Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fleroxacin
go back to main search page
Accession:CHEBI:31810 term browser browse the term
Definition:A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-negative bacteria.
Synonyms:exact_synonym: 6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid-;   Formula=C17H18F3N3O3;   InChI=1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26);   InChIKey=XBJBPGROQZJDOJ-UHFFFAOYSA-N;   SMILES=C12=C(N(C=C(C(O)=O)C1=O)CCF)C(=C(N3CCN(CC3)C)C(F)=C2)F;   fleroxacine;   fleroxacino;   fleroxacinum
 xref: Beilstein:4300996;   CAS:79660-72-3;   DrugBank:DB04576;   Drug_Central:1177;   KEGG:C13179;   KEGG:D01716;   LINCS:LSM-6633
 xref_mesh: MESH:D016576
 xref: PMID:25143490;   PMID:26963935;   PMID:27301999;   PMID:3095363;   Patent:US4398029;   Reaxys:4300996;   Wikipedia:Fleroxacin



show annotations for term's descendants           Sort by:
fleroxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Fleroxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19915
    role 19885
      biological role 19883
        antimicrobial agent 18267
          fluoroquinolone antibiotic 2078
            fleroxacin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19915
    subatomic particle 19913
      composite particle 19895
        hadron 19895
          baryon 19913
            nucleon 19895
              atomic nucleus 19913
                atom 19895
                  main group element atom 19852
                    main group molecular entity 19834
                      s-block molecular entity 19685
                        hydrogen molecular entity 19647
                          hydrides 19151
                            inorganic hydride 18162
                              pnictogen hydride 18152
                                nitrogen hydride 18065
                                  azane 17894
                                    ammonia 17893
                                      organic amino compound 17893
                                        tertiary amino compound 10150
                                          N-alkylpiperazine 3404
                                            fleroxacin 1
paths to the root