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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sodium hydrogencarbonate
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Accession:CHEBI:32139 term browser browse the term
Definition:An one-carbon compound that has formula CHNaO3.
Synonyms:related_synonym: E 500;   E500;   Formula=CHNaO3;   Formula=CHO3.Na;   InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1;   InChIKey=UIIMBOGNXHQVGW-UHFFFAOYSA-M;   NaHCO3;   Natriumhydrogenkarbonat;   SMILES=[Na+].OC([O-])=O;   Sodium bicarbonate;   baking soda;   bicarbonate of soda;   carbonic acid monosodium salt;   sodium acid carbonate;   sodium hydrogen carbonate
 xref: CAS:144-55-8;   DrugBank:DB01390;   KEGG:C12603;   KEGG:D01203
 xref_mesh: MESH:D017693
 xref: PPDB:2873;   Wikipedia:Sodium_Bicarbonate


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sodium hydrogencarbonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Sodium Bicarbonate results in increased expression of ABCC2 mRNA CTD PMID:29126803 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression EXP Sodium Bicarbonate results in decreased expression of ABCG2 mRNA CTD PMID:29126803 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Car2 carbonic anhydrase 2 decreases expression EXP Sodium Bicarbonate results in decreased expression of CAR2 mRNA CTD PMID:31569818 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Cat catalase multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in decreased activity of CAT protein CTD PMID:25559736 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] CTD PMID:10430982 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Sodium Bicarbonate affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of NFKB2 mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of NFKB2 mRNA] CTD PMID:25559736 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of RELA protein; [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of RELA mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of RELA mRNA] CTD PMID:25559736 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases expression EXP Sodium Bicarbonate results in decreased expression of SLC15A1 mRNA CTD PMID:29126803 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc22a19 solute carrier family 22, member 19 increases expression EXP Sodium Bicarbonate results in increased expression of SLC22A24 mRNA CTD PMID:29126803 NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression EXP Sodium Bicarbonate results in decreased expression of SLC22A6 mRNA CTD PMID:29126803 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc39a8 solute carrier family 39 member 8 multiple interactions EXP SLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of Cadmium Chloride]; SLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of manganese chloride] CTD PMID:21509381 NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) decreases expression EXP Sodium Bicarbonate results in decreased expression of SLC4A1 mRNA CTD PMID:31569818 NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117 		JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases transport
decreases expression		 ISO
EXP		 SLC4A4 protein results in increased transport of Sodium Bicarbonate
Sodium Bicarbonate results in decreased expression of SLC4A4 mRNA		 CTD PMID:18614622 PMID:31569818 NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA] CTD PMID:10430982 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TNF mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TNF mRNA] CTD PMID:25559736 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein; [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA] CTD PMID:25559736 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vim vimentin multiple interactions EXP Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of VIM protein] CTD PMID:10430982 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        pharmacological role 19080
          antacid 180
            sodium hydrogencarbonate 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoanion 54
                                    hydrogencarbonate 32
                                      sodium hydrogencarbonate 18
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