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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lentinan
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Accession:CHEBI:31770 term browser browse the term
Definition:A 1,3 beta-glucan polysaccharide with beta-1,6 branching isolated from the edible mushroom Lentinula edodes. It has a molecular weight of around 500,000 Da; the exact composition is unknown.
Synonyms:related_synonym: Formula=(C42H70O35)n;   WURCS=2.0/1,7,6/[a2122h-1b_1-5]/1-1-1-1-1-1-1/a3-b1_a6-g1_b3-c1_c3-d1_d3-e1_d6-f1
 xref: CAS:37339-90-5;   DrugBank:DB13480;   GlyGen:G09583ED;   GlyTouCan:G09583ED;   KEGG:C13156;   KEGG:D01695
 xref_mesh: MESH:D007912
 xref: Wikipedia:Lentinan


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lentinan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO Lentinan results in decreased expression of CYP1A1 CTD PMID:15630237 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression ISO Lentinan results in decreased expression of CYP1A2 CTD PMID:15630237 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Lentinan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22102286 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Lentinan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22102286 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Lentinan inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Lentinan inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22102286 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions		 ISO Lentinan results in increased activity of RELA
Lentinan promotes the reaction [Lipopolysaccharides results in increased localization of RELA protein]		 CTD PMID:15630237 PMID:22102286 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO Lentinan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Lentinan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Lentinan results in increased expression of TNF		 CTD PMID:15630237 PMID:22102286 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        immunomodulator 15081
          lentinan 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbohydrates and carbohydrate derivatives 15275
                                    carbohydrate 15302
                                      polysaccharide 8219
                                        homopolysaccharide 5820
                                          glucan 5004
                                            lentinan 7
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