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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxatomide
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Accession:CHEBI:31943 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug.
Synonyms:exact_synonym: 1-{3-[4-(diphenylmethyl)piperazin-1-yl]propyl}-1,3-dihydro-2H-benzimidazol-2-one
 related_synonym: 1-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one;   Cenacert;   Cobiona;   Formula=C27H30N4O;   InChI=1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32);   InChIKey=BAINIUMDFURPJM-UHFFFAOYSA-N;   KW-4354;   R 35 443;   R 35443;   SMILES=O=C1NC2=C(C=CC=C2)N1CCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1;   Tinset;   celtect;   celtomide;   oxatomida;   oxatomidum
 xref: CAS:60607-34-3;   Chemspider:4454;   DrugBank:DB12877;   Drug_Central:2014;   HMDB:HMDB0240225;   KEGG:D01773
 xref_mesh: MESH:C015408
 xref: PMID:10513346;   PMID:12095890;   PMID:12635496;   PMID:12804426;   PMID:14685044;   PMID:18348338;   PMID:22464080;   PMID:24134630;   PMID:24474428;   PMID:26463039;   PMID:33896411;   PMID:3447306;   PMID:6130032;   PMID:6130033;   PMID:6131021;   PMID:6138301;   PMID:6475104;   PMID:6986007;   PMID:7465684;   Patent:WO9858924;   Reaxys:4724760;   Wikipedia:Oxatomide


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oxatomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO oxatomide results in decreased activity of CYP2D6 protein CTD PMID:15684493 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
decreases activity		 ISO CYP3A4 protein results in increased metabolism of oxatomide
oxatomide results in decreased activity of CYP3A4 protein		 CTD PMID:15684493 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Hexb hexosaminidase subunit beta affects secretion EXP oxatomide affects the secretion of HEXB protein CTD PMID:7655991 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO oxatomide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        anti-inflammatory agent 16700
          oxatomide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        tertiary amino compound 10155
                                          N-alkylpiperazine 3404
                                            oxatomide 4
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