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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ipriflavone
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Accession:CHEBI:31719 term browser browse the term
Definition:A member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women.
Synonyms:exact_synonym: 7-isopropoxy-3-phenyl-4H-chromen-4-one
 related_synonym: 7-(1-methylethoxy)-3-phenyl-4H-1-benzopyran-4-one;   7-isopropoxyisoflavone;   FL-113;   Formula=C18H16O3;   InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3;   InChIKey=SFBODOKJTYAUCM-UHFFFAOYSA-N;   Iprosten;   Osten;   SMILES=CC(C)Oc1ccc2c(c1)occ(-c1ccccc1)c2=O;   Yambolap;   ipriflavona;   ipriflavonum
 xref: CAS:35212-22-7;   Drug_Central:1477;   HMDB:HMDB0032987;   KEGG:D01338;   LINCS:LSM-5981
 xref_mesh: MESH:C018986
 xref: PMID:11255425;   PMID:17297162;   PMID:21594876;   PMID:23265084;   PMID:24084576;   PMID:24389340;   PMID:24404906;   PMID:7196240;   PMID:8148667;   PMID:8461568;   PMID:9263607;   PMID:9263610;   PMID:9263615;   PMID:9517377;   PMID:9988779;   Patent:DE2125245;   Patent:US3833730;   Patent:US3949085;   Reaxys:4754346;   Wikipedia:Ipriflavone



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ipriflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO ipriflavone binds to and results in increased activity of ESR1 protein CTD PMID:9751507 NCBI chr 1:43,511,685...43,904,454 JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO ipriflavone binds to and results in increased activity of ESR2 protein CTD PMID:9751507 NCBI chr 6:100,589,553...100,645,240 JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO ipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 7:65,042,237...65,054,888 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO ipriflavone results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424 JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO ipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 4:6,954,017...6,963,170 JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      application 19715
        pharmaceutical 19551
          drug 19551
            bone density conservation agent 6072
              ipriflavone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                organic heterocyclic compound 18896
                                  oxacycle 17924
                                    benzopyran 11981
                                      1-benzopyran 11735
                                        isoflavonoid 3831
                                          isoflavones 3812
                                            ipriflavone 5
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