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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nimetazepam
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Accession:CHEBI:31912 term browser browse the term
Definition:A nitrazepam which is substituted at positions 1 by a methyl group. It is used as an anticonvulsant and as a hypnotic for the short-term management of insomnia.
Synonyms:related_synonym: 1-methyl-7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one;   1-methylnitrazepam;   Dormalon;   Erimin;   Formula=C16H13N3O3;   InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3;   InChIKey=GWUSZQUVEVMBPI-UHFFFAOYSA-N;   Ro 5-3453;   SMILES=CN1c2ccc(cc2C(=NCC1=O)c1ccccc1)[N+]([O-])=O;   methylnitrazepam;   nimetazepamum
 xref: CAS:2011-67-8;   Drug_Central:1936;   KEGG:D01593;   LINCS:LSM-5785
 xref_mesh: MESH:C002714
 xref: PMID:1154804;   PMID:1274372;   PMID:2241855;   PMID:23085494;   PMID:23245766;   PMID:6151222;   PMID:7452466;   Patent:DE1816046;   Patent:US3109843;   Patent:US3121114;   Patent:US3141890;   Patent:US3144439;   Patent:US3203990;   Patent:US3243427;   Reaxys:759813;   Wikipedia:Nimetazepam


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nimetazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein]; CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein]; CYP3A4 protein results in increased metabolism of and results in increased activity of nimetazepam CTD PMID:19005028 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO nimetazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biophysical role 14048
          membrane transport modulator 13884
            GABA modulator 5114
              nimetazepam 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organonitrogen heterocyclic compound 18153
                                    benzodiazepine 926
                                      1,4-benzodiazepinone 126
                                        nitrazepam 8
                                          nimetazepam 4
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