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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:brompheniramine
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Accession:CHEBI:3183 term browser browse the term
Definition:Pheniramine in which the hydrogen at position 4 of the phenyl substituent is substituted by bromine. A histamine H1 receptor antagonist, brompheniramine is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.
Synonyms:related_synonym: 1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane;   2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine;   3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine;   3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine;   3-(p-bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine;   [3-(4-Bromo-phenyl)-3-pyridin-2-yl-propyl]-dimethyl-amine;   bromfeniramina;   brompheniraminum
 alt_id: CHEBI:154051
 xref: Beilstein:217066;   CAS:86-22-6;   DrugBank:DB00835
 xref_mesh: MESH:D001977
 xref: Patent:US2567245;   Patent:US2676964;   drugcentral:408;   kegg.compound:C06857;   kegg.drug:D07543;   lincs.smallmolecule:LSM-1736;   pubmed:2570152;   pubmed:2579237;   pubmed:6458703;   pubmed:9526560;   wikipedia.en:Brompheniramine
 chemrof_formula: C16H19BrN2
 chemrof_smiles: CN(C)CCC(c1ccc(Br)cc1)c1ccccn1
 chemrof_inchi: InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
 chemrof_inchikey: ZDIGNSYAACHWNL-UHFFFAOYSA-N


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brompheniramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Brompheniramine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Brompheniramine results in decreased activity of KCNH2 protein CTD PMID:17010640 PMID:17516459 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Brompheniramine results in decreased activity of SCN5A protein CTD PMID:17010640 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Brompheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
dexbrompheniramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO dexbrompheniramine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO dexbrompheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        pharmaceutical 20359
          drug 20359
            anti-allergic agent 3963
              brompheniramine 4
                brompheniramine maleate + 0
                dexbrompheniramine + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteromonocyclic compound 18004
                                    pyridines 12197
                                      brompheniramine 4
                                        brompheniramine maleate + 0
                                        dexbrompheniramine + 2
paths to the root