBI chr18:39,232,900...39,258,692
Ensembl chr18:39,232,900...39,258,692

G

flap structure-specific endonuclease 1

increases expression
decreases expression

4-hydroxy-2-nonenal results in increased expression of FEN1 mRNA
4-hydroxy-2-nonenal results in decreased expression of FEN1 mRNA

NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003

G

Fibroblast growth factor receptor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FGFR1 mRNA

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

FGR proto-oncogene, Src family tyrosine kinase

increases expression
decreases expression

4-hydroxy-2-nonenal results in increased expression of FGR mRNA
4-hydroxy-2-nonenal results in decreased expression of FGR mRNA

NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326

G

FKBP prolyl isomerase 14

increases expression

4-hydroxy-2-nonenal results in increased expression of FKBP14 mRNA

NCBI chr 4:83,705,531...83,721,515
Ensembl chr 4:83,705,652...83,721,528

G

FKBP prolyl isomerase like

increases expression

4-hydroxy-2-nonenal results in increased expression of FKBPL mRNA

NCBI chr20:4,099,845...4,101,315
Ensembl chr20:4,099,806...4,101,368

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

4-hydroxy-2-nonenal results in decreased expression of FOS mRNA
4-hydroxy-2-nonenal results in decreased expression of FOS protein
resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of FOS protein]
4-hydroxy-2-nonenal promotes the reaction [FOS protein binds to GGT1 promoter]

PMID:12419474 PMID:16195535 PMID:16322078

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

4-hydroxy-2-nonenal promotes the reaction [FOSB protein binds to GGT1 promoter]

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions

4-hydroxy-2-nonenal promotes the reaction [FOSL1 protein binds to GGT1 promoter]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]

PMID:9890986 PMID:16195535

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

FOS like 2, AP-1 transcription factor subunit

multiple interactions

4-hydroxy-2-nonenal promotes the reaction [FOSL2 protein binds to GGT1 promoter]

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box M1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FOXM1 mRNA

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

forkhead box O3

multiple interactions

FOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]]

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

forkhead box P1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FOXP1 mRNA

NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258

G

formyl peptide receptor 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FPR3 mRNA

NCBI chr 1:58,884,427...58,893,472
Ensembl chr 1:58,845,118...58,893,467

G

far upstream element binding protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FUBP1 mRNA

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

frataxin

multiple interactions

4-hydroxy-2-nonenal affects the reaction [Ethanol affects the expression of FXN protein]

NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540

G

glucose-6-phosphate dehydrogenase

increases expression

4-hydroxy-2-nonenal results in increased expression of G6PDX mRNA

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GABA type A receptor associated protein like 1

increases expression

4-hydroxy-2-nonenal results in increased expression of GABARAPL1 mRNA

NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450

G

growth arrest and DNA-damage-inducible, alpha

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA]

PMID:19191707 PMID:24291486

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

cyclin G associated kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GAK mRNA

NCBI chr14:1,089,853...1,164,098
Ensembl chr14:1,089,866...1,216,398

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

[Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]] which results in decreased activity of GAPDH protein; [Hydroxyurea results in increased abundance of Free Radicals] promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]

PMID:20889679 PMID:23696560

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

GATA binding protein 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GATA3 mRNA

PMID:12419474 PMID:19191707

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

GATA zinc finger domain containing 2B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GATAD2B mRNA

NCBI chr 2:175,748,594...175,829,837
Ensembl chr 2:175,749,433...175,825,542

G

glutamyl-tRNA amidotransferase subunit B

increases expression

4-hydroxy-2-nonenal results in increased expression of GATB mRNA

NCBI chr 2:170,930,547...171,017,133
Ensembl chr 2:170,930,542...171,016,695

G

guanylate binding protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

guanylate binding protein 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GBP3 mRNA

NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879

G

guanylate binding protein 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GBP5 mRNA

NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of GCLC mRNA
4-hydroxy-2-nonenal results in increased expression of GCLC protein
NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA]

PMID:19191707 PMID:24291486

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

4-hydroxy-2-nonenal results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

GEN1 Holliday junction 5' flap endonuclease

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GEN1 mRNA

NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401

G

gametogenetin binding protein 1

increases expression

4-hydroxy-2-nonenal results in increased expression of GGNBP1 mRNA

NCBI chr20:5,109,849...5,116,185
Ensembl chr20:5,099,311...5,116,183

G

gamma-glutamyltransferase 1

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GGT1 mRNA]; 4-hydroxy-2-nonenal promotes the reaction [FOS protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [FOSB protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [FOSL1 protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [FOSL2 protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [JUN protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [JUNB protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [NFE2L1 protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [NFE2L2 protein binds to GGT1 promoter]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GGT1 mRNA]

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

G protein subunit alpha 13

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GNA13 mRNA

NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774

G

G protein subunit alpha q

increases expression

4-hydroxy-2-nonenal results in increased expression of GNAQ mRNA

NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672

G

GNAS complex locus

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GNAS mRNA

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein subunit alpha transducin 3

increases expression

4-hydroxy-2-nonenal results in increased expression of GNAT3 mRNA

NCBI chr 4:17,162,500...17,212,283
Ensembl chr 4:17,162,490...17,212,283

G

G protein subunit beta 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GNB1 mRNA

NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124

G

G protein subunit beta 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GNB2 mRNA

NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019

G

glutamic-oxaloacetic transaminase 2

multiple interactions

Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GOT2 protein]

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

G protein-coupled receptor 183

increases expression

4-hydroxy-2-nonenal results in increased expression of GPR183 mRNA

NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559

G

glutathione peroxidase 1

increases abundance

GPX1 gene mutant form results in increased abundance of 4-hydroxy-2-nonenal

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glycogen synthase kinase 3 beta

decreases expression
decreases phosphorylation

4-hydroxy-2-nonenal results in decreased expression of GSK3B mRNA
4-hydroxy-2-nonenal results in decreased phosphorylation of GSK3B protein

PMID:12419474 PMID:24825450

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

gelsolin

increases expression

4-hydroxy-2-nonenal results in increased expression of GSN mRNA

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione-disulfide reductase

increases expression

4-hydroxy-2-nonenal results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

increases expression

4-hydroxy-2-nonenal results in increased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 1

decreases response to substance
increases expression
affects metabolic processing
multiple interactions

GSTA1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNA
GSTA1 protein affects the metabolism of 4-hydroxy-2-nonenal analog
[GSTA1 protein binds to GSTA3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog

PMID:9799558 PMID:11256969 PMID:15829614

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 3

multiple interactions

[GSTA1 protein binds to GSTA3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase alpha 4

multiple interactions
affects metabolic processing
increases expression

GSTA4 protein binds to and affects the metabolism of 4-hydroxy-2-nonenal
GSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal; GSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal analog
4-hydroxy-2-nonenal results in increased expression of GSTA4 mRNA; 4-hydroxy-2-nonenal results in increased expression of GSTA4 protein

PMID:2619714 PMID:7878679 PMID:8142470 PMID:8203886 PMID:9461507 More...

NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase alpha 5

increases expression

4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNA

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase mu 1

multiple interactions
affects metabolic processing

[GSTM1 protein co-treated with 4-hydroxy-2-nonenal] results in decreased abundance of Glutathione; [GSTM1 protein co-treated with ABCC1 protein] results in increased susceptibility to 4-hydroxy-2-nonenal
GSTM1 protein affects the metabolism of 4-hydroxy-2-nonenal analog
[GSTM1 protein binds to GSTM2 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog

PMID:11256969 PMID:21925487

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

decreases response to substance
multiple interactions
affects metabolic processing

GSTM2 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
[GSTM1 protein binds to GSTM2 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog
GSTM2 protein affects the metabolism of 4-hydroxy-2-nonenal analog

PMID:11256969 PMID:15829614

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

multiple interactions
decreases response to substance
increases expression
affects binding
decreases expression

4-hydroxy-2-nonenal binds to and results in decreased activity of GSTP1 protein
GSTP1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of GSTP1 protein
4-hydroxy-2-nonenal analog binds to GSTP1
4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein
Glutathione inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein]
4-hydroxy-2-nonenal results in increased expression of GSTP1 mRNA

PMID:9463521 PMID:11600134 PMID:15829614 PMID:18232660 PMID:19191707 More...

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

general transcription factor IIB

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GTF2B mRNA

NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651

G

H2A.X variant histone

multiple interactions
increases expression
increases phosphorylation

POLH protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; POLK protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; POLL protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; REV1 protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; REV3L protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
4-hydroxy-2-nonenal results in increased expression of H2AX protein
[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in increased expression of H2AX protein

PMID:22331492 PMID:34503147

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

decreases activity

4-hydroxy-2-nonenal results in decreased activity of H6PD protein

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

histone H3 associated protein kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HASPIN mRNA

NCBI chr10:57,747,731...57,750,518
Ensembl chr10:57,747,573...57,750,512

G

heparin-binding EGF-like growth factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HBEGF mRNA

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

HMG-box transcription factor 1

increases expression

4-hydroxy-2-nonenal results in increased expression of HBP1 mRNA

NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787

G

HCK proto-oncogene, Src family tyrosine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HCK mRNA

NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693

G

histidine decarboxylase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HDC mRNA

NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341

G

helicase, lymphoid specific

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HELLS mRNA

NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844

G

HECT and RLD domain containing E3 ubiquitin protein ligase 3

increases expression

4-hydroxy-2-nonenal results in increased expression of HERC3 mRNA

NCBI chr 4:87,952,202...88,042,492
Ensembl chr 4:87,952,274...88,042,488

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HERC5 mRNA

NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744

G

hepatocyte growth factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

histidine triad nucleotide binding protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HINT1 mRNA

NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568

G

HIVEP zinc finger 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HIVEP2 mRNA

PMID:12419474 PMID:19191707

NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993

G

HIVEP zinc finger 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HIVEP3 mRNA

NCBI chr 5:133,325,327...133,727,797
Ensembl chr 5:133,658,052...133,727,795

G

H2.0-like homeobox

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HLX mRNA

NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750

G

high mobility group AT-hook 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HMGA1 mRNA

NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752

G

high mobility group AT-hook 2

increases expression

4-hydroxy-2-nonenal results in increased expression of HMGA2 mRNA

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

heme oxygenase 1

increases expression
multiple interactions

4-hydroxy-2-nonenal analog results in increased expression of HMOX1; 4-hydroxy-2-nonenal results in increased expression of HMOX1; 4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA; 4-hydroxy-2-nonenal results in increased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; methyl-beta-cyclodextrin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]
4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]

PMID:18232660 PMID:19191707 PMID:20638469 PMID:23845594 PMID:24291486 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hepatocyte nuclear factor 4, alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HNF4A mRNA

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

hypoxanthine phosphoribosyltransferase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

hydroxysteroid (17-beta) dehydrogenase 11

increases expression

4-hydroxy-2-nonenal results in increased expression of HSD17B11 mRNA

NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161

G

heat shock protein 90 alpha family class A member 1

affects binding

4-hydroxy-2-nonenal binds to HSP90AA1 protein
4-hydroxy-2-nonenal analog binds to HSP90AA1

PMID:18232660 PMID:21749116

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

affects binding

4-hydroxy-2-nonenal binds to HSP90AB1 protein

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1A

affects binding

4-hydroxy-2-nonenal analog binds to HSPA1A

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

increases expression

4-hydroxy-2-nonenal results in increased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 1 like

affects binding

4-hydroxy-2-nonenal analog binds to HSPA1L

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

heat shock protein family A (Hsp70) member 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HSPA2 mRNA

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 4 like

increases expression

4-hydroxy-2-nonenal results in increased expression of HSPA4L mRNA

NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084

G

heat shock protein family A (Hsp70) member 5

affects binding
multiple interactions
increases expression

4-hydroxy-2-nonenal analog binds to HSPA5
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA]
4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA; 4-hydroxy-2-nonenal results in increased expression of HSPA5 protein

PMID:18232660 PMID:24291486

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 9

affects binding

4-hydroxy-2-nonenal analog binds to HSPA9

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family D (Hsp60) member 1

affects binding

4-hydroxy-2-nonenal analog binds to HSPD1

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family H (Hsp110) member 1

increases expression

4-hydroxy-2-nonenal results in increased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

HIV-1 Tat interactive protein 2

increases expression

4-hydroxy-2-nonenal results in increased expression of HTATIP2 mRNA

NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629

G

HUS1 checkpoint clamp component

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HUS1 mRNA

NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442

G

intercellular adhesion molecule 1

increases expression

4-hydroxy-2-nonenal results in increased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ID1 mRNA

PMID:12419474 PMID:19191707

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

isocitrate dehydrogenase (NADP(+)) 1

increases expression

4-hydroxy-2-nonenal results in increased expression of IDH1 mRNA

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

immediate early response 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IER3 mRNA

PMID:12419474 PMID:19191707

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

interferon-induced protein 44-like

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IFI44L mRNA

NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359

G

interferon induced with helicase C domain 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IFIH1 mRNA

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456

G

interferon-induced protein with tetratricopeptide repeats 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IFIT2 mRNA

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon induced transmembrane protein 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IFITM2 mRNA

NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741

G

interferon beta 1

multiple interactions

4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein]

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

multiple interactions

[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein; [Trichloroethylene co-treated with 4-hydroxy-2-nonenal analog] results in increased expression of IFNG protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein]

PMID:18267128 PMID:33007382

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

increases expression

4-hydroxy-2-nonenal results in increased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IGF1R mRNA

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

increases expression

4-hydroxy-2-nonenal results in increased expression of IKBKE mRNA

NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143

G

IKAROS family zinc finger 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IKZF1 mRNA

NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416

G

interleukin 10

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL10 mRNA

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 10 receptor subunit alpha

increases expression

4-hydroxy-2-nonenal results in increased expression of IL10RA mRNA

NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061

G

interleukin 12 receptor subunit beta 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL12RB1 mRNA

NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769

G

interleukin 13 receptor subunit alpha 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL13RA1 mRNA

NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681

G

interleukin 17A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL17A mRNA

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL18 mRNA

PMID:12419474 PMID:19191707

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 18 receptor accessory protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL18RAP mRNA

NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959

G

interleukin 1 alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL1RL1 mRNA

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 1 receptor antagonist

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL1RN mRNA

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

multiple interactions

[Trichloroethylene co-treated with 4-hydroxy-2-nonenal analog] results in increased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 27

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL27 mRNA

NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582

G

interleukin 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL3 mRNA

NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066

G

interleukin 36, alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL36A mRNA

NCBI chr 3:6,996,851...7,001,400
Ensembl chr 3:6,996,851...7,001,400

G

interleukin 4 receptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL4RA mRNA

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

G

interleukin 6

decreases expression
multiple interactions

4-hydroxy-2-nonenal results in decreased expression of IL6 mRNA
[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein]

PMID:19191707 PMID:33007382

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL6R mRNA

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

interleukin 6 cytokine family signal transducer

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL6ST mRNA

PMID:12419474 PMID:19191707

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

interleukin 7 receptor

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of IL7R mRNA
4-hydroxy-2-nonenal results in increased expression of IL7R mRNA

PMID:12419474 PMID:19191707

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

G

interleukin 9

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL9 mRNA

NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895

G

impact RWD domain protein

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of IMPACT mRNA
4-hydroxy-2-nonenal results in increased expression of IMPACT mRNA

NCBI chr18:4,108,872...4,147,571
Ensembl chr18:4,108,853...4,147,569

G

inositol polyphosphate phosphatase-like 1

increases expression

4-hydroxy-2-nonenal results in increased expression of INPPL1 mRNA

NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500

G

insulin induced gene 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of INSIG2 mRNA

NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923

G

interleukin-1 receptor-associated kinase 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IRAK3 mRNA

NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121

G

interferon regulatory factor 3

multiple interactions

4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]

NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935

G

interferon regulatory factor 7

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

interferon regulatory factor 8

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IRF8 mRNA

NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829

G

immunity-related GTPase M

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IRGM mRNA

NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578

G

ISG15 ubiquitin-like modifier

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

interferon stimulated exonuclease gene 20

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ISG20 mRNA

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

G

integrin subunit alpha 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITGA5 mRNA

NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837

G

integrin subunit alpha 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITGA6 mRNA

NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428

G

integrin subunit alpha 7

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITGA7 mRNA

NCBI chr 7:1,360,125...1,388,886
Ensembl chr 7:1,359,940...1,388,450

G

integrin subunit alpha L

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITGAL mRNA

NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732

G

integrin subunit alpha M

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITGAM mRNA

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit beta 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITGB6 mRNA

NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671

G

intersectin 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITSN1 mRNA

NCBI chr11:30,978,590...31,160,645
Ensembl chr11:30,978,590...31,160,645

G

Janus kinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun dimerization protein 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of JDP2 mRNA

NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions
increases phosphorylation
affects response to substance

4-hydroxy-2-nonenal results in decreased expression of JUN mRNA
4-hydroxy-2-nonenal promotes the reaction [JUN protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]; 4-hydroxy-2-nonenal results in increased expression of and results in increased localization of JUN protein; 4-hydroxy-2-nonenal results in increased expression of and results in increased phosphorylation of JUN protein; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; Quercetin inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]
JUN protein affects the susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]; 4-hydroxy-2-nonenal results in increased expression of and results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of and results in increased phosphorylation of JUN protein]

PMID:9890986 PMID:11488593 PMID:12419474 PMID:16195535 PMID:16322078 More...

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

4-hydroxy-2-nonenal promotes the reaction [JUNB protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]

PMID:9890986 PMID:16195535

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

4-hydroxy-2-nonenal results in decreased expression of JUND mRNA
4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]

PMID:9890986 PMID:12419474

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

lysine acetyltransferase 8

increases expression

4-hydroxy-2-nonenal results in increased expression of KAT8 mRNA

NCBI chr 1:182,524,355...182,536,638
Ensembl chr 1:182,515,327...182,536,633

G

lysine demethylase 6B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of KDM6B mRNA

NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794

G

kinesin family member 11

decreases expression

4-hydroxy-2-nonenal results in decreased expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 20B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of KIF20B mRNA

NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787

G

KIT ligand

increases expression

4-hydroxy-2-nonenal results in increased expression of KITL mRNA

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

KLF transcription factor 7

decreases expression

4-hydroxy-2-nonenal results in decreased expression of KLF7 mRNA

NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261

G

kelch-like family member 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of KLHL6 mRNA

NCBI chr11:80,970,917...81,010,593
Ensembl chr11:80,970,917...81,009,677

G

karyopherin subunit alpha 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of KPNA2 mRNA

NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150

G

lysosomal-associated membrane protein 1

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of LAMP1 mRNA; 4-hydroxy-2-nonenal results in increased expression of LAMP1 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of LAMP1 protein]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of LAMP1 protein]

NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883

G

linker for activation of T cells

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LAT mRNA

NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578

G

lecithin cholesterol acyltransferase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LCAT mRNA

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

LCK proto-oncogene, Src family tyrosine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LCK mRNA

NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794

G

LIF, interleukin 6 family cytokine

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LIF mRNA

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

lipase A, lysosomal acid type

increases expression

4-hydroxy-2-nonenal results in increased expression of LIPA mRNA

NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633

G

lipase G, endothelial type

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LIPG mRNA

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

G

lysophosphatidic acid receptor 1

increases expression

4-hydroxy-2-nonenal results in increased expression of LPAR1 mRNA

NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895

G

lipin 1

increases expression

4-hydroxy-2-nonenal results in increased expression of LPIN1 mRNA

NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097

G

leucine rich repeat containing 59

affects binding

LRRC59 protein binds to 4-hydroxy-2-nonenal

NCBI chr10:79,572,295...79,586,953
Ensembl chr10:79,572,317...79,602,533

G

LRR binding FLII interacting protein 2

increases expression

4-hydroxy-2-nonenal results in increased expression of LRRFIP2 mRNA

NCBI chr 8:111,091,453...111,193,947
Ensembl chr 8:111,091,503...111,193,255

G

lymphotoxin beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LTB mRNA

NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381

G

lymphocyte antigen 6 family member E

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LY6E mRNA

NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689

G

lymphocyte antigen 96

increases expression

4-hydroxy-2-nonenal results in increased expression of LY96 mRNA

NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386

G

LYN proto-oncogene, Src family tyrosine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LYN mRNA

PMID:12419474 PMID:19191707

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

MAF1 homolog, negative regulator of RNA polymerase III

increases expression

4-hydroxy-2-nonenal results in increased expression of MAF1 mRNA

NCBI chr 7:108,075,173...108,078,252
Ensembl chr 7:108,075,189...108,078,249

G

MAF bZIP transcription factor B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MAFB mRNA

NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031

G

MAF bZIP transcription factor G

increases expression

4-hydroxy-2-nonenal results in increased expression of MAFG mRNA

NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026

G

microtubule-associated protein 1 light chain 3 beta

increases expression

4-hydroxy-2-nonenal results in increased expression of MAP1LC3B mRNA

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MAP2K5 mRNA

NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983

G

mitogen-activated protein kinase kinase kinase 20

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MAP3K20 mRNA

NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626

G

mitogen activated protein kinase 1

decreases activity
multiple interactions
increases phosphorylation

4-hydroxy-2-nonenal results in decreased activity of MAPK1 protein
4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; 4-hydroxy-2-nonenal results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]; 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]
4-hydroxy-2-nonenal results in increased phosphorylation of MAPK1 protein
4-hydroxy-2-nonenal results in increased activity of and results in increased phosphorylation of MAPK1 protein

PMID:16322078 PMID:17263905 PMID:23845594 PMID:24291486 PMID:24423726

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions
increases expression

4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein; Acetylcysteine inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; Hydrogen Peroxide promotes the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein]
4-hydroxy-2-nonenal results in increased expression of MAPK14 mRNA
4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein]

PMID:12684028 PMID:16322078 PMID:19191707

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

decreases activity
multiple interactions
increases phosphorylation

4-hydroxy-2-nonenal results in decreased activity of MAPK3 protein
4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; 4-hydroxy-2-nonenal results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]; 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK3 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]
4-hydroxy-2-nonenal results in increased phosphorylation of MAPK3 protein
4-hydroxy-2-nonenal results in increased activity of and results in increased phosphorylation of MAPK3 protein

PMID:16322078 PMID:17263905 PMID:23845594 PMID:24291486 PMID:24423726

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases activity
increases phosphorylation
affects response to substance
multiple interactions

4-hydroxy-2-nonenal results in increased activity of MAPK8 protein
4-hydroxy-2-nonenal results in increased phosphorylation of MAPK8 protein
MAPK8 protein affects the susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein; GSTA4 protein inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of MAPK8 protein]; Resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein]
4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein; Hydrogen Peroxide promotes the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein]

PMID:11488593 PMID:12684028 PMID:15064094 PMID:16322078 PMID:17263905 More...

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

increases phosphorylation

4-hydroxy-2-nonenal results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MARCKS-like 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MARCKSL1 mRNA

NCBI chr 5:141,851,491...141,853,814
Ensembl chr 5:141,850,110...141,853,817

G

microtubule affinity regulating kinase 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MARK3 mRNA

NCBI chr 6:130,626,612...130,716,245
Ensembl chr 6:130,627,482...130,716,647

G

minichromosome maintenance complex component 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 6

increases expression

4-hydroxy-2-nonenal results in increased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

methionyl aminopeptidase type 1D (mitochondrial)

increases expression

4-hydroxy-2-nonenal results in increased expression of METAP1D mRNA

NCBI chr 3:56,279,471...56,354,518
Ensembl chr 3:56,279,493...56,351,981

G

methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit

multiple interactions

METTL14 protein promotes the reaction [Doxorubicin results in increased abundance of 4-hydroxy-2-nonenal]

NCBI chr 2:211,530,598...211,546,845
Ensembl chr 2:211,530,602...211,546,821

G

melanocyte inducing transcription factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MITF mRNA

NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145

G

marker of proliferation Ki-67

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MAPK interacting serine/threonine kinase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MKNK1 mRNA

NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639

G

mutL homolog 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MLH1 mRNA

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

matrix metallopeptidase 1

increases activity
increases expression

4-hydroxy-2-nonenal results in increased activity of MMP1 protein
4-hydroxy-2-nonenal results in increased expression of MMP1 mRNA

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 2

increases activity
increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased activity of MMP2 protein
4-hydroxy-2-nonenal results in increased expression of MMP2 mRNA
1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2]; 4-hydroxy-2-nonenal results in increased expression of and results in increased secretion of and results in increased activity of MMP2 protein; AKT1 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2 protein]

PMID:14672615 PMID:18805481

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression
increases activity
multiple interactions
increases expression

4-hydroxy-2-nonenal results in decreased expression of MMP9 mRNA
4-hydroxy-2-nonenal results in increased activity of MMP9 protein
ALOX5 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]; alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]; MK-886 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]; U 75302 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]
4-hydroxy-2-nonenal results in increased expression of MMP9 mRNA; 4-hydroxy-2-nonenal results in increased expression of MMP9 protein

PMID:19191707 PMID:19837106

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloid cell nuclear differentiation antigen

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IFI16 mRNA; 4-hydroxy-2-nonenal results in decreased expression of IFI204 mRNA
4-hydroxy-2-nonenal results in decreased expression of MNDA mRNA

PMID:12419474 PMID:19191707

NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201

G

molybdenum cofactor sulfurase

increases expression

4-hydroxy-2-nonenal results in increased expression of MOCOS mRNA

NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187

G

Mov10 RNA helicase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MOV10 mRNA

NCBI chr 2:192,292,041...192,315,142
Ensembl chr 2:192,293,470...192,315,083

G

membrane spanning 4-domains A6A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MS4A6C mRNA

NCBI chr 1:208,401,465...208,414,831
Ensembl chr 1:208,401,466...208,414,758

G

mutS homolog 5

increases expression

4-hydroxy-2-nonenal results in increased expression of MSH5 mRNA

NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336

G

metallothionein 1

increases expression

4-hydroxy-2-nonenal results in increased expression of MT1 mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

metallothionein 2A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MT2 mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

methenyltetrahydrofolate synthetase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MTHFS mRNA

NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089

G

myotubularin related protein 10

increases expression

4-hydroxy-2-nonenal results in increased expression of MTMR10 mRNA

NCBI chr 1:117,859,355...117,910,839
Ensembl chr 1:117,859,267...117,910,849

G

mechanistic target of rapamycin kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MTOR mRNA

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MTSS I-BAR domain containing 1

increases expression

4-hydroxy-2-nonenal results in increased expression of MTSS1 mRNA

NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968

G

mutY DNA glycosylase

increases expression

4-hydroxy-2-nonenal results in increased expression of MUTYH mRNA

NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146

G

MX dynamin like GTPase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MX1 mRNA

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

MX dynamin like GTPase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MX2 mRNA

NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342

G

max dimerization protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MXD1 mRNA

NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751

G

MYB proto-oncogene like 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin light chain kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MYLK mRNA

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

Ngfi-A binding protein 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NAB2 mRNA

NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989

G

NSF attachment protein beta

increases expression

4-hydroxy-2-nonenal results in increased expression of NAPB mRNA

NCBI chr 3:136,132,248...136,179,280
Ensembl chr 3:136,133,428...136,179,345

G

nibrin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NBN mRNA

PMID:12419474 PMID:19191707

NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150

G

NCK adaptor protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NCK1 mRNA

NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300

G

NDC80 kinetochore complex component

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NDC80 mRNA

NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924

G

nectin cell adhesion molecule 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NECTIN1 mRNA

