CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Medazepam
Accession: CHEBI:31807
browse the term
Synonyms: related_synonym: Formula=C16H15ClN2; InChI=1S/C16H15ClN2/c1-19-10-9-18-16(12-5-3-2-4-6-12)14-11-13(17)7-8-15(14)19/h2-8,11H,9-10H2,1H3; InChIKey=YLCXGBZIZBEVPZ-UHFFFAOYSA-N; SMILES=C1(=CC2=C(C=C1)N(CCN=C2C=3C=CC=CC3)C)Cl; medazepam HCl; medazepam hydrochloride; mezapam
xref: CAS:2898-12-6; Drug_Central:1654; KEGG:D01292
xref_mesh: MESH:D008472
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Akr1c1
aldo-keto reductase family 1, member C1
decreases activity
ISO
Medazepam results in decreased activity of AKR1C1 protein
CTD
PMID:11995921 PMID:12604236
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c2
aldo-keto reductase family 1, member C2
decreases activity
ISO
Medazepam results in decreased activity of AKR1C2 protein
CTD
PMID:11995921 PMID:12604236
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1c3
aldo-keto reductase family 1, member C3
decreases activity
ISO
Medazepam results in decreased activity of AKR1C3 protein
CTD
PMID:11995921 PMID:12604236
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
ISO
Medazepam results in increased expression of CYP3A4 mRNA
CTD
PMID:20080160
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions increases activity
ISO
Medazepam binds to and results in increased activity of NR1I2 protein Medazepam results in increased activity of NR1I2 protein
CTD
PMID:20024649 PMID:20080160
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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