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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tolvaptan
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Accession:CHEBI:32246 term browser browse the term
Definition:A racemate comprising of equimolar amounts of (R)- and (S)-tolvaptan. It is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency.
Synonyms:exact_synonym: rac-N-{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide
 related_synonym: (+-)-4'-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-o-tolu-m-toluidide;   Formula=C26H25ClN2O3;   Jynarque;   N-(4-{[(5RS)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide;   OPC 41061;   RS-tolvaptan;   jinarc;   samsca;   tolvaptanum
 xref: CAS:150683-30-0;   DrugBank:DB06212;   Drug_Central:4110;   KEGG:D01213
 xref_mesh: MESH:C116664
 xref: PMID:12742979;   PMID:16211205;   PMID:33078835;   PMID:34070416;   PMID:34386666;   PMID:34476570;   PMID:34514204;   PMID:34526469;   PMID:34554640;   PMID:37214762;   PMID:37466863;   PMID:37516894;   PMID:37587049;   PMID:37845144;   PMID:37845430;   PMID:37916285;   PMID:37982946;   PMID:38097698;   PMID:38288467;   PMID:38337413;   PMID:38344178;   PMID:38396765;   PMID:38414126;   PMID:38423003;   PMID:38468548;   PMID:38494546;   PMID:38509003;   PMID:38512373;   PMID:38562967;   PMID:38577748;   PMID:38606040;   PMID:38608748;   PMID:38616432;   PMID:38652561;   PMID:38710808;   PMID:38717378;   Wikipedia:Tolvaptan



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tolvaptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCB11 protein; tolvaptan results in decreased activity of ABCB11 protein CTD PMID:23956101 PMID:26507107 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC2 protein CTD PMID:26507107 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC3 protein CTD PMID:26507107 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC4 protein CTD PMID:26507107 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Alb albumin decreases expression ISO Tolvaptan results in decreased expression of ALB protein CTD PMID:33022361 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Tolvaptan results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Tolvaptan results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Mir122 microRNA 122 increases export ISO tolvaptan results in increased export of MIR122 CTD PMID:29029277 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases activity ISO tolvaptan metabolite results in decreased activity of SLC10A1 protein CTD PMID:26507107 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO tolvaptan results in increased expression of SLPI mRNA; tolvaptan results in increased expression of SLPI protein CTD PMID:28115652 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 multiple interactions ISO Cyclosporine promotes the reaction [SULT1C3 protein results in increased sulfation of and results in increased activity of and results in increased susceptibility to tolvaptan]; SULT1C3 protein results in increased sulfation of and results in increased activity of and results in increased susceptibility to tolvaptan CTD PMID:26660633 NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      chemical substance 14426
        mixture 13744
          racemate 12132
            tolvaptan 11
              DM-4103 0
              DM-4107 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19537
                              organochalcogen compound 19297
                                organooxygen compound 19215
                                  carbon oxoacid 18693
                                    carboxylic acid 18690
                                      carboacyl group 17730
                                        univalent carboacyl group 17730
                                          carbamoyl group 17575
                                            carboxamide 17575
                                              monocarboxylic acid amide 15750
                                                arenecarboxamide 8263
                                                  benzamides 8263
                                                    N-\{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl\}-2-methylbenzamide 11
                                                      (S)-tolvaptan 11
                                                        tolvaptan 11
                                                          DM-4103 0
                                                          DM-4107 0
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