NCBI chr 8:44,101,776...44,164,863
Ensembl chr 8:44,101,776...44,189,787

G

nei-like DNA glycosylase 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NEIL3 mRNA

NCBI chr16:38,359,305...38,418,528
Ensembl chr16:38,359,371...38,418,527

G

NIMA-related kinase 2

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of NEK2 mRNA
4-hydroxy-2-nonenal results in increased expression of NEK2 mRNA

NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051

G

NIMA-related kinase 3

increases expression

4-hydroxy-2-nonenal results in increased expression of NEK3 mRNA

NCBI chr16:69,867,020...69,892,477
Ensembl chr16:69,867,047...69,892,508

G

NIMA-related kinase 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NEK6 mRNA

NCBI chr 3:22,284,269...22,356,302
Ensembl chr 3:22,284,279...22,395,990

G

neogenin 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NEO1 mRNA

NCBI chr 8:59,273,860...59,426,486
Ensembl chr 8:59,275,569...59,430,348

G

neuraminidase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of NEU1 mRNA

NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745

G

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NF2 mRNA

NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667

G

NFAT activating protein with ITAM motif 1

increases expression

4-hydroxy-2-nonenal results in increased expression of NFAM1 mRNA

NCBI chr 7:114,139,318...114,175,395
Ensembl chr 7:114,139,345...114,175,442

G

nuclear factor of activated T-cells 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NFATC1 mRNA

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

NFE2 like bZIP transcription factor 1

decreases expression
multiple interactions
increases expression

4-hydroxy-2-nonenal results in decreased expression of NFE2L1 mRNA
4-hydroxy-2-nonenal promotes the reaction [NFE2L1 protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal results in increased expression of and results in increased localization of NFE2L1 protein
4-hydroxy-2-nonenal results in increased expression of NFE2L1 protein

PMID:12419474 PMID:16195535

NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318

G

NFE2 like bZIP transcription factor 2

decreases activity
multiple interactions
affects response to substance
affects localization
increases expression

4-hydroxy-2-nonenal results in decreased activity of NFE2L2 protein
AKR7A2 protein affects the reaction [NFE2L2 protein affects the susceptibility to 4-hydroxy-2-nonenal]
4-hydroxy-2-nonenal affects the localization of NFE2L2 protein
4-hydroxy-2-nonenal affects the localization of and results in increased activity of NFE2L2 protein; [GSTA4 protein mutant form results in decreased glutathionylation of 4-hydroxy-2-nonenal] which results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased activity of NFE2L2 protein]
4-hydroxy-2-nonenal results in increased expression of NFE2L2 protein
4-hydroxy-2-nonenal promotes the reaction [NFE2L2 protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal results in increased expression of and results in increased localization of NFE2L2 protein; NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]

PMID:16195535 PMID:16322078 PMID:19880816 PMID:24291486 PMID:24423726 More...

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

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nuclear factor I/C

increases expression

4-hydroxy-2-nonenal results in increased expression of NFIC mRNA

NCBI chr 7:8,278,210...8,309,936
Ensembl chr 7:8,253,361...8,309,936

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nuclear factor I X

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NFIX mRNA

NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265

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nuclear factor kappa B subunit 1

decreases expression
multiple interactions

4-hydroxy-2-nonenal results in decreased expression of NFKB1 mRNA
4-hydroxy-2-nonenal results in decreased activity of [NFKB1 protein binds to NFKB1 protein]; 4-hydroxy-2-nonenal results in decreased activity of [RELA protein binds to NFKB1 protein]

PMID:11146106 PMID:12419474 PMID:19191707

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

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NFKB inhibitor alpha

multiple interactions
increases expression

4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
4-hydroxy-2-nonenal results in increased expression of NFKBIA mRNA

PMID:19191707 PMID:19627980

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

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NFKB inhibitor epsilon

increases expression

4-hydroxy-2-nonenal results in increased expression of NFKBIE mRNA

NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437

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NFKB inhibitor zeta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NFKBIZ mRNA

NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723

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nuclear factor related to kappa B binding protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NFRKB mRNA

NCBI chr 8:29,831,802...29,863,360
Ensembl chr 8:29,831,812...29,863,359

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nuclear transcription factor, X-box binding 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NFX1 mRNA

NCBI chr 5:56,104,945...56,162,912
Ensembl chr 5:56,105,234...56,162,912

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NFKB inhibitor interacting Ras-like 1

increases expression

4-hydroxy-2-nonenal results in increased expression of NKIRAS1 mRNA

NCBI chr15:7,493,531...7,503,758
Ensembl chr15:7,493,531...7,503,854

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NLR family, CARD domain containing 4

increases expression

4-hydroxy-2-nonenal results in increased expression of NLRC4 mRNA

NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248

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NLR family, pyrin domain containing 10

increases expression

4-hydroxy-2-nonenal results in increased expression of NLRP10 mRNA

NCBI chr 1:162,922,806...162,930,363
Ensembl chr 1:162,922,806...162,930,363

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NLR family, pyrin domain containing 3

increases expression

4-hydroxy-2-nonenal results in increased expression of NLRP3 mRNA

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

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neuromedin B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NMB mRNA

NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190

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NME/NM23 nucleoside diphosphate kinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NME2 mRNA

NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538

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nitric oxide synthase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NOS2 protein

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

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notch receptor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NOTCH1 mRNA

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

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NAD(P)H quinone dehydrogenase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of NQO1 mRNA
4-hydroxy-2-nonenal results in increased expression of NQO1 mRNA; 4-hydroxy-2-nonenal results in increased expression of NQO1 protein

PMID:24423726 PMID:29108775 PMID:30849339

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

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nuclear receptor subfamily 1, group D, member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

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nuclear receptor subfamily 1, group D, member 2

increases expression

4-hydroxy-2-nonenal results in increased expression of NR1D2 mRNA

NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553

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nuclear receptor subfamily 1, group I, member 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NR1I3 mRNA

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

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nuclear receptor subfamily 2, group F, member 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NR2F6 mRNA

NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459

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nuclear receptor subfamily 3, group C, member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

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nuclear receptor subfamily 4, group A, member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

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neuropilin 1

increases expression

4-hydroxy-2-nonenal results in increased expression of NRP1 mRNA

NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633

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NSL1 component of MIS12 kinetochore complex

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NSL1 mRNA

NCBI chr13:102,649,050...102,674,059
Ensembl chr13:102,649,058...102,674,054

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NUF2 component of NDC80 kinetochore complex

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NUF2 mRNA

NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766

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nuclear FMR1 interacting protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NUFIP1 mRNA

NCBI chr15:51,429,518...51,460,308
Ensembl chr15:51,429,549...51,460,310

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nucleoporin 210

increases expression

4-hydroxy-2-nonenal results in increased expression of NUP210 mRNA

NCBI chr 4:123,511,558...123,609,874
Ensembl chr 4:123,511,559...123,609,874

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nucleoporin 85

increases expression

4-hydroxy-2-nonenal results in increased expression of NUP85 mRNA

NCBI chr10:100,806,482...100,825,029
Ensembl chr10:100,806,437...100,825,043

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nucleolar and spindle associated protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NUSAP1 mRNA

NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624

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2'-5'-oligoadenylate synthetase 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of OAS3 mRNA

NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781

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olfactory receptor 1271

increases expression

4-hydroxy-2-nonenal results in increased expression of OR8D1 mRNA; 4-hydroxy-2-nonenal results in increased expression of OR8D1B mRNA

NCBI chr 8:39,127,409...39,131,889
Ensembl chr 8:39,127,352...39,131,900

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oncostatin M

decreases expression

4-hydroxy-2-nonenal results in decreased expression of OSM mRNA

NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313

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OTU deubiquitinase, ubiquitin aldehyde binding 1

multiple interactions

[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenal

NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483

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purinergic receptor P2X 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of P2RX5 mRNA

NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423

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purinergic receptor P2Y2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of P2RY2 mRNA

NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632

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prolyl 4-hydroxylase subunit beta

affects metabolic processing

4-hydroxy-2-nonenal affects the metabolism of P4HB protein

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

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proliferation-associated 2G4

increases expression

4-hydroxy-2-nonenal results in increased expression of PA2G4 mRNA

NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331

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poly(A) binding protein interacting protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PAIP1 mRNA

NCBI chr 2:51,523,190...51,550,241
Ensembl chr 2:51,522,921...51,550,241

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poly (ADP-ribose) polymerase 1

increases degradation

4-hydroxy-2-nonenal results in increased degradation of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

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poly (ADP-ribose) polymerase family, member 12

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PARP12 mRNA

NCBI chr 4:67,826,548...67,885,356
Ensembl chr 4:67,839,237...67,883,685

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PDZ binding kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PBK mRNA

NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014

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polycomb group ring finger 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PCGF5 mRNA

NCBI chr 1:234,063,854...234,180,022
Ensembl chr 1:234,063,892...234,175,315

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proliferating cell nuclear antigen

increases expression

4-hydroxy-2-nonenal results in increased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

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proprotein convertase subtilisin/kexin type 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PCSK2 mRNA

NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127

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prenylcysteine oxidase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of PCYOX1 mRNA

NCBI chr 4:118,832,114...118,842,951
Ensembl chr 4:118,830,638...118,842,951

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programmed cell death 4

increases expression

4-hydroxy-2-nonenal results in increased expression of PDCD4 mRNA

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

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platelet derived growth factor subunit B

increases expression

4-hydroxy-2-nonenal results in increased expression of PDGFB mRNA

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

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protein disulfide isomerase family A, member 3

affects binding

4-hydroxy-2-nonenal analog binds to PDIA3

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

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decaprenyl diphosphate synthase subunit 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PDSS1 mRNA

NCBI chr17:85,059,953...85,098,739
Ensembl chr17:85,060,106...85,098,730

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prodynorphin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PDYN mRNA

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

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proenkephalin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PENK mRNA

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

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period circadian regulator 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PER1 mRNA

NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431

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peroxisomal biogenesis factor 7

increases expression

4-hydroxy-2-nonenal results in increased expression of PEX7 mRNA

NCBI chr 1:14,582,698...14,646,686
Ensembl chr 1:14,582,699...14,646,748

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phosphogluconate dehydrogenase

increases expression

4-hydroxy-2-nonenal results in increased expression of PGD mRNA

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

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peptidoglycan recognition protein 3

increases expression

4-hydroxy-2-nonenal results in increased expression of PGLYRP3 mRNA

NCBI chr 2:177,479,693...177,490,769
Ensembl chr 2:177,477,407...177,490,736
Ensembl chr 2:177,477,407...177,490,736

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phosphoglucomutase 2-like 1

increases expression

4-hydroxy-2-nonenal results in increased expression of PGM2L1 mRNA

NCBI chr 1:154,571,410...154,620,901
Ensembl chr 1:154,571,766...154,620,902

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phosphatidylglycerophosphate synthase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PGS1 mRNA

NCBI chr10:103,214,635...103,250,254
Ensembl chr10:103,214,646...103,250,254

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prohibitin 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PHB1 mRNA

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

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PHD finger protein 11

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PHF11 mRNA

NCBI chr15:33,390,290...33,414,647
Ensembl chr15:33,390,292...33,413,009

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PHD finger protein 21A

increases expression

4-hydroxy-2-nonenal results in increased expression of PHF21A mRNA

NCBI chr 3:78,158,760...78,331,903
Ensembl chr 3:78,194,549...78,331,865

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phosphoglycerate dehydrogenase

affects binding

PHGDH protein binds to 4-hydroxy-2-nonenal

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

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pleckstrin homology-like domain, family A, member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PHLDA1 mRNA

NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861

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phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

increases expression

4-hydroxy-2-nonenal results in increased expression of PIK3CB mRNA

NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663

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phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PIK3CD mRNA

NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930

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phosphoinositide-3-kinase regulatory subunit 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PIK3R2 mRNA

NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065

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paired immunoglobin-like type 2 receptor alpha

increases expression

4-hydroxy-2-nonenal results in increased expression of PILRA mRNA

NCBI chr12:17,787,169...17,798,149
Ensembl chr12:17,787,127...17,798,094

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peptidylprolyl cis/trans isomerase, NIMA-interacting 1

affects binding
increases response to substance

4-hydroxy-2-nonenal binds to PIN1 protein
PIN1 protein results in increased susceptibility to 4-hydroxy-2-nonenal

NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785

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pyruvate kinase M1/2

affects binding
multiple interactions

4-hydroxy-2-nonenal analog binds to PKM protein
4-hydroxy-2-nonenal binds to and results in decreased activity of PKM protein; 4-hydroxy-2-nonenal promotes the reaction [PKM protein binds to PKM protein]

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

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phospholipase A2 group VII

increases expression

4-hydroxy-2-nonenal results in increased expression of PLA2G7 mRNA

NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476

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PLAG1 like zinc finger 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PLAGL2 mRNA

NCBI chr 3:141,695,322...141,708,516
Ensembl chr 3:141,695,322...141,708,503

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phospholipase D2

increases expression

4-hydroxy-2-nonenal results in increased expression of PLD2 mRNA

NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808

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pleckstrin homology and RUN domain containing M1

increases expression

4-hydroxy-2-nonenal results in increased expression of PLEKHM1 mRNA

NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412

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pleckstrin homology domain containing O1

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of PLEKHO1 mRNA
4-hydroxy-2-nonenal results in increased expression of PLEKHO1 mRNA

NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785

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polo-like kinase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

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polo-like kinase 2

increases expression

4-hydroxy-2-nonenal results in increased expression of PLK2 mRNA

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

G

DNA polymerase beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of POLB mRNA

NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812

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DNA polymerase delta 1, catalytic subunit

decreases expression

4-hydroxy-2-nonenal results in decreased expression of POLD1 mRNA

NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465

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DNA polymerase epsilon, catalytic subunit

increases expression

4-hydroxy-2-nonenal results in increased expression of POLE mRNA

NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939

G

DNA polymerase eta

multiple interactions
affects response to substance

POLH protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
POLH protein affects the susceptibility to 4-hydroxy-2-nonenal

NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723

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DNA polymerase kappa

multiple interactions

POLK protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]

NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313

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DNA polymerase lambda

affects response to substance
multiple interactions

POLL protein affects the susceptibility to 4-hydroxy-2-nonenal
POLL protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]

NCBI chr 1:244,400,202...244,408,762
Ensembl chr 1:244,400,204...244,408,662

G

DNA polymerase theta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of POLQ mRNA

NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878

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paraoxonase 1

multiple interactions
decreases activity

4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
4-hydroxy-2-nonenal results in decreased activity of PON1 protein

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

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POU class 2 homeobox 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of POU2F2 mRNA

NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261

G

peroxisome proliferator-activated receptor gamma

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

peptidylprolyl isomerase D

increases expression

4-hydroxy-2-nonenal results in increased expression of PPID mRNA

NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221

G

peptidylprolyl isomerase like 1

increases expression

4-hydroxy-2-nonenal results in increased expression of PPIL1 mRNA

NCBI chr20:7,302,292...7,322,349
Ensembl chr20:7,302,621...7,322,354

G

protein phosphatase 1 catalytic subunit alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PPP1CA mRNA

NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327

G

protein phosphatase 1, regulatory subunit 15A

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of PPP1R15A mRNA
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of PPP1R15A mRNA]

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 1, regulatory subunit 15B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PPP1R15B mRNA

NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737

G

protein phosphatase 3 catalytic subunit alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PPP3CA mRNA

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

PR/SET domain 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PRDM1 mRNA

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

peroxiredoxin 1

affects binding
increases expression

4-hydroxy-2-nonenal analog binds to PRDX1
4-hydroxy-2-nonenal results in increased expression of PRDX1 mRNA

PMID:18232660 PMID:19191707

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

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protein kinase, DNA-activated, catalytic subunit

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PRKDC mRNA

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

protein C receptor

increases expression

4-hydroxy-2-nonenal results in increased expression of PROCR mRNA

NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903

G

proteasome 20S subunit beta 10

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PSMB10 mRNA

NCBI chr19:33,830,958...33,833,442
Ensembl chr19:33,827,229...33,833,626

G

PSMC3 interacting protein

increases expression

4-hydroxy-2-nonenal results in increased expression of PSMC3IP mRNA

NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423

G

proteasome 26S subunit, non-ATPase 12

increases expression

4-hydroxy-2-nonenal results in increased expression of PSMD12 mRNA

NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287

G

prostaglandin E receptor 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PTGER4 mRNA

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin E synthase

increases expression

4-hydroxy-2-nonenal results in increased expression of PTGES mRNA

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin reductase 1

multiple interactions
decreases response to substance

[PTGR1 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-nonenal
PTGR1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

G

protein tyrosine kinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PTK2 mRNA

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, non-receptor type 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PTPN1 mRNA

NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504

G

protein tyrosine phosphatase, receptor type, A

increases expression

4-hydroxy-2-nonenal results in increased expression of PTPRA mRNA

NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728

G

PX domain containing serine/threonine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PXK mRNA

NCBI chr15:16,759,857...16,828,452
Ensembl chr15:16,759,862...16,828,444

G

RAB11a, member RAS oncogene family

increases expression

4-hydroxy-2-nonenal results in increased expression of RAB11A mRNA

NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525

G

RAB guanine nucleotide exchange factor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RABGEF1 mRNA

NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744

G

RAD23 homolog A, nucleotide excision repair protein

increases expression

4-hydroxy-2-nonenal results in increased expression of RAD23A mRNA

NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695

G

RAD51 recombinase

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of RAD51 mRNA
4-hydroxy-2-nonenal results in increased expression of RAD51 mRNA

NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035

G

RAD54 like

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RAD54L mRNA

NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070

G

retinoic acid early transcript 1E

increases expression

4-hydroxy-2-nonenal results in increased expression of RAET1E mRNA

NCBI chr 1:1,662,665...1,664,609
Ensembl chr 1:1,807,644...1,812,755

G

Raf-1 proto-oncogene, serine/threonine kinase

increases expression

4-hydroxy-2-nonenal results in increased expression of RAF1 mRNA

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

ralA binding protein 1

decreases response to substance

RALBP1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal

NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707

G

ral guanine nucleotide dissociation stimulator

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RALGDS mRNA

NCBI chr 3:11,839,686...11,880,059
Ensembl chr 3:11,839,416...11,880,059

G

Ral GEF with PH domain and SH3 binding motif 1

increases expression

4-hydroxy-2-nonenal results in increased expression of RALGPS1 mRNA

NCBI chr 3:16,433,323...16,670,276
Ensembl chr 3:16,433,742...16,669,972

G

retinoic acid receptor, alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RARA mRNA

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RARB mRNA

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

RasGEF domain family, member 1B

increases expression

4-hydroxy-2-nonenal results in increased expression of RASGEF1B mRNA

NCBI chr14:9,859,512...10,380,044
Ensembl chr14:9,860,247...10,379,741

G

RAS guanyl releasing protein 3

increases expression

4-hydroxy-2-nonenal results in increased expression of RASGRP3 mRNA

NCBI chr 6:19,895,361...19,993,945
Ensembl chr 6:19,895,390...19,958,578

G

Ras association domain family member 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RASSF2 mRNA

NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431

G

Ras association domain family member 8

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RASSF8 mRNA

NCBI chr 4:178,716,110...178,798,042
Ensembl chr 4:178,719,992...178,796,690

G

RB transcriptional corepressor 1

decreases phosphorylation
multiple interactions

4-hydroxy-2-nonenal results in decreased phosphorylation of RB1 protein
[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of RB1 protein modified form

PMID:15607904 PMID:33007382

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RB transcriptional corepressor like 1

increases expression

4-hydroxy-2-nonenal results in increased expression of RBL1 mRNA

NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330

G

RB transcriptional corepressor like 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RBL2 mRNA

NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572

G

REL proto-oncogene, NF-kB subunit

decreases expression

4-hydroxy-2-nonenal results in decreased expression of REL mRNA

NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

4-hydroxy-2-nonenal results in decreased activity of [RELA protein binds to NFKB1 protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

REV1, DNA directed polymerase

multiple interactions
affects response to substance

REV1 protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
REV1 protein affects the susceptibility to 4-hydroxy-2-nonenal

NCBI chr 9:40,278,100...40,351,764
Ensembl chr 9:40,278,101...40,351,576

G

REV3 like, DNA directed polymerase zeta catalytic subunit

multiple interactions
affects response to substance

REV3L protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
REV3L protein affects the susceptibility to 4-hydroxy-2-nonenal

NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099

G

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RFFL mRNA

NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434

G

regulator of G-protein signaling 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RGS1 mRNA

