CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: tolvaptan
Accession: CHEBI:32246
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Definition: A racemate comprising of equimolar amounts of (R)- and (S)-tolvaptan. It is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency.
Synonyms: exact_synonym: rac-N-{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide
related_synonym: (+-)-4'-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-o-tolu-m-toluidide; Formula=C26H25ClN2O3; Jynarque; N-(4-{[(5RS)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide; OPC 41061; RS-tolvaptan; jinarc; samsca; tolvaptanum
xref: CAS:150683-30-0; DrugBank:DB06212; Drug_Central:4110; KEGG:D01213
xref_mesh: MESH:C116664
xref: PMID:12742979; PMID:16211205; PMID:33078835; PMID:34070416; PMID:34386666; PMID:34476570; PMID:34514204; PMID:34526469; PMID:34554640; PMID:37214762; PMID:37466863; PMID:37516894; PMID:37587049; PMID:37845144; PMID:37845430; PMID:37916285; PMID:37982946; PMID:38097698; PMID:38288467; PMID:38337413; PMID:38344178; PMID:38396765; PMID:38414126; PMID:38423003; PMID:38468548; PMID:38494546; PMID:38509003; PMID:38512373; PMID:38562967; PMID:38577748; PMID:38606040; PMID:38608748; PMID:38616432; PMID:38652561; PMID:38710808; PMID:38717378; Wikipedia:Tolvaptan
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Abcb11
ATP binding cassette subfamily B member 11
decreases activity
ISO
tolvaptan metabolite results in decreased activity of ABCB11 protein; tolvaptan results in decreased activity of ABCB11 protein
CTD
PMID:23956101 PMID:26507107
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcc2
ATP binding cassette subfamily C member 2
decreases activity
ISO
tolvaptan metabolite results in decreased activity of ABCC2 protein
CTD
PMID:26507107
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
decreases activity
ISO
tolvaptan metabolite results in decreased activity of ABCC3 protein
CTD
PMID:26507107
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcc4
ATP binding cassette subfamily C member 4
decreases activity
ISO
tolvaptan metabolite results in decreased activity of ABCC4 protein
CTD
PMID:26507107
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Alb
albumin
decreases expression
ISO
Tolvaptan results in decreased expression of ALB protein
CTD
PMID:33022361
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
Tolvaptan results in decreased activity of CYP1A1 protein
CTD
PMID:33814510
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Tolvaptan results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Mir122
microRNA 122
increases export
ISO
tolvaptan results in increased export of MIR122
CTD
PMID:29029277
NCBI chr18:58,758,703...58,758,787
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Slc10a1
solute carrier family 10 member 1
decreases activity
ISO
tolvaptan metabolite results in decreased activity of SLC10A1 protein
CTD
PMID:26507107
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
tolvaptan results in increased expression of SLPI mRNA; tolvaptan results in increased expression of SLPI protein
CTD
PMID:28115652
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Sult1c3
sulfotransferase family 1C member 3
multiple interactions
ISO
Cyclosporine promotes the reaction [SULT1C3 protein results in increased sulfation of and results in increased activity of and results in increased susceptibility to tolvaptan]; SULT1C3 protein results in increased sulfation of and results in increased activity of and results in increased susceptibility to tolvaptan
CTD
PMID:26660633
NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030
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