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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Vinpocetine
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Accession:CHEBI:32297 term browser browse the term
Synonyms:related_synonym: Formula=C22H26N2O2;   InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1;   InChIKey=DDNCQMVWWZOMLN-IRLDBZIGSA-N;   SMILES=CC[C@@]12CCCN3[C@@H]1C4=C(CC3)C5=CC=CC=C5N4C(=C2)C(=O)OCC;   apovincaminic acid ethyl ester;   bravinton;   cavinton;   ceractin;   ethyl apovincaminate;   ethyl apovincaminate tartrate;   vinporal
 alt_id: CHEBI:92929
 xref: CAS:42971-09-5;   Drug_Central:2828;   KEGG:C12807;   KEGG:D01371;   LINCS:LSM-3178
 xref_mesh: MESH:C013983
 xref: PMID:24134630


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Vinpocetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP vinpocetine inhibits the reaction [Rotenone results in increased activity of ACHE protein] CTD PMID:36965781 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP vinpocetine inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] CTD PMID:32840391 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen multiple interactions EXP vinpocetine inhibits the reaction [AGT protein inhibits the reaction [NPPA protein results in increased abundance of Cyclic GMP]] CTD PMID:11696475 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Alb albumin multiple interactions EXP vinpocetine inhibits the reaction [Acrylamide results in decreased expression of ALB protein]; vinpocetine inhibits the reaction [Thioacetamide results in decreased expression of ALB protein] CTD PMID:32840391 PMID:38348719 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP vinpocetine inhibits the reaction [Fluoxetine results in increased expression of BAX mRNA] CTD PMID:34669537 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP vinpocetine inhibits the reaction [Fluoxetine results in decreased expression of BCL2 mRNA] CTD PMID:34669537 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP vinpocetine inhibits the reaction [Acrylamide results in increased expression of CASP3 protein]; vinpocetine inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; vinpocetine inhibits the reaction [Fluoxetine results in increased activity of CASP3 protein] CTD PMID:34669537 PMID:36270296 PMID:38348719 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP vinpocetine inhibits the reaction [Fluoxetine results in decreased activity of CAT protein]; vinpocetine inhibits the reaction [Rotenone results in decreased activity of CAT protein] CTD PMID:34669537 PMID:36965781 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP vinpocetine inhibits the reaction [Doxorubicin results in increased expression of CKM protein] CTD PMID:36270296 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP vinpocetine inhibits the reaction [Fluoxetine results in increased expression of GPT protein] CTD PMID:34669537 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP vinpocetine inhibits the reaction [Acrylamide results in increased expression of HAVCR1 protein] CTD PMID:38348719 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP vinpocetine inhibits the reaction [Doxorubicin results in increased expression of HIF1A protein] CTD PMID:36270296 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP vinpocetine inhibits the reaction [Fluoxetine results in increased expression of HMOX1 protein] CTD PMID:34669537 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO vinpocetine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] CTD PMID:25980587 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il33 interleukin 33 multiple interactions ISO vinpocetine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL33 protein] CTD PMID:25980587 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP vinpocetine inhibits the reaction [Fluoxetine results in increased expression of IL6 protein]; vinpocetine inhibits the reaction [Rotenone results in increased expression of IL6 protein]; vinpocetine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] CTD PMID:32840391 PMID:34669537 PMID:36965781 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO vinpocetine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
vinpocetine results in decreased activity of KCNH2 protein		 CTD PMID:17146843 PMID:19583963 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP vinpocetine inhibits the reaction [Thioacetamide results in increased expression of MKI67 protein] CTD PMID:32840391 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO vinpocetine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MPO protein]
[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]		 CTD PMID:25980587 PMID:26519479 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP vinpocetine inhibits the reaction [Fluoxetine results in increased expression of NFE2L2 protein] CTD PMID:34669537 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP vinpocetine inhibits the reaction [AGT protein inhibits the reaction [NPPA protein results in increased abundance of Cyclic GMP]] CTD PMID:11696475 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Pde7b phosphodiesterase 7B multiple interactions ISO vinpocetine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10814504 NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP vinpocetine inhibits the reaction [Fluoxetine results in decreased expression of PPARG mRNA]; vinpocetine inhibits the reaction [Fluoxetine results in decreased expression of PPARG protein] CTD PMID:34669537 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP vinpocetine inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein] CTD PMID:36270296 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Snca synuclein alpha multiple interactions EXP vinpocetine inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:36965781 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP vinpocetine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein] CTD PMID:32840391 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP vinpocetine inhibits the reaction [Rotenone results in increased expression of TLR4 protein] CTD PMID:36965781 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 vinpocetine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
vinpocetine inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; vinpocetine inhibits the reaction [Fluoxetine results in increased expression of TNF protein]; vinpocetine inhibits the reaction [Rotenone results in increased expression of TNF protein]; vinpocetine inhibits the reaction [Thioacetamide results in increased expression of TNF protein]
[Melatonin co-treated with coenzyme Q10 co-treated with vinpocetine] inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]		 CTD PMID:25980587 PMID:26519479 PMID:32840391 PMID:34669537 PMID:36270296 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP vinpocetine inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:36270296 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP vinpocetine inhibits the reaction [Doxorubicin results in increased expression of VEGFA protein] CTD PMID:36270296 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        biochemical role 19552
          metabolite 19539
            alkaloid 8020
              Vinpocetine 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    main group molecular entity 19803
                      p-block molecular entity 19803
                        carbon group molecular entity 19744
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organonitrogen compound 18832
                                alkaloid 8020
                                  Vinpocetine 30
paths to the root