NCBI chr13:56,018,546...56,022,889
Ensembl chr13:56,018,554...56,022,984

G

RNA sensor RIG-1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RIGI mRNA

NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819

G

RIO kinase 3

increases expression

4-hydroxy-2-nonenal results in increased expression of RIOK3 mRNA

NCBI chr18:3,327,776...3,353,350
Ensembl chr18:3,327,776...3,353,343

G

Ras-like without CAAX 1

increases expression

4-hydroxy-2-nonenal results in increased expression of RIT1 mRNA

NCBI chr 2:174,180,742...174,195,455
Ensembl chr 2:174,180,848...174,195,455

G

Rho family GTPase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

ring finger protein 128

increases expression

4-hydroxy-2-nonenal results in increased expression of RNF128 mRNA

NCBI chr X:103,183,643...103,298,431
Ensembl chr X:103,183,831...103,298,423

G

ring finger protein 167

increases expression

4-hydroxy-2-nonenal results in increased expression of RNF167 mRNA

NCBI chr10:55,360,603...55,364,927
Ensembl chr10:55,360,543...55,364,927

G

ring finger protein 19B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RNF19B mRNA

NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380

G

ribonuclease P/MRP subunit p38

increases expression

4-hydroxy-2-nonenal results in increased expression of RPP38 mRNA

NCBI chr17:74,914,066...74,917,742
Ensembl chr17:74,908,932...74,927,431

G

ribosomal protein S6 kinase A2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RPS6KA2 mRNA

NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739

G

ribosomal protein S6 kinase B1

increases phosphorylation

4-hydroxy-2-nonenal results in increased phosphorylation of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

radical S-adenosyl methionine domain containing 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

RT1 class Ia, locus A2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of H2-T23 mRNA

NCBI chr20:4,870,939...4,910,183

G

RT1 class I, locus CE16

decreases expression

4-hydroxy-2-nonenal results in decreased expression of H2-Q1 mRNA

NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563

G

retinoid X receptor alpha

increases expression

4-hydroxy-2-nonenal results in increased expression of RXRA mRNA

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

retinoid X receptor beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RXRB mRNA

NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773

G

sphingosine-1-phosphate receptor 2

increases expression

4-hydroxy-2-nonenal results in increased expression of S1PR2 mRNA

NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574

G

SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

affects binding

SAMHD1 protein binds to 4-hydroxy-2-nonenal

NCBI chr 3:145,761,549...145,794,420
Ensembl chr 3:145,761,558...145,794,386

G

SAM domain, SH3 domain and nuclear localization signals, 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SAMSN1 mRNA

NCBI chr11:14,484,523...14,534,900
Ensembl chr11:14,483,893...14,534,900

G

SAS-6 centriolar assembly protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SASS6 mRNA

NCBI chr 2:204,546,660...204,578,930
Ensembl chr 2:204,546,660...204,578,927

G

SATB homeobox 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SATB1 mRNA

NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251

G

strawberry notch homolog 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SBNO2 mRNA

NCBI chr 7:9,605,572...9,649,529
Ensembl chr 7:9,605,627...9,649,527

G

scavenger receptor class B, member 1

multiple interactions
affects binding

Tobacco Smoke Pollution promotes the reaction [4-hydroxy-2-nonenal binds to SCARB1 protein]

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

selenium binding protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SELENBP1 mRNA

NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594

G

Serpine1 mRNA binding protein 1

affects binding

SERBP1 protein binds to 4-hydroxy-2-nonenal

NCBI chr 4:96,401,587...96,421,816
Ensembl chr 4:96,401,477...96,421,813

G

serpin family B member 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SERPINB5 mRNA

NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756

G

serpin family B member 9

increases expression

4-hydroxy-2-nonenal results in increased expression of SERPINB9 mRNA

NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230

G

serpin family I member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SERPINI1 mRNA

NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135

G

sestrin 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SESN2 mRNA

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

serum/glucocorticoid regulated kinase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SGK1 mRNA

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

shugoshin 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SGO1 mRNA

NCBI chr 9:6,672,109...6,687,908
Ensembl chr 9:6,672,123...6,687,805

G

shugoshin 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SGO2 mRNA

NCBI chr 9:59,548,605...59,573,229
Ensembl chr 9:59,548,683...59,573,229

G

sphingosine-1-phosphate lyase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of SGPL1 mRNA

NCBI chr20:29,047,793...29,094,209
Ensembl chr20:29,047,796...29,094,084

G

SHOC2 leucine-rich repeat scaffold protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SHOC2 mRNA

NCBI chr 1:252,958,939...253,048,820
Ensembl chr 1:252,959,723...253,047,337

G

sirtuin 1

multiple interactions

SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 3

multiple interactions

4-hydroxy-2-nonenal binds to and results in decreased activity of SIRT3 protein

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

G

solute carrier family 25, member 27

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SLC25A27 mRNA

NCBI chr 9:17,306,898...17,333,942
Ensembl chr 9:17,307,023...17,332,731

G

solute carrier family 7 member 11

multiple interactions

[APC protein mutant form results in increased expression of SLC7A11 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenal

PMID:21967605 PMID:35234341

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier family 7 member 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SLC7A2 mRNA

NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784

G

SMAD family member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SMAD1 mRNA

NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651

G

structural maintenance of chromosomes 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SMC4 mRNA

NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571

G

small nuclear RNA activating complex, polypeptide 5

increases expression

4-hydroxy-2-nonenal results in increased expression of SNAPC5 mRNA

NCBI chr 8:64,677,204...64,680,769
Ensembl chr 8:64,677,205...64,681,964

G

suppressor of cytokine signaling 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SOCS3 mRNA

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

superoxide dismutase 2

affects binding
increases abundance
multiple interactions
decreases abundance
increases expression

4-hydroxy-2-nonenal binds to SOD2 protein
SOD2 gene mutant form results in increased abundance of 4-hydroxy-2-nonenal
SOD2 protein inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased abundance of 4-hydroxy-2-nonenal]
SOD2 protein results in decreased abundance of 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of SOD2 mRNA

PMID:11507057 PMID:19191707 PMID:19374891 PMID:23199288

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SP100 nuclear antigen

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SP100 mRNA

NCBI chr 9:86,310,990...86,377,036
Ensembl chr 9:86,311,032...86,377,034

G

SP110 nuclear body protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SP110 mRNA

NCBI chr 9:86,200,503...86,225,355
Ensembl chr 9:86,200,503...86,222,670

G

Sp2 transcription factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SP2 mRNA

NCBI chr10:81,940,580...81,970,040
Ensembl chr10:81,940,587...81,970,548

G

sperm autoantigenic protein 17

increases expression

4-hydroxy-2-nonenal results in increased expression of SPA17 mRNA

NCBI chr 8:37,307,432...37,318,519
Ensembl chr 8:37,307,557...37,318,639

G

sperm associated antigen 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SPAG5 mRNA

NCBI chr10:63,198,717...63,216,746
Ensembl chr10:63,198,768...63,216,745