The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A member of the class of benzoic acids that is 4-phenoxybenzoic acid in which the hydrogens ortho to the phenoxy group are substituted by butylamino and sulfamoyl groups. Bumetanide is a diuretic, and is used for treatment of oedema associated with congestive heart failure, hepatic and renal disease.
Bumetanide inhibits the reaction [SLC12A2 gene mutant form promotes the reaction [Glucose results in increased secretion of INS1 protein]] Bumetanide inhibits the reaction [Glucose results in increased secretion of INS1 protein]
[Bumetanide co-treated with trandolapril] results in increased expression of REN protein; Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein]; Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein] Bumetanide results in increased expression of REN protein Bumetanide results in increased expression of REN mRNA
SLC12A2 results in increased susceptibility to Bumetanide Bumetanide results in decreased activity of SLC12A2 protein; Bumetanide results in decreased activity of SLC12A2 protein mutant form Bumetanide inhibits the reaction [SLC12A2 gene mutant form promotes the reaction [Glucose results in increased secretion of INS1 protein]] [calyculin A results in increased phosphorylation of SLC12A2 protein] inhibits the reaction [Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]]; Bumetanide inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
Bumetanide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] SLC22A7 protein results in increased transport of Bumetanide
Bumetanide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] Bumetanide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]
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