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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:saccharin
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Accession:CHEBI:32111 term browser browse the term
Definition:A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.
Synonyms:related_synonym: 1,1-Dioxo-1,2-benzisothiazol-3(2H)-one;   1,1-Dioxo-1,2-dihydro-benzo[d]isothiazol-3-one;   1,2-Benzisothiazol-3(2H)-one 1,1-dioxide;   1,2-Benzisothiazolin-3-one 1,1-dioxide;   1,2-Dihydro-2-ketobenzisosulfonazole;   1,2-Dihydro-2-ketobenzisosulphonazole;   2,3-Dihydro-3-oxobenzisosulfonazole;   2,3-Dihydro-3-oxobenzisosulphonazole;   3-Hydroxybenzisothiazole-S,S-dioxide;   Anhydro-o-sulfaminebenzoic acid;   Benzo-2-sulphimide;   Benzoic acid sulfimide;   Benzoic sulfimide;   Benzoic sulphimide;   Benzosulfimide;   Benzosulphimide;   Benzoylsulfonic Imide;   Saccharimide;   Saccharine;   o-Benzoic sulfimide;   o-Benzosulfimide;   o-Sulfobenzimide;   o-Sulfobenzoic acid imide
 alt_id: CHEBI:49717
 xref: CAS:81-07-2;   Gmelin:4203;   HMDB:HMDB0029723
 xref_mesh: MESH:D012439
 xref: Reaxys:6888;   kegg.drug:D01085;   metacyc.compound:CPD-5581;   pdb-ccd:LSA;   pubmed:24456165;   pubmed:24549104;   pubmed:24739358;   pubmed:24780866;   wikipedia.en:Saccharin
 chemrof_formula: C7H5NO3S
 chemrof_inchikey: CVHZOJJKTDOEJC-UHFFFAOYSA-N
 chemrof_inchi: InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
 chemrof_smiles: O=C1NS(=O)(=O)c2ccccc21


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saccharin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein increases expression ISO Saccharin results in increased expression of AFP mRNA CTD PMID:26272751 NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		EXP Saccharin promotes the reaction [Letrozole results in increased expression of BAX protein]
Saccharin results in increased expression of BAX protein 		CTD PMID:39032681 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		EXP Saccharin results in decreased expression of BCL2 protein
[Letrozole co-treated with Saccharin] results in decreased expression of BCL2 protein 		CTD PMID:39032681 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Ca13 carbonic anhydrase 13 increases expression ISO Saccharin results in increased expression of CAR13 mRNA CTD PMID:19000923 NCBI chr 2:88,649,643...88,680,763
Ensembl chr 2:88,649,625...88,680,763 		JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO Saccharin binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Saccharin promotes the reaction [Letrozole results in increased cleavage of CASP3 protein] CTD PMID:39032681 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Saccharin results in increased expression of CDK1 mRNA CTD PMID:26272751 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist increases expression ISO Saccharin results in increased expression of CER1 mRNA CTD PMID:26272751 NCBI chr 5:102,352,364...102,355,720
Ensembl chr 5:102,352,368...102,355,720 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Saccharin results in increased expression of CHEK1 mRNA CTD PMID:19000923 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression 		EXP Saccharin promotes the reaction [Letrozole results in increased expression of CYP1A1 protein]
Saccharin results in increased expression of CYP1A1 protein 		CTD PMID:39032681 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Saccharin results in increased expression of FOSL1 mRNA CTD PMID:19000923 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391 		JBrowse link
G Gnat3 G protein subunit alpha transducin 3 affects response to substance ISO GNAT3 protein affects the susceptibility to Saccharin CTD PMID:16740645 NCBI chr 4:18,054,551...18,104,332
Ensembl chr 4:18,054,541...18,104,332 		JBrowse link
G Hdac7 histone deacetylase 7 decreases expression ISO Saccharin results in decreased expression of HDAC7 mRNA CTD PMID:26272751 NCBI chr 7:130,803,013...130,841,181
Ensembl chr 7:130,803,013...130,841,017 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Saccharin results in increased expression of HELLS mRNA CTD PMID:19000923 NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:246,114,096...246,159,228 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions
increases expression 		EXP Saccharin promotes the reaction [Letrozole results in increased expression of HSD17B1 protein]
Saccharin results in increased expression of HSD17B1 protein 		CTD PMID:39032681 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Saccharin results in increased expression of IL1RL1 mRNA CTD PMID:19000923 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Saccharin results in increased expression of JUN mRNA CTD PMID:19000923 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Saccharin results in increased expression of JUNB mRNA CTD PMID:19000923 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218 		JBrowse link
G Kdr kinase insert domain receptor increases expression ISO Saccharin results in increased expression of KDR mRNA CTD PMID:26272751 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
increases expression 		EXP Saccharin promotes the reaction [Letrozole results in increased expression of LHB protein]
Saccharin results in increased expression of LHB protein 		CTD PMID:39032681 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions 		EXP Saccharin results in increased phosphorylation of MAPK1 protein
Saccharin promotes the reaction [Letrozole results in increased phosphorylation of MAPK1 protein] 		CTD PMID:39032681 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		EXP Saccharin promotes the reaction [Letrozole results in increased phosphorylation of MAPK3 protein]
Saccharin results in increased phosphorylation of MAPK3 protein 		CTD PMID:39032681 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Saccharin results in increased expression of MCM3 mRNA CTD PMID:19000923 NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:30,715,602...30,733,746 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 decreases expression ISO Saccharin results in decreased expression of MESP1 mRNA CTD PMID:26272751 NCBI chr 1:143,147,671...143,149,189
