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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tibolone
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Accession:CHEBI:32223 term browser browse the term
Definition:Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.
Synonyms:related_synonym: (17R)-17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one;   (7alpha,17alpha)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one;   (7alpha,17beta)-17-ethynyl-17-hydroxy-7-methylestr-5(10)en-3-one;   17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-one;   17alpha-ethynyl-17beta-hydroxy-7alpha-methylestr-5(10)-en-3-one;   tibolona;   tibolonum
 xref: CAS:5630-53-5
 xref_mesh: MESH:C027385
 xref: Patent:US3340279;   Patent:US3475465;   drugcentral:2655;   kegg.drug:D01639
 chemrof_formula: C21H28O2
 chemrof_inchi: InChI=1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/m1/s1
 chemrof_inchikey: WZDGZWOAQTVYBX-XOINTXKNSA-N
 chemrof_smiles: [H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]1([H])C3=C(CC(=O)CC3)C[C@@H](C)[C@@]21[H]


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tibolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4e C-type lectin domain family 4, member E increases expression ISO tibolone results in increased expression of CLEC4E mRNA CTD PMID:22217510 NCBI chr 4:158,292,624...158,298,607
Ensembl chr 4:158,293,311...158,298,467 		JBrowse link
G Crp C-reactive protein increases expression ISO tibolone results in increased expression of CRP protein CTD PMID:17882670 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO tibolone metabolite results in increased activity of ESR1 protein; tibolone results in increased activity of ESR1 protein CTD PMID:16720731 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO tibolone metabolite results in increased activity of ESR2 protein; tibolone results in increased activity of ESR2 protein CTD PMID:16720731 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO tibolone metabolite results in increased expression of F3 protein; tibolone results in increased expression of F3 protein CTD PMID:16011840 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression ISO tibolone results in increased expression of FKBP5 mRNA CTD PMID:22217510 NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO tibolone results in decreased expression of ICAM1 protein CTD PMID:17882670 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 increases expression ISO tibolone results in increased expression of IL13RA1 mRNA CTD PMID:22217510 NCBI chr  X:120,213,670...120,294,777
Ensembl chr  X:120,214,075...120,274,461 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO tibolone metabolite results in decreased phosphorylation of MAPK1 protein; tibolone results in decreased phosphorylation of MAPK1 protein CTD PMID:14764805 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO tibolone metabolite results in decreased phosphorylation of MAPK3 protein; tibolone results in decreased phosphorylation of MAPK3 protein CTD PMID:14764805 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Pgr progesterone receptor increases activity ISO tibolone metabolite results in increased activity of PGR protein; tibolone results in increased activity of PGR protein CTD PMID:16011840 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K decreases expression ISO tibolone results in decreased expression of PPM1K mRNA CTD PMID:22217510 NCBI chr 4:88,942,226...88,969,139
Ensembl chr 4:88,942,386...88,969,136 		JBrowse link
G Sele selectin E decreases expression ISO tibolone results in decreased expression of SELE protein CTD PMID:17882670 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO tibolone metabolite results in increased expression of SERPINE1 protein; tibolone results in increased expression of SERPINE1 protein CTD PMID:16011840 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Smap2 small ArfGAP2 increases expression ISO tibolone results in increased expression of SMAP2 mRNA CTD PMID:22217510 NCBI chr 5:139,815,737...139,862,156
Ensembl chr 5:139,815,739...139,862,126 		JBrowse link
G Tcf7 transcription factor 7 decreases expression ISO tibolone results in decreased expression of TCF7 mRNA CTD PMID:22217510 NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,924,363...36,954,279 		JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO tibolone results in increased expression of TLR2 mRNA CTD PMID:22217510 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tpst1 tyrosylprotein sulfotransferase 1 increases expression ISO tibolone results in increased expression of TPST1 mRNA CTD PMID:22217510 NCBI chr12:32,180,688...32,247,478
Ensembl chr12:32,180,936...32,241,821 		JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 decreases expression ISO tibolone results in decreased expression of UXS1 mRNA CTD PMID:22217510 NCBI chr 9:740,929...818,310
Ensembl chr 9:740,724...818,319 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO tibolone results in decreased expression of VCAM1 protein CTD PMID:17882670 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        pharmaceutical 20359
          drug 20359
            bone density conservation agent 5906
              tibolone 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic polycyclic compound 17588
                                  steroid 15237
                                    hydroxy steroid 14970
                                      17-hydroxy steroid 14815
                                        17beta-hydroxy steroid 13310
                                          tibolone 20
paths to the root