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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Proscillaridin
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Accession:CHEBI:32065 term browser browse the term
Synonyms:related_synonym: Formula=C30H42O8;   InChI=1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19-,20+,21-,22+,24-,25+,26+,27-,28-,29+,30-/m0/s1;   InChIKey=MYEJFUXQJGHEQK-ALRJYLEOSA-N;   SMILES=C[C@@H]1O[C@@H](O[C@H]2CC[C@]3(C)[C@H]4CC[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CCC3=C2)C6=COC(=O)C=C6)[C@H](O)[C@H](O)[C@H]1O;   caradrin;   cardiovite;   desglucotransvaaline;   procardin;   proscillaridin A;   scillacrist
 xref: CAS:466-06-8;   Drug_Central:2313;   KEGG:D01379
 xref_mesh: MESH:D011442


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Proscillaridin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport		 ISO Proscillaridin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
ABCB1 protein results in increased transport of Proscillaridin		 CTD PMID:23104431 PMID:26708294 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Proscillaridin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Proscillaridin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Proscillaridin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Proscillaridin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO Proscillaridin inhibits the reaction [TARDBP protein binds to TARDBP protein] CTD PMID:23891805 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Proscillaridin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19819
          carbon atom 19772
            organic molecular entity 19772
              Proscillaridin 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            Proscillaridin 7
paths to the root