N-methyl-D-aspartic acid - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	N-methyl-D-aspartic acid	go back to main search page
Accession:	CHEBI:31882	browse the term
Definition:	An aspartic acid derivative having an N-methyl substituent and D-configuration.
Synonyms:	related_synonym:	(R)-2-Methylamino-succinic acid; 2-Methylamino-succinic acid; Formula=C5H9NO4; InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1; InChIKey=HOKKHZGPKSLGJE-GSVOUGTGSA-N; Methyl aspartic acid; N-Methyl aspartic acid; N-Methyl-D-aspartate; N-Methylaspartate; NMDA; SMILES=CN[C@H](CC(O)=O)C(O)=O
	alt_id:	CHEBI:164776
	xref:	CAS:6384-92-5; HMDB:HMDB0002393; KEGG:C12269
	xref_mesh:	MESH:D016202
	xref:	MetaCyc:CPD-10705; PDBeChem:OEM; PMID:10514280; PMID:10893301; PMID:1967316; PMID:2170646; PMID:3351864; PMID:8568805; PMID:9572889; Reaxys:1724431; Wikipedia:N-Methyl-D-aspartic_acid

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Genes (43)

N-methyl-D-aspartic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

N-Methylaspartate results in decreased phosphorylation of AKT1 protein
kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

activating transcription factor 4

multiple interactions

N-Methylaspartate results in decreased expression of [Esketamine results in increased expression of ATF4 protein]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of ATP1A1 protein]

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase Na+/K+ transporting subunit alpha 2

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of ATP1A2 protein]

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase plasma membrane Ca2+ transporting 1

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of ATP2B1 protein]

NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

N-Methylaspartate results in increased expression of BAX protein
kukoamine B inhibits the reaction [N-Methylaspartate results in increased expression of BAX protein]; N-Methylaspartate affects the reaction [Esketamine affects the expression of BAX mRNA]

PMID:26065936 PMID:38219984

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

kukoamine B inhibits the reaction [N-Methylaspartate results in decreased expression of BCL2 protein]; N-Methylaspartate affects the reaction [Esketamine affects the expression of BCL2 mRNA]

PMID:26065936 PMID:38219984

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calcium voltage-gated channel subunit alpha1 A

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNA1A protein]

NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225

G

calcium voltage-gated channel subunit alpha1 B

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNA1B protein]

NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091

G

calcium voltage-gated channel auxiliary subunit beta 1

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNB1 protein]

NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694

G

calcium voltage-gated channel auxiliary subunit beta 4

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNB4 protein]

NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944

G

calpain 2

increases activity

NMDA increases activity of Capn2 in rat hippocampal neuron cultures

RGD

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

caveolin 1

increases phosphorylation
multiple interactions

N-Methylaspartate results in increased phosphorylation of CAV1 protein
CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]; CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]; CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK3 protein]

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

cyclin-dependent kinase 5

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CDK5 protein]

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

G

cAMP responsive element binding protein 1

multiple interactions
decreases phosphorylation

kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of CREB1 protein]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

DNA-damage inducible transcript 3

multiple interactions

N-Methylaspartate results in decreased expression of [Esketamine results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

D-aspartate oxidase

affects abundance

DDO protein affects the abundance of N-Methylaspartate

NCBI chr20:44,090,823...44,109,962
Ensembl chr20:44,090,914...44,133,095

G

DLG associated protein 1

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of DLGAP1 protein]

NCBI chr 9:109,857,500...110,726,817
Ensembl chr 9:110,167,448...110,726,817

G

ELAV like RNA binding protein 1

increases phosphorylation
multiple interactions

N-Methylaspartate results in increased phosphorylation of ELAVL1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]

NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784

G

FYN proto-oncogene, Src family tyrosine kinase

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of FYN protein]

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

G

gephyrin

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of GPHN protein]

NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612

G

glutamate ionotropic receptor NMDA type subunit 2B

increases expression
multiple interactions

N-Methylaspartate results in increased expression of GRIN2B protein
kukoamine B inhibits the reaction [N-Methylaspartate results in increased expression of GRIN2B protein]

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glycogen synthase kinase 3 beta

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of HCN2 protein]

NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841

G

lamin A/C

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of LMNA protein]

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

mitogen activated protein kinase 1

increases expression
multiple interactions
decreases phosphorylation
increases phosphorylation

N-Methylaspartate results in increased expression of MAPK1 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK1 protein modified form]
CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]; kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]

PMID:22639866 PMID:26065936 PMID:35257817

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases expression
multiple interactions
decreases phosphorylation
increases phosphorylation

N-Methylaspartate results in increased expression of MAPK3 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK3 protein modified form]
N-Methylaspartate results in decreased phosphorylation of MAPK3 protein
CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK3 protein]; kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of MAPK3 protein]

PMID:22639866 PMID:26065936 PMID:35257817

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of MAPT protein]

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

neutrophil cytosolic factor 1

multiple interactions
affects localization

acetovanillone inhibits the reaction [N-Methylaspartate affects the localization of NCF1 protein]

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

neurofilament light chain

multiple interactions
decreases expression

3-(2-((phenylamino)carbonyl)ethenyl)-4,6-dichloroindole-2-carboxylic acid inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Memantine inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

nitric oxide synthase 1

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of NOS1 protein]

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

poly (ADP-ribose) polymerase 1

increases ADP-ribosylation

N-Methylaspartate results in increased ADP-ribosylation of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

protein kinase C, gamma

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of PRKCG protein]

NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384

G

RAB3A, member RAS oncogene family

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of RAB3A protein]

NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336

G

regulating synaptic membrane exocytosis 1

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of RIMS1 protein]

NCBI chr 9:24,696,959...25,196,404
Ensembl chr 9:24,698,854...25,196,631

G

SH3 and multiple ankyrin repeat domains 2

decreases expression

N-Methylaspartate results in decreased expression of SHANK2 mRNA

NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394

G

SH3 and multiple ankyrin repeat domains 3

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of SHANK3 protein]

NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374

G

sirtuin 1

multiple interactions
decreases expression

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

syntaxin binding protein 1

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of STXBP1 protein]

NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369

G

synapsin I

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of SYN1 protein]

NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396

G

tight junction protein 1

decreases expression
multiple interactions

N-Methylaspartate results in decreased expression of TJP1 mRNA; N-Methylaspartate results in decreased expression of TJP1 protein
CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; U 0126 inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

tubulin, alpha 1B

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of TUBA1B protein]

NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186

G

voltage-dependent anion channel 2

multiple interactions

N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of VDAC2 protein]

NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19898
role	19868
biological role	19866
pharmacological role	19098
neurotransmitter agent	16808
N-methyl-D-aspartic acid	43
Path 2
Term	Annotations
CHEBI ontology	19898
subatomic particle	19896
composite particle	19896
hadron	19896
baryon	19896
nucleon	19896
atomic nucleus	19896
atom	19896
main group element atom	19835
main group molecular entity	19835
s-block molecular entity	19670
hydrogen molecular entity	19651
hydrides	19158
inorganic hydride	18176
pnictogen hydride	18166
nitrogen hydride	18079
azane	17886
ammonia	17885
organic amino compound	17885
amino acid	16072
non-proteinogenic amino acid	3998
non-proteinogenic alpha-amino acid	3804
D-alpha-amino acid	68
D-aspartic acid	62
D-aspartic acid derivative	43
N-methyl-D-aspartic acid	43

paths to the root