Ensembl chr 1:143,147,671...143,149,189 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Saccharin results in increased expression of MYC mRNA CTD PMID:26272751 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Myo1e myosin IE increases expression ISO Saccharin results in increased expression of MYO1E mRNA CTD PMID:26272751 NCBI chr 8:79,768,828...79,961,048
Ensembl chr 8:79,753,596...79,961,045 		JBrowse link
G Nes nestin increases expression ISO Saccharin results in increased expression of NES mRNA CTD PMID:26272751 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Saccharin results in increased expression of NOS2 mRNA CTD PMID:28472674 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nup54 nucleoporin 54 increases expression ISO Saccharin results in increased expression of NUP54 mRNA CTD PMID:19000923 NCBI chr14:15,901,936...15,920,335
Ensembl chr14:15,901,991...15,920,334 		JBrowse link
G Orm1 orosomucoid 1 increases expression ISO Saccharin results in increased expression of ORM1 mRNA CTD PMID:19000923 NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:81,788,395...81,791,667 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO Saccharin results in increased expression of PHEX mRNA CTD PMID:19000923 NCBI chr  X:41,422,561...41,671,226
Ensembl chr  X:41,426,101...41,671,226 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO Saccharin results in increased expression of PIK3R5 mRNA CTD PMID:19000923 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539 		JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions
increases expression 		EXP [Letrozole co-treated with Saccharin] results in increased expression of PLCB2 protein
Saccharin results in increased expression of PLCB2 protein 		CTD PMID:39032681 NCBI chr 3:126,134,925...126,158,303
Ensembl chr 3:126,138,736...126,158,221 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression ISO Saccharin results in decreased expression of PNPLA6 mRNA CTD PMID:26272751 NCBI chr12:6,372,284...6,401,632
Ensembl chr12:6,372,293...6,401,631 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Saccharin co-treated with Glucose] binds to PPARA protein; Saccharin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Rad21 RAD21 cohesin complex component increases expression ISO Saccharin results in increased expression of RAD21 mRNA CTD PMID:19000923 NCBI chr 7:85,177,715...85,204,657
Ensembl chr 7:85,177,716...85,204,657 		JBrowse link
G Rif1 replication timing regulatory factor 1 increases expression ISO Saccharin results in increased expression of RIF1 mRNA CTD PMID:19000923 NCBI chr 3:56,963,840...57,017,106
Ensembl chr 3:56,963,854...57,017,106 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO Saccharin results in increased expression of SCARB1 mRNA CTD PMID:19000923 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980 		JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression ISO Saccharin results in decreased expression of SHH mRNA CTD PMID:26272751 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Saccharin results in increased expression of SLC2A1 mRNA CTD PMID:19000923 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression
multiple interactions 		EXP Saccharin results in increased expression of STAR protein
Saccharin promotes the reaction [Letrozole results in increased expression of STAR protein] 		CTD PMID:39032681 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
G Stmn1 stathmin 1 increases expression ISO Saccharin results in increased expression of STMN1 mRNA CTD PMID:19000923 NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842 		JBrowse link
G Tas1r2 taste 1 receptor member 2 multiple interactions
increases expression 		EXP [Letrozole co-treated with Saccharin] results in increased expression of TAS1R2 mRNA
Saccharin results in increased expression of TAS1R2 mRNA 		CTD PMID:39032681 NCBI chr 5:157,192,799...157,208,937
Ensembl chr 5:157,192,799...157,208,937 		JBrowse link
G Tas1r3 taste 1 receptor member 3 affects response to substance
multiple interactions
increases expression 		ISO
EXP 		TAS1R3 protein affects the susceptibility to Saccharin
TRPV1 protein affects the reaction [TAS1R3 protein affects the susceptibility to Saccharin]
Saccharin results in increased expression of TAS1R3 mRNA
[Letrozole co-treated with Saccharin] results in increased expression of TAS1R3 mRNA 		CTD PMID:18804451 PMID:39032681 NCBI chr 5:171,750,937...171,754,993
Ensembl chr 5:171,750,937...171,754,993 		JBrowse link
G Tas2r136 taste receptor, type 2, member 136 increases activity ISO Saccharin results in increased activity of TAS2R31 protein CTD PMID:21629661 NCBI chr 4:167,830,248...167,831,240
Ensembl chr 4:167,830,248...167,831,240 		JBrowse link
G Tfrc transferrin receptor increases expression ISO Saccharin results in increased expression of TFRC mRNA CTD PMID:19000923 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Saccharin results in increased expression of TNF mRNA CTD PMID:28472674 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases activity 		ISO TRPV1 protein affects the reaction [TAS1R3 protein affects the susceptibility to Saccharin]
Saccharin results in increased activity of TRPV1 protein 		CTD PMID:17567713 PMID:18804451 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Saccharin results in increased expression of VEGFA mRNA CTD PMID:19000923 PMID:26272751 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Wnt3 Wnt family member 3 increases expression ISO Saccharin results in increased expression of WNT3 mRNA CTD PMID:26272751 NCBI chr10:89,180,224...89,224,195
Ensembl chr10:89,216,801...89,224,195 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        xenobiotic 19528
          saccharin 50
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteropolycyclic compound 18616
                                    organic heterobicyclic compound 17442
                                      benzothiazoles 158
                                        1,2-benzisothiazole 62
                                          saccharin 50
paths